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Structure, derivatisation, and metal complexation of p-cyclohexylcalix[4]arene 对环己基杯[4]芳烃的结构、衍生化和金属络合
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-06-03 DOI: 10.1080/10610278.2021.1959920
Chao Shen, Rene Z. H. Phe, Isabella Fong, A. Sobolev, M. Mocerino, Massimiliano Massi, M. Ogden
ABSTRACT Driven by an interest in the impact of the para-substituent of calix[4]arenes on metal complexation and structural chemistry, studies of p-cyclohexylcalix[4]arene (L) have been carried out. The 1:1 dichloromethane and dimethylformamide solvates were found to be isostructural, and different to the typical bilayer structure often observed for p-t-butylcalix[4]arene solvates. The methanol solvate, in contrast, does form a bilayered structure but is also a 1:1 solvate, unlike the p-t-butylcalix[4]arene·2MeOH system. Lanthanoid complexation was investigated, resulting in the structural characterisation of two different DMF solvates of a 2:2 dimeric europium complex, Eu2(L–3H)2(DMF)4. A tetrazole derivative, 5,11,17,23-tetracyclohexyl-25,27-dihydroxy-26,28-bis(tetrazole-5-ylmethoxy)calix[4]arene, has been synthesised via the intermediate 5,11,17,23-tetracyclohexyl-25,27-dihydroxy-26,28-dicyanomethoxycalix[4]arene, with the latter compound being structurally characterised. Attempts to isolate lanthanoid clusters supported by the tetrazole derivative under conditions known to form Ln19 clusters with the p-t-butyl analogue were unsuccessful, resulting only in isolation of the ligand from the reaction mixture. Graphical abstract
由于对杯[4]芳烃对金属络合和结构化学的影响感兴趣,对环己基杯[4]芳烃(L)进行了研究。1:1的二氯甲烷和二甲基甲酰胺溶剂化物是同结构的,不同于对叔丁基杯[4]芳烃溶剂化物的典型双层结构。相反,甲醇溶剂化物确实形成了双层结构,但也是1:1的溶剂化物,这与对叔丁基杯[4]芳烃·2MeOH体系不同。研究了类镧络合作用,得到了2:2二聚体铕络合物Eu2(L-3H)2(DMF)4的两种DMF溶剂化物的结构表征。以中间体5,11,17,23-四环己基-25,27-二羟基-26,28-双(四唑-5-基甲氧基)杯[4]芳烃为原料合成了一种四唑衍生物5,11,17,23-四环己基-25,27-二羟基-26,28-二氰甲氧基杯[4]芳烃,并对后者进行了结构表征。在已知与对丁基类似物形成Ln19簇的条件下,试图分离由四唑衍生物支持的类镧簇是不成功的,只导致从反应混合物中分离出配体。图形抽象
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引用次数: 0
Dual Binding Modes of a Small Cavitand 小腔体的双结合模式
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-06-03 DOI: 10.1080/10610278.2021.1987433
Hannah R. Aziz, Wei Yao, Jacobs H. Jordan, B. Gibb
ABSTRACT The small size and high cohesiveness of water means that water-mediated interactions are strongly context dependent.As a result, there is still much to learn about how non-polar solutes and ions interact with themselves or each other.To help address this issue, we report here on a cavitand host, TMAX-Cl (2). Possessing two different binding sites, a shallow non-polar dish that binds hydrophobes, and a crown of ammoniums that bind anions, TMAX-Cl (2) provides insight into the hydrophobic and Hofmeister effects.We find that binding to the non-polar site is weak, suggesting that a larger surface area is needed for substantial binding.In contrast, binding to the crown of ammoniums is relatively strong, despite the high dielectric of water.These findings provide a better understanding of water-mediated interactions, and define the supramolecular properties of TMAX-Cl 2 as we continue our studies of this host and related water-soluble cavitands. Graphical Abstract
水的小尺寸和高凝聚力意味着水介导的相互作用强烈依赖于环境。因此,关于非极性溶质和离子如何与自身或彼此相互作用,还有很多东西需要学习。为了帮助解决这个问题,我们在这里报道了一个空腔和宿主,TMAX-Cl(2)。TMAX-Cl(2)具有两个不同的结合位点,一个结合疏水分子的浅非极性盘子,和一个结合阴离子的铵冠,TMAX-Cl(2)提供了对疏水和霍夫迈斯特效应的深入了解。我们发现与非极性位点的结合很弱,这表明需要更大的表面积才能进行实质性的结合。相比之下,尽管水的介电性很高,但与氨的结合力相对较强。这些发现提供了对水介导的相互作用的更好理解,并为我们继续研究这种宿主和相关的水溶性空腔体提供了定义TMAX-Cl 2的超分子性质。图形抽象
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引用次数: 1
Selective recognition of bisphenol S isomers in water by β-cyclodextrin β-环糊精对水中双酚S异构体的选择性识别
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-06-03 DOI: 10.1080/10610278.2021.1991925
Ilaria Quaratesi, Paolo Della Sala, Clotilde Capacchione, Carmen Talotta, S. Geremia, N. Hickey, Rocco Gliubizzi, Immacolata Bruno, C. Sgarlata, R. Migliore, C. Gaeta, P. Neri
ABSTRACT The two isomers 4,4´-dihydroxydiphenyl sulphone and 2,4´-dihydroxydiphenyl sulphone (bisphenol S, BPS) form inclusion complexes with β-CD in solution, in the gas phase, and in the solid state. The complexes 4,4´-BPS@β-CD and 2,4´-BPS@β-CD were studied in solution by 1D and 2D NMR experiments. Calorimetric investigation by ITC evidenced that the β-CD host shows a greater affinity for 4,4´-BPS, with a 4,4´-BPS/2,4´-BPS selectivity ratio of 6.3. In the gas phase, CID MS experiments indicate that 4,4´-BPS has a higher kinetic barrier to escape from the β-CD cavity than the isomeric 2,4´-BPS. In the solid state, the 4,4´-BPS@β-CD and 2,4´-BPS@β-CD complexes form head-to-head dimers constituted by two β-CD macrocycles, with each β-CD hosting one BPS guest. The dimers of β-CD are sealed by H-bonding interactions involving exclusively the secondary OH groups. Finally, the formation of inclusion complexes between 4,4´-BPS or 2,4´-BPS and β-CD was also followed by FT-IR, DSC, and TGA analysis. Graphical abstract
摘要:4,4′-二羟基二苯基砜和2,4′-二羟基二苯基砜(双酚S, BPS)两种异构体在溶液、气相和固态下均与β-CD形成包合物。通过一维和二维核磁共振实验研究了配合物4,4′-BPS@β-CD和2,4′-BPS@β-CD。ITC的量热研究表明,β-CD宿主对4,4′-BPS具有更强的亲和力,其4,4′-BPS/2,4′-BPS的选择性比为6.3。在气相中,CID MS实验表明,4,4′-BPS比同分异构体2,4′-BPS具有更高的逃离β-CD腔的动力学屏障。在固体状态下,4,4′-BPS@β-CD和2,4′-BPS@β-CD配合物形成由两个β-CD大环组成的头对头二聚体,每个β-CD含有一个BPS客体。β-CD的二聚体是通过氢键相互作用封闭的,氢键相互作用只涉及仲羟基。最后,对4,4′-BPS或2,4′-BPS与β-CD之间的包合物形成进行FT-IR、DSC和TGA分析。图形抽象
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引用次数: 1
Host-aided intermolecular proton transfer in the inclusion complexes of imidazole ⊂ p-sulfonatocalix[4]arene 咪唑包合物中宿主辅助的分子间质子转移;对磺托环[4]芳烃
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-06-03 DOI: 10.1080/10610278.2021.1990291
I. Ling, Alexandre N. Sobolev
ABSTRACT Structural analysis of two multi-component complexes comprising p-sulfonatocalix[4]arene penta-anion as the host molecule and 1-methylimidazolium or 1-butylimidazolium monocation as the guest species, aquated gadolinium(III) ion along with tetraphenylphosphonium cation, is reported. An interesting process during the formation of these inclusion complexes was seen, in which a proton transfer from p-sulfonatocalix[4]arene to the neutral guest molecules took place via acid-base reaction. 1H NMR experiment confirms the formation of the host–guest complexes and the proton transfer between the calixarene and imidazolium species in solution. Careful analysis aided by CrystalExplorer, the dominant intermolecular interactions that contribute to the stabilisation of the host–guest complex formation were readily identified. Bilayer arrangement prevails in the extended structure for both complexes regardless of the type of guest species. Graphical Abstract
摘要:本文报道了以对磺酰基羧基芳烃五阴离子为宿主分子,以1-甲基咪唑或1-丁基咪唑单位为客体,水化钆(III)离子和四苯基磷离子为络合物的结构分析。在这些包合物的形成过程中,发现了一个有趣的过程,其中质子通过酸碱反应从对磺酰基[4]芳烃转移到中性客体分子。1H NMR实验证实了溶液中杯芳烃与咪唑类化合物之间的质子转移和主客体配合物的形成。在CrystalExplorer的辅助下进行仔细分析,很容易识别出有助于主-客体复合物形成稳定的主要分子间相互作用。无论客体物质的类型如何,两种复合物的扩展结构中普遍存在双层排列。图形抽象
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引用次数: 0
A comparative study between acridine-based macrocycle chemosensor switches to Cd(II): synthesis, spectroscopy, and theoretical calculation 吖啶基大环化学传感器切换到Cd(II)的比较研究:合成、光谱和理论计算
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-06-03 DOI: 10.1080/10610278.2021.1999451
Fabiane dos Santos Carlos, C. Zanlorenzi, Fábio Souza Nunes
ABSTRACT The absorption and emission properties of three acridine-based macrocycles MAC, DAC, and TAC that contain one, two, and four fluorophore units per molecule, respectively, were interpreted and discussed based on DFT and TD-DFT calculations, molecular size, and flexibility. The molecules were tested as fluorosensors for the detection of Cd2+ ions in organic media. GRAPHICAL ABSTARCT
摘要基于DFT和TD-DFT计算、分子大小和灵活性,对三种吖啶基大环(MAC、DAC和TAC)的吸收和发射特性进行了解释和讨论。这些分子被用作有机介质中Cd2+离子检测的荧光传感器。图形ABSTARCT
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引用次数: 1
Introverted Brønsted acid cavitands for selective conjugate addition reactions 用于选择性共轭加成反应的内向Brønsted酸性空腔体
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-06-03 DOI: 10.1080/10610278.2021.1981323
Y. Matsumoto, Y. Taguchi, Naruhiro Yoshida, Shugo Tokai, T. Maruyama, T. Iwasawa
ABSTRACT Four new quinoxaline-spanned cavitands having a diester hydrogen phosphate group were successfully synthesised. These phosphorous derivatives were applied in Brønsted acid-assisted catalytic conjugate addition reactions. The results were ranked with the control of diphenyl hydrogen phosphate as well as among those four cavitands. The structure–activity relationship revealed that the catalyst centre surrounded by two trans-positioned quinoxalines significantly influences reaction profile and product distribution. This comparative study provides us an intellectual basis for future catalytic cavitand chemistry and artificial enzymatic catalysis.
摘要:成功合成了四个新的具有磷酸氢二酯基团的喹诺啉跨空腔体。这些磷衍生物应用于Brønsted酸辅助催化共轭加成反应。结果与磷酸二苯氢对照及上述四种空腔体并列。构效关系表明,催化剂中心被两个错位的喹诺啉所包围,对反应谱和产物分布有显著影响。这一比较研究为今后的催化空腔化学和人工酶催化提供了理论基础。
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引用次数: 1
The construction of gold hybrid supramolecular hydrogels for doxorubicin delivery 阿霉素载药金杂化超分子水凝胶的构建
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-04 DOI: 10.1080/10610278.2021.1973002
Yong Wang, Weixia Qing
ABSTRACT Currently, drug delivery systems with low toxicity and high efficacy are urgently needed to suppress cancer cells. Herein, a non-toxic and biocompatible drug carrier (mPEG-luteolin-AuNPs) was prepared, which was characteristic by SEM, FT-IR, XRD, average particle size, zeta potential and UV-Vis spectra, respectively. Considering that the morphology of supramolecular hydrogel was porous which was good for storage of drugs, a stable supramolecular hydrogel self-assembly formed based on mPEG-luteolin-AuNPs and α-cyclodextrin (α-CD) was reported. Then, supramolecular hydrogel loaded doxorubicin hydrochloride (DOX) and sustained DOX release. Meanwhile, in vitro experiments clearly demonstrated that DOX of hydrogel (mPEG-luteolin-AuNPs/DOX) was biologically active, similar to free DOX, but with better cytotoxicity to human glioblastoma cells (U-87 MG) because of its controllable release. Our findings indicated that mPEG-luteolin-AuNPs/DOX might be promising delivery systems for anticancer chemotherapy. GRAPHICAL ABSTRACT
目前,迫切需要低毒高效的药物传递系统来抑制癌细胞。本文制备了一种无毒且具有生物相容性的药物载体(mpeg -木犀草素- aunps),并通过SEM、FT-IR、XRD、平均粒径、zeta电位和UV-Vis光谱对其进行了表征。考虑到超分子水凝胶具有多孔性,有利于药物的储存,本文报道了一种由mpeg -木犀草素- aunps和α-环糊精(α-CD)组成的稳定的超分子水凝胶自组装体。然后,超分子水凝胶负载盐酸阿霉素(DOX)并持续释放。同时,体外实验清楚地表明,水凝胶DOX (mpeg -木黄素- aunps /DOX)具有生物活性,与游离DOX相似,但由于其释放可控,对人胶质母细胞瘤细胞(U-87 MG)具有更好的细胞毒性。我们的研究结果表明,mpeg -木犀草素- aunps /DOX可能是抗癌化疗的有希望的递送系统。图形抽象
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引用次数: 0
Thiophene-benzothiadiazole based donor–acceptor–donor (D-A-D) bolaamphiphiles, self-assembly and photophysical properties 噻吩-苯并噻唑基给体-受体-给体(D-A-D)亲水分子、自组装和光物理性质
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-04 DOI: 10.1080/10610278.2021.1959036
Qing Chang, Tao Ma, W. Ding, Lin Zhang, Xiaohong Cheng
ABSTRACT Bolaamphiphilies with D-A-D type π-conjugated rigid cores composed by thiophenes as donors (D) and benzothiadiazole (BTD) as central acceptor (A) have been synthesised. Their self-assemblies and photophysical properties were investigated by polarising optical microscope, differential scanning calorimetry, X-ray diffraction and scanning electron microscopy. Such compounds can self-assemble into honeycomb cylinder mesophases with Colhex∆/p6mm and Colsqu/p4mm lattices in their pure states as well as organogels with different morphologies in organic solvents. Their absorption spectra cover nearly the entire visible light range and their band gaps are relatively low. Tetrathiophene BTD based bolaamphilphiles (BT4/n ) with higher D/A ratios than the bisthiophene BTD bolaamphilphiles (BT2/n ) can self-assemble into more ordered nanostructures in both bulk states and solution. Both the absorption and emission peaks of BT4/n are strongly red shifted. The influence of the molecular conformation, the conjugated core length, as well as the D/A ratio on the self-assemble and photophysical characteristics of such D-A-D bolaamphiphiles are discussed. GRAPHICAL ABSTRACT
合成了以噻吩为给体(D)、苯并噻唑(BTD)为中心受体(A)组成的D-A-D型π共轭刚性核的亲bolaamphi亲性化合物。利用偏光显微镜、差示扫描量热法、x射线衍射和扫描电镜对其自组装和光物理性质进行了研究。这些化合物可以在纯态下自组装成具有Colhex∆/p6mm和Colhex /p4mm晶格的蜂窝状圆筒中间相,也可以在有机溶剂中自组装成不同形态的有机凝胶。它们的吸收光谱几乎覆盖了整个可见光范围,并且它们的带隙相对较低。基于四噻吩BTD的亲水分子(BT4/n)比基于双噻吩BTD的亲水分子(BT2/n)具有更高的D/A比,可以在体态和溶液中自组装成更有序的纳米结构。BT4/n的吸收峰和发射峰都发生了强烈的红移。讨论了分子构象、共轭核长度和D/A比值对D-A-D亲水分子自组装和光物理特性的影响。图形抽象
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引用次数: 3
Synthesis, photophysical and assembly studies of novel luminescent lanthanide(III) complexes of 1,2,3-triazolyl-pyridine-2,6-dicarboxamide-based ligands 基于1,2,3-三唑吡啶-2,6-二羧基酰胺的新型发光镧系配合物的合成、光物理和组装研究
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-04 DOI: 10.1080/10610278.2021.1955120
Alex T. O’Neil, Ningjin Zhang, J. A. Harrison, S. Goldup, Jonathan A. Kitchen
ABSTRACT The well-known lanthanide-binding motif, 2,6-pyridinedicarboxamide, has been functionalised with peripheral substituents using copper-catalysed azide alkyne coupling (CuAAC) to develop new symmetrical ‘clicked’ N2,N6-bis((1-(X)-1H-1,2,3,-triazol-4-yl)methyl)pyridine- 2,6-dicarboxamide (where X = ethyl (1) benzyl (2) and 2-naphthyl (3)). These ligands have been successfully coordinated with trivalent lanthanide ions (europium, terbium, and lanthanum) forming [Ln(L)3](CF3SO3)3 complexes. The ligands act as effective antennae for Eu3+ and Tb3+ complexes, which exhibit the characteristic sensitised emission profiles. The ability of 1–3 to assemble into 1:3 M:L systems in solution was investigated using UV-Vis, fluorescence, and NMR. Finally, density functional calculations of the ground state La3+ complexes have been carried out and show similar geometry and coordination parameters to those with available crystallographic data. The facile and modular synthesis of these ‘clicked’ PDC-based ligands makes these compounds excellent candidates for luminescent supramolecular materials development.
众所周知的镧系元素结合基序2,6-吡啶二羧基酰胺(2,6-pyridinedicarboxamide)被铜催化叠氮烷偶联(CuAAC)与外围取代基功能化,得到了新的对称“点击”N2, n6 -双((1-(X)- 1h -1,2,3,-三唑-4-基)甲基)吡啶- 2,6-二羧基酰胺(其中X =乙基(1)苄基(2)和2-萘基(3))。这些配体已成功地与三价镧系离子(铕、铽和镧)配位形成[Ln(L)3](CF3SO3)3配合物。这些配体作为Eu3+和Tb3+配合物的有效天线,表现出特有的敏化发射谱。利用UV-Vis,荧光和NMR研究了1-3在溶液中组装成1:3 M:L体系的能力。最后,对基态La3+配合物进行了密度泛函计算,得到了与已有晶体学数据相似的几何和配位参数。这些“点击”pdc基配体的简单和模块化合成使这些化合物成为发光超分子材料开发的优秀候选者。
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引用次数: 5
Synthesis of novel fused acenaphtopyrimidine hybrid, its photophysical properties and HSA interaction 新型融合苊酰基嘧啶杂化物的合成及其光物理性质和HSA相互作用
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-04 DOI: 10.1080/10610278.2021.1975710
Ergin Yalçın
ABSTRACT A facile and versatile procedure for the synthesis of novel functionalised 10-(1H-indol-3-yl)acenaphtho[1,2-d]pyrimidin-8-amine (compound 4) has been described. The novel intermediate enone (3) and pyrimidine derivatives (4) were characterised by using FT-IR, NMR and MS. Moreover, the photophysical properties of compound 4 and its interaction with HSA (Human Serum Albumin) have been investigated by means of photometric and fluorimetric titration. Compound 4 showed the increase in fluorescence and hypsochromic shift of its maximum upon the addition of HSA that interaction is supported by molecular docking. Overall, Compound 4 has promising affinity towards HSA which was not previously reported for any fused acenaphtenone–pyrimidine hybrid analogues. Graphical abstract
摘要描述了一种简便、通用的合成新型功能化10-(1h -吲哚-3-基)苊[1,2-d]嘧啶-8-胺(化合物4)的方法。利用红外光谱、核磁共振和质谱对化合物3和嘧啶衍生物4进行了表征,并用光度和荧光滴定法研究了化合物4的光物理性质及其与人血清白蛋白的相互作用。化合物4在加入HSA后表现出荧光增强和最大次色移,这种相互作用是由分子对接支持的。总的来说,化合物4对HSA具有很好的亲和力,这在以前的任何融合阿那芬酮-嘧啶杂化类似物中都没有报道。图形抽象
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引用次数: 0
期刊
Supramolecular Chemistry
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