Pub Date : 2024-05-18DOI: 10.1080/00397911.2024.2345380
Shital B. Sukale , Dipak S. Aher , Laxmikant D. Chavan , Kiran R. Khillare , Sunil G. Shankarwar
A series of highly reusable heterogeneous catalysts (10-40 wt.% SiMo12/Al2O3), consisting of molybdosilicic acid (SiMo12) impregnated on alumina (Al2O3) support was synthesized by the wetness impregnation method. The physicochemical properties of synthesized catalyst were studied using FT-IR, XRD, SEM, EDX, TEM, BET and TG-DTA analysis techniques. The study proves that the synthesized SiMo12 catalyst efficiently incorporated on the surface of Al2O3. The catalytic activity of prepared catalyst was investigated for the synthesis of pyranopyrazole(6-amino-4-phenyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5carbonitrile) via cyclocondensation reaction of aldehydes, malononitrile, hydrazine hydrate and ethyl-acetoacetate under solvent-free conditions. Among different catalysts, 30% SiMo12 supported on to Al2O3 showed the highest catalytic activity. High yield, shorter reaction time, operational simplicity, solvent-free conditions and reusability of the catalyst are the distinct features of this protocol.
{"title":"Synthesis and characterization of alumina supported molybdosilicic acid (SiMo12/Al2O3): Efficient solid acid catalyst for the synthesis of pyranopyrazole derivatives","authors":"Shital B. Sukale , Dipak S. Aher , Laxmikant D. Chavan , Kiran R. Khillare , Sunil G. Shankarwar","doi":"10.1080/00397911.2024.2345380","DOIUrl":"10.1080/00397911.2024.2345380","url":null,"abstract":"<div><p>A series of highly reusable heterogeneous catalysts (10-40 wt.% SiMo<sub>12</sub>/Al<sub>2</sub>O<sub>3</sub>), consisting of molybdosilicic acid (SiMo<sub>12</sub>) impregnated on alumina (Al<sub>2</sub>O<sub>3</sub>) support was synthesized by the wetness impregnation method. The physicochemical properties of synthesized catalyst were studied using FT-IR, XRD, SEM, EDX, TEM, BET and TG-DTA analysis techniques. The study proves that the synthesized SiMo<sub>12</sub> catalyst efficiently incorporated on the surface of Al<sub>2</sub>O<sub>3.</sub> The catalytic activity of prepared catalyst was investigated for the synthesis of pyranopyrazole(6-amino-4-phenyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5carbonitrile) via cyclocondensation reaction of aldehydes, malononitrile, hydrazine hydrate and ethyl-acetoacetate under solvent-free conditions. Among different catalysts, 30% SiMo<sub>12</sub> supported on to Al<sub>2</sub>O<sub>3</sub> showed the highest catalytic activity. High yield, shorter reaction time, operational simplicity, solvent-free conditions and reusability of the catalyst are the distinct features of this protocol.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 10","pages":"Pages 826-842"},"PeriodicalIF":2.1,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140988661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-18DOI: 10.1080/00397911.2024.2346565
F. M. Alshareef , Zahra M. Alamshany , Sami A. Al-Harbi , Esam S. Allehyani , Magdy A. Ibrahim
The current study includes synthetic approaches for some linear heterocyclic compounds containing chromone moiety. Chromenopyridopyrimidine bearing amino-thione functions 4 was efficiently synthesized starting from 6,8-dimethylchromone-3-carbonitrile (1). The novel chromenopyridothiadiazolopyrimidines were synthesized through condensation of the key precursor 4 with some mono-electrophilic reagents. In addition, heteroannulated chromenopyridopyrimidothiadiazines were synthesized through condensation of compound 4 with some α-halogenated carbonyl reagents. The synthesized products were examined for their antimicrobial efficiency appearing remarkable activity against the inspected microorganisms especially compounds 7, 12 and 14. The synthesized products were inferred using analytical and spectral data.
{"title":"Novel annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3,4]thiadiazolo[3,2-a] pyrimidines and chromeno[3'',2'':5',6']pyrido[2',3':4,5]pyrimido[2,1-b][1,3,4] thiadiazines: Synthetic approaches and antimicrobial efficiency","authors":"F. M. Alshareef , Zahra M. Alamshany , Sami A. Al-Harbi , Esam S. Allehyani , Magdy A. Ibrahim","doi":"10.1080/00397911.2024.2346565","DOIUrl":"10.1080/00397911.2024.2346565","url":null,"abstract":"<div><p>The current study includes synthetic approaches for some linear heterocyclic compounds containing chromone moiety. Chromenopyridopyrimidine bearing amino-thione functions <strong>4</strong> was efficiently synthesized starting from 6,8-dimethylchromone-3-carbonitrile (<strong>1</strong>). The novel chromenopyridothiadiazolopyrimidines were synthesized through condensation of the key precursor <strong>4</strong> with some mono-electrophilic reagents. In addition, heteroannulated chromenopyridopyrimidothiadiazines were synthesized through condensation of compound <strong>4</strong> with some α-halogenated carbonyl reagents. The synthesized products were examined for their antimicrobial efficiency appearing remarkable activity against the inspected microorganisms especially compounds <strong>7</strong>, <strong>12</strong> and <strong>14</strong>. The synthesized products were inferred using analytical and spectral data.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 10","pages":"Pages 843-852"},"PeriodicalIF":2.1,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141050554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.1080/00397911.2024.2342316
Urvi J. Khengar , Dharti R. Bhandari , Rajesh H. Vekariya , Jinal A. Gajjar
Potassium phthalimide (PPI) and Potassium phthalimide-N-oxyl (POPINO) have emerged as a versatile and efficient catalyst in various organic synthesis reactions, playing a crucial role in the development of sustainable and environmentally friendly synthetic methodologies. This review highlights the catalytic applications of PPI and POPINO in diverse transformations, showcasing its potential as a valuable tool in modern organic synthesis. The multifaceted reactivity of PPI and POPINO has been explored in reactions such as nucleophilic substitutions, condensations, cycloadditions, and oxidation processes, making it an attractive catalyst for the synthesis of complex organic molecules.
邻苯二甲酰亚胺钾(PPI)和邻苯二甲酰亚胺钾-N-氧(POPINO)已成为各种有机合成反应中用途广泛的高效催化剂,在开发可持续和环境友好型合成方法中发挥着至关重要的作用。本综述重点介绍了 PPI 和 POPINO 在各种转化过程中的催化应用,展示了其作为现代有机合成重要工具的潜力。PPI 和 POPINO 在亲核取代、缩合、环加成和氧化过程等反应中具有多方面的反应活性,使其成为合成复杂有机分子的一种极具吸引力的催化剂。
{"title":"An overall development on catalytic applications of potassium phthalimide (PPI) and potassium phthalimide-N-oxyl (POPINO) in organic synthesis","authors":"Urvi J. Khengar , Dharti R. Bhandari , Rajesh H. Vekariya , Jinal A. Gajjar","doi":"10.1080/00397911.2024.2342316","DOIUrl":"10.1080/00397911.2024.2342316","url":null,"abstract":"<div><p>Potassium phthalimide (PPI) and Potassium phthalimide<em>-N-</em>oxyl (POPINO) have emerged as a versatile and efficient catalyst in various organic synthesis reactions, playing a crucial role in the development of sustainable and environmentally friendly synthetic methodologies. This review highlights the catalytic applications of PPI and POPINO in diverse transformations, showcasing its potential as a valuable tool in modern organic synthesis. The multifaceted reactivity of PPI and POPINO has been explored in reactions such as nucleophilic substitutions, condensations, cycloadditions, and oxidation processes, making it an attractive catalyst for the synthesis of complex organic molecules.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 12","pages":"Pages 935-952"},"PeriodicalIF":2.1,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.1080/00397911.2024.2324002
Chun Keng Thy , Yean Kee Lee , Iskandar Abdullah , Noorsaadah Abd Rahman , Chin Fei Chee
The asymmetric Diels–Alder reaction of chalcone and isoprene has been accomplished by use of chiral titanium complexes. Notably, an enantiomeric excess as high as 61% and a regioselectivity of 95% have been achieved. The preparation of the chiral titanium complexes is simple and does not require the pre-installation of a chiral auxiliary. This study represents the first example of asymmetric Diels–Alder reaction between chalcone and isoprene.
{"title":"Asymmetric Diels–Alder reaction of chalcone and isoprene mediated by titanium-based complexes","authors":"Chun Keng Thy , Yean Kee Lee , Iskandar Abdullah , Noorsaadah Abd Rahman , Chin Fei Chee","doi":"10.1080/00397911.2024.2324002","DOIUrl":"10.1080/00397911.2024.2324002","url":null,"abstract":"<div><p>The asymmetric Diels–Alder reaction of chalcone and isoprene has been accomplished by use of chiral titanium complexes. Notably, an enantiomeric excess as high as 61% and a regioselectivity of 95% have been achieved. The preparation of the chiral titanium complexes is simple and does not require the pre-installation of a chiral auxiliary. This study represents the first example of asymmetric Diels–Alder reaction between chalcone and isoprene.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 8","pages":"Pages 636-644"},"PeriodicalIF":2.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140072732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Polyethyleneimine-supported cobalt (II) chloride as a novel polymeric nanocomposite acidic catalyst for the one-stage transesterification reaction of ethyl acetate with various alcohols is reported. The catalyst was characterized by Fourier transform infrared spectroscopy, X-ray powder diffraction, transmission electron microscopy, scanning electron microscopy, dynamic light scattering technique, and thermal gravimetric analysis. Furthermore, inductively coupled plasma and atomic absorption spectroscopy were used to determine the quantity of Cobalt nanoparticles in the catalyst. By adding the catalyst (0.10 g, 0.20 mol%) and n-hexane/chloroform (5.0 cm3) as solvent under reflux conditions, the studies demonstrated successful transesterification reactions with excellent yields (80–98%) and short reaction times (0.50–1.30 h) using various substrates on the scale of 1.0 mmol. Seven consecutive reactions could be performed on the catalyst without significantly decreasing its activity. The most noteworthy aspects of this process are its low cost, safety, and environmental friendliness due to the catalyst’s non-toxicity, straightforward operation, and effective outcomes.
报道了聚乙烯亚胺支撑的氯化钴 (II) 作为一种新型聚合物纳米复合酸性催化剂,用于乙酸乙酯与各种醇的一段式酯交换反应...
{"title":"Polyethyleneimine-immobilized CoCl2 nanoparticles: Synthesis, characterization, application as a new efficient and reusable nanocomposite catalyst for one-step transesterification reaction","authors":"Tahereh Darvishi , Sedigheh Azadi , Nooredin Goudarzian","doi":"10.1080/00397911.2024.2328287","DOIUrl":"10.1080/00397911.2024.2328287","url":null,"abstract":"<div><p>Polyethyleneimine-supported cobalt (II) chloride as a novel polymeric nanocomposite acidic catalyst for the one-stage transesterification reaction of ethyl acetate with various alcohols is reported. The catalyst was characterized by Fourier transform infrared spectroscopy, X-ray powder diffraction, transmission electron microscopy, scanning electron microscopy, dynamic light scattering technique, and thermal gravimetric analysis. Furthermore, inductively coupled plasma and atomic absorption spectroscopy were used to determine the quantity of Cobalt nanoparticles in the catalyst. By adding the catalyst (0.10 g, 0.20 mol%) and n-hexane/chloroform (5.0 cm<sup>3</sup>) as solvent under reflux conditions, the studies demonstrated successful transesterification reactions with excellent yields (80–98%) and short reaction times (0.50–1.30 h) using various substrates on the scale of 1.0 mmol. Seven consecutive reactions could be performed on the catalyst without significantly decreasing its activity. The most noteworthy aspects of this process are its low cost, safety, and environmental friendliness due to the catalyst’s non-toxicity, straightforward operation, and effective outcomes.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 8","pages":"Pages 672-693"},"PeriodicalIF":2.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140199332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.1080/00397911.2024.2324456
Wenjuan Li , Xiao Li , Hailong Hong , Ruijun Xie , Ning Zhu
An effective, green and eco-friendly method was developed to synthesize 1H-benzimidazole under microwave irradiation. The reactions of substituted o-phenylenediamine with DMF were efficiently promoted by butanoic acid, and the desired product 1H-benzimidazole derivatives were obtained in good to excellent yields. Compared with the conventional heating method, microwave irradiation significantly reduced the reaction time and improved the yields of the target products.
{"title":"Synthesis of 1H-benzimidazoles via the condensation of o-phenylenediamines with DMF promoted by organic acid under microwave irradiation","authors":"Wenjuan Li , Xiao Li , Hailong Hong , Ruijun Xie , Ning Zhu","doi":"10.1080/00397911.2024.2324456","DOIUrl":"10.1080/00397911.2024.2324456","url":null,"abstract":"<div><p>An effective, green and eco-friendly method was developed to synthesize 1<em>H</em>-benzimidazole under microwave irradiation. The reactions of substituted <em>o</em>-phenylenediamine with DMF were efficiently promoted by butanoic acid, and the desired product 1<em>H</em>-benzimidazole derivatives were obtained in good to excellent yields. Compared with the conventional heating method, microwave irradiation significantly reduced the reaction time and improved the yields of the target products.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 8","pages":"Pages 645-654"},"PeriodicalIF":2.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140044284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.1080/00397911.2024.2327047
David S. A. Haneen , Mohamed H. Hekal , Wael S. I. Abou-Elmagd , Wael M. El-Sayed
The poor selectivity, significant toxicity, high cost, and emergence of resistance of conventional chemotherapies are driving motive for the ongoing search for novel anticancer agents. New pyrano[2,3-c]pyrazolopyrimidines were synthesized and examined as antiproliferative agents, and the possible molecular mechanism(s) of action were explored. The mass and elemental analyses, alongside the IR,1H, and 13C NMR spectra, confirmed the proposed structures of the obtained compounds. Derivatives 4 and 7 demonstrated the best antiproliferative profile against HepG2 cancer cells at 4 µM, with a high selectivity index of ∼7–9 folds. They increased the S phase cell population by 51% and 40% and caused a 5- and 11-fold increase in the p21 protein. Compound 7 was superior in inhibiting HepG2 cell migration and delayed wound healing, reducing migration rates by 55% and 90%, respectively. Future studies on the pharmacokinetics, pharmacodynamics, antimetastatic, and antitumor activities in animal models would be a robust advance.
{"title":"Novel pyrano[2,3-c]pyrazolopyrimidines as promising anticancer agents: Design, synthesis, and cell cycle arrest of HepG2 cells at S phase","authors":"David S. A. Haneen , Mohamed H. Hekal , Wael S. I. Abou-Elmagd , Wael M. El-Sayed","doi":"10.1080/00397911.2024.2327047","DOIUrl":"10.1080/00397911.2024.2327047","url":null,"abstract":"<div><p>The poor selectivity, significant toxicity, high cost, and emergence of resistance of conventional chemotherapies are driving motive for the ongoing search for novel anticancer agents. New pyrano[2,3-<em>c</em>]pyrazolopyrimidines were synthesized and examined as antiproliferative agents, and the possible molecular mechanism(s) of action were explored. The mass and elemental analyses, alongside the IR,<sup>1</sup>H, and <sup>13</sup>C NMR spectra, confirmed the proposed structures of the obtained compounds. Derivatives <strong>4</strong> and <strong>7</strong> demonstrated the best antiproliferative profile against HepG2 cancer cells at 4 µM, with a high selectivity index of ∼7–9 folds. They increased the S phase cell population by 51% and 40% and caused a 5- and 11-fold increase in the p21 protein. Compound <strong>7</strong> was superior in inhibiting HepG2 cell migration and delayed wound healing, reducing migration rates by 55% and 90%, respectively. Future studies on the pharmacokinetics, pharmacodynamics, antimetastatic, and antitumor activities in animal models would be a robust advance.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 8","pages":"Pages 655-671"},"PeriodicalIF":2.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140125388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.1080/00397911.2024.2316718
Abouelhaoul El Alami , Hamid Sdassi , Said Bouzikri
Over the last few years, benzimidazole-heterocycle hybrid compounds have received considerable attention due to the wide spectrum of their biological property and many important chemical and pharmacological applications. These compounds have revealed antibacterial, antimicrobial, anticoagulant, antidiabetic and other activities, and they have been used as drugs in the market to treat several diseases. Furthermore, hybrid heterocyclic compounds possessing a benzimidazole skeleton exhibit significant complexing and anticorrosive properties. All of these applications have favored the development of a large number of synthetic strategies to prepare these heterocyclic systems in different reaction conditions. Many research articles on the synthesis of benzimidazole-heterocycle hybrid compounds have been reported in the literature. In this review, we present and discuss the synthetic routes of several benzimidazole-heterocycle hybrid compounds.
在过去几年中,苯并咪唑-杂环杂化化合物因其广泛的生物特性和许多重要的化学和医药用途而受到广泛关注。
{"title":"Review of synthesis process of benzimidazole-heterocycle hybrid compounds","authors":"Abouelhaoul El Alami , Hamid Sdassi , Said Bouzikri","doi":"10.1080/00397911.2024.2316718","DOIUrl":"10.1080/00397911.2024.2316718","url":null,"abstract":"<div><p>Over the last few years, benzimidazole-heterocycle hybrid compounds have received considerable attention due to the wide spectrum of their biological property and many important chemical and pharmacological applications. These compounds have revealed antibacterial, antimicrobial, anticoagulant, antidiabetic and other activities, and they have been used as drugs in the market to treat several diseases. Furthermore, hybrid heterocyclic compounds possessing a benzimidazole skeleton exhibit significant complexing and anticorrosive properties. All of these applications have favored the development of a large number of synthetic strategies to prepare these heterocyclic systems in different reaction conditions. Many research articles on the synthesis of benzimidazole-heterocycle hybrid compounds have been reported in the literature. In this review, we present and discuss the synthetic routes of several benzimidazole-heterocycle hybrid compounds.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 8","pages":"Pages 613-635"},"PeriodicalIF":2.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139756854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.1080/00397911.2024.2329245
Vikas S. Patil , Gayathri Chunduri , Balaram Kiran Avasarala , Gangaiah L , Pasham Yoganand , Kola Srinivas , Murali Koparala , Nagaraju Devunuri
A catalyst free oxone mediated synthesizing N-alkyl 1, 4-dihydroquinoxaline-2,3-dione has been developed by oxidation of the N-alkyl quinoxalin-2(1H)-one. The developed method is a novel, safest, cost-effective, industrially viable method and applicable for N-substituted and without substitution of 1,4-dihydroquinoxaline-2,3-dione. Consequently, the process is applicable to a broad spectrum of functionality. The reaction can be performed in all organic solvents without any further heating with an extended time and without generating side products. This novel synthetic methodology using Oxone is believed to be the shortest and most efficient to prepare various key intermediates which can be used for further derivatization to make the different biologically active molecules, the key feature of this methodology is not solvent specific, all organic solvents giving the optimum purity and quality using the same reaction condition.
{"title":"The Lacunae identified in processing, analyzing and finding means of catalyst free Oxone mediated through C-3 oxidation of N-alkyl quinoxalin-2(1h)-one","authors":"Vikas S. Patil , Gayathri Chunduri , Balaram Kiran Avasarala , Gangaiah L , Pasham Yoganand , Kola Srinivas , Murali Koparala , Nagaraju Devunuri","doi":"10.1080/00397911.2024.2329245","DOIUrl":"10.1080/00397911.2024.2329245","url":null,"abstract":"<div><p>A catalyst free oxone mediated synthesizing N-alkyl 1, 4-dihydroquinoxaline-2,3-dione has been developed by oxidation of the N-alkyl quinoxalin-2(1<em>H</em>)-one. The developed method is a novel, safest, cost-effective, industrially viable method and applicable for N-substituted and without substitution of 1,4-dihydroquinoxaline-2,3-dione. Consequently, the process is applicable to a broad spectrum of functionality. The reaction can be performed in all organic solvents without any further heating with an extended time and without generating side products. This novel synthetic methodology using Oxone is believed to be the shortest and most efficient to prepare various key intermediates which can be used for further derivatization to make the different biologically active molecules, the key feature of this methodology is not solvent specific, all organic solvents giving the optimum purity and quality using the same reaction condition.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 8","pages":"Pages 694-708"},"PeriodicalIF":2.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140147791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.1080/00397911.2024.2335638
Jiecheng Zheng , Feng Gong , Wei Wang , Yue Wu , Dezhang Zhao , Tianyuan Zhang , WenWen Yang , Zongjie Gan
A broad scope of quinazolin-4(3H)-ones or benzothiadiazine 1,1-dioxides was obtained via a transition-metal free and convenient method. This approach involving KHSO4 promoted cyclization and dehydration between diverse functionalized 2-aminobenzamides or 2-aminobenzenesulfonamides and N, N-dimethylformamide derivatives. The protocol offers moderate to excellent yields (45%-93%) under mild condition in a short of reaction time of 6 hours. The use of an environment-friendly and less expensive catalyst KHSO4 also makes this protocol more attractive.
{"title":"KHSO4 promoted practical synthesis of quinazolin-4(3H)-ones and benzothiadiazine 1,1-dioxides","authors":"Jiecheng Zheng , Feng Gong , Wei Wang , Yue Wu , Dezhang Zhao , Tianyuan Zhang , WenWen Yang , Zongjie Gan","doi":"10.1080/00397911.2024.2335638","DOIUrl":"https://doi.org/10.1080/00397911.2024.2335638","url":null,"abstract":"<div><p>A broad scope of quinazolin-4(<em>3H</em>)-ones or benzothiadiazine 1,1-dioxides was obtained via a transition-metal free and convenient method. This approach involving KHSO<sub>4</sub> promoted cyclization and dehydration between diverse functionalized 2-aminobenzamides or 2-aminobenzenesulfonamides and <em>N, N</em>-dimethylformamide derivatives. The protocol offers moderate to excellent yields (45%-93%) under mild condition in a short of reaction time of 6 hours. The use of an environment-friendly and less expensive catalyst KHSO<sub>4</sub> also makes this protocol more attractive.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 9","pages":"Pages 758-768"},"PeriodicalIF":2.1,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}