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2022 IEEE 35th International Symposium on Computer-Based Medical Systems (CBMS)最新文献

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Investigating the Effectiveness of Color Coding in Multimodal Medical Imaging 彩色编码在多模态医学成像中的有效性研究
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00054
G. Placidi, G. Castellano, F. Mignosi, M. Polsinelli, G. Vessio
In medical imaging, images represent the quantification of the interaction between electromagnetic waves and our body and are represented in grey-scale. In addition, medical imaging often produces multimodal images. However, the analysis and interpretation of these images mostly occur in sequence or, as in the case of automatic tools, they are simply concatenated as independent sources of information. In both cases, color perception and color contrast are not exploited. Color perception and color contrast play a crucial role in human vision to recognize objects effectively and efficiently, and this can in principle extend to automatic systems. In this paper we show how color coding, particularly using color opponent models, can become an effective tool for preliminary color-based segmentation. Tests have been conducted on multimodal Magnetic Resonance Imaging (MRI) of the brain collected in a public database and the results obtained show the importance of color coding in medical imaging analysis.
在医学成像中,图像代表了电磁波与我们身体之间相互作用的量化,并以灰度表示。此外,医学成像经常产生多模态图像。然而,对这些图像的分析和解释大多是按顺序进行的,或者像在自动工具的情况下一样,它们只是作为独立的信息源连接在一起。在这两种情况下,颜色感知和颜色对比都没有被利用。色彩感知和色彩对比在人类视觉有效识别物体中起着至关重要的作用,原则上可以扩展到自动系统中。在本文中,我们展示了颜色编码,特别是使用颜色对手模型,如何成为基于颜色的初步分割的有效工具。对公共数据库中收集的大脑多模态磁共振成像(MRI)进行了测试,结果显示了颜色编码在医学成像分析中的重要性。
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引用次数: 2
Textural features for automatic detection and categorisation of pneumonia in chest X-ray images 胸部x线图像中肺炎自动检测和分类的纹理特征
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00011
César Antonio Ortiz Toro, Á. García-Pedrero, M. Lillo-Saavedra, C. Gonzalo-Martín
Pneumonia is an acute lung infection caused by a variety of organisms, such as viruses, bacteria, or fungi, that poses a serious risk to vulnerable populations. The first step in the diagnosis and treatment of pneumonia is a prompt and accurate diagnosis, especially in the context of an epidemic outbreak such as COVID-19, where pneumonia is an important symptom. To provide tools for this purpose, this article evaluates the potential of three textural image characterisation methods, fractal dimension, radiomics, and superpixel-based histon, as biomarkers both to distinguish between healthy individuals and patients affected by pneumonia and to differentiate between potential pneumonia causes. The results show the ability of the textural characterisation methods tested to discriminate between nonpathological images and images with pneumonia, and how some of the generated models show the potential to characterise the general textural patterns that define viral and bacterial pneumonia, and the specific features associated with a COVID-19 infection.
肺炎是一种由病毒、细菌或真菌等多种生物引起的急性肺部感染,对脆弱人群构成严重风险。肺炎诊治的第一步是及时准确诊断,特别是在COVID-19等疫情暴发的情况下,肺炎是一个重要症状。为了提供这方面的工具,本文评估了三种纹理图像表征方法的潜力,分形维数、放射组学和基于超像素的组蛋白,作为区分健康个体和肺炎患者以及区分潜在肺炎病因的生物标志物。结果表明,所测试的纹理表征方法能够区分非病理性图像和肺炎图像,以及一些生成的模型如何显示出表征定义病毒性和细菌性肺炎的一般纹理模式的潜力,以及与COVID-19感染相关的特定特征。
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引用次数: 1
Generic Concept for Integrating Voice Assistance Into Smart Therapeutic Interventions 将语音辅助整合到智能治疗干预中的通用概念
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00017
Jens Scheible, Fabian Hofmann, M. Reichert, R. Pryss, Marc Schickler
Therapeutic Interventions (TIs) play an important role in modern medical and psychological treatments, but their integration into the digital world still shows deficits, e.g., in the integration of the auditory interface. Initiatives to integrate this interface into existing Internet- and Mobile-Based Interventions (IMIs) are largely focused on a small group of Voice Assistants (VAs) and their specific capabilities. To mitigate these drawbacks, the presented concept seamlessly integrates arbitrary VAs into the treatment process of TIs. To this end, an architecture - including a discussion of relevant requirements - is presented that, on the one hand, uses VAs as the only point of contact with patients and, on the other hand, provides a comprehensive web-based backend for Healthcare Providers (HCPs). Based on the architecture, a proof-of-concept implementation using Amazon Alexa is presented. Finally, it is discussed that the scenario addressed and the solution presented have great potential, but still need a lot of work and technical considerations.
治疗干预(ti)在现代医学和心理治疗中发挥着重要作用,但它们与数字世界的整合仍然存在缺陷,例如听觉界面的整合。将该接口集成到现有的基于互联网和移动设备的干预措施(IMIs)中的举措主要集中在一小部分语音助理(VAs)及其特定功能上。为了减轻这些缺点,提出的概念无缝地将任意VAs集成到ti的治疗过程中。为此,本文提出了一种体系结构(包括对相关需求的讨论),该体系结构一方面使用VAs作为与患者的唯一接触点,另一方面为医疗保健提供者(hcp)提供全面的基于web的后端。在此基础上,提出了一个使用Amazon Alexa的概念验证实现。最后,讨论了所处理的场景和所提出的解决方案具有很大的潜力,但仍需要大量的工作和技术考虑。
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引用次数: 0
Optimum Thresholding for Medical Brain Images Based on Tsallis Entropy and Bayesian Estimation 基于Tsallis熵和贝叶斯估计的医学脑图像最佳阈值分割
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00071
Sijin Luo, Zhehao Luo, Zhi-Qin Zhan, Guoyuan Liang
Thresholding is a popular technique for image segmentation, specifically in the field of medical image processing. The main challenge for image thresholding is to determine the optimum threshold based on intensity distributions of object and background in the image. In this paper, we propose a new image thresholding method by injecting the Bayesian probability estimation into the classical Tsallis entropy framework. The classical algorithm assumes that the intensity distribution of object does not affect the background pixels, and vice versa. However, the intensity distributions of object and background are essentially crossed. It is possible to estimate the probability of a pixel belonging to object or background by Bayes rule, and use it to update the classical form of Tsallis entropy. The optimum threshold is finally determined by optimizing the information measure function defined with the new form of Tsallis entropy. Extensive experiments conducted over two public datasets of medical brain images have verified the significant superiority of the proposed method.
阈值分割是一种流行的图像分割技术,特别是在医学图像处理领域。图像阈值分割的主要挑战是根据图像中物体和背景的强度分布确定最佳阈值。本文提出了一种新的图像阈值分割方法,将贝叶斯概率估计注入到经典的Tsallis熵框架中。经典算法假设物体的强度分布不影响背景像素,反之亦然。然而,物体和背景的强度分布基本上是交叉的。利用贝叶斯规则可以估计出像素属于目标或背景的概率,并用它来更新经典形式的Tsallis熵。通过对新形式的Tsallis熵定义的信息度量函数进行优化,最终确定最优阈值。在两个公开的医学脑图像数据集上进行的大量实验验证了所提出方法的显著优越性。
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引用次数: 1
Attention-driven Spatial Transformer Network for Abnormality Detection in Chest X-Ray Images 用于胸部x线图像异常检测的注意力驱动空间变压器网络
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00051
Joana Rocha, Sofia Cardoso Pereira, J. Pedrosa, A. Campilho, A. Mendonça
Backed by more powerful computational resources and optimized training routines, deep learning models have attained unprecedented performance in extracting information from chest X-ray data. Preceding other tasks, an automated abnormality detection stage can be useful to prioritize certain exams and enable a more efficient clinical workflow. However, the presence of image artifacts such as lettering often generates a harmful bias in the classifier, leading to an increase of false positive results. Consequently, health care would benefit from a system that selects the thoracic region of interest prior to deciding whether an image is possibly pathologic. The current work tack-les this binary classification exercise using an attention-driven and spatially unsupervised Spatial Transformer Network (STN). The results indicate that the STN achieves similar results to using YOLO-cropped images, with fewer computational expenses and without the need for localization labels. More specifically, the system is able to distinguish between normal and abnormal CheXpert Images with a mean AUC of 84.22%.
在更强大的计算资源和优化的训练例程的支持下,深度学习模型在从胸部x射线数据中提取信息方面取得了前所未有的性能。在其他任务之前,自动异常检测阶段可以帮助确定某些检查的优先级,并实现更有效的临床工作流程。然而,图像伪影(如刻字)的存在往往会在分类器中产生有害的偏差,导致假阳性结果的增加。因此,医疗保健将受益于一个系统,选择感兴趣的胸部区域之前,决定是否可能是病理性的图像。目前的工作使用一个注意力驱动和空间无监督的空间变压器网络(STN)来解决这种二元分类练习。结果表明,STN获得了与使用yolo裁剪图像相似的结果,计算费用更少,不需要定位标签。更具体地说,该系统能够区分正常和异常CheXpert图像,平均AUC为84.22%。
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引用次数: 5
The Impact of General Data Protection Regulation on the Australasian Type-1 Diabetes Platform 一般数据保护条例对澳大利亚1型糖尿病平台的影响
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00043
Zhe Wang, A. Stell, R. Sinnott, Addn Study Group
Australia is a region with a high incidence of diabetes with approximately 1.2 million Australians diagnosed with this condition. In 2012, the Juvenile Diabetes Research Foundation (JDRF - www.jdrf.org.au) provided funding to establish the national registry - the Australasian Diabetes Data Network (ADDN - www.addn.org.au) populated with extensive longitudinal data on patients with Type-1 Diabetes (T1D). The ADDN registry has evolved over time and now includes data on over 20,000 patients from 22 paediatric centres and 11 adult centres across Australasia, i.e., where the data is uploaded from hospitals and not manually entered. This data has historically been de-identified at source, however moving forward there is increased demand from the clinical research community to link between data-sets using fully identifying data. In this context, this paper explores the challenges this poses with regards to the evolving processes that must be incorporated for data collection and use, e.g. e-Consent, and especially the impact of General Data Protection Regulation (GDPR) on the ADDN processes.
澳大利亚是一个糖尿病高发地区,大约有120万澳大利亚人被诊断患有糖尿病。2012年,青少年糖尿病研究基金会(JDRF - www.jdrf.org.au)提供资金,建立了一个国家登记处——澳大利亚糖尿病数据网络(ADDN - www.addn.org.au),其中包含大量1型糖尿病(T1D)患者的纵向数据。随着时间的推移,ADDN登记处不断发展,现在包括来自澳大利亚22个儿科中心和11个成人中心的20 000多名患者的数据,即数据是从医院上传的,而不是手动输入的。从历史上看,这些数据在源头上是去识别的,然而,临床研究界对使用完全识别数据将数据集联系起来的需求越来越大。在此背景下,本文探讨了数据收集和使用必须纳入的不断发展的过程所带来的挑战,例如电子同意,特别是一般数据保护条例(GDPR)对ADDN过程的影响。
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引用次数: 1
Left and Right Ventricular Segmentation Based on 3D Region-Aware U-Net 基于三维区域感知U-Net的左右心室分割
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00031
Xiao-jing Huang, Wenjie Chen, Xueting Liu, Huisi Wu, Zhenkun Wen, Linlin Shen
The cardiac is one of the essential organs, and the segmentation of the left and right ventricular of cardiac is essential in diagnosing various heart diseases. The most popular method for the segmentation of 3D MRI images is the nnUNet. However, the 3D MRI volume of the ventricular contains other organs which interfere with the segmentation of the ventricular. Hence, we proposed a novel region-aware U-Net segmentation method RegUNet for ventricular segmentation. RegUNet improves the ventricular's segmentation performance by first capturing the region of interest (RoI) of the ventricular and then segmenting the ventricular with the captured RoI features, which reduces the segmentation module's difficulty by keeping the cardiac's features and leaving others such that RegUNet can focus on ventricular segmentation. Besides, since the model segments the ventricular with the captured RoI features, it saves the model's computing resources from identifying the background of the volume. Since 3D cardiac MRI volumes scanned by the different devices have diverse statistical characteristics, which causes the model's performance in processing the multi-source cardiac volumes to be unstable. We stabilize the model's performance with a multi-sources feature normalization strategy, which normalizes the feature from a different source with different parameters. We validated the proposed method on the M&MS dataset, a multi-sources 3D MRI cardiac segmentation dataset. Experiments showed that RegUNet's segmentation ability reached the state-of-the-art.
心脏是人体的重要器官之一,左、右心室的分割在各种心脏疾病的诊断中是必不可少的。目前最流行的3D MRI图像分割方法是nnUNet。然而,心室的三维MRI体积包含其他器官,这些器官会干扰心室的分割。为此,我们提出了一种新的区域感知U-Net分割方法RegUNet进行心室分割。RegUNet首先捕获心室的感兴趣区域(RoI),然后利用捕获的感兴趣区域特征对心室进行分割,从而提高了心室分割的性能,这降低了分割模块的难度,保留了心脏的特征,留下了其他特征,使RegUNet可以专注于心室分割。此外,由于模型使用捕获的RoI特征对心室进行分割,因此节省了模型识别体积背景的计算资源。由于不同设备扫描的三维心脏MRI体积具有不同的统计特征,导致模型处理多源心脏体积的性能不稳定。我们使用多源特征归一化策略来稳定模型的性能,该策略对来自不同参数的不同源的特征进行归一化。我们在多源三维MRI心脏分割数据集M&MS数据集上验证了所提出的方法。实验表明,RegUNet的分割能力达到了最先进的水平。
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引用次数: 1
The value of compression for taxonomic identification 压缩在分类学鉴定中的价值
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00055
Jorge Miguel Silva, João Rafael Almeida
Advances in DNA sequencing technologies have led to an unprecedented growth of sequenced data. However, when sequencing de-novo genomes, one of the biggest challenges is the classification of DNA sequences that do not match with any biological sequence from the literature. The use of reference-free methods to identify these organisms supported by compressors is one strategy for taxonomic identification. However, with the high number of compressors available, and the computational resources required to operate them, there is a problem in selecting the best compressors for classification with limited computational resources. In this paper, we present a two-step pipeline to analyze nine compressors, to understand which ones could be the best candidates for taxonomic identification. We use 500 randomly selected sequences from five taxonomic groups to conduct this analysis. The results show that besides being an excellent repre-sentative feature, depending on the compressor, the Normalized Compression (NC) reflects different aspects concerning the nature of a given sequence and its complexity. Furthermore, we show that neither the compression capability of a compressor nor the compressibility of the file correlates with classification accuracy. The code used in this work is publicly available at https://github.com/bioinformatics-ua/COMPACT.
DNA测序技术的进步导致了测序数据的空前增长。然而,当测序de-novo基因组时,最大的挑战之一是DNA序列的分类与文献中任何生物序列不匹配。使用无参考文献的方法来鉴定这些由压缩机支持的生物是分类鉴定的一种策略。然而,由于可用的压缩机数量众多,以及运行它们所需的计算资源,在计算资源有限的情况下选择最佳压缩机进行分类存在问题。在本文中,我们提出了一个两步管道来分析9个压缩机,以了解哪些压缩机可能是分类鉴定的最佳候选者。我们从5个分类类群中随机选择500个序列进行分析。结果表明,除了是一个很好的代表性特征外,根据压缩器的不同,归一化压缩(NC)反映了给定序列的性质及其复杂性的不同方面。此外,我们表明压缩器的压缩能力和文件的可压缩性都与分类精度无关。本工作中使用的代码可在https://github.com/bioinformatics-ua/COMPACT上公开获得。
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引用次数: 3
Visualising Time-evolving Semantic Biomedical Data 可视化时间演化的语义生物医学数据
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00053
Arnaldo Pereira, João Rafael Almeida, Rui Pedro Lopes, J. L. Oliveira
Today, medical studies enable a deeper understanding of health conditions, diseases and treatments, helping to improve medical care services. In observational studies, an adequate selection of datasets is important, to ensure the study's success and the quality of the results obtained. During the feasibility study phase, inclusion and exclusion criteria are defined, together with specific database characteristics to construct the cohort. However, it is not easy to compare database characteristics and their evolution over time during this selection. Data comparisons can be made using the data properties and aggregations, but the inclusion of temporal information becomes more complex due to the continuous evolution of concepts over time. In this paper, we propose two visualisation methods aiming for a better description of data evolution in clinical registers using biomedical standard vocabularies.
今天,医学研究使人们能够更深入地了解健康状况、疾病和治疗方法,有助于改善医疗保健服务。在观察性研究中,充分选择数据集是重要的,以确保研究的成功和所获得结果的质量。在可行性研究阶段,定义纳入和排除标准,以及特定的数据库特征来构建队列。但是,在此选择过程中比较数据库特征及其随时间的演变并不容易。可以使用数据属性和聚合进行数据比较,但是由于概念随着时间的推移而不断演变,因此包含时间信息变得更加复杂。在本文中,我们提出了两种可视化方法,旨在使用生物医学标准词汇更好地描述临床登记册中的数据演变。
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引用次数: 1
Magnitude-image based data-consistent deep learning method for MRI super resolution 基于震级图像的MRI超分辨率数据一致性深度学习方法
Pub Date : 2022-07-01 DOI: 10.1109/CBMS55023.2022.00060
Ziyan Lin, Zihao Chen
Magnetic Resonance Imaging (MRI) is important in clinic to produce high resolution images for diagnosis, but its acquisition time is long for high resolution images. Deep learning based MRI super resolution methods can reduce scan time without complicated sequence programming, but may create additional artifacts due to the discrepancy between training data and testing data. Data consistency layer can improve the deep learning results but needs raw k-space data. In this work, we propose a magnitude-image based data consistency deep learning MRI super resolution method to improve super resolution images' quality without raw k-space data. Our experiments show that the proposed method can improve NRMSE and SSIM of super resolution images compared to the same Convolutional Neural Network (CNN) block without data consistency module.
磁共振成像(MRI)对临床诊断产生高分辨率图像具有重要意义,但高分辨率图像的采集时间较长。基于深度学习的MRI超分辨率方法可以减少扫描时间,无需复杂的序列编程,但由于训练数据和测试数据之间的差异,可能会产生额外的伪影。数据一致性层可以改善深度学习结果,但需要原始k空间数据。在这项工作中,我们提出了一种基于大小图像的数据一致性深度学习MRI超分辨率方法,以提高超分辨率图像的质量,而不需要原始k空间数据。实验表明,与不使用数据一致性模块的相同卷积神经网络(CNN)块相比,该方法可以提高超分辨率图像的NRMSE和SSIM。
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引用次数: 1
期刊
2022 IEEE 35th International Symposium on Computer-Based Medical Systems (CBMS)
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