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Urothelial Carcinoma Seeding at Site of Nephrostomy 肾造口部位的尿路上皮癌
Pub Date : 2021-11-04 DOI: 10.48083/zvxi1252
Ala'a Farkouh, M. Shahait
No abstract.
没有抽象的。
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引用次数: 0
Management of Men With Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia During and After COVID-19 男性下尿路良性前列腺增生在2019冠状病毒病期间和之后的处理
Pub Date : 2021-11-04 DOI: 10.48083/jtru9739
D. Elterman, J. Baard, M. Averbeck, M. Hassouna, S. Takahashi, I. Chibuzo, A. Sebastianelli, M. Gacci
The lower urinary tract (LUT), in particular the prostate, has been theoretically recognized as a target for SARS-CoV-2. Moreover, common pathophysiological mechanisms have been described for BPE/LUTS and COVID-19, including RAS dysregulation, androgen receptors, and MetS-related factors. These factors raise concerns about the possibility of worse urological outcomes due to BPE/LUTS progression in COVID-19 patients. The available results suggest a correlation between SARS-CoV-2 infection, exacerbation or new onset of LUTS, and semen impairment. BPE patients’ care and management have been deeply affected by COVID-19. In the midst of the pandemic, the main urological guidelines suggested postponement of BPH-related deferrable medical examinations and surgery. Telemedicine, therefore, gained attention and interest. Clinical evidence of impaired QoL or complications expedited surgical intervention. An informed consent covering the risk of COVID-19 and a negative molecular PCR within 72 hours of surgery were mandatory. A reduction in procedures under general anaesthesia was recommended. Long waiting lists accrued worldwide during the pandemic, leading to regular review of the BPE waiting lists and patients’ clinical status, encouraging the increase of minimally invasive office-based procedures, even in the post-COVID-19 era, and the improvement of telemedicine. Prospective studies are still needed to assess the course of LUTS/BPE patients after COVID-19.
下尿路(LUT),特别是前列腺,理论上被认为是SARS-CoV-2的目标。此外,BPE/LUTS和COVID-19的共同病理生理机制已被描述,包括RAS失调、雄激素受体和met相关因素。这些因素引起了人们对COVID-19患者BPE/LUTS进展可能导致泌尿系统预后恶化的担忧。现有结果表明,SARS-CoV-2感染、LUTS加重或新发与精液损伤之间存在相关性。BPE患者的护理和管理受到新冠肺炎疫情的深刻影响。在大流行期间,主要的泌尿学指南建议推迟与bph相关的可延期医疗检查和手术。因此,远程医疗获得了关注和兴趣。生活质量受损或并发症的临床证据加快了手术干预。必须在手术72小时内提供涵盖COVID-19风险的知情同意和阴性分子PCR。建议在全身麻醉下减少手术。大流行期间,全球范围内出现了长时间的等待名单,导致对BPE等待名单和患者临床状况进行定期审查,鼓励了微创办公室手术的增加,即使在covid -19后时代也是如此,并改善了远程医疗。仍需要前瞻性研究来评估COVID-19后LUTS/BPE患者的病程。
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引用次数: 0
Is “Movember” an Effective Prostate Cancer Awareness Campaign Beyond the English Language? Insights From Google Trends Among Spanish Speakers “八字胡十一月”是一个有效的前列腺癌宣传活动吗?西班牙语使用者的谷歌趋势分析
Pub Date : 2021-11-04 DOI: 10.48083/uhsi5324
D. González-Padilla, R. España-Navarro, J. D. Subiela, Raj Kumar, L. G. Medina, J. Aumatell, J. M. De la Morena-Gallego, G. Cacciamani
Objective To evaluate the impact of the “Movember” awareness campaign (men’s health campaign that takes place every November) on internet search trends for information online about prostate cancer and to compare the results with those for “Pinktober” (the breast cancer awareness campaign that takes place in October) in the Spanish language as an indirect measure of its effectiveness. Methods Google Trends was used to evaluate the monthly relative search volumes (RSV) of the terms “cáncer de próstata” (prostate cancer), “cáncer de mama” (breast cancer), and “Movember” from January 2009 to December 2019 both in Spain and worldwide (in the Spanish language). Breast cancer was used as a comparator of the campaign impact. Mean increase in RSV on-campaign and off-campaign was calculated and compared using the Mann-Whitney U test and Joinpoint regression analysis to assess loss or gain of interest. Results The term “cáncer de próstata” showed a statistically significant increase during the campaign months both in Spain (17.4%; P < 0.001) and worldwide (35.4%; P < 0.001). Both “cáncer de próstata” and Movember showed a decreasing trend worldwide and in Spain, while “cáncer de mama” showed an increasing trend. Conclusion The Movember campaign generates a statistically significant increase in the search trends on “cancer de próstata” (prostate cancer) during the month of November (both in Spain and worldwide); when compared with the breast cancer campaign “Pinktober” these increases are of a lesser magnitude but still significant, suggesting that the campaign is effective beyond the English language, although the interest has been decreasing throughout the years.
目的评价“Movember”宣传活动(每年11月开展的男性健康宣传活动)对网上前列腺癌信息搜索趋势的影响,并将其结果与西班牙语“Pinktober”(每年10月开展的乳腺癌宣传活动)的结果进行比较,作为间接衡量其有效性的指标。方法利用谷歌趋势(Google Trends)对2009年1月至2019年12月在西班牙和全球(西班牙语)的“cáncer de próstata”(前列腺癌)、“cáncer de mama”(乳腺癌)和“Movember”三个词的月相对搜索量(RSV)进行评估。乳腺癌被用作运动影响的比较指标。使用Mann-Whitney U检验和Joinpoint回归分析来计算和比较活动前后RSV的平均增加,以评估兴趣的损失或获得。结果在西班牙,“cáncer de próstata”一词在竞选期间的使用频率显著增加(17.4%;P < 0.001)和全世界(35.4%;P < 0.001)。“cáncer de próstata”和“Movember”在全球和西班牙均呈现下降趋势,而“cáncer de mama”呈现上升趋势。在11月份(西班牙和世界范围内),“胡子月”活动对“cancer de próstata”(前列腺癌)的搜索趋势产生了统计上的显著增长;与乳腺癌运动“粉红十月”相比,这些增长幅度较小,但仍然很重要,这表明该运动在英语之外也有效,尽管多年来人们的兴趣一直在下降。
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引用次数: 2
Expert Roundtable Discussion on Penile Prosthesis Infection Prevention Measures 阴茎假体感染预防措施专家圆桌讨论
Pub Date : 2021-11-04 DOI: 10.48083/gvcc5010
E. Chung, M. Gross, K. van Renterghem, J. Simhan
No abstract.
没有抽象的。
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引用次数: 1
Protocol for a Pilot Study of the NODE Trial, a Prospective Multicentre Randomised Trial of Extended Pelvic Lymph Node Dissection for High-Risk Prostate Cancer NODE试验的试点研究方案,这是一项前瞻性多中心随机试验,用于扩展盆腔淋巴结清扫治疗高危前列腺癌
Pub Date : 2021-11-04 DOI: 10.48083/hahe3801
G. McClintock, Hadia Khanani, A. de Rosa, S. Leslie, N. Ahmadi, J. Fallot, P. Ferguson, H. Woo
Objectives To test the hypothesis that a randomised trial of extended pelvic lymph node dissection (ePLND) can recruit at a rate acceptable for a larger scale trial. To compare the following secondary endpoints between the 2 arms: the rate of protocol violations, the intraoperative and postoperative morbidity of ePLND, and complications, and to evaluate short-term oncological outcomes comparing biochemical recurrence, clinical recurrence, and survival between arms. Patients and Methods A pilot study will be undertaken at Chris O’Brien Lifehouse and Royal Prince Alfred Hospitals for the NODE trial. Twenty patients will be randomised 1:1 to radical prostatectomy with or withoutePLND. Eligible participants will have high-risk prostate cancer and will be scheduled for robotic radical prostatectomy. High-risk disease will be defined as in the 2019 NCCN guidelines (stage ≥ T3a, ISUP Grade Group ≥ 4 or PSA ≥ 20ng/mL). PSMA PET/CT staging not showing any extraprostatic disease will be required. Quality control measures to ensure consistent delivery of high-quality extended lymph node dissections are in place,and surgeons have been selected for their consistent ability to perform such procedures. Results The trial is currently underway. Conclusion On current available evidence, it is unclear if ePLND provides additional benefit over radicalprostatectomy.
目的验证一项扩大盆腔淋巴结清扫(ePLND)的随机试验是否能够以可接受的速率进行更大规模的试验。比较两组间的以下次要终点:方案违反率、术中和术后ePLND的发病率和并发症,并比较两组间生化复发、临床复发和生存率的短期肿瘤预后。患者和方法将在Chris O 'Brien Lifehouse和Royal Prince Alfred医院进行NODE试验的试点研究。20名患者将按1:1随机分组,接受根治性前列腺切除术,伴或不伴plnd。符合条件的参与者将患有高风险前列腺癌,并将计划进行机器人根治性前列腺切除术。高危疾病将在2019年NCCN指南中定义(分期≥T3a, ISUP分级组≥4或PSA≥20ng/mL)。PSMA PET/CT分期未显示前列腺外病变。质量控制措施,以确保持续交付高质量的延伸淋巴结清扫是到位的,外科医生已经选择了他们一贯的能力来执行这类程序。试验目前正在进行中。结论根据现有证据,尚不清楚ePLND是否比根治性前列腺切除术有更多的益处。
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引用次数: 1
Private Practice in Jordan 约旦的私人诊所
Pub Date : 2021-11-04 DOI: 10.48083/ahop2343
Zeid Abughosh
No abstract.
没有抽象的。
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引用次数: 0
Ambulatory Urodynamic Findings Change Patient Outcomes 动态尿动力学结果改变患者预后
Pub Date : 2021-11-04 DOI: 10.48083/mhmi1178
R. Axell, V. Guzelburc, H. Yasmin*, B. Toia, M. Pakzad, R. Hamid, J. Ockrim, T. Greenwell
Objectives Whilst ambulatory urodynamics (aUDS) may be used as a second-stage test for patients with refractory lower urinary tract symptoms (LUTS) having non-diagnostic conventional urodynamics (UDS), the evidence for their use is limited. We have assessed the diagnostic utility and consequent symptomatic outcome of aUDS in patients with refractory LUTS. Methods A retrospective review of a prospectively acquired urodynamics database was made of 84 consecutive patients (23 male) with a median age 50.5 years (range 18 to 79) having aUDS following non-diagnostic or contradictory baseline UDS over a 12-month period. Patient demographics and urodynamic and clinical diagnosis before and after aUDS were recorded. Forty-six patients (55%) had formal urinary symptom assessment recorded before and a minimum of 6 months following aUDS-related change in management. Results Eighty-two patients (98%) had a urodynamic diagnosis made following aUDS, 57(68%) of whom had detrusor overactivity (DO); the final 2 patients had no abnormalities detected on aUDS. Change in primary UDS diagnosis occurred in 66 patients (79%). Of these 66 patients, 59 (89%) also had their clinical diagnosis changed, and 55 (83%) had their management pathway changed. There was a significant improvement in urinary symptoms 6 months following aUDS. Conclusion Change in primary diagnosis following aUDS led to a significant change in treatment care pathway and resulted in significant improvement in urinary symptoms.
虽然动态尿动力学(aUDS)可作为难治性下尿路症状(LUTS)患者的第二阶段检查,但常规尿动力学(UDS)无法诊断,但其使用的证据有限。我们评估了aUDS在难治性LUTS患者中的诊断效用和随之而来的症状结局。方法回顾性分析前瞻性获得的尿动力学数据库,包括84例连续患者(23例男性),中位年龄50.5岁(18 - 79岁),在12个月的时间里,在非诊断性或矛盾基线UDS下发生aUDS。记录aUDS前后患者人口统计学、尿动力学和临床诊断。46例患者(55%)在auds相关治疗改变前和改变后至少6个月进行了正式的泌尿系统症状评估。结果aUDS后尿动力学诊断为82例(98%),其中57例(68%)存在逼尿肌过度活动(DO);最后2例患者在aUDS上未发现异常。66例患者(79%)发生了原发性UDS诊断的改变。在这66例患者中,59例(89%)的临床诊断发生了改变,55例(83%)的治疗途径发生了改变。aUDS后6个月泌尿系统症状有显著改善。结论aUDS后原发性诊断的改变导致治疗护理途径的显著改变,导致泌尿系统症状的显著改善。
{"title":"Ambulatory Urodynamic Findings Change Patient Outcomes","authors":"R. Axell, V. Guzelburc, H. Yasmin*, B. Toia, M. Pakzad, R. Hamid, J. Ockrim, T. Greenwell","doi":"10.48083/mhmi1178","DOIUrl":"https://doi.org/10.48083/mhmi1178","url":null,"abstract":"Objectives Whilst ambulatory urodynamics (aUDS) may be used as a second-stage test for patients with refractory lower urinary tract symptoms (LUTS) having non-diagnostic conventional urodynamics (UDS), the evidence for their use is limited. We have assessed the diagnostic utility and consequent symptomatic outcome of aUDS in patients with refractory LUTS. Methods A retrospective review of a prospectively acquired urodynamics database was made of 84 consecutive patients (23 male) with a median age 50.5 years (range 18 to 79) having aUDS following non-diagnostic or contradictory baseline UDS over a 12-month period. Patient demographics and urodynamic and clinical diagnosis before and after aUDS were recorded. Forty-six patients (55%) had formal urinary symptom assessment recorded before and a minimum of 6 months following aUDS-related change in management. Results Eighty-two patients (98%) had a urodynamic diagnosis made following aUDS, 57(68%) of whom had detrusor overactivity (DO); the final 2 patients had no abnormalities detected on aUDS. Change in primary UDS diagnosis occurred in 66 patients (79%). Of these 66 patients, 59 (89%) also had their clinical diagnosis changed, and 55 (83%) had their management pathway changed. There was a significant improvement in urinary symptoms 6 months following aUDS. Conclusion Change in primary diagnosis following aUDS led to a significant change in treatment care pathway and resulted in significant improvement in urinary symptoms.","PeriodicalId":21961,"journal":{"name":"Société Internationale d’Urologie Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81434176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Adult Retroperitoneal Sarcoma: A Comprehensive Genomic Profiling Study 原发性成人腹膜后肉瘤:一项全面的基因组分析研究
Pub Date : 2021-07-15 DOI: 10.48083/VOGF2319
A. Necchi, Giuseppe Basile, F. Pederzoli, M. Bandini, P. Grivas, G. Bratslavsky, P. Spiess, J. Killian, D. Lin, E. Williams, S. Ramkissoon, E. Severson, B. Alexander, J. Venstrom, P. Reddy, Kimberley McGregor, J. Elvin, A. Schrock, D. Pavlick, D. Jin, S. Trabucco, Natalie Danzinger, J. Ross
Background: Adult primary retroperitoneal sarcomas (RPSs) are a group of heterogeneous tumors with different histological subtypes. Comprehensive genomic profiling (CGP) analyses have recently provided significant insights into the biology of sarcomas by identifying genomic alterations (GAs) which could benefit from targeted therapies.Methods: RPS were evaluated by CGP using next-generation sequencing of up to 406 cancer-related genes. Tumor mutational burden (TMB) was determined on 0.83 to 1.14 mut/Mb of sequenced DNA. Finally, PD-L1 expression was determined.Results: Overall, 296 cases of primary RPS were analyzed. Liposarcoma (LPS) subtype had more GA/tumor than leiomyosarcoma (LMS) subtypes, with follicular dendritic cell sarcomas harboring the highest and synovial sarcomas the lowest. TP53 and Rb1 alterations were the highest in LMS, and CDK4/6 and MDM2 in LPS. However, both theTMB and targetable GA rates were low across subtypes. PD-L1 immunostaining was low positive in 21% and high positive in 5% of patients, respectively.Conclusions: CGP analysis revealed that potentially actionable genomic targets were rare in our cohort of RPS. Moreover, RPSs seem less likely to respond to immune checkpoint inhibitors based on putative biomarkers status. Nevertheless, genomic stratification according to histological subtypes led to description of GAs that can inform future clinical trials design.
背景:成人原发性腹膜后肉瘤(rps)是一组具有不同组织学亚型的异质性肿瘤。综合基因组谱分析(CGP)最近通过鉴定基因组改变(GAs)为肉瘤生物学提供了重要的见解,这些改变可以从靶向治疗中受益。方法:采用CGP对多达406个癌症相关基因进行下一代测序,评估RPS。肿瘤突变负荷(TMB)测定为0.83 ~ 1.14 mut/Mb。最后,测定PD-L1的表达。结果:共分析296例原发性RPS。脂肉瘤(LPS)亚型比平滑肌肉瘤(LMS)亚型有更多的GA/肿瘤,其中滤泡树突状细胞肉瘤发生率最高,滑膜肉瘤发生率最低。LMS中TP53和Rb1的改变最高,LPS中CDK4/6和MDM2的改变最高。然而,tmb和靶向GA率在不同亚型中都很低。PD-L1免疫染色低阳性占21%,高阳性占5%。结论:CGP分析显示,在我们的RPS队列中,潜在可操作的基因组靶点很少。此外,基于假定的生物标志物状态,RPSs似乎不太可能对免疫检查点抑制剂产生反应。然而,根据组织学亚型的基因组分层导致GAs的描述,可以为未来的临床试验设计提供信息。
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引用次数: 1
The Right Instrument for the Right Purpose: Spreading the Use of Small Caliber Ureteroscope for the Inspection of the Male and Female Urethra 正确的器械,正确的目的:推广小口径输尿管镜在男女尿道检查中的应用
Pub Date : 2021-07-15 DOI: 10.48083/NVKO4969
S. Kulkarni, M. Bandini, Amey Y. Patil, S. Bhadranavar, Vipin Sharma, S. Bafna, S. L. Yatam, G. Barbagli, F. Montorsi, P. Joshi
The inspection of the urethra in patients with documented or suspected urethral stricture should be carried out with small caliber ureteroscope of 6/7.5Ch. Different from flexible cystoscope (16Ch) or resectoscope (26Ch), small caliber ureteroscope allows a comprehensive evaluation of the stricture, including its length and the status of the mucosa in its proximity, without injuring or overstretching the urethra. With a small caliber ureteroscope it is also possible to cross the stricture, allowing the evaluation of the proximal urethra, the external urethral sphincter, and the bladder. A 6/7.5Ch ureteroscope also allows estimation of the real caliber of the stricture, providing a useful landmark for further treatment decisions.
有证实或怀疑尿道狭窄的患者应行6/7.5Ch小口径输尿管镜检查尿道。与柔性膀胱镜(16Ch)或切除镜(26Ch)不同,小口径输尿管镜可以在不损伤或过度拉伸尿道的情况下,对狭窄进行全面评估,包括狭窄的长度和邻近粘膜的状况。小口径输尿管镜也可以穿过狭窄,对近端尿道、外尿道括约肌和膀胱进行检查。6/7.5 cm输尿管镜还可以估计狭窄的真实口径,为进一步的治疗决策提供有用的里程碑。
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引用次数: 4
Effect of Metallic Ureteric Stents on Magnetic Resonance Imaging: Implications for Malignant Ureteral Obstruction 金属输尿管支架对磁共振成像的影响:对恶性输尿管梗阻的影响
Pub Date : 2021-07-15 DOI: 10.48083/WLVR1509
Mahima Tellambura, I. Thangasamy, Kwang Y. Chin, D. Murphy
Metallic ureteric stents are increasingly used for the management of malignant ureteric obstruction, a commonly encountered complication in urological and other malignancies. However, there has been limited evaluation of complications associated with these stents, including those that might arise from the use of magnetic resonance imaging (MRI). While most devices are deemed nominally “MRI-safe,” their implication on the quality of imagingproduced has not been evaluated in clinical trials, and in our practice, significant artefact has been encountered with some ureteric stents—specifically, the Teleflex Rüsch DD tumour stent—compromising image quality and diagnostic certainty.
金属输尿管支架越来越多地用于治疗恶性输尿管梗阻,这是泌尿外科和其他恶性肿瘤中常见的并发症。然而,对这些支架相关并发症的评估有限,包括使用磁共振成像(MRI)可能引起的并发症。虽然大多数设备在名义上被认为是“mri安全的”,但它们对成像质量的影响尚未在临床试验中进行评估,而且在我们的实践中,一些输尿管支架(特别是Teleflex rsch DD肿瘤支架)遇到了明显的伪影,影响了图像质量和诊断的确定性。
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引用次数: 1
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Société Internationale d’Urologie Journal
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