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Evaluating initial screening practices for calcium dysregulation after acute traumatic spinal cord injury: a retrospective review. 评估急性创伤性脊髓损伤后钙失调的初步筛查方法:回顾性研究。
IF 0.7 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-31 DOI: 10.1038/s41394-024-00663-0
Rajbir Chaggar, Ranjodh Gill

Objectives: The purpose of this study was to determine the frequency of which calcium homeostasis markers are obtained in the acute setting after an initial traumatic spinal cord injury (TSCI).

Design: Retrospective chart review of a limited data set linking ICD 10 codes designating TSCI to corresponding calcium homeostasis markers for patients with an initial chart encounter for TSCI.

Setting: A level 1 trauma center in Virginia, United States METHODS: The statistical software SPSS was used to calculate summary statistics including frequency, mean, and standard deviation for calcium homeostasis markers (basic metabolic panel, magnesium, spot urine calcium, testosterone panel, liver function tests, Vitamin D level, C-telopeptide, parathyroid hormone, celiac panel, DXA imaging report) as well as the mean and standard deviation for time to first check of the marker.

Results: Most markers were not obtained besides calcium. Only 10 of 80 (12.5%) of subjects had a Vitamin D level (mean 28, SD 23) checked during acute admission (mean days to check 1.5, SD 1.6), with most other markers checked much less frequently.

Conclusions: Most calcium homeostasis markers were not checked on acute admission after TSCI. Future studies on implementing a standardized calcium homeostasis marker protocol for monitoring and potential medical intervention should be explored.

研究目的本研究旨在确定在初次创伤性脊髓损伤(TSCI)后的急性期获得钙稳态标记物的频率:对有限的数据集进行回顾性病历审查,将指定 TSCI 的 ICD 10 编码与首次病历会诊的 TSCI 患者的相应钙稳态标记物联系起来:方法:使用统计软件SPSS计算钙平衡指标(基础代谢全套指标、镁、定点尿钙、睾酮全套指标、肝功能检查、维生素D水平、C-髓肽、甲状旁腺激素、乳糜泻全套指标、DXA成像报告)的频率、平均值和标准差等汇总统计,以及首次检查指标时间的平均值和标准差:结果:除血钙外,大多数指标均未获得。80名受试者中只有10人(12.5%)在急性入院期间检查过维生素D水平(平均28,标准差23)(平均检查天数1.5,标准差1.6),其他大多数指标的检查频率要低得多:结论:大多数钙平衡指标都没有在 TSCI 患者急性入院时进行检查。结论:大多数钙平衡指标在 TSCI 急性入院时都没有检查过,今后应探索实施标准化的钙平衡指标方案,以进行监测和潜在的医疗干预。
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引用次数: 0
Enhancing balance and mobility in incomplete spinal cord injury with an overground gait trainer. 利用地面步态训练器增强不完全脊髓损伤患者的平衡能力和活动能力。
IF 0.7 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-29 DOI: 10.1038/s41394-024-00668-9
Meriç Selim Şipal, Sinem Yıldırım, Meltem Güneş Akıncı, Sezen Dincer, Müfit Akyüz

Study design: Prospective intervention study.

Objectives: The study aimed to assess the effect of Andago on balance, overground walking speed, independence levels, fear of falling, and quality of life in patients with acute motor incomplete Spinal Cord Injury.

Setting: The study was conducted in Ankara/Türkiye.

Methods: Five participants, classified as AIS D, underwent an eight-week treatment regimen, including three days a week of Andago-assisted walking and balance exercises, supplemented by two days a week of 40-minute sessions of conventional in-bed exercises.

Results: Berg Balance Scale scores increased significantly by 129% (p = 0.043). Overground walking speed calculated from 10MWT improved by 33% (p = 0.042). WISCI II levels improved significantly compared to baseline scores (p = 0.041). In the mobility subscale of SCIM III, the total SCIM III scores increased significantly (p = 0.042, p = 0.043, respectively). However, there was no significant improvement in WHOQOL-BREF scores (p = 0.080).

Conclusions: The use of Andago facilitated functional progress in patients with acute incomplete SCI, emphasizing the importance of challenging balance and walking activities in triggering motor learning.

研究设计前瞻性干预研究:研究旨在评估Andago对急性运动性不完全脊髓损伤患者的平衡能力、地面行走速度、独立性水平、跌倒恐惧和生活质量的影响:研究在土耳其安卡拉进行:五名被归类为 AIS D 级的参与者接受了为期八周的治疗,包括每周三天的安达哥辅助行走和平衡练习,以及每周两天的 40 分钟常规床上练习:结果:Berg 平衡量表评分显著提高了 129% (p = 0.043)。根据 10MWT 计算得出的地面行走速度提高了 33% (p = 0.042)。与基线分数相比,WISCI II 水平明显提高(p = 0.041)。在 SCIM III 的行动能力分量表中,SCIM III 的总分显著增加(分别为 p = 0.042 和 p = 0.043)。然而,WHOQOL-BREF评分没有明显改善(p = 0.080):结论:Andago的使用促进了急性不完全脊髓损伤患者的功能进展,强调了具有挑战性的平衡和行走活动在引发运动学习方面的重要性。
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引用次数: 0
Intrathecal baclofen therapy for spasticity in a person with spinal cord injury and end-stage renal disease dependent on hemodialysis: a case report 鞘内巴氯芬治疗脊髓损伤和依赖血液透析的终末期肾病患者的痉挛:病例报告
IF 1.2 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-28 DOI: 10.1038/s41394-024-00666-x
Radha Korupolu

Introduction

Spasticity is one of the most common secondary complications following a spinal cord injury (SCI), which can significantly debilitate a patient irrespective of the severity of the injury. Intrathecal baclofen therapy can effectively reduce global spasticity in bilateral lower extremities at lower doses and allows precise dose titration to manage spasticity optimally. In complex patients with spasticity and multiple medical comorbidities, multidisciplinary teamwork is required to assess ITB safety and deliver timely intervention to prevent secondary complications of spasticity and improve quality of life.

Case presentation

A 61-year-old African American male with multiple comorbidities, including end-stage renal disease (ESRD) requiring dialysis sustained non-traumatic SCI due to epidural abscess resulting in paraplegia and severe debilitating spasticity. Spasticity gradually worsened and interfered with his ability to achieve independence with functional activities appropriate for his neurological level of injury. A multidisciplinary team approach in this complex case resulted in a successful ITB trial and subsequent ITB implantation, resulting in reduced spasticity and improved quality of life. To our knowledge, this is the first case report of the administration of intrathecal baclofen pump therapy in a person with SCI and end-stage renal disease (ESRD) dependent on hemodialysis.

Discussion

ITB therapy can be safely delivered in a person with SCI and multiple medical comorbidities, including ESRD, dependent on hemodialysis to manage spasticity. However, a careful evaluation and discussion among the multidisciplinary team managing the patient’s morbidities and patient is required to assess the risks and benefits of ITB therapy to allow the patient to make an informed decision.

导言痉挛是脊髓损伤(SCI)后最常见的继发性并发症之一,无论损伤的严重程度如何,都会严重削弱患者的能力。鞘内巴氯芬疗法可以在较低剂量下有效减轻双侧下肢的全面痉挛,并且可以通过精确的剂量滴定来对痉挛进行最佳控制。病例介绍 一位 61 岁的非裔美国男性,患有多种并发症,包括需要透析的终末期肾病(ESRD),因硬膜外脓肿导致非外伤性 SCI,造成截瘫和严重的衰弱性痉挛。痉挛逐渐恶化,影响了他独立从事与其神经损伤程度相适应的功能活动的能力。在这个复杂的病例中,多学科团队成功地进行了 ITB 试验,并在随后植入了 ITB,从而减轻了痉挛,提高了生活质量。据我们所知,这是第一例在依赖血液透析的 SCI 和终末期肾病(ESRD)患者中使用鞘内巴氯芬泵治疗的病例报告。讨论对于依赖血液透析的 SCI 和多种并发症(包括 ESRD)患者,可以安全地使用 ITB 治疗来控制痉挛。但是,管理患者病症的多学科团队和患者之间需要进行仔细评估和讨论,以评估 ITB 治疗的风险和益处,从而让患者做出知情决定。
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引用次数: 0
Occlusion of vertebral artery and anterior spinal artery in cervical facet dislocation: a prospective study using computed tomography angiography. 颈椎面脱位时椎动脉和脊髓前动脉闭塞:一项使用计算机断层扫描血管造影术进行的前瞻性研究。
IF 0.7 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-23 DOI: 10.1038/s41394-024-00664-z
Zhengfeng Zhang

Study design: A prospective study.

Objective: To investigate the incidence of vertebral artery (VA) occlusion and whether anterior spinal artery (ASA) is occluded in cervical facet dislocation.

Setting: University hospital, China.

Methods: During a 2-year period, 21 conventional patients with cervical facet dislocation were prospectively enrolled. All patients received computed tomography angiography (CTA) to assess the patency of the VA, anterior radiculomedullary arteries (ARAs), and ASA at the time of injury. Clinical data were documented, including demographics, symptomatic vertebrobasilar ischemia, American Spinal Injury Association Impairment Scale (ASIA) grades, and ASA and VA radiological characteristics.

Results: VA unilateral occlusion occurred in 5 of 21 patients (24%), including 2 with unilateral facet dislocation and 3 with bilateral facet dislocation. No ASA occlusion was found in all 21 patients, including 5 with VA unilateral occlusion. No patients had symptomatic vertebrobasilar ischemia.

Conclusions: VA occlusion occurs in approximately one-fourth of cervical facet dislocations, with infrequent symptomatic vertebrobasilar ischemia. ASA is not occluded following cervical facet dislocation, even with unilateral VA occlusion.

研究设计前瞻性研究:调查椎动脉(VA)闭塞的发生率以及颈椎面脱位时脊髓前动脉(ASA)是否闭塞:地点:中国大学附属医院:方法:在两年时间内,前瞻性地选取了21例常规颈椎椎间盘脱位患者。所有患者均接受了计算机断层扫描血管造影术(CTA),以评估受伤时VA、前桡髓动脉(ARA)和ASA的通畅情况。记录的临床数据包括人口统计学、无症状椎基底动脉缺血、美国脊柱损伤协会损伤量表(ASIA)分级、ASA和VA放射学特征:21例患者中有5例(24%)发生了VA单侧闭塞,其中2例为单侧面脱位,3例为双侧面脱位。所有21名患者均未发现ASA闭塞,其中包括5名VA单侧闭塞患者。没有患者出现有症状的椎基底动脉缺血:结论:大约四分之一的颈椎面脱位患者会出现VA闭塞,但很少出现症状性椎基底动脉缺血。即使单侧VA闭塞,颈椎面脱位后ASA也不会闭塞。
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引用次数: 0
A rare case of spinal involvement in hereditary hemorrhagic telangiectasia. 遗传性出血性毛细血管扩张症脊柱受累的罕见病例。
IF 0.7 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-17 DOI: 10.1038/s41394-024-00662-1
V Hvingelby, Ronni Mikkelsen, Gudrun Gudmundsdottir, Marlene Andersen, Ellen Merete Hagen

Introduction: Here, we describe a rare case of a spinal arteriovenous fistula in a patient with known hereditary hemorrhagic telangiectasia (HHT) and spontaneous intraspinal hemorrhage. Furthermore, we provide a brief review of the literature on the formation of spinal arteriovenous malformations (AVM) in relation to this disease.

Case presentation: The case involves a 54-year-old male with known HHT. At the age of 49, the patient experienced recurrent cystitis. Urological evaluation ruled the cause to be neurological and subsequent imaging revealed a thoracic AVM. Four years later, the patient was admitted to A&E with chest pain and loss of function of the lower extremities and right arm, suspicious for ruptured aortic dissection. Trauma-CT excluded this and a final diagnosis of ruptured spinal AVM was made. Seven months post-injury, a spinal angiography was performed confirming the AVM. The remaining AVM was embolized under general anesthesia with acceptable results.

Discussion: Spinal involvement in HHT is exceedingly rare but remains an important differential diagnosis, especially when patients present autonomic symptoms as these could potentially progress to life-threatening complications. The literature and the presented case indicate the prudence of closing spinal AVMs in HHT in case of symptoms, including autonomic, such as bladder dysfunction.

导言:在此,我们描述了一例罕见的脊髓动静脉瘘病例,患者患有已知的遗传性出血性毛细血管扩张症(HHT)和自发性椎管内出血。此外,我们还简要回顾了与这种疾病相关的脊髓动静脉畸形(AVM)形成的文献:本病例涉及一名 54 岁男性,已知患有 HHT。患者在 49 岁时出现反复膀胱炎。泌尿科评估认为病因是神经系统疾病,随后的影像学检查发现了胸部动静脉畸形。四年后,患者因胸痛、下肢和右臂功能丧失被送入急诊室,怀疑主动脉夹层破裂。创伤计算机断层扫描排除了这一可能性,最终诊断为脊髓动静脉畸形破裂。伤后七个月,进行了脊髓血管造影检查,证实了 AVM 的存在。在全身麻醉的情况下,对剩余的 AVM 进行了栓塞,效果尚可:讨论:脊髓受累在 HHT 中极为罕见,但仍是一个重要的鉴别诊断,尤其是当患者出现自主神经症状时,因为这些症状有可能发展为危及生命的并发症。文献和本病例表明,在 HHT 患者出现包括自主神经症状(如膀胱功能障碍)时,应谨慎关闭脊髓动静脉畸形。
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引用次数: 0
Pure epidural extraosseous cavernous hemangioma with thoracic myelopathy: case report and review of literature. 纯硬膜外海绵状血管瘤伴胸椎脊髓病:病例报告和文献综述。
IF 0.7 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-15 DOI: 10.1038/s41394-024-00655-0
Jordan Guntin, Ashley Ricciardelli, Alex Flores, Jeffrey Chen, Jeffrey Treiber, Alfonso Fuentes

Introduction: Pure epidural spinal cavernous hemangiomas are rare, benign vascular tumors that account for approximately 4% of all spinal epidural tumors. Due to their dumbbell shape and propensity for foraminal invasion, they are often misdiagnosed and inadequately treated. We present a case of a 58-year-old male with extra-osseous cavernous hemangioma to better aid in diagnosis and management of these lesions.

Case presentation: A 58-year-old male presented with chronic lower back pain, progressive lower extremity weakness, T10 sensory level, absent lower extremity proprioception, hyperreflexia, and an episode of bowel incontinence. Imaging demonstrated T7-T10 homogenous dorsal epidural mass causing cord signal change. He underwent resection with histopathologic exam revealing a pure epidural cavernous hemangioma.

Conclusion: Spinal epidural cavernous hemangiomas are exceedingly rare lesions that are often misdiagnosed as nerve sheath tumors and meningiomas. Common features include chronic pain and myelopathy as well as T1 isodensity, T2 hyperintensity, and homogenous enhancement. Uniquely, they present as a lobulated, spindled shape with tapered ends in the dorsal epidural space. Both gross and subtotal resection result in favorable neurologic outcomes.

导言:纯硬膜外脊髓海绵状血管瘤是一种罕见的良性血管肿瘤,约占所有脊髓硬膜外肿瘤的 4%。由于其形状呈哑铃状,且易侵犯椎管韧带,因此常常被误诊,且治疗不当。我们介绍了一例 58 岁男性骨外海绵状血管瘤患者的病例,以更好地帮助诊断和治疗这些病变:一名 58 岁的男性因慢性下背痛、进行性下肢无力、T10 感觉水平、下肢本体感觉缺失、反射亢进和一次大便失禁而就诊。影像学检查显示,T7-T10 均质背侧硬膜外肿块导致脊髓信号改变。他接受了切除手术,组织病理学检查显示为纯硬膜外海绵状血管瘤:脊髓硬膜外海绵状血管瘤是极为罕见的病变,常被误诊为神经鞘瘤和脑膜瘤。其共同特征包括慢性疼痛和脊髓病,以及 T1 等密度、T2 高密度和均匀强化。与众不同的是,它们在背侧硬膜外腔呈分叶状、纺锤形,末端呈锥形。大体切除和次全切除均可获得良好的神经功能预后。
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引用次数: 0
Bedside electromyography for clinical assessment of sacral motor and reflex activity adapted for patients hospitalized with acute neurological conditions: a pilot study. 床旁肌电图用于临床评估骶骨运动和反射活动,适用于急性神经系统疾病住院患者:一项试点研究。
IF 0.7 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-13 DOI: 10.1038/s41394-024-00657-y
Maude Duguay, Jean-Marc Mac-Thiong, Andréane Richard-Denis

Study design: Pilot cohort study.

Objective: To develop and implement a sacral electromyographic (sEMG) technique at bedside to ascertain sparing of sacral motor activity and reflexes in patients hospitalized for acute neurological conditions.

Setting: Hôpital du Sacré-Coeur de Montréal a Canadian Level-1 university trauma center specialized in SCI care.

Methods: Nine patients underwent digital rectal examination (DRE) and sEMG, assessing voluntary anal contraction and sacral spinal reflexes (bulbocavernosus reflex and the anal wink). Our sEMG technique utilized surface recording electrodes and tactile elicitation of reflexes. EMG signal was acquired at bedside through the Noraxon MR3 system.

Results: It was quick, well accepted and did no harm. We found that contrary to the DRE, sEMG detected subclinical sacral motor activity and reflexes in 20% of cases for voluntary anal contraction and 40% of cases for the anal wink.

Conclusion: We believe our sEMG technique is a powerful tool able to enhance management of patients suffering from acute neurological impairments and requiring sacral function assessment.

研究设计试验性队列研究:开发并实施床旁骶骨肌电图(sEMG)技术,以确定急性神经系统疾病住院患者的骶骨运动活动和反射是否得到保护:蒙特利尔圣心医院(Hôpital du Sacré-Coeur de Montréal):加拿大一级大学创伤中心,专门从事 SCI 护理:九名患者接受了数字直肠检查 (DRE) 和 sEMG,评估肛门自主收缩和骶脊反射(球海绵体反射和肛门眨眼)。我们的肌电图技术利用表面记录电极和触觉激发反射。EMG 信号通过 Noraxon MR3 系统在床旁采集:结果:这种方法快速、易于接受,而且不会造成任何伤害。我们发现,与 DRE 相反,sEMG 在 20% 的肛门自主收缩和 40% 的肛门眨眼病例中检测到了亚临床骶骨运动活动和反射:我们相信,我们的 sEMG 技术是一种强大的工具,能够加强对患有急性神经损伤并需要进行骶骨功能评估的患者的管理。
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引用次数: 0
Complications in spinal cord injury persons with "traditional" colostomy: a case series. 使用 "传统 "结肠造口术的脊髓损伤患者的并发症:病例系列。
IF 0.7 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-12 DOI: 10.1038/s41394-024-00660-3
Luca Negosanti, Mimosa Balloni, Siriana Landi, Elisa Mercante, Davide Villa, Rossella Sgarzani

Introduction: Neurogenic bowel dysfunction is a frequent consequence of spinal cord injury/disease (SCI/D). A colostomy is considered when conservative treatments fail [1, 2]. In the last year we observed several SCI/D persons with colostomy, admitted to our institution with multiple complications.

Case presentation: We present four cases of SCI/D persons treated with Hartmann's procedure and admitted to our institution for pressure ulcer (PU) treatment. All patients underwent PU surgery with good results. All patients reported a subjective good evacuation setting. No one assumed laxative therapies at home. At admission, all patients underwent abdominal radiography that showed an important constipation, with cases of sub-occlusion or complete occlusion with gastroparesis. One person presented a parastomal, strangulated hernia and underwent hernia reduction and patch positioning around the stoma. During hospital stay, bowel management required an important administration of laxatives and frequent, almost daily, stoma washes.

Discussion: Some considerations must be made regarding the use of traditional techniques in SCI/D people, such as Hartmann's, leaving a large part of the colon and the anatomical position of the stoma itself represent limitations to fecal progression and may cause constipation. A specific approach, tailored on the SCI/D patients' characteristics, such as the one described by our group, should be considered. Even if colostomy has been performed, appropriate therapies and health education on how to manage the stoma are fundamental to prevent complications.

导言:神经源性肠功能障碍是脊髓损伤/疾病(SCI/D)的常见后果。当保守治疗无效时,就会考虑进行结肠造口术[1, 2]。在过去的一年中,我们观察到数名接受结肠造口术的 SCI/D 患者因多种并发症入院:我们介绍了四例接受哈特曼手术治疗的 SCI/D 患者,他们因压迫性溃疡(PU)入院接受治疗。所有患者均接受了压疮手术,效果良好。所有患者均报告主观排便情况良好。没有人在家中使用泻药治疗。入院时,所有患者都接受了腹部X光检查,结果显示存在严重的便秘,其中一些患者出现了亚闭塞或完全闭塞,并伴有胃瘫。其中一人出现了胃旁绞窄性疝气,接受了疝气缩小术,并在造口周围进行了补片定位。住院期间,肠道管理需要大量使用泻药,并几乎每天都要频繁清洗造口:讨论:在对 SCI/D 患者使用传统技术(如哈特曼技术)时必须考虑一些因素,因为结肠的大部分留置和造口本身的解剖位置限制了粪便的排出,并可能导致便秘。应考虑根据 SCI/D 患者的特点采取特定的方法,如我们小组所描述的方法。即使已经实施了结肠造口术,适当的治疗方法和如何管理造口的健康教育也是预防并发症的基础。
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引用次数: 0
The Babinski Sign in 'Perseus with the head of Medusa': revisiting art through a neurological lens. 拿着美杜莎头颅的珀尔修斯》中的巴宾斯基手势:从神经学角度重新审视艺术。
IF 0.7 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-11 DOI: 10.1038/s41394-024-00661-2
Rahul Sachdeva, Lauren Rietchel, Megan Lee, Dmitri Krassioukov-Enns, John Ditunno, Andrei V Krassioukov
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引用次数: 0
Spinal cord lesion MRI and behavioral outcomes in a miniature pig model of spinal cord injury: exploring preclinical potential through an ad hoc comparison with human SCI. 微型猪脊髓损伤模型的脊髓损伤核磁共振成像和行为结果:通过与人类脊髓损伤的特别比较探索临床前潜力。
IF 0.7 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-08 DOI: 10.1038/s41394-024-00658-x
Andrew C Smith, Rakib Uddin Ahmed, Kenneth A Weber, MohammadJavad Negahdar, Destiny Gibson, Maxwell Boakye, Enrico Rejc

Study design: prospective case series of Yucatan miniature pig spinal cord contusion injury model with comparison to human cases of spinal cord injury (SCI).

Objectives: to describe magnetic resonance imaging (MRI) measures of spinal cord lesion severity along with estimates of lateral corticospinal tracts spared neural tissue in both a less severe and more severe contusion SCI model, as well as to describe their corresponding behavioral outcome changes.

Setting: University laboratory setting.

Methods: Following a more severe and less severe SCI, each pig underwent spinal cord MRI to measure lesion characteristics, along with locomotor and urodynamics outcomes testing.

Results: In the pig with more severe SCI, locomotor and urodynamic outcomes were poor, and both the spinal cord lesion volume and damage estimates to the lateral corticospinal tracts were large. Conversely, in the pig with less severe SCI, locomotor and urodynamic outcomes were favorable, with the spinal cord lesion volume and damage estimates to the lateral corticospinal tracts being less pronounced. For two human cases matched on estimates of damage to the lateral corticospinal tract regions, the clinical presentations were similar to the pig outcomes, with more limited mobility and more limited bladder functional independence in the more severe case.

Conclusions: Our initial findings contribute valuable insights to the emergent field of MRI-based evaluation of spinal cord lesions in pig models, offering a promising avenue for understanding and potentially improving outcomes in spinal cord injuries.

研究设计:尤卡坦微型猪脊髓挫伤模型的前瞻性病例系列,并与人类脊髓损伤(SCI)病例进行比较。研究目的:描述脊髓损伤严重程度的磁共振成像(MRI)测量值,以及较轻和较重脊髓挫伤 SCI 模型的侧皮质脊髓束幸免神经组织的估计值,并描述其相应的行为结果变化:环境:大学实验室:方法:在较严重和较不严重的脊髓损伤后,每头猪都接受脊髓核磁共振成像以测量病变特征,同时进行运动学和尿动力学结果测试:结果:在脊髓损伤较严重的猪中,运动和尿动力学结果很差,脊髓病变体积和外侧皮质脊髓束的损伤估计值都很大。相反,在损伤程度较轻的猪中,运动和尿动力学结果良好,脊髓损伤体积和外侧皮质脊髓束的损伤估计值较小。对于两个根据外侧皮质脊髓束区域损伤估计值匹配的人类病例,其临床表现与猪的结果相似,其中较严重病例的活动能力更受限制,膀胱功能独立性也更受限制:我们的初步研究结果为基于核磁共振成像评估猪模型脊髓病变这一新兴领域提供了有价值的见解,为了解脊髓损伤并改善其预后提供了一条前景广阔的途径。
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引用次数: 0
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Spinal Cord Series and Cases
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