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The Importance of Digital Lung Tomosynthesis in Overcoming Computed-Tomography-to-Body Divergence During Bronchoscopic Biopsies of Peripheral Lung Nodules. 数字肺断层成像在克服支气管镜活检外周肺结节时计算机断层成像与身体偏离的重要性
IF 0.8 Q4 SURGERY Pub Date : 2024-07-15 DOI: 10.52198/24.STI.44.CV1813
Amit Bobby Mahajan, Joseph Cicenia, Douglas K Hogarth, Omar Ibrahim, Tao Zhao, Krish Badra

The advent of robotic bronchoscopy coupled with electromagnetic navigation bronchoscopy (EMN) and shape-sensing technology have increased diagnostic yields for peripheral pulmonary nodules compared to traditional bronchoscopy. Yet, diagnostic yields from these bronchoscopic platforms still fall short of where they should be. This shortfall is in large part due to a lack of advanced imaging during peripheral bronchoscopy and computed tomography (CT)-to-body divergence (CTBD). Digital lung tomosynthesis (DLT) is an advanced imaging modality that helps overcome CTBD during bronchoscopic biopsies of lung nodules. DLT is a quasi-3D imaging technique, which reconstructs tomographic images of the lung from a series of 2D fluoroscopic projection images. These images can be acquired either using a digital flat panel fluoroscopy machine or a fluoroscopy machine with a more traditional image-intensifier present in most standard bronchoscopy suites. This review aims to explain the mechanisms of both CTBD and DLT to help diagnose early-stage lung cancer more effectively.

与传统支气管镜相比,机器人支气管镜的出现加上电磁导航支气管镜(EMN)和形状传感技术提高了外周肺结节的诊断率。然而,这些支气管镜平台的诊断率仍未达到应有的水平。这种不足在很大程度上是由于外周支气管镜检查和计算机断层扫描(CT)-体层扫描(CTBD)过程中缺乏先进的成像技术。数字肺断层合成(DLT)是一种先进的成像模式,有助于克服支气管镜肺结节活检过程中的 CTBD。DLT 是一种准三维成像技术,可通过一系列二维透视投影图像重建肺部断层图像。这些图像可以通过数字平板透视机或大多数标准支气管镜检查套件中带有更传统图像增强器的透视机获得。本综述旨在解释 CTBD 和 DLT 的机制,以帮助更有效地诊断早期肺癌。
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引用次数: 0
Meniscal Repair with ArthroZheal® an Autologous Bioactive Fibrin Scaffold. A New Technique and Treatment Option. 用自体生物活性纤维蛋白支架 ArthroZheal® 进行半月板修复。一种新的技术和治疗方案。
IF 0.8 Q4 SURGERY Pub Date : 2024-07-15 DOI: 10.52198/24.STI.44.OS1783
George A Skarpas, Konstantinos Maniatis, Nikolaos Barmpounakis, Georgios Kakavas

Injuries of the meniscus often lead to changes in joint biomechanics, which affect the load distribution and contact stresses. The menisci consist of a peripheral vascular region (red zone) and an inner avascular region (white zone). The blood supply plays an important role in the healing of meniscal tears. Surgical treatment of such lesions includes meniscectomy/meniscoplasty and repair, depending on the type of injury, where "meniscoplasty" refers to the treatment modality that occurs under coblation. The application of Autologous Bioactive Matrix (ABM) has been shown to promote healing in such lesions. In addition, a special type of PRF (ArthroZheal®, Vivostat A/S, Allerød, Denmark) has been demonstrated to have healing effects in extracellular matrix synthesis and cell proliferation, as well as regenerative and remodeling effects. This autologous product can be applied directly at the meniscal repair site. We performed a prospective study on meniscus repair with ArthroZheal® alone (plus meniscoplasty) and ArthroZheal® together with an all-inside suturing technique using the STAR AccurFix Meniscal Repair Device system (STAR Sports Medicine, Beijing, China), depending on the type and the site of the lesion. One hundred twenty knees (110 patients) were identified through the use of clinical examination and MRI scan. The study took place between January 2023 and August 2023. Two groups were created: GROUP A was treated only with ArthroZheal®(plus meniscoplasty) and GROUP B was treated with a combination of ArthroZheal® and an all-inside suturing technique (STAR AccurFix). Pre- and postoperative grading was performed with the International Knee Documentation Committee (IKDC) score and the Tegner Activity Level Scale (Tegner Score). The results with both treatment methods were excellent and meniscus restoration has been documented on MRIs conducted 6 months post-op. In 15 patients, 2nd-look arthroscopy was performed through a nanoscope on an outpatient basis, and showed meniscal healing and remodeling. Tegner scores and IKDC scores in both groups showed significant improvement. Meniscal repair should be performed at all costs to maintain meniscal integrity and prevent long-term degenerative changes. New treatment methods include orthobiologics and all-inside suturing techniques. The main idea is to apply an autologous biological scaffold which is able to carry cells into the meniscal lesion and to allow their differentiation, proliferation, and extracellular matrix synthesis to produce a meniscal-like tissue. Our results suggest that the application of autologous ABM (ArthroZheal®) for the treatment of such lesions by means of dry arthroscopy results in better MRI, pain management and functional results at 3 months post-op, and these improvements can persist for up to 6 months.

半月板损伤通常会导致关节生物力学发生变化,从而影响负荷分布和接触应力。半月板由外周血管区(红色区域)和内部无血管区(白色区域)组成。血液供应对半月板撕裂的愈合起着重要作用。根据损伤类型,此类病变的手术治疗包括半月板切除术/半月板成形术和修复术。事实证明,应用自体生物活性基质(ABM)可促进此类损伤的愈合。此外,一种特殊的 PRF(ArthroZheal®,Vivostat A/S,Allerød,丹麦)已被证明在细胞外基质合成和细胞增殖方面具有愈合作用,同时还具有再生和重塑作用。这种自体产品可直接用于半月板修复部位。我们进行了一项前瞻性研究,根据病变的类型和部位,分别采用单独使用 ArthroZheal®(加半月板成形术)和使用 STAR AccurFix 半月板修复装置系统(STAR Sports Medicine,中国北京)的全内侧缝合技术进行半月板修复。通过临床检查和核磁共振扫描,确定了 120 个膝关节(110 名患者)。研究时间为 2023 年 1 月至 2023 年 8 月。研究分为两组:A 组仅采用 ArthroZheal®(加半月板成形术)治疗,B 组采用 ArthroZheal® 和全内侧缝合技术(STAR AccurFix)联合治疗。术前和术后采用国际膝关节文献委员会(IKDC)评分和泰格纳活动度量表(Tegner Score)进行评分。两种治疗方法的效果都很好,术后 6 个月的核磁共振成像显示半月板已经恢复。15 名患者在门诊通过纳米镜进行了第二次关节镜检查,结果显示半月板愈合和重塑。两组患者的Tegner评分和IKDC评分均有明显改善。应不惜一切代价进行半月板修复,以保持半月板的完整性,防止长期退行性病变。新的治疗方法包括骨生物技术和全内侧缝合技术。其主要理念是应用自体生物支架,将细胞带入半月板病变部位,使其分化、增殖并合成细胞外基质,从而产生半月板样组织。我们的研究结果表明,通过干性关节镜应用自体ABM(ArthroZheal®)治疗此类病变,可在术后3个月获得更好的磁共振成像、疼痛控制和功能效果,这些改善可持续6个月。
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引用次数: 0
Outcomes of Femoral Popliteal Bypass in Octogenarians. 八旬老人股骨腘窝搭桥术的疗效
IF 0.8 Q4 SURGERY Pub Date : 2024-07-15 DOI: 10.52198/24.STI.44.CV1793
James Hu, Scott Safir, Ronald Bangiyev, Jonathan Weber, Peter Faries, Ageliki Vouyouka, Paul Lajos

Introduction: Femoral-popliteal bypass (FPB) surgery is a common lower extremity revascularization procedure. As the population continues to age, this procedure is being performed increasingly on older patients. This study investigated whether outcomes differ in this population.

Materials and methods: Patients over and less than 80 years old who underwent FPB between 2009-2013 were queried using an existing hospital registry. Demographics, comorbidities, intraoperative complications, perioperative outcomes, and two-year patencies were compared.

Results: Twenty-four patients in the octogenarian cohort (OC) and 72 patients in the non-octogenarian cohort (NOC) were identified. There was a lower prevalence of smoking (p=0.018) and higher prevalence of hypertension (p=0.021) among octogenarians. Other medical characteristics were similar (p<0.05). There were no differences in use of vein versus PTFE (p=0.002) as a conduit, or above (OC 20.0% vs. NOC 36.7%), versus below knee (OC 80.0% vs. NOC 63.3%) distal anastomosis (p>0.05) between the groups. There was a difference (p<0.01) in indication for procedure (OC/NOC): claudication (0%/44%), limb salvage (71%/31%), and rest pain (29%/25%). There were no differences in 30-day readmissions (17% vs. 21%; p=0.59) or incidence of postoperative (25% vs. 19%; p=0.56) or intraoperative complications (8.3% vs. 4.2%; p=0.52). Length of stay (LOS) was longer and statistically significant in octogenarians (12 days vs. 7 days; p=0.032) and remained significant after multivariate linear regression (p=0.015). Patencies in OC were lower and dropped faster after six months; however, there were no statistically significant differences in patencies at any time interval (p>0.05). The position of the distal anastomosis relative to the knee, conduit type, and indication were not independently predictive of patency outcomes (p>0.05).

Conclusion: The safety and efficacy of FPB in octogenarians is similar to the general population despite LOS in octogenarians being 5.98 days longer. While the difference in indication suggests that vascular surgeons are more conservative in treating octogenarians, our analysis did not reveal significant differences between populations and suggests that lower extremity bypass can be performed safely with comparable results in this cohort. A larger cohort is needed to validate these results.

简介:股-腘旁路(FPB)手术是一种常见的下肢血管重建手术。随着人口的不断老龄化,这种手术越来越多地用于老年患者。本研究调查了这一人群的治疗效果是否有所不同:使用现有的医院登记册对 2009-2013 年间接受 FPB 的 80 岁以上和 80 岁以下的患者进行了调查。比较了人口统计学、合并症、术中并发症、围手术期结果和两年的通畅率:结果:确定了 24 名八旬老人队列(OC)患者和 72 名非八旬老人队列(NOC)患者。八旬老人吸烟率较低(P=0.018),高血压患病率较高(P=0.021)。各组之间的其他医疗特征相似(P0.05)。两组间存在差异(P0.05)。远端吻合口相对于膝关节的位置、导管类型和适应症并不能独立预测通畅结果(P>0.05):结论:尽管八旬老人的LOS延长了5.98天,但FPB在八旬老人中的安全性和有效性与普通人群相似。虽然适应症的差异表明血管外科医生在治疗八旬老人时更为保守,但我们的分析并未发现不同人群之间存在显著差异,这表明在这一人群中可以安全地实施下肢搭桥术,且效果相当。要验证这些结果,还需要更大的群体。
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引用次数: 0
Time to Operation and Mortality Risk in Elderly Patients with Intestinal Fistula: Not Too Early and Not Too Late. 老年肠瘘患者的手术时间和死亡率风险:不能太早,也不能太晚。
IF 0.8 Q4 SURGERY Pub Date : 2024-07-15 DOI: 10.52198/24.STI.44.GS1779
Rahim Hirani, Abbas Smiley, Rifat Latifi

Introduction: This study aimed to ascertain the risk factors contributing to in-patient mortality in elderly patients 65 years and older who were admitted emergently, diagnosed with intestinal fistula, and underwent surgery.

Materials and methods: Data were extracted from the National Inpatient Sample (NIS) spanning the years 2005-2014. Multivariable logistic regression and a generalized additive model (GAM) were employed to investigate predictors of mortality. Continuous variables are presented as mean values with standard deviations (SD).

Results: The study encompassed 34,853 patients with a mean age of 77.7 years-56.5% were female and 79.4% were White. Patients were categorized into three groups based on the time elapsed between admission and surgery: less than two days (17,761), two to three days (8,407), and more than three days (4,233). Mortality rates were 2.7%, 6%, and 6.1% for patients who underwent surgery within two to three days, within two days, and after more than three days of admission, respectively. Notably, the group that operated more than three days from admission experienced nearly double the hospital length of stay (12 days, SD: 7.2) compared to the other two groups (6.3, SD: 6 and 6.1, SD: 4.8). Furthermore, the association between mortality and time to operation, as indicated by the GAM model, revealed a significant non-linear relationship after adjusting for age, gender, race, zip code, hospital location, and comorbidities (p<0.001).

Conclusion: Elderly patients diagnosed with intestinal fistula should undergo operative treatment as soon as possible, once they are resuscitated. Delaying the operation more than three days after admission substantially increases the risk of mortality.

导言本研究旨在确定急诊入院、确诊为肠瘘并接受手术治疗的 65 岁及以上老年患者中导致住院死亡率的风险因素:数据提取自2005-2014年的全国住院病人抽样调查(NIS)。采用多变量逻辑回归和广义相加模型(GAM)研究死亡率的预测因素。连续变量以平均值和标准差(SD)表示:研究涵盖 34853 名患者,平均年龄为 77.7 岁,其中女性占 56.5%,白人占 79.4%。根据患者从入院到手术的时间分为三组:少于两天(17761 人)、两至三天(8407 人)和三天以上(4233 人)。在入院两到三天内、两天内和三天以上接受手术的患者死亡率分别为 2.7%、6% 和 6.1%。值得注意的是,与其他两组(6.3,SD:6 和 6.1,SD:4.8)相比,入院三天以上手术组的住院时间延长了近一倍(12 天,SD:7.2)。此外,GAM 模型显示,在调整年龄、性别、种族、邮政编码、医院位置和合并症后,死亡率与手术时间之间存在显著的非线性关系(p 结论:该研究结果表明,死亡率与手术时间之间存在显著的非线性关系:确诊为肠瘘的老年患者一旦复苏,应尽快接受手术治疗。入院三天后再进行手术会大大增加死亡风险。
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引用次数: 0
The Growing Role of Artificial Intelligence and Technology in Hip and Knee Arthroplasty. 人工智能和技术在髋关节和膝关节置换术中的作用与日俱增。
IF 0.8 Q4 SURGERY Pub Date : 2024-07-15 DOI: 10.52198/24.STI.44.OS1809
Joshua Rainey, Nipun Sodhi, Jeremy M Gililland, Michael A Mont

Artificial intelligence and technology have continued to evolve over recent decades, and their utility in hip and knee arthroplasty is growing with interest and enthusiasm. A multitude of technologies are available to assist surgeons in the intraoperative execution of hip and knee arthroplasty, ranging from robotics and augmented reality to artificial intelligence-powered fluoroscopy. The purpose of this review is to provide a framework for arthroplasty surgeons to understand the concept of artificial intelligence and the advancements in technologies that impact the perioperative care of patients undergoing hip and knee arthroplasty.

近几十年来,人工智能和技术不断发展,人们对其在髋关节和膝关节置换术中的应用越来越感兴趣,热情也与日俱增。从机器人技术和增强现实技术到人工智能驱动的透视技术,有多种技术可用于协助外科医生在术中实施髋关节和膝关节置换术。本综述旨在为关节置换外科医生提供一个框架,帮助他们了解人工智能的概念以及影响髋关节和膝关节置换术患者围手术期护理的先进技术。
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引用次数: 0
The Ross Operation Over 55 Years Later: Comparing Surgical Techniques and Outcomes. 55 年后的罗斯手术:比较手术技术和结果。
IF 0.8 Q4 SURGERY Pub Date : 2024-07-15 DOI: 10.52198/24.STI.44.CV1763
Francesco Nappi

The Ross procedure is often considered the best option for a small group of patients. Some critics argue that harvesting the pulmonary artery again can cause problems, such as exposing the native pulmonary autograft to systemic pressures and requiring further intervention. However, the pulmonary autograft is a living tissue that can adjust to growing conditions and undergo remodelling. The pathophysiology of living tissue, harvesting techniques, indications for use of pulmonary autograft in aortic valve disease, contraindications, and variations of pulmonary autograft as an aortic conduit are discussed in this seminar. Following recent updates from high-volume centres, the indications, contraindications, techniques, and variations of pulmonary autograft as an aortic conduit and, in the absence of substantial well-designed randomised controlled trials, areas where the Ross procedure needs to be reaffirmed as part of the surgical armamentarium are also discussed. Furthermore, increasing evidence suggests that the Ross procedure produces better long-term results than traditional aortic valve replacement in young and middle-aged adults. To enable cardiologists and surgeons to make appropriate decisions for their patients with aortic valve disease, the author provides a complete review of the most recent published studies on the Ross procedure.

罗斯手术通常被认为是一小部分患者的最佳选择。一些批评者认为,再次采集肺动脉可能会导致一些问题,例如使原生肺自体移植物暴露于全身压力下,需要进一步干预。然而,肺自体移植是一种活组织,可以适应生长条件并进行重塑。本次研讨会将讨论活组织的病理生理学、采集技术、肺自体移植用于主动脉瓣疾病的适应症、禁忌症以及肺自体移植作为主动脉导管的变异。根据大容量中心的最新进展,还讨论了肺自体移植作为主动脉导管的适应症、禁忌症、技术和变异,以及在缺乏大量设计良好的随机对照试验的情况下,需要重申罗斯手术作为外科手术手段的一部分的领域。此外,越来越多的证据表明,与传统的主动脉瓣置换术相比,罗斯手术对中青年人的长期疗效更好。为了让心脏病专家和外科医生能够为主动脉瓣疾病患者做出适当的决定,作者对最新发表的有关罗斯手术的研究进行了全面回顾。
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引用次数: 0
A Novel Strategy to Substantially Reduce the Incidence of Periprosthetic Joint Infection Following Total Hip Arthroplasty with Antimicrobial Agents. 使用抗菌剂大幅降低全髋关节置换术后假体周围感染发生率的新策略。
IF 0.8 Q4 SURGERY Pub Date : 2024-07-15 DOI: 10.52198/24.STI.44.OS1753
Sean B Sequeira, Matthew F Myntti, Michael A Mont

Periprosthetic joint infections (PJI) are devastating complications following total hip arthroplasty (THA) and are the most common reason for revision following primary arthroplasty. Although several devices, techniques, and procedures have been developed to combat this serious complication, there is little consensus as to how to prevent the development of PJI at the time of index arthroplasty. This article reviews the concept and implementation of a novel antimicrobial agent to substantially reduce the incidence of PJI. The regular implementation of this infection prophylaxis should be successful in drastically reducing the rate of PJI following primary THA.

假体周围关节感染(PJI)是全髋关节置换术(THA)后极具破坏性的并发症,也是初次关节置换术后最常见的翻修原因。尽管目前已开发出多种设备、技术和程序来应对这一严重并发症,但对于如何在初次关节置换术时预防 PJI 的发生仍缺乏共识。本文回顾了一种新型抗菌剂的概念和实施情况,该抗菌剂可大大降低 PJI 的发生率。定期实施这种感染预防措施应能成功大幅降低初次 THA 术后的 PJI 发生率。
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引用次数: 0
The Batalha Clitoropexy: Shortening an Elongated Clitoris - A Minimally Invasive Technique. Batalha 阴蒂整形术:缩短过长的阴蒂--一种微创技术。
IF 0.8 Q4 SURGERY Pub Date : 2024-07-15 DOI: 10.52198/24.STI.44.GY1766
John R Miklos, Robert D Moore, Cristina Sá Oliveira Maron, Ana Cristina Batalha

Background: Female cosmetic genital surgery is becoming increasingly sought after by women who are concerned with the appearance of their vulva. Labiaplasty for the labia minora is undoubtedly the most commonly performed female cosmetic genital surgery. However, an increasing number of patients seen in our clinics in both Brazil and the United States are presenting with clitoral hypertrophy, specifically clitoral elongation. The elongated clitoris will usually protrude beyond the labia minora and majora and from the patient's perspective will give a less feminine appearance as they will often describe the protruding clitoris as feeling like they have a small penis. The surgical technique described here, Batalha Clitoropexy, is a minimally invasive surgical technique for clitoral length-reduction that does not require amputation or debulking. This technique is presented in the form of the detailed sequential steps needed to achieve satisfactory results. Photos taken before and after the procedure in a representative case show that the clitoral length has been shortened from 5.0 cm to 1.5 cm without the need of an invasive amputation or debulking clitoroplasty. Many patients with clitoromegaly or an elongated protruding clitoris do not need to undergo an invasive clitoroplasty. Specifically, patients with clitoral elongation or clitoral ptosis can be surgically treated with a less-invasive clitoropexy surgical procedure which can restore normal anatomic position to treat a protruding clitoris.

背景:关注外阴外观的女性越来越多地寻求女性生殖器美容手术。小阴唇整形术无疑是最常见的女性生殖器整形手术。然而,在我们巴西和美国的诊所中,越来越多的患者出现阴蒂肥大,特别是阴蒂变长。拉长的阴蒂通常会突出于小阴唇和大阴唇之外,从患者的角度来看,会给人一种不那么女性化的感觉,因为她们通常会形容突出的阴蒂感觉就像有一个小阴茎。这里介绍的手术技术--Batalha 阴蒂整形术是一种微创手术技术,用于缩短阴蒂长度,无需截除或剥离阴蒂。该技术以达到满意效果所需的详细顺序步骤的形式呈现。一个具有代表性的病例在手术前后的照片显示,阴蒂长度已从 5.0 厘米缩短到 1.5 厘米,而无需进行侵入性截肢或去势阴蒂整形术。许多阴蒂肥大或阴蒂突出的患者并不需要进行侵入性阴蒂整形手术。具体来说,阴蒂过长或阴蒂下垂的患者可以通过创伤较小的阴蒂整形手术进行治疗,这种手术可以恢复正常的解剖位置,治疗阴蒂突出。
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引用次数: 0
The New Era of Three-Dimensional Annuloplasty Devices for Mitral Valve Repair: Rationale and First Experiences. 用于二尖瓣修复的三维瓣环成形设备的新时代:基本原理与初步经验。
IF 0.8 Q4 SURGERY Pub Date : 2024-07-15 DOI: 10.52198/24.STI.44.CV1795
Mario Torre, Luca Weltert, Raffaele Scaffa, Andrea Salica, Giulio Folino, Alessandro Ricci, Salvatore D'Aleo, Lorenzo Guerrieri Wolf, Francesco Irace, Ilaria Chirichilli, Samuel Fusca, Alessandro Bellisario, Alberto Bonadies, Marianna Primiterra, Ruggero De Paulis

Annuloplasty should always accompany mitral valve repair in order to achieve proper annular remodeling and stabilization. Numerous types of annuloplasty rings-that differ from rigid to semi-rigid and flexible devices, from complete to partial, and from flat to saddle-shaped rings-are clinically available. A deeper understanding of mitral valve function, in conjunction with several recent studies, suggest it is advisable to prefer annuloplasty rings that mimic the physiological mitral annulus shape and three-dimensional (3D) dynamic changes in order to reduce haemodynamic stress on valve components and optimize leaflet coaptation, perhaps improving valve repair durability too. This paper aims to focus on 3D annuloplasty rings, with dynamic features: MEMO 3D™ and MEMO 4D™ (Sorin Medical, New York, New York), as well as Physio Flex (Edwards Lifesciences, Irvine, California).

二尖瓣瓣环成形术应始终伴随二尖瓣修复术,以实现适当的瓣环重塑和稳定。临床上有多种类型的瓣环成形术--从硬性到半硬性和柔性装置,从完全成形到部分成形,从扁平环到鞍形环,不一而足。对二尖瓣功能的深入了解以及最近的一些研究表明,最好选择能模拟二尖瓣瓣环生理形状和三维(3D)动态变化的瓣环成形术,以减少瓣膜组件上的血流动力学应力,优化瓣叶的附着,或许还能提高瓣膜修复的耐久性。本文旨在重点介绍具有动态特征的三维瓣环成形术:MEMO 3D™ 和 MEMO 4D™(Sorin Medical,纽约州纽约市)以及 Physio Flex(Edwards Lifesciences,加利福尼亚州欧文市)。
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引用次数: 0
A Case Report of Neoadjuvant Gemcitabine Plus Cisplatin for Locally Advanced Unresectable Ampulla of Vater Carcinoma. 新辅助吉西他滨加顺铂治疗局部晚期不可切除的输卵管癌病例报告
IF 0.8 Q4 SURGERY Pub Date : 2024-07-15 DOI: 10.52198/24.STI.44.GS1768
Ryosuke Tsunemitsu, Motoyasu Tabuchi, Shinya Sakamoto, Rika Yoshimatsu, Mototsune Kakizaki, Manabu Matsumoto, Jun Iwata, Yasuhiro Shimada, Takehiro Okabayashi

Introduction: Ampulla of Vater carcinoma (AVC) with para-aortic node (PAN) metastasis is considered unresectable and is equivalent to distant metastasis, contributing to poor outcomes.

Case presentation: A 60-year-old man was referred to our hospital and was diagnosed with an unresectable ampulla of Vater carcinoma that had metastasized to the para-aortic nodes. The patient received a systemic chemotherapy regimen comprising a combination of gemcitabine and cisplatin. Following five cycles of treatment, imaging studies revealed a significant reduction in the primary tumor and para-aortic node metastasis, rendering detection difficult. Pancreatoduodenectomy with para-aortic node dissection was performed as a radical surgery. Upon pathological examination, no residual tumors were identified in the resected specimen, indicating that the systemic chemotherapy achieved a complete pathological response. The postoperative course of the patient was uneventful, and he was discharged on the 25th postoperative day. The patient was followed up as an outpatient and remained stable without any recurrence for two months after surgery.

Conclusion: Neoadjuvant chemotherapy with gemcitabine and cisplatin was useful for downstaging the ampulla in patients with Vater carcinoma. This finding may help physicians manage patients with similar presentations.

导言:主动脉旁结节(PAN)转移的瓦特氏鞍癌(AVC)被认为是不可切除的,等同于远处转移,导致治疗效果不佳:一名 60 岁的男性转诊至我院,被诊断为不可切除的 Vater ampulla 癌,并已转移至主动脉旁结节。患者接受了吉西他滨和顺铂联合的全身化疗方案。经过五个周期的治疗后,影像学检查显示原发肿瘤和主动脉旁结节转移灶明显缩小,因此难以发现。作为根治性手术,该患者接受了胰十二指肠切除术和主动脉旁结节切除术。经病理检查,切除标本中未发现残余肿瘤,表明全身化疗取得了完全病理反应。患者术后恢复顺利,于术后第 25 天出院。术后两个月,患者病情稳定,没有复发:结论:吉西他滨和顺铂的新辅助化疗有助于对Vater癌患者的安瓿进行分期。这一发现可能有助于医生管理具有类似表现的患者。
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引用次数: 0
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Surgical technology international
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