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Management Recommendations for Prostate Cancer during the COVID-19 pandemic: A Systematic Review 2019冠状病毒病大流行期间前列腺癌管理建议:系统综述
Pub Date : 2021-07-15 DOI: 10.48083/MBSB4196
A. Martínez-Salas, Iñigo Navarro-Ruesga, Erick A. Rodenas-Gil, Jesús Sebastián Muruato-Araiza, Aldo Jiménez-García, I. Reyna-Blanco, J. Morales-Montor, C. Pacheco-Gahbler
Introduction: The COVID-19 pandemic has delayed screening, diagnostic workup, and treatment in prostate cancer (PCa) patients. Our purpose was to review PCa screening, diagnostic workup, active surveillance (AS), radical prostatectomy (RP), radiotherapy (RT), androgen deprivation therapy (ADT) and systemic therapy during theCOVID-19 pandemic.Materials and Methods: We performed a systematic literature search of MEDLINE, EMBASE, Scopus, LILACS, and Web of Science, according to Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols (PRISMA-P) statement for relevant material published from December 2019 to February 2021.Results: Prostate biopsy can be delayed, except when high-risk PCa is suspected or the patient is symptomatic. Active surveillance is appropriate for patients with very low risk, low risk (LR) and favorable intermediate risk (FIR). RP and RT for high risk and very high risk can be safely postponed up to 3 months. Hypofractionated external beamRT (EBRT) is recommended when RT is employed. ADT should be used according to standard PCa-based indications. Chemotherapy should be postponed until the pandemic is contained.Conclusions: The international urological community was not prepared for such an acute and severe pandemic. PCa patients can be adequately managed according to risk stratification. During the COVID-19 pandemic, LR and FIR patients can be followed with active surveillance. Delaying RP and RT in high risk and locally advanced diseaseis justified.
2019冠状病毒病(COVID-19)大流行延迟了前列腺癌(PCa)患者的筛查、诊断和治疗。我们的目的是回顾在2019冠状病毒病大流行期间的前列腺癌筛查、诊断检查、主动监测(AS)、根治性前列腺切除术(RP)、放疗(RT)、雄激素剥夺治疗(ADT)和全身治疗。材料和方法:我们根据2019年12月至2021年2月发表的相关材料的PRISMA-P声明,对MEDLINE、EMBASE、Scopus、LILACS和Web of Science进行了系统的文献检索。结果:前列腺活检可以延迟,除非怀疑有高危前列腺癌或患者有症状。主动监测适用于极低风险、低风险(LR)和有利的中间风险(FIR)患者。高风险和极高风险的RP和RT可以安全地推迟3个月。当采用放射治疗时,建议采用分形外束放射治疗(EBRT)。ADT应根据标准的基于pca的适应症使用。化疗应推迟到疫情得到控制为止。结论:国际泌尿界对如此急性和严重的大流行没有做好准备。前列腺癌患者可以根据风险分层进行适当的管理。在COVID-19大流行期间,可以对LR和FIR患者进行主动监测。在高风险和局部晚期疾病中延迟RP和RT是合理的。
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引用次数: 1
Predictors for Retrograde Ureteral Stenting Failure as an Initial Drainage Method for Emergent Complicated Acute Calculus Obstructive Uropathy 逆行输尿管支架置入术作为急诊复杂急性结石梗阻性尿路病变初始引流方法失败的预测因素
Pub Date : 2021-07-15 DOI: 10.48083/OZUL6913
M. Elbaset, M. Edwan, Rasha T. Abouelkhei, Rawdy Ashour, M. Ramez, Abdalla Abdelhamid, Y. Osman
Objective: To define predictors for initial retrograde ureteral stenting (RUS) failure with the need for the percutaneous nephrostomy (PCN) insertion as a drainage method in patients with complicated acute calculus obstructive uropathy.Methods: We undertook a retrospective evaluation of patients who presented with complicated obstructive calculus uropathy (acute renal failure or obstructive pyelonephritis) between January 2016 and January 2020. Patients in whom there was failure to visualize ipsilateral ureteric orifice and those with extrinsic ureteral obstruction were excluded. Patient demographics and radiological data including stone site, hydronephrosis grade, maximum transverse stone diameter, periureteral density (PUD) and pericalcular ureteric thickness (P-CUT) at the maximum transverse stonediameter were assessed using non-contrast computed tomography at the time of admission.Results: The study included 256 patients who were managed initially by RUS trial. Of them, 48 (18.8 %) had RUS failure. The presence of acute pyelonephritis, increased maximum transverse stone diameter ≥ 9.5 mm, P-CUT ≥ 7.5 mm, and PUD at stone level ≥ 17.5 HU were risk factors associated with RUS failure (P = 0.007, 0.002, < 0.001, and < 0.001, respectively).Conclusion: Initial radiological stone and ureteric characteristics, in addition to the clinical diagnosis of obstructive pyelonephritis, can be used to determine PCN insertion as the preferred option over RUS for urinary drainage.
目的:探讨急性结石梗阻性尿路病变患者需要经皮肾造口术(PCN)引流的初始逆行输尿管支架置入(RUS)失败的预测因素。方法:我们对2016年1月至2020年1月期间出现的复杂阻塞性尿路结石病(急性肾功能衰竭或阻塞性肾盂肾炎)患者进行了回顾性评估。不可见同侧输尿管口及输尿管外源性梗阻者排除。入院时使用非对比计算机断层扫描评估患者人口统计学和影像学资料,包括结石部位、肾积水等级、最大横向结石直径、输尿管周围密度(PUD)和最大横向结石直径处的输尿管周厚度(P-CUT)。结果:研究纳入256例患者,最初采用RUS试验管理。其中48例(18.8%)出现RUS失败。急性肾盂肾炎、最大结石横径≥9.5 mm、P- cut≥7.5 mm、结石水平PUD≥17.5 HU是RUS衰竭的危险因素(P分别为0.007、0.002、< 0.001和< 0.001)。结论:最初的影像学结石和输尿管特征,加上临床诊断为梗阻性肾盂肾炎,可用于确定PCN插入作为泌尿引流的首选方案。
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引用次数: 1
Pyeloduodenal Fistula in Xanthogranulomatous Pyelonephritis 黄色肉芽肿性肾盂肾炎的肾盂十二指肠瘘
Pub Date : 2021-07-15 DOI: 10.48083/NSLU7720
Ryan Yan, Mark T. Dawidek, Drew Phillips, B. Chew
Xanthogranulomatous pyelonephritis (XGP) is a rare but severe form of inflammatory renal disease associated with renal stones and results in granulomatous tissue invading and destroying normal parenchyma. A serious complication of XGP is fistulization to surrounding structures. We present a case of XGP with pyeloduodenal fistula (PDF) in a 48-year-old female with a history of hypertension and recurrent urinary infections but no previous stones.
黄色肉芽肿性肾盂肾炎(XGP)是一种罕见但严重的与肾结石相关的炎症性肾脏疾病,其结果是肉芽肿组织侵入并破坏正常实质。XGP的一个严重并发症是周围结构的瘘管化。我们报告一例XGP合并肾盂十二指肠瘘(PDF)的病例,患者为48岁女性,有高血压病史和尿路感染复发,但既往无结石。
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引用次数: 0
Vesicouterine Fistula in Burkina Faso: Report of 36 Cases in a Multicentric Study 布基纳法索膀胱外瘘:一项多中心研究36例报告
Pub Date : 2021-07-13 DOI: 10.48083/NFMO2987
B. Ouédraogo, B. Kirakoya, M. Kaboré, Adama Millogo, A. Ouattara, F. A. Kaboré
Objective: To report etiological and therapeutic features of vesicouterine fistulas (VUF) in Burkina Faso.Patients and Methods: We performed a retrospective, descriptive, and multicentric study based on the medical records of women treated for VUF from January 2010 to December 2016.Results: VUF accounted for 7.2% (36/497) of urogenital fistulas managed during the study period. The median age of the 36 patients was 35 years (interquartile range = 27 to 37.5 years) with values ranging from 16 years to 64 years old. Among VUF, obstetric fistula accounted for 26 cases (26/36) versus 10 cases (10/36) of iatrogenic fistula.Obstetric VUF were consecutive to emergency Caesarean section (n = 16) and vaginal delivery (n = 10) after prolonged obstructed labor. The 10 cases of iatrogenic VUF were subsequent to prelabour Caesarean section. The main circumstance of VUF occurrence was Caesarean section (26/36). In 10 cases (10/36), VUF was associated with avesicovaginal fistula. Thirty days after the removal of the catheter, the success rate fell from 89% to 80.6%.Conclusion: VUF is rare but its frequency is not negligible in our context. The main circumstance of occurrence remains Caesarean section. The best treatment remains prevention.
目的:报道布基纳法索膀胱外瘘(VUF)的病因和治疗特点。患者和方法:我们基于2010年1月至2016年12月接受VUF治疗的女性的医疗记录进行了一项回顾性、描述性和多中心研究。结果:VUF占研究期间泌尿生殖系统瘘治疗的7.2%(36/497)。36例患者的中位年龄为35岁(四分位数间距为27 ~ 37.5岁),年龄范围为16 ~ 64岁。在VUF中,产科瘘26例(26/36),医源性瘘10例(10/36)。产科VUF连续发生于长时间难产后急诊剖宫产(n = 16)和阴道分娩(n = 10)。10例医源性VUF均为产前剖宫产后发生。发生VUF的主要情况为剖宫产(26/36)。10例(10/36)VUF合并无阴道瘘。拔管30天后,成功率由89%下降到80.6%。结论:VUF是罕见的,但其频率在我们的情况下不容忽视。发生的主要情况仍然是剖腹产。最好的治疗方法仍然是预防。
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引用次数: 1
The Two Faces of Open Access 开放获取的两面
Pub Date : 2021-07-13 DOI: 10.48083/EROK5654
Peter Black
The two faces of open access remain a point of contention in the global world of scientific publishing, and this carries over into the microcosm of urologic publishing. Many of us are part of the research community and all of us are consumers of new research findings. On both sides of the research enterprise—as providers and consumers—our interests are best met by broad dissemination and universal access to all published research. These are the underlying objectives of open access publishing.
开放获取的两个方面仍然是全球科学出版世界的争论点,这延续到泌尿学出版的微观世界。我们中的许多人都是研究界的一员,我们都是新研究成果的消费者。在研究事业的双方——作为提供者和消费者——我们的利益最好通过广泛传播和普遍获取所有已发表的研究来实现。这些都是开放获取出版的潜在目标。
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引用次数: 0
Perioperative Outcomes of Anatomic Endoscopic Enucleation of the Prostate, Robotic and Open Simple Prostatectomy From a Multi-Institutional Database 来自多机构数据库的解剖内窥镜前列腺摘除、机器人和开放式简单前列腺切除术的围手术期结果
Pub Date : 2021-07-13 DOI: 10.48083/LKVV8843
M. Labban, Nassib F. Abou Heidar, V. Misrai, Jad A. Najdi, A. El-Hajj
Objective: To compare the perioperative morbidity of robotic-assisted simple prostatectomy (RASP), anatomical endoscopic enucleation of the prostate (AEEP) and open simple prostatectomy (OSP) for the treatment of benign prostatic obstruction (BPO).Methods: The national surgical quality improvement program database was queried for AEEP, RASP, and OSPprocedures. Clavien-Dindo-graded complications, length of hospital stay (LOS), and operative time were compared among the procedures. To control for the potentially confounding variables, we first conducted a multivariatebackward conditional logistic regression, and then resorted to propensity score matching.Results: We identified 2867 AEEP, 234 RASP, and 1492 OSP procedures. After matching, the risk of pulmonary, renal, infectious, and thromboembolic adverse events was lower after AEEP but not RASP in comparison with OSP (P < 0.05). In comparison with RASP, AEEP had lower cardiac and thromboembolic events (P < 0.05). When comparedwith OSP, AEEP had reduced odds of Clavien-Dindo grade I (OR = 0.12; 95% CI 0.10 to 0.16) and II (OR = 0.38; 95% CI 0.24 to 9.58) complications. Also, AEEP had lower odds for grade I and II as well as grade IV complications (OR = 0.30; 95% CI 0.19 to 0.48, and OR = 0.05; 95% CI 0.01 to 0.24, respectively) compared with RASP.Conclusion: AEEP and RASP were associated with fewer perioperative adverse events, a shorter LOS and a reduced risk of transfusion compared with OSP. AEEP was associated with overall lower complication rates than RASP and OSP.
目的:比较机器人辅助单纯性前列腺切除术(RASP)、解剖内镜下前列腺摘除(AEEP)和开放式单纯性前列腺切除术(OSP)治疗良性前列腺梗阻(BPO)的围手术期发病率。方法:查询国家外科质量改进程序数据库中AEEP、RASP和ospp程序。比较两种手术方式的clavien - dindo分级并发症、住院时间(LOS)和手术时间。为了控制潜在的混淆变量,我们首先进行了多变量反向条件逻辑回归,然后采用倾向得分匹配。结果:AEEP 2867例,RASP 234例,OSP 1492例。配对后,与OSP相比,AEEP组肺部、肾脏、感染性和血栓栓塞性不良事件的风险较低,RASP组的风险较低(P < 0.05)。与RASP相比,AEEP有较低的心脏和血栓栓塞事件(P < 0.05)。与OSP相比,AEEP降低了Clavien-Dindo I级的几率(OR = 0.12;95% CI 0.10 ~ 0.16)和II (OR = 0.38;95% CI 0.24 ~ 9.58)并发症。此外,AEEP发生I级、II级和IV级并发症的几率较低(OR = 0.30;95% CI 0.19 ~ 0.48, OR = 0.05;95% CI分别为0.01 ~ 0.24)。结论:与OSP相比,AEEP和RASP围手术期不良事件更少,LOS更短,输血风险更低。与RASP和OSP相比,AEEP的总体并发症发生率较低。
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引用次数: 1
Evaluation of the Guidelines for Penile Cancer Treatment: Overview and Assessment 阴茎癌治疗指南的评价:概述和评估
Pub Date : 2021-05-13 DOI: 10.48083/TKFP8406
A. Aydh, S. Shariat, R. Motlagh, E. Laukhtina, F. Quhal, K. Mori, H. Mostafaei, A. Necchi, B. Pradère
Introduction: Medical organizations have provided evidence-based guidelines for penile cancer treatment. This current review aims to compare and appraise guidelines on penile cancer treatment to provide a useful summary for clinicians. make an evidence-based approach in the clinical practice.Materials and Methods: We searched in PubMed and Medline for guidelines published between January 1, 2010, and February 1, 2020. The search query terms were “penile cancer,” “penile tumor,” “guidelines,” and “penile malignancy.” In the final analysis, we include the most recent versions of relevant guidelines published in English. The Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument was used to appraise the quality of each guideline.Results: In the final analysis, we included guidelines from the National Comprehensive Cancer Network (updated in 2020), The European Association of Urology (updated in 2018), and The European Society for Medical Oncology (published in 2013). The overall agreement among reviewers was excellent. The range of scores for each domain was as follows: scope and purpose (46% to 61%); stakeholder involvement (33% to 60%); rigor of development (34% to 69%); clarity and presentation (61% to 81%); applicability (33% to 59%) and editorial independence (52% to 78%). The European Association of Urology and National Comprehensive Cancer Network clinical practice guidelines received better scores according to the AGREE II evaluation.Conclusion: Despite the effort made by the guidelines groups to make a practical guideline regarding penile cancer treatment, the actual available evidence is weak. However, we believe our recommendations offer clear guidance.
导读:医疗机构已经为阴茎癌的治疗提供了循证指南。本综述旨在比较和评价阴茎癌治疗指南,为临床医生提供有用的总结。在临床实践中采取循证方法。材料和方法:我们在PubMed和Medline检索了2010年1月1日至2020年2月1日之间发表的指南。搜索关键词是“阴茎癌”、“阴茎肿瘤”、“指南”和“阴茎恶性肿瘤”。在最后的分析中,我们包括最新版本的英文出版的相关指南。研究和评价指南评估II (AGREE II)工具用于评估每个指南的质量。结果:在最终分析中,我们纳入了来自国家综合癌症网络(2020年更新)、欧洲泌尿外科协会(2018年更新)和欧洲肿瘤医学学会(2013年出版)的指南。审稿人的总体意见非常一致。每个领域的得分范围如下:范围和目的(46%至61%);利益相关者参与(33% - 60%);开发的严谨性(34% - 69%);清晰和表达(61% - 81%);适用性(33%至59%)和编辑独立性(52%至78%)。欧洲泌尿外科协会和国家综合癌症网络临床实践指南根据AGREE II评估获得了更好的分数。结论:尽管指南小组为制定阴茎癌治疗的实用指南做出了努力,但实际可用的证据不足。然而,我们相信我们的建议提供了明确的指导。
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引用次数: 1
Long-Term Outcomes Following Surgical Management of Urethral Catheter Injuries in Men With Spinal Cord Injury 男性脊髓损伤患者尿道导管损伤手术治疗后的远期疗效
Pub Date : 2021-05-13 DOI: 10.48083/AGBN5610
Kirtishri Mishra, R. A. Campos, L. Bukavina, R. Gomez
Objective: To evaluate the outcomes of surgical management of men with spina cord injury (SCI) with subsequent catheter damage to the urethra that prevents clean intermittent catheterization (CIC).Methods: We performed a retrospective analysis of male SCI individuals on CIC with catheter-induced urethral injuries who had undergone an operative intervention in the last 30 years at our institution. The offered surgical managements were direct vision internal urethrotomy (DVIU) or urethroplasty (UP). Continent diversion (CDIV) was indicated when reconstruction was not possible.Results: A total of 43 male SCI patients were identified. Median age was 50 years (IQR 41 to 57), and follow-up was 69 months (IQR 34 to 125). Inability to perform CIC was due to urethral stricture (25), false passages (11), fistula (4), diverticulum (2), and urethral erosion (1) . Primary intervention techniques were DVIU, UP, and CDIV. Overall primary success, defined by the ability to return to continent CIC, was 25/43 (58%); secondary surgery (10 CDIV, 3 UP, 1 DVIU) rescued 14/18 failures for a final 91% success rate. Conclusion: Urethral injuries in men with SCI are complex, but individualized continued surgical management can be successful in up to 90% of patients. Therefore, reconstruction should be considered in this population to restore continent intermittent catheterization.
目的:评价男性脊髓损伤(SCI)并发尿道导管损伤导致无法清洁间歇导尿(CIC)的手术治疗效果。方法:我们对我院近30年来接受过手术干预的男性脊髓损伤患者进行了回顾性分析。提供的手术处理是直接视觉内尿道切开术(DVIU)或尿道成形术(UP)。当无法重建时,建议进行大陆分流。结果:共发现43例男性SCI患者。中位年龄50岁(IQR 41 ~ 57),随访69个月(IQR 34 ~ 125)。不能行CIC是由于尿道狭窄(25例)、假通道(11例)、瘘管(4例)、憩室(2例)和尿道糜烂(1例)。主要干预技术为DVIU、UP和CDIV。总体主要成功率(以返回CIC大陆的能力来定义)为25/43 (58%);二次手术(CDIV 10例,UP 3例,DVIU 1例)失败14例/18例,最终成功率91%。结论:男性脊髓损伤的尿道损伤是复杂的,但个性化的持续手术治疗可成功治疗高达90%的患者。因此,在这一人群中应考虑重建,以恢复大陆间断性导尿。
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引用次数: 1
Use of Urology-Based Clinical Practice Guidelines in International Settings 国际泌尿科临床实践指南的使用
Pub Date : 2021-01-18 DOI: 10.48083/QVXE4949
German Patiño, M. Ndoye, H. Thomas, Andrew J. Cohen, Nnenaya A. Mmonu, C. Chu, B. Breyer
ObjectiveClinical practice guidelines (CPGs) serve as frameworks to unify diagnostic criteria and guide clinical decision-making. There is a paucity of literature surrounding the uptake of CPGs in urology practice settings with varied levels of resources worldwide. This study aims to evaluate reported use of CPGs within the context of international urology practice, identify local barriers to uptake, and evaluate the role of stakeholders in the CPG-development process.MethodsThis was an international, multi-center, cross-sectional study. An online survey collecting variables pertaining to the use of CPGs was distributed to attending/consultant urologists in Latin America, Africa, and China. Statistical analysis was conducted using R software.ResultA total of 249 practicing urologists from 28 countries completed the survey. The majority of participants were males, aged 36 to 45, and practiced in a non-academic setting. Ninety-three percent of urologists used CPGs in their everyday clinical practice, and 43% believed CPGs were very important to medical decision-making. However, barriers such as the lack of adaptability or applicability of CPGs to local settings were mentioned by 29% and 24% of participants, respectively. Urologists believed scientific associations (81%), national urology boards (68%), and ministries of health (56%), were important stakeholders to consult to foster the development of local CPGs.ConclusionsGlobally, CPGs are widely used tools for clinical practice. However, there are concerns about the adaptability and applicability of CPGs to settings that may lack the resources to implement their recommendations. Efforts should be directed towards incorporating scientific and medical stakeholders into the review and adaptation of urology CPGs to suit the unique features of local health care systems.
目的临床实践指南(CPGs)是统一诊断标准和指导临床决策的框架。关于在世界范围内不同资源水平的泌尿科实践环境中使用CPGs的文献很少。本研究旨在评估国际泌尿外科实践背景下cpg的使用情况,确定当地使用cpg的障碍,并评估利益相关者在cpg发展过程中的作用。方法本研究为国际性、多中心、横断面研究。一项在线调查收集了与cpg使用有关的变量,并分发给拉丁美洲、非洲和中国的泌尿科主治医师/顾问医师。采用R软件进行统计分析。结果共有来自28个国家的249名泌尿科执业医师完成调查。大多数参与者是男性,年龄在36到45岁之间,在非学术环境中练习。93%的泌尿科医生在日常临床实践中使用CPGs, 43%的人认为CPGs对医疗决策非常重要。然而,29%和24%的参与者分别提到了CPGs对当地环境缺乏适应性或适用性等障碍。泌尿科医生认为科学协会(81%)、国家泌尿科委员会(68%)和卫生部(56%)是促进地方CPGs发展的重要利益相关者。结论在全球范围内,CPGs是临床实践中广泛使用的工具。然而,人们担心cpg对可能缺乏实施其建议的资源的环境的适应性和适用性。应努力将科学和医学利益相关者纳入泌尿科CPGs的审查和调整中,以适应当地卫生保健系统的独特特点。
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引用次数: 2
West Africa Sub-Regional Training and Skills Transfer: My Experience at the Urology Unit of the Korle-Bu Teaching Hospital, Accra, Ghana 西非次区域培训和技能转移:我在加纳阿克拉Korle-Bu教学医院泌尿科的经历
Pub Date : 2021-01-18 DOI: 10.48083/uyeq3443
Surgical training in the West Africa sub-regional countries produces specialist surgeons in most surgical disciplines, including urology, to ensure that people of the sub-region—and sometimes beyond—have access to surgical services. The training is conducted at tertiary health facilities accredited by the national and sub-regional postgraduate colleges.
西非分区域国家的外科培训培养了包括泌尿外科在内的大多数外科学科的专科外科医生,以确保该分区域(有时是其他地区)的人民能够获得外科服务。培训在国家和次区域研究生学院认可的三级保健设施进行。
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引用次数: 0
期刊
Société Internationale d’Urologie Journal
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