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One-Minute Finger Pulsation Measurement for Diabetes Rapid Screening with 1.3% to 13% False-Negative Prediction Rate 1分钟手指脉动测量用于糖尿病快速筛查,假阴性预测率为1.3% ~ 13%
Pub Date : 2021-02-23 DOI: 10.11648/J.BSI.20210601.12
Justin Chu, Wen-Tse Yang, Tung-Han Hsieh, Fu-Liang Yang
Previous non-invasive Diabetes Mellitus (DM) prediction methods for rapid screening suffered from the trade-off between speed and accuracy. The accurate results of questionnaires rely on long and detailed questions thus sacrifice speed, meanwhile, photoplethysmography (PPG) offers convenient and fast testing but lacking accuracy. In this work, we developed a 5-grade model to accurately screen out non-DM subjects (low prediction grades) via one-minute PPG measurement. This efficient and effective rapid screening will practically reduce the loading for further invasive verification on the remaining DM-grade subjects. A total of 2538 subjects are recruited (DM: 1310, non-DM: 1228) with two 1-minute PPG samples taken from each subject. The model includes 8 features: 3 autonomic- and 3 vascular-related PPG features, heart rate, and waist circumference. All 8 features monotonically alter with increased DM prediction grade. The model provides users 5 DM risk grades. While defined grade 1 and grade 2 as non-DM grades, the prediction result shows a low false-negative rate of 13%. If only considering grade 1 as non-DM, the false-negative rate will be significantly reduced to 1.3%. Thus subjects predicted as grades 1 and 2 are substantially away from DM. The remaining subjects with higher DM risk grades such as grades 3, 4, and 5 (or unlikely grade 2) are recommended to take clinical-standard invasive DM test for corresponding therapeutic treatment. A table for assessing the risk index for each feature is also compiled. We have experimentally demonstrated a 1-minute pulsation measurement with PPG-based device (SpO 2 oximeter, smartphone, or wearable device) can be an efficient/effective DM rapid screening technique to filter out non-DM subjects. The resulted high-risk feature indexes also pose as warning signs of the degradation of either autonomic or vascular functions for personal healthcare management. The fast and convenient execution and useful results suggest that our approach is very simple and informative for quick DM risk assessment.
以往用于快速筛查的非侵入性糖尿病(DM)预测方法在速度和准确性之间存在权衡。问卷调查的准确结果依赖于长而详细的问题,从而牺牲了速度,同时,光电体积脉搏图(PPG)提供了方便和快速的测试,但缺乏准确性。在这项工作中,我们开发了一个5级模型,通过一分钟PPG测量准确筛选非糖尿病受试者(低预测等级)。这种高效和有效的快速筛选实际上减少了对剩余dm级受试者进行进一步侵入性验证的工作量。共招募了2538名受试者(DM: 1310,非DM: 1228),并从每个受试者中抽取2个1分钟PPG样本。该模型包括8个特征:3个自主神经和3个血管相关的PPG特征、心率和腰围。8个特征均随DM预测等级的增加而单调变化。该模型为用户提供5个DM风险等级。将1级和2级定义为非dm级,预测结果显示假阴性率较低,为13%。如果仅将1级视为非dm,假阴性率将显著降低至1.3%。因此,预测为1级和2级的受试者基本上远离糖尿病。剩余的糖尿病风险等级较高的受试者,如3级、4级和5级(或不太可能为2级),建议进行临床标准的浸润性糖尿病检查,以进行相应的治疗。还编制了评估每个特征的风险指数的表格。我们通过实验证明,使用基于ppg的设备(SpO 2血氧计、智能手机或可穿戴设备)进行1分钟脉搏测量是一种高效/有效的糖尿病快速筛选技术,可以过滤掉非糖尿病受试者。由此产生的高风险特征指数也可作为自主神经或血管功能退化的警告信号,用于个人保健管理。快速方便的执行和有用的结果表明,我们的方法非常简单,信息丰富,可用于快速评估糖尿病风险。
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引用次数: 5
Estimation of Risk Factor’s Contribution to mortality from COVID-19 in Highly Populated European Countries 在人口稠密的欧洲国家,风险因素对COVID-19死亡率贡献的估计
Pub Date : 2021-01-22 DOI: 10.11648/J.BSI.20210601.11
U. Eliyahu, Avi Magid
Background: The outbreak of the COVID-19 epidemic and the excess of mortality attributed to COVID-19 worldwide raised the need to develop a simple and applicable mathematical model for predicting mortality in different countries, as well as to point out the risk factors for COVID-19 mortality, and, in particular, demographic risk factors. Methods: A linear model was developed based on demographic data (population density, percentage of population over age 65 and degree of urbanity) as well as a clinical data (number of days since the first case was diagnosed in each country) from 10 highly populated (over 8.5 million people) randomly selected European countries (Austria, Hungary, Portugal, Sweden, Czech Republic, Belgium, the Netherlands, Romania, Italy, France). A linear regression model was applied, using IBM SPSS version 20 software. Results: The proposed model predicts mortality among the selected countries. This model is found to be highly correlated (R2=0.821, p=0.042) with the actual (reported) number of deaths in each country. Percentage of population above age 65, population density and number of days since the first case appear at each state were found to be positively correlated with COVID-19 mortality, whereas urbanity were negatively correlated with mortality. Conclusions: Percentage of population above age 65 and population’s density and the number of days of exposure to COVID 19 are potential risk factors for dying from the pandemic, whereas, urbanity is considered a protective factor. However, it should be remembered that this model is based on data from medium to large populations and only in continental Europe. Moreover, it is based on mortality data of the "first wave" of the pandemic. Further study should evaluate the model accuracy based on data from the "second wave" and not only in continental Europe.
背景:2019冠状病毒病(COVID-19)疫情的爆发和全球范围内因COVID-19导致的死亡率过高,提出了开发一种简单适用的数学模型来预测不同国家死亡率的必要性,并指出COVID-19死亡率的危险因素,特别是人口危险因素。方法:根据随机选择的10个人口稠密的欧洲国家(奥地利、匈牙利、葡萄牙、瑞典、捷克、比利时、荷兰、罗马尼亚、意大利、法国)的人口统计数据(人口密度、65岁以上人口比例和城市化程度)和临床数据(每个国家确诊首例病例的天数)建立线性模型。采用IBM SPSS version 20软件建立线性回归模型。结果:提出的模型预测了所选国家的死亡率。研究发现,该模型与各国实际(报告)死亡人数高度相关(R2=0.821, p=0.042)。65岁以上人口比例、人口密度和各州出现首例病例的天数与COVID-19死亡率呈正相关,而城市化程度与死亡率呈负相关。结论:65岁以上人口比例、人口密度和暴露天数是导致死亡的潜在危险因素,城市化程度是保护因素。然而,应该记住,这个模型是基于来自中等到大量人口的数据,而且只在欧洲大陆。此外,它是根据大流行“第一波”的死亡率数据编制的。进一步的研究应该基于“第二次浪潮”的数据来评估模型的准确性,而不仅仅是在欧洲大陆。
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引用次数: 1
Mathematical Modeling and Optimal Control Analysis on Sedentary Behavior and Physical Activity in Relation to Cardiovascular Disease (CVD) 与心血管疾病相关的久坐行为和体力活动的数学建模及最优控制分析
Pub Date : 2020-12-31 DOI: 10.11648/J.BSI.20200504.13
L. Jibril, O. Odetunde
Cardiovascular diseases (CVDs) have remained the leading causes of global death in the last 16 years which is the cause of mortality of 17.7 million people every year. Nowadays, people live in a time where sitting takes up the majority of their daily affairs. The sedentary behavior for prolonged periods of time can leads to a problem of deadly disease such as heart disease, obesity, and diabetes. In this paper a deterministic model for the effects of prolonged sitting is designed. The model, which consists of three ordinary differentials equations is developed and analyzed to study the optimal control analysis on sedentary behavior, physical activity in relation to cardiovascular disease (CVD) in a community. The solutions of the model uniquely exist, nonnegative for all t ≥ 0 with nonnegative initial conditions in R3+, and bounded in a region ΩN. The basic reproduction number which measures the relationship threshold is presented. The model was extended and optimal control theory was applied to examine optimal strategies for controlling or eradicating the new cases of CVD that may be borne due to a life of inactivity. The control measures comprises of education or sensitization u1, living a healthy lifestyle (good nutrition, weight management) u2, and getting plenty of physical activity u3. The impact of using possible combinations of the three intervention strategies was investigated and analyzed. The results of the optimal control model using Pontryagin maximum principle (PMP) revealed that combination of education or sensitization with any other control strategy yields better result to reduce or eradicate the risk of new cases of CVD from sedentary lifestyle.
在过去16年中,心血管疾病仍然是全球死亡的主要原因,每年造成1 770万人死亡。如今,人们生活在一个坐着占据了大部分日常事务的时代。长时间久坐会导致心脏病、肥胖症和糖尿病等致命疾病。本文设计了长时间久坐影响的确定性模型。建立了由三个常微分方程组成的模型,并对其进行了分析,研究了社区中久坐行为、身体活动与心血管疾病(CVD)的最优控制分析。模型的解唯一存在,在R3+中对于所有t≥0且初始条件为非负的解均为非负,且解在一个区域ΩN内有界。给出了衡量关系阈值的基本再现数。对该模型进行了扩展,并应用最优控制理论来研究控制或根除由于生活不活动而可能产生的心血管疾病新病例的最优策略。控制措施包括教育或宣传u1,健康的生活方式(良好的营养,体重管理)u2,以及大量的体育活动u3。调查和分析了三种干预策略可能组合使用的影响。使用Pontryagin最大原理(PMP)的最优控制模型的结果显示,教育或敏化与任何其他控制策略相结合,可以降低或消除久坐生活方式引起的心血管疾病新病例的风险。
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引用次数: 0
Determinants of Dehydration Status and Associated Risk Factors of Cholera Outbreak in Oromia, Ethiopia 埃塞俄比亚奥罗米亚地区霍乱暴发的脱水状况决定因素及相关危险因素
Pub Date : 2020-03-10 DOI: 10.21203/rs.3.rs-16507/v1
Endale Alemayehu, T. Tilahun, Eshetu Mebrate
Introductions: Cholera is a diarrheal disease caused by infection of the intestine with the gram-negative bacteria Vibrio cholera. According to updated global burden of cholera estimate 2019 in Ethiopia 68,805,272 populations are at risk of cholera with incidence rate of 4 per 1000 population and case fatality of 3.8% estimated annual number of cases 275,221.Methods: The main objective of this study is to identify the significant risk factors of dehydration status of cholera outbreak in Oromia regional state of Ethiopia. Ordinal logistic regression was used to model the data by incorporating the assumption behind this novel model. Results: The results of the study indicated that of the total 965 cholera patients, most of them 560(58%) were severely dehydrated by cholera. The overall goodness of model (p-valu=0.07) shows that the model fits the data well. Besides, the proportional odds assumption also revealed that the slop coefficients in the model are the same across dehydration status (p-value=0.094). For those have history of travel, the odds of severely dehydrated versus the combined some dehydrated and no dehydrated was exp(1.133804)=3.11 times higher than those have no history of travel (p-value<0.01). All the other factors like history of contact with other patients, other sick patients in the family, Intravenous and Antibiotics drugs are statistically significant with 5% level of significance to determine the status of dehydration. Conclusions: The ordinal logistic regression was fitted the data well and most of the included factors were significant for the dehydration status of cholera outbreak.
霍乱是一种由革兰氏阴性菌霍乱弧菌感染肠道引起的腹泻疾病。根据最新的2019年全球霍乱负担估计,埃塞俄比亚有68,805,272人面临霍乱风险,发病率为每千人4人,病死率为3.8%,估计年病例数为275,221例。方法:本研究的主要目的是确定埃塞俄比亚奥罗米亚州地区霍乱暴发脱水状态的重要危险因素。序贯逻辑回归被用来对数据进行建模,并纳入了这个新模型背后的假设。结果:965例霍乱患者中,有560例(58%)为严重脱水。模型总体优度(p值=0.07)表明模型与数据拟合较好。此外,比例赔率假设还揭示了模型中的斜率系数在不同脱水状态下相同(p值=0.094)。有旅行史者发生严重脱水与部分脱水与未脱水相结合的几率是无旅行史者的exp(1.133804)=3.11倍(p值<0.01)。其他因素如与其他患者的接触史、家庭中其他患者、静脉注射和抗生素药物均有统计学意义,5%的显著性水平判断脱水状态。结论:有序logistic回归拟合效果良好,大部分因素对霍乱暴发脱水状况有显著影响。
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引用次数: 1
Service Availability and Readiness Assessment (SARA) of Health Facilities in Moyamba District Southern Province of Sierra Leone 塞拉利昂南部省莫扬巴区卫生设施服务提供情况和准备情况评估
Pub Date : 2019-12-27 DOI: 10.11648/J.BSI.20190404.12
B. Gegbe, B. Kandeh, Andrew Baimba
Sierra Leone needs strong information systems to adequately track progress made and to inform decisions about the implementation of health care programmes as it implements its recovery and resilience plans. A challenge observed with the national health management information system (HMIS) is the quality of routine reports from health facilities and districts. The objective of this research is to assess the service availability and readiness of health facilities in Moyamba district. This research was facility based cross sectional survey. A representative sample of 87 health facilities was selected for the assessment, with an oversampling of hospitals. In this sampling procedure 86% of the health facilities considered for this research were Government/Public owned facilities and 1.1% mission/faith owned facilities. Stat graphic 18 was used to do the data analysis. The district has 55% General Service Index (GSI) for all categories of health facilities. Readiness scores in preventive curative, antenatal care service and malaria services were above 90% in the district. The least readiness score was high level diagnostic equipment with 1%. Blood transmission services had the least specific readiness score of 4.3%. Government of Sierra Leone to Strengthening capacity of District Health Management Teams to plan, supervise and monitor all health facility programs at district levels.
塞拉利昂需要强大的信息系统来充分跟踪取得的进展,并在实施其恢复和复原力计划时为有关卫生保健规划实施的决策提供信息。国家卫生管理信息系统(HMIS)面临的一个挑战是卫生设施和地区例行报告的质量。这项研究的目的是评估莫扬巴地区卫生设施的服务提供情况和准备情况。本研究是基于设施的横断面调查。选取了87个卫生设施的代表性样本进行评估,并对医院进行了过抽样。在这一抽样程序中,本研究考虑的卫生设施中有86%是政府/公共拥有的设施,1.1%是教会/宗教拥有的设施。使用统计图18进行数据分析。该地区各类卫生设施的一般服务指数(GSI)为55%。该县预防治疗、产前保健服务和疟疾服务的准备程度得分在90%以上。准备度最低的是高级诊断设备,只有1%。血液输送服务的具体准备度得分最低,为4.3%。塞拉利昂政府:加强地区卫生管理小组在地区一级规划、监督和监测所有卫生设施方案的能力。
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引用次数: 41
Epidemiological Description of Dengue Fever Outbreak in Kebridhar District, Somali Region, Ethiopia – 2017 2017年埃塞俄比亚索马里地区克布里达尔区登革热疫情流行病学描述
Pub Date : 2019-12-23 DOI: 10.11648/J.BSI.20190404.11
Mikias Alayu, Fikirte Girma, Mengistu Biru, T. Teshome, Desalegn Belay
Dengue fever is caused by dengue virus (DENV), a member of the genus Flavivirus, family Flaviviridae. The virus is transmitted by the infected female mosquito called Aedes aegypti. There are four serotypes, DENV1 through DENV4. Dengue fever is one of the most important re-emerging arboviral disease, more than half of the world’s population are at risk of this disease. Starting from 2013 over 12,000 cases were reported from Ethiopia. Descriptive cross-sectional study design was applied to describe dengue fever outbreak data from Kebridhar District reported to Ethiopian Public Health Institute from May to June 2017. Ratios, proportions and rates were analyzed by using Microsoft excel and findings were presented by narrations, frequency distributions and graphs. A total of 101 dengue fever cases were reported from Kebridhar District of Somali Region. Sixty-eight-point three percent (69/101) were males and 9.9% (10/101) cases were hospitalized. The positivity rate of dengue virus was 76.9% (10/13). The median age of cases was 27 years (IQR: 22 – 38). The case fatality rate was zero and the attack rate was 86 cases per 100,000 population. Eighteen-point eight percent (19/101) cases had bleeding. All cases reported that, they had open water containers, no spraying of houses for six months prior to the onset of the fever and bed net utilization rate was 30.7%. Males and 50 – 54 years old individuals were highly affected groups. Ministry of Health Regional Health Bureau and District Health Office should work on vector and environmental control activities.
登革热是由登革热病毒(DENV)引起的,登革热病毒是黄病毒科黄病毒属的一员。这种病毒是由被感染的埃及伊蚊传播的。登革热有四种血清型,从登革热1型到登革热4型。登革热是最重要的再次出现的虫媒病毒性疾病之一,世界上一半以上的人口面临此病的风险。从2013年开始,埃塞俄比亚报告了1.2万多例病例。采用描述性横断面研究设计描述2017年5月至6月向埃塞俄比亚公共卫生研究所报告的kebrihar地区登革热暴发数据。运用Microsoft excel软件对比率、比例和比率进行分析,并以叙述、频率分布和图表的形式呈现结果。索马里地区克布里达尔区共报告了101例登革热病例。68.3%(69/101)为男性,9.9%(10/101)为住院病例。登革热病毒阳性率为76.9%(10/13)。病例中位年龄为27岁(IQR: 22 - 38)。病死率为零,发病率为每10万人86例。18.8%(19/101)的病例有出血。所有病例报告说,他们有开放的水容器,在发烧前6个月没有向房屋喷洒,蚊帐使用率为30.7%。男性和50 - 54岁的个体是高发人群。卫生部区域卫生局和区卫生局应开展病媒和环境控制活动。
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引用次数: 0
Statistical Analysis of Age Reporting Errors by Insured and Uninsured Patients in Cape Coast Teaching Hospital of Ghana 加纳海岸角教学医院参保与未参保患者年龄报告错误的统计分析
Pub Date : 2019-08-15 DOI: 10.11648/J.BSI.20190402.11
Eyiah-Bediako Francis, Bosson-Amedenu Senyefia, B. Sena
Age is a very important variable that guides clinicians to carryout diagnosis, treatment, as well as administering medical procedures to patients. Misreporting of age by patients to clinicians can have dire consequences on the patients’ health. This retrospective study used a 10 year demographic data involving the ages reported by 906,383 patients. Demographic indexes such as Whipples, Myers Blended and Joint Score were employed to analyse reported ages among insured and uninsured patients at the Cape Coast Teaching Hospital. The computed joint score values of 76.88 and 85.60 respectively for uninsured and insured patients qualified the data as highly inaccurate by the standards of interpretation of UN index. The summary of the digit preference of the uninsured and insured patients by Myers blended index approach were 29.34 and 29.87 respectively. The blended sum at the digits 0, 1, 2 and 5 exceeded 10% of the total blended population, an indication of over selection of ages ending in those digits by the insured and uninsured patients. Whipple’s index for uninsured and insured patients was 149.3 and 287.1 respectively. These values respectively show that the reliability of the ages reported were rough and very rough, by the Whipple’s index interpretation standards. The insured were found to have higher tendency of concentrating on ages ending in 0 and 5 than the uninsured. The study concluded that age data in Cape Coast Teaching Hospital is misreported and inaccurate and if not adjusted may result in wrong age-dependent medical procedures undertaken by clinicians. It was recommended among others for hospitals to institute innovative ways of recording ages such as using calendar of historical events technique where the patients could not recall their correct age.
年龄是一个非常重要的变量,它指导临床医生对患者进行诊断、治疗以及管理医疗程序。患者向临床医生谎报年龄可能会对患者的健康产生可怕的后果。这项回顾性研究使用了10年的人口统计数据,涉及906383名患者的年龄报告。采用Whipples、Myers blend和Joint Score等人口统计指标分析海岸角教学医院参保和未参保患者报告的年龄。未参保患者和参保患者的联合得分分别为76.88和85.60,按照UN指数的解释标准,该数据属于高度不准确。Myers混合指数法对未参保患者和参保患者数字偏好的综合得分分别为29.34和29.87。数字0、1、2和5的混合总和超过了混合总数的10%,表明参保和未参保患者对以这些数字结尾的年龄进行了过度选择。未参保和参保患者的惠普尔指数分别为149.3和287.1。这些值分别表明,根据惠普尔指数解释标准,报告的年龄可靠性是粗糙的和非常粗糙的。研究发现,有保险的人比没有保险的人更倾向于关注以0和5结尾的年龄。该研究得出结论,海岸角教学医院的年龄数据是错误报告和不准确的,如果不进行调整,可能导致临床医生采取错误的年龄相关医疗程序。有人建议医院采用创新的方式记录年龄,例如在患者无法回忆起自己的正确年龄时使用历史事件日历技术。
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引用次数: 1
Time Series Analysis and Forecasting of Caesarian Section Births in Ghana 加纳剖宫产的时间序列分析与预测
Pub Date : 2019-07-31 DOI: 10.11648/J.BSI.20190401.11
Bosson-Amedenu Senyefia, Joseph Otoo., Eyiah-Bediako Francis
Caesarian Section (CS) rates have been known to have geographical varaitions. The purpose of this paper was to determine Ghana’s situation (regional trend) and also to provide a two- year forcast estimates for the ten (10) regions of Ghana. The data was longitudinal and comprised monthly CS records of women from 2008 to 2017. The dataset was divided into training and testing dataset. A total of eighty four (84) months were used as the training dataset and the remaining thirty six (36) months were used as testing dataset. The ARIMA methodology was applied in the analysis. Augmented Dicker-Fuller (ADF), KPSS and the Philips-Perron (PP) unit root tests were employed to test for stationarity of the series plot. KPSS (which is known to give more robust results) and PP test consistently showed that the series was stationary (p < 0.05) for all ten (10) regions, although there were some conflicting results with the ADF test for some regions. Tentative models were formulated for each region and the model with the lowest AIC was selected as the “Best” model fit for respective regions of Ghana. The “best” Model fit for Greater Accra, Central and Eastern regions were respectively SARIMA (2, 0, 0) (0, 1, 1)12, SARIMA (2, 0, 0) (0, 1, 1)12 with a Drift and SARIMA (1, 1, 1) (0, 1, 1)12. Additionally, the best model fit for Northern and Volta regions were SARIMA (3,0,2) (0,1,1)12 with drift and SARIMA (0,1,1) (0,1,1)12. Ashanti, Upper East and Western regions failed the JB test or the normality test for the residuals. Upper West and Brong Ahafo Regions were not suitable for forecasting due failure to depict white noise and ARCH test failure, respectively. The best models fit were used to forecast for 2019 and 2020. The results showed that regional variations of CS exist in Ghana. The study recommended for future studies to apply methods that will allow for forecasting for regions which failed the test under the methods used in this study.
剖宫产(CS)的比率已经知道有地理差异。本文的目的是确定加纳的情况(区域趋势),并为加纳的十(10)个地区提供两年的预测估计。这些数据是纵向的,包括2008年至2017年女性的月度CS记录。数据集分为训练数据集和测试数据集。总共84个月作为训练数据集,其余36个月作为测试数据集。采用ARIMA方法进行分析。采用增强型Dicker-Fuller (ADF)、KPSS和Philips-Perron (PP)单位根检验检验序列图的平稳性。KPSS(已知给出更稳健的结果)和PP检验一致表明,该序列在所有10个地区都是平稳的(p < 0.05),尽管在某些地区存在一些与ADF检验相矛盾的结果。为每个区域制定了暂定模型,并选择AIC最低的模型作为适合加纳各自区域的“最佳”模型。适合大阿克拉、中部和东部地区的“最佳”模型分别是SARIMA(2,0,0)(0,1,1)12、SARIMA(2,0,0)(0,1,1)带漂移的12和SARIMA(1,1,1)(0,1,1)12。此外,最适合北方和伏特地区的模型是SARIMA(3,0,2)(0,1,1)12和SARIMA(0,1,1)(0,1,1)12。阿散蒂、上东部和西部地区未通过JB检验或残差正态性检验。Upper West地区和Brong Ahafo地区由于未能描述白噪声和ARCH测试失败而不适合进行预测。最适合的模型用于预测2019年和2020年。结果表明,加纳的CS存在区域差异。该研究建议在未来的研究中应用方法,允许预测在本研究中使用的方法下未通过测试的地区。
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引用次数: 1
Prevalence of Subclinical Mastitis from Milking Dairy Goat Species Reared in Different Climatic Conditions in Morogoro Region 莫罗戈罗地区不同气候条件下饲养的挤奶山羊亚临床乳腺炎患病率
Pub Date : 1900-01-01 DOI: 10.11648/j.bsi.20220701.13
Nyoni Hamis Salum, Katakweba Abdul
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引用次数: 0
Determining Disease Using Machine Learning Algorithm in Medical Image Processing: A Gentle Review 在医学图像处理中使用机器学习算法确定疾病:一个温和的评论
Pub Date : 1900-01-01 DOI: 10.11648/j.bsi.20210604.13
S. Bansal
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引用次数: 0
期刊
Biomedical Statistics and Informatics
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