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Synthesis and characterization of alumina supported molybdosilicic acid (SiMo12/Al2O3): Efficient solid acid catalyst for the synthesis of pyranopyrazole derivatives 氧化铝支撑的钼硅酸(SiMo 12 /Al 2 O 3)的合成与表征:合成吡喃并唑衍生物的高效固体酸催化剂
IF 2.1 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-05-18 DOI: 10.1080/00397911.2024.2345380
Shital B. Sukale , Dipak S. Aher , Laxmikant D. Chavan , Kiran R. Khillare , Sunil G. Shankarwar

A series of highly reusable heterogeneous catalysts (10-40 wt.% SiMo12/Al2O3), consisting of molybdosilicic acid (SiMo12) impregnated on alumina (Al2O3) support was synthesized by the wetness impregnation method. The physicochemical properties of synthesized catalyst were studied using FT-IR, XRD, SEM, EDX, TEM, BET and TG-DTA analysis techniques. The study proves that the synthesized SiMo12 catalyst efficiently incorporated on the surface of Al2O3. The catalytic activity of prepared catalyst was investigated for the synthesis of pyranopyrazole(6-amino-4-phenyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5carbonitrile) via cyclocondensation reaction of aldehydes, malononitrile, hydrazine hydrate and ethyl-acetoacetate under solvent-free conditions. Among different catalysts, 30% SiMo12 supported on to Al2O3 showed the highest catalytic activity. High yield, shorter reaction time, operational simplicity, solvent-free conditions and reusability of the catalyst are the distinct features of this protocol.

采用湿法浸渍法合成了一系列高度可重复使用的异相催化剂(10-40 wt.% SiMo12/Al2O3),这些催化剂由浸渍在氧化铝(Al2O3)载体上的钼硅酸(SiMo12)组成。采用 FT-IR、XRD、SEM、EDX、TEM、BET 和 TG-DTA 分析技术对合成催化剂的理化性质进行了研究。研究证明,合成的 SiMo12 催化剂能有效地与 Al2O3 表面结合。研究了所制备催化剂在无溶剂条件下通过醛、丙二腈、水合肼和乙酰乙酸乙酯的环缩合反应合成吡喃吡唑(6-氨基-4-苯基-3-甲基-2,4-二氢吡喃并[2,3-c]吡唑-5-甲腈)的催化活性。在不同的催化剂中,以 Al2O3 为载体的 30% SiMo12 的催化活性最高。产率高、反应时间短、操作简单、无溶剂条件和催化剂可重复使用是该方案的显著特点。
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引用次数: 0
Novel annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3,4]thiadiazolo[3,2-a] pyrimidines and chromeno[3'',2'':5',6']pyrido[2',3':4,5]pyrimido[2,1-b][1,3,4] thiadiazines: Synthetic approaches and antimicrobial efficiency 新型环状铬[3',2':5,6]吡啶并[2,3- d ][1,3,4]噻二唑并[3,2- a ]嘧啶和铬[3'',2'':5',6']吡啶并[2',3':4,5]嘧啶并[2,1- b ][1,3,4]噻二嗪:合成方法和抗菌效率
IF 2.1 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-05-18 DOI: 10.1080/00397911.2024.2346565
F. M. Alshareef , Zahra M. Alamshany , Sami A. Al-Harbi , Esam S. Allehyani , Magdy A. Ibrahim

The current study includes synthetic approaches for some linear heterocyclic compounds containing chromone moiety. Chromenopyridopyrimidine bearing amino-thione functions 4 was efficiently synthesized starting from 6,8-dimethylchromone-3-carbonitrile (1). The novel chromenopyridothiadiazolopyrimidines were synthesized through condensation of the key precursor 4 with some mono-electrophilic reagents. In addition, heteroannulated chromenopyridopyrimidothiadiazines were synthesized through condensation of compound 4 with some α-halogenated carbonyl reagents. The synthesized products were examined for their antimicrobial efficiency appearing remarkable activity against the inspected microorganisms especially compounds 7, 12 and 14. The synthesized products were inferred using analytical and spectral data.

目前的研究包括一些含有铬酮分子的线性杂环化合物的合成方法。以 6,8-二甲基铬酮-3-甲腈(1)为起始原料,高效合成了具有氨基硫酮功能的铬并吡啶嘧啶 4。通过将关键前体 4 与一些单亲电试剂缩合,合成了新型铬吡啶噻二唑嘧啶。此外,通过化合物 4 与一些α-卤代羰基试剂缩合,合成了杂化的铬吡啶嘧啶噻二嗪类化合物。对合成产物的抗菌效率进行了检测,结果表明其对受检微生物具有显著的活性,尤其是化合物 7、12 和 14。利用分析和光谱数据对合成产物进行了推断。
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引用次数: 0
An overall development on catalytic applications of potassium phthalimide (PPI) and potassium phthalimide-N-oxyl (POPINO) in organic synthesis 邻苯二甲酰亚胺钾(PPI)和邻苯二甲酰亚胺-N-氧乙基钾(POPINO)在有机合成中的催化应用的总体发展情况
IF 2.1 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-04-24 DOI: 10.1080/00397911.2024.2342316
Urvi J. Khengar , Dharti R. Bhandari , Rajesh H. Vekariya , Jinal A. Gajjar

Potassium phthalimide (PPI) and Potassium phthalimide-N-oxyl (POPINO) have emerged as a versatile and efficient catalyst in various organic synthesis reactions, playing a crucial role in the development of sustainable and environmentally friendly synthetic methodologies. This review highlights the catalytic applications of PPI and POPINO in diverse transformations, showcasing its potential as a valuable tool in modern organic synthesis. The multifaceted reactivity of PPI and POPINO has been explored in reactions such as nucleophilic substitutions, condensations, cycloadditions, and oxidation processes, making it an attractive catalyst for the synthesis of complex organic molecules.

邻苯二甲酰亚胺钾(PPI)和邻苯二甲酰亚胺钾-N-氧(POPINO)已成为各种有机合成反应中用途广泛的高效催化剂,在开发可持续和环境友好型合成方法中发挥着至关重要的作用。本综述重点介绍了 PPI 和 POPINO 在各种转化过程中的催化应用,展示了其作为现代有机合成重要工具的潜力。PPI 和 POPINO 在亲核取代、缩合、环加成和氧化过程等反应中具有多方面的反应活性,使其成为合成复杂有机分子的一种极具吸引力的催化剂。
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引用次数: 0
Asymmetric Diels–Alder reaction of chalcone and isoprene mediated by titanium-based complexes 钛基络合物介导的查尔酮和异戊二烯的不对称 Diels-Alder 反应
IF 2.1 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-04-17 DOI: 10.1080/00397911.2024.2324002
Chun Keng Thy , Yean Kee Lee , Iskandar Abdullah , Noorsaadah Abd Rahman , Chin Fei Chee

The asymmetric Diels–Alder reaction of chalcone and isoprene has been accomplished by use of chiral titanium complexes. Notably, an enantiomeric excess as high as 61% and a regioselectivity of 95% have been achieved. The preparation of the chiral titanium complexes is simple and does not require the pre-installation of a chiral auxiliary. This study represents the first example of asymmetric Diels–Alder reaction between chalcone and isoprene.

利用手性钛络合物完成了查尔酮和异戊二烯的不对称 Diels-Alder 反应。值得注意的是,该反应的对映体过量率高达 61%,区域选择性高达 95% ...
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引用次数: 0
Polyethyleneimine-immobilized CoCl2 nanoparticles: Synthesis, characterization, application as a new efficient and reusable nanocomposite catalyst for one-step transesterification reaction 聚乙烯亚胺固定的 CoCl2 纳米颗粒:一步法酯交换反应的新型高效可重复使用纳米复合催化剂的合成、表征和应用
IF 2.1 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-04-17 DOI: 10.1080/00397911.2024.2328287
Tahereh Darvishi , Sedigheh Azadi , Nooredin Goudarzian

Polyethyleneimine-supported cobalt (II) chloride as a novel polymeric nanocomposite acidic catalyst for the one-stage transesterification reaction of ethyl acetate with various alcohols is reported. The catalyst was characterized by Fourier transform infrared spectroscopy, X-ray powder diffraction, transmission electron microscopy, scanning electron microscopy, dynamic light scattering technique, and thermal gravimetric analysis. Furthermore, inductively coupled plasma and atomic absorption spectroscopy were used to determine the quantity of Cobalt nanoparticles in the catalyst. By adding the catalyst (0.10 g, 0.20 mol%) and n-hexane/chloroform (5.0 cm3) as solvent under reflux conditions, the studies demonstrated successful transesterification reactions with excellent yields (80–98%) and short reaction times (0.50–1.30 h) using various substrates on the scale of 1.0 mmol. Seven consecutive reactions could be performed on the catalyst without significantly decreasing its activity. The most noteworthy aspects of this process are its low cost, safety, and environmental friendliness due to the catalyst’s non-toxicity, straightforward operation, and effective outcomes.

报道了聚乙烯亚胺支撑的氯化钴 (II) 作为一种新型聚合物纳米复合酸性催化剂,用于乙酸乙酯与各种醇的一段式酯交换反应...
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引用次数: 0
Synthesis of 1H-benzimidazoles via the condensation of o-phenylenediamines with DMF promoted by organic acid under microwave irradiation 微波辐照下有机酸促进邻苯二胺与 DMF 缩合合成 1H 苯并咪唑
IF 2.1 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-04-17 DOI: 10.1080/00397911.2024.2324456
Wenjuan Li , Xiao Li , Hailong Hong , Ruijun Xie , Ning Zhu

An effective, green and eco-friendly method was developed to synthesize 1H-benzimidazole under microwave irradiation. The reactions of substituted o-phenylenediamine with DMF were efficiently promoted by butanoic acid, and the desired product 1H-benzimidazole derivatives were obtained in good to excellent yields. Compared with the conventional heating method, microwave irradiation significantly reduced the reaction time and improved the yields of the target products.

开发了一种在微波辐照下合成 1H-苯并咪唑的有效、绿色和环保方法。取代的邻苯二胺与DMF的反应能有效地促进1H-苯并咪唑的合成。
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引用次数: 0
Novel pyrano[2,3-c]pyrazolopyrimidines as promising anticancer agents: Design, synthesis, and cell cycle arrest of HepG2 cells at S phase 新型吡喃并[2,3-c]吡唑嘧啶作为有前途的抗癌剂:设计、合成和抑制 S 期 HepG2 细胞的细胞周期
IF 2.1 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-04-17 DOI: 10.1080/00397911.2024.2327047
David S. A. Haneen , Mohamed H. Hekal , Wael S. I. Abou-Elmagd , Wael M. El-Sayed

The poor selectivity, significant toxicity, high cost, and emergence of resistance of conventional chemotherapies are driving motive for the ongoing search for novel anticancer agents. New pyrano[2,3-c]pyrazolopyrimidines were synthesized and examined as antiproliferative agents, and the possible molecular mechanism(s) of action were explored. The mass and elemental analyses, alongside the IR,1H, and 13C NMR spectra, confirmed the proposed structures of the obtained compounds. Derivatives 4 and 7 demonstrated the best antiproliferative profile against HepG2 cancer cells at 4 µM, with a high selectivity index of ∼7–9 folds. They increased the S phase cell population by 51% and 40% and caused a 5- and 11-fold increase in the p21 protein. Compound 7 was superior in inhibiting HepG2 cell migration and delayed wound healing, reducing migration rates by 55% and 90%, respectively. Future studies on the pharmacokinetics, pharmacodynamics, antimetastatic, and antitumor activities in animal models would be a robust advance.

传统化疗药物选择性差、毒性大、成本高、抗药性强,这些都是目前寻找新型抗癌药物的动力。新型吡喃并[2...
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引用次数: 0
Review of synthesis process of benzimidazole-heterocycle hybrid compounds 苯并咪唑杂环化合物合成工艺综述
IF 2.1 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-04-17 DOI: 10.1080/00397911.2024.2316718
Abouelhaoul El Alami , Hamid Sdassi , Said Bouzikri

Over the last few years, benzimidazole-heterocycle hybrid compounds have received considerable attention due to the wide spectrum of their biological property and many important chemical and pharmacological applications. These compounds have revealed antibacterial, antimicrobial, anticoagulant, antidiabetic and other activities, and they have been used as drugs in the market to treat several diseases. Furthermore, hybrid heterocyclic compounds possessing a benzimidazole skeleton exhibit significant complexing and anticorrosive properties. All of these applications have favored the development of a large number of synthetic strategies to prepare these heterocyclic systems in different reaction conditions. Many research articles on the synthesis of benzimidazole-heterocycle hybrid compounds have been reported in the literature. In this review, we present and discuss the synthetic routes of several benzimidazole-heterocycle hybrid compounds.

在过去几年中,苯并咪唑-杂环杂化化合物因其广泛的生物特性和许多重要的化学和医药用途而受到广泛关注。
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引用次数: 0
The Lacunae identified in processing, analyzing and finding means of catalyst free Oxone mediated through C-3 oxidation of N-alkyl quinoxalin-2(1h)-one 在处理、分析和寻找通过 C-3 氧化 N-烷基喹喔啉-2(1h)-酮介导的无催化剂 Oxone 的方法过程中发现的缺陷
IF 2.1 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-04-17 DOI: 10.1080/00397911.2024.2329245
Vikas S. Patil , Gayathri Chunduri , Balaram Kiran Avasarala , Gangaiah L , Pasham Yoganand , Kola Srinivas , Murali Koparala , Nagaraju Devunuri

A catalyst free oxone mediated synthesizing N-alkyl 1, 4-dihydroquinoxaline-2,3-dione has been developed by oxidation of the N-alkyl quinoxalin-2(1H)-one. The developed method is a novel, safest, cost-effective, industrially viable method and applicable for N-substituted and without substitution of 1,4-dihydroquinoxaline-2,3-dione. Consequently, the process is applicable to a broad spectrum of functionality. The reaction can be performed in all organic solvents without any further heating with an extended time and without generating side products. This novel synthetic methodology using Oxone is believed to be the shortest and most efficient to prepare various key intermediates which can be used for further derivatization to make the different biologically active molecules, the key feature of this methodology is not solvent specific, all organic solvents giving the optimum purity and quality using the same reaction condition.

通过氧化 N-烷基喹喔啉-2(1H)-酮,开发了一种无催化剂氧化酮介导合成 N-烷基 1,4-二氢喹喔啉-2,3-二酮的方法。所开发的方法是一种新颖、安全、简便的合成方法。
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引用次数: 0
KHSO4 promoted practical synthesis of quinazolin-4(3H)-ones and benzothiadiazine 1,1-dioxides KHSO4 促进喹唑啉-4(3H)-酮和苯并噻二嗪 1,1-二氧化物的实用合成
IF 2.1 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-04-04 DOI: 10.1080/00397911.2024.2335638
Jiecheng Zheng , Feng Gong , Wei Wang , Yue Wu , Dezhang Zhao , Tianyuan Zhang , WenWen Yang , Zongjie Gan

A broad scope of quinazolin-4(3H)-ones or benzothiadiazine 1,1-dioxides was obtained via a transition-metal free and convenient method. This approach involving KHSO4 promoted cyclization and dehydration between diverse functionalized 2-aminobenzamides or 2-aminobenzenesulfonamides and N, N-dimethylformamide derivatives. The protocol offers moderate to excellent yields (45%-93%) under mild condition in a short of reaction time of 6 hours. The use of an environment-friendly and less expensive catalyst KHSO4 also makes this protocol more attractive.

通过一种不含过渡金属的便捷方法,获得了范围广泛的喹唑啉-4(3H)-酮或苯并噻二嗪-1,1-二氧杂环。这种方法涉及 KHSO4,促进了多种官能化 2-氨基苯甲酰胺或 2-氨基苯磺酰胺与 N,N-二甲基甲酰胺衍生物之间的环化和脱水。该方案在温和的条件下,只需 6 小时的反应时间,就能获得中等到极好的产率(45%-93%)。使用环保且价格较低的催化剂 KHSO4 也使该方案更具吸引力。
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引用次数: 0
期刊
Synthetic Communications
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