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Recent Developments in Ultrasound-Promoted Aqueous-Mediated Greener Synthesis of Biologically Vital Indole Derivatives 超声促进水介导的吲哚衍生物绿色合成研究进展
IF 2.5 Q2 CHEMISTRY, ORGANIC Pub Date : 2023-01-05 DOI: 10.1055/a-2081-9249
Kanaram Choupra, Ashish Kumar Aheer, A. Dandia, Meenakshi Jain, Amit Sharma
The extensive usefulness of N-heterocycles as potent bioactive motifs has attracted researchers to expand newer methods for their efficient synthesis. Particularly, indoles are widely known for their prevalent pharmacological properties. Green chemistry provides various facile synthetic tools viz. alternative energy resources, nonconventional solvents, nano-catalysts, etc. Modern strategies of using ultrasound waves as alternative energy resource in organic synthesis lead to the development of environment friendly and cost effective techniques. The chemical and mechanical effects of ultrasound waves impart significant enhancement in both stoichiometric and catalytic reactions. The exclusive physicochemical properties of water offer its widespread utility for carrying out organic reactions in it. The aim of this review article is to provide an inclusive summary of combined use of ultrasound and aqueous media for the facile synthesis of biologically vital indole derivatives.
N-杂环作为有效的生物活性基序的广泛用途吸引了研究人员扩展其有效合成的新方法。特别地,吲哚以其普遍的药理学特性而广为人知。绿色化学提供了各种简单的合成工具,即替代能源、非常规溶剂、纳米催化剂等。在有机合成中使用超声波作为替代能源的现代策略导致了环境友好和成本效益高的技术的发展。超声波的化学和机械效应显著增强了化学计量反应和催化反应。水独特的物理化学性质为在水中进行有机反应提供了广泛的用途。这篇综述文章的目的是全面总结超声和水性介质的联合应用,以方便合成具有生物活性的吲哚衍生物。
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引用次数: 0
Ethyl Diazoacetate 重氮乙酸乙酯
IF 2.5 Q2 CHEMISTRY, ORGANIC Pub Date : 2023-01-02 DOI: 10.1055/a-2038-6055
G. Aquino, F. Silva-Jr, S. Ferreira
Ethyl diazoacetate (EDA) is a very important reagent for different types of organic reactions. It can be used to synthesize cyclopropanes, cyclopropenes, triazoles and pyrazolines, and also for cycloaddition reactions, reactions involving transition metals, olefinations of aldehydes, when it is necessary to introduce an ester group in the molecule scaffold, and in processes like continuous flow methods. In summary, EDA is a first-choice reagent for many organic chemists in their daily reactions.
重氮乙酸乙酯(EDA)是用于不同类型有机反应的一种非常重要的试剂。它可用于合成环丙烷、环丙烯、三唑和吡唑啉,也可用于环加成反应、涉及过渡金属的反应、醛的油化反应,当需要在分子支架中引入酯基时,以及在连续流法等工艺中。总之,EDA是许多有机化学家在日常反应中的首选试剂。
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引用次数: 0
Nickel-Catalyzed Heck Reaction 镍催化Heck反应
IF 2.5 Q2 CHEMISTRY, ORGANIC Pub Date : 2022-12-30 DOI: 10.1055/s-0042-1751432
P. Gahlot, Kavita Mittal
Bai research group 19 constructed three dimensional Ni carbon nanofibers (Ni/CNFs) and explored it as heterogeneous catalyst for Heck coupling reaction. Iodobenzene and n -butyl acrylate reacted successfully taking small amount of catalyst Ni/CNFs and Et 3 N as base in N -methylpyrrolidone solvent to furnish butyl cinnamate with good product selectivity
白19研究组构建了三维镍碳纳米纤维(Ni/CNFs),并探索其作为Heck偶联反应的多相催化剂。在n -甲基吡咯烷酮溶剂中,以少量催化剂Ni/CNFs和Et 3n为碱,碘苯与丙烯酸正丁酯反应成功,生成了具有良好产物选择性的肉桂酸丁酯
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引用次数: 0
Zinc Oxide (ZnO): an Amphoteric Metal Oxide with Dehydrogenating Activity 氧化锌:一种具有脱氢活性的两性金属氧化物
IF 2.5 Q2 CHEMISTRY, ORGANIC Pub Date : 2022-12-27 DOI: 10.1055/a-2063-4007
R. Ballesteros-Garrido, Rosa Adam
Zinc oxide presents a remarkable activity as catalyst or co-catalyst in different dehydrogenative processes. Borrowing hydrogen reactions as well as acceptorless dehydrogenative condensations have been reported with ZnO, affording value added compounds in fine and bulk chemistry.
氧化锌作为催化剂或助催化剂在不同的脱氢过程中表现出显著的活性。已经报道了与ZnO的借氢反应以及无受体脱氢缩合,在精细化学和本体化学中提供了增值化合物。
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引用次数: 0
CN-Doped Cobalt Oxide Composite: An Economic and Reusable Catalyst with Multitasking Catalytic Capability for Alkyne and Nitrile Hydrations and Nitro Reductions CN掺杂的氧化钴复合材料:一种经济且可重复使用的催化剂,对炔烃、腈的水合和硝基还原具有多任务催化能力
IF 2.5 Q2 CHEMISTRY, ORGANIC Pub Date : 2022-12-20 DOI: 10.1055/a-2025-2759
A. K. Srivastava, Himanshu Khandaka, R. Joshi
A heterogeneous CoOCN composite, synthesized via a one-pot reaction of [Co(NO3)2] and urea at 500 °C in muffle furnace. The composite was fully characterized by the FTIR, Raman, powder XRD and XPS techniques. The catalyst was found to be efficient for the hydrations of aryl alkynes and nitriles under aerobic conditions. Apart of that, the catalyst exhibits high catalytic performance for the reduction of nitroarenes under the inert gas free conditions. This multitasking CoOCN was found to be highly significant for the all derivatives of nitrobenzene, alkynes and nitriles as good to excellent yields were obtained. The catalyst was recovered quantitatively from the reaction mixture by simple filtration and consequently reused for seven consecutive cycles in all reactions without significant loss of catalytic activity. Hence, the synthesized CN doped CoOCN composite worked as multitasking catalyst for various value added organic transformations, and it is highly economical and reusable upto seven catalytic cycles without any activation, even the last cycle was producing a reasonable yields up to 48-50%.
一种非均相CoOCN复合材料,通过[Co(NO3)2]和尿素在马弗炉中在500°C下的一锅反应合成。用红外光谱、拉曼光谱、粉末X射线衍射和X射线光电子能谱对复合材料进行了表征。发现该催化剂在好氧条件下对芳基炔烃和腈的水合是有效的。除此之外,该催化剂在无惰性气体条件下对硝基芳烃的还原表现出高催化性能。发现这种多任务CoOCN对硝基苯、炔烃和腈的所有衍生物都非常重要,因为可以获得良好到优异的产率。通过简单过滤从反应混合物中定量回收催化剂,并因此在所有反应中重复使用七个连续循环而没有显著的催化活性损失。因此,合成的CN掺杂的CoOCN复合物可以作为多种增值有机转化的多任务催化剂,并且在没有任何活化的情况下,它是高度经济和可重复使用的,长达七个催化循环,即使最后一个循环也能产生高达48-50%的合理产率。
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引用次数: 0
Palladium-Mediated Reductive Heck Cyclization for the Synthesis of Fused Retinoid Derivatives 钯介导的还原Heck环化反应合成熔融类维甲酸衍生物
IF 2.5 Q2 CHEMISTRY, ORGANIC Pub Date : 2022-12-17 DOI: 10.1055/a-2022-3227
Trisha Mitra, S. Joardar, S. Chakravorty, Manoj Majumdar, M. Kundu, B. Roy
Linearly fused Retinoids derivatives have been synthesized via a straightforward pathway using palladium-catalyzed reductive Heck cyclization strategy. The synthesis involved a four step linear approach utilizing iodination, sulfonylation or benzylation or esterfication, palladium- catalyzed Sonogashira cross-coupling and palladium mediated reductive Heck cyclization.
利用钯催化的还原Heck环化策略,通过简单的途径合成了线性融合的类维甲酸衍生物。通过碘化、磺化、苄基化或酯化、钯催化的Sonogashira交叉偶联和钯介导的还原Heck环化四步线性合成。
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引用次数: 1
Langlois Reagent: An Efficient Trifluoromethylation Reagent 朗格卢瓦试剂:一种高效三氟甲基化试剂
IF 2.5 Q2 CHEMISTRY, ORGANIC Pub Date : 2022-12-15 DOI: 10.1055/a-2024-1382
K. Anusha, Megha Mahesh, S. Shikha, T. Rangarajan, Sharda Pasricha
Abstract Keywords:Langlois’ reagent, trifluoromethylation, free radical, fluoroorganic synthesis, sodium trifluoromethane sulfinate or sodium triflinate
关键词:朗格卢瓦试剂,三氟甲基化,自由基,氟有机合成,三氟甲烷亚硫酸钠或三氟化钠
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引用次数: 0
Frustrated Lewis Pair Catalyzed Reactions 受挫刘易斯对催化反应
IF 2.5 Q2 CHEMISTRY, ORGANIC Pub Date : 2022-12-14 DOI: 10.1055/a-2005-5443
Rundong Zhou, Zoleykha Tavandashti, J. Paradies
In recent years, frustrated Lewis pairs have been widely used in small molecules activation and catalytic transformations. This graphic review is aimed to provide the fundamental understanding of frustrated Lewis pair reactivity and the exploitation thereof in catalytic reactions.
近年来,受挫路易斯对在小分子活化和催化转化中得到了广泛的应用。这篇综述的目的是提供对路易斯对反应性的基本理解和在催化反应中的应用。
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引用次数: 0
Solid-Supported Heterogenized Palladium Nanoparticles: Propitious Vehicles for Sonogashira Cross-Coupling Reaction 固体负载多相化钯纳米颗粒:Sonogashira交叉偶联反应的有利载体
IF 2.5 Q2 CHEMISTRY, ORGANIC Pub Date : 2022-12-14 DOI: 10.1055/a-2011-9319
Abhay Srivastava, Nishita Avasthi, sachid Anand, D. Yadav, T. Rangarajan, Sharda Pasricha
Abstract Keywords: Palladium, Sonogashira, Heterogeneous catalysis, supported nanoparticles
关键词:钯,Sonogashira,多相催化,负载纳米颗粒
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引用次数: 0
Selective Syntheses of Coumarin and Benzofuran Derivatives Using Phenols and α-Methoxy-β-ketoesters 酚类化合物和α-甲氧基-β-酮酯类化合物选择性合成香豆素和苯并呋喃衍生物
IF 2.5 Q2 CHEMISTRY, ORGANIC Pub Date : 2022-12-11 DOI: 10.1055/s-0042-1751408
R. Miyata, Takashi Shigeta, S. Kumazawa, M. Egi
Selective syntheses of coumarin and benzofuran derivatives were achieved via HClO4-mediated intermolecular annulation using phenols and α-methoxy-β-ketoesters. Coumarins are formed under dehydrated conditions, whereas benzofurans are formed in the presence of water. In the synthetic process of benzofurans, α-methoxy-β-ketoesters are converted into α-methoxyacetophenones, and the methoxy group is an important element in the intermolecular annulation.
以苯酚和α-甲氧基-β-酮酯为原料,通过hclo4介导的分子间环化反应选择性合成香豆素和苯并呋喃衍生物。香豆素是在脱水条件下形成的,而苯并呋喃是在有水的情况下形成的。在苯并呋喃的合成过程中,α-甲氧基-β-酮酯转化为α-甲氧基苯乙酮,甲氧基是分子间环化的重要元素。
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引用次数: 1
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