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Huge laryngeal saccular cyst causing obstructive sleep apnea. 巨大的喉囊囊肿导致阻塞性睡眠呼吸暂停
IF 1.1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2023-02-12 eCollection Date: 2023-07-01 DOI: 10.1007/s41105-023-00452-6
Masaaki Higashino, Shogo Furukawa, Yuko Inaka, Ryo Kawata
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引用次数: 0
Metabolomic approach for obstructive sleep apnea in adults: a systematic review. 代谢组学方法治疗成人阻塞性睡眠呼吸暂停:一项系统综述
IF 1.1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2023-02-08 eCollection Date: 2023-07-01 DOI: 10.1007/s41105-023-00445-5
Cristina Salles, Maria Clara Freitas, Amancio Souza, Paulo Ribeiro, Cristiane Dias, Michele Rosa, Miguel Meira E Cruz

Obstructive Sleep Apnea (OSA) corresponds to episodes of complete or partial upper airway obstruction during sleep. The gold standard for diagnosing OSA is polysomnography; however, metabolomics is an innovative and highly sensitive method that seeks to identify and quantify small molecules in biological systems. Identify the metabolites most frequently associated with obstructive sleep apnea in adults. The search for articles was conducted between October 2020 and August 2021, in electronic databases, such as MEDLINE/PubMed, Scielo, Embase, and Cochrane, through the combination of descriptors: obstructive sleep apnea, metabolomic, adult. This systematic review included all cross-sectional studies published, including human patients aged 18 years or older, of both genders who underwent type I or II polysomnography and metabolomics study. The search strategy selected 3697 surveys, and 4 of them were selected to be a part of this systematic review. Based on the analyzed surveys, it was found that all of them were able to diagnose OSA, reaching a sensitivity of 75-97%, and specificity that ranged from 72 to 100%; besides differentiating patients with OSA (severe, moderate, and mild) from simple snorers with a mean sensitivity of 77.2% and specificity of 66.25%. These findings suggest that, in addition to being used as a screening and diagnostic strategy for OSA, metabolomics has the potential to be used for severity stratification and to monitor the disease's progression.

阻塞性睡眠呼吸暂停(OSA)是指睡眠时上气道完全或部分阻塞。诊断 OSA 的金标准是多导睡眠图;然而,代谢组学是一种创新的高灵敏度方法,旨在识别和量化生物系统中的小分子。确定最常与成人阻塞性睡眠呼吸暂停相关的代谢物。在 2020 年 10 月至 2021 年 8 月期间,在 MEDLINE/PubMed、Scielo、Embase 和 Cochrane 等电子数据库中通过组合描述符(阻塞性睡眠呼吸暂停、代谢组学、成人)检索文章。本系统综述包括所有已发表的横断面研究,包括年龄在 18 岁或以上、接受过 I 型或 II 型多导睡眠图和代谢组学研究的男女患者。搜索策略选择了 3697 项调查,其中 4 项被选入本系统综述。根据所分析的调查发现,所有这些调查都能诊断出 OSA,灵敏度达到 75-97%,特异性在 72-100% 之间;此外,还能将 OSA 患者(重度、中度和轻度)与单纯打鼾者区分开来,平均灵敏度为 77.2%,特异性为 66.25%。这些研究结果表明,代谢组学除了可用作 OSA 的筛查和诊断策略外,还具有用于严重程度分层和监测疾病进展的潜力。
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引用次数: 0
The eveningness chronotype is associated with nightmare distress and dream recall: a cross-sectional study. 黄昏时间型与噩梦痛苦和梦境回忆有关:一项横断面研究
IF 1.1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2023-02-05 eCollection Date: 2023-07-01 DOI: 10.1007/s41105-023-00449-1
Yi-Seul Choo, Sang Wook Hong, Ga Eun Koo, Su-Hyun Han

Dreaming may be affected by sleep behavior; however, evidence of the effect of chronotypes on dreaming is limited. We investigated sleep patterns, dream recall, and nightmare distress according to chronotypes. This cross-sectional study retrospectively enrolled adult participants (age > 18 years) who visited a sleep laboratory between 2016 and 2021 and underwent standard polysomnography (PSG) and completed a self-reported questionnaire. Patients with major sleep disorders were excluded. Chronotypes and dreaming components were assessed using the Korean version of the morningness-eveningness questionnaire and a nine-item dreaming questionnaire (nightmare distress and dream recall), respectively. Among healthy participants without major sleep disorders, the eveningness chronotype correlated with better dream recall than the morningness and intermediate chronotypes. Participants with the eveningness chronotype were younger and more likely to be unmarried than those with the other chronotypes. No significant chronotype-based difference was observed in the subjective measurements of sleep quality, insomnia, daytime sleepiness, depression, and anxiety or in respiration and movement events on PSG. In multivariate linear regression analysis, the chronotypes were independently related to nightmare distress (b = - 0.296; p = 0.002) and dream recall (b = - 0.334; p = 0.002). The apnea-hypopnea index was associated with nightmare distress (b = - 0.209; p = 0.029) and dream recall (b = - 0.189; p = 0.044). Depression was positively correlated with nightmare distress (b = 0.450; p = 0.002). Dream recall was best in the eveningness group among healthy adults. Greater eveningness was associated with higher nightmare distress and better dream recall. Further research is needed to understand the role of chronotypes in dreaming.

做梦可能会受到睡眠行为的影响;然而,有关时型对做梦影响的证据却很有限。我们根据时间类型调查了睡眠模式、梦境回忆和噩梦困扰。这项横断面研究回顾性地招募了2016年至2021年期间前往睡眠实验室接受标准多导睡眠图(PSG)检查并填写自我报告问卷的成年参与者(年龄大于18岁)。患有严重睡眠障碍的患者被排除在外。研究人员分别使用韩国版晨昏程度问卷和九项梦境问卷(噩梦困扰和梦境回忆)评估了时型和梦境成分。在没有严重睡眠障碍的健康参与者中,黄昏时序型比晨昏时序型和中间时序型能更好地回忆梦境。与其他时间型的参与者相比,黄昏时间型的参与者更年轻,更有可能未婚。在睡眠质量、失眠、白天嗜睡、抑郁和焦虑的主观测量中,或在 PSG 的呼吸和运动事件中,均未观察到明显的时间型差异。在多变量线性回归分析中,时间型与噩梦困扰(b = - 0.296; p = 0.002)和梦境回忆(b = - 0.334; p = 0.002)独立相关。呼吸暂停-低通气指数与噩梦痛苦(b = - 0.209; p = 0.029)和梦境回忆(b = - 0.189; p = 0.044)相关。抑郁与噩梦痛苦呈正相关(b = 0.450;p = 0.002)。在健康成年人中,晚睡组的梦境回忆能力最强。晚睡程度越高,噩梦困扰越大,梦境回忆能力越强。要了解时型在做梦中的作用,还需要进一步的研究。
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引用次数: 0
The effect of cognitive-behavioral counseling with or without Citrus aurantium essential oil on sleep quality in pregnant women: a randomized controlled trial. 添加或不添加枳实精油的认知行为咨询对孕妇睡眠质量的影响:随机对照试验。
IF 1.1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2023-02-05 eCollection Date: 2023-07-01 DOI: 10.1007/s41105-023-00451-7
Narges Rahmani, Mostafa Araj-Khodaei, Sakineh Mohammad-Alizadeh-Charandabi, Khalil Esmaeilpour, Maryam Montazeri, Mojgan Mirghafourvand

Sleep disorder is very common during pregnancy. Non-pharmacological treatments are a priority to improve the sleep pattern. This study aimed to determine the effect of cognitive-behavioral counseling with or without Citrus aurantium essential oil on sleep quality (primary outcome) and anxiety and quality of life (secondary outcomes). This randomized controlled trial was performed on 75 pregnant women in Tabriz, Iran. Participants were randomly assigned to the intervention and control groups. The first intervention group received 8 sessions of cognitive-behavioral counseling and aromatherapy with Citrus aurantium essential oil 15-20 min before bedtime. The second intervention group received cognitive-behavioral counseling and aromatherapy with placebo and the control group received only routine prenatal care. Pittsburgh Sleep Quality Index, Pregnancy-Specific Quality of life Questionnaire, and Pregnancy-Specific Anxiety Scale were completed before and after intervention. After the intervention based on ANCOVA test and by adjusting the baseline score, the mean score of anxiety in the intervention group 1 (AMD: - 4.54; 95% CI - 6.79 to - 2.28) and intervention group 2 (AMD: - 3.30; 95% CI - 5.60 to - 0.97) was significantly lower than the control group. Also, the mean score of quality of life in intervention group 1 (AMD: 2.55; 95% CI 0.45-4.65) and intervention group 2 (AMD: 2.72; 95% CI 0.60-4.83) was significantly higher than the control group, but there was no statistically significant difference between the study groups in terms of sleep quality (P > 0.05). Also, there was no statistically significant difference between the two intervention groups after the intervention in terms of anxiety (P = 0.379) and quality of life (P = 0.996). Cognitive-behavioral counseling reduced anxiety and improved quality of life. However, further trials are required to reach a definitive conclusion. Iranian Registry of Clinical Trials (IRCT): IRCT20120718010324N63. Date of registration: 4/10/2020. URL: https://en.irct.ir/user/trial/54986/view; Date of first registration: 18/10/2020.

睡眠障碍在孕期非常常见。非药物治疗是改善睡眠模式的当务之急。本研究旨在确定认知行为咨询加或不加枳实精油对睡眠质量(主要结果)以及焦虑和生活质量(次要结果)的影响。这项随机对照试验针对伊朗大不里士的 75 名孕妇进行。参与者被随机分配到干预组和对照组。第一干预组接受 8 次认知行为咨询,并在睡前 15-20 分钟使用枳实精油进行芳香疗法。第二干预组接受认知行为咨询和香薰治疗,并使用安慰剂,对照组只接受常规产前护理。干预前后分别完成了匹兹堡睡眠质量指数、孕期生活质量问卷和孕期焦虑量表。干预后,根据方差分析检验并调整基线得分,干预组 1(AMD:- 4.54;95% CI - 6.79 至 - 2.28)和干预组 2(AMD:- 3.30;95% CI - 5.60 至 - 0.97)的焦虑平均得分明显低于对照组。此外,干预组 1(AMD:2.55;95% CI 0.45-4.65)和干预组 2(AMD:2.72;95% CI 0.60-4.83)的生活质量平均得分明显高于对照组,但在睡眠质量方面,研究组之间没有统计学差异(P > 0.05)。此外,干预后,两组干预者在焦虑(P = 0.379)和生活质量(P = 0.996)方面的差异也无统计学意义。认知行为咨询可减轻焦虑,提高生活质量。不过,要得出明确的结论,还需要进一步的试验。伊朗临床试验登记处(IRCT):IRCT20120718010324N63.注册日期:4/10/2020.URL: https://en.irct.ir/user/trial/54986/view; 首次注册日期:18/10/2020.
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引用次数: 0
Correlation of serum prolactin with sleep duration, wake-up hour, and phases of the menstrual cycle in healthy adult subjects. 血清催乳素与健康成人睡眠时间、起床时间和月经周期的相关性
IF 1.1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2023-01-31 eCollection Date: 2023-07-01 DOI: 10.1007/s41105-023-00448-2
Darya Saeed Abdulateef

Prolactin is affected by several factors: sex, age, BMI, sleep duration, menopausal status, and menstrual cycle phases. However, previous studies on this topic have caused some confusion, and the duration from the wake-up hour to sample collection has not been correlated with prolactin levels. This study aims to assess the correlation of prolactin levels with sleep duration, the durations from waking to sample collection and some demographic factors. To compare serum prolactin levels between males, reproductive females, and menopausal females and between menstrual cycle phases. In a study of 192 healthy adult subjects. Prolactin was compared between males, reproductive females, and menopausal females and different ages, BMI groups, and different menstrual cycle phases. The correlation between prolactin levels with the duration from waking to sample collection, sleep duration, age, BMI, and waist circumference were assessed. The highest median prolactin was among reproductive females, and menopausal females showed the lowest prolactin level compared to reproductive females and males. Prolactin levels were not significantly different between phases of the menstrual cycle. The only significant predictor of prolactin levels in males and females was the duration between the wake-up hour and sample collection. The duration from the wake-up hour to sample collection significantly predicts prolactin levels in healthy subjects. Prolactin levels are highest in reproductive females and lowest during menopause, while no significant differences were found between menstrual cycle phases. Sleep duration and other demographic factors are not significantly correlated with prolactin levels in healthy subjects with normal prolactin levels.

催乳素受多种因素影响:性别、年龄、体重指数、睡眠时间、绝经状态和月经周期阶段。然而,以往有关这一主题的研究却引起了一些混淆,从起床到样本采集的持续时间与催乳素水平并不相关。本研究旨在评估催乳素水平与睡眠时间、从醒来到样本采集的持续时间以及一些人口统计学因素之间的相关性。比较男性、生育期女性、绝经期女性以及不同月经周期阶段的血清催乳素水平。在一项针对 192 名健康成年受试者的研究中。对男性、生育期女性、绝经期女性以及不同年龄、体重指数组和不同月经周期阶段的催乳素进行了比较。研究还评估了泌乳素水平与从醒来到采集样本的持续时间、睡眠持续时间、年龄、体重指数和腰围之间的相关性。与生育期女性和男性相比,更年期女性的催乳素水平最低。催乳素水平在月经周期的不同阶段没有显著差异。男性和女性催乳素水平的唯一重要预测指标是起床时间与样本采集之间的持续时间。从起床到样本采集的持续时间可显著预测健康受试者的催乳素水平。生育期女性的催乳素水平最高,更年期女性的催乳素水平最低,而不同月经周期阶段的催乳素水平没有明显差异。在催乳素水平正常的健康受试者中,睡眠持续时间和其他人口统计学因素与催乳素水平无明显相关性。
{"title":"Correlation of serum prolactin with sleep duration, wake-up hour, and phases of the menstrual cycle in healthy adult subjects.","authors":"Darya Saeed Abdulateef","doi":"10.1007/s41105-023-00448-2","DOIUrl":"10.1007/s41105-023-00448-2","url":null,"abstract":"<p><p>Prolactin is affected by several factors: sex, age, BMI, sleep duration, menopausal status, and menstrual cycle phases. However, previous studies on this topic have caused some confusion, and the duration from the wake-up hour to sample collection has not been correlated with prolactin levels. This study aims to assess the correlation of prolactin levels with sleep duration, the durations from waking to sample collection and some demographic factors. To compare serum prolactin levels between males, reproductive females, and menopausal females and between menstrual cycle phases. In a study of 192 healthy adult subjects. Prolactin was compared between males, reproductive females, and menopausal females and different ages, BMI groups, and different menstrual cycle phases. The correlation between prolactin levels with the duration from waking to sample collection, sleep duration, age, BMI, and waist circumference were assessed. The highest median prolactin was among reproductive females, and menopausal females showed the lowest prolactin level compared to reproductive females and males. Prolactin levels were not significantly different between phases of the menstrual cycle. The only significant predictor of prolactin levels in males and females was the duration between the wake-up hour and sample collection. The duration from the wake-up hour to sample collection significantly predicts prolactin levels in healthy subjects. Prolactin levels are highest in reproductive females and lowest during menopause, while no significant differences were found between menstrual cycle phases. Sleep duration and other demographic factors are not significantly correlated with prolactin levels in healthy subjects with normal prolactin levels.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"21 1","pages":"319-327"},"PeriodicalIF":1.1,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10900018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47682273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of the COVID-19 pandemic on diagnosis of sleep apnea: an observational study of a hybrid virtual care clinical pathway. COVID-19大流行对睡眠呼吸暂停诊断的影响:混合虚拟护理临床路径的观察研究。
IF 1.1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2023-01-21 eCollection Date: 2023-07-01 DOI: 10.1007/s41105-023-00447-3
Kimihiko Murase, Owen D Lyons

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there has been a reduction in patient uptake of in-person care, likely in part, due to patients' fear of contracting COVID infection. We aimed to examine changes in the proportion of patients assessed in a sleep clinic who subsequently underwent in-lab polysomnography before and during the pandemic. A retrospective study was conducted, comparing the periods September 2018-April 2019 (pre-pandemic) and September 2020-April 2021 (pandemic). Among the patients who were referred to an ambulatory sleep clinic in Toronto, Ontario for assessment of possible sleep apnea, the number of patients who underwent diagnostic PSG within 90 days from the first consultation with a physician was analyzed. Significantly lower number of patients underwent PSG in the pandemic than the pre-pandemic period [122/229 patients (53.3%) vs. 169/208 patients (81.3%), p < 0.001]. Older age and having a consultation in the months of full-blown pandemic, which was defined as month with its average of newly confirmed COVID-19 positive cases in Ontario > 1000 cases/day, were associated with declining PSG in the pandemic period. Among patients who underwent PSG, sleep apnea was found in 114/169 (67.5%) and 85/122 (69.7%) patients in the pre-pandemic and the pandemic period, respectively (p = 0.69). During the pandemic, there was a dramatic reduction in uptake of in-lab PSG. It is very likely that a significant proportion of patients in this cohort had sleep apnea that went undiagnosed with significant implications for health outcomes.

自 2019 年冠状病毒病(COVID-19)大流行以来,患者接受现场护理的人数有所减少,部分原因可能是患者害怕感染 COVID。我们旨在研究在大流行之前和期间,在睡眠诊所接受评估并随后接受实验室多导睡眠图检查的患者比例的变化。我们进行了一项回顾性研究,对 2018 年 9 月至 2019 年 4 月(大流行前)和 2020 年 9 月至 2021 年 4 月(大流行期间)进行了比较。在被转诊到安大略省多伦多市一家非住院睡眠诊所进行可能的睡眠呼吸暂停评估的患者中,分析了在首次就诊后 90 天内接受 PSG 诊断的患者人数。大流行期间接受 PSG 检查的患者人数明显少于大流行前[122/229 名患者(53.3%)对 169/208 名患者(81.3%),P 1000 例/天],这与大流行期间 PSG 检查人数减少有关。在接受 PSG 检查的患者中,大流行前和大流行期间分别有 114/169 人(67.5%)和 85/122 人(69.7%)发现了睡眠呼吸暂停(p = 0.69)。在大流行期间,实验室内 PSG 的使用率急剧下降。这组患者中很可能有很大一部分患有睡眠呼吸暂停,但未得到诊断,从而对健康状况产生了重大影响。
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引用次数: 0
Sleep and body composition, physical function in older women. 老年妇女的睡眠、身体成分和身体功能
IF 1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2023-01-16 eCollection Date: 2023-04-01 DOI: 10.1007/s41105-023-00443-7
Yoko Komada
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引用次数: 0
Prevalence and risk factors of poor subjective sleep quality in elite judo athletes. 优秀柔道运动员主观睡眠质量差的患病率及危险因素分析
IF 1.1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2023-01-13 eCollection Date: 2023-07-01 DOI: 10.1007/s41105-023-00444-6
Takafumi Monma, Takashi Matsui, Kosei Inoue, Katsuyuki Masuchi, Takashi Okada, Masahiro Tamura, Takanori Ishii, Makoto Satoh, Kumpei Tokuyama, Fumi Takeda

This study aimed to determine the prevalence and risk factors of poor subjective sleep quality in elite judo athletes. A subjective cross-sectional questionnaire survey was conducted with 106 elite judo athletes who participated in the training camp of the Japanese national team. Eighty-six respondents (men: 52.3%; average age: 22.9 ± 3.1 years) with complete responses were included in the analysis (valid response rate: 81.1%). Subjective sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). The prevalence of poor sleep quality (PSQI score ≥ 5.5), the mean PSQI score, and subscale scores were investigated. Relationships between poor sleep quality and attributes, lifestyle habits, competition-based activities, and psychological distress were explored using Fisher's exact tests and multivariate logistic regression analysis. Thirty-five respondents (40.7%) reported poor sleep quality. The percentage and subscale scores of the respondents for sleep latency, sleep duration, and daytime dysfunction were higher than those of the population of Japanese national-level athletes. The mean PSQI score of the respondents was similar to that of some elite athlete populations but higher than those of others. Multivariate logistic regression analysis revealed that psychological distress was associated with poor sleep quality. In conclusion, the prevalence of poor subjective sleep quality in elite judo athletes was suggested to be similar or higher among elite athlete population. Sleep latency, sleep duration, and daytime dysfunction status were worse in elite judo athletes than in Japanese national-level athletes. Psychological distress was a risk factor for poor subjective sleep quality in elite judo athletes.

Supplementary information: The online version contains supplementary material available at 10.1007/s41105-023-00444-6.

本研究旨在确定精英柔道运动员主观睡眠质量差的发生率和风险因素。研究对参加日本国家队训练营的 106 名柔道精英运动员进行了主观横断面问卷调查。其中 86 名受访者(男性:52.3%;平均年龄:22.9 ± 3.1 岁)回答完整,纳入分析(有效回答率:81.1%)。主观睡眠质量采用匹兹堡睡眠质量指数(PSQI)进行评估。对睡眠质量差(PSQI 评分≥ 5.5)的发生率、PSQI 平均分和分量表评分进行了调查。通过费雪精确检验和多变量逻辑回归分析,探讨了睡眠质量差与属性、生活习惯、竞赛活动和心理困扰之间的关系。35 名受访者(40.7%)表示睡眠质量差。受访者在睡眠潜伏期、睡眠时间和日间功能障碍方面的百分比和分量表得分均高于日本国家级运动员。受访者的 PSQI 平均得分与一些精英运动员群体相似,但高于其他群体。多变量逻辑回归分析表明,心理困扰与睡眠质量差有关。总之,主观睡眠质量差在柔道精英运动员中的发生率与其他精英运动员相似或更高。与日本国家级运动员相比,精英柔道运动员的睡眠潜伏期、睡眠时间和白天功能障碍状况更差。心理困扰是精英柔道运动员主观睡眠质量差的一个风险因素:在线版本包含补充材料,可在 10.1007/s41105-023-00444-6。
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引用次数: 0
Differences in psychosocial factors and sleep study findings between delayed sleep-wake phase disorder and hypersomnia in teenagers. 青少年延迟性睡眠-觉醒期障碍和嗜睡的心理社会因素和睡眠研究结果的差异
IF 1.1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2023-01-10 eCollection Date: 2023-04-01 DOI: 10.1007/s41105-022-00441-1
Yayumi Kamiyama, Yoshiyuki Kaneko, Kaori Saitoh, Ryuji Furihata, Michiko Konno, Makoto Uchiyama, Masahiro Suzuki

Central hypersomnia (HS) and delayed sleep-wake phase disorder (DSWPD) appear commonly in adolescents, and they severely reduce quality of life and have an enormous impact on academic performance and other aspects of development. Although these disorders are thought to be considerably different in etiology, it is sometimes difficult to distinguish them because of their similar clinical features. This study aimed to compare psychosocial factors and sleep study findings between HS and DSWPD in teenagers. The clinical data of 89 teenagers who visited the psychiatric section of the Sleep Medicine Center of Nihon University Itabashi Hospital from January 2013 to December 2019 were analyzed. Psychosocial factors were evaluated at the first visit, and polysomnography (PSG) and the multiple sleep latency test (MSLT) were performed for patients deemed to require definitive diagnosis. Compared with patients with HS, those with DSWPD had a higher rate of mother's employment, introversion, adjustment problems, events that triggered the disorder, concurrent mental disorders, habitual lateness, and difficulty attending school or work. PSG did not show any differences in sleep parameters between the two disorders, except for sleep latency. On the MSLT, sleep latency was shorter in those with HS on the second, third, and fourth tests. The present results suggest that focusing on psychosocial factors could be useful for differential diagnosis of the two disorders that appear commonly in adolescents.

中枢性嗜睡症(HS)和睡眠觉醒期延迟障碍(DSWPD)常见于青少年,它们严重降低了青少年的生活质量,并对学习成绩和其他方面的发展产生了巨大影响。虽然这两种疾病的病因被认为有很大不同,但由于其临床特征相似,有时很难将它们区分开来。本研究旨在比较青少年 HS 和 DSWPD 的心理社会因素和睡眠研究结果。研究分析了2013年1月至2019年12月期间到日本大学板桥医院睡眠医学中心精神科就诊的89名青少年的临床数据。首次就诊时对心理社会因素进行了评估,并对认为需要明确诊断的患者进行了多导睡眠图(PSG)和多重睡眠潜伏期测试(MSLT)。与 HS 患者相比,DSWPD 患者在母亲就业、性格内向、适应问题、引发障碍的事件、并发精神障碍、习惯性迟到、上学或工作困难等方面的比例更高。除睡眠潜伏期外,PSG 并未显示这两种疾病的睡眠参数有任何差异。在 MSLT 测试中,HS 患者在第二、第三和第四次测试中的睡眠潜伏期较短。本研究结果表明,关注心理社会因素有助于对这两种常见于青少年的疾病进行鉴别诊断。
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引用次数: 0
Association between the Pittsburgh sleep quality index and white matter integrity in healthy adults: a whole-brain magnetic resonance imaging study. 匹兹堡睡眠质量指数与健康成人白质完整性的关系:一项全脑磁共振成像研究
IF 1.1 4区 医学 Q4 CLINICAL NEUROLOGY Pub Date : 2023-01-02 eCollection Date: 2023-04-01 DOI: 10.1007/s41105-022-00442-0
Shinsuke Hidese, Miho Ota, Junko Matsuo, Ikki Ishida, Yuuki Yokota, Kotaro Hattori, Yukihito Yomogida, Hiroshi Kunugi

To disclose possible associations between poorer sleep quality and structural brain alterations in a non-psychiatric healthy population, this study investigated the association between the Pittsburgh sleep quality index (PSQI) and brain correlates, using a whole-brain approach. This study included 371 right-handed healthy adults (138 males, mean age: 46.4 ± 14.0 years [range: 18-75]) who were right-handed. Subjective sleep quality was assessed using the Japanese version of the PSQI (PSQI-J), and the cutoff score for poor subjective sleep quality was set at ≥ 6. Voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) were performed to examine whether a higher score of the PSQI-J indicates, poorer sleep quality is associated with gray matter volume and white matter microstructure alternations, respectively. Among the participants, 38.8% had a PSQI-J cutoff score of ≥ 6. VBM did not reveal any correlation between PSQI-J scores and gray matter volume. However, DTI revealed that PSQI-J global scores were significantly and negatively correlated with diffuse white matter fractional anisotropy (FA) values (p < 0.05, corrected). Moreover, the PSQI-J sleep disturbance and use of sleep medication component scores were significantly and negatively correlated with right anterior thalamic radiation and diffuse white matter FA values, respectively (p < 0.05, corrected). There were no significant differences in gray matter volume and white matter metrics (FA, axial, radial, and mean diffusivities) between the groups with PSQI-J scores above or below the cutoff. Our findings suggest that lower sleep quality, especially the use of sleep medication, is associated with impaired white matter integrity in healthy adults. Limitations of this study are relatively small number of participants and cross-sectional design. Fine sleep quality, possibly preventing the use of sleep medication, may contribute to preserve white matter integrity in the brain of healthy adults.

Supplementary information: The online version contains supplementary material available at 10.1007/s41105-022-00442-0.

为了揭示非精神病健康人群中睡眠质量较差与大脑结构改变之间可能存在的关联,本研究采用全脑方法调查了匹兹堡睡眠质量指数(PSQI)与大脑相关性之间的关联。这项研究包括 371 名右撇子健康成人(138 名男性,平均年龄:46.4 ± 14.0 岁 [范围:18-75])。主观睡眠质量采用日文版 PSQI(PSQI-J)进行评估,主观睡眠质量差的临界值定为≥6 分。研究人员还进行了基于体素的形态测量(VBM)和弥散张量成像(DTI),以检验 PSQI-J 分数越高,表明睡眠质量越差是否分别与灰质体积和白质微结构交替有关。在参与者中,38.8%的人的 PSQI-J 临界值得分≥ 6。VBM 没有发现 PSQI-J 评分与灰质体积之间有任何相关性。然而,DTI显示,PSQI-J总体评分与弥漫白质分数各向异性(FA)值呈显著负相关(p p p 补充信息:在线版本包含补充材料,可在 10.1007/s41105-022-00442-0获取。
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Sleep and Biological Rhythms
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