Background: Lichen striatus (LS) is a benign, mostly self-limiting dermatological condition, primarily affecting the skin, and sometimes the nails. It is characterised by the sudden onset of a band-like rash, typically following Blaschko lines. The exact cause of LS is not well established, but it is believed to be an abnormal immune response to the altered keratinocyte clone after a triggering event. Summary: Although nail LS is regarded as rare, it is probably underreported. Single-visualised nail dystrophy, especially partial involvement of the nail, with or without skin rash, should prompt the LS diagnosis among differentials. Onychoscopy might be helpful to better visualise the clinical signs. Nail dystrophy often has a prolonged course even after the resolution of skin lesions. Topical steroids, calcineurin inhibitors, and intralesional steroid injections might be an option for symptomatic patients or for severe and prolonged nail dystrophy. Key Messages: (i) Single nail involvement, nail changes located on one portion of the nail, and the presence of typical linear band-like skin rash should prompt the LS diagnosis. (ii) Onychoscopy might be helpful to better visualise the clinical signs and to avoid unnecessary biopsies. (iii) Nail unit biopsy should be performed if the diagnosis is uncertain to exclude nail involvement of more severe and progressive disease course like nail lichen planus and/or nail unit tumours.
背景：条纹状苔藓（LS）是一种良性皮肤病，多为自限性，主要影响皮肤，有时也会影响指甲。它的特点是突然出现带状皮疹，典型的皮疹呈布拉什科纹。甲沟炎的确切病因尚不明确，但据信是在诱发事件发生后，对改变的角质细胞克隆产生的异常免疫反应。小结：虽然甲沟炎被认为是罕见病，但它可能被低估了。单个可见的甲营养不良，尤其是部分甲受累，伴有或不伴有皮疹，应在鉴别中提示LS诊断。眼底镜检查可能有助于更好地观察临床症状。即使在皮损消退后，甲营养不良症的病程也往往会延长。有症状的患者或病情严重、病程较长的甲营养不良患者可选择外用类固醇激素、钙化蛋白抑制剂和类固醇激素鞘内注射。关键信息：(i) 单个指甲受累、指甲变化位于指甲的一个部分以及出现典型的线状带状皮疹应提示 LS 诊断。(ii)甲状镜检查可能有助于更好地观察临床症状，避免不必要的活组织检查。(iii)如果诊断不确定，应进行甲单位活检，以排除指甲受累的更严重和进行性病程，如甲扁平苔藓和/或甲单位肿瘤。
{"title":"Nail Lichen Striatus and Its Differential Diagnoses","authors":"Aslı Bilgic","doi":"10.1159/000539798","DOIUrl":"https://doi.org/10.1159/000539798","url":null,"abstract":"Background: Lichen striatus (LS) is a benign, mostly self-limiting dermatological condition, primarily affecting the skin, and sometimes the nails. It is characterised by the sudden onset of a band-like rash, typically following Blaschko lines. The exact cause of LS is not well established, but it is believed to be an abnormal immune response to the altered keratinocyte clone after a triggering event. Summary: Although nail LS is regarded as rare, it is probably underreported. Single-visualised nail dystrophy, especially partial involvement of the nail, with or without skin rash, should prompt the LS diagnosis among differentials. Onychoscopy might be helpful to better visualise the clinical signs. Nail dystrophy often has a prolonged course even after the resolution of skin lesions. Topical steroids, calcineurin inhibitors, and intralesional steroid injections might be an option for symptomatic patients or for severe and prolonged nail dystrophy. Key Messages: (i) Single nail involvement, nail changes located on one portion of the nail, and the presence of typical linear band-like skin rash should prompt the LS diagnosis. (ii) Onychoscopy might be helpful to better visualise the clinical signs and to avoid unnecessary biopsies. (iii) Nail unit biopsy should be performed if the diagnosis is uncertain to exclude nail involvement of more severe and progressive disease course like nail lichen planus and/or nail unit tumours.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141831863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annie Jin, Dylan Haynes, Olaf Rodriguez, Ji Hye Park, Nathaniel Jellinek, A. Rubin
Background: A wide variety of tumors can affect the nail unit, with some commonly mistaken as inflammatory or infectious diseases. Obtaining an optimal sample for histopathologic evaluation requires understanding of nail unit anatomy as well as the histopathology of the suspected nail tumor. Summary: This review discusses clinical and histopathologic features of a subset of benign and malignant nail tumors, including subungual melanoma, nail unit squamous cell carcinoma in situ, nail unit squamous cell carcinoma, onychomatricoma, onychopapilloma, onychocytic matricoma, and onychocytic carcinoma. Optimal surgical sampling techniques for each lesion are presented. Key Messages: In summary, the clinical and histopathologic features of several common and rare nail unit tumors and the optimal sampling techniques for each lesion are presented in this manuscript. Knowledge of the clinical and histopathologic features of these tumors informs the surgical approach to them and will produce the best patient outcomes.
{"title":"A Review of the Histopathology of Nail Unit Tumors Including Selection of the Optimal Surgical Sampling","authors":"Annie Jin, Dylan Haynes, Olaf Rodriguez, Ji Hye Park, Nathaniel Jellinek, A. Rubin","doi":"10.1159/000539383","DOIUrl":"https://doi.org/10.1159/000539383","url":null,"abstract":"Background: A wide variety of tumors can affect the nail unit, with some commonly mistaken as inflammatory or infectious diseases. Obtaining an optimal sample for histopathologic evaluation requires understanding of nail unit anatomy as well as the histopathology of the suspected nail tumor. Summary: This review discusses clinical and histopathologic features of a subset of benign and malignant nail tumors, including subungual melanoma, nail unit squamous cell carcinoma in situ, nail unit squamous cell carcinoma, onychomatricoma, onychopapilloma, onychocytic matricoma, and onychocytic carcinoma. Optimal surgical sampling techniques for each lesion are presented. Key Messages: In summary, the clinical and histopathologic features of several common and rare nail unit tumors and the optimal sampling techniques for each lesion are presented in this manuscript. Knowledge of the clinical and histopathologic features of these tumors informs the surgical approach to them and will produce the best patient outcomes.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jane Onyemachi, Caroline Nguyen, Lynchi Nguyen, Olivia Chukwuma, Ayezel Muñoz-Gonzalez
Background: Trichotillomania (TTM), also known as hair pulling disorder, is a chronic disorder that often leads to considerable emotional distress and functional impairment in affected individuals. Despite the strong underlying psychiatric component of TTM, the majority of individuals suffering from TTM initially may present to dermatologists because of their hair loss. This necessitates awareness and early recognition of TTM as well as familiarity with the unique considerations for its management. Summary: This study reviews the limited literature regarding quality of life in TTM, the methodologies employed to assess quality of life, and further explores the necessity of an interdisciplinary clinical approach to treatment. Several studies included in this review demonstrated the significant degree to which TTM reduces quality of life. Multiple treatment modalities for TTM have been successfully used in the literature that incorporate a comprehensive approach to management and ultimately address the underlying psychiatric component of TTM. Key Messages: TTM significantly reduces the quality of life in affected individuals. Successful management of TTM requires an interdisciplinary approach that bridges dermatology and psychiatry. Screening tools that assess the impact of TTM on quality of life are clinically useful and essential for early diagnosis and optimal management.
{"title":"Bridging the Gap between Dermatology and Psychiatry: A Review on Quality of Life in Trichotillomania and Special Considerations in Management","authors":"Jane Onyemachi, Caroline Nguyen, Lynchi Nguyen, Olivia Chukwuma, Ayezel Muñoz-Gonzalez","doi":"10.1159/000539563","DOIUrl":"https://doi.org/10.1159/000539563","url":null,"abstract":"Background: Trichotillomania (TTM), also known as hair pulling disorder, is a chronic disorder that often leads to considerable emotional distress and functional impairment in affected individuals. Despite the strong underlying psychiatric component of TTM, the majority of individuals suffering from TTM initially may present to dermatologists because of their hair loss. This necessitates awareness and early recognition of TTM as well as familiarity with the unique considerations for its management. Summary: This study reviews the limited literature regarding quality of life in TTM, the methodologies employed to assess quality of life, and further explores the necessity of an interdisciplinary clinical approach to treatment. Several studies included in this review demonstrated the significant degree to which TTM reduces quality of life. Multiple treatment modalities for TTM have been successfully used in the literature that incorporate a comprehensive approach to management and ultimately address the underlying psychiatric component of TTM. Key Messages: TTM significantly reduces the quality of life in affected individuals. Successful management of TTM requires an interdisciplinary approach that bridges dermatology and psychiatry. Screening tools that assess the impact of TTM on quality of life are clinically useful and essential for early diagnosis and optimal management.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: This article presents a case of nail unit melanoma (NUM), highlighting the unusual clinical presentations as those originating from the hyponychium. We discuss how dermoscopy is an essential tool for this pigmented lesion, and how the lack of a standardized guide for NUM underscores the importance of personalized approaches to ensure the best possible outcomes. Case Presentation: A 72-year-old woman presented with a melanocytic lesion on her right second finger, characterized by a hyperpigmented macule with irregular borders and a heterogeneous distribution of pigment. Biopsy confirmed acral lentiginous melanoma. Nail unit was exercised with a 5-mm margin toward the hyponychium. Conclusion: NUM is the predominant variant of malignant melanoma in certain ethnic groups and is influenced by factors such as trauma and chronic inflammation rather than sun exposure. Despite its higher incidence in areas like the great toe and thumb, NUM in the hyponychium is rare. Detection and treatment require thorough examination and individualized surgical approaches. Conservative surgeries may preserve limb function without compromising survival rates. Early detection remains challenging and necessitates attention to patient concerns and potential signs of melanoma.
导言：本文介绍了一例甲单位黑色素瘤（NUM）病例，突出强调了该病例不同寻常的临床表现，即源自甲下的黑色素瘤。我们讨论了皮肤镜如何成为治疗这种色素性病变的重要工具，以及缺乏针对 NUM 的标准化指南如何凸显了个性化方法对确保最佳治疗效果的重要性。病例介绍：一名 72 岁的妇女因右手二指上的黑色素细胞病变而就诊，病变为色素沉着斑，边界不规则，色素分布不均。活检证实为尖头皮样黑色素瘤。对指甲进行了切除，并向骨下切除了 5 毫米的边缘。结论：NUM是某些种族群体中恶性黑色素瘤的主要变种，受外伤和慢性炎症等因素的影响，而非阳光照射。尽管大脚趾和拇指等部位的 NUM 发病率较高，但颌骨下的 NUM 却十分罕见。检测和治疗需要彻底检查和个性化的手术方法。保守手术可在不影响存活率的情况下保留肢体功能。早期检测仍具有挑战性，需要关注患者的疑虑和黑色素瘤的潜在征兆。
{"title":"Nail Unit Melanoma: Uncommon Presentations to Keep in Mind","authors":"Fanny Carolina López-Jiménez, Alejandra Michel-Avalos, Judith Guadalupe Domíguez-Cherit, Judith Monserrat Corona-Herrera","doi":"10.1159/000539747","DOIUrl":"https://doi.org/10.1159/000539747","url":null,"abstract":"Introduction: This article presents a case of nail unit melanoma (NUM), highlighting the unusual clinical presentations as those originating from the hyponychium. We discuss how dermoscopy is an essential tool for this pigmented lesion, and how the lack of a standardized guide for NUM underscores the importance of personalized approaches to ensure the best possible outcomes. Case Presentation: A 72-year-old woman presented with a melanocytic lesion on her right second finger, characterized by a hyperpigmented macule with irregular borders and a heterogeneous distribution of pigment. Biopsy confirmed acral lentiginous melanoma. Nail unit was exercised with a 5-mm margin toward the hyponychium. Conclusion: NUM is the predominant variant of malignant melanoma in certain ethnic groups and is influenced by factors such as trauma and chronic inflammation rather than sun exposure. Despite its higher incidence in areas like the great toe and thumb, NUM in the hyponychium is rare. Detection and treatment require thorough examination and individualized surgical approaches. Conservative surgeries may preserve limb function without compromising survival rates. Early detection remains challenging and necessitates attention to patient concerns and potential signs of melanoma.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caitlyn B. Dagenet, D. De, T. Shih, Brindley Brooks, Denise Fixsen, Sarah Park, Khiem A. Tran, Jennifer L. Hsiao, Vivian Y Shi
Introduction: The Hurley staging system is a grading system utilized to measure hidradenitis suppurativa (HS) severity. Teaching patients to grade the severity of HS may aid in the accuracy of self-reporting for research and clinical purposes. Thus, this study aimed to determine the utility of a Hurley stage learning module (HSLM) for participants to grade images of HS. Methods: An anonymous survey was distributed online between October 2021 and January 2022. Participants completed a 5-min HSLM and a 9-item Hurley staging quiz with varying Fitzpatrick skin tones and HS severity. Comparative statistics were completed using t tests. p value of <0.05 was considered significant. Results: Majority of participants were female (95.2%, 263/276) and white (81.5%, 225/276). In terms of the percentage of quiz questions correct: 77.9% of respondents graded the Hurley stage 1 images correctly, 79.3% for Hurley stage 2, and 100% for Hurley stage 3. There was a significant difference in confidence of rating Hurley stage for any image (3.66 ± 1.18 vs. 4.39 ± 0.83; p < 0.0001) and own Hurley stage (3.90 ± 1.19 vs. 4.54 ± 0.81; p < 0.0001) pre- and post-HSLM. Conclusion: An HSLM provides high level of accuracy and increased participant confidence to grade their own disease and images of HS. An HSLM is an effective, cost-efficient, and valuable tool to facilitate clinical and survey research by allowing patients to report disease severity with increased confidence.
{"title":"Hurley Staging Training for Hidradenitis Suppurativa Patients","authors":"Caitlyn B. Dagenet, D. De, T. Shih, Brindley Brooks, Denise Fixsen, Sarah Park, Khiem A. Tran, Jennifer L. Hsiao, Vivian Y Shi","doi":"10.1159/000539746","DOIUrl":"https://doi.org/10.1159/000539746","url":null,"abstract":"Introduction: The Hurley staging system is a grading system utilized to measure hidradenitis suppurativa (HS) severity. Teaching patients to grade the severity of HS may aid in the accuracy of self-reporting for research and clinical purposes. Thus, this study aimed to determine the utility of a Hurley stage learning module (HSLM) for participants to grade images of HS. Methods: An anonymous survey was distributed online between October 2021 and January 2022. Participants completed a 5-min HSLM and a 9-item Hurley staging quiz with varying Fitzpatrick skin tones and HS severity. Comparative statistics were completed using t tests. p value of <0.05 was considered significant. Results: Majority of participants were female (95.2%, 263/276) and white (81.5%, 225/276). In terms of the percentage of quiz questions correct: 77.9% of respondents graded the Hurley stage 1 images correctly, 79.3% for Hurley stage 2, and 100% for Hurley stage 3. There was a significant difference in confidence of rating Hurley stage for any image (3.66 ± 1.18 vs. 4.39 ± 0.83; p < 0.0001) and own Hurley stage (3.90 ± 1.19 vs. 4.54 ± 0.81; p < 0.0001) pre- and post-HSLM. Conclusion: An HSLM provides high level of accuracy and increased participant confidence to grade their own disease and images of HS. An HSLM is an effective, cost-efficient, and valuable tool to facilitate clinical and survey research by allowing patients to report disease severity with increased confidence.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Lichen planopilaris (LPP) is a primary lymphocytic cicatricial alopecia characterized by several different patterns of permanent hair loss. Summary: Trichoscopy plays an essential role in the context of LPP, as recognizing the distinctive signs of the disease facilitates the diagnosis of all forms of lichenoid alopecia. Key Messages: This review aimed to recognizing the trichoscopic signs early on, enabling timely intervention, potentially preventing the disease from advancing to its permanent scarring stage.
{"title":"Lichen Planopilaris Trichoscopy in Caucasian Scalp: A Review","authors":"Gloria Orlando, Luca Rapparini, Francesca Bruni","doi":"10.1159/000539848","DOIUrl":"https://doi.org/10.1159/000539848","url":null,"abstract":"Background: Lichen planopilaris (LPP) is a primary lymphocytic cicatricial alopecia characterized by several different patterns of permanent hair loss. Summary: Trichoscopy plays an essential role in the context of LPP, as recognizing the distinctive signs of the disease facilitates the diagnosis of all forms of lichenoid alopecia. Key Messages: This review aimed to recognizing the trichoscopic signs early on, enabling timely intervention, potentially preventing the disease from advancing to its permanent scarring stage.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. D. Sánchez-Cárdenas, Gustavo Antolín Silva Flores, T. Mendoza Ibarra, Laura Contreras Jimenez, R. M. Guevara Castillo, N. Pulido Díaz, Roberto G. Arenas, Gabriela Moreno Coutiño, E. Haneke
Introduction: Several infectious diseases can present nail manifestations, which may be useful for diagnosis and prognosis, and only a few reports have been made regarding monkeypox (mpox). The objective of this study was to describe the clinical characteristics of nail alterations in patients living with HIV coinfected with mpox. Methods: A prospective, cross-sectional study included patients living with HIV/AIDS, coinfected with mpox. We examined all 20 nails in search of nail plate alterations. Patients were divided into two groups, with and without nail disease, and the CD4 count was noted according to the Centers for Disease Control and Prevention (CDC) classification. A χ2 or Fisher’s exact test for qualitative variables and Mann-Whitney U and Kruskal-Wallis tests with post hoc Bonferroni test for quantitative variables were used to compare them. Data were analyzed with the SPSS Statistics 25 software. Results: Sixty-nine patients were included. The frequency of nail involvement was 58%. Papulonodular lesions were the most frequent type identified, with 21 cases (30.4%). A significant difference was observed between patients with nail disease versus median CD4 count (160 vs. 700/mm3; p = 0.002) and median HIV viral load (45,000 vs. 900/mL; p = 0.009). When comparing the characteristics of the nail lesions with the CDC Classification System for HIV infection by the CD4 count, a significant difference was observed in foot involvement, splinter hemorrhages, papulo-nodular lesions, anonychia, onychomadesis, acute paronychia, and nail bed ulcer-atrophy (p < 0.05). Conclusions: The frequency of nail lesions is high in patients living with HIV coinfected with mpox. In addition, they tend to be more destructive in patients with lower CD4 counts and higher viral loads.
{"title":"Nail Disorders in Patients Living with HIV Coinfected with Monkeypox: A Clinical Study in 69 Mexican Cases","authors":"C. D. Sánchez-Cárdenas, Gustavo Antolín Silva Flores, T. Mendoza Ibarra, Laura Contreras Jimenez, R. M. Guevara Castillo, N. Pulido Díaz, Roberto G. Arenas, Gabriela Moreno Coutiño, E. Haneke","doi":"10.1159/000539761","DOIUrl":"https://doi.org/10.1159/000539761","url":null,"abstract":"Introduction: Several infectious diseases can present nail manifestations, which may be useful for diagnosis and prognosis, and only a few reports have been made regarding monkeypox (mpox). The objective of this study was to describe the clinical characteristics of nail alterations in patients living with HIV coinfected with mpox. Methods: A prospective, cross-sectional study included patients living with HIV/AIDS, coinfected with mpox. We examined all 20 nails in search of nail plate alterations. Patients were divided into two groups, with and without nail disease, and the CD4 count was noted according to the Centers for Disease Control and Prevention (CDC) classification. A χ2 or Fisher’s exact test for qualitative variables and Mann-Whitney U and Kruskal-Wallis tests with post hoc Bonferroni test for quantitative variables were used to compare them. Data were analyzed with the SPSS Statistics 25 software. Results: Sixty-nine patients were included. The frequency of nail involvement was 58%. Papulonodular lesions were the most frequent type identified, with 21 cases (30.4%). A significant difference was observed between patients with nail disease versus median CD4 count (160 vs. 700/mm3; p = 0.002) and median HIV viral load (45,000 vs. 900/mL; p = 0.009). When comparing the characteristics of the nail lesions with the CDC Classification System for HIV infection by the CD4 count, a significant difference was observed in foot involvement, splinter hemorrhages, papulo-nodular lesions, anonychia, onychomadesis, acute paronychia, and nail bed ulcer-atrophy (p < 0.05). Conclusions: The frequency of nail lesions is high in patients living with HIV coinfected with mpox. In addition, they tend to be more destructive in patients with lower CD4 counts and higher viral loads.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141835787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sera Nur Yücesoy, Tumay Ak, Sena Öner, S. Serdaroğlu
Introduction: Recent studies showed that antimicrobial peptides have an essential role in the pathogenesis of acne vulgaris. This study aims to investigate serum catestatin levels in acne vulgaris patients and focuses on the change in serum levels after systemic isotretinoin therapy. Methods: This prospective study includes 101 acne vulgaris patients and 28 healthy controls. Serum catestatin levels were measured and compared between acne vulgaris and control group patients. Also, serum catestatin levels were measured again at the 24th week of isotretinoin therapy. Results: The serum catestatin levels in patients with acne vulgaris were statistically higher than in the control group (p < 0.001). In addition, serum catestatin levels were associated with the severity of acne vulgaris. A significant decrease in serum catestatin levels was detected after 24 weeks of systemic isotretinoin treatment. Conclusion: Catestatin was found to be significantly higher in the serum of patients with acne vulgaris compared to the control group. Although, the demonstration that catestatin levels decrease with isotretinoin treatment may indicate that it may have an important role in the pathogenesis of acne and could be used as a biomarker, future studies are needed to establish the role of catestatin in the pathogenesis of acne vulgaris.
{"title":"Serum Catestatin Levels in Patients with Acne Vulgaris: Single-Center Prospective Study","authors":"Sera Nur Yücesoy, Tumay Ak, Sena Öner, S. Serdaroğlu","doi":"10.1159/000539224","DOIUrl":"https://doi.org/10.1159/000539224","url":null,"abstract":"Introduction: Recent studies showed that antimicrobial peptides have an essential role in the pathogenesis of acne vulgaris. This study aims to investigate serum catestatin levels in acne vulgaris patients and focuses on the change in serum levels after systemic isotretinoin therapy. Methods: This prospective study includes 101 acne vulgaris patients and 28 healthy controls. Serum catestatin levels were measured and compared between acne vulgaris and control group patients. Also, serum catestatin levels were measured again at the 24th week of isotretinoin therapy. Results: The serum catestatin levels in patients with acne vulgaris were statistically higher than in the control group (p < 0.001). In addition, serum catestatin levels were associated with the severity of acne vulgaris. A significant decrease in serum catestatin levels was detected after 24 weeks of systemic isotretinoin treatment. Conclusion: Catestatin was found to be significantly higher in the serum of patients with acne vulgaris compared to the control group. Although, the demonstration that catestatin levels decrease with isotretinoin treatment may indicate that it may have an important role in the pathogenesis of acne and could be used as a biomarker, future studies are needed to establish the role of catestatin in the pathogenesis of acne vulgaris.","PeriodicalId":21844,"journal":{"name":"Skin Appendage Disorders","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141360391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Stefanis, Petr Arenberger, M. Arenbergerová, Dimitris Rigopoulos
Introduction: Androgenetic alopecia (AGA) is the most common type of hair loss. Platelet-rich plasma (PRP) and mesotherapy (MZT) injections of various solutions fortified with growth factors are popular treatment options for AGA. The aim of this study was to compare the efficacy of RPP and MZT products in the treatment of AGA. Methods: This retrospective study included 72 AGA patients treated with two PRP formulations and two MZT products, administered manually or with a gun injector. Hair parameters (hair thickness, hair density, and hair count) on frontal and vertex areas were measured before and after 6 months. Results: Over 6 months, trichoscopic parameters showed significant intragroup and intergroup variability. MZT1 and PRP2 groups exhibited statistically significant improvement in most parameters, while MZT2 significantly increased vertex hair density. Hair thickness changes differed significantly between PRP1 and PRP2 groups (unadjusted p value <0.001) and possibly between MZT1 and PRP1 groups (unadjusted p value = 0.049) in both regions. Discussion: Injections of PRP and MZT formulations can significantly enhance trichoscopic parameters in AGA patients within a 6-month period, but the extent of improvement varies among different PRP and MZT products.
简介：雄激素性脱发（AGA）是最常见的脱发类型：雄激素性脱发（AGA）是最常见的脱发类型。富血小板血浆（PRP）和中胚层疗法（MZT）注射各种含有生长因子的溶液是治疗 AGA 的流行疗法。本研究旨在比较 RPP 和 MZT 产品治疗 AGA 的疗效。方法：这项回顾性研究包括 72 位接受两种 PRP 制剂和两种 MZT 产品治疗的 AGA 患者，他们均采用手动或枪式注射器进行注射。在治疗前和治疗后 6 个月测量了前额和头顶部位的毛发参数（毛发厚度、毛发密度和毛发数量）。结果显示在 6 个月内，毛发参数在组内和组间都有显著差异。MZT1 组和 PRP2 组在大多数参数上都有统计学意义上的显著改善，而 MZT2 组则显著增加了顶点毛发密度。PRP1 组和 PRP2 组之间的毛发厚度变化有明显差异（未调整的 p 值 <0.001），MZT1 组和 PRP1 组之间的毛发厚度变化也可能有差异（未调整的 p 值 = 0.049）。讨论注射 PRP 和 MZT 制剂可在 6 个月内显著改善 AGA 患者的三镜面参数，但不同 PRP 和 MZT 产品的改善程度各不相同。
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