Pub Date : 2021-01-01DOI: 10.36303/sagp.2021.2.3.0078
J. Ker, K. Outhoff
{"title":"The treatment of stable angina","authors":"J. Ker, K. Outhoff","doi":"10.36303/sagp.2021.2.3.0078","DOIUrl":"https://doi.org/10.36303/sagp.2021.2.3.0078","url":null,"abstract":"","PeriodicalId":21867,"journal":{"name":"South African General Practitioner","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88585640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36303/sagp.2021.2.5.0086
S. Schmidt
Osteoarthritis is also known as 'wear and tear' arthritis and is the most common form of arthritis. In people with osteoarthritis, the cartilage in the joints becomes worn down. Cartilage covers the ends of the bones and allows for the bones to move smoothly against each other (cartilage is the protective cushion on the end of the bones). Damage to the cartilage typically results in pain and leads to stiffness of the joint. In some cases, reduced joint movement and function may affect a person’s ability to perform daily tasks such as climbing stairs, walking or opening jars. Any joint may be affected; however, the joints in the knees, hips, fingers, feet and spine are most commonly affected by arthritis.
{"title":"Focus on ArthroGuard\u0000 ®\u0000 acute intensive joint protection & support","authors":"S. Schmidt","doi":"10.36303/sagp.2021.2.5.0086","DOIUrl":"https://doi.org/10.36303/sagp.2021.2.5.0086","url":null,"abstract":"Osteoarthritis is also known as 'wear and tear' arthritis and is the most common form of arthritis. In people with osteoarthritis, the cartilage in the joints becomes worn down. Cartilage covers the ends of the bones and allows for the bones to move smoothly against each other (cartilage is the protective cushion on the end of the bones). Damage to the cartilage typically results in pain and leads to stiffness of the joint. In some cases, reduced joint movement and function may affect a person’s ability to perform daily tasks such as climbing stairs, walking or opening jars. Any joint may be affected; however, the joints in the knees, hips, fingers, feet and spine are most commonly affected by arthritis.","PeriodicalId":21867,"journal":{"name":"South African General Practitioner","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79522194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36303/sagp.2021.2.5.0097
H. Parkar, Ss Mlambo, F. Bruwer, A. Cromarty
{"title":"Wounds: an overlooked burden (Part 4) – Burn wounds: a searing situation","authors":"H. Parkar, Ss Mlambo, F. Bruwer, A. Cromarty","doi":"10.36303/sagp.2021.2.5.0097","DOIUrl":"https://doi.org/10.36303/sagp.2021.2.5.0097","url":null,"abstract":"","PeriodicalId":21867,"journal":{"name":"South African General Practitioner","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77074793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36303/sagp.2021.2.6.0108
W. van Hougenhouck-Tulleken
In patients with chronic kidney disease, normochromic normocytic anaemia mainly develops from decreased renal synthesis of erythropoietin. The anaemia becomes more severe as the glomerular filtration rate (GFR) progressively decreases. No reticulocyte response occurs, red blood cell survival is decreased and there is an associated increased bleeding tendency due to uraemia-induced platelet dysfunction.
{"title":"Anaemia in chronic kidney disease","authors":"W. van Hougenhouck-Tulleken","doi":"10.36303/sagp.2021.2.6.0108","DOIUrl":"https://doi.org/10.36303/sagp.2021.2.6.0108","url":null,"abstract":"In patients with chronic kidney disease, normochromic normocytic anaemia mainly develops from decreased renal synthesis of erythropoietin. The anaemia becomes more severe as the glomerular filtration rate (GFR) progressively decreases. No reticulocyte response occurs, red blood cell survival is decreased and there is an associated increased bleeding tendency due to uraemia-induced platelet dysfunction.","PeriodicalId":21867,"journal":{"name":"South African General Practitioner","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88758205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36303/sagp.2021.2.3.0074
Sanjivani Pathak, S. Patil
Cancer is the most threatening disorder with increasing sufferers globally. The statistics of International Agency for Research on Cancer (IARC) indicate the arousal of 18.1 million new cancer cases causing 9.6 million deaths worldwide in the year 2018. Human body possesses a set of defensive processes carried out by the immune system whenever cancer is detected by its specialized cells. But when cancer escapes these processes, an anticancer therapy becomes the need. Three routes of treatment used widely today are Chemotherapy, Radiation therapy and Surgery. A new era in anticancer therapy is immunotherapy. It involves modification of patient’s own immune cells using biotechnology for treating cancer. There are various types of immunotherapies depending on the cells or cellular components modified and the molecules targeted in cancer cells. They include T cells, macrophages, specific receptors, proteins, chemical mediators and enzymes involved in immune response towards neoplasm. Hence immunotherapy is a much more specific and targeted therapy for cancer. A high therapeutic potential with minimum adverse effects and tumor specificity with no harm to normal body cells makes this therapy different than the pre existing ones. Immunotherapy will thus prove to be a major tool to combat all types
{"title":"Immunotherapy for cancer","authors":"Sanjivani Pathak, S. Patil","doi":"10.36303/sagp.2021.2.3.0074","DOIUrl":"https://doi.org/10.36303/sagp.2021.2.3.0074","url":null,"abstract":"Cancer is the most threatening disorder with increasing sufferers globally. The statistics of International Agency for Research on Cancer (IARC) indicate the arousal of 18.1 million new cancer cases causing 9.6 million deaths worldwide in the year 2018. Human body possesses a set of defensive processes carried out by the immune system whenever cancer is detected by its specialized cells. But when cancer escapes these processes, an anticancer therapy becomes the need. Three routes of treatment used widely today are Chemotherapy, Radiation therapy and Surgery. A new era in anticancer therapy is immunotherapy. It involves modification of patient’s own immune cells using biotechnology for treating cancer. There are various types of immunotherapies depending on the cells or cellular components modified and the molecules targeted in cancer cells. They include T cells, macrophages, specific receptors, proteins, chemical mediators and enzymes involved in immune response towards neoplasm. Hence immunotherapy is a much more specific and targeted therapy for cancer. A high therapeutic potential with minimum adverse effects and tumor specificity with no harm to normal body cells makes this therapy different than the pre existing ones. Immunotherapy will thus prove to be a major tool to combat all types","PeriodicalId":21867,"journal":{"name":"South African General Practitioner","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86938370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36303/sagp.2021.2.5.0093
J. Ker, K. Outhoff
{"title":"Aiming for improved blood pressure control","authors":"J. Ker, K. Outhoff","doi":"10.36303/sagp.2021.2.5.0093","DOIUrl":"https://doi.org/10.36303/sagp.2021.2.5.0093","url":null,"abstract":"","PeriodicalId":21867,"journal":{"name":"South African General Practitioner","volume":"2 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91405428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36303/sagp.2021.2.3.0077
L. De Beer
{"title":"Six strategies to prevent cancellations and no-shows","authors":"L. De Beer","doi":"10.36303/sagp.2021.2.3.0077","DOIUrl":"https://doi.org/10.36303/sagp.2021.2.3.0077","url":null,"abstract":"","PeriodicalId":21867,"journal":{"name":"South African General Practitioner","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81991097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36303/sagp.2021.2.6.0101
W. Visser, DJ Koot, Lsdv Terblanche
Atopic dermatitis (AD), also known as atopic eczema, is the most common form of eczema and is seen by healthcare professionals (HCPs) almost daily. It is a chronic, systemic condition characterised by immune dysregulation (type 2 inflammation), epidermal barrier dysfunction, intense pruritis, recurrent eczematous lesions, and presents with a relapsing, remitting course.1,2 The pathophysiology of AD is multifactorial, involving a genetic hypersensitivity predisposition to environmental factors.1 Although not diagnostic, the disease is often associated with increased IgE levels and commonly occurs alongside other atopic conditions such as allergic rhinoconjunctivitis, asthma and/or food allergies.2 The morphology and location of AD is considered characteristic for different ages: in infants, lesions tellingly manifest on the cheeks while usually sparing the perioral, perinasal and nappy area. With increasing age, lesions may present on extensor surfaces and classically in flexural folds (commonly the cubital and popliteal fossae), but may readily include the hands, wrists and ankles, head and neck as well as the trunk and shoulders.1,3 That being said, the clinical features in adults are highly variable.
{"title":"Contemporary treatments for atopic dermatitis and the dawn of targeted biological therapies","authors":"W. Visser, DJ Koot, Lsdv Terblanche","doi":"10.36303/sagp.2021.2.6.0101","DOIUrl":"https://doi.org/10.36303/sagp.2021.2.6.0101","url":null,"abstract":"Atopic dermatitis (AD), also known as atopic eczema, is the most common form of eczema and is seen by healthcare professionals (HCPs) almost daily. It is a chronic, systemic condition characterised by immune dysregulation (type 2 inflammation), epidermal barrier dysfunction, intense pruritis, recurrent eczematous lesions, and presents with a relapsing, remitting course.1,2 The pathophysiology of AD is multifactorial, involving a genetic hypersensitivity predisposition to environmental factors.1 Although not diagnostic, the disease is often associated with increased IgE levels and commonly occurs alongside other atopic conditions such as allergic rhinoconjunctivitis, asthma and/or food allergies.2 The morphology and location of AD is considered characteristic for different ages: in infants, lesions tellingly manifest on the cheeks while usually sparing the perioral, perinasal and nappy area. With increasing age, lesions may present on extensor surfaces and classically in flexural folds (commonly the cubital and popliteal fossae), but may readily include the hands, wrists and ankles, head and neck as well as the trunk and shoulders.1,3 That being said, the clinical features in adults are highly variable.","PeriodicalId":21867,"journal":{"name":"South African General Practitioner","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78124407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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