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Determination of ED50 of hydromorphone for postoperative analgesia following cesarean delivery. 氢吗啡酮用于剖宫产术后镇痛的ED50测定。
Pub Date : 2016-12-01 DOI: 10.1097/01.sa.0000515850.94080.6f
G. Lynde
BACKGROUNDMorphine is the most common opioid injected into the intrathecal space for postoperative analgesia following cesarean delivery, but ongoing medication shortages have resulted in limited availability. One proposed morphine alternative is hydromorphone. Studies investigating its use in post-cesarean analgesia are limited. This study was conducted to determine the median effective dose of intrathecal hydromorphone 12h postpartum.METHODSTwenty healthy women undergoing elective cesarean delivery were recruited into this study. Hydromorphone doses were determined using the up-down sequential method. The study dose of hydromorphone started at 6μg and was raised or lowered by 2μg depending on the 12-h efficacy of the preceding participant's dose. Pain scores of <3/10 were considered successful and the subsequent patient received a lower dose. Participants received 0.5% bupivacaine 12.5mg, fentanyl 25μg, and the study dose of hydromorphone as a single intrathecal injection.RESULTSTen of 20 participants reported an effective hydromorphone dosage 12h post-injection. The median effective hydromorphone dosage was 4.6μg (95% CI 3.72 to 5.48μg) based on participants' reported visual analog pain scores of <3/10. No significant side effects or adverse outcomes were observed.CONCLUSIONIntrathecal hydromorphone may be an effective alternative to morphine for post-cesarean pain management. The amount of intrathecal hydromorphone necessary to provide analgesia at 12h postoperatively may be significantly lower than doses currently in use. Further research should be performed to identify the optimal dose of intrathecal hydromorphone for post-surgical pain relief.
背景:吗啡是剖宫产术后鞘内镇痛最常用的阿片类药物,但持续的药物短缺导致可用性有限。一种建议的吗啡替代品是氢吗啡酮。研究其在剖宫产后镇痛中的应用是有限的。本研究旨在确定产后12小时鞘内氢吗啡酮的中位有效剂量。方法选取20例择期剖宫产的健康妇女作为研究对象。采用上下序贯法测定氢吗啡酮剂量。氢吗啡酮的研究剂量从6μg开始,根据前一个参与者的剂量12小时的疗效增加或降低2μg。疼痛评分<3/10视为成功,后续患者接受较低剂量。参与者接受0.5%布比卡因12.5mg、芬太尼25μg和研究剂量的氢吗啡酮单次鞘内注射。结果20名参与者中有10人在注射后12h报告了有效的氢吗啡酮剂量。根据参与者报告的视觉模拟疼痛评分<3/10,氢吗啡酮的中位有效剂量为4.6μg (95% CI 3.72至5.48μg)。没有观察到明显的副作用或不良结果。结论鞘内氢吗啡酮可有效替代吗啡治疗剖宫产后疼痛。术后12小时提供镇痛所需的鞘内氢吗啡酮剂量可能明显低于目前使用的剂量。应进一步研究确定鞘内氢吗啡酮用于术后疼痛缓解的最佳剂量。
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引用次数: 7
Effect of body mass index in acute respiratory distress syndrome. 体重指数对急性呼吸窘迫综合征的影响。
Pub Date : 2016-12-01 DOI: 10.1097/01.sa.0000504593.63316.78
Davide Chiumello, Davide Chiumello, A. Colombo, I. Algieri, C. Mietto, E. Carlesso, F. Crimella, M. Cressoni, Michael Quintel, L. Gattinoni, L. Gattinoni
BACKGROUNDObesity is associated in healthy subjects with a great reduction in functional residual capacity and with a stiffening of lung and chest wall elastance, which promote alveolar collapse and hypoxaemia. Likewise, obese patients with acute respiratory distress syndrome (ARDS) could present greater derangements of respiratory mechanics than patients of normal weight.METHODSOne hundred and one ARDS patients were enrolled. Partitioned respiratory mechanics and gas exchange were measured at 5 and 15 cm H2O of PEEP with a tidal volume of 6-8 ml kg(-1) of predicted body weight. At 5 and 45 cm H2O of PEEP, two lung computed tomography scans were performed.RESULTSPatients were divided as follows according to BMI: normal weight (BMI≤25 kg m(-2)), overweight (BMI between 25 and 30 kg m(-2)), and obese (BMI>30 kg m(-2)). Obese, overweight, and normal-weight groups presented a similar lung elastance (median [interquartile range], respectively: 17.7 [14.2-24.8], 20.9 [16.1-30.2], and 20.5 [15.2-23.6] cm H2O litre(-1) at 5 cm H2O of PEEP and 19.3 [15.5-26.3], 21.1 [17.4-29.2], and 17.1 [13.4-20.4] cm H2O litre(-1) at 15 cm H2O of PEEP) and chest elastance (respectively: 4.9 [3.1-8.8], 5.9 [3.8-8.7], and 7.8 [3.9-9.8] cm H2O litre(-1) at 5 cm H2O of PEEP and 6.5 [4.5-9.6], 6.6 [4.2-9.2], and 4.9 [2.4-7.6] cm H2O litre(-1) at 15 cm H2O of PEEP). Lung recruitability was not affected by the body weight (15.6 [6.3-23.4], 15.7 [9.8-22.2], and 11.3 [6.2-15.6]% for normal-weight, overweight, and obese groups, respectively). Lung gas volume was significantly lower whereas total superimposed pressure was significantly higher in the obese compared with the normal-weight group (1148 [680-1815] vs 827 [686-1213] ml and 17.4 [15.8-19.3] vs 19.3 [18.6-21.7] cm H2O, respectively).CONCLUSIONSObese ARDS patients do not present higher chest wall elastance and lung recruitability.
背景:在健康受试者中,肥胖与功能剩余容量的大幅减少以及肺和胸壁弹性的加强有关,这可促进肺泡塌陷和低氧血症。同样,患有急性呼吸窘迫综合征(ARDS)的肥胖患者可能比正常体重的患者出现更大的呼吸力学紊乱。方法纳入101例ARDS患者。在5和15 cm H2O的PEEP下,以预测体重的6-8 ml kg(-1)的潮气量测量分割呼吸力学和气体交换。在5和45 cm H2O PEEP时,进行两次肺部计算机断层扫描。结果按BMI分为正常体重(BMI≤25 kg m(-2))、超重(BMI在25 ~ 30 kg m(-2)之间)、肥胖(BMI>30 kg m(-2))。肥胖、超重和正常体重组肺弹性(中位数[四分位数范围]分别为:呼气末正压5 cm H2O时17.7[14.2-24.8]、20.9[16.1-30.2]和20.5 [15.2-23.6]cm H2O升(-1),呼气末正压15 cm H2O时19.3[15.5-26.3]、21.1[17.4-29.2]和17.1 [13.4-20.4]cm H2O升(-1))和胸弹性(分别为:4.9[3.1-8.8], 5.9[3.8-8.7]和7.8 [3.9-9.8]cm H2O升(-1)在5 cm H2O的PEEP和6.5[4.5-9.6],6.6[4.2-9.2]和4.9 [2.4-7.6]cm H2O升(-1)在15 cm H2O的PEEP)。肺再生能力不受体重的影响(正常体重、超重和肥胖组分别为15.6%[6.3-23.4]、15.7%[9.8-22.2]和11.3[6.2-15.6]%)。与正常体重组相比,肥胖组肺气量显著降低,而总叠加压显著升高(分别为1148[680-1815]对827 [686-1213]ml和17.4[15.8-19.3]对19.3 [18.6-21.7]cm H2O)。结论急性呼吸窘迫综合征患者胸壁弹性和肺功能不明显增高。
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引用次数: 35
Higher Dead Space Is Associated With Increased Mortality in Critically Ill Children 较高的死亡空间与危重儿童死亡率增加有关
Pub Date : 2016-12-01 DOI: 10.1097/01.sa.0000504599.99381.9d
A. Bhalla, S. Belani, Dennis Leung, C. Newth, R. Khemani
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引用次数: 1
Magnesium sulfate improves postoperative analgesia in laparoscopic gynecologic surgeries: a double-blind randomized controlled trial. 硫酸镁改善腹腔镜妇科手术术后镇痛:一项双盲随机对照试验。
Pub Date : 2016-11-01 DOI: 10.1097/SA.0000000000000296
A. M. Sousa, G. M. Rosado, Jose de S Neto, G. Guimarães, H. Ashmawi
STUDY OBJECTIVEThe aim of this study is to compare the analgesic effect of intravenous infusion of magnesium sulfate to ketorolac during laparoscopic surgeries.DESIGNDouble-blind randomized controlled trial.SETTINGUniversity-affiliated teaching hospital.PATIENTSSixty women submitted to laparoscopic gynecologic oncology surgeries.INTERVENTIONSIntravenous ketorolac 30 mg in bolus followed by saline infusion (group K), intravenous magnesium sulfate 20 mg/kg in bolus followed by magnesium 2 mg kg(-1) h(-1) (group M) or intravenous saline solution 20 mL in bolus followed by saline infusion during the entire procedure (group S).MEASUREMENTSPostoperative pain, nausea, vomiting, sedation, opioid consumption, time to first dose of analgesic.MAIN RESULTSMagnesium sulfate reduced opioid consumption compared with placebo in the postoperative, but not in the intraoperative, period. Nausea, not vomiting, was reduced in ketorolac but not in the magnesium group. Pain intensity was higher in placebo than in the other 2 groups during all periods of observation. In the first 60 minutes, pain intensity was lower in the magnesium than in the ketorolac or the placebo group.CONCLUSIONIntraoperative magnesium sulfate improves postoperative pain control, acting as an opioid-sparing adjuvant, and is similar to ketorolac 30 mg administered in the beginning of surgery.
研究目的比较腹腔镜手术中静脉滴注硫酸镁与酮罗拉酸的镇痛效果。设计双盲随机对照试验。学校附属教学医院。病人:60名妇女接受腹腔镜妇科肿瘤手术。干预措施:K组静脉滴注酮洛酸30 mg/kg,随后滴注生理盐水(K组),M组静脉滴注硫酸镁20 mg/kg,随后滴注2 mg kg(-1) h(-1) (M组)或全程静脉滴注生理盐水溶液20 mL,随后滴注生理盐水(S组)。测量术后疼痛、恶心、呕吐、镇静、阿片类药物消耗、至首次给药时间。主要结果:与安慰剂相比,硫酸镁在术后减少了阿片类药物的消耗,但在术中没有减少。酮咯酸减轻了恶心,而不是呕吐,但镁组没有。在所有观察期间,安慰剂组的疼痛强度均高于其他两组。在最初的60分钟内,镁组的疼痛强度低于酮罗拉酸组或安慰剂组。结论术中硫酸镁可改善术后疼痛控制,可作为阿片类药物的辅助剂,其作用与术初给予酮罗拉酸30mg相似。
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引用次数: 30
Avoiding Repeated Attempts at Tracheal Intubation: Can Videolaryngoscopes Be the Answer? 避免气管插管的重复尝试:视频喉镜能解决问题吗?
Pub Date : 2016-10-01 DOI: 10.1097/01.sa.0000513244.79834.b3
T. Asai
Tracheal intubation is a common practice. But multiple attempts can cause airway obstruction and ensuing complications. Guidelines have strongly advised against making multiple tracheal intubation attempts. Many techniques have been described to improve the chances of successful intubation with traditional laryngoscopes (Macintosh and Miller). However, the rate of difficulty has not been significantly reduced. With the modern technological advancements, devices such as video laryngoscopes, fiberoptic bronchoscopes, supraglottic airways (as a conduit for tracheal intubation), lighted stylets, and optical stylets offer alternate options. Aziz et al developed a survey on alternate options used in instanceswhere the conventional methods such as laryngoscope had failed. The authors wanted to retrospectively ascertain the success rates of intubation using these modern devices. A total number of 1427 cases were reviewed. It was observed that video laryngoscopes had the highest success rate (92%) when compared with supraglottic airways (78%), fiberoptic bronchoscope (78%), lighted stylets (77%), and optical stylets (67%). However, because this study was retrospective, selection bias could not be ruled out, and definitive conclusion should not be drawn. Although video
气管插管是一种常见的做法。但多次尝试会导致气道阻塞和随之而来的并发症。指南强烈建议不要尝试多次气管插管。许多技术已经被描述来提高用传统喉镜插管成功的机会(Macintosh和Miller)。然而,难度并没有显著降低。随着现代技术的进步,诸如视频喉镜、纤维支气管镜、声门上气道(作为气管插管的导管)、灯光导管和光学导管等设备提供了替代选择。Aziz等人开展了一项调查,在喉镜等常规方法失败的情况下使用替代方法。作者想回顾性地确定使用这些现代设备插管的成功率。共审查了1427个案件。与声门上气道(78%)、纤维支气管镜(78%)、灯光插管(77%)和光学插管(67%)相比,视频喉镜的成功率最高(92%)。然而,由于本研究是回顾性的,不能排除选择偏倚,不能得出明确的结论。虽然视频
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引用次数: 8
Overinflation of the Cuff and Pressure on the Neck Reduce the Preventive Effect of Supraglottic Airways on Pulmonary Aspiration: An Experimental Study in Human Cadavers 袖带过度膨胀和颈部压力降低声门上气道对肺误吸的预防作用:人体尸体的实验研究
Pub Date : 2016-10-01 DOI: 10.1097/SA.0000000000000256
M. Hensel, W. Schmidbauer, D. Geppert, S. Sehner, G. Bogusch, T. Kerner
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引用次数: 0
"To Reverse or Not To Reverse?": The Answer Is Clear! “反转还是不反转?”答案很清楚!
Pub Date : 2016-10-01 DOI: 10.1097/01.sa.0000513239.94409.ee
G. Murphy, A. Kopman
Anesthesiology, V 125 • No 4 611 October 2016 B y the late 1980s, it was well recognized that undetected postoperative residual neuromuscular block (PRNB) was a common occurrence in most postanesthesia care units (PACUs).1–4 However, an editorial in 1989 noted that there was little, if any, objective evidence to validate the hypothesis that PRNB was associated with long-term or even transient adverse respiratory outcomes.5 In the two and a half decades since the editorial by Miller5 was published, outcome data regarding this important patient safety issue have slowly accumulated, but the relevant database remains quite sparse. In this issue of ANestHesIology, Bulka et al.6 provide an important addition to the small list of studies that attempt to examine the long-term consequences of PRNB. They report two main findings: (1) the use of neuromuscular blocking agents (NMBAs) was associated with a higher absolute rate of postoperative pneumonia (PoP) when compared to matched cases where patients did not receive relaxants and (2) failure to reverse NMBAs at the end of surgery was associated with a 2.25-fold increase in the incidence of PoP. Why should these findings be less than surprising? Bulka et al.6 noted that the incidence rate ratio (1.79) for PoP was significantly higher in patients who received NMBAs. This observation is consistent with the findings from several large database investigations, which have described an association between intraoperative NMBA use and major morbidity and mortality. More than 60 yr ago, Beecher and todd7 reported that the risk of death related to anesthesia was six times higher in patients receiving NMBAs compared to those administered no muscle relaxants. An analysis of data collected over a 10-yr period (1967 to 1976) involving 240,483 anesthetics revealed that “respiratory inadequacy after myoneural blockade” was the second most common cause of death after surgery.8 similarly, a study from great Britain reported that postoperative respiratory failure secondary to dosing of NMBAs was a primary cause of mortality.9 In a large prospective study, the use of the long-acting NMBA pancuronium entailed a higher risk of postoperative pulmonary complications.10 More recent studies reported that patients administered NMBAs had a higher risk of postoperative desaturations and need for reintubation11 and that those given high doses of NMBAs had an increased risk of postoperative respiratory complications.12 The increased incidence of morbidity and mortality reported in patients administered NMBAs is likely secondary to PRNB. Incomplete neuromuscular recovery during a vulnerable postoperative period (between tracheal extubation and achieving a train-of-four [toF] ratio of less than 0.9 in the PACU) may impair upper airway patency, protective airway reflexes, breathing, swallowing, and coughing, resulting in an increased risk of significant respiratory events (like PoP) and death. Data demon
在20世纪80年代末,人们普遍认为,在大多数麻醉后护理单位(pacu)中,未发现的术后残留神经肌肉阻滞(PRNB)是常见的。1-4然而,1989年的一篇社论指出,几乎没有客观证据证实PRNB与长期甚至短暂的不良呼吸结果相关的假设自Miller5的社论发表以来的25年里,关于这一重要的患者安全问题的结果数据慢慢积累起来,但相关数据库仍然相当稀少。在本期的《麻醉学》杂志上,Bulka等人6为试图检查PRNB长期后果的少量研究提供了重要的补充。他们报告了两个主要发现:(1)与未接受松弛剂的患者相比,使用神经肌肉阻滞剂(nmba)与术后肺炎(PoP)的绝对发生率较高相关;(2)手术结束时未能逆转nmba与PoP发生率增加2.25倍相关。为什么这些发现不足为奇呢?Bulka等人6指出,接受nmba治疗的患者的PoP发病率比(1.79)明显更高。这一观察结果与几项大型数据库调查的结果一致,这些调查描述了术中使用NMBA与主要发病率和死亡率之间的关联。60多年前,Beecher和todd7报道,接受nmba的患者与未使用肌肉松弛剂的患者相比,与麻醉相关的死亡风险高6倍。对10年间(1967年至1976年)240,483种麻醉药收集的数据的分析显示,“肌神经阻滞后呼吸功能不全”是手术后死亡的第二大常见原因。类似地,英国的一项研究报告称,nmba剂量引起的术后呼吸衰竭是导致死亡的主要原因在一项大型前瞻性研究中,使用长效NMBA泮库溴铵会增加术后肺部并发症的风险最近的研究报道,给予NMBAs的患者术后发生去饱和的风险更高,需要重新插管,并且给予高剂量NMBAs的患者术后发生呼吸系统并发症的风险更高据报道,服用nmba的患者发病率和死亡率的增加可能是继发于PRNB。术后脆弱期(从气管拔管到PACU中toF小于0.9之间)神经肌肉恢复不完全可能损害上气道通畅、气道保护性反射、呼吸、吞咽和咳嗽,导致重大呼吸事件(如PoP)和死亡的风险增加。数据显示神经肌肉阻滞逆转失败与术后不良结果之间的关联不太确定。一项大型病例对照数据库调查显示,与降低死亡率和昏迷相关的初级麻醉管理特点是nmbas效果的逆转在"倒车还是不倒车? "
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引用次数: 28
Caring for the Jehovahʼs Witness Parturient 照顾耶和华见证人的产妇
Pub Date : 2016-10-01 DOI: 10.1097/SA.0000000000000253
C. Mason, C. Tran
A llogeneic blood transfusion is considered by Jehovah's Witnesses to be a violation of God's law, and this can present many ethical, legal, and health concerns when medical care is needed. Especially in cases dealing with childbirth, where substantial blood loss can occur, having an efficient and effective plan and line of communication between the parturient and her caregivers is crucial to ensure the most beneficial outcome for the patient while respecting her constitutionally protected right to make an informed choice about her medical treatment. The authors of this article reviewed concepts and care options as they related to the perioperative care of a Jehovah's Witness parturient. Courts have upheld that competent pregnant women have the right of bodily self-determination and therefore can refuse blood transfusion. This article established the importance of having a patient's care preferences and directives clearly expressed. For example, patients may do this in writing by using an advance health care directive, which would clearly delineate their personal decisions not only on blood transfusion but also in regard to derivatives of plasma or cellular blood components and autologous blood management, which are “conscience” items on which Witnessesmake individual decisions. Although patients have the right to decline treatments, the physician also has a duty to disclose any risks associated with refusing a treatment and to educate patients on alternative treatments. Communication between parturients and their medical caregivers is key throughout the entire treatment process. This article suggests using a perioperative surgical home model to coordinate care throughout the entire surgical experience as this model is fitting for the unique needs of the Jehovah's Witness population. The use of pharmacologic therapies is also recommended when alternatives to blood transfusion are needed. The authors of this article also suggest several options for reducing perioperative transfusion requirements and medical options for Jehovah's Witness patients who experience a massive hemorrhage. Blood conservation techniques should be considered as Jehovah's Witnesses have differing opinions about what treatments are allowed. Although some Jehovah's Witness parturients may consent to the use of acute normovolemic hemodilution and blood cell salvage, other Witnesses may have stricter specifications. Anesthetic and surgical techniques should be executed in a way that decreases blood loss. Again, the authors emphasize communication between patients and caregivers to expedite any necessary interventions in the threat or event of hemorrhage. The care of a Jehovah's Witness parturient must encompass all medical, ethical, and legal considerations. This article stresses the establishment of a communicative and comprehensive model early in the antepartum period that can be maintained throughout
异基因输血被耶和华见证人认为是违反上帝的律法,当需要医疗护理时,这可能会带来许多伦理、法律和健康方面的问题。特别是在可能发生大量失血的分娩情况下,在产妇及其护理人员之间制定高效和有效的计划和沟通渠道至关重要,以确保患者获得最有利的结果,同时尊重受宪法保护的对其医疗作出知情选择的权利。这篇文章的作者回顾了概念和护理方案,因为他们涉及到围手术期护理耶和华见证人的产妇。法院坚持认为,有能力的孕妇有身体自决的权利,因此可以拒绝输血。这篇文章建立了病人的护理偏好和指示明确表达的重要性。例如,病人可以使用预先保健指示,以书面形式做到这一点,该指示将明确规定他们的个人决定,不仅是输血,而且还包括血浆或细胞血液成分的衍生物和自体血液管理,这些是证人作出个人决定的"良心"项目。虽然病人有权拒绝治疗,但医生也有责任告知病人拒绝治疗的任何风险,并教育病人选择其他治疗方法。在整个治疗过程中,患者和医疗护理人员之间的沟通是关键。这篇文章建议使用围手术期的家庭模式来协调整个手术过程中的护理,因为这种模式适合耶和华见证会人口的独特需求。当需要替代输血时,也建议使用药物治疗。这篇文章的作者还提出了减少围手术期输血需求的几种选择,以及对经历大出血的耶和华见证人患者的医疗选择。应该考虑血液保存技术,因为耶和华见证人对允许的治疗方法有不同的意见。虽然一些耶和华见证人的产妇可能同意使用急性等容血液稀释和血细胞回收,但其他见证人可能有更严格的规定。麻醉和手术技术应以减少失血的方式执行。再次,作者强调患者和护理人员之间的沟通,以加快任何必要的干预威胁或出血事件。耶和华见证人的产妇护理必须包括所有医疗、伦理和法律方面的考虑。本文强调在产前早期就建立一种可以贯穿始终的沟通和综合模式
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引用次数: 5
Double-lumen tubes and auto-PEEP during one-lung ventilation. 单肺通气时双腔管和自动peep。
Pub Date : 2016-10-01 DOI: 10.1097/01.sa.0000490231.29771.01
J. Spaeth, M. Ott, W. Karzai, A. Grimm, S. Wirth, Stefan Schumann, T. Loop
BACKGROUNDDouble-lumen tubes (DLT) are routinely used to enable one-lung-ventilation (OLV) during thoracic anaesthesia. The flow-dependent resistance of the DLT's bronchial limb may be high as a result of its narrow inner diameter and length, and thus potentially contribute to an unintended increase in positive end-expiratory pressure (auto-PEEP). We therefore studied the impact of adult sized DLTs on the dynamic auto-PEEP during OLV.METHODSIn this prospective clinical study, dynamic auto-PEEP was determined in 72 patients undergoing thoracic surgery, with right- and left-sided DLTs of various sizes. During OLV, air trapping was provoked by increasing inspiration to expiration ratio from 1:2 to 2:1 (five steps). Based on measured flow rate, airway pressure (Paw) and bronchial pressure (Pbronch), the pressure gradient across the DLT (ΔPDLT) and the total auto-PEEP in the respiratory system (i.e. the lungs, the DLT and the ventilator circuit) were determined. Subsequently the DLT's share in total auto-PEEP was calculated.RESULTSΔPDLT was 2.3 (0.7) cm H2O over the entire breathing cycle. At the shortest expiratory time the mean total auto-PEEP was 2.9 (1.5) cm H2O (range 0-5.9 cm H2O). The DLT caused 27 to 31% of the total auto-PEEP. Size and side of the DLT's bronchial limb did not impact auto-PEEP significantly.CONCLUSIONSAlthough the DLT contributes to the overall auto-PEEP, its contribution is small and independent of size and side of the DLT's bronchial limb. The choice of DLT does not influence the risk of auto-PEEP during OLV to a clinically relevant extent.CLINICAL TRIAL REGISTRATIONDRKS00005648.
背景:在胸部麻醉期间,双腔管(DLT)通常用于实现单肺通气(OLV)。由于DLT的内径和长度较窄,其支气管肢体的血流依赖性阻力可能很高,因此可能导致呼气末正压(自动peep)的意外增加。因此,我们研究了成人大小的dlt对OLV期间动态自动peep的影响。方法在这项前瞻性临床研究中,对72例胸外科手术患者进行动态自动peep测定,这些患者有不同大小的左右侧dlt。在OLV过程中,通过将吸气与呼气比从1:2增加到2:1(五个步骤)来引起空气捕获。根据测量的流速、气道压力(Paw)和支气管压力(phbronch),确定DLT上的压力梯度(ΔPDLT)和呼吸系统(即肺、DLT和呼吸机回路)的总自动peep。随后计算DLT在总自动peep中的份额。RESULTSΔPDLT在整个呼吸周期中为2.3 (0.7)cm H2O。在最短呼气时间,平均总自动peep为2.9 (1.5)cm H2O(范围0-5.9 cm H2O)。DLT引起了总自动peep的27 - 31%。DLT支气管肢体的大小和侧边对自动peep无明显影响。结论虽然DLT对整体的自动peep有贡献,但其贡献较小,且与DLT支气管肢的大小和侧边无关。在临床相关程度上,DLT的选择并未影响OLV期间的自peep风险。临床试验注册drks00005648。
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引用次数: 9
No evidence for contraindications to the use of propofol in adults allergic to egg, soy or peanut†. 没有证据表明对鸡蛋、大豆或花生过敏的成年人使用异丙酚有禁忌症。
Pub Date : 2016-10-01 DOI: 10.1097/01.sa.0000490336.54904.62
L. L. Asserhøj, H. Mosbech, M. Krøigaard, L. H. Garvey
BACKGROUNDPropofol is thought to be a potential cause of allergic reactions in patients allergic to egg, soy or peanut, since current formulations contain an emulsion that includes egg lecithin and soybean oil. However, other than six case reports lacking in confirmatory evidence of an allergic reaction, there is no evidence linking the two types of allergies. The aim of this study was to examine the frequency of propofol allergy and to investigate if patients with specific immunoglobulin E (IgE) to egg, soy or peanut tolerated propofol.METHODSStudy A examined the frequency of propofol allergy in 273 patients systematically investigated for suspected perioperative allergic reactions. Of these, 153 had been exposed to propofol and underwent skin tests and intravenous provocation. Study B retrospectively investigated propofol exposure and tolerance in 520 adult patients with a positive specific IgE to egg, soy or peanut.RESULTSFour of the 153 propofol-exposed patients (2.6%) investigated in study A were diagnosed with propofol allergy. Of these, three tested positive only on intravenous provocation. None of the four had allergic symptoms when eating egg, soy or peanut and none had detectable levels of specific IgE to egg or soy in their serum. In study B we found no signs of allergic reactions towards propofol in 171 retrieved anaesthetic charts from 99 patients with specific IgE to egg, soy or peanut.CONCLUSIONNo connection between allergy to propofol and allergy to egg, soy or peanut was found. The present practice of choosing alternatives to propofol in patients with this kind of food allergy is not evidence based and should be reconsidered.
背景丙泊酚被认为是对鸡蛋、大豆或花生过敏的患者产生过敏反应的潜在原因,因为目前的配方中含有鸡蛋卵磷脂和大豆油的乳剂。然而,除了6例缺乏过敏反应确凿证据的病例报告外,没有证据表明这两种类型的过敏之间存在联系。本研究的目的是检查异丙酚过敏的频率,并调查对鸡蛋、大豆或花生具有特异性免疫球蛋白E (IgE)的患者是否耐受异丙酚。方法研究A系统调查了273例疑似围手术期过敏反应患者的异丙酚过敏发生率。其中153人接触过异丙酚,并接受了皮肤试验和静脉注射刺激。研究B回顾性调查了520例对鸡蛋、大豆或花生特异性IgE阳性的成年患者异丙酚暴露和耐受性。结果A研究中153例丙泊酚暴露患者中有4例(2.6%)诊断为丙泊酚过敏。其中3例仅在静脉注射刺激时检测呈阳性。这四个人在吃鸡蛋、大豆或花生时都没有过敏症状,他们的血清中也没有检测到对鸡蛋或大豆的特定IgE水平。在研究B中,我们从99例对鸡蛋、大豆或花生有特定IgE的患者中检索到171例麻醉图表,没有发现对异丙酚过敏的迹象。结论异丙酚过敏与鸡蛋、大豆、花生过敏无相关性。目前在这类食物过敏患者中选择异丙酚替代品的做法是没有证据基础的,应该重新考虑。
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引用次数: 98
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Survey of Anesthesiology
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