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Amide-Linked Dendron-based Amphiphiles: A class of pH sensitive and highly biocompatible drug carrier for sustained drug release 酰胺链树突类两亲分子:一类pH敏感且具有高度生物相容性的药物缓释载体
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-04 DOI: 10.1080/10610278.2021.1975280
Ashwani Kumar, M. Singh, A. Panda, Y. Tyagi
ABSTRACT PG-dendritic amide-linked amphiphilic micelles were studied to increase the solubility of hydrophobic molecules. The encapsulation study was done by utilising hydrophobic pyrene dye using U.V. technique. The encapsulation efficiency of the non-ionic amphiphiles was obtained at neutral p.H. and at room temperature (p.H. 7.0 & 28 °C). The G.3 dendron-based non-ionic oleic (C18-cis)-amphiphile was found to have the 78.2% encapsulation efficiency. Studies show that the amide-linked G.1 dendron-based non-ionic (C18-cis) amphiphiles have sustained dye release percentage of 78.00% at p.H. 6.2 and 26.19% at p.H. 7.0 in 72 h at 37 °C. The in vitro cyto-toxicological studies showed that after 24–48 h treatment, the G.1 amide amphiphiles exhibit more than 80% of cell viability for concentration as high as 31.25 μg/mL. The cellular uptake was demonstrated using Coumarin 6. The integrated amphiphiles are biocompatible and can be used in the biomedical field as medication encapsulation and target drug delivery. Graphical abstract
研究了聚乙二醇-枝状酰胺连接的两亲性胶束,以提高疏水分子的溶解度。采用紫外技术对疏水性芘染料进行包封研究。在中性ph和室温(ph 7.0和28°C)下获得了非离子两亲体的包封效率。G.3树突基非离子型油酸(C18-cis)两亲体包封率为78.2%。研究表明,在37℃下,酰胺连接的G.1树突基非离子(c18 -顺式)两亲体在ph . 6.2和ph . 7.0条件下,72 h的染料释放率分别为78.00%和26.19%。体外细胞毒理学研究表明,在浓度高达31.25 μg/mL的条件下,G.1酰胺两亲体在处理24 ~ 48 h后,细胞存活率可达80%以上。用香豆素6证明了细胞摄取。该两亲体具有生物相容性,可用于生物医学领域的药物包封和靶向给药。图形抽象
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引用次数: 0
The conglomerate crystal formation of methoxetamine salts in the presence of some organic achiral anions: a theoretical approach 甲氧基胺盐在一些有机非手性阴离子存在下的砾岩晶体形成:一种理论方法
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-04 DOI: 10.1080/10610278.2021.1961259
Nabi Javadi, Mojtaba Rezaeian, H. Fakhraian
ABSTRACT Density functional theory (DFT) calculations were made to investigate the interaction between enantiomers of methoxetamine (R & S) and achiral organic reagents, such as oxalate, succinate, fumarate, maleate, glutarate, adipate, pimelate, and suberate anions. The obtained results indicate that the oxalate and maleate anions have a greater ability to form conglomerate crystal of methoxetamine in the gas phase and in solution with chloroform, ethanol, and water. Results of the energy analysis reveal that, in comparison to gas phase and chloroform, the Gibbs energy, enthalpy, and internal thermal energy become more positive in the presence of water and ethanol solvents, confirming the negative effect of solvent polarity on enantiomer separation. It should also be noted that the presence of carbon-chain lengths greater than 3 atoms in organic reagents is not suitable for enantiomer separation and conglomerate crystal formation. . Graphical abstract
采用密度泛函理论(DFT)研究了甲氧基胺对映体(R & S)与草酸盐、琥珀酸盐、富马酸盐、马来酸盐、戊二酸盐、己二酸盐、戊酸盐和亚酸盐等非手性有机试剂的相互作用。结果表明,草酸盐和马来酸盐阴离子在气相和氯仿、乙醇和水的溶液中形成甲氧基乙胺团状晶体的能力更强。能量分析结果表明,与气相和氯仿相比,在水和乙醇溶剂存在下,吉布斯能、焓和内热能变得更正,证实了溶剂极性对对映体分离的负面影响。还应注意的是,有机试剂中存在长度大于3个原子的碳链,不利于对映体的分离和砾岩晶体的形成。图形抽象
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引用次数: 0
Syntheses and aggregation properties of new squalene receptors bearing open chain ligands 新型开链配体角鲨烯受体的合成及聚集性质
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-04 DOI: 10.1080/10610278.2021.1970161
Tran Ngoc Linh, T. Arimura, Kenichi Tominaga, H. Kigoshi, H. Isoda
ABSTRACT New squalene receptors bearing open-chain polyether ligands (SQ-diEG, SQ-triEG, SQ-tetraEG) were synthesised. The stoichiometries and association constants ( K a) for the interactions between these squalene receptors and representative alkaline earth metal ions (Mg2+, Ca2+, and Ba2+) were determined in solution. Fluorescence spectral studies revealed that the squalene receptors self-associate with critical vesicle concentrations at 25 °C of 2.2 × 10−5 M for SQ-diEG, 2.3 × 10−5 M for SQ-triEG, and 2.5 × 10−5 M for SQ-tetraEG. The self-assembly behaviour was probed using laser diffraction particle size-based analyses and scanning electron microscopy. A decrease in the SQ-tetraEG vesicle size was readily induced by the addition of alkaline earth metal ions, confirmed by cryogenic transmission electron microscopy. Graphical abstract
摘要合成了新型开链聚醚配体角鲨烯受体(SQ-diEG、SQ-triEG、SQ-tetraEG)。测定了这些角鲨烯受体与代表性碱土金属离子(Mg2+、Ca2+和Ba2+)相互作用的化学计量学和缔合常数(K a)。荧光光谱研究表明,角鲨烯受体与25°C时的临界囊泡浓度(SQ-diEG为2.2 × 10−5 M, SQ-triEG为2.3 × 10−5 M, SQ-tetraEG为2.5 × 10−5 M)自相关。利用激光衍射粒度分析和扫描电镜对其自组装行为进行了研究。低温透射电镜证实,加入碱土金属离子后,SQ-tetraEG囊泡大小明显减小。图形抽象
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引用次数: 1
A colorimetric and fluorescence sensor based on biphenolic-dansyl derivative for specific fluoride ion detection 一种基于双酚丹酰衍生物的氟离子特异性检测比色和荧光传感器
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-04 DOI: 10.1080/10610278.2021.1950720
Sitthichok Mongkholkaew, A. Songsasen, W. Sirisaksoontorn, B. Wannalerse
ABSTRACT 2ʹ-(2-((4-(methylthio)phenyl)amino)-2-oxoethoxy)-[1,1ʹ-biphenyl]-2-yl 5(dimethyl amino)naphthalene-1-sulphonate (1) was synthesised and used as a F− ion sensor. The selectivity of sensor 1 with various anions (F−, Cl−, Br−, CH3COO−, C6H5COO− and H2PO4 −) in DMSO was evaluated by 1H NMR, UV-visible and fluorescence study. For 1H NMR, an amide proton of sensor 1 disappeared due to the deprotonation reaction upon addition of F− ion. On the contrary, the proton signal of HF2 − emerged at 16.11 ppm. Upon addition of F− ion, sensor 1 showed a new absorption band at 300 nm and the solution turned colourless. For fluorescence response, sensor 1 exhibited the enhancement of emission intensity at 434 nm with slight blue shift when titrated with F− ion. These results suggest that sensor 1 possessed high sensitivity and selectivity towards F− ion detection. In addition, the sensor 1 test strip coated on TLC plates and filter papers were demonstrated for specific detection F− ion. Graphical abstract
摘要合成了2′-(2-(4-(甲基硫)苯基)氨基)-2-氧乙氧基)-[1,1′-联苯]-2-基5(二甲基氨基)萘-1-磺酸盐(1),并将其用作F -离子传感器。通过1H NMR、紫外可见和荧光研究,评价了传感器1对不同阴离子(F−、Cl−、Br−、CH3COO−、C6H5COO−和H2PO4−)在DMSO中的选择性。在1H NMR中,传感器1的一个酰胺质子在加入F−离子后发生去质子化反应而消失。相反,HF2−的质子信号在16.11 ppm时出现。加入F−离子后,传感器1在300 nm处显示出新的吸收带,溶液变为无色。在荧光响应方面,传感器1在434 nm处的发射强度增强,并伴有轻微的蓝移。这些结果表明,传感器1对氟离子检测具有较高的灵敏度和选择性。此外,还演示了涂覆在TLC板和滤纸上的传感器1测试条对F−离子的特异性检测。图形抽象
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引用次数: 1
Synthesis of quinoxaline cavitand baskets 喹啉空腔和筐的合成
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-04-03 DOI: 10.1080/10610278.2021.1917768
Alessia Favero, A. Rozzi, C. Massera, A. Pedrini, R. Pinalli, E. Dalcanale
ABSTRACT The unique temperature, solvent and pH drivenvase to kite equilibrium in quinoxaline cavitands allows the reversible uptake and release of guests. However, the cavity breathing associated with this conformational switch reduces the strength of complexation. A limited number of solutions have been proposed for the cavity rigidification, using either H-bonding, metal coordination or covalent connections. Here we report the synthesis and structural characterisation of quinoxaline-based cavitand baskets, which present two distal quinoxaline walls linked together. Baskets A and B were obtained through a bridging reaction starting from an AC di-quinoxaline bridged cavitand using two different di-quinoxaline moieties. In both cases, two isomers were obtained: isomer C2, with the linking unit crossing the cavity mouth, and isomer Cs, having the linker sideways. The isomers were identified through 1H NMR analysis. In the case of basket A-Cs, the resolved molecular structure confirmed the Cs symmetry of the basket. Grapical abstract
独特的温度,溶剂和pH驱动的花瓶在喹啉空腔体中保持平衡,允许可逆的吸收和释放来访者。然而,与这种构象转换相关的腔呼吸降低了络合的强度。已经提出了有限数量的解决方案的空腔硬化,使用氢键,金属配位或共价连接。在这里,我们报告了基于喹诺啉的空腔和筐的合成和结构表征,其中两个远端喹诺啉壁连接在一起。筐A和筐B是通过桥接反应得到的,桥接反应从AC二喹啉桥接腔开始,并使用两种不同的二喹啉基团。在这两种情况下,得到了两种异构体:异构体C2,连接单元穿过腔口,和异构体Cs,具有横向连接。通过核磁共振氢谱分析对异构体进行了鉴定。在筐A-Cs的情况下,分解的分子结构证实了筐的Cs对称性。Grapical文摘
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引用次数: 1
Carbazole-based bis-ureas and thioureas as electroneutral anion transporters 咔唑基双脲和硫脲作为电中性阴离子转运体
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-04-03 DOI: 10.1080/10610278.2021.1946539
Patrick Wang, Xin Wu, Philip A. Gale
ABSTRACT We report a series of easily accessible carbazole-based bis-ureas and thioureas as effective anion receptors and transporters. The compounds exhibit moderate Cl− binding affinity in wet DMSO and Cl− transport capabilities in phospholipid membranes predominantly through an electroneutral H+/Cl− and anion exchange mechanisms. Graphical abstract
我们报道了一系列容易获得的以咔唑为基础的双脲和硫脲作为有效的阴离子受体和转运体。这些化合物在湿DMSO中表现出适度的Cl -结合亲和力,并主要通过电中性的H+/Cl -和阴离子交换机制在磷脂膜中转运Cl -。图形抽象
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引用次数: 2
Protein-macrocycle framework engineering: supramolecular copolymerisation with two disparate calixarenes 蛋白质-大环框架工程:两种不同杯芳烃的超分子共聚
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-04-03 DOI: 10.1080/10610278.2021.1935946
N. M. Mockler, S. Engilberge, M. Rennie, C. Raston, P. B. Crowley
ABSTRACT Water soluble calixarenes are versatile mediators of protein assembly, including the fabrication of crystalline frameworks. Here, we report the X-ray crystal structure of cytochrome c (cytc) co-crystallised with two different calixarenes: phosphonato-calix[6]arene (pclx6 ) and sulfonato-calix[8]arene (sclx8 ). Each calixarene type acts as an independent molecular glue that mediates cytc dimers within the crystal. The calixarene-mediated dimers combine to yield chains of cytc-sclx8 -cytc-pclx6-pclx6 repeating units. These supramolecular copolymer units pack together, via a protein-protein interface, to yield a porous dendrite-like assembly. Interestingly, the tri-component framework has features in common with previously reported structures of cytc in complex with pclx6 or sclx8 . Known protein-calixarene ‘building blocks’ combine in novel ways to yield the tri-component assembly, highlighting the versatility of calixarene molecular glues in protein crystal engineering. Graphical abstract
水溶性杯芳烃是蛋白质组装的多功能介质,包括晶体框架的制造。本文报道了细胞色素c (cytc)与两种不同杯芳烃共结晶的x射线晶体结构:膦化杯芳烃[6](pclx6)和磺化杯芳烃[8](sclx8)。每个杯芳烃类型作为一个独立的分子胶,调解晶体内的细胞二聚体。杯芳烃介导的二聚体结合生成cytc-sclx8 -cytc-pclx6-pclx6重复单元链。这些超分子共聚物单元通过蛋白质-蛋白质界面聚集在一起,形成多孔的树突状组装体。有趣的是,三组分框架具有与先前报道的与pclx6或sclx8复合物的cytc结构相同的特征。已知的蛋白质-杯芳烃“构建块”以新颖的方式结合产生三组分组装,突出了杯芳烃分子胶在蛋白质晶体工程中的多功能性。图形抽象
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引用次数: 2
Supramolecular interactions in the heteroarylimine-substituted calix[4]arenes: the formation of cyclic dodecanuclear palladium aggregates 杂芳胺取代杯[4]芳烃中的超分子相互作用:环十二核钯聚集体的形成
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-04-03 DOI: 10.1080/10610278.2021.1944632
L. Tsymbal, R. Rodik, O. Danylyuk, K. Suwińska, J. Lipkowski, V. Kalchenko, Y. D. Lampeka
ABSTRACT Two new derivatives of calix[4]arene bearing on the upper rim 2-thiopenyl (Thicalix) or 2-pyridyl (Pycalix) Schiff-base substituents have been synthesised and characterised by IR, NMR, MS, and single crystal X-ray diffraction techniques. It was shown that the interaction of Thicalix with the copper(II) and palladium(II) ions is accompanied by hydrolysis of the azomethine bonds with subsequent oxidation of the aminophenolic fragment to diquinone Diquin, while the reaction of potassium tetrachloropalladate(II) with Pycalix results in the formation of metallocompex with 1:2 calix[4]arene/Pd(II) ratio. The single crystal X-ray diffraction analysis of Thicalix (1), the complex [(PdCl2)2(Pycalix)] (2) and Diquin (3) revealed that all compounds form molecular crystals as a result of numerous supramolecular interactions involving C − H···O, C − H···Cl, and C − H···π contacts. For 1 and 3 such interactions result in formation of dimers, while in 2 the dodecanuclear palladium aggregates composed of six calix[4]arene moieties are formed. Graphical Abstract1
合成了两个新的杯[4]芳烃衍生物,上缘为2-噻吩基(Thicalix)或2-吡啶基(Pycalix)希夫碱取代基,并通过IR、NMR、MS和单晶x射线衍射技术对其进行了表征。结果表明:与铜(II)和钯(II)离子相互作用时,苯胺键被水解,氨基酚片段被氧化为二醌二醌,而四氯丙酸钾(II)与Pycalix反应时,形成了杯[4]芳烃/钯(II)比为1:2的金属配合物。对Thicalix(1)、配合物[(PdCl2)2(pycalx)](2)和Diquin(3)的单晶x射线衍射分析表明,所有化合物都是由C−H··O、C−H··Cl和C−H··π接触等大量超分子相互作用形成分子晶体的。对于1和3,这种相互作用导致形成二聚体,而在2中,形成了由六个杯[4]芳烃组成的十二核钯聚集体。图形摘要
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引用次数: 0
Adsorption of methyl violet from aqueous solution using β-cyclodextrin immobilised onto mesoporous silica 介孔二氧化硅固载β-环糊精吸附水溶液中甲基紫的研究
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-04-03 DOI: 10.1080/10610278.2021.1917574
Kai Liu, Huijun Liu, Liuxing Li, Wei Li, Juan Liu, Ting Tang
ABSTRACT β-cyclodextrin(β-CD) was immobilised onto mesoporous silica using 1,1′-carbonyldiimidazole and tetraethyl orthosilicate as raw materials to construct adsorbent in dye wastewater treatment. The mesoporous structure of β-CD@SiO2-1 was characterised by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), specific surface area measurement (BET), thermogravimetric (TG) and scanning electron microscopy (SEM). The adsorption experiments were studied by response surface method (RSM) to optimise various parameters such as initial concentration, contact time and adsorbent dosage on the adsorption property of β-CD@SiO2-1 to methyl violet. The optimum process conditions were initial concentration 34 mg/L, contact time 13 h and adsorbent dose 5 mg. The adsorption rates correspond to the pseudo-second-order kinetic model. The adsorption isotherm was suited to the Langmuir isotherm model. The thermodynamic parameters (ΔG°, ΔH°, ΔS°) were obtained. As a result, it was found that the adsorption process was exothermic and spontaneous. GRAPHICAL ABSTRACT
以1,1′-羰基二咪唑和正硅酸四乙酯为原料,将β-环糊精(β-CD)固定在介孔二氧化硅上,构建染料废水处理吸附剂。采用傅里叶变换红外光谱(FT-IR)、x射线衍射(XRD)、比表面积(BET)、热重(TG)和扫描电镜(SEM)对β-CD@SiO2-1介孔结构进行了表征。采用响应面法(RSM)研究了初始浓度、接触时间、吸附剂用量等参数对β-CD@SiO2-1对甲基紫吸附性能的影响。最佳工艺条件为初始浓度34 mg/L,接触时间13 h,吸附剂用量5 mg。吸附速率符合准二级动力学模型。吸附等温线符合Langmuir等温线模型。得到了热力学参数ΔG°,ΔH°,ΔS°。结果表明,吸附过程是自发的、放热的。图形抽象
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引用次数: 2
Quantum chemical study on the adsorption of megazol drug on the pristine BC3 nanosheet megazol药物在BC3纳米片上吸附的量子化学研究
IF 3.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-03-04 DOI: 10.1080/10610278.2021.1938049
Peilong Xu, Jiyin Cao, Cheng Yin, Longting Wang, Liang Wu
ABSTRACT In order to assess the electrical response of the BC3 nanosheets to megazol, computations according to the density functional theory (DFT) have been done. Pristine BC3 is determined to have a notable trend towards the megazol molecules. For the most stable configuration, the adsorption energy is approximately −20.7 kcal/mol. Megazol adsorption makes a noticeable decrease in the gap of HOMO (highest occupied molecular orbital) -LUMO (lowest unoccupied molecular orbital) BC3 nanosheets (from 1.45 to 0.75 V), thereby enhancing the electrical conductivity, which means the BC3 can be a proper choice for megazol detection and electronic sensor applications. Additionally, megazol adsorption has affected the work function of BC3, which remarkably shifts the current of field electron emission from its level, suggesting it for detecting megazol as a function-based sensor. Also, BC3 has the benefit of a short recovery time of approximately 7.72 ms for megazol desorption. Graphical Abstract
为了评估BC3纳米片对甲醚的电响应,采用密度泛函理论(DFT)进行了计算。确定了原始BC3具有向甲脲分子的显著趋势。对于最稳定的构型,吸附能约为−20.7 kcal/mol。Megazol吸附使BC3纳米片HOMO(最高已占据分子轨道)-LUMO(最低未占据分子轨道)的间隙明显减小(从1.45 V减小到0.75 V),从而提高了BC3的导电性,这意味着BC3可以作为Megazol检测和电子传感器应用的合适选择。此外,甲基甲醚的吸附影响了BC3的功函数,使其场电子发射电流从其水平显著改变,表明它可以作为一种基于功能的传感器来检测甲基甲醚。此外,BC3对甲脲解吸的恢复时间短,约为7.72 ms。图形抽象
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引用次数: 53
期刊
Supramolecular Chemistry
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