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Increasing the Distance between the Dermoscope and the Surgical Site during Intraoperative Dermoscopy 增加术中皮肤镜与手术部位的距离
IF 1 Q2 Medicine Pub Date : 2024-03-28 DOI: 10.1159/000538166
Ozan Erdem, Fatih Göktay
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引用次数: 0
Median Canaliform Dystrophy of Heller in a Carpet Weaver: A New Risk Factor? – A Case Report 一名地毯织工的海勒中线管状营养不良症:新的风险因素?- 病例报告
IF 1 Q2 Medicine Pub Date : 2024-03-28 DOI: 10.1159/000538185
F. Z. El Fatoiki, A. El Kissouni, Soumiya Chiheb
Introduction: Median canaliform dystrophy of Heller (MCDH) is a rare nail disorder that typically affects the thumbnails and is characterized by transverse ridges radiating from a paramedian canal or split in the nail plate, bearing resemblance to a fir tree. Case Report: We report here a case of a 60-year-old woman of rural origin, a carpet weaver, with no specific medical history. She was referred due to nail dystrophy on her thumbs that had been progressing over the last 10 years. Clinical examination revealed the presence of a midline splitting with a fir tree-like appearance of ridges angled backwards and normal cuticle. These lesions were symmetrically present on both thumbnails and the big toe nail. Based on this presentation, a diagnosis of Heller's canaliform dystrophy was established. Conclusion: Although the pathophysiology of MCDH remains unclear, proposed mechanisms include keratinocyte adhesion abnormalities, genetic predisposition, and inflammation within the nail matrix. Risk factors encompass medications like oral retinoids and self-inflicted trauma, as seen in repetitive cuticle manipulation. In this case, the patient’s nail dystrophy resulted from chronic local microtrauma due to her carpet weaving occupation, suggesting certain manual professions may contribute to MCDH development.
简介海勒氏正中管状营养不良症(MCDH)是一种罕见的指甲疾病,通常会影响拇指指甲,其特征是从甲板的正中管或裂口处放射出的横脊,酷似一棵杉树。病例报告:我们在此报告一例 60 岁的农村妇女,她是一名地毯编织工,没有特殊病史。她因拇指甲营养不良而被转诊,该病在过去 10 年中一直在发展。临床检查发现,她的拇指中线出现劈裂,甲脊向后倾斜,呈杉树状,角质层正常。这些病变对称出现在两个拇指指甲和大脚趾甲上。根据这种表现,海勒管状营养不良症的诊断得以确立。结论虽然 MCDH 的病理生理学尚不清楚,但提出的机制包括角质细胞粘附异常、遗传易感性和甲基质内的炎症。风险因素包括口服维甲酸等药物和自身造成的创伤,如反复操作角质层。在本病例中,患者的甲营养不良症是由于她从事地毯编织工作造成的慢性局部微创伤引起的,这表明某些手工职业可能会导致甲营养不良症的发生。
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引用次数: 0
Advantages of Nail Surgical Procedures Using a 3D Biomodel 使用 3D 生物模型进行指甲手术的优势
IF 1 Q2 Medicine Pub Date : 2024-03-26 DOI: 10.1159/000537871
R. Nakamura, A. Leverone, Carolina Ávila de Almeida, Heron Werner, Clarissa Canella
Introduction: 3D biomodels represent a cutting-edge advancement in medical imaging technology. The incorporation of 3D technologies in dermatology through the acquisition of onychological images, 3D reconstruction, and development of customized equipment to assist in surgeries demonstrated reduction in operating times and improved surgical outcomes. Additionally, the use of 3D printing in surgical simulation provided a safe environment for training and education. This article explores the application of 3D biomodels in dermatology, focusing on three clinical cases involving nail tumors. Case Presentation: In case 1, a glomus tumor was visualized in 3D, guiding the creation of a personalized surgical device. The minimally invasive surgery, facilitated by the biomodel, resulted in successful tumor removal. Case 2, featuring a subungual keratoacanthoma, utilized 3D biomodels for conservative surgery planning, anatomical comprehension, and patient communication. Case 3 involved a longitudinal groove, where biomodels aided in precise lesion localization and surgical planning. Conclusion: The integration of virtual and physical anatomical biomodels proves valuable in surgical dermatology, contributing to enhanced treatment quality, patient safety, and medical education.
导言:三维生物模型代表着医学成像技术的尖端进步。将三维技术应用于皮肤病学,通过获取虹膜图像、三维重建和开发定制设备来协助手术,缩短了手术时间,提高了手术效果。此外,在手术模拟中使用三维打印技术为培训和教育提供了一个安全的环境。本文探讨了三维生物模型在皮肤科中的应用,重点是三个涉及甲状腺肿瘤的临床病例。病例介绍:在病例 1 中,通过三维可视化观察了一个甲状腺肿瘤,从而指导创建了一个个性化的手术装置。在生物模型的帮助下,微创手术成功切除了肿瘤。病例 2 涉及舌下角化棘皮瘤,利用三维生物模型进行保守手术规划、解剖理解和患者沟通。病例 3 涉及纵沟,生物模型帮助进行了精确的病灶定位和手术规划。结论虚拟和物理解剖生物模型的整合在皮肤外科手术中很有价值,有助于提高治疗质量、患者安全和医学教育。
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引用次数: 0
Classification of Retronychia: A Narrative Clinical Review 视网膜胬肉的分类:叙述性临床回顾
IF 1 Q2 Medicine Pub Date : 2024-03-25 DOI: 10.1159/000537907
André Lencastre, Bertrand Richert
Background: A retronychia classification system is overdue considering the most recent publications. Using the keyword “retronychia”, publications with a narrative literature review were selected from PubMed/MEDLINE, EMBASE and Google Scholar, adding a few select papers. Summary: This article proposes a theoretical pathophysiological basis for retronychia. Several factors alter the clinical picture of retronychia: length and periodicity of backward displacement, duration of disease, intensity of paronychia, presence and type of nail stacking (polymeronychia), and remodeling of the nail apparatus (elevation of the proximal nail, nail bed shortening, retroversion of the distal nail fold and acquired malalignment). Key Messages: With these factors in mind, we propose a new classification system for retronychia: A standing for acute, O for ongoing, and C for chronic. We believe this easy system may increase the diagnostic acuity for the disease and its understanding.
背景:考虑到最新发表的文献,再虹膜睫状体分类系统早该建立。本文以 "retronychia "为关键词,从 PubMed/MEDLINE、EMBASE 和 Google Scholar 中选取了具有叙述性文献综述的出版物,并添加了一些精选论文。摘要:本文提出了再瘤形成的病理生理学理论基础。有几个因素会改变再障的临床表现:向后移位的长度和周期性、病程、甲旁癣的强度、甲堆积(聚合癣)的存在和类型、甲器的重塑(近端甲抬高、甲床缩短、远端甲皱襞后移和获得性错位)。关键信息:考虑到这些因素,我们提出了一种新的再趾甲分类系统:A 代表急性,O 代表持续性,C 代表慢性。我们相信,这种简便的系统可提高疾病诊断的敏锐度和对疾病的认识。
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引用次数: 0
Surgical Management of Difficult Nail Glomus Tumors 疑难甲状腺结节肿瘤的手术治疗
IF 1 Q2 Medicine Pub Date : 2024-03-25 DOI: 10.1159/000538028
N. Gioia Di Chiacchio, N. D. Di Chiacchio
Background: Nail glomus tumor is a well-known tumor, with well-defined clinical characteristics and surgical treatment; however, some of these lesions occur in different locations and sizes with difficult surgical resolution. Summary: Clinical and imaging tests help in the diagnosis and tumor localization. Key Message: Adequate surgical knowledge for these cases ensures lower rates of recurrence and nail dystrophy.
背景:甲状腺瘤是一种众所周知的肿瘤,具有明确的临床特征和手术治疗方法;但其中一些病变发生在不同的位置和大小,手术难以解决。摘要:临床和影像学检查有助于诊断和肿瘤定位。关键信息:对这些病例有足够的手术知识可确保降低复发率和甲营养不良率。
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引用次数: 0
A Case of Dissecting Cellulitis of the Scalp, Hidradenitis Suppurativa, and Conglobate Acne Successfully Treated with Secukinumab 一例使用塞库单抗成功治疗头皮剥脱性蜂窝织炎、化脓性湿疹和充血性痤疮的病例
IF 1 Q2 Medicine Pub Date : 2024-03-18 DOI: 10.1159/000537914
N. Schettini, Elisa Marzola, Lucrezia Pacetti, Simone Cavaliere, Vincenzo Bettoli
Introduction: Dissecting cellulitis of the scalp (DCS) is a neutrophilic scarring alopecia typically presenting with pustules and fluctuant nodules, followed by suppuration and sinus tract formation. DCS is often associated with other diseases, such as hidradenitis suppurativa (HS) and conglobate acne (CA) which share similar pathogenetic mechanisms. Case Presentation: The authors report the case of a patient affected by a severe form of DCS, HS, and CA of the face. Previous treatments with isotretinoin, antibiotics, and adalimumab did not have a considerable efficacy. Off-label treatment with secukinumab showed a gradual improvement in the clinical presentation bringing to a reduction in the number of HS lesions and to an almost complete resolution of the inflammatory manifestations of DCS. Conclusion: Management of DCS is challenging and is typically based on retinoids which are considered the first line of treatment. The efficacy of biologic drugs, especially TNFα inhibitors, in severe and relapsing forms of DCS has been reported in recent literature. To our knowledge, only one case of isolated DCS treated with secukinumab is reported. No cases of concomitant DCS and HS, treated with this type of IL-17 inhibitor, have been described.
导言:头皮剥脱性蜂窝织炎(DCS)是一种嗜中性瘢痕性脱发,通常表现为脓疱和波动性结节,随后化脓并形成窦道。头皮裂孔性脱发常与其他疾病相关,如化脓性扁桃体炎(HS)和充血性痤疮(CA),它们的发病机制相似。病例介绍:作者报告了一例面部患有严重 DCS、HS 和 CA 的患者。患者曾接受过异维A酸、抗生素和阿达木单抗治疗,但疗效不佳。使用secukinumab进行标示外治疗后,患者的临床表现逐渐改善,HS皮损数量减少,DCS的炎症表现几乎完全消退。结论DCS的治疗具有挑战性,通常以维甲酸类药物为一线治疗药物。最近有文献报道,生物药物,尤其是 TNFα 抑制剂,对重症和复发性 DCS 有一定疗效。据我们所知,目前仅有一例使用secukinumab治疗的孤立性DCS病例。目前还没有使用这种IL-17抑制剂治疗DCS和HS并发症的病例。
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引用次数: 0
Exposome Impact on Nail Health 暴露基因组对指甲健康的影响
IF 1 Q2 Medicine Pub Date : 2024-03-11 DOI: 10.1159/000536573
Ludmila Prudkin, S. Cedirian, Júlia Santamaria, Eric Jourdan, B. M. Piraccini
Background: The nail unit is a complex system with various components, each serving distinct functions. The exposome, encompassing external and internal factors such as UV radiation, air pollution, dietary habits, and cosmetic product usage, substantially influences nail health and can lead to premature nail aging. Summary: Internal and external exposomal factors can impact differently on nail health, inducing a variety of different clinical conditions. Effective therapeutic strategies exist, but a comprehensive understanding of how the exposome affects nails is lacking. This article aims to bridge this knowledge gap by exploring the relationship between the exposome and nail health, emphasizing it as a central focus of our analysis. Key Messages: (1) The exposome, comprising various external and internal factors, may significantly influence nail health negatively, leading to premature nail aging. (2) Different nail conditions may arise due to the exposomal influence on nails. (3) Understanding the exposome’s impact on nail health is crucial for developing solutions to mitigate negative effects and improve overall nail well-being.
背景:指甲是一个复杂的系统,由多种成分组成,每种成分都具有不同的功能。暴露体包括紫外线辐射、空气污染、饮食习惯和化妆品使用等外部和内部因素,对指甲健康有重大影响,并可能导致指甲过早老化。摘要:内部和外部暴露因素会对指甲健康产生不同的影响,诱发各种不同的临床症状。目前已有有效的治疗策略,但对暴露体如何影响指甲还缺乏全面的了解。本文旨在通过探讨暴露体与指甲健康之间的关系来弥补这一知识空白,并强调暴露体是我们分析的核心重点。主要信息:(1)由各种外部和内部因素组成的暴露组可能对指甲健康产生重大负面影响,导致指甲过早老化。(2)由于暴露体对指甲的影响,可能会导致不同的指甲状况。(3)了解暴露体对指甲健康的影响对于制定减轻负面影响和改善指甲整体健康的解决方案至关重要。
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引用次数: 0
Cytokine-Mediated Molecular Pathophysiology of Hidradenitis Suppurativa: A Narrative Review 细胞因子介导的扁平湿疹分子病理生理学:叙述性综述
IF 1 Q2 Medicine Pub Date : 2024-02-27 DOI: 10.1159/000536268
Julian Melchor, Stuti Prajapati, Rita O. Pichardo, Steven R. Feldman
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory condition of the skin that mainly affects the apocrine gland-rich intertriginous areas. The disease manifests as painful nodules, abscesses, and pus-filled tunnels, which can severely impact patient’s quality of life. While diagnosis is clinical, successful treatment options for this condition are limited. There has been an increase in research and clinical trials focusing on biomarkers and cytokines for clinical use. Understanding the potential biomarkers and cytokines implicated in HS pathogenesis may allow efficacious and safe treatment options. Summary: A literature review was conducted on nine biomarkers and cytokines. IL-1, IL-10, IL-17, IL-23, TNF-α, YKL-40, G-CSF, NOD2, and the complement system were identified due to their potential clinical utilization and pathophysiological involvement in HS. Key Messages: With further research expanding our understanding of the pathophysiology of HS and the roles these cytokines and biomarkers play, there is potential for utilization as diagnostic markers or development of antagonists against these specific agents for HS management.
背景:化脓性扁平湿疹(HS)是一种慢性皮肤炎症,主要影响皮脂腺丰富的三叉神经间区域。该病表现为疼痛的结节、脓肿和充满脓液的隧道,严重影响患者的生活质量。虽然该病的诊断是临床性的,但成功的治疗方案却很有限。越来越多的研究和临床试验关注临床使用的生物标志物和细胞因子。了解与房颤发病机制有关的潜在生物标志物和细胞因子可提供有效、安全的治疗方案。摘要:我们对九种生物标志物和细胞因子进行了文献综述。由于IL-1、IL-10、IL-17、IL-23、TNF-α、YKL-40、G-CSF、NOD2和补体系统在HS中的潜在临床应用和病理生理参与,这些生物标志物和细胞因子被确定下来。关键信息:随着研究的深入,我们对HS的病理生理学以及这些细胞因子和生物标志物的作用有了更深入的了解,因此有可能将其用作诊断标志物,或开发针对这些特定因子的拮抗剂,用于HS的治疗。
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引用次数: 0
Adverse Effects of Do-It-Yourself Nail Cosmetics: A Literature Review 自己动手美甲化妆品的不良影响:文献综述
IF 1 Q2 Medicine Pub Date : 2024-02-09 DOI: 10.1159/000536381
Elise Wang, Shari R. Lipner
Background: As self-applied manicures have gained popularity, it is important for physicians to remain informed about potential associated side effects. Traditional polish remains most popular among nail enthusiasts, but the pursuit of durability and convenience accelerated development of other nail cosmetic products, including gel polish, acrylic nails, and press-on nails. Despite documented adverse effects among beauty professionals and salon customers, individuals practicing at-home nail care routines may face similar, if not more, frequent complications due to misinformation, inadequate training, and social media trends. Summary: This review provides an overview of adverse effects associated with different at-home nail cosmetics. Allergic contact dermatitis is the most prevalent adverse event, primarily attributed to (meth)acrylates found in nail glue, gel polish, and acrylic nails. Other adverse effects include infections, chemical burns, and complications from ultraviolet nail lamps. Key Message: The review highlights the importance of transparent product labeling and appropriate warning labels from manufacturers, as well as physician education and awareness for minimizing risks related to at-home nail cosmetic applications.
背景:随着自行美甲的流行,医生必须了解潜在的相关副作用。传统的指甲油在美甲爱好者中仍然最受欢迎,但对持久性和便利性的追求加速了其他指甲美容产品的发展,包括凝胶指甲油、丙烯酸指甲油和按压式指甲油。尽管美容专业人士和沙龙顾客中存在不良反应的记录,但由于信息错误、培训不足和社交媒体的趋势,从事家庭指甲护理的个人可能会面临类似甚至更频繁的并发症。摘要:本综述概述了与不同家用美甲化妆品相关的不良反应。过敏性接触性皮炎是最常见的不良反应,主要归因于指甲胶、凝胶指甲油和丙烯酸指甲油中的(甲基)丙烯酸酯。其他不良反应包括感染、化学灼伤和紫外线美甲灯引起的并发症。关键信息:综述强调了生产商提供透明产品标签和适当警告标签的重要性,以及医生教育和意识对于最大限度地降低与家庭指甲美容应用相关的风险的重要性。
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引用次数: 0
Adverse Effects of Do-It-Yourself Nail Cosmetics: A Literature Review 自己动手美甲化妆品的不良影响:文献综述
IF 1 Q2 Medicine Pub Date : 2024-02-09 DOI: 10.1159/000536381
Elise Wang, Shari R. Lipner
Background: As self-applied manicures have gained popularity, it is important for physicians to remain informed about potential associated side effects. Traditional polish remains most popular among nail enthusiasts, but the pursuit of durability and convenience accelerated development of other nail cosmetic products, including gel polish, acrylic nails, and press-on nails. Despite documented adverse effects among beauty professionals and salon customers, individuals practicing at-home nail care routines may face similar, if not more, frequent complications due to misinformation, inadequate training, and social media trends. Summary: This review provides an overview of adverse effects associated with different at-home nail cosmetics. Allergic contact dermatitis is the most prevalent adverse event, primarily attributed to (meth)acrylates found in nail glue, gel polish, and acrylic nails. Other adverse effects include infections, chemical burns, and complications from ultraviolet nail lamps. Key Message: The review highlights the importance of transparent product labeling and appropriate warning labels from manufacturers, as well as physician education and awareness for minimizing risks related to at-home nail cosmetic applications.
背景:随着自行美甲的流行,医生必须了解潜在的相关副作用。传统的指甲油在美甲爱好者中仍然最受欢迎,但对持久性和便利性的追求加速了其他指甲美容产品的发展,包括凝胶指甲油、丙烯酸指甲油和按压式指甲油。尽管美容专业人士和沙龙顾客中存在不良反应的记录,但由于信息错误、培训不足和社交媒体的趋势,从事家庭指甲护理的个人可能会面临类似甚至更频繁的并发症。摘要:本综述概述了与不同家用美甲化妆品相关的不良反应。过敏性接触性皮炎是最常见的不良反应,主要归因于指甲胶、凝胶指甲油和丙烯酸指甲油中的(甲基)丙烯酸酯。其他不良反应包括感染、化学灼伤和紫外线美甲灯引起的并发症。关键信息:综述强调了生产商提供透明产品标签和适当警告标签的重要性,以及医生教育和意识对于最大限度地降低与家庭指甲美容应用相关的风险的重要性。
{"title":"Adverse Effects of Do-It-Yourself Nail Cosmetics: A Literature Review","authors":"Elise Wang, Shari R. Lipner","doi":"10.1159/000536381","DOIUrl":"https://doi.org/10.1159/000536381","url":null,"abstract":"Background: As self-applied manicures have gained popularity, it is important for physicians to remain informed about potential associated side effects. Traditional polish remains most popular among nail enthusiasts, but the pursuit of durability and convenience accelerated development of other nail cosmetic products, including gel polish, acrylic nails, and press-on nails. Despite documented adverse effects among beauty professionals and salon customers, individuals practicing at-home nail care routines may face similar, if not more, frequent complications due to misinformation, inadequate training, and social media trends. Summary: This review provides an overview of adverse effects associated with different at-home nail cosmetics. Allergic contact dermatitis is the most prevalent adverse event, primarily attributed to (meth)acrylates found in nail glue, gel polish, and acrylic nails. Other adverse effects include infections, chemical burns, and complications from ultraviolet nail lamps. Key Message: The review highlights the importance of transparent product labeling and appropriate warning labels from manufacturers, as well as physician education and awareness for minimizing risks related to at-home nail cosmetic applications.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139788127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Skin Appendage Disorders
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