The chlorination of 5-thioxo-10,11-dihydro-5 H -dibenzo[ a,d ]cycloheptene 2a gave 5-chloro-10,11-dihydro-5 H -dibenzo[ a,d ]cycloheptene-5,10-sulfide 4 . Chlorination of 5-thioxo-5 H -dibenzo[ a,d ]cycloheptene 2b gave the two isomers cis - and trans -5,11-dichloro-10,11-dihydro-5 H -dibenzo[ a,d ]cycloheptene-5,10-sulfide 7a,b . The two sulfides 4 and 7a,b were oxidized by using mCPBA or H 2 O 2 /AcOH to give the corresponding sulfoxides 5 and 8a,b , respectively. Treatment of the sulfide 7a,b with KI gave the primary ketone 1b together with trans -5-chloro-11-hydroxy-10,11-dihydro-5 H -dibenzo[ a,d ]cycloheptene-5,10-sulfide 9 . The structures of the new compounds were established by different spectroscopic techniques as well as single crystal X-ray diffraction for compounds 4 and 9 .
5-硫氧基-10,11-二氢-5 H -二苯并[a,d]环庚烯2a氯化得到5-氯-10,11-二氢-5 H -二苯并[a,d]环庚烯-5,10-硫4。氯化5-硫氧基-5 H -二苯并[a,d]环庚烯2b得到顺式和反式两种异构体-5,11-二氯-10,11-二氢-5 H -二苯并[a,d]环庚烯-5,10-硫7a,b。两种硫化物4和7a,b分别用mCPBA或h2o2 /AcOH氧化得到相应的亚砜5和8a,b。硫化物7a,b用KI处理得到伯酮1b和反式-5-氯-11-羟基-10,11-二氢-5- H -二苯并[a,d]环庚烯-5,10-硫化物9。通过不同的光谱技术以及化合物4和9的单晶x射线衍射确定了新化合物的结构。
{"title":"Synthesis of 5-Chloro-10,11-Dihydro-5 H -Dibenzo[ a , d ]Cycloheptene-5,10-Sulfide and -5,11-Dichloro-10,11-Dihydro-5 H -Dibenzo[ A , D ]Cycloheptene-5,10-Sulfide and their Oxidation","authors":"M. Hegab, A. El-Gazzar, I. Farag, F. A. Gad","doi":"10.1080/02786110211428","DOIUrl":"https://doi.org/10.1080/02786110211428","url":null,"abstract":"The chlorination of 5-thioxo-10,11-dihydro-5 H -dibenzo[ a,d ]cycloheptene 2a gave 5-chloro-10,11-dihydro-5 H -dibenzo[ a,d ]cycloheptene-5,10-sulfide 4 . Chlorination of 5-thioxo-5 H -dibenzo[ a,d ]cycloheptene 2b gave the two isomers cis - and trans -5,11-dichloro-10,11-dihydro-5 H -dibenzo[ a,d ]cycloheptene-5,10-sulfide 7a,b . The two sulfides 4 and 7a,b were oxidized by using mCPBA or H 2 O 2 /AcOH to give the corresponding sulfoxides 5 and 8a,b , respectively. Treatment of the sulfide 7a,b with KI gave the primary ketone 1b together with trans -5-chloro-11-hydroxy-10,11-dihydro-5 H -dibenzo[ a,d ]cycloheptene-5,10-sulfide 9 . The structures of the new compounds were established by different spectroscopic techniques as well as single crystal X-ray diffraction for compounds 4 and 9 .","PeriodicalId":22122,"journal":{"name":"Sulfur Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78621581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper describes the facile and selective oxidation of sulfides 1 and thiols 3 to their corresponding sulfoxides 2 and disulfides 4 with potassium permanganate supported on alumina in high yields under solvent-free conditions.
{"title":"A facile and selective method for oxidation of sulfides and thiols to their corresponding sulfoxides and disulfides with alumina-supported potassium permanganate under solvent-free conditions","authors":"A. Hajipour, S. Mallakpour, H. Adibi","doi":"10.1080/02786110213976","DOIUrl":"https://doi.org/10.1080/02786110213976","url":null,"abstract":"This paper describes the facile and selective oxidation of sulfides 1 and thiols 3 to their corresponding sulfoxides 2 and disulfides 4 with potassium permanganate supported on alumina in high yields under solvent-free conditions.","PeriodicalId":22122,"journal":{"name":"Sulfur Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85543765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S , S '-Dialkyl N -(arenesulfonyl)carbondithioimidates 3 are prepared either in a one-pot reaction by successive alkylation of disodium salts 2 or by using N -(arenesulfonyl)dithiocarbamates 4 . C,H-Acidic N -(arenesulfonyl)-carbondithioimidates 3a , b , d react with thiacumulenes in the presence of sodium hydride. Subsequent methylation leads to 2,3-dihydrothiazoles 7 and 1,3-dithiols 8 , respectively.
S, S '-二烷基N -(芳烃磺酰基)二硫代氨基甲酸酯可以通过二钠盐的连续烷基化在一锅反应中制备，也可以用N -(芳烃磺酰基)二硫代氨基甲酸酯4制备。C, h -酸性N -(arenesulfonyl)-碳二硫代酸盐3a, b, d在氢化钠存在下与噻唑烯反应。随后的甲基化分别生成2,3-二氢噻唑7和1,3-二硫醇8。
{"title":"Synthesis and Reactivity of Unsymmetrical S , S ″ -Dialkyl N -(Arenesulfonyl)Carbondithioimidates","authors":"W. Rudolf, D. Cleve, A. Riemer","doi":"10.1080/02786110210630","DOIUrl":"https://doi.org/10.1080/02786110210630","url":null,"abstract":"S , S '-Dialkyl N -(arenesulfonyl)carbondithioimidates 3 are prepared either in a one-pot reaction by successive alkylation of disodium salts 2 or by using N -(arenesulfonyl)dithiocarbamates 4 . C,H-Acidic N -(arenesulfonyl)-carbondithioimidates 3a , b , d react with thiacumulenes in the presence of sodium hydride. Subsequent methylation leads to 2,3-dihydrothiazoles 7 and 1,3-dithiols 8 , respectively.","PeriodicalId":22122,"journal":{"name":"Sulfur Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79838512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. El-Desoky, H. Etman, S. Bondock, A. Fadda, M. Metwally
Reaction of substituted pyrazolin-5-one and 3-phenyl-5-isoxazolone 1a-c with phenyl isothiocyanate in basic DMF gave the non-isolable sodium salt of the adduct 2a-c which was treated with HCl to give the corresponding thiocarbamoyl derivatives 3a-c . The latter compounds underwent heterocyclization upon treatment with chloroacetyl chloride and ethyl bromoacetate to give the corresponding thiazolidinone derivatives 6 and 7 . Compound 3a,b was oxidized to yield benzothiazoly pyrazolinone derivatives 8a,b . Also, nucleophilic substitution of 2 and 3 and with different nucleophilic reagents afforded the products 9-14 . Cyclocondensation of the thiocarbamoyl salt with some halogenated esters or acid chloride derivatives such as f -bromopropionate, ethyl chloroformate and f -bromo diethyl malonate afforded cyclized polyfunctionally thiazinone, thiazetidinone and thiazolidinone derivatives respectively 15-17 . The structures of the products were confirmed by spectral and micro analytical data.
{"title":"Utility of isothiocyanates in heterocyclic synthesis","authors":"S. El-Desoky, H. Etman, S. Bondock, A. Fadda, M. Metwally","doi":"10.1080/02786110214496","DOIUrl":"https://doi.org/10.1080/02786110214496","url":null,"abstract":"Reaction of substituted pyrazolin-5-one and 3-phenyl-5-isoxazolone 1a-c with phenyl isothiocyanate in basic DMF gave the non-isolable sodium salt of the adduct 2a-c which was treated with HCl to give the corresponding thiocarbamoyl derivatives 3a-c . The latter compounds underwent heterocyclization upon treatment with chloroacetyl chloride and ethyl bromoacetate to give the corresponding thiazolidinone derivatives 6 and 7 . Compound 3a,b was oxidized to yield benzothiazoly pyrazolinone derivatives 8a,b . Also, nucleophilic substitution of 2 and 3 and with different nucleophilic reagents afforded the products 9-14 . Cyclocondensation of the thiocarbamoyl salt with some halogenated esters or acid chloride derivatives such as f -bromopropionate, ethyl chloroformate and f -bromo diethyl malonate afforded cyclized polyfunctionally thiazinone, thiazetidinone and thiazolidinone derivatives respectively 15-17 . The structures of the products were confirmed by spectral and micro analytical data.","PeriodicalId":22122,"journal":{"name":"Sulfur Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88625443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. А. Dorofeev, A. Mal’kina, L. M. Sinegovskaya, B. Trofimov
The interaction of 5,5-dialkyl-4-cyanomethylene-1,3-oxathiolan-2-ones with diethylamine (without catalyst), aliphatic alcohols and ethanethiol (in the presence of triethylamine) occurs under mild conditions (room temperature, 3-12 r h) with ring opening and the subsequent dimerization to give polyfunctional 1,3-dithiolanes.
5,5-二烷基-4-氰乙基-1,3-氧噻吩-2- 1与二乙胺(无催化剂)、脂肪醇和乙硫醇(在三乙胺存在下)的相互作用在温和条件下(室温，3-12 r h)发生，开环和随后的二聚化得到多官能团1,3-二硫代烷。
{"title":"Polyfunctional 1,3-Dithiolanes from 5,5-Dialkyl-4-Cyanomethylene-1,3-Oxathiolan-2-Ones","authors":"I. А. Dorofeev, A. Mal’kina, L. M. Sinegovskaya, B. Trofimov","doi":"10.1080/02786110210634","DOIUrl":"https://doi.org/10.1080/02786110210634","url":null,"abstract":"The interaction of 5,5-dialkyl-4-cyanomethylene-1,3-oxathiolan-2-ones with diethylamine (without catalyst), aliphatic alcohols and ethanethiol (in the presence of triethylamine) occurs under mild conditions (room temperature, 3-12 r h) with ring opening and the subsequent dimerization to give polyfunctional 1,3-dithiolanes.","PeriodicalId":22122,"journal":{"name":"Sulfur Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83655344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Trofimov, E. Deryagina, Emma Sukhomazova, E. Levanova, G. Myachina, S. Korzhova, Yuriy V. Mikhaylik, T. Skotheim
Poly(methylene diselenide), -[-CH2Se2-] n -, when alloyed with sulfur in a 1-4 molar excess of the latter, gives dark orange rubber-like poly(methylene seleno-polysulfido-selenides), -[-CH2SeS m Se-] n -, where m =1-4 representing a new class of S-Se organic polymers having no C-S bonds. At molar ratio sulfur:poly(methylene diselenide) equal to 16 sulfur content does not exceed m =4. The selenium part of the polymer, while alloying with sulfur, is removed from the polymer and forms the compound with sulfur. The polymers demonstrate reversible redox properties and can be employed as active cathode materials in rechargeable lithium cells.
聚(亚甲基二硒化物)，-[- ch2se2 -] n -，当与1-4摩尔过量的硫(后者)合金时，得到深橙色的橡胶状聚(亚甲基硒-聚硫-硒化物)，-[- ch2ses m Se-] n -，其中m =1-4代表了一类新的没有C-S键的S-Se有机聚合物。在硫与聚亚甲基二烯的摩尔比等于16时，硫含量不超过m =4。聚合物的硒部分在与硫合金化时，从聚合物中除去并与硫形成化合物。该聚合物具有可逆氧化还原特性，可作为可充电锂电池的活性正极材料。
{"title":"Poly(methylene diselenide) and poly(methylene seleno-polysulfido-selenides), -[-CH2Se2-] n -, -[-CH2SeS m Se-] n -","authors":"B. Trofimov, E. Deryagina, Emma Sukhomazova, E. Levanova, G. Myachina, S. Korzhova, Yuriy V. Mikhaylik, T. Skotheim","doi":"10.1080/02786110214498","DOIUrl":"https://doi.org/10.1080/02786110214498","url":null,"abstract":"Poly(methylene diselenide), -[-CH2Se2-] n -, when alloyed with sulfur in a 1-4 molar excess of the latter, gives dark orange rubber-like poly(methylene seleno-polysulfido-selenides), -[-CH2SeS m Se-] n -, where m =1-4 representing a new class of S-Se organic polymers having no C-S bonds. At molar ratio sulfur:poly(methylene diselenide) equal to 16 sulfur content does not exceed m =4. The selenium part of the polymer, while alloying with sulfur, is removed from the polymer and forms the compound with sulfur. The polymers demonstrate reversible redox properties and can be employed as active cathode materials in rechargeable lithium cells.","PeriodicalId":22122,"journal":{"name":"Sulfur Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75295651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cycloaddition of 1-aza-2-azoniaallene salts ( 2 , 9 and 17 ) with isothiocyanates gave different types of 1,2,4-triazolium salts ( 5 , 6 and 25-34 ), and 1,3,4-thiadiazolium salts ( 12 , 14 and 19 ). The obtained products depend on: a) the ability of a substituent of the heteroallene salts to undergo a [1,2] shift as a cationic charged migrant or to act as a cationic leaving groups (as a stable carbenium ion), b) Dimroth rearrangement of the initially formed thiadiazolium salts to triazolium salts. Accordingly, 1-aza-2-azoniaallenes ( 22 and 29 ) reacted with nitriles and dinitriles to give 1,2,4-triazolium salts ( 25 , 27 and 32-34 ).
{"title":"Further Studies and Synthesis of Five-membered Rings via 1,3-Dipolar Cycloaddition of 1-Aza-2-azoniaallene Cations to Isothiocyanates and Nitriles","authors":"A. El-Gazzar, M. Hegab, N. A. Hassan","doi":"10.1080/02786110211429","DOIUrl":"https://doi.org/10.1080/02786110211429","url":null,"abstract":"Cycloaddition of 1-aza-2-azoniaallene salts ( 2 , 9 and 17 ) with isothiocyanates gave different types of 1,2,4-triazolium salts ( 5 , 6 and 25-34 ), and 1,3,4-thiadiazolium salts ( 12 , 14 and 19 ). The obtained products depend on: a) the ability of a substituent of the heteroallene salts to undergo a [1,2] shift as a cationic charged migrant or to act as a cationic leaving groups (as a stable carbenium ion), b) Dimroth rearrangement of the initially formed thiadiazolium salts to triazolium salts. Accordingly, 1-aza-2-azoniaallenes ( 22 and 29 ) reacted with nitriles and dinitriles to give 1,2,4-triazolium salts ( 25 , 27 and 32-34 ).","PeriodicalId":22122,"journal":{"name":"Sulfur Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85244101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reaction of 3-amino-2-ethoxycarbonylindole ( 1 ) with per- O -acetyl-sugar isothiocyanates 2a-c gave the corresponding glycopyranosyl thioureas 3a-c . The N -nucleosides analogues 3-(per- O -acetyl- β -D-glycopyranosyl)-2-thioxo-5H-3, 4-dihydropyrimido [5,4-b] indol- 4 -one 4a-c were obtained by cyclization of 3a-c in the presence of ZnCl2. Deacetylation of 4a-c with sodium methoxide in methanol yielded the free nucleoside derivatives 5a-c . Alkylation of 5a,b with methyl iodide and benzyl bromide gave good yields of the corresponding 2-methylthio 6a,b and the 2-benzylthio 6c,d analogues. The 2-methylsulfonyl compounds 7a,b were obtained from the corresponding 2-methylthio compounds 6a,b by oxidation with m -chloroperoxybenzoic acid.
3-氨基-2-乙氧基羰基吲哚(1)与每- O -乙酰基糖异硫氰酸酯2a-c反应得到相应的甘氨酰硫脲3a-c。在ZnCl2的存在下，将3a-c环化，得到了N -核苷类似物3-(per- O -乙酰基- β -d -glycopyranosyl)-2-硫氧基- 5h - 3,4 -二氢嘧啶[5,4-b]吲哚- 4- 1 4a-c。4a-c与甲氧基钠在甲醇中脱乙酰化，得到游离核苷衍生物5a-c。5a,b与碘化甲酯和苄基溴的烷基化反应得到了相应的2-甲基硫代6a,b和2-甲基硫代6c,d类似物的良好产率。由相应的2-甲基硫代化合物6a、b与间氯过氧苯甲酸氧化得到2-甲基磺酰基化合物7a、b。
{"title":"A convenient synthesis of novel nucleosides of 2-thioxo-5h-3,4-dihydropyrimido[5,4-b]indol-4-one","authors":"M. Saleh","doi":"10.1080/02786110215845","DOIUrl":"https://doi.org/10.1080/02786110215845","url":null,"abstract":"Reaction of 3-amino-2-ethoxycarbonylindole ( 1 ) with per- O -acetyl-sugar isothiocyanates 2a-c gave the corresponding glycopyranosyl thioureas 3a-c . The N -nucleosides analogues 3-(per- O -acetyl- β -D-glycopyranosyl)-2-thioxo-5H-3, 4-dihydropyrimido [5,4-b] indol- 4 -one 4a-c were obtained by cyclization of 3a-c in the presence of ZnCl2. Deacetylation of 4a-c with sodium methoxide in methanol yielded the free nucleoside derivatives 5a-c . Alkylation of 5a,b with methyl iodide and benzyl bromide gave good yields of the corresponding 2-methylthio 6a,b and the 2-benzylthio 6c,d analogues. The 2-methylsulfonyl compounds 7a,b were obtained from the corresponding 2-methylthio compounds 6a,b by oxidation with m -chloroperoxybenzoic acid.","PeriodicalId":22122,"journal":{"name":"Sulfur Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86131181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
High-level ab initio calculations predicted the strained three-membered trithia[1.1.1]propellane 1a (X=Y=Z=S) to be a tightly-bound molecule which should be experimentally accessible. In analogy to the successful synthesis of'the [1.1.1] propellane, our synthesis strategy focused on the attempted preparation of 1,3-dihalo-trithia-bicyclo[1.1.1] pentanes 2 , to serve as a precursor for the target molecule. However, 1a proved to be unattainable via the planned strategy beyond the stage of the readily synthesized, substituted 1,3-dithietanes 3 , due to the inaccessibility of 2 from the latter. The successfully synthesized 1,3-dithietanes 5c,d are expected to provide 2 , the key precursor of 1 via 1,3-dihalogenation-dehalogenation.
{"title":"In pursuit of the elusive trithia[1.1.1]propellane: Synthesis of potential 1,3-dithietane precursors","authors":"U. Zoller, Fayun Chen","doi":"10.1080/02786110212860","DOIUrl":"https://doi.org/10.1080/02786110212860","url":null,"abstract":"High-level ab initio calculations predicted the strained three-membered trithia[1.1.1]propellane 1a (X=Y=Z=S) to be a tightly-bound molecule which should be experimentally accessible. In analogy to the successful synthesis of'the [1.1.1] propellane, our synthesis strategy focused on the attempted preparation of 1,3-dihalo-trithia-bicyclo[1.1.1] pentanes 2 , to serve as a precursor for the target molecule. However, 1a proved to be unattainable via the planned strategy beyond the stage of the readily synthesized, substituted 1,3-dithietanes 3 , due to the inaccessibility of 2 from the latter. The successfully synthesized 1,3-dithietanes 5c,d are expected to provide 2 , the key precursor of 1 via 1,3-dihalogenation-dehalogenation.","PeriodicalId":22122,"journal":{"name":"Sulfur Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82177468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Issac, Eman El-Karim, S. Donia, Mohamed Behalow
Reaction of 4-(phenoxathiin-2-yl)-1-oxy or mercaptophthalazines 2a,c with phthalyl or tosylamino acids 3 and 4 has been found to yield 5,6a-j . Hydrazinolysis of 5,6a-e furnished amino derivatives 5,6k-o . Some of the newly synthesized products were tested for their antimicrobial activities.
{"title":"Novel synthesis of phthalazine derivatives as antimicrobial agents","authors":"Y. Issac, Eman El-Karim, S. Donia, Mohamed Behalow","doi":"10.1080/02786110213977","DOIUrl":"https://doi.org/10.1080/02786110213977","url":null,"abstract":"Reaction of 4-(phenoxathiin-2-yl)-1-oxy or mercaptophthalazines 2a,c with phthalyl or tosylamino acids 3 and 4 has been found to yield 5,6a-j . Hydrazinolysis of 5,6a-e furnished amino derivatives 5,6k-o . Some of the newly synthesized products were tested for their antimicrobial activities.","PeriodicalId":22122,"journal":{"name":"Sulfur Letters","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72995096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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