THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019最新文献
Dengue Fever (DF) in Indonesia has been a major health problem for the last 47 years, which keeps on rising until today. Quercitrin as one of the natural compounds, flavonol group and has been used in several types of research for their properties of anti-inflammation, anti-bacterial, anti-viral, and anti-fungi. The aim of this study was to explore the potency of quercitrin as an antiviral drug to dengue virus (DENV) in vitro and in silico. We used Focus assay, MTT assay, and docking analysis to determine IC50, CC50 and binding energy, respectively. The IC50, CC50 and Selectivity Index (SI) of quercitrin was 1.1 µg/ml, 38.8 µg/ml and 38 respectively. In silico study showed the binding energy between quercitrin and NS5 protein was −7,54 kkal/mol. The results obtained that Quercutrin as a good candidate for an antiviral drug to DENV in the future.Dengue Fever (DF) in Indonesia has been a major health problem for the last 47 years, which keeps on rising until today. Quercitrin as one of the natural compounds, flavonol group and has been used in several types of research for their properties of anti-inflammation, anti-bacterial, anti-viral, and anti-fungi. The aim of this study was to explore the potency of quercitrin as an antiviral drug to dengue virus (DENV) in vitro and in silico. We used Focus assay, MTT assay, and docking analysis to determine IC50, CC50 and binding energy, respectively. The IC50, CC50 and Selectivity Index (SI) of quercitrin was 1.1 µg/ml, 38.8 µg/ml and 38 respectively. In silico study showed the binding energy between quercitrin and NS5 protein was −7,54 kkal/mol. The results obtained that Quercutrin as a good candidate for an antiviral drug to DENV in the future.
{"title":"In vitro and in silico study to evaluate the effectiveness of quercitrin as antiviral drug to dengue virus","authors":"B. Dewi, E. Ratningpoeti, H. Desti, M. Angelina","doi":"10.1063/1.5139341","DOIUrl":"https://doi.org/10.1063/1.5139341","url":null,"abstract":"Dengue Fever (DF) in Indonesia has been a major health problem for the last 47 years, which keeps on rising until today. Quercitrin as one of the natural compounds, flavonol group and has been used in several types of research for their properties of anti-inflammation, anti-bacterial, anti-viral, and anti-fungi. The aim of this study was to explore the potency of quercitrin as an antiviral drug to dengue virus (DENV) in vitro and in silico. We used Focus assay, MTT assay, and docking analysis to determine IC50, CC50 and binding energy, respectively. The IC50, CC50 and Selectivity Index (SI) of quercitrin was 1.1 µg/ml, 38.8 µg/ml and 38 respectively. In silico study showed the binding energy between quercitrin and NS5 protein was −7,54 kkal/mol. The results obtained that Quercutrin as a good candidate for an antiviral drug to DENV in the future.Dengue Fever (DF) in Indonesia has been a major health problem for the last 47 years, which keeps on rising until today. Quercitrin as one of the natural compounds, flavonol group and has been used in several types of research for their properties of anti-inflammation, anti-bacterial, anti-viral, and anti-fungi. The aim of this study was to explore the potency of quercitrin as an antiviral drug to dengue virus (DENV) in vitro and in silico. We used Focus assay, MTT assay, and docking analysis to determine IC50, CC50 and binding energy, respectively. The IC50, CC50 and Selectivity Index (SI) of quercitrin was 1.1 µg/ml, 38.8 µg/ml and 38 respectively. In silico study showed the binding energy between quercitrin and NS5 protein was −7,54 kkal/mol. The results obtained that Quercutrin as a good candidate for an antiviral drug to DENV in the future.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88588418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Boiler is an important part of the Steam Power Plant. One of the combustion systems in the boiler is using the balance draft method, where combustion air conditions in the furnace supplied by Force Draft Fan (FDF), and residual combustion air (exhaust gas) are sucked with Induced Draft Fan (IDF) by maintaining the -30 Pa pressure furnace accordingly manufacturer’s standard. Furnace has not been able to achieve ideal conditions, because the performance of Induce Draft Fan (IDF) has less optimal suction power. This is allegedly from the opening of the Inlet Guide Vane which is not yet optimal. The test model in the form of Induce Draft Fan is simulated using CFD modeling software. The dimensions of the inlet guide vane, rotor, and static blade are carried out by 3D scanning. While for the casing model uses the manufacturer’s reference image. The results of this study are expected to improve IDF performance by determining the variation of the damper opening (IGV opening angle) optimally. From CFD simulation, pressure suction becomes more vacuum by opening the IGV from −10°, 0°, 10°, 40°, The value of the IDF pressure suction is −100 = −2494.7 Pa, 0° = −3129.5 Pa, 10° = −3398.2 Pa, 40° = −4425.2 Pa. Based on CFD simulations, the optimal damper opening is at 40°. At 41° opening of Inlet Guide Vane, the IDF suction ability decreases, This is indicated by the suction ability at −4249.4 Pa. Considering the process of setting the Inlet Guide Vane opening angle on the Induce Draft Fan requires a shutdown unit and production opportunities will disappear and the costs are relatively large, the performance optimization process is carried out using simulation.Boiler is an important part of the Steam Power Plant. One of the combustion systems in the boiler is using the balance draft method, where combustion air conditions in the furnace supplied by Force Draft Fan (FDF), and residual combustion air (exhaust gas) are sucked with Induced Draft Fan (IDF) by maintaining the -30 Pa pressure furnace accordingly manufacturer’s standard. Furnace has not been able to achieve ideal conditions, because the performance of Induce Draft Fan (IDF) has less optimal suction power. This is allegedly from the opening of the Inlet Guide Vane which is not yet optimal. The test model in the form of Induce Draft Fan is simulated using CFD modeling software. The dimensions of the inlet guide vane, rotor, and static blade are carried out by 3D scanning. While for the casing model uses the manufacturer’s reference image. The results of this study are expected to improve IDF performance by determining the variation of the damper opening (IGV opening angle) optimally. From CFD simulation,...
{"title":"Numerical study of optimization performance induced draft fan through openings setting the inlet guide vane","authors":"Yanuar Rulyanto, H. Mirmanto","doi":"10.1063/1.5138289","DOIUrl":"https://doi.org/10.1063/1.5138289","url":null,"abstract":"Boiler is an important part of the Steam Power Plant. One of the combustion systems in the boiler is using the balance draft method, where combustion air conditions in the furnace supplied by Force Draft Fan (FDF), and residual combustion air (exhaust gas) are sucked with Induced Draft Fan (IDF) by maintaining the -30 Pa pressure furnace accordingly manufacturer’s standard. Furnace has not been able to achieve ideal conditions, because the performance of Induce Draft Fan (IDF) has less optimal suction power. This is allegedly from the opening of the Inlet Guide Vane which is not yet optimal. The test model in the form of Induce Draft Fan is simulated using CFD modeling software. The dimensions of the inlet guide vane, rotor, and static blade are carried out by 3D scanning. While for the casing model uses the manufacturer’s reference image. The results of this study are expected to improve IDF performance by determining the variation of the damper opening (IGV opening angle) optimally. From CFD simulation, pressure suction becomes more vacuum by opening the IGV from −10°, 0°, 10°, 40°, The value of the IDF pressure suction is −100 = −2494.7 Pa, 0° = −3129.5 Pa, 10° = −3398.2 Pa, 40° = −4425.2 Pa. Based on CFD simulations, the optimal damper opening is at 40°. At 41° opening of Inlet Guide Vane, the IDF suction ability decreases, This is indicated by the suction ability at −4249.4 Pa. Considering the process of setting the Inlet Guide Vane opening angle on the Induce Draft Fan requires a shutdown unit and production opportunities will disappear and the costs are relatively large, the performance optimization process is carried out using simulation.Boiler is an important part of the Steam Power Plant. One of the combustion systems in the boiler is using the balance draft method, where combustion air conditions in the furnace supplied by Force Draft Fan (FDF), and residual combustion air (exhaust gas) are sucked with Induced Draft Fan (IDF) by maintaining the -30 Pa pressure furnace accordingly manufacturer’s standard. Furnace has not been able to achieve ideal conditions, because the performance of Induce Draft Fan (IDF) has less optimal suction power. This is allegedly from the opening of the Inlet Guide Vane which is not yet optimal. The test model in the form of Induce Draft Fan is simulated using CFD modeling software. The dimensions of the inlet guide vane, rotor, and static blade are carried out by 3D scanning. While for the casing model uses the manufacturer’s reference image. The results of this study are expected to improve IDF performance by determining the variation of the damper opening (IGV opening angle) optimally. From CFD simulation,...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"33 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89916890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Nurhayati, W. Mubarok, Rafianto Dwi Cahyo, Kamila Alawiyah
Recent advances in tissue engineering application for medical intervention has created a need for three-dimensional (3D) cellular microenvironment in the form of cellular microencapsulation. Cellular microencapsulation can be used in several applications such as in vitro drug screening as well as cellular transplantation. It is important to note, however, that despite all the benefit from the cells, the capsule itself also has a major role. Significant impact and even clinical risks can present if the capsule is not biocompatible or even toxic. Hence, careful consideration on the materials and more importantly the fabrication process of the capsule is needed. In this work, we presented a method for cellular encapsulation using oil immersion technique. Briefly, suspension of K562 cells and collagen was injected into the mineral oil on a cell strainer. Microcapsule then washed with PBS and immersed with culture medium. Photomicrograph analysis was performed to evaluate the shape as well as to measure the volume of the microcapsule. Immunohistochemistry staining with Propidium Iodide (PI) was used to confirm K562 entrapment within the microcapsule. Cellular microencapsulation using oil immersion technique resulted in a rounded sphere. The increased volume of cells-hydrogel suspension resulted in bigger diameter and volume of the capsule. Due to the nature of the immersion process, a layer of oil could be found outside the capsule. The volume of the oil on the border of the capsule also increased with higher hydrogel-cells suspension. PI-stained K562 cells were found within the microcapsule, confirming that K562 cells were indeed entrapped within the microcapsule. In conclusion, oil immersion technique provides a quick, easy, and feasible method to produce cellular microencapsulation
{"title":"Oil immersion technique for cellular microencapsulation","authors":"R. Nurhayati, W. Mubarok, Rafianto Dwi Cahyo, Kamila Alawiyah","doi":"10.1063/1.5139325","DOIUrl":"https://doi.org/10.1063/1.5139325","url":null,"abstract":"Recent advances in tissue engineering application for medical intervention has created a need for three-dimensional (3D) cellular microenvironment in the form of cellular microencapsulation. Cellular microencapsulation can be used in several applications such as in vitro drug screening as well as cellular transplantation. It is important to note, however, that despite all the benefit from the cells, the capsule itself also has a major role. Significant impact and even clinical risks can present if the capsule is not biocompatible or even toxic. Hence, careful consideration on the materials and more importantly the fabrication process of the capsule is needed. In this work, we presented a method for cellular encapsulation using oil immersion technique. Briefly, suspension of K562 cells and collagen was injected into the mineral oil on a cell strainer. Microcapsule then washed with PBS and immersed with culture medium. Photomicrograph analysis was performed to evaluate the shape as well as to measure the volume of the microcapsule. Immunohistochemistry staining with Propidium Iodide (PI) was used to confirm K562 entrapment within the microcapsule. Cellular microencapsulation using oil immersion technique resulted in a rounded sphere. The increased volume of cells-hydrogel suspension resulted in bigger diameter and volume of the capsule. Due to the nature of the immersion process, a layer of oil could be found outside the capsule. The volume of the oil on the border of the capsule also increased with higher hydrogel-cells suspension. PI-stained K562 cells were found within the microcapsule, confirming that K562 cells were indeed entrapped within the microcapsule. In conclusion, oil immersion technique provides a quick, easy, and feasible method to produce cellular microencapsulation","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78191809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Krisanti, Mutiara Primaster Wahyunisa, Nugrahirani Hijrianti, K. Mulia
The development of chitosan-alginate matrices loaded with Anredera cordifolia Steenis (Madeira-vine) leaf extract as an extended-release formulation is herewith described. Madeira-vine plants have been known used traditionally to treat various ailments such as anti-inflammation, hypertension, and skin diseases. The matrices were prepared using the ionotropic gelation methodwith tripolyphosphate as the cross-linking agent. Scanning electron microscope and Fourier transform infrared spectroscopy was used to investigate the surface morphology and the structure of the matrices, respectively. The effect of alginate addition was studied by determining the physical characteristics of the matrices, encapsulation efficiency, loading capacity, matrix yield, as well as the release profiles of the bioactive compounds in simulated gastrointestinal fluids. The bioactive compounds in the leaf extracts and matrices, quantified as total phenolics, were determined using UV-spectrophotometry. High-performance liquid chromatography was used to determine the amount of vitexin present in the leaf extracts. The encapsulation efficiency of the phenolic compounds was at least 90%, the highest loading capacity was 1.23%, and matrix yield was at least 83%. The in vitro release assays showed a reduced cumulative release of phenolic compounds in synthetic gastric fluid (35 to 12%), and, in three synthetic gastrointestinal fluids (71 to 50%) after 24 hours, due to the addition of alginate in the chitosan matrix. These results indicate the possibility of employing chitosan-alginate matrixto shift the release of phenolics of Anredera cordifolia extracts from the gastric area to the colon area.The development of chitosan-alginate matrices loaded with Anredera cordifolia Steenis (Madeira-vine) leaf extract as an extended-release formulation is herewith described. Madeira-vine plants have been known used traditionally to treat various ailments such as anti-inflammation, hypertension, and skin diseases. The matrices were prepared using the ionotropic gelation methodwith tripolyphosphate as the cross-linking agent. Scanning electron microscope and Fourier transform infrared spectroscopy was used to investigate the surface morphology and the structure of the matrices, respectively. The effect of alginate addition was studied by determining the physical characteristics of the matrices, encapsulation efficiency, loading capacity, matrix yield, as well as the release profiles of the bioactive compounds in simulated gastrointestinal fluids. The bioactive compounds in the leaf extracts and matrices, quantified as total phenolics, were determined using UV-spectrophotometry. High-performance liquid chromat...
{"title":"Chitosan-alginate matrices loaded with leaf extracts of Anredera cordifolia Steenis as a gastrointestinal extended-release formulation","authors":"E. Krisanti, Mutiara Primaster Wahyunisa, Nugrahirani Hijrianti, K. Mulia","doi":"10.1063/1.5139338","DOIUrl":"https://doi.org/10.1063/1.5139338","url":null,"abstract":"The development of chitosan-alginate matrices loaded with Anredera cordifolia Steenis (Madeira-vine) leaf extract as an extended-release formulation is herewith described. Madeira-vine plants have been known used traditionally to treat various ailments such as anti-inflammation, hypertension, and skin diseases. The matrices were prepared using the ionotropic gelation methodwith tripolyphosphate as the cross-linking agent. Scanning electron microscope and Fourier transform infrared spectroscopy was used to investigate the surface morphology and the structure of the matrices, respectively. The effect of alginate addition was studied by determining the physical characteristics of the matrices, encapsulation efficiency, loading capacity, matrix yield, as well as the release profiles of the bioactive compounds in simulated gastrointestinal fluids. The bioactive compounds in the leaf extracts and matrices, quantified as total phenolics, were determined using UV-spectrophotometry. High-performance liquid chromatography was used to determine the amount of vitexin present in the leaf extracts. The encapsulation efficiency of the phenolic compounds was at least 90%, the highest loading capacity was 1.23%, and matrix yield was at least 83%. The in vitro release assays showed a reduced cumulative release of phenolic compounds in synthetic gastric fluid (35 to 12%), and, in three synthetic gastrointestinal fluids (71 to 50%) after 24 hours, due to the addition of alginate in the chitosan matrix. These results indicate the possibility of employing chitosan-alginate matrixto shift the release of phenolics of Anredera cordifolia extracts from the gastric area to the colon area.The development of chitosan-alginate matrices loaded with Anredera cordifolia Steenis (Madeira-vine) leaf extract as an extended-release formulation is herewith described. Madeira-vine plants have been known used traditionally to treat various ailments such as anti-inflammation, hypertension, and skin diseases. The matrices were prepared using the ionotropic gelation methodwith tripolyphosphate as the cross-linking agent. Scanning electron microscope and Fourier transform infrared spectroscopy was used to investigate the surface morphology and the structure of the matrices, respectively. The effect of alginate addition was studied by determining the physical characteristics of the matrices, encapsulation efficiency, loading capacity, matrix yield, as well as the release profiles of the bioactive compounds in simulated gastrointestinal fluids. The bioactive compounds in the leaf extracts and matrices, quantified as total phenolics, were determined using UV-spectrophotometry. High-performance liquid chromat...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78479602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. A. P. Dwijayanto, Farisy Yogatama Sulistyo, M. Subekti
An issue concerning Experimental Power Reactor (Reaktor Daya Eksperimental/RDE), an HTGR-based experimental-scale nuclear power reactor proposed by National Nuclear Energy Agency (Badan Tenaga Nuklir Nasional/BATAN), is hot gas temperature deviation. To prevent safety-related problems caused by such deviation, RDE employs two levels of gas mixing for the heated coolant gas; the first level is bottom plenum and the second is hot gas chamber. Unlike the latter, bottom plenum is a simple empty column where the heated gas is mixed, but not homogeneous enough to be considered safe to be flown into the heat exchanger. To understand the mixing phenomena better, this paper will analyse the temperature homogenisation on the RDE bottom plenum, employing computational fluid dynamics-based method using FLUENT software. Simulation result shows that the coolant gas heterogeneity is reduced by 139.98°C, implying temperature homogeneity degree of 55.99%. This value provides insight on coolant gas parameter to perform more accurate calculation on the hot gas chamber. Temperature deviation pattern at the outlet channels is also discussed.An issue concerning Experimental Power Reactor (Reaktor Daya Eksperimental/RDE), an HTGR-based experimental-scale nuclear power reactor proposed by National Nuclear Energy Agency (Badan Tenaga Nuklir Nasional/BATAN), is hot gas temperature deviation. To prevent safety-related problems caused by such deviation, RDE employs two levels of gas mixing for the heated coolant gas; the first level is bottom plenum and the second is hot gas chamber. Unlike the latter, bottom plenum is a simple empty column where the heated gas is mixed, but not homogeneous enough to be considered safe to be flown into the heat exchanger. To understand the mixing phenomena better, this paper will analyse the temperature homogenisation on the RDE bottom plenum, employing computational fluid dynamics-based method using FLUENT software. Simulation result shows that the coolant gas heterogeneity is reduced by 139.98°C, implying temperature homogeneity degree of 55.99%. This value provides insight on coolant gas parameter to perform mor...
国家原子能机构(BATAN Tenaga Nuklir Nasional/BATAN)提出的基于高温高温堆的实验规模核动力反应堆(Reaktor Daya ekexperimental /RDE)存在的一个问题是热气体温度偏差。为了防止这种偏差引起的安全问题,RDE对加热的冷却剂气体采用两级气体混合;第一层是底部静压室,第二层是热毒气室。与后者不同,底部静压室是一个简单的空柱,被加热的气体在其中混合,但不是均匀的,被认为是安全的,可以飞进热交换器。为了更好地理解混合现象,本文将使用FLUENT软件,采用基于计算流体动力学的方法分析RDE底部静压室内的温度均匀化。模拟结果表明,冷却剂气体的非均匀性降低了139.98℃,温度均匀度达到55.99%。该值提供了对冷却剂气体参数的洞察力,以便对热气室进行更准确的计算。还讨论了出口通道的温度偏差规律。国家原子能机构(BATAN Tenaga Nuklir Nasional/BATAN)提出的基于高温高温堆的实验规模核动力反应堆(Reaktor Daya ekexperimental /RDE)存在的一个问题是热气体温度偏差。为了防止这种偏差引起的安全问题,RDE对加热的冷却剂气体采用两级气体混合;第一层是底部静压室,第二层是热毒气室。与后者不同,底部静压室是一个简单的空柱,被加热的气体在其中混合,但不是均匀的,被认为是安全的,可以飞进热交换器。为了更好地理解混合现象,本文将使用FLUENT软件,采用基于计算流体动力学的方法分析RDE底部静压室内的温度均匀化。模拟结果表明,冷却剂气体的非均匀性降低了139.98℃,温度均匀度达到55.99%。该值提供了对冷却剂气体参数的洞察力,以执行更多…
{"title":"CFD analysis on temperature homogenisation performance in experimental power reactor bottom plenum","authors":"R. A. P. Dwijayanto, Farisy Yogatama Sulistyo, M. Subekti","doi":"10.1063/1.5135530","DOIUrl":"https://doi.org/10.1063/1.5135530","url":null,"abstract":"An issue concerning Experimental Power Reactor (Reaktor Daya Eksperimental/RDE), an HTGR-based experimental-scale nuclear power reactor proposed by National Nuclear Energy Agency (Badan Tenaga Nuklir Nasional/BATAN), is hot gas temperature deviation. To prevent safety-related problems caused by such deviation, RDE employs two levels of gas mixing for the heated coolant gas; the first level is bottom plenum and the second is hot gas chamber. Unlike the latter, bottom plenum is a simple empty column where the heated gas is mixed, but not homogeneous enough to be considered safe to be flown into the heat exchanger. To understand the mixing phenomena better, this paper will analyse the temperature homogenisation on the RDE bottom plenum, employing computational fluid dynamics-based method using FLUENT software. Simulation result shows that the coolant gas heterogeneity is reduced by 139.98°C, implying temperature homogeneity degree of 55.99%. This value provides insight on coolant gas parameter to perform more accurate calculation on the hot gas chamber. Temperature deviation pattern at the outlet channels is also discussed.An issue concerning Experimental Power Reactor (Reaktor Daya Eksperimental/RDE), an HTGR-based experimental-scale nuclear power reactor proposed by National Nuclear Energy Agency (Badan Tenaga Nuklir Nasional/BATAN), is hot gas temperature deviation. To prevent safety-related problems caused by such deviation, RDE employs two levels of gas mixing for the heated coolant gas; the first level is bottom plenum and the second is hot gas chamber. Unlike the latter, bottom plenum is a simple empty column where the heated gas is mixed, but not homogeneous enough to be considered safe to be flown into the heat exchanger. To understand the mixing phenomena better, this paper will analyse the temperature homogenisation on the RDE bottom plenum, employing computational fluid dynamics-based method using FLUENT software. Simulation result shows that the coolant gas heterogeneity is reduced by 139.98°C, implying temperature homogeneity degree of 55.99%. This value provides insight on coolant gas parameter to perform mor...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73084971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Electrohydrodynamic drying (EHD) processes have been applied in many experiments. However, EHD rarely applied to drying medications, specifically medical powders. The EHD process reduces the water level of materials through a coronal wind by placing them between two electrodes that conduct a strong electric field. In this study, EHD is applied using needles with copper plates as the two electrodes. Within the same surface area, different numbers of needles (2×2, 3×3, and 4×4) are arranged to conduct the positive charge using the copper plate as the grounding system. By using various numbers of needles and modifying the gap between them and the material, the effect of the EHD process on the material, namely amoxicillin powder, is determined. Based on the experimental results, a 2×2 needle arrangement and 2-cm gap between the needles and the sample have the fastest drying speed as compared to other needle numbers and gaps.Electrohydrodynamic drying (EHD) processes have been applied in many experiments. However, EHD rarely applied to drying medications, specifically medical powders. The EHD process reduces the water level of materials through a coronal wind by placing them between two electrodes that conduct a strong electric field. In this study, EHD is applied using needles with copper plates as the two electrodes. Within the same surface area, different numbers of needles (2×2, 3×3, and 4×4) are arranged to conduct the positive charge using the copper plate as the grounding system. By using various numbers of needles and modifying the gap between them and the material, the effect of the EHD process on the material, namely amoxicillin powder, is determined. Based on the experimental results, a 2×2 needle arrangement and 2-cm gap between the needles and the sample have the fastest drying speed as compared to other needle numbers and gaps.
{"title":"Electrohydrodynamic drying process of the amoxicillin powder using a high direct current (DC) voltage","authors":"Nicholas, T. Abuzairi","doi":"10.1063/1.5139385","DOIUrl":"https://doi.org/10.1063/1.5139385","url":null,"abstract":"Electrohydrodynamic drying (EHD) processes have been applied in many experiments. However, EHD rarely applied to drying medications, specifically medical powders. The EHD process reduces the water level of materials through a coronal wind by placing them between two electrodes that conduct a strong electric field. In this study, EHD is applied using needles with copper plates as the two electrodes. Within the same surface area, different numbers of needles (2×2, 3×3, and 4×4) are arranged to conduct the positive charge using the copper plate as the grounding system. By using various numbers of needles and modifying the gap between them and the material, the effect of the EHD process on the material, namely amoxicillin powder, is determined. Based on the experimental results, a 2×2 needle arrangement and 2-cm gap between the needles and the sample have the fastest drying speed as compared to other needle numbers and gaps.Electrohydrodynamic drying (EHD) processes have been applied in many experiments. However, EHD rarely applied to drying medications, specifically medical powders. The EHD process reduces the water level of materials through a coronal wind by placing them between two electrodes that conduct a strong electric field. In this study, EHD is applied using needles with copper plates as the two electrodes. Within the same surface area, different numbers of needles (2×2, 3×3, and 4×4) are arranged to conduct the positive charge using the copper plate as the grounding system. By using various numbers of needles and modifying the gap between them and the material, the effect of the EHD process on the material, namely amoxicillin powder, is determined. Based on the experimental results, a 2×2 needle arrangement and 2-cm gap between the needles and the sample have the fastest drying speed as compared to other needle numbers and gaps.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76264974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Tjahjono, R. Kusumastuti, M. Juarsa, D. Haryanto, S. Widodo, A. S. Ekariansyah, Susyadi, M. Kusuma
In order to develop the design of Reactor Cavity Cooling System (RCCS) from High Temperature Reactors (HTRs), Center for Nuclear Reactor Technology and Safety (PTKRN) has built an RCCS experimental facility aimed for supporting the development of methods in designing a RCCS for a larger scale. This facility refers to the basic design of the RCCS of a 10 MWth Non-Commercial Power Reactor (RDNK) with a scale of 1/1 for height and 1/15 scale for width. With the availability of this experimental facility, characterization needs to evaluate whether the facility has functioned as planned. Especially for heating section, the initial design made called the Mod-1 is a model that is still open on all sides without insulation except on the back of the heating plate. The objective of this analysis is to determine the efficiency of this section. Analysis is carried out through numerical and analytical calculations by developing an calculation program based on Matlab. Two analysis conditions are evaluated such as normal condition and accident condition. The result shows that in normal condition, the efficiency of heating section is only 11.34%, and increase to 13,55% in accident conditions. It means that the heat released by the heating plate that is effectively received by cooling water through 5 riser pipes is very small. So, the heating section Mod-1 of RCCS Test Loop has very low efficiency and needs to be improved.
{"title":"Analysis of MOD-1 heating section efficiency in the RCCS test facility of high temperature reactors","authors":"H. Tjahjono, R. Kusumastuti, M. Juarsa, D. Haryanto, S. Widodo, A. S. Ekariansyah, Susyadi, M. Kusuma","doi":"10.1063/1.5135531","DOIUrl":"https://doi.org/10.1063/1.5135531","url":null,"abstract":"In order to develop the design of Reactor Cavity Cooling System (RCCS) from High Temperature Reactors (HTRs), Center for Nuclear Reactor Technology and Safety (PTKRN) has built an RCCS experimental facility aimed for supporting the development of methods in designing a RCCS for a larger scale. This facility refers to the basic design of the RCCS of a 10 MWth Non-Commercial Power Reactor (RDNK) with a scale of 1/1 for height and 1/15 scale for width. With the availability of this experimental facility, characterization needs to evaluate whether the facility has functioned as planned. Especially for heating section, the initial design made called the Mod-1 is a model that is still open on all sides without insulation except on the back of the heating plate. The objective of this analysis is to determine the efficiency of this section. Analysis is carried out through numerical and analytical calculations by developing an calculation program based on Matlab. Two analysis conditions are evaluated such as normal condition and accident condition. The result shows that in normal condition, the efficiency of heating section is only 11.34%, and increase to 13,55% in accident conditions. It means that the heat released by the heating plate that is effectively received by cooling water through 5 riser pipes is very small. So, the heating section Mod-1 of RCCS Test Loop has very low efficiency and needs to be improved.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"229 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74732178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Since ninety percent of the human population in the world are right-handed, many products and facilities are designed for right-handed people. In Indonesia, writing armchair with desktop fixed at the right side is a common product used at tertiary education level, which is uncomfortable for left-handed students because they have to tilt their bodies awkwardly to the right side. Inadequate facilities of left-sided writing armchair in educational institutions are caused by the unknown difference impact on the handwriting performance of left-handed students when using both types of writing armchairs. The purpose of this research is to find out the handwriting performance differences of left-handed students based on biomechanical ergonomic factors. Thirty left-handed university students, aged 18-23 years, participated in this research to conduct 30-minute handwriting experiments using left-sided and right-sided writing armchair. Four measurements parameter used were electromyography (to measure muscle activit...
{"title":"Biomechanical ergonomic evaluation of handwriting performance in left-handed students when using writing armchair","authors":"M. Rasyad, E. Muslim","doi":"10.1063/1.5139381","DOIUrl":"https://doi.org/10.1063/1.5139381","url":null,"abstract":"Since ninety percent of the human population in the world are right-handed, many products and facilities are designed for right-handed people. In Indonesia, writing armchair with desktop fixed at the right side is a common product used at tertiary education level, which is uncomfortable for left-handed students because they have to tilt their bodies awkwardly to the right side. Inadequate facilities of left-sided writing armchair in educational institutions are caused by the unknown difference impact on the handwriting performance of left-handed students when using both types of writing armchairs. The purpose of this research is to find out the handwriting performance differences of left-handed students based on biomechanical ergonomic factors. Thirty left-handed university students, aged 18-23 years, participated in this research to conduct 30-minute handwriting experiments using left-sided and right-sided writing armchair. Four measurements parameter used were electromyography (to measure muscle activit...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74452007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Harja, Tri Prakosa, S. Raharno, Y. Yuwana, I. Nurhadi, Rachmad Hartono, M. Zulfahmi, M.Yanti Pane, M. Yusuf
Industry 4.0 implementation faces crucial problem when applied in labor-intensive manufacturing industries, which are common industries in Indonesia. The problem is that it requires a well-connected and transparent data among production elements. The purpose of this study was to solve the aforementioned problem by building a cyber-physical workstation system as bridges between the production elements in real world with object models in virtual world. The system acts as a tools monitoring system for obtaining real-time information of actual tools utilization, especially for hand tools which are mostly used in labor-intensive manufacturing industries. The utilization of cyber-physical workstation system model may be the best method for determining the actual utilization of production tool with simple architecture, affordable and minimum negative impact. Workstation monitoring system transforms attendance data tools in the work area and start-finish operation time event into actual tool utilization information. The major contribution of this paper is that the implementation of industry 4.0 on labor-intensive manufacturing industry has become enabled by using cyber- physical workstation system. It was shown that the usage time of each tool on each production operation can be monitored. Furthermore, the estimation of the actual duration of each tool utilization can be calculated. The resulted data will be further utilized as primary data input for building smart tools model.Industry 4.0 implementation faces crucial problem when applied in labor-intensive manufacturing industries, which are common industries in Indonesia. The problem is that it requires a well-connected and transparent data among production elements. The purpose of this study was to solve the aforementioned problem by building a cyber-physical workstation system as bridges between the production elements in real world with object models in virtual world. The system acts as a tools monitoring system for obtaining real-time information of actual tools utilization, especially for hand tools which are mostly used in labor-intensive manufacturing industries. The utilization of cyber-physical workstation system model may be the best method for determining the actual utilization of production tool with simple architecture, affordable and minimum negative impact. Workstation monitoring system transforms attendance data tools in the work area and start-finish operation time event into actual tool utilization informati...
{"title":"Development of tools utilization monitoring system on labor-intensive manufacturing industries","authors":"H. Harja, Tri Prakosa, S. Raharno, Y. Yuwana, I. Nurhadi, Rachmad Hartono, M. Zulfahmi, M.Yanti Pane, M. Yusuf","doi":"10.1063/1.5138309","DOIUrl":"https://doi.org/10.1063/1.5138309","url":null,"abstract":"Industry 4.0 implementation faces crucial problem when applied in labor-intensive manufacturing industries, which are common industries in Indonesia. The problem is that it requires a well-connected and transparent data among production elements. The purpose of this study was to solve the aforementioned problem by building a cyber-physical workstation system as bridges between the production elements in real world with object models in virtual world. The system acts as a tools monitoring system for obtaining real-time information of actual tools utilization, especially for hand tools which are mostly used in labor-intensive manufacturing industries. The utilization of cyber-physical workstation system model may be the best method for determining the actual utilization of production tool with simple architecture, affordable and minimum negative impact. Workstation monitoring system transforms attendance data tools in the work area and start-finish operation time event into actual tool utilization information. The major contribution of this paper is that the implementation of industry 4.0 on labor-intensive manufacturing industry has become enabled by using cyber- physical workstation system. It was shown that the usage time of each tool on each production operation can be monitored. Furthermore, the estimation of the actual duration of each tool utilization can be calculated. The resulted data will be further utilized as primary data input for building smart tools model.Industry 4.0 implementation faces crucial problem when applied in labor-intensive manufacturing industries, which are common industries in Indonesia. The problem is that it requires a well-connected and transparent data among production elements. The purpose of this study was to solve the aforementioned problem by building a cyber-physical workstation system as bridges between the production elements in real world with object models in virtual world. The system acts as a tools monitoring system for obtaining real-time information of actual tools utilization, especially for hand tools which are mostly used in labor-intensive manufacturing industries. The utilization of cyber-physical workstation system model may be the best method for determining the actual utilization of production tool with simple architecture, affordable and minimum negative impact. Workstation monitoring system transforms attendance data tools in the work area and start-finish operation time event into actual tool utilization informati...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72554224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The use of coal with a lower quality than the coal design resulting in the un-optimation of the combustion process so that it will affect the unit performance or efficiency. Coal quality problems are not solely from the calorific value parameter but also on Hardgroove Grindability Index (HGI), this HGI value will affect to coal particle size (fineness) that goes into the furnace. Some of the impacts of the particle size bigger than standard size are the more unburn carbon, increasing the slagging fouling potential, and increasing the residence time of coal that will affect the furnace exit gas temperature is higher. Simulation with CFD is an effective and efficient solution to determine the effect of fineness on the boiler combustion characteristics. In modeling the gas phase combustion process, a mixed fraction approach is used with the probability density function (PDF) method. The input and boundary condition data are determined based on data collected when operating 600 MWe and for calculating coal particle size distribution using Rosin-Rammler law. The simulation is carried out by varying the three sizes of fineness, namely those that pass the 200 mesh sieve with 70%, 60% and 50%. The results obtained in the form of temperature and velocity distribution of combustion products to find out in any area in the boiler that potentially high level of erosion and where intensive particle deposition can occur, and to show the impact of particle size on un-burned carbon (UBC).The use of coal with a lower quality than the coal design resulting in the un-optimation of the combustion process so that it will affect the unit performance or efficiency. Coal quality problems are not solely from the calorific value parameter but also on Hardgroove Grindability Index (HGI), this HGI value will affect to coal particle size (fineness) that goes into the furnace. Some of the impacts of the particle size bigger than standard size are the more unburn carbon, increasing the slagging fouling potential, and increasing the residence time of coal that will affect the furnace exit gas temperature is higher. Simulation with CFD is an effective and efficient solution to determine the effect of fineness on the boiler combustion characteristics. In modeling the gas phase combustion process, a mixed fraction approach is used with the probability density function (PDF) method. The input and boundary condition data are determined based on data collected when operating 600 MWe and for calculating coal pa...
{"title":"Numerical simulation of coal particle size (fineness) effect to combustion characteristics of sub-critical pulverized coal boiler 600 MW capacity","authors":"H. Purnomo, B. Sudarmanta","doi":"10.1063/1.5138288","DOIUrl":"https://doi.org/10.1063/1.5138288","url":null,"abstract":"The use of coal with a lower quality than the coal design resulting in the un-optimation of the combustion process so that it will affect the unit performance or efficiency. Coal quality problems are not solely from the calorific value parameter but also on Hardgroove Grindability Index (HGI), this HGI value will affect to coal particle size (fineness) that goes into the furnace. Some of the impacts of the particle size bigger than standard size are the more unburn carbon, increasing the slagging fouling potential, and increasing the residence time of coal that will affect the furnace exit gas temperature is higher. Simulation with CFD is an effective and efficient solution to determine the effect of fineness on the boiler combustion characteristics. In modeling the gas phase combustion process, a mixed fraction approach is used with the probability density function (PDF) method. The input and boundary condition data are determined based on data collected when operating 600 MWe and for calculating coal particle size distribution using Rosin-Rammler law. The simulation is carried out by varying the three sizes of fineness, namely those that pass the 200 mesh sieve with 70%, 60% and 50%. The results obtained in the form of temperature and velocity distribution of combustion products to find out in any area in the boiler that potentially high level of erosion and where intensive particle deposition can occur, and to show the impact of particle size on un-burned carbon (UBC).The use of coal with a lower quality than the coal design resulting in the un-optimation of the combustion process so that it will affect the unit performance or efficiency. Coal quality problems are not solely from the calorific value parameter but also on Hardgroove Grindability Index (HGI), this HGI value will affect to coal particle size (fineness) that goes into the furnace. Some of the impacts of the particle size bigger than standard size are the more unburn carbon, increasing the slagging fouling potential, and increasing the residence time of coal that will affect the furnace exit gas temperature is higher. Simulation with CFD is an effective and efficient solution to determine the effect of fineness on the boiler combustion characteristics. In modeling the gas phase combustion process, a mixed fraction approach is used with the probability density function (PDF) method. The input and boundary condition data are determined based on data collected when operating 600 MWe and for calculating coal pa...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"296 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84872174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019