A convenient, time efficient, tandem approach for the synthesis of medicinally privileged 3-(3-oxo-3-arylpropyl) quinazolinones is developed from ubiquitously available acetophenones and anthranilamide via microwave irradiation. This transition-metal-free reaction is initiated by the oxidative annulation of anthranilamide and in situ generation of α,β-unsaturated carbonyl compounds from aryl ketones in the presence of K2S2O8 and dimethyl sulfoxide. The latter acts as a source of two carbons [methine (=CH–) and methylene (–CH2–)] apart from being the solvent. The reaction is carried out under microwave irradiation which has the advantage of homogenous heat distribution, reducing the reaction time drastically compared to the conventional heating reaction.
{"title":"DMSO arbitrated Oxidative Annulation Followed by Homologated N-Alkylation: Microwave-Assisted Efficient and Greener Approach to Access 3-(3-Oxo-3-arylpropyl) Quinazolinones","authors":"A. Prasanthi, B. N. Babu","doi":"10.1055/s-0040-1720079","DOIUrl":"https://doi.org/10.1055/s-0040-1720079","url":null,"abstract":"A convenient, time efficient, tandem approach for the synthesis of medicinally privileged 3-(3-oxo-3-arylpropyl) quinazolinones is developed from ubiquitously available acetophenones and anthranilamide via microwave irradiation. This transition-metal-free reaction is initiated by the oxidative annulation of anthranilamide and in situ generation of α,β-unsaturated carbonyl compounds from aryl ketones in the presence of K2S2O8 and dimethyl sulfoxide. The latter acts as a source of two carbons [methine (=CH–) and methylene (–CH2–)] apart from being the solvent. The reaction is carried out under microwave irradiation which has the advantage of homogenous heat distribution, reducing the reaction time drastically compared to the conventional heating reaction.","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":"07 1","pages":"313 - 321"},"PeriodicalIF":2.5,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47033040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karl Ziegler, a scientist from Germany, discovered that combining TiCl4 and Al(C2H5)3 produced a highly active catalyst that could polymerize ethylene in a stereoregular manner at atmospheric pressure. Later, an Italian chemist named Giulio Natta expanded upon Ziegler’s work by developing methods for using the catalyst with other olefins like propylene. Natta also contributed to our understanding of the mechanism behind the polymerization reaction, which led to the development of various forms of the Ziegler catalyst. Over time, scientists have gained more control over stereospecific polymerization thanks to these discoveries.1–4 The Ziegler–Natta catalyst is comprised of transitionmetal chlorides, including titanium, chromium, vanadium, and zirconium chlorides, that have a distinguished lineage, along with organometallic complexes of triethylaluminium. The crystal structure of the titanium chloride compound contains Ti atoms attached to five chlorine atoms on the surface, with one empty orbital. When the compound reacts with Al(C2H5)3, the latter donates an Et group to Ti, causing one chlorine group to detach from Ti.5–7 This reaction activates the catalyst, as illustrated in Scheme 1, and initiates chain propagation and termination steps, also depicted in the same diagram. These polymers are useful for manufacturing plastics, fibers, and films. Ziegler and Natta’s work on this catalyst earned them the Nobel Prize in Chemistry in 1963.8,9 The Ziegler–Natta catalysts have undergone several advancements, resulting in four distinct generations of catalysts. The first generation utilized diethyl aluminum and titanium chloride as co-catalysts. In the second generation of catalysts, titanium chloride/AlEt2Cl was combined with an internal electron donor, such as ether or ester,10,11 which enhanced the activity and stereospecificity of the catalysts. The third generation of catalysts was introduced in 1968,12 and it utilized a catalytic system made up of TiCl4 complexes supported by MgCl2. This method enabled the production of linear polyethylene and isotactic polypropylene. The fourth generation13,14 of catalysts utilized homogeneous catalysts for conducting olefin polymerizations. Over the years, several noteworthy applications of Ziegler–Natta catalysts have been developed.8 Keshav Taruneshwar Jha is a research Scholar and is pursuing his MPharm (Pharmaceutical Chemistry) from ISF College of Pharmacy, Moga, Punjab and is carrying out research under the supervision of Dr. Pooja A. Chawla.
{"title":"Ziegler–Natta Catalysts: Applications in Modern Polymer Science","authors":"K. Jha, Abhimannu Shome, P. Chawla","doi":"10.1055/s-0040-1720078","DOIUrl":"https://doi.org/10.1055/s-0040-1720078","url":null,"abstract":"Karl Ziegler, a scientist from Germany, discovered that combining TiCl4 and Al(C2H5)3 produced a highly active catalyst that could polymerize ethylene in a stereoregular manner at atmospheric pressure. Later, an Italian chemist named Giulio Natta expanded upon Ziegler’s work by developing methods for using the catalyst with other olefins like propylene. Natta also contributed to our understanding of the mechanism behind the polymerization reaction, which led to the development of various forms of the Ziegler catalyst. Over time, scientists have gained more control over stereospecific polymerization thanks to these discoveries.1–4 The Ziegler–Natta catalyst is comprised of transitionmetal chlorides, including titanium, chromium, vanadium, and zirconium chlorides, that have a distinguished lineage, along with organometallic complexes of triethylaluminium. The crystal structure of the titanium chloride compound contains Ti atoms attached to five chlorine atoms on the surface, with one empty orbital. When the compound reacts with Al(C2H5)3, the latter donates an Et group to Ti, causing one chlorine group to detach from Ti.5–7 This reaction activates the catalyst, as illustrated in Scheme 1, and initiates chain propagation and termination steps, also depicted in the same diagram. These polymers are useful for manufacturing plastics, fibers, and films. Ziegler and Natta’s work on this catalyst earned them the Nobel Prize in Chemistry in 1963.8,9 The Ziegler–Natta catalysts have undergone several advancements, resulting in four distinct generations of catalysts. The first generation utilized diethyl aluminum and titanium chloride as co-catalysts. In the second generation of catalysts, titanium chloride/AlEt2Cl was combined with an internal electron donor, such as ether or ester,10,11 which enhanced the activity and stereospecificity of the catalysts. The third generation of catalysts was introduced in 1968,12 and it utilized a catalytic system made up of TiCl4 complexes supported by MgCl2. This method enabled the production of linear polyethylene and isotactic polypropylene. The fourth generation13,14 of catalysts utilized homogeneous catalysts for conducting olefin polymerizations. Over the years, several noteworthy applications of Ziegler–Natta catalysts have been developed.8 Keshav Taruneshwar Jha is a research Scholar and is pursuing his MPharm (Pharmaceutical Chemistry) from ISF College of Pharmacy, Moga, Punjab and is carrying out research under the supervision of Dr. Pooja A. Chawla.","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":"07 1","pages":"293 - 296"},"PeriodicalIF":2.5,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42623578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mangal S Yadav, Abhishek Gupta, Priyanka Bose, Ashutosh Kumar Singh, P. Mohapatra, V. Tiwari
N-Acylbenzotriazoles are valuable synthons in organic synthesis. They are particularly used as acylating agents and an alternative to acyl chloride. They have been widely explored for a diverse range of applications. This review summarizes the methods for the preparation of N-acylbenzotriazole derivatives and their diverse applications in particular demonstration to serve as alternative acylating agents in organic transformations such as N-, O-, C-, and S-acylating agents for the convenient synthesis of a wide range of biologically important organic compounds. We also emphasize the synthesis of diverse compounds using benzotriazole ring cleavage (BtRC) methodology, including its pharmacophore study and some notable utilities as valuable starting materials, ligands, and intermediates in the field of organic synthesis.
{"title":"Synthetic Utility of N -Acylbenzotriazoles","authors":"Mangal S Yadav, Abhishek Gupta, Priyanka Bose, Ashutosh Kumar Singh, P. Mohapatra, V. Tiwari","doi":"10.1055/a-2157-5782","DOIUrl":"https://doi.org/10.1055/a-2157-5782","url":null,"abstract":"N-Acylbenzotriazoles are valuable synthons in organic synthesis. They are particularly used as acylating agents and an alternative to acyl chloride. They have been widely explored for a diverse range of applications. This review summarizes the methods for the preparation of N-acylbenzotriazole derivatives and their diverse applications in particular demonstration to serve as alternative acylating agents in organic transformations such as N-, O-, C-, and S-acylating agents for the convenient synthesis of a wide range of biologically important organic compounds. We also emphasize the synthesis of diverse compounds using benzotriazole ring cleavage (BtRC) methodology, including its pharmacophore study and some notable utilities as valuable starting materials, ligands, and intermediates in the field of organic synthesis.","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":"07 1","pages":"430 - 465"},"PeriodicalIF":2.5,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43754830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Housemberg D. S. Ferrreira, E. Barbosa, A. K. Jordão
Copper sulfate (CuSO4) is a simple, inexpensive, and commercially available salt synthesized by the treatment of cupric oxide with sulfuric acid. Copper sulfate enables a variety of diverse reactions and functionalization, that include: triazole formation, reduction of alkenes and alkynes, complexes formation, among others. In organic synhesis, this compound is normally used as a catalyst for reactions, due to its low cost, possibility of use at low temperatures and ecological advantages.
{"title":"Copper Sulfate (CuSO 4 ): An Efficient Reagent in Organic Synthesis","authors":"Housemberg D. S. Ferrreira, E. Barbosa, A. K. Jordão","doi":"10.1055/a-2134-9007","DOIUrl":"https://doi.org/10.1055/a-2134-9007","url":null,"abstract":"Copper sulfate (CuSO4) is a simple, inexpensive, and commercially available salt synthesized by the treatment of cupric oxide with sulfuric acid. Copper sulfate enables a variety of diverse reactions and functionalization, that include: triazole formation, reduction of alkenes and alkynes, complexes formation, among others. In organic synhesis, this compound is normally used as a catalyst for reactions, due to its low cost, possibility of use at low temperatures and ecological advantages.","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":"07 1","pages":"371 - 373"},"PeriodicalIF":2.5,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48550797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suitably protected mono- and di-saccharide residues associated with the glucuronic acid-containing repeat unit (1) related to pentosan polysulfate have been prepared. The stereo-controlled coupling, using trichloroacetimidate chemistry, of certain of these is also described and the
{"title":"Synthesis of the Key Saccharide Fragments of the Glucuronic Acid-Containing Repeat Unit of Pentosan Polysulfate, a Heparin Sulfate Mimetic","authors":"M. Banwell, Sarah Marshall, J. Ward, B. Schwartz","doi":"10.1055/a-2126-0346","DOIUrl":"https://doi.org/10.1055/a-2126-0346","url":null,"abstract":"Suitably protected mono- and di-saccharide residues associated with the glucuronic acid-containing repeat unit (1) related to pentosan polysulfate have been prepared. The stereo-controlled coupling, using trichloroacetimidate chemistry, of certain of these is also described and the","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":"07 1","pages":"381 - 393"},"PeriodicalIF":2.5,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42680054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yana I Sakhno, Oleksandr V Radchenko, V. Saraev, Yuliia V. Shliapkina, Mariia B. Kaidash, Mariia O Shyshkina, S. Shishkina, V. Musatov, S. Desenko, V. Chebanov
Novel peptidomimetics containing a pyrrolone fragment were synthesized by a tandem combination of Doebner and Ugi-type multicomponent reactions with controlled diastereoselectivity. This approach represents a convenient synthesis in the temperature range from 25 °C to 45 °C. In most cases, the new method allowed each diastereomer to be isolated separately.
{"title":"Temperature-Controlled Diastereoselective Doebner/Ugi Tandem Reaction","authors":"Yana I Sakhno, Oleksandr V Radchenko, V. Saraev, Yuliia V. Shliapkina, Mariia B. Kaidash, Mariia O Shyshkina, S. Shishkina, V. Musatov, S. Desenko, V. Chebanov","doi":"10.1055/a-2091-7934","DOIUrl":"https://doi.org/10.1055/a-2091-7934","url":null,"abstract":"Novel peptidomimetics containing a pyrrolone fragment were synthesized by a tandem combination of Doebner and Ugi-type multicomponent reactions with controlled diastereoselectivity. This approach represents a convenient synthesis in the temperature range from 25 °C to 45 °C. In most cases, the new method allowed each diastereomer to be isolated separately.","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":"07 1","pages":"258 - 266"},"PeriodicalIF":2.5,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47372632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hexamethyldisilathiane (TMS2S), also named bis(trimethylsilyl) sulfide, (CAS: 3385-94-2), was reported for the first time in the early 1950’s.1 This liquid compound (bp 160 °C) was prepared by the reaction between iodotrimethylsilane and silver sulfide. Alternatively, bis(trimethylsilyl) sulfide has been also prepared by the addition of disodium sulfide on chlorotrimethylsilane.1,2 TMS2S is nowadays commercially available (ca. 28 €/g).3 This reagent can be viewed as a S1 source of sulfide that is less toxic, less flammable, and easier to handle than gaseous hydrogen sulfide (H2S). On contact with water, TMS2S releases H2S and should be stored in a cold and dry place in an oxygen-free atmosphere. TMS2S is used as a sulfur transfer agent for the synthesis of alkyl sulfides, thioaldehydes, or thioketones but also as a reducing agent.4 TMS2S is also employed in the synthesis of inorganic–organic hybrid clusters5 or phosphinidene sulfide compounds.6 It is noteworthy that the number of publications describing the use of TMS2S has steadily increased since the 1950’s to reach an average of 65 publications per year from 2015 to 2022.7 This Spotlight article highlights the versatility of TMS2S as a S1 source of sulfides and its recent applications in organic synthesis. In 1999, Hu and Fox reported a trimethylsilylthioxy dehalogenation reaction for the synthesis of functionalized thiols (Table 1, A).8 In this process, tetrabutylammonium trimethylsilylthiolate (Me3SiSBu4N), generated in situ Dr Damien Hazelard (right) obtained his PhD in 2005 under the supervision of Dr A. Fadel (Paris-Sud University). In 2006, he performed a postdoctoral training in the field of organocatalysis in the group of Prof. Y. Hayashi at the Tokyo University of Science. Then he joined the group of Prof. F. Colobert to work on total synthesis at the University of Strasbourg. He was appointed in 2010 as assistant professor at the same university in the group of Prof. P. Compain. In July 2019, he defended his habilitation (‘Habilitation à Diriger des Recherches’). His main research interests are the development of new synthetic methodologies for the synthesis of glycomimetics.
{"title":"Recent Applications of Hexamethyldisilathiane (TMS 2 S) in Organic Synthesis","authors":"D. Hazelard, P. Compain","doi":"10.1055/s-0040-1720071","DOIUrl":"https://doi.org/10.1055/s-0040-1720071","url":null,"abstract":"Hexamethyldisilathiane (TMS2S), also named bis(trimethylsilyl) sulfide, (CAS: 3385-94-2), was reported for the first time in the early 1950’s.1 This liquid compound (bp 160 °C) was prepared by the reaction between iodotrimethylsilane and silver sulfide. Alternatively, bis(trimethylsilyl) sulfide has been also prepared by the addition of disodium sulfide on chlorotrimethylsilane.1,2 TMS2S is nowadays commercially available (ca. 28 €/g).3 This reagent can be viewed as a S1 source of sulfide that is less toxic, less flammable, and easier to handle than gaseous hydrogen sulfide (H2S). On contact with water, TMS2S releases H2S and should be stored in a cold and dry place in an oxygen-free atmosphere. TMS2S is used as a sulfur transfer agent for the synthesis of alkyl sulfides, thioaldehydes, or thioketones but also as a reducing agent.4 TMS2S is also employed in the synthesis of inorganic–organic hybrid clusters5 or phosphinidene sulfide compounds.6 It is noteworthy that the number of publications describing the use of TMS2S has steadily increased since the 1950’s to reach an average of 65 publications per year from 2015 to 2022.7 This Spotlight article highlights the versatility of TMS2S as a S1 source of sulfides and its recent applications in organic synthesis. In 1999, Hu and Fox reported a trimethylsilylthioxy dehalogenation reaction for the synthesis of functionalized thiols (Table 1, A).8 In this process, tetrabutylammonium trimethylsilylthiolate (Me3SiSBu4N), generated in situ Dr Damien Hazelard (right) obtained his PhD in 2005 under the supervision of Dr A. Fadel (Paris-Sud University). In 2006, he performed a postdoctoral training in the field of organocatalysis in the group of Prof. Y. Hayashi at the Tokyo University of Science. Then he joined the group of Prof. F. Colobert to work on total synthesis at the University of Strasbourg. He was appointed in 2010 as assistant professor at the same university in the group of Prof. P. Compain. In July 2019, he defended his habilitation (‘Habilitation à Diriger des Recherches’). His main research interests are the development of new synthetic methodologies for the synthesis of glycomimetics.","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":"07 1","pages":"267 - 271"},"PeriodicalIF":2.5,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44575405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. S. Phull, S. S. Jadav, Chander Singh Bohara, R. Gundla, P. Mainkar
Praziquantel (PZQ; Brand name: Biltricide) is categorized as an anthelminthic drug, and it is used for the treatment of Schistosomiasis and other parasitic infections. The World Health Organization (WHO) has classified it as one of the essential and emergency medicines needed across the globe. The price of PZQ formulated product depends on the associated method of preparation, along with cost of raw materials. A precise and reliable method for the preparation of PZQ using a flow-chemistry approach is described in this study using phenylethylamine as the starting material. The main objective of the present study is to identify a new economical route for the synthesis of PZQ that could decrease the production time drastically from days to minutes and be transferred to large-scale production. Simultaneously, the purity of the obtained intermediates in essential steps, as single or continuous process, determined by HPLC analysis were more than 90% pure. The continuous preparation process of PZQ in the current study was achieved in less time (ca. 3–4 h) than using conventional methods (ca. 3–4 days). Moreover, the required quantity of key intermediate dimethoxyethanamine is 40–50% less than in existing methods.
{"title":"Multi-step Flow Synthesis of the Anthelmintic Drug Praziquantel","authors":"M. S. Phull, S. S. Jadav, Chander Singh Bohara, R. Gundla, P. Mainkar","doi":"10.1055/s-0042-1751479","DOIUrl":"https://doi.org/10.1055/s-0042-1751479","url":null,"abstract":"Praziquantel (PZQ; Brand name: Biltricide) is categorized as an anthelminthic drug, and it is used for the treatment of Schistosomiasis and other parasitic infections. The World Health Organization (WHO) has classified it as one of the essential and emergency medicines needed across the globe. The price of PZQ formulated product depends on the associated method of preparation, along with cost of raw materials. A precise and reliable method for the preparation of PZQ using a flow-chemistry approach is described in this study using phenylethylamine as the starting material. The main objective of the present study is to identify a new economical route for the synthesis of PZQ that could decrease the production time drastically from days to minutes and be transferred to large-scale production. Simultaneously, the purity of the obtained intermediates in essential steps, as single or continuous process, determined by HPLC analysis were more than 90% pure. The continuous preparation process of PZQ in the current study was achieved in less time (ca. 3–4 h) than using conventional methods (ca. 3–4 days). Moreover, the required quantity of key intermediate dimethoxyethanamine is 40–50% less than in existing methods.","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":"07 1","pages":"362 - 370"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43169886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An electrochemical/I− dual-catalyzed access to sulfonated pyrazoles from pyrazolones and sodium sulfites under external oxidant-free conditions has been developed. This established electrochemical reaction works smoothly under external oxidant-free conditions, and has the advantages of good functional group tolerance, easy to gram-scale synthesis, delivering up to 95% yield for 35 examples.
{"title":"Electrochemical/I – Dual-Catalyzed Access to Sulfonated Pyrazoles under External Oxidant-Free Conditions","authors":"Jing Ma, Jianjing Yang, Kelu Yan, Boju Luo, Kexin Huang, Ziling Wu, Yumeng Zhou, Shuyun Zhu, Xian-En Zhao, Jiangwei Wen","doi":"10.1055/a-2089-0485","DOIUrl":"https://doi.org/10.1055/a-2089-0485","url":null,"abstract":"An electrochemical/I− dual-catalyzed access to sulfonated pyrazoles from pyrazolones and sodium sulfites under external oxidant-free conditions has been developed. This established electrochemical reaction works smoothly under external oxidant-free conditions, and has the advantages of good functional group tolerance, easy to gram-scale synthesis, delivering up to 95% yield for 35 examples.","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":"07 1","pages":"272 - 276"},"PeriodicalIF":2.5,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46949188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：