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Synthesis of thiazolidinone and methylthiazole derivatives incorporating benzodioxole moiety and evaluation of their antimicrobial activity 合成含有苯并二恶茂分子的噻唑烷酮和甲基噻唑衍生物并评估其抗菌活性
IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-17 DOI: 10.1080/00397911.2024.2387118

One of the most serious future challenges to health care professionals is the emergence of multi-drug resistance pathogenic microbes that rapidly develop resistance to currently used antibiotics. So, as a way to overcome the antimicrobial drug-resistance problems, it is urgent need to synthesize several new lead molecules that are expected to have antibacterial and antifungal activities. So, some new thiazolidinone and methylthiazole derivatives incorporating benzodioxole nucleolus were constructed. Two different series of N-substituted thiosemicarbazones carrying a benzodioxole nucleus were synthesized through mutation reaction of the different aromatic and heterocyclic aldehydes with benzodioxolyl thiosemicarbazide. Cycloalkylation reaction of the latter thiosemicarbazones through with both of the ethyl chloroacetate or chloroacetone gave the thiazolidin-4-ones or 4-methylthiazoles, respectively. The antimicrobial activity of the thiazolidin-4-one and 4-methylthiazole derivatives was investigated. All of compounds showed from weak to moderate effects toward all tested bacteria.

未来,医疗保健专业人员面临的最严峻挑战之一,就是出现对目前使用的抗生素迅速产生耐药性的多重抗药性病原微生物。因此,作为克服抗菌药耐药性问题的一种方法,迫切需要合成几种有望具有抗菌和抗真菌活性的新先导分子。因此,我们合成了一些含有苯并二噁唑核醇的新噻唑烷酮和甲基噻唑衍生物。通过不同的芳香族和杂环醛与苯并二氧戊环硫代氨基脲的突变反应,合成了两个不同系列的N-取代的带苯并二氧戊环核的硫代氨基脲。这些硫代氨基羰基化合物与氯乙酸乙酯或氯丙酮发生环烷基化反应,分别生成了噻唑烷-4-酮或 4-甲基噻唑。研究了噻唑烷-4-酮和 4-甲基噻唑衍生物的抗菌活性。所有化合物对所有受试细菌都显示出弱到中等程度的作用。
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引用次数: 0
Synthesis of novel chromenyl phosphonates via nano-ZnO-catalyzed microwave method: Exploring potential anti-diabetic agents through molecular docking, ADMET analysis, and α-amylase inhibition 通过纳米氧化锌催化微波法合成新型铬烯基膦酸盐:通过分子对接、ADMET 分析和 α 淀粉酶抑制作用探索潜在的抗糖尿病药物
IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-14 DOI: 10.1080/00397911.2024.2388799

A more efficient and environmentally friendly approach has been developed for synthesizing phosphonates through the Michaelis-Arbuzov reaction, catalyzed by nano-ZnO in a solvent-free environment, utilizing microwave irradiation. Before synthesis, each compound underwent in silico ADMET analysis and molecular docking to assess drug-like characteristics and their potential to inhibit α-amylase. The structure of the newly synthesized compounds was validated using spectroscopic analysis, and their in vitro inhibitory effects on α-amylase were assessed. Among the compounds, dimethyl 2-(anthracen-10-yl)-4-oxo-4H-chromen-6-yl-6-phosphonate (6j), dimethyl 2-(naphthalen-1-yl)-4-oxo-4H-chromen-6-yl-6-phosphonate (6h), and dimethyl 2-(1-methyl-1H-indol-3-yl)-4-oxo-4H-chromen-6-yl-6-phosphonate (6e) displayed the highest inhibitory activity compared to the reference substance, acarbose. Additionally, compounds dimethyl 2-(benzo[d][1,3]dioxol-4-yl)-4-oxo-4H-chromen-6-yl-6-phosphonate (6i), dimethyl 4-oxo-2-phenyl-4H-chromen-6-yl-6-phosphonate (6a), and dimethyl 2-(1H-indol-5-yl)-4-oxo-4H-chromen-6-yl-6-phosphonate (6g) exhibited nearly equivalent effective inhibitory activity when compared to the standard. The remaining compounds demonstrated moderate to good enzyme inhibition.

在无溶剂环境中,利用微波辐照,在纳米氧化锌催化下,通过迈克尔斯-阿尔布佐夫反应合成膦酸盐,开发出了一种更高效、更环保的方法。在合成之前,每个化合物都经过了硅学 ADMET 分析和分子对接,以评估其类似药物的特性及其抑制 α 淀粉酶的潜力。利用光谱分析验证了新合成化合物的结构,并评估了它们对α-淀粉酶的体外抑制作用。和 2-(1-甲基-1H-吲哚-3-基)-4-氧代-4H-苯并吡喃-6-基-6-膦酸二甲酯(6e)与参照物阿卡波糖相比显示出最高的抑制活性。此外,化合物 2-(苯并[d][1,3]二恶茂-4-基)-4-氧代-4H-苯并吡喃-6-基-6-膦酸二甲酯(6i)、4-氧代-2-苯基-4H-苯并吡喃-6-基-6-膦酸二甲酯(6a)和 2-(1H-苯并[d][1,3]二恶茂-4-基)-4-氧代-4H-苯并吡喃-6-基-6-膦酸二甲酯(6b和 2-(1H-吲哚-5-基)-4-氧代-4H-苯并吡喃-6-基-6-膦酸二甲酯(6g)与标准化合物相比,表现出几乎相同的有效抑制活性。其余化合物表现出中等到良好的酶抑制作用。
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引用次数: 0
Synthetic approaches for quinoline heterocycles fused at face b: A review 面 b 融合的喹啉杂环的合成方法:综述
IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-14 DOI: 10.1080/00397911.2024.2390172

Quinolines are very important materials in organic synthesis due to their wide range of biological activities as well as representing one of the most research area in medicinal chemistry. Quinolines have many applications in design and synthesis of multiple heterocyclic compounds with a wide variety of biological significance. Quinolines fused heterocycles at face b using different synthetic methodologies as well as variable precursors and reaction conditions were the aim of the current review.

喹啉类化合物具有广泛的生物活性,是有机合成中非常重要的材料,也是药物化学研究领域中最重要的材料之一。喹啉类化合物在设计和合成多种具有广泛生物学意义的杂环化合物方面有很多应用。本综述的目的是利用不同的合成方法以及可变的前体和反应条件,在 b 面融合喹啉杂环。
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引用次数: 0
Synthesis of N-(1-((1H-perimidin-2-yl)amino)-2,2,2-trichloroethyl)carboxamides based on N-(2,2,2-trichloro-1-isothiocyanatoethyl)carboxamides 以 N-(2,2,2-三氯-1-异硫氰乙基)羧酰胺为基础合成 N-(1-((1H-哌啶-2-基)氨基)-2,2,2-三氯乙基)羧酰胺
IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-12 DOI: 10.1080/00397911.2024.2390178

Here we report the development of a concise and efficient synthetic protocol for the preparation of 1H-perimidin-2-amine derivatives that contain an N-(2,2,2-trichloroethyl)carboxamide substituent near the amino group. These compounds’ synthesis method is based on the interaction of naphthalene-1,8-diamine with N-(2,2,2-trichloro-1-isothiocyanatoethyl)carboxamides under reflux in acetonitrile medium for 15 minutes. This transformation is likely to pass through the stage of formation of the intermediate thiourea, which further eliminates hydrogen sulfide, which is accompanied by the closure of the perimidine cycle. Using the developed protocol, we synthesized nine new 1H-perimidin-2-amine derivatives. The yield of synthesized compounds was 67-82%. IR,1H NMR,13C NMR, 1H-1H COSY, 1H-13C HSQC, and 1H-13C HMBC spectroscopy data proved their structures.

我们在此报告了一种简洁高效的合成方案,用于制备在氨基附近含有 N-(2,2,2-三氯乙基)羧酰胺取代基的 1H-perimidin-2-amine 衍生物。这些化合物的合成方法基于萘-1,8-二胺与 N-(2,2,2-三氯-1-异硫氰乙基)羧酰胺在乙腈介质中回流 15 分钟后的相互作用。这种转化很可能要经过中间体硫脲的形成阶段,硫脲进一步消除硫化氢,伴随着包嘧啶循环的关闭。利用所开发的方案,我们合成了九种新的 1H-perimidin-2-amine 衍生物。合成化合物的收率为 67-82%。红外光谱、1H NMR、13C NMR、1H-1H COSY、1H-13C HSQC 和 1H-13C HMBC 光谱数据证明了它们的结构。
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引用次数: 0
One pot synthesis of 4-iodo-3-phenylbenzo[b][1,6]naphthyridine via imino iodization-cyclization of alkynylquinoline-3-carbaldehydes 通过炔基喹啉-3-羰基醛的亚氨基碘化-环化一次性合成 4-碘-3-苯基苯并[b][1,6]萘啶
IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-12 DOI: 10.1080/00397911.2024.2389542

Simple, environmentally benign and metal free one pot strategy has been used for the synthesis of 4-iodo-3-phenylbenzo[b][1,6]naphthyridine from O-alkynylquinolinyl aldehydes with tert-butyl amine and iodine through imine formation in good to excellent yield at room temperature in aerobic and mild conditions. The beauty of this reaction is the imine formation and cyclization in the same reaction pot. Due to presence of iodine in product, it can be useful for further reaction and can be valuable synthon for new organic compounds.

在室温、有氧和温和的条件下,采用简单、环保和无金属的一锅法从 O-炔基喹啉基醛与叔丁胺和碘通过亚胺的形成合成了 4-碘-3-苯基苯并[b][1,6]萘啶,收率良好甚至极佳。该反应的美妙之处在于亚胺的形成和环化在同一反应釜中完成。由于产物中含有碘,它可用于进一步反应,并可作为新有机化合物的重要合成物。
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引用次数: 0
Synthesis of trifluoromethyl substituted heterocyclic compounds with β-trifluoromethylated acrylates 用 β-三氟甲基丙烯酸酯合成三氟甲基取代的杂环化合物
IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-10 DOI: 10.1080/00397911.2024.2390696
Trifluoromethyl heterocyclic compounds have high lipophilicity, metabolic stability and binding selectivity, so it is very important to develop their synthetic methods. This review provides an overview of synthesis of trifluoromethyl substituted heterocyclic compounds from β-trifluoromethylated acrylates over the period from 2018 to the present.
三氟甲基杂环化合物具有很高的亲脂性、代谢稳定性和结合选择性,因此开发其合成方法非常重要。本综述介绍了...
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引用次数: 0
Synthesis, antiproliferative activity and insilco studies of substituted 2-((N-benzyl-5-bromo-2-methoxyphenyl) sulfonamide) glycinamide derivatives 取代的 2-((N-苄基-5-溴-2-甲氧基苯基)磺酰胺)甘氨酰胺衍生物的合成、抗增殖活性和绝缘研究
IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-06 DOI: 10.1080/00397911.2024.2387810

The present work aimed to synthesize different substituted glycinamide derivatives. A series of novel substituted 2-((N-benzyl-5-bromo-2-methoxyphenyl) sulfonamide) and their glycinamide derivatives (5a–5p) were synthesized. We developed a simple strategy for synthesizing functionally diverse sulfonamide and glycinamide derivatives through a series of steps. A series of molecules containing amide derivatives were designed and synthesized, and their structures were elucidated and confirmed by1H NMR, 13 C NMR, LCMS, and their purity was checked using HPLC. The synthesized compounds were screened for anticancer activity against A-549 and A431 cancer cell lines by MTT assay and then docking studies were carried out to understand the molecular interactions. The preliminary bioassay suggests that most compounds showed remarkable anti-proliferation activity. Gefitinib was used as a positive control. The compounds 5g and 5f were active compared with Gefitinib in both the cell lines.

本研究旨在合成不同的取代甘氨酰胺衍生物。我们合成了一系列新型取代的 2-((N-苄基-5-溴-2-甲氧基苯基)磺酰胺)及其甘氨酰胺衍生物(5a-5p)。我们开发了一种简单的策略,通过一系列步骤合成功能多样的磺酰胺和甘氨酰胺衍生物。我们设计并合成了一系列含有酰胺衍生物的分子,并通过 1H NMR、13 C NMR 和 LCMS 对其结构进行了阐明和确认,同时使用 HPLC 对其纯度进行了检测。通过 MTT 试验筛选了合成的化合物对 A-549 和 A431 癌细胞株的抗癌活性,然后进行了对接研究以了解分子间的相互作用。初步生物测定表明,大多数化合物具有显著的抗癌活性。吉非替尼被用作阳性对照。与吉非替尼相比,化合物 5g 和 5f 在两种细胞系中都具有活性。
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引用次数: 0
Nucleophilic reactions with 3-formylchromones: A decade update 与 3-甲酰基色素的亲核反应:十年更新
IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-05 DOI: 10.1080/00397911.2024.2387134

The chemical reactivity of 3-formylchromones toward several carbon and nitrogen nucleophiles is collected in this review. Certain annulated chromones and 3-heteroaryl chromones were synthesized. A diversity of three component reactions including 3-formylchromones was also summarized.

本综述收集了 3-甲酰基色酮对几种碳和氮亲核物的化学反应性。本综述收集了 3-甲酰基色原酮与几种碳氮亲核物的化学反应性,并合成了某些环状色原酮和 3-异芳基色原酮。还总结了包括 3-甲酰基色原酮在内的三组分反应的多样性。
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引用次数: 0
TBAB-catalyzed assisted C-C/C-N bond formations: An efficient approach to dihydrobenzo[b][1,8]naphthyridin derivatives via metal free Cascade annulation TBAB 催化辅助 C-C/C-N 键形成:通过无金属级联环化获得二氢苯并[b][1,8]萘啶衍生物的有效方法
IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-02 DOI: 10.1080/00397911.2024.2379447

An eco-friendly, metal-free approach for synthesizing dihydrobenzo[b][1,8]naphthyridine derivatives has been established. This method employs ortho-chloroquinolin-α,β-unsaturated ketones as dipolarophiles and acyclic enaminones as amphiphilic nucleophiles, enabling a formal [3 + 3] annulation reaction under phase-transfer catalysis to offed the targeted products. It boasts transition-metal-free conditions, broad functional group compatibility, and straightforward operational procedures.

合成二氢苯并[b][1,8]萘啶衍生物的环保型无金属方法已经建立。该方法采用正交-氯喹啉-α,β-不饱和酮作为双极性...
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引用次数: 0
1,4,5,8-tetrasubstituted dihydroanthracene-based triptycene trisquinones: Synthesis, structural, and physicochemical characterization 1,4,5,8-四取代二氢蒽基三庚烯三醌:合成、结构和理化特性分析
IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-02 DOI: 10.1080/00397911.2024.2381074

1,4,5,8-tetrasubstituted dihyroanthracene-based triptycene trisquinones (TT) molecules, THAO-TT and tris(THAO)-TT, were synthesized by Diels–Alder reaction between TT and 1,4,5,8-tetrakis(hexyloxy)anthracene to produce the extended triptycene derivatives containing electron-accepting functionality. The prepared THOA-TT and tris(THOA)-TT exhibited excellent thermal stability owing to the rigid TT framework. The optical and redox properties of THOA-TT and tris(THOA)-TT were controlled by the homoconjugation between the benzoquinone units and the peripheral units through the connecting methine groups.

通过 TT 与 1,4,5,8-四(己氧基)蒽之间的 Diels-Alder 反应合成了 1,4,5,8-四取代二氢蒽基三庚烯三醌(TT)分子 THAO-TT 和 tris(THAO)-TT,从而制备出含有电子接受官能团的扩展三庚烯衍生物。制备的 THOA-TT 和三(THOA)-TT 具有良好的热稳定性,这得益于 TT 的刚性框架。THOA-TT 和三(THOA)-TT 的光学和氧化还原特性由苯醌单元和外围单元之间通过连接的甲基进行的同共轭控制。
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引用次数: 0
期刊
Synthetic Communications
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