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Efficacy and safety of supraglottic jet oxygenation and ventilation to minimize sedation-related hypoxemia: a meta-analysis with GRADE approach. 声门上喷射供氧和通气以最大限度减少镇静相关低氧血症的有效性和安全性:采用 GRADE 方法进行的荟萃分析。
IF 6.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-14 DOI: 10.1186/s13643-024-02707-w
I-Wen Chen, Wei-Ting Wang, Pei-Chun Lai, Chun-Ning Ho, Chien-Ming Lin, Yao-Tsung Lin, Yen-Ta Huang, Kuo-Chuan Hung

Introduction: Hypoxemia is a common complication of sedation. This meta-analysis aimed to evaluate the efficacy and safety of supraglottic jet oxygenation and ventilation (SJOV) in preventing hypoxemia during sedative procedures.

Methods: Randomized controlled trials (RCTs) that compared SJOV with conventional oxygen therapy in sedated patients were searched in five databases (MEDLINE, EMBASE, Cochrane Library, China National Knowledge Infrastructure [CNKI], and Google Scholar) from their inception to March 2024. The primary outcome was the proportion of patients who developed hypoxia (SpO2 < 90%). The secondary outcomes included subclinical respiratory depression (90% ≤ SpO2 < 95%), severe hypoxemia (SpO2 < 75%), airway interventions, adverse events, hemodynamics, propofol dosage, and procedure time. The certainty of evidence was determined using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

Results: Twelve trials (n = 3058) were included in the analysis. The evidence suggests that SJOV results in a large reduction in the risk of hypoxemia (risk ratio [RR], 0.26; 95% confidence interval, 0.19-0.36; low certainty) and subclinical respiratory depression (RR, 0.40; low certainty) compared with the control. SJOV likely resulted in a large reduction in the risk of severe hypoxemia (RR, 0.22; moderate certainty). In addition, it may result in a large reduction in the need for jaw lift (RR, 0.22; low certainty) and mask ventilation (RR, 0.13; low certainty). The risk of sore throat probably increases with SJOV (RR, 1.71; moderate certainty), whereas SJOV may result in little to no difference in nasal bleeding (RR, 1.75; low certainty). Evidence is very uncertain regarding the effect of SJOV on hemodynamics (very low certainty) and procedure time (very low certainty). SJOV probably resulted in little to no difference in sedative doses between the groups (moderate certainty).

Conclusion: According to the GRADE approach, SJOV likely results in a large reduction in the risk of severe hypoxemia but probably increases the risk of sore throat. Compared with the control, evidence suggests that SJOV results in a large reduction in the risk of hypoxemia, subclinical respiratory depression, and the need for airway manipulation, with little to no difference in nasal bleeding. The integration of SJOV into clinical practice may help minimize hypoxemic events in at-risk patients.

简介低氧血症是镇静过程中常见的并发症。本荟萃分析旨在评估声门上喷射供氧和通气(SJOV)在镇静手术中预防低氧血症的有效性和安全性:方法:在五个数据库(MEDLINE、EMBASE、Cochrane Library、中国国家知识基础设施[CNKI]和谷歌学术)中检索了从开始到2024年3月对镇静患者进行SJOV与传统氧疗比较的随机对照试验(RCT)。主要结果是出现缺氧的患者比例(SpO2 2 2 结果:12 项试验(n = 3058)被纳入分析。证据表明,与对照组相比,SJOV 可大幅降低低氧血症(风险比 [RR],0.26;95% 置信区间,0.19-0.36;低确定性)和亚临床呼吸抑制(RR,0.40;低确定性)的风险。SJOV 很可能会大大降低严重低氧血症的风险(RR,0.22;中等确定性)。此外,SJOV 还可大大减少下颌抬高(RR,0.22;低度确定性)和面罩通气(RR,0.13;低度确定性)的需要。SJOV 可能会增加喉咙痛的风险(RR,1.71;中等确定性),而 SJOV 可能导致的鼻出血差异很小甚至没有(RR,1.75;低确定性)。关于 SJOV 对血液动力学(确定性极低)和手术时间(确定性极低)的影响,证据非常不确定。SJOV可能导致各组间镇静剂剂量几乎没有差异(中等确定性):根据 GRADE 方法,SJOV 可能会大大降低严重低氧血症的风险,但可能会增加喉咙痛的风险。与对照组相比,有证据表明 SJOV 可大大降低低氧血症、亚临床呼吸抑制和气道操作需求的风险,而鼻出血方面几乎没有差异。将 SJOV 纳入临床实践可能有助于最大限度地减少高危患者的低氧血症事件。
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引用次数: 0
The pyroptosis and fibrotic diseases: a bibliometric analysis from 2010 to 2024. 热病与纤维化疾病:2010 年至 2024 年的文献计量分析。
IF 6.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-13 DOI: 10.1186/s13643-024-02703-0
Long Zhu, Lijia Ou, Binjie Liu, Yang Yang, Chang Su, Ousheng Liu, Hui Feng

Background: Fibrosis is the ultimate, common pathological ending of most chronic inflammatory diseases and increases the chances of developing life-threatening illnesses. Pyroptosis, a newfound form of lytic programmed cell death initiated by the inflammasome, has received more and more attention because of its association with fibrotic diseases. Therefore, this study visualizes the connection between pyroptosis and fibrosis research through bibliometric methods, aimed at providing global research hits and tendencies in the field.

Methods: We collected and analyzed the articles on pyroptosis and fibrosis from 2010 to 2024 via Web of Science. Visual data analysis was performed for countries, institutions, authors, references, and keywords in the field using VOSviewer, CiteSpace software, the "Bibliometrix" R package, the bibliometric website ( https://bibliometric.com/ ), and Excel software. We analyzed the data by utilizing the bibliometric review method.

Results: A total of 566 articles and reviews relating to pyroptosis and fibrosis were identified in the Web of Science. The number of publications in the domain has continued to grow since 2010. These scientific outputs were mainly from 129 countries/regions and 1919 institutions, particularly China (n = 423) and the USA (n = 83). More importantly, although China publishes a vast majority of articles, its centrality is lower than that of the USA (0.59 vs 0.61). Among the 3833 authors involved in this field, Feldstein, A. E. is the most prolific author. Shi, J. J. is the world's most-cited author among the 12,143 authors in these academic journals. Frontiers in Immunology was a prolific contributor, and Nature was the most frequently cited journal. After analysis, Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death were the top-cited articles. The analysis of keywords displayed that pyroptosis, fibrosis, and pathways were the main research hotspots and frontier directions in recent years.

Conclusion: We analyzed the characteristics of published articles and drew a fundamental knowledge structure on pyroptosis and fibrosis research via bibliometric analysis. The potential mechanism between fibrosis and pyroptosis is deeply tied to the current moment. Our findings can help researchers make clear the research status and value of fibrosis and pyroptosis and provide new directions for future research as soon as possible.

背景:纤维化是大多数慢性炎症性疾病的最终常见病理结局,会增加患上危及生命的疾病的几率。由炎性体引发的一种新发现的细胞溶解性程序性死亡形式--裂解酶,因其与纤维化疾病的关联而受到越来越多的关注。因此,本研究通过文献计量学方法直观地展示了热蛋白沉积症与纤维化研究之间的联系,旨在提供该领域的全球研究热点和趋势:我们通过 Web of Science 收集并分析了 2010 年至 2024 年有关热蛋白沉积症和纤维化的文章。我们使用 VOSviewer、CiteSpace 软件、"Bibliometrix "R 软件包、文献计量学网站 ( https://bibliometric.com/ ) 和 Excel 软件对该领域的国家、机构、作者、参考文献和关键词进行了可视化数据分析。我们利用文献计量学审查方法对数据进行了分析:结果:我们在 Web of Science 上共找到了 566 篇与热病和纤维化相关的文章和综述。自 2010 年以来,该领域的论文数量持续增长。这些科学成果主要来自 129 个国家/地区和 1919 个机构,尤其是中国(n = 423)和美国(n = 83)。更重要的是,尽管中国发表了绝大多数文章,但其中心度却低于美国(0.59 对 0.61)。在该领域的 3833 位作者中,Feldstein, A. E. 是最多产的作者。在这些学术期刊的 12,143 位作者中,Shi, J. J. 是世界上被引用次数最多的作者。免疫学前沿》是多产作者,《自然》是被引用次数最多的期刊。经过分析,GSDMD 被炎性 Caspases 分解决定了细胞的热解死亡是被引用最多的文章。关键词分析表明,热变态、纤维化和通路是近年来的主要研究热点和前沿方向:我们分析了已发表文章的特点,并通过文献计量学分析得出了热解和纤维化研究的基本知识结构。纤维化与热蛋白沉积之间的潜在机制与当下的研究息息相关。我们的研究结果可以帮助研究人员明确纤维化和热病的研究现状和价值,并尽快为未来的研究提供新的方向。
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引用次数: 0
A systematic review and meta-analysis of factors contributing to post-kidney transplant anemia and the effect of erythropoietin-stimulating agents. 对导致肾移植后贫血的因素及促红细胞生成素药物效果的系统回顾和荟萃分析。
IF 6.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-12 DOI: 10.1186/s13643-024-02709-8
Kittiphan Chienwichai, Supitchaya Phirom, Thunyatorn Wuttiputhanun, Asada Leelahavanichkul, Natavudh Townamchai, Yingyos Avihingsanon, Suwasin Udomkarnjananun

Background: The effects of various risk and associated factors on post-kidney transplant anemia (PTA) have not been fully compared and estimated. This meta-analysis aims to elucidate factors contributing to PTA and determine the influence of erythropoietin-stimulating agents (ESAs) on renal outcomes, thus offering potential pathways for enhanced management strategies post-transplant.

Methods: A systematic review was conducted in electronical database. Studies reporting on risk factors (with cause-effect relationships) and associated factors (without definite cause-effect relationships) of PTA, and the effects of ESAs on post-kidney transplant outcomes, were included. Pooled odds ratios (ORs) and weighted mean differences (WMDs) were analyzed using random-effects models.

Results: This systematic review encompassed 38,233 patients from 85 studies. Factors increased PTA risk included African American, older donor age, human antigen leukocyte mismatches, and low pre-transplant hemoglobin levels. Poor allograft function, high interleukine-6, Cytomegalovirus, delayed graft function, allograft rejections, immunosuppressive medications, and renin-angiotensin system blockades were associated with PTA. Native autosomal dominant polycystic kidney disease was a protective factor against PTA. Administration of ESAs with the aim of normalizing hemoglobin levels in patients with chronic allograft dysfunction slowed the decline in eGFR and reduce the risk of death, with a pooled OR of 0.36 (95% CI: 0.14 to 0.89; p = 0.040).

Conclusions: The risks and associated factors for PTA have been elucidated, underscoring the need for individualized treatment approaches. Late ESA therapy, aimed at hemoglobin normalization, suggests a renal-protective effect and reduced mortality, which should be considered in the management of PTA.

Systematic review registration: PROSPERO CRD42024545330.

背景:各种风险和相关因素对肾移植后贫血(PTA)的影响尚未得到充分比较和估计。本荟萃分析旨在阐明导致 PTA 的因素,并确定促红细胞生成素(ESAs)对肾脏预后的影响,从而为加强移植后管理策略提供潜在途径:方法:在电子数据库中进行了系统性回顾。方法:在电子数据库中进行了系统性综述,纳入了报告 PTA 风险因素(有因果关系)和相关因素(无明确因果关系)以及 ESA 对肾移植后预后影响的研究。采用随机效应模型分析了汇总的几率比(ORs)和加权平均差(WMDs):本系统综述涵盖了 85 项研究中的 38,233 名患者。增加 PTA 风险的因素包括非裔美国人、供体年龄较大、人类抗原白细胞不匹配以及移植前血红蛋白水平低。异体移植功能差、白细胞介素-6 高、巨细胞病毒、移植功能延迟、异体移植排斥、免疫抑制药物和肾素-血管紧张素系统阻断与 PTA 相关。原发性常染色体显性多囊肾是 PTA 的保护因素。为使慢性异体移植功能障碍患者的血红蛋白水平恢复正常而服用ESAs,可减缓eGFR的下降并降低死亡风险,汇总OR值为0.36(95% CI:0.14至0.89;P = 0.040):结论:PTA 的风险和相关因素已被阐明,强调了个体化治疗方法的必要性。以血红蛋白正常化为目标的晚期ESA治疗具有肾脏保护作用,并能降低死亡率,在治疗PTA时应加以考虑:系统综述注册:PREMCORD42024545330。
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引用次数: 0
Involvement of family caregivers in dementia care research: a scoping review protocol. 痴呆症护理研究中家庭护理人员的参与:范围界定审查协议。
IF 6.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-11 DOI: 10.1186/s13643-024-02696-w
Franziska Anushi Jagoda, Julian Hirt, Claudia Mueller, Margareta Halek

Background: Family caregivers of people with dementia are a distinct group due to the particularly stressful and time-intensive care situation at home. Despite these challenges, involving them in research is crucial to better understand and address their specific needs. However, little evidence exists regarding a tailored approach for researchers for this group considering their situation at home.

Methods: A scoping review will be conducted following the Joanna Briggs Institute methodological guidance, including the databases MEDLINE (PubMed), CINAHL, Scopus (Elsevier), and PsycINFO (EBSCO). The review will include family caregivers of people with dementia, regardless of age, gender, or ethnicity, who have been actively involved in research throughout the research process. Moreover, sources of evidence from any country in both English and German are eligible for inclusion. Sources will be screened by two independent reviewers. Results will be extracted using a tailored charting tool and presented in the final report according to the research questions and objectives.

Discussion: Developing a tailored approach to involve family caregivers of people with dementia in research and development has profound importance to both the scientific community and the target group itself.

Systematic review registration: Open Science Framework https://doi.org/10.17605/OSF.IO/PMZYV .

背景:痴呆症患者的家庭照护者是一个特殊的群体,因为他们在家中的照护工作压力特别大,时间特别紧张。尽管存在这些挑战,但让他们参与研究对于更好地了解和满足他们的特殊需求至关重要。然而,考虑到这一群体在家中的处境,研究人员为他们量身定制的研究方法却鲜有证据:将按照乔安娜-布里格斯研究所的方法指南进行范围界定综述,包括 MEDLINE (PubMed)、CINAHL、Scopus (Elsevier) 和 PsycINFO (EBSCO) 等数据库。综述将包括痴呆症患者的家庭照护者,不论其年龄、性别或种族,他们在整个研究过程中都积极参与了研究。此外,任何国家的英语和德语证据来源均可纳入。资料来源将由两名独立审查员进行筛选。研究结果将使用量身定制的图表工具进行提取,并根据研究问题和目标在最终报告中进行阐述:讨论:开发一种量身定制的方法,让痴呆症患者的家庭照顾者参与研究和开发,这对科学界和目标群体本身都具有深远的意义:开放科学框架 https://doi.org/10.17605/OSF.IO/PMZYV 。
{"title":"Involvement of family caregivers in dementia care research: a scoping review protocol.","authors":"Franziska Anushi Jagoda, Julian Hirt, Claudia Mueller, Margareta Halek","doi":"10.1186/s13643-024-02696-w","DOIUrl":"10.1186/s13643-024-02696-w","url":null,"abstract":"<p><strong>Background: </strong>Family caregivers of people with dementia are a distinct group due to the particularly stressful and time-intensive care situation at home. Despite these challenges, involving them in research is crucial to better understand and address their specific needs. However, little evidence exists regarding a tailored approach for researchers for this group considering their situation at home.</p><p><strong>Methods: </strong>A scoping review will be conducted following the Joanna Briggs Institute methodological guidance, including the databases MEDLINE (PubMed), CINAHL, Scopus (Elsevier), and PsycINFO (EBSCO). The review will include family caregivers of people with dementia, regardless of age, gender, or ethnicity, who have been actively involved in research throughout the research process. Moreover, sources of evidence from any country in both English and German are eligible for inclusion. Sources will be screened by two independent reviewers. Results will be extracted using a tailored charting tool and presented in the final report according to the research questions and objectives.</p><p><strong>Discussion: </strong>Developing a tailored approach to involve family caregivers of people with dementia in research and development has profound importance to both the scientific community and the target group itself.</p><p><strong>Systematic review registration: </strong>Open Science Framework https://doi.org/10.17605/OSF.IO/PMZYV .</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"13 1","pages":"277"},"PeriodicalIF":6.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stem cell therapy for non-ischemic dilated cardiomyopathy: a systematic review and meta-analysis. 干细胞治疗非缺血性扩张型心肌病:系统综述与荟萃分析。
IF 6.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-08 DOI: 10.1186/s13643-024-02701-2
Shiyi Tao, Lintong Yu, Jun Li, Ji Wu, Deshuang Yang, Tiantian Xue, Lanxin Zhang, Zicong Xie, Xuanchun Huang
<p><strong>Background: </strong>Stem cell therapy is the transplantation of human cells to aid the healing of damaged or wounded tissues and cells. Only a few small-scale trials have been conducted to investigate stem cell therapy for non-ischemic dilated cardiomyopathy (DCM). We aimed to perform a systematic review and meta-analysis to assess the efficacy and safety of stem cell therapy for DCM.</p><p><strong>Methods: </strong>A comprehensive search of the databases of PubMed, Embase, Web of Science Core Collection, Cochrane Library, and ProQuest was conducted from their inception to June 30, 2024, to access randomized controlled trials (RCTs) that were centered on stem cell therapy for DCM. The primary outcome was left ventricular ejection fraction (LVEF), and the secondary outcomes included left ventricular end-diastolic dimension (LVEDD), left ventricular end-diastolic volume (LVEDV), 6-min walk test (6MWT), NYHA functional classification, quality of life (QoL) such as Minnesota Living with Heart Failure Questionnaire (MLHFQ) and Kansas City Cardiomyopathy Questionnaire (KCCQ), N-terminal pro-brain natriuretic peptide (NT-proBNP), and VO<sub>2</sub> peak. Moreover, major adverse cardiovascular events (MACEs) were also recorded. The Cochrane risk-of-bias assessment tool was used to evaluate the quality of the included RCTs, and the certainty of the evidence was assessed using the GRADE method. Sensitivity analysis was taken into consideration to determine the stability of the results. This review was registered with PROSPERO (CRD42024568912).</p><p><strong>Results: </strong>Eleven RCTs involving 637 participants were included in the quantitative analysis. The results indicated that there was a significant increase in mean LVEF (MD = 4.84, 95% CI 3.25-6.42, P < 0.00001) and considerable decrease in LVEDV (MD = - 29.51, 95% CI - 58.07 to - 0.95, P = 0.04) and NT-proBNP (MD = - 737.55, 95% CI - 904.28 to - 570.82, P < 0.00001) in DCM patients treated with stem cell therapy compared with controls. Stem cell therapy was also related to the improvement in functional capacity, as evaluated by 6MWT (MD = 44.32, 95% CI 34.70 - 53.94, P < 0.00001) and NYHA functional classification (MD = - 0.63, 95% CI - 0.96 to - 0.30, P = 0.0002). It also had positive effects on improving QoL, including significantly decreasing MLHFQ score (MD = - 16.60, 95% CI - 26.57 to - 6.63, P = 0.001) and increasing the KCCQ score (MD = 14.76, 95% CI 7.76 - 21.76, P < 0.0001). No significant differences were observed in LVEDD, VO<sub>2</sub> peak, and MACEs between the two groups. The GRADE analysis revealed that the evidence was graded from low to moderate. Sensitivity analysis of the results suggested that the results were stable.</p><p><strong>Conclusion: </strong>The systematic review and meta-analysis indicates that stem cell therapy may be an effective and safe approach to improve cardiac function and quality of life in DCM patients. Nevertheless, given the limitations of
背景:干细胞疗法是通过移植人体细胞来帮助受损或受伤组织和细胞的愈合。目前只有少数几项小规模试验研究了干细胞治疗非缺血性扩张型心肌病(DCM)。我们旨在进行系统性回顾和荟萃分析,评估干细胞疗法治疗DCM的有效性和安全性:方法:我们对PubMed、Embase、Web of Science Core Collection、Cochrane Library和ProQuest等数据库进行了全面检索,检索时间从开始到2024年6月30日,以获取以干细胞治疗DCM为中心的随机对照试验(RCT)。主要结果为左心室射血分数(LVEF),次要结果包括左心室舒张末期尺寸(LVEDD)、左心室舒张末期容积(LVEDV)、6分钟步行测试(6MWT)、NYHA功能分级、生活质量(QoL)(如明尼苏达心力衰竭生活问卷(MLHFQ)和堪萨斯城心肌病问卷(KCCQ))、N-末端前脑钠尿肽(NT-proBNP)和VO2峰值。此外,还记录了主要不良心血管事件(MACE)。采用 Cochrane 偏倚风险评估工具对纳入的 RCT 进行质量评估,并采用 GRADE 方法对证据的确定性进行评估。为确定结果的稳定性,还进行了敏感性分析。本综述已在 PROSPERO 注册(CRD42024568912):定量分析纳入了 11 项 RCT,涉及 637 名参与者。结果表明,两组患者的平均 LVEF(MD = 4.84,95% CI 3.25-6.42,P 2 峰值)和 MACEs 均显著增加。GRADE 分析显示,证据等级从低到中。对结果的敏感性分析表明,结果是稳定的:系统综述和荟萃分析表明,干细胞疗法可能是改善DCM患者心脏功能和生活质量的一种有效而安全的方法。尽管如此,鉴于现有研究的局限性,需要更大规模、设计良好的RCT研究来证实和支持我们的发现。
{"title":"Stem cell therapy for non-ischemic dilated cardiomyopathy: a systematic review and meta-analysis.","authors":"Shiyi Tao, Lintong Yu, Jun Li, Ji Wu, Deshuang Yang, Tiantian Xue, Lanxin Zhang, Zicong Xie, Xuanchun Huang","doi":"10.1186/s13643-024-02701-2","DOIUrl":"10.1186/s13643-024-02701-2","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Stem cell therapy is the transplantation of human cells to aid the healing of damaged or wounded tissues and cells. Only a few small-scale trials have been conducted to investigate stem cell therapy for non-ischemic dilated cardiomyopathy (DCM). We aimed to perform a systematic review and meta-analysis to assess the efficacy and safety of stem cell therapy for DCM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A comprehensive search of the databases of PubMed, Embase, Web of Science Core Collection, Cochrane Library, and ProQuest was conducted from their inception to June 30, 2024, to access randomized controlled trials (RCTs) that were centered on stem cell therapy for DCM. The primary outcome was left ventricular ejection fraction (LVEF), and the secondary outcomes included left ventricular end-diastolic dimension (LVEDD), left ventricular end-diastolic volume (LVEDV), 6-min walk test (6MWT), NYHA functional classification, quality of life (QoL) such as Minnesota Living with Heart Failure Questionnaire (MLHFQ) and Kansas City Cardiomyopathy Questionnaire (KCCQ), N-terminal pro-brain natriuretic peptide (NT-proBNP), and VO&lt;sub&gt;2&lt;/sub&gt; peak. Moreover, major adverse cardiovascular events (MACEs) were also recorded. The Cochrane risk-of-bias assessment tool was used to evaluate the quality of the included RCTs, and the certainty of the evidence was assessed using the GRADE method. Sensitivity analysis was taken into consideration to determine the stability of the results. This review was registered with PROSPERO (CRD42024568912).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Eleven RCTs involving 637 participants were included in the quantitative analysis. The results indicated that there was a significant increase in mean LVEF (MD = 4.84, 95% CI 3.25-6.42, P &lt; 0.00001) and considerable decrease in LVEDV (MD = - 29.51, 95% CI - 58.07 to - 0.95, P = 0.04) and NT-proBNP (MD = - 737.55, 95% CI - 904.28 to - 570.82, P &lt; 0.00001) in DCM patients treated with stem cell therapy compared with controls. Stem cell therapy was also related to the improvement in functional capacity, as evaluated by 6MWT (MD = 44.32, 95% CI 34.70 - 53.94, P &lt; 0.00001) and NYHA functional classification (MD = - 0.63, 95% CI - 0.96 to - 0.30, P = 0.0002). It also had positive effects on improving QoL, including significantly decreasing MLHFQ score (MD = - 16.60, 95% CI - 26.57 to - 6.63, P = 0.001) and increasing the KCCQ score (MD = 14.76, 95% CI 7.76 - 21.76, P &lt; 0.0001). No significant differences were observed in LVEDD, VO&lt;sub&gt;2&lt;/sub&gt; peak, and MACEs between the two groups. The GRADE analysis revealed that the evidence was graded from low to moderate. Sensitivity analysis of the results suggested that the results were stable.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The systematic review and meta-analysis indicates that stem cell therapy may be an effective and safe approach to improve cardiac function and quality of life in DCM patients. Nevertheless, given the limitations of ","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"13 1","pages":"276"},"PeriodicalIF":6.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11546504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The efficacy and safety of ketorolac for postoperative pain management in lumbar spine surgery: a meta-analysis of randomized controlled trials. 酮咯酸治疗腰椎手术术后疼痛的有效性和安全性:随机对照试验荟萃分析。
IF 6.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-05 DOI: 10.1186/s13643-024-02685-z
Jianbin Guan, Ningning Feng, Kaitan Yang, Haimiti Abudouaini, Peng Liu
<p><strong>Background: </strong>Ketorolac is widely utilized for postoperative pain management, including back pain after lumbar spinal surgery. Several trials have assessed the efficacy of Ketorolac alone and in combination with other analgesics such as bupivacaine, morphine, epinephrine, paracetamol, and pregabalin. However, the effects and safety profile of ketorolac in these contexts remain controversial.</p><p><strong>Objective: </strong>We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of Ketorolac administration, both as a monotherapy and in combination with other analgesics, for managing postoperative pain in adults undergoing lumbar spinal surgery.</p><p><strong>Methods: </strong>We searched PubMed, EMbase, Web of Science, EBSCO, CNKI, WanFang, VIP, and Cochrane library databases through July 2024 for randomized controlled trials (RCTs) assessing the analgesic efficacy of Ketorolac administration for postoperative pain of lumbar surgery. The meta-analysis was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statements. Data were extracted and analyzed using open-source meta-analysis software OpenMeta-Analyst, focusing on outcomes such as VAS pain scores, postoperative morphine requirements (PMR), length of hospital stay (LOS), and adverse effects, such as nausea, vomiting, pruritus, and constipation. The quality of evidence was assessed using the Jada scale.</p><p><strong>Results: </strong>Thirteen RCTs comprising a total of 938 patients were included. The methodological quality of the studies was high, with three studies scoring 5, six studies scoring 4, and four studies scoring 3 on the Jadad scale. Ketorolac significantly reduced pain compared to controls at 0-6 h, with a mean difference (MD) of - 1.42 (95% CI: - 2.03 to - 0.80; P < 0.0001), exceeding the Minimal Clinically Important Difference (MCID) of 1.2 to 2.0 points on the Visual Analog Scale (VAS), indicating clinically meaningful pain relief. During the 6-12-h period, the pain reduction was significant (MD =  - 0.58; 95% CI: - 0.80 to - 0.35; P < 0.0001), though below the MCID threshold. In the 12-24-h period, Ketorolac continued to show significant pain reduction (MD =  - 0.48; 95% CI: - 0.68 to - 0.28; P < 0.0001), but this reduction was also below the MCID. Heterogeneity was low in the 12-24-h period (I<sup>2</sup> = 13%), indicating consistent results across studies. There was a significant reduction in PMR (SMD =  - 1.83; 95% CI =  - 3.42 to - 0.23; P < 0.0001), although with considerable heterogeneity among the studies (I<sup>2</sup> = 93%, heterogeneity P < 0.01). Ketorolac administration also significantly reduced the LOS compared to controls (MD =  - 0.45 days; 95% CI =  - 0.74 to - 0.16; P = 0.0001), though this reduction, which is less than a full day (0.45 days), may have limited clinical significance. The findings suggest that Ketorolac ef
背景:开托拉克被广泛用于术后疼痛治疗,包括腰椎手术后的背痛。多项试验评估了酮咯酸单独使用或与布比卡因、吗啡、肾上腺素、扑热息痛和普瑞巴林等其他镇痛药联合使用的疗效。然而,酮咯酸在这些情况下的效果和安全性仍存在争议:我们对随机对照试验(RCTs)进行了系统回顾和荟萃分析,以评估酮咯酸作为单药或与其他镇痛药联合应用治疗成人腰椎手术术后疼痛的有效性和安全性:截至 2024 年 7 月,我们在 PubMed、EMbase、Web of Science、EBSCO、CNKI、万方、VIP 和 Cochrane 图书馆数据库中检索了评估酮咯酸治疗腰椎手术术后疼痛的镇痛效果的随机对照试验 (RCT)。荟萃分析按照系统综述和荟萃分析首选报告项目(PRISMA)声明进行。使用开源荟萃分析软件 OpenMeta-Analyst 对数据进行提取和分析,重点关注 VAS 疼痛评分、术后吗啡需求量(PMR)、住院时间(LOS)以及恶心、呕吐、瘙痒和便秘等不良反应。证据质量采用 Jada 量表进行评估:结果:共纳入了 13 项 RCT 研究,包括 938 名患者。这些研究的方法学质量较高,其中 3 项研究的 Jadad 评分为 5 分,6 项研究的 Jadad 评分为 4 分,4 项研究的 Jadad 评分为 3 分。与对照组相比,酮咯酸能明显减轻0-6小时的疼痛,平均差(MD)为-1.42(95% CI:-2.03 至 -0.80;P 2 = 13%),表明各研究结果一致。PMR 明显下降(SMD = - 1.83;95% CI = - 3.42 至 - 0.23;P 2 = 93%,异质性 P 结论:无论是单独使用还是与其他镇痛药联合使用,酮咯酸都能有效减轻成人腰椎手术后的疼痛并减少阿片类药物的用量。与其他镇痛药或安慰剂相比,酮咯酸不会明显增加术后恶心和呕吐的发生率。虽然酮咯酸还能缩短手术时间,但其临床意义不大。然而,研究设计、剂量和联合疗法的差异性导致了结果的显著异质性。未来的研究应侧重于规范方案和探索最佳剂量策略。此外,还需要进行长期的安全性和有效性研究,以更好地了解酮咯酸在术后疼痛治疗中的作用。
{"title":"The efficacy and safety of ketorolac for postoperative pain management in lumbar spine surgery: a meta-analysis of randomized controlled trials.","authors":"Jianbin Guan, Ningning Feng, Kaitan Yang, Haimiti Abudouaini, Peng Liu","doi":"10.1186/s13643-024-02685-z","DOIUrl":"10.1186/s13643-024-02685-z","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Ketorolac is widely utilized for postoperative pain management, including back pain after lumbar spinal surgery. Several trials have assessed the efficacy of Ketorolac alone and in combination with other analgesics such as bupivacaine, morphine, epinephrine, paracetamol, and pregabalin. However, the effects and safety profile of ketorolac in these contexts remain controversial.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of Ketorolac administration, both as a monotherapy and in combination with other analgesics, for managing postoperative pain in adults undergoing lumbar spinal surgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We searched PubMed, EMbase, Web of Science, EBSCO, CNKI, WanFang, VIP, and Cochrane library databases through July 2024 for randomized controlled trials (RCTs) assessing the analgesic efficacy of Ketorolac administration for postoperative pain of lumbar surgery. The meta-analysis was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statements. Data were extracted and analyzed using open-source meta-analysis software OpenMeta-Analyst, focusing on outcomes such as VAS pain scores, postoperative morphine requirements (PMR), length of hospital stay (LOS), and adverse effects, such as nausea, vomiting, pruritus, and constipation. The quality of evidence was assessed using the Jada scale.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Thirteen RCTs comprising a total of 938 patients were included. The methodological quality of the studies was high, with three studies scoring 5, six studies scoring 4, and four studies scoring 3 on the Jadad scale. Ketorolac significantly reduced pain compared to controls at 0-6 h, with a mean difference (MD) of - 1.42 (95% CI: - 2.03 to - 0.80; P &lt; 0.0001), exceeding the Minimal Clinically Important Difference (MCID) of 1.2 to 2.0 points on the Visual Analog Scale (VAS), indicating clinically meaningful pain relief. During the 6-12-h period, the pain reduction was significant (MD =  - 0.58; 95% CI: - 0.80 to - 0.35; P &lt; 0.0001), though below the MCID threshold. In the 12-24-h period, Ketorolac continued to show significant pain reduction (MD =  - 0.48; 95% CI: - 0.68 to - 0.28; P &lt; 0.0001), but this reduction was also below the MCID. Heterogeneity was low in the 12-24-h period (I&lt;sup&gt;2&lt;/sup&gt; = 13%), indicating consistent results across studies. There was a significant reduction in PMR (SMD =  - 1.83; 95% CI =  - 3.42 to - 0.23; P &lt; 0.0001), although with considerable heterogeneity among the studies (I&lt;sup&gt;2&lt;/sup&gt; = 93%, heterogeneity P &lt; 0.01). Ketorolac administration also significantly reduced the LOS compared to controls (MD =  - 0.45 days; 95% CI =  - 0.74 to - 0.16; P = 0.0001), though this reduction, which is less than a full day (0.45 days), may have limited clinical significance. The findings suggest that Ketorolac ef","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"13 1","pages":"275"},"PeriodicalIF":6.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Semi-automated title-abstract screening using natural language processing and machine learning. 利用自然语言处理和机器学习进行标题-摘要半自动筛选。
IF 6.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.1186/s13643-024-02688-w
Maximilian Pilz, Samuel Zimmermann, Juliane Friedrichs, Enrica Wördehoff, Ulrich Ronellenfitsch, Meinhard Kieser, Johannes A Vey

Background: Title-abstract screening in the preparation of a systematic review is a time-consuming task. Modern techniques of natural language processing and machine learning might allow partly automatization of title-abstract screening. In particular, clear guidance on how to proceed with these techniques in practice is of high relevance.

Methods: This paper presents an entire pipeline how to use natural language processing techniques to make the titles and abstracts usable for machine learning and how to apply machine learning algorithms to adequately predict whether or not a publication should be forwarded to full text screening. Guidance for the practical use of the methodology is given.

Results: The appealing performance of the approach is demonstrated by means of two real-world systematic reviews with meta analysis.

Conclusions: Natural language processing and machine learning can help to semi-automatize title-abstract screening. Different project-specific considerations have to be made for applying them in practice.

背景:编写系统综述时的标题-摘要筛选是一项耗时的工作。现代自然语言处理和机器学习技术可使标题-摘要筛选部分自动化。特别是,如何在实践中使用这些技术的明确指导具有重要意义:本文介绍了如何使用自然语言处理技术使标题和摘要可用于机器学习,以及如何应用机器学习算法充分预测出版物是否应转入全文筛选的整个流程。此外,还给出了该方法的实际使用指南:结果:通过两篇真实世界的系统综述和元分析,展示了该方法的吸引力:自然语言处理和机器学习有助于实现标题-摘要筛选的半自动化。在实际应用中,必须针对具体项目做出不同的考虑。
{"title":"Semi-automated title-abstract screening using natural language processing and machine learning.","authors":"Maximilian Pilz, Samuel Zimmermann, Juliane Friedrichs, Enrica Wördehoff, Ulrich Ronellenfitsch, Meinhard Kieser, Johannes A Vey","doi":"10.1186/s13643-024-02688-w","DOIUrl":"10.1186/s13643-024-02688-w","url":null,"abstract":"<p><strong>Background: </strong>Title-abstract screening in the preparation of a systematic review is a time-consuming task. Modern techniques of natural language processing and machine learning might allow partly automatization of title-abstract screening. In particular, clear guidance on how to proceed with these techniques in practice is of high relevance.</p><p><strong>Methods: </strong>This paper presents an entire pipeline how to use natural language processing techniques to make the titles and abstracts usable for machine learning and how to apply machine learning algorithms to adequately predict whether or not a publication should be forwarded to full text screening. Guidance for the practical use of the methodology is given.</p><p><strong>Results: </strong>The appealing performance of the approach is demonstrated by means of two real-world systematic reviews with meta analysis.</p><p><strong>Conclusions: </strong>Natural language processing and machine learning can help to semi-automatize title-abstract screening. Different project-specific considerations have to be made for applying them in practice.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"13 1","pages":"274"},"PeriodicalIF":6.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stroke patient and stakeholder engagement (SPSE): concepts, definitions, models, implementation strategies, indicators, and frameworks-a systematic scoping review. 卒中患者和利益相关者参与(SPSE):概念、定义、模式、实施策略、指标和框架--系统性范围界定综述。
IF 6.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 DOI: 10.1186/s13643-024-02686-y
Hamidreza Khankeh, Gordon Guyatt, Shima Shirozhan, Juliet Roudini, Torsten Rackoll, Ulrich Dirnagl

Background: Involving stroke patients in clinical research through patient engagement aims to ensure that studies are patient-centered, and may help ensure they are feasible, ethical, and credible, ultimately leading to enhanced trust and communication between researchers and the patient community. In this study, we have conducted a scoping review to identify existing evidence and gaps in SPSE.

Methods: The five-step approach outlined by Arksey and O'Malley, in conjunction with the Preferred Reporting Items for Scoping Reviews (PRISMA-ScR) guidelines, provided the structure for this review. To find relevant articles, we searched PubMed, Web of Science, and Embase databases up to February 2024. Additionally, the review team conducted a hand search using Google Scholar, key journals, and references of highly relevant articles. Reviewers screened articles, selecting eligible English-language ones with available full texts, and extracted data from them into a pre-designed table tested by the research team.

Result: Of the 1002 articles initially identified, 21 proved eligible. Stakeholder engagement primarily occurred during the design phase of studies and within the studies using qualitative methodologies. Although the engagement of stakeholders in the research process is increasing, practice regarding terminology and principles of implementation remains variable. Researchers have recognized the benefits of stakeholder engagement, but have also faced numerous challenges that often arise during the research process.

Conclusion: The current study identifies stakeholder groups and the benefits and challenges researchers face in implementing their engagement. Given existing challenges and limited specific models or frameworks, it is suggested to explore applied recommendations for stakeholder engagement in future studies, that may enhance stakeholder engagement, overcome obstacles, and unify researchers' understanding of engagement and implementation.

背景:通过患者参与让卒中患者参与临床研究旨在确保研究以患者为中心,并有助于确保研究的可行性、伦理性和可信性,最终增强研究者与患者群体之间的信任和沟通。在本研究中,我们进行了一次范围审查,以确定 SPSE 的现有证据和差距:方法:Arksey 和 O'Malley 概述的五步方法与范围界定综述首选报告项目 (PRISMA-ScR) 指南相结合,为本综述提供了结构。为了找到相关文章,我们检索了截止到 2024 年 2 月的 PubMed、Web of Science 和 Embase 数据库。此外,综述小组还使用谷歌学术、主要期刊和高度相关文章的参考文献进行了人工搜索。审稿人对文章进行了筛选,挑选出符合条件且有全文的英文文章,并将其中的数据提取到研究小组预先设计好的表格中进行测试:结果:在最初确定的 1002 篇文章中,有 21 篇符合条件。利益相关者的参与主要发生在研究的设计阶段和采用定性方法的研究中。虽然利益相关者在研究过程中的参与度在不断提高,但在术语和实施原则方面的做法仍不尽相同。研究人员已经认识到利益相关者参与的益处,但也面临着研究过程中经常出现的诸多挑战:本研究确定了利益相关者群体以及研究人员在实施参与过程中面临的益处和挑战。鉴于现有的挑战和有限的具体模式或框架,建议在今后的研究中探索利益相关者参与的应用建议,以加强利益相关者的参与、克服障碍并统一研究人员对参与和实施的理解。
{"title":"Stroke patient and stakeholder engagement (SPSE): concepts, definitions, models, implementation strategies, indicators, and frameworks-a systematic scoping review.","authors":"Hamidreza Khankeh, Gordon Guyatt, Shima Shirozhan, Juliet Roudini, Torsten Rackoll, Ulrich Dirnagl","doi":"10.1186/s13643-024-02686-y","DOIUrl":"10.1186/s13643-024-02686-y","url":null,"abstract":"<p><strong>Background: </strong>Involving stroke patients in clinical research through patient engagement aims to ensure that studies are patient-centered, and may help ensure they are feasible, ethical, and credible, ultimately leading to enhanced trust and communication between researchers and the patient community. In this study, we have conducted a scoping review to identify existing evidence and gaps in SPSE.</p><p><strong>Methods: </strong>The five-step approach outlined by Arksey and O'Malley, in conjunction with the Preferred Reporting Items for Scoping Reviews (PRISMA-ScR) guidelines, provided the structure for this review. To find relevant articles, we searched PubMed, Web of Science, and Embase databases up to February 2024. Additionally, the review team conducted a hand search using Google Scholar, key journals, and references of highly relevant articles. Reviewers screened articles, selecting eligible English-language ones with available full texts, and extracted data from them into a pre-designed table tested by the research team.</p><p><strong>Result: </strong>Of the 1002 articles initially identified, 21 proved eligible. Stakeholder engagement primarily occurred during the design phase of studies and within the studies using qualitative methodologies. Although the engagement of stakeholders in the research process is increasing, practice regarding terminology and principles of implementation remains variable. Researchers have recognized the benefits of stakeholder engagement, but have also faced numerous challenges that often arise during the research process.</p><p><strong>Conclusion: </strong>The current study identifies stakeholder groups and the benefits and challenges researchers face in implementing their engagement. Given existing challenges and limited specific models or frameworks, it is suggested to explore applied recommendations for stakeholder engagement in future studies, that may enhance stakeholder engagement, overcome obstacles, and unify researchers' understanding of engagement and implementation.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"13 1","pages":"271"},"PeriodicalIF":6.3,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward a whole-of-virtual school framework for promoting student physical activity: a scoping review protocol. 促进学生体育活动的全虚拟学校框架:范围界定审查协议。
IF 6.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 DOI: 10.1186/s13643-024-02689-9
Chad M Killian, Eugenia Opuda, Collin A Webster, Taemin Ha, Brian Dauenhauer, Jennifer M Krause

Background: The advent of full-time virtual schooling presents unique challenges and opportunities for the promotion of physical activity (PA) among children and adolescents. Despite the recognized benefits of PA as an essential component for combating non-communicable diseases and ensuring holistic development, there is a notable gap in understanding how to effectively integrate PA within the digital learning environments of full-time virtual schools. Current efforts to promote student PA are targeted for implementation exclusively in contexts characterized by physical school campuses that are bound to their surrounding local communities. This is problematic given the digital, widely distributed, and contextually unmoored nature of virtual schooling. Our aim in this scoping review is to advance research on whole-of-school physical activity promotion within full-time virtual schools by examining the published literature on whole-of-school PA promotion within full-time virtual schools. Specifically, this review will map the literature, consolidate knowledge claims and practical implications, and identify evidence gaps that merit further investigation.

Methods/design: This review will be conducted using evidence-informed scoping review methodology and reporting guidelines. Articles will be included if they are peer-reviewed English-language research, commentary, practical, or grey literature and relate to the participation, support, design, development, and/or provision of remote online PA interventions delivered through primary/elementary and/or secondary/middle school/high schools. Searches will be conducted in PsycInfo, ERIC, SportDiscus, and Web of Science. Additional hand-searching, reference scans, and grey literature searches will also be performed. Two trained research assistants will independently complete study screening and selection and data charting with guidance from a senior author. Charted data will be displayed in table form, and depending on the results, data will also be synthesized through qualitative content analysis using the Active Schools guiding framework as an analytical and interpretive lens.

Discussion: This scoping review will serve as a guidepost for the application and advancement of research on whole-of-school PA promotion through full-time virtual schools. The results will address the increased importance of equitable online learning and PA promotion due to the expanding virtual education landscape, with implications for public health and education policy.

Systematic review registration: Open Science Framework:  https://osf.io/f6wau/ .

背景:全日制虚拟学校的出现为促进儿童和青少年的体育锻炼(PA)带来了独特的挑战和机遇。尽管体育锻炼是防治非传染性疾病和确保全面发展的重要组成部分,其益处已得到公认,但在如何将体育锻炼有效融入全日制虚拟学校的数字化学习环境方面仍存在明显差距。目前,促进学生体育锻炼的工作仅针对以实体校园为特点的实施环境,而实体校园又与周围的当地社区紧密相连。考虑到虚拟学校教育的数字化、广泛分布和与环境无关的性质,这种做法是有问题的。我们本次范围界定综述的目的是,通过研究已发表的有关在全日制虚拟学校内促进全校体育活动的文献,推动有关在全日制虚拟学校内促进全校体育活动的研究。具体而言,本综述将绘制文献地图,整合知识主张和实际影响,并确定值得进一步调查的证据缺口:本综述将采用循证范围界定综述方法和报告指南。如果文章是经同行评审的英文研究、评论、实践或灰色文献,且与通过小学/初级和/或中学/初中/高中提供的远程在线 PA 干预的参与、支持、设计、开发和/或提供有关,则将被纳入。检索将在 PsycInfo、ERIC、SportDiscus 和 Web of Science 中进行。此外,还将进行手工检索、参考文献扫描和灰色文献检索。两名训练有素的研究助理将在资深作者的指导下独立完成研究筛选和数据图表制作。图表数据将以表格形式显示,根据结果,还将使用 "积极学校 "指导框架作为分析和解释视角,通过定性内容分析对数据进行综合:本范围综述将为通过全日制虚拟学校促进全校 PA 研究的应用和发展提供指导。研究结果将探讨由于虚拟教育领域的不断扩大,公平在线学习和 PA 促进的重要性日益增加,对公共卫生和教育政策产生的影响:开放科学框架:https://osf.io/f6wau/ 。
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引用次数: 0
The distribution of work-related musculoskeletal disorders among nurses in sub-Saharan Africa: a scoping review. 撒哈拉以南非洲护士中与工作有关的肌肉骨骼疾病的分布情况:范围界定审查。
IF 6.3 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 DOI: 10.1186/s13643-024-02687-x
Kagiso Kgakge, Mbuzeleni Hlongwa, Ugochinyere Ijeoma Nwagbara, Themba Ginindza

Background: Musculoskeletal injuries are noticeably high among the nursing fraternity, with lower back pain (LBP) being the most prevalent. Therefore, this study aimed to map evidence on the burden of occupational musculoskeletal disorders (MSD) among nurses in sub-Saharan Africa (SSA).

Methods: This scoping review was guided by Arksey and O'Malley's framework. We conducted a comprehensive literature search with no date limit from the following databases: Science Direct, PubMed, Sabinet (SA ePublications), EBSCOhost platform, World Health Organization (WHO) Library, Google Scholar, SCOPUS, Taylor and Francis, and WorldCat Academic Search with full text for published studies. The search took place from May 2022 to December 2022. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was used for reporting the search results, and a thematic content analysis was used to present the emerging themes from the included studies.

Results: A total of 16,714 studies were identified after the database search. Only 29 studies met the inclusion criteria after full-article screening and were included for data extraction. The studies reported a total of 6343 participants from different regions in SSA. The 29 included studies showed evidence on the prevalence of MSD, associated risk factors of MSD and LBP among nurses in SSA with some recommendations on how to reduce the prevalence of MSD among nurses.

Conclusion: The study findings reveal that there is a high prevalence of MSD among nurses, especially LBP. The etiology of MSD among nurses is multifactorial, and multifaceted strategies to address MSD are recommended. Further research is recommended to explore strategies that can be used to curb the high prevalence of MSD among nurses.

背景:在护士群体中,肌肉骨骼损伤的发病率明显较高,其中以腰背痛(LBP)最为普遍。因此,本研究旨在绘制撒哈拉以南非洲(SSA)护士职业性肌肉骨骼疾病(MSD)负担的证据图:本次范围界定审查以 Arksey 和 O'Malley 的框架为指导。我们在以下数据库中进行了无日期限制的全面文献检索:Science Direct、PubMed、Sabinet (SA ePublications)、EBSCOhost 平台、世界卫生组织 (WHO) 图书馆、Google Scholar、SCOPUS、Taylor and Francis 和 WorldCat Academic Search(含已发表研究的全文)。检索时间为 2022 年 5 月至 2022 年 12 月。在报告检索结果时使用了系统综述和元分析首选报告项目(PRISMA),并使用了主题内容分析法来呈现所纳入研究的新主题:结果:经过数据库检索,共确定了 16714 项研究。经过全文筛选,只有 29 项研究符合纳入标准,并被纳入数据提取范围。这些研究共报告了来自撒哈拉以南非洲不同地区的 6343 名参与者。纳入的 29 项研究显示了 SSA 地区护士中 MSD 患病率、MSD 相关风险因素和 LBP 的证据,并就如何降低护士中 MSD 患病率提出了一些建议:研究结果表明,护士的 MSD 患病率很高,尤其是枸杞多糖症。护士 MSD 的病因是多因素的,建议采取多方面的策略来解决 MSD 问题。建议开展进一步研究,探索可用于遏制护士中 MSD 高流行率的策略。
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引用次数: 0
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