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2022 IEEE 35th International Symposium on Computer-Based Medical Systems (CBMS)最新文献

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A secure architecture for exploring patient-level databases from distributed institutions 用于从分布式机构中探索患者级数据库的安全体系结构
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00086
João Rafael Almeida, J. Barraca, J. L. Oliveira
One of the main goals of clinical studies consists of identifying diseases' causes and improving the efficacy of medical treatments. Sometimes, the reduced number of participants is a limiting factor for these studies, leading researchers to organise multi-centre studies. However, sharing health data raises certain concerns regarding patients' privacy, namely related to the robustness of anonymisation procedures. Although these techniques remove personal identifiers from registries, some studies have shown that anonymisation procedures can sometimes be reverted using specific patients' characteristics. In this paper, we propose a secure architecture to explore distributed databases without compromising the patient's privacy. The proposed architecture is based on interoperable repositories supported by a common data model.
临床研究的主要目标之一是确定疾病的病因,提高医学治疗的效果。有时,参与者数量的减少是这些研究的一个限制因素,导致研究人员组织多中心研究。然而,共享健康数据引起了对患者隐私的某些担忧,即与匿名程序的稳健性有关。虽然这些技术从注册表中删除了个人标识符,但一些研究表明,有时可以使用特定患者的特征来恢复匿名程序。在本文中,我们提出了一种安全架构来探索分布式数据库,而不损害患者的隐私。所建议的体系结构基于由公共数据模型支持的可互操作存储库。
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引用次数: 2
Predicting the Onset of Delirium on Hourly Basis in an Intensive Care Unit Following Cardiac Surgery 心脏手术后重症监护病房每小时谵妄发作的预测
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00048
L. Lapp, M. Roper, K. Kavanagh, S. Schraag
Delirium, affecting up to 52% of cardiac surgery patients, can have serious long-term effects on patients by damaging cognitive ability and causing subsequent functional decline. This study reports on the development and evaluation of predictive models aimed at identifying the likely onset of delirium on an hourly basis in intensive care unit following cardiac surgery. Most models achieved a mean AUC > 0.900 across all lead times. A support vector machine achieved the highest performance across all lead times of AUC = 0.941 and Sensitivity = 0.907, and BARTm, where missing values were replaced with missForest imputation, achieved the highest Specificity of 0.892. Being able to predict delirium hours in advance gives clinicians the ability to intervene and optimize treatments for patients who are at risk and avert potentially serious and life-threatening consequences.
谵妄影响了多达52%的心脏手术患者,它会损害患者的认知能力并导致随后的功能衰退,从而对患者产生严重的长期影响。本研究报告了预测模型的发展和评估,旨在确定心脏手术后重症监护病房每小时可能发生的谵妄。大多数型号在所有交货期的平均AUC > 0.900。支持向量机在所有提前期内获得了最高的性能,AUC = 0.941,灵敏度= 0.907,而用misforest imputation代替缺失值的BARTm获得了最高的特异性0.892。能够提前数小时预测谵妄,使临床医生能够对处于危险中的患者进行干预和优化治疗,避免潜在的严重和危及生命的后果。
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引用次数: 1
Facial Pore Segmentation Algorithm using Shallow CNN 基于浅CNN的面部毛孔分割算法
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00062
Sunyong Seo, S. Yoo, Semin Kim, Daeun Yoon, Jonghan Lee
Poresare minute skin openings through which hair and sebum come out and appear as holes in the facial skin. Enlarged pore is one of the major concerns for people who care about their skin. Remedies include the use of cosmetics and pore-reduction medical procedures. Awareness of the condition of one's facial pores and appropriate management are required to prevent pore deterioration. Pore segmentation algorithms based on classical image processing are characterized by low accuracy and high computational costs. In addition, these algorithms require that input images be taken in light-controlled environments. These issues were resolved by using a light-specialized data augmentation method and a neural network with a narrow receptive field for identifying local features. We introduce Pore-Net, an algorithm that can be used on mobile devices to segment pores with a low computational cost, using selfie-camera images as an input. Pore-Net has the following algorithm flow. First, a confidence map-based segmentation without encoder-decoder form is applied to lower the computational costs on high-resolution input images. Second, pre- and post-processing for input based on region-of-interest(ROI) of facial landmarks are performed to work robustly in mobile devices. Pore-Net achieved the lowest computational cost in inference time and multiply-and-accumulates(MACs) when compared with the binary segmentation models with similar performance in intersection-over-union(IoU).
毛孔是皮肤上细小的开口,毛发和皮脂通过这些开口出来,在面部皮肤上形成孔洞。毛孔粗大是关心皮肤的人最关心的问题之一。补救措施包括使用化妆品和减少毛孔的医疗程序。意识到一个人的面部毛孔状况和适当的管理是必要的,以防止毛孔恶化。基于经典图像处理的孔隙分割算法具有精度低、计算量大的特点。此外,这些算法要求在光控环境中拍摄输入图像。这些问题都是通过使用光专业化的数据增强方法和具有窄接受域的神经网络来识别局部特征来解决的。我们介绍了Pore-Net,这是一种可以在移动设备上使用的算法,使用自拍照图像作为输入,以较低的计算成本分割毛孔。Pore-Net的算法流程如下。首先,采用基于置信度图的非编解码器分割,降低了高分辨率输入图像的计算成本。其次,基于感兴趣区域(ROI)对输入进行预处理和后处理,使其在移动设备上稳健性地工作。与具有相似性能的二元分割模型相比,Pore-Net在推理时间和乘法累积(mac)方面的计算成本最低。
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引用次数: 1
Study of Vocal Muscle Strain with Skin Deformation Tracking System 皮肤变形跟踪系统对声带肌肉劳损的研究
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00026
S. Hogue, Adrianna C. Shembel, X. Guo
Vocal strain can have a profound effect on a person's life and livelihood. However, methods to identify and quantify vocal strain presumed to originate in the laryngeal muscles severely lack. We aim to address this shortcoming. Using motion capture with consumer RGBD cameras, we track skin deformation of perilaryngeal anterior neck regions in participants with and without vocal strain. Neck movement variability differences between the two groups provides insight into extrinsic laryngeal vocal muscles that may underlie symptoms of vocal strain.
声音紧张会对一个人的生活和生计产生深远的影响。然而,识别和量化被认为起源于喉部肌肉的声带劳损的方法严重缺乏。我们的目标是解决这个缺点。使用消费者RGBD相机的动作捕捉,我们跟踪有和没有声音紧张的参与者的咽周围前颈部区域的皮肤变形。两组之间颈部运动变异性的差异提供了对喉外发声肌肉的深入了解,这可能是发声劳损症状的基础。
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引用次数: 0
Subgroup Discovery Analysis of Treatment Patterns in Lung Cancer Patients 肺癌患者治疗方式的亚组发现分析
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00082
Daniel Gómez-Bravo, Aaron García, Guillermo Vigueras, Belén Ríos-Sánchez, B. Otero, R. López, M. Torrente, Ernestina Menasalvas Ruiz, M. Provencio, A. R. González
Lung cancer is the leading cause of cancer death. More than 236,740 new cases of lung cancer patients are expected in 2022, with an estimation of more than 130,180 deaths. Improving the survival rates or the patient's quality of life is partially covered by a common element: treatments. Cancer treatments are well known for the toxic outcomes and secondary effects on the patients. These toxicities cause different health problems that impact the patient's quality of life. Reducing toxicities without a decline on the positive survival effect is an important goal that aims to be pursued from the clinical perspective. On the other hand, clinical guidelines include general knowl-edge about cancer treatment recommendations to assist clinicians. Although they provide treatment recommendations based on cancer disease aspects and individual patient features, a statistical analysis taking into account treatment outcomes is not provided here. Therefore, the comparison between clinical guidelines with treatment patterns found in clinical data, would allow to validate the patterns found, as well as discovering alternative treatment patterns. In this work, we have analyzed a dataset containing lung cancer patients information including patients' data, prescribed treatments and outcomes obtained. Using a Subgroup Discovery method we identify patterns based on cancer stage while relying on treatment outcomes. Results are compared with clinical guide-lines and analyzed based on statistical and medical relevance using Subgroup Discovery metrics.
肺癌是癌症死亡的主要原因。到2022年,预计将有超过236740例肺癌新病例,估计死亡人数将超过130180人。提高生存率或病人的生活质量部分是由一个共同因素所覆盖的:治疗。众所周知,癌症治疗的毒性结果和对患者的继发性影响。这些毒性会引起不同的健康问题,影响患者的生活质量。降低毒副作用而不降低阳性生存效应是临床努力追求的重要目标。另一方面,临床指南包括癌症治疗建议的一般知识,以协助临床医生。虽然他们提供了基于癌症疾病方面和个体患者特征的治疗建议,但没有提供考虑到治疗结果的统计分析。因此,临床指南与临床数据中发现的治疗模式之间的比较,将允许验证所发现的模式,以及发现替代的治疗模式。在这项工作中,我们分析了一个包含肺癌患者信息的数据集,包括患者数据、处方治疗和获得的结果。使用亚组发现方法,我们根据治疗结果确定基于癌症阶段的模式。将结果与临床指南进行比较,并使用亚组发现指标基于统计学和医学相关性进行分析。
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引用次数: 2
A goal-driven approach for clinical decision conflict detection and its application to the treatment of multimorbidity 目标驱动的临床决策冲突检测方法及其在多病治疗中的应用
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00035
Yunlong Ye, Liang Xiao
The treatment of patients with multimorbidity has always been a matter of importance. Due to the complexity of patients' conditions, physicians need to consider not only the cumbersome consultation process and complex care plans., but also potential clinical decision conflicts between different diseases. Currently, most clinical guidelines focus on a single medical condition, and the emergent and random nature of illness in patients with multiple conditions makes it difficult to take good account of the potential conflicts between various clinical decisions. Current clinical decision models on the treatment of complications are limited to specific types of complications and usually detect conflicts in a declarative method, which is difficult to cover various types of clinical decision conflicts and is not scalable. We model the treatment process of patients with multimorbidity as a goal forest and propose a goal-driven clinical support model for group decision making. This model is applicable to distributed settings and can integrate multiple clinical guidelines to concurrently treat patients with multimorbidity. A clinical decision conflict ontology is constructed that defines various decision conflict types for clinical decision conflict detection, and providing solutions for conflict resolution.
多病患者的治疗一直是一个重要的问题。由于患者病情的复杂性,医生不仅需要考虑繁琐的咨询过程和复杂的护理计划。,而且不同疾病之间潜在的临床决策冲突。目前,大多数临床指南都侧重于单一的医疗状况,而患者的疾病具有多种情况的突发性和随机性,这使得很难很好地考虑到各种临床决策之间的潜在冲突。目前关于并发症治疗的临床决策模型仅限于特定类型的并发症,通常采用声明式方法检测冲突,难以涵盖各种类型的临床决策冲突,且不具有可扩展性。我们将多病患者的治疗过程建模为一个目标森林,并提出了一个目标驱动的群体决策临床支持模型。该模型适用于分布式环境,可以整合多种临床指南,同时治疗多病患者。构建了临床决策冲突本体,定义了临床决策冲突的各种类型,为临床决策冲突检测提供了解决方案。
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引用次数: 0
Prediction of declining engagement to self-monitoring apps on the example of tinnitus mHealth data 以耳鸣移动健康数据为例,预测自我监测应用的参与度会下降
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00047
Miro Schleicher, Sebastian Hamacher, Mats Naujoks, Kolja Günther, Timo Schmidt, R. Pryss, Johannes Schobel, W. Schlee, M. Spiliopoulou
Applications in mobile health (mHealth) empower self-monitoring of chronic conditions of the user and also offer insights to medical experts. The data generated by these apps constitute one time series per user. These time series vary substantially in length and contain ‘gaps’, as users pause or stop interacting with the app. In order to design measures that promote patient engagement with the app, it is necessary to predict and understand decline in engagement. We measured the performance of the algorithms on two real-world datasets from an mHealth app. We show that all approaches outperform the baseline and that shapelet, dictionary and matrix distance approach perform similarly for long-term prediction. This is particularly important because it allows early intervention towards increase of engagement. In this paper, we present an approach that uses the missingness information to process time series with large gaps.
移动医疗(mHealth)中的应用程序使用户能够自我监测慢性疾病,并为医学专家提供见解。这些应用程序生成的数据构成每个用户的一个时间序列。这些时间序列在长度上有很大差异,并且包含“间隙”,因为用户暂停或停止与应用程序交互。为了设计促进患者参与应用程序的措施,有必要预测和理解参与度的下降。我们在来自移动健康应用程序的两个真实世界数据集上测量了算法的性能。我们表明,所有方法都优于基线,并且shapelet,字典和矩阵距离方法在长期预测方面表现相似。这一点尤其重要,因为它允许早期干预以提高参与度。本文提出了一种利用缺失信息处理大间隙时间序列的方法。
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引用次数: 1
Integrating with Segmentation by Using Multi-Task Learning Improves Classification Performance in Medical Image Analysis 将多任务学习与分割相结合,提高了医学图像分析的分类性能
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00069
Yi Li, Yuanyuan Zhao, Mingyu Wang, Fei Li, Jia Chen, Yanji Luo, S. Feng, Xiaoyi Lin, Bingsheng Huang
Diagnosis of tumors is an important direction of computer-aided diagnosis (CAD). The shape, size, and boundary of the tumor are widely-used diagnostic evidence, and the corresponding segmentation annotated by the radiologists is a vital expert knowledge, which can be used as supervision to guide feature extraction. Therefore, this study firstly introduces a multi-task learning (MTL) network integrating segmentation task for predicting grading of pancreatic neuroendocrine neoplasms (pNENs) and the microvascular invasion (MVI) of hepatocellular carcinoma (HCC). The proposed network combines a powerful split-attention-based encoder and a U-net decoder, and achieves the best performance in comparisons of other popular networks and previous studies. In addition, feature map visualization suggests that the reason for the improved classification performance may be that MTL makes the encoder pay more attention to lesions and extract more semantic information.
肿瘤诊断是计算机辅助诊断(CAD)的一个重要方向。肿瘤的形状、大小和边界是广泛使用的诊断依据,放射科医师标注的相应分割是至关重要的专家知识,可以作为指导特征提取的监督。因此,本研究首先引入一种整合分割任务的多任务学习(MTL)网络,用于预测胰腺神经内分泌肿瘤(pNENs)的分级和肝细胞癌(HCC)的微血管侵袭(MVI)。该网络结合了一个强大的基于分散注意力的编码器和一个U-net解码器,与其他流行的网络和先前的研究相比,取得了最好的性能。此外,特征图可视化表明,分类性能提高的原因可能是MTL使编码器更加关注病灶,提取更多的语义信息。
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引用次数: 0
Hyperparameter for Deep Learning Applied in Mammogram Image Classification 超参数深度学习在乳房x光图像分类中的应用
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00023
J. Pereira, M. X. Ribeiro
Deep Learning has become increasingly frequent in the studies and analysis of medical images. Advances relevant to this area of research improve computer-aided diagnostic systems and help physicians' routine when providing a second opinion. Breast cancer is one of the types most common cancer among women worldwide. Early diagnosis of breast cancer can facilitate treatment and help saves lives. Mammography is the most widely used exam in the clinical routine to diagnose breast cancer. The analysis of the mammogram requires a specialist with experience in medical imaging. Deep Learning and Machine Learning techniques can collaborate computationally with this task. Adapting the hyperparameters provided to deep learning architectures helps improve the results in analyzing and classifying mammogram images. This paper presents a deep learning-based approach to classifying mammogram image regions of interest (ROIs). This approach includes transfer learning, hyperparameter and fine-tuning, and an ensemble with the models that showed the best results. The process demonstrated promising results, with the ensemble reaching 92% accuracy in the classification of mammogram ROIs of the test set and the area under the curve (AUC) value of 0.97 for the best model.
深度学习在医学图像的研究和分析中越来越频繁。这一研究领域的进展改进了计算机辅助诊断系统,并在提供第二意见时帮助医生的日常工作。乳腺癌是全世界女性中最常见的癌症之一。乳腺癌的早期诊断有助于治疗和挽救生命。乳房x光检查是临床上诊断乳腺癌最广泛使用的常规检查。乳房x光片的分析需要有医学成像经验的专家。深度学习和机器学习技术可以在计算上协同完成这项任务。将提供的超参数应用于深度学习架构有助于改善乳房x光图像的分析和分类结果。本文提出了一种基于深度学习的乳房x光图像感兴趣区域(roi)分类方法。该方法包括迁移学习、超参数和微调,以及与显示最佳结果的模型的集成。该过程显示了令人满意的结果,集合在测试集的乳房x线照片roi分类中准确率达到92%,最佳模型的曲线下面积(AUC)值为0.97。
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引用次数: 0
MRI-guided Automated Delineation of Gross Tumor Volume for Nasopharyngeal Carcinoma using Deep Learning mri引导下使用深度学习自动描绘鼻咽癌大体肿瘤体积
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00058
Meiyan Yue, Z. Dai, Jiahui He, Yaoqin Xie, N. Zaki, Wenjian Qin
In this paper, we propose a novel deep learning-based automatic delineation method of nasopharynx gross tumor volume (GTVnx) by combing computed tomography (CT) and magnetic resonance imaging (MRI) modalities. The purpose of this study is to explore whether MRI can provide additional information to improve the accuracy of delineation on CT. The proposed model can adaptively leverage the high contrast information of MRI into the automated delineation of GTVnx on CT in nasopharyngeal carcinoma (NPC) radiotherapy. In this study, the dataset collected from 192 patients with NPC was used to verify the performance of the proposed method. The average Dice Similarity Coefficient, 95% Hausdorff Distance and Average Symmetric Surface Distance of the segmentation results predicted by the proposed model are 0.7181, 9.6637mm, and 2.8014mm, respectively, which outperformed that of the single-modal and the concatenation-based multi-modal segmentation models.
本文提出了一种结合计算机断层扫描(CT)和磁共振成像(MRI)的基于深度学习的鼻咽部总肿瘤体积(GTVnx)自动描绘方法。本研究的目的是探讨MRI是否可以提供额外的信息,以提高CT上圈定的准确性。该模型可以自适应地利用MRI的高对比度信息,在鼻咽癌放疗的CT上自动描绘GTVnx。在这项研究中,收集了192例鼻咽癌患者的数据集来验证所提出方法的性能。该模型预测的分割结果的平均骰子相似系数、95% Hausdorff距离和平均对称表面距离分别为0.7181、9.6637和2.8014mm,优于单模态和基于连接的多模态分割模型。
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引用次数: 0
期刊
2022 IEEE 35th International Symposium on Computer-Based Medical Systems (CBMS)
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