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Targeted Bleeding Management Reduces the Requirements for Blood Component Therapy in Lung Transplant Recipients 靶向出血管理减少了肺移植受者血液成分治疗的需求
Pub Date : 2017-08-01 DOI: 10.1097/01.SA.0000525621.77704.76
I. Smith, B. Pearse, D. Faulke, Rishendran R Naidoo, Lisa Nicotra, P. Hopkins, E. Ryan
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引用次数: 2
Monkey in the Middle: Translational Studies of Pediatric Anesthetic Exposure. 猴子在中间:儿科麻醉暴露的转化研究。
Pub Date : 2017-08-01 DOI: 10.1097/01.sa.0000525615.53047.aa
M. Baxter, M. Alvarado
P reclinical animal studies have resulted in retrospective and prospective studies in humans regarding the safety of pediatric anesthesia. The possibility of adverse neurocognitive outcomes associated with repeated or prolonged pediatric anesthesia is worrisome. The latest investigation by Coleman et al also investigates the impact of exposure to general anesthesia in infancy on neurobehavioral development in nonhuman primates. This is a translationally relevant model as the stage of brain development at birth of a rhesus monkey is similar to that of a 6-month-old human infant. Also, physiologicmonitoring and support are more viable in the case of an infant monkey rather than with an infant rodent. Hence, the study by Coleman et al provides
临床动物研究已经对儿童麻醉的安全性进行了回顾性和前瞻性的人体研究。与反复或延长小儿麻醉相关的不良神经认知结果的可能性令人担忧。Coleman等人的最新研究还调查了婴儿期接受全身麻醉对非人灵长类动物神经行为发育的影响。这是一个与翻译相关的模型,因为恒河猴出生时的大脑发育阶段与6个月大的人类婴儿相似。此外,生理监测和支持在猴子婴儿身上比在啮齿动物婴儿身上更可行。因此,Coleman等人的研究提供
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引用次数: 7
Impact of Focused Intraoperative Transthoracic Echocardiography by Anaesthesiologists on Management in Hemodynamically Unstable High-Risk Noncardiac Surgery Patients 麻醉医师术中经胸超声心动图对血流动力学不稳定高危非心脏手术患者处理的影响
Pub Date : 2017-08-01 DOI: 10.1097/01.sa.0000525647.48445.c1
T. Kratz, T. Steinfeldt, M. Exner, M. C. DellʼOrto, N. Timmesfeld, C. Kratz, M. Skrodzki, H. Wulf, M. Zoremba
Perioperative hemodynamic monitoring and intervention using transthoracic echocardiography (TTE) in highrisk surgery patients can decrease the rates of adverse events, morbidity, and mortality; however, evidence regarding its benefits is required. This prospective interventional study aimed at evaluating the efficacy of intraoperative TTE to alter patient management in high-risk and extensively monitored surgical patients susceptible to hemodynamic instability. The study included 52 hemodynamically unstable high-risk abdominal, vascular, or thoracic surgery patients. Patients were anesthetized, and focused TTE was performed when intraoperative hemodynamic instability occurred (hypotension or low cardiac output for a period of ≥3 minutes). Cardiac output monitoring system using pulse contour analysis was established before induction of anesthesia. The definitive therapy leading to an alteration of management was guided by the results of the focused TTE. Differences between intended and actual therapies and changes in management were documented as the primary end points. The analysis of TTE quality and description of pathophysiologic cardiovascular findings were the secondary end points. Sample size estimation and statistical analyses were performed with the statistical software R (www.r-project.org). Changes of management were noted in 33 patients (66%; 95% confidence interval, 52.11%–77.61%) and 38 hemodynamic situations (46.34%; 95% confidence interval, 35.95%–57.06%) of the 50 hemodynamically unstable patients examined by additional focused TTE. Transthoracic echocardiography identified pathologic findings in 47 patients: hypovolemia (66%), left ventricular dysfunction (8%), right ventricular overload (22%), and right-sided heart failure (4%). Lack of randomization and the absence of a control group were the major limitations of this study.
应用经胸超声心动图(TTE)对高危手术患者进行围手术期血流动力学监测和干预可以降低不良事件发生率、发病率和死亡率;然而,需要证据来证明它的好处。这项前瞻性介入研究旨在评估术中TTE对易发生血流动力学不稳定的高风险和广泛监测的外科患者的治疗效果。该研究包括52例血液动力学不稳定的高危腹部、血管或胸外科患者。患者麻醉后,术中血流动力学不稳定(低血压或低心排血量≥3分钟)时进行集中TTE。建立了麻醉诱导前脉搏轮廓分析的心输出量监测系统。最终的治疗导致管理的改变是由重点TTE的结果指导的。预期治疗和实际治疗之间的差异以及管理的变化被记录为主要终点。TTE质量分析和心血管病理生理表现描述是次要终点。使用统计软件R (www.r-project.org)进行样本量估计和统计分析。33例患者(66%;95%可信区间为52.11% ~ 77.61%)和38种血流动力学情况(46.34%;(95%可信区间,35.95% ~ 57.06%)。经胸超声心动图确定了47例患者的病理表现:低血容量(66%)、左心室功能障碍(8%)、右心室负荷过重(22%)和右侧心力衰竭(4%)。缺乏随机化和缺乏对照组是本研究的主要局限性。
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引用次数: 0
Transthoracic echocardiography and electrical cardiometry elucidate the hemodynamics of autotransfusion during labor under epidural analgesia. 经胸超声心动图和心电测量阐明了硬膜外镇痛下分娩过程中自身输血的血流动力学。
Pub Date : 2017-08-01 DOI: 10.1097/SA.0000000000000334
T. Archer
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引用次数: 5
Vasopressin, Norepinephrine, and Vasodilatory Shock After Cardiac Surgery: Another “VASST” Difference? 血管加压素、去甲肾上腺素和心脏手术后血管扩张性休克:另一个“VASST”差异?
Pub Date : 2017-08-01 DOI: 10.1097/01.sa.0000525623.85327.92
J. Russell
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引用次数: 0
The Effect of Melatonin on Early Postoperative Cognitive Decline in Elderly Patients Undergoing Hip Arthroplasty: A Randomized Controlled Trial 褪黑素对老年髋关节置换术患者术后早期认知能力下降的影响:一项随机对照试验
Pub Date : 2017-08-01 DOI: 10.1097/01.sa.0000525625.70080.7b
Yunxia Fan, Liang-xi Yuan, Muhuo Ji, Jianjun Yang, Da-peng Gao
Copyright © 2017 Wolters Kluwer rate POCD. Exogenous melatonin improves sleep quality in patients with primary sleep disorders and can improve cognitive dysfunction in adults with mild cognitive impairment. This prospective cohort study aimed to determine whether melatonin can ameliorate early POCD in elderly hip arthroplasty patients. The study included 139 American Society of Anesthesiologists grades I to III patients older than 65 years scheduled for hip arthroplasty with spinal anesthesia. Patients were randomized to receive either 1 mg oral melatonin or placebo daily 1 hour before bedtime 1 day before surgery and for another 5 consecutive days postoperatively. Subjective sleep quality, generalwell-being, postoperative fatigue, visual analog scale for pain, and cognitive function (using Mini Mental State Examination [MMSE]) were evaluated preoperatively and at days 1, 3, 5, and 7 postoperatively. Statistical analysis was performed using the SPSS 16.0 software forWindows (SPSS, Chicago, Ill), and P < 0.05 was considered to be statistically significant. The MMSE score in the melatonin group did not change during the 7 days of monitoring after surgery, but in the control group, the MMSE score decreased significantly at days 1, 3, and 5 after surgery when compared with its own preoperative value and with the melatonin group value for the corresponding date (P < 0.05). A significant postoperative impairment of subjective sleep quality (F statistic estimate of variation [F] = 7.95, P < 0.05), general well-being (F = 5.791, P < 0.05), and fatigue (F = 8.333, P > 0.05) was found in the control group when compared with the melatonin group. In conclusion, perioperative melatonin supplementation improved preoperative sleep quality, thus confirming that exogenous melatonin can improve early POCD. Further studies are required to evaluate the effects of comorbidities and medication usage on melatonin's role in improving cognitive dysfunction.
版权所有©2017威科集团费率POCD。外源性褪黑素可改善原发性睡眠障碍患者的睡眠质量,并可改善轻度认知障碍成人的认知功能障碍。这项前瞻性队列研究旨在确定褪黑激素是否可以改善老年髋关节置换术患者的早期POCD。该研究包括139名年龄大于65岁的美国麻醉医师协会分级为I至III级的患者,他们计划接受脊柱麻醉的髋关节置换术。患者在术前1天睡前1小时随机接受1毫克口服褪黑素或安慰剂,术后连续5天。主观睡眠质量、总体幸福感、术后疲劳、疼痛视觉模拟量表和认知功能(使用迷你精神状态检查[MMSE])在术前和术后第1、3、5和7天进行评估。采用SPSS 16.0软件(SPSS, Chicago, Ill)进行统计学分析,P < 0.05为差异有统计学意义。褪黑素组患者术后监测7 d内MMSE评分无变化,而对照组患者术后1、3、5 d MMSE评分与自身术前值及同期褪黑素组比较,均显著降低(P < 0.05)。与褪黑激素组相比,对照组术后主观睡眠质量(F统计方差估计[F] = 7.95, P < 0.05)、总体幸福感(F = 5.791, P < 0.05)和疲劳感(F = 8.333, P > 0.05)均出现显著下降。综上所述,围手术期补充褪黑激素可改善术前睡眠质量,从而证实外源性褪黑激素可改善早期POCD。需要进一步的研究来评估合并症和药物使用对褪黑素改善认知功能障碍的作用的影响。
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引用次数: 0
Paediatric Emergence Delirium: A Comprehensive Review and Interpretation of the Literature 小儿突发性谵妄:文献综述与解读
Pub Date : 2017-08-01 DOI: 10.1097/01.sa.0000525614.45424.ba
K. Mason
This article considers the evolution of emergence delirium (ED) and emergence agitation since it was first identified in the 1960s to assess present and future trends in identification, treatment, and prognostic value. There is a need for well-designed large prospective studies to assess ED risk factors and eliminate confounders as well as a need for standardized screening, evaluation tools, and data sharing in order to easily compare outcomes for researchers of pediatric ED (characterized by crying, sobbing, thrashing about, and disorientation following anesthesia). Emergence delirium should therefore be considered a “vital sign” to be consistently documented in the pediatric postanesthesia recovery period. The Paediatric Anaesthesia Emergence Delirium (PAED) scale, which assigns scores based on exhibited behavior, is used to identify ED currently. Because of problems in assessing normal behavior in children (especially those with special needs) in a stressful clinical environment, a better protocol is needed. A baseline preoperative and postoperative PAEDwould be useful to provide a comparative reference point in the recovery room and reduce the risk of falsepositive results. Routine monitoring and preoperative and postoperative PAED scores treated as vital signs in the pediatric units will yield better ED assessments and care. The best approach to reducing ED should be preventing its occurrence rather than treating the symptoms and pain with α2-adrenergic agonists. Standardized and routine monitoring of ED will ensure better understanding of the risk factors and prevention of this phenomenon leading to better delivery of care to children and faster recovery in the postoperative setting.
本文考虑了自20世纪60年代首次发现出现性谵妄(ED)和出现性躁动以来的演变,以评估当前和未来在识别、治疗和预后价值方面的趋势。需要设计良好的大型前瞻性研究来评估ED的危险因素并消除混杂因素,还需要标准化的筛查、评估工具和数据共享,以便儿科ED(以哭泣、抽泣、抽搐和麻醉后定向障碍为特征)的研究人员容易比较结果。因此,出现性谵妄应被视为在儿童麻醉后恢复期持续记录的“生命体征”。儿科麻醉突发性谵妄(PAED)量表,根据表现出的行为进行评分,目前用于识别ED。由于在紧张的临床环境中评估儿童(特别是有特殊需要的儿童)的正常行为存在问题,因此需要一个更好的方案。术前和术后基线paed将有助于为恢复室提供一个比较参考点,并降低假阳性结果的风险。常规监测和术前、术后PAED评分作为儿科病房的生命体征将产生更好的ED评估和护理。减少ED的最佳方法应该是预防其发生,而不是用α2-肾上腺素能激动剂治疗症状和疼痛。ED的标准化和常规监测将确保更好地了解危险因素和预防这一现象,从而更好地为儿童提供护理,并在术后更快地恢复。
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引用次数: 10
Thoracic Anesthesia Intubated Versus Nonintubated General Anesthesia for Video-Assisted Thoracoscopic Surgery—A Case-Control Study 胸腔插管麻醉与非插管全麻在电视胸腔镜手术中的对比——病例对照研究
Pub Date : 2017-08-01 DOI: 10.1097/01.SA.0000525622.77704.ad
J. Irons, L. Miles, K. Joshi, A. Klein, M. Scarci, P. Solli, G. Martinez
A lthough deemed mandatory to provide safe and optimal operating conditions for surgical manipulation, general anesthesia with endobronchial intubation and 1-lung positive-pressure ventilation for thoracic surgery has been known to cause lung injury. Nonintubated thoracic anesthetic techniques for video-assisted thoracoscopic surgery (VATS) in awake and sedated patients can be an alternate method to decrease the overall invasiveness and surgical stress. A nonintubated general anesthetic technique with airway support via a supraglottic airway device with the patient awake or under sedation was developed. A retrospective observational study was conducted to compare the nonintubated general anesthetic technique to an intubated general anesthesia group for minor VATS procedures.
尽管被认为必须为手术操作提供安全和最佳的操作条件,但已知胸外科手术全麻支气管内插管和单肺正压通气会导致肺损伤。在清醒和镇静的患者中,非插管胸腔镜手术(VATS)技术可以作为减少整体侵入性和手术压力的替代方法。在患者清醒或镇静状态下,通过声门上气道装置进行气道支持的非插管全麻技术。一项回顾性观察性研究进行了比较非插管全麻技术和插管全麻组的小VATS程序。
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引用次数: 0
Context is king - obstetric anaesthesia management strategies in limited resource settings. 背景为王-有限资源环境下的产科麻醉管理策略。
Pub Date : 2017-08-01 DOI: 10.1097/01.sa.0000527498.71626.89
D. Bishop, R. Rodseth, R. A. Dyer
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引用次数: 4
Accuracy and Precision of Non-invasive Cardiac Output Monitoring Devices in Perioperative Medicine: A Systematic Review and Meta-analysis 围手术期医学无创心输出量监测装置的准确性和精密度:一项系统综述和荟萃分析
Pub Date : 2017-08-01 DOI: 10.1097/SA.0000000000000319
A. Joosten, O. Desebbe, K. Suehiro, L. Murphy, M. Essiet, B. Alexander, M. Fischer, L. Barvais, L. Obbergh, D. Maucort-Boulch, M. Cannesson
The main purpose of this article is to provide a systematic review of all medical literature (37 studies; 1543 patients) comparing cardiac output (CO) measured with a commercially available completely noninvasive CO monitoring device against bolus thermodilution (TD) in various clinical settings such as the intensive care unit, emergency department, and the operating room. In addition, the authors provide a meta-analysis of the data extracted from the systematic review to calculate the precision of these noninvasive CO monitoring devices when used perioperatively by following pooled estimates. The authors gathered data from the systematic review in order to calculate the following 4 variables: (1) the pooled estimate of the mean difference between the tested method of bolus TD and the noninvasive reference method (bias), (2) the pooled estimate of the standard deviation (precision) of the bias, (3) the pooled estimate of the 95% confidence intervals of the bias, and (4) the pooled estimate of the percentage of error (PE). An acceptable agreement between the tested and the reference method was defined as a pooled estimate (PE) of 30% or greater. Despite it being crucial in critical care management, CO, the basis of measuring oxygen delivery to end organs, has been demonstrably undermonitored in clinical settings. New noninvasive techniques and older methods abound for monitoring CO including pulse wave transit time (PWTT), noninvasive pulse contour analysis (niPCA), partial CO2 rebreathing (CO2r), and thoracic electrical bioimpedance (TEB), yet the “go-to” in the clinical setting is the traditional invasive technique of bolus TD. Mean CO was 4.78 L/min in both methods. The overall random-effects pooled bias was −0.13 L/min (−2.38 to 2.12 L/min) and PE 47% with high interstudy sensitivity heterogeneity (I = 83%, P < 0.001). Despite the many advances in medical technology since the early 2000s, both TEB and CO2r have not shown significantly increased agreement when compared with bolus TD (PE for TEB was 37% in 1999, 43% in 2010, and 42% in 2016 in this metaanalysis; CO2r PE was similar to 2010: 44.5% against 40% in this meta-analysis). Recent techniques, such as PWTTand the niPCA, have a PE of 62% for PWTT and 45% for niPCA. Completely noninvasive technologies for the measurement of CO did not reach an acceptable level of agreement. The PEs of all noninvasive techniques were above the preset threshold of 30%, and the
本文的主要目的是对所有医学文献(37项研究;1543例患者)比较了在各种临床环境(如重症监护室、急诊科和手术室)使用市售的完全无创CO监测装置测量的心输出量(CO)和大剂量热稀释(TD)。此外,作者对从系统综述中提取的数据进行了荟萃分析,通过汇总估计来计算围手术期使用这些无创CO监测装置的精度。作者从系统评价中收集数据,以计算以下4个变量:(1)bolus TD测试方法与无创参考方法(bias)的平均差的合并估计,(2)偏差的标准差(precision)的合并估计,(3)偏差95%置信区间的合并估计,(4)误差百分比(PE)的合并估计。被测试方法和参考方法之间可接受的一致性定义为汇总估计(PE)为30%或更高。尽管它在重症监护管理中至关重要,但一氧化碳作为测量终末器官氧输送的基础,在临床环境中明显监测不足。新的无创技术和旧的监测方法有很多,包括脉搏波传递时间(PWTT)、无创脉搏廓线分析(niPCA)、部分CO2再呼吸(CO2r)和胸电生物阻抗(TEB),但在临床环境中“首选”的是传统的有创技术——大剂量TD。两种方法的平均CO为4.78 L/min。总体随机效应合并偏倚为- 0.13 L/min (- 2.38 ~ 2.12 L/min), PE为47%,具有较高的研究间敏感性异质性(I = 83%, P < 0.001)。尽管自21世纪初以来医疗技术取得了许多进步,但与大剂量TD相比,TEB和CO2r并没有显示出显著增加的一致性(在该荟萃分析中,TEB的PE在1999年为37%,2010年为43%,2016年为42%;CO2r PE与2010年相似:44.5%对40%)。最近的技术,如PWTT和niPCA, PWTT的PE为62%,niPCA为45%。完全无创的CO测量技术没有达到可接受的一致水平。所有无创技术的pe均高于30%的预设阈值
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引用次数: 1
期刊
Survey of Anesthesiology
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