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In vitro and in silico study to evaluate the effectiveness of quercitrin as antiviral drug to dengue virus 体外和计算机研究评价槲皮素作为登革热病毒抗病毒药物的有效性
B. Dewi, E. Ratningpoeti, H. Desti, M. Angelina
Dengue Fever (DF) in Indonesia has been a major health problem for the last 47 years, which keeps on rising until today. Quercitrin as one of the natural compounds, flavonol group and has been used in several types of research for their properties of anti-inflammation, anti-bacterial, anti-viral, and anti-fungi. The aim of this study was to explore the potency of quercitrin as an antiviral drug to dengue virus (DENV) in vitro and in silico. We used Focus assay, MTT assay, and docking analysis to determine IC50, CC50 and binding energy, respectively. The IC50, CC50 and Selectivity Index (SI) of quercitrin was 1.1 µg/ml, 38.8 µg/ml and 38 respectively. In silico study showed the binding energy between quercitrin and NS5 protein was −7,54 kkal/mol. The results obtained that Quercutrin as a good candidate for an antiviral drug to DENV in the future.Dengue Fever (DF) in Indonesia has been a major health problem for the last 47 years, which keeps on rising until today. Quercitrin as one of the natural compounds, flavonol group and has been used in several types of research for their properties of anti-inflammation, anti-bacterial, anti-viral, and anti-fungi. The aim of this study was to explore the potency of quercitrin as an antiviral drug to dengue virus (DENV) in vitro and in silico. We used Focus assay, MTT assay, and docking analysis to determine IC50, CC50 and binding energy, respectively. The IC50, CC50 and Selectivity Index (SI) of quercitrin was 1.1 µg/ml, 38.8 µg/ml and 38 respectively. In silico study showed the binding energy between quercitrin and NS5 protein was −7,54 kkal/mol. The results obtained that Quercutrin as a good candidate for an antiviral drug to DENV in the future.
过去47年来,登革热在印度尼西亚一直是一个主要的健康问题,直到今天仍在不断上升。槲皮素作为黄酮醇类天然化合物之一,因其具有抗炎、抗菌、抗病毒、抗真菌等特性而被广泛应用于多种研究中。本研究的目的是探讨槲皮素作为登革热病毒(DENV)的抗病毒药物在体外和体内的效力。采用Focus法、MTT法和对接法分别测定IC50、CC50和结合能。槲皮苷的IC50、CC50和选择性指数分别为1.1µg/ml、38.8µg/ml和38。结果表明,槲皮素与NS5蛋白的结合能为−7.54 kkal/mol。结果表明,槲皮素是未来抗DENV的良好候选药物。过去47年来,登革热在印度尼西亚一直是一个主要的健康问题,直到今天仍在不断上升。槲皮素作为黄酮醇类天然化合物之一,因其具有抗炎、抗菌、抗病毒、抗真菌等特性而被广泛应用于多种研究中。本研究的目的是探讨槲皮素作为登革热病毒(DENV)的抗病毒药物在体外和体内的效力。采用Focus法、MTT法和对接法分别测定IC50、CC50和结合能。槲皮苷的IC50、CC50和选择性指数分别为1.1µg/ml、38.8µg/ml和38。结果表明,槲皮素与NS5蛋白的结合能为−7.54 kkal/mol。结果表明,槲皮素是未来抗DENV的良好候选药物。
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引用次数: 7
Numerical study of optimization performance induced draft fan through openings setting the inlet guide vane 通过设置进口导叶来优化引风机性能的数值研究
Yanuar Rulyanto, H. Mirmanto
Boiler is an important part of the Steam Power Plant. One of the combustion systems in the boiler is using the balance draft method, where combustion air conditions in the furnace supplied by Force Draft Fan (FDF), and residual combustion air (exhaust gas) are sucked with Induced Draft Fan (IDF) by maintaining the -30 Pa pressure furnace accordingly manufacturer’s standard. Furnace has not been able to achieve ideal conditions, because the performance of Induce Draft Fan (IDF) has less optimal suction power. This is allegedly from the opening of the Inlet Guide Vane which is not yet optimal. The test model in the form of Induce Draft Fan is simulated using CFD modeling software. The dimensions of the inlet guide vane, rotor, and static blade are carried out by 3D scanning. While for the casing model uses the manufacturer’s reference image. The results of this study are expected to improve IDF performance by determining the variation of the damper opening (IGV opening angle) optimally. From CFD simulation, pressure suction becomes more vacuum by opening the IGV from −10°, 0°, 10°, 40°, The value of the IDF pressure suction is −100 = −2494.7 Pa, 0° = −3129.5 Pa, 10° = −3398.2 Pa, 40° = −4425.2 Pa. Based on CFD simulations, the optimal damper opening is at 40°. At 41° opening of Inlet Guide Vane, the IDF suction ability decreases, This is indicated by the suction ability at −4249.4 Pa. Considering the process of setting the Inlet Guide Vane opening angle on the Induce Draft Fan requires a shutdown unit and production opportunities will disappear and the costs are relatively large, the performance optimization process is carried out using simulation.Boiler is an important part of the Steam Power Plant. One of the combustion systems in the boiler is using the balance draft method, where combustion air conditions in the furnace supplied by Force Draft Fan (FDF), and residual combustion air (exhaust gas) are sucked with Induced Draft Fan (IDF) by maintaining the -30 Pa pressure furnace accordingly manufacturer’s standard. Furnace has not been able to achieve ideal conditions, because the performance of Induce Draft Fan (IDF) has less optimal suction power. This is allegedly from the opening of the Inlet Guide Vane which is not yet optimal. The test model in the form of Induce Draft Fan is simulated using CFD modeling software. The dimensions of the inlet guide vane, rotor, and static blade are carried out by 3D scanning. While for the casing model uses the manufacturer’s reference image. The results of this study are expected to improve IDF performance by determining the variation of the damper opening (IGV opening angle) optimally. From CFD simulation,...
锅炉是蒸汽发电厂的重要组成部分。锅炉的一种燃烧系统是采用平衡送风法,即炉膛内的燃烧空气由引风机(FDF)提供,剩余的燃烧空气(废气)由引风机(IDF)吸入,并保持炉膛压力为- 30pa。引风机(IDF)的性能没有达到最优吸力,导致加热炉一直未能达到理想状态。这是据称从入口导叶的开放,这还不是最佳的。采用CFD建模软件对引风机形式的试验模型进行了仿真。进气导叶、转子和静叶片的尺寸是通过三维扫描进行的。而对于套管模型则使用制造商的参考图像。本研究的结果有望通过确定最佳阻尼器开度(IGV开度角)的变化来改善IDF性能。从CFD模拟来看,在- 10°、0°、10°、40°打开IGV后,压力吸力变得更加真空,IDF压力吸力值分别为- 100 = - 2494.7 Pa、0°= - 3129.5 Pa、10°= - 3398.2 Pa、40°= - 4425.2 Pa。基于CFD仿真,最佳阻尼器开度为40°。在进口导叶开度为41°时,IDF的吸力下降,这可以通过- 4249.4 Pa的吸力来表示。考虑到引风机进口导叶开角设置过程需要停机机组,生产机会消失,成本较大,采用仿真方法进行性能优化过程。锅炉是蒸汽发电厂的重要组成部分。锅炉的一种燃烧系统是采用平衡送风法,即炉膛内的燃烧空气由引风机(FDF)提供,剩余的燃烧空气(废气)由引风机(IDF)吸入,并保持炉膛压力为- 30pa。引风机(IDF)的性能没有达到最优吸力,导致加热炉一直未能达到理想状态。这是据称从入口导叶的开放,这还不是最佳的。采用CFD建模软件对引风机形式的试验模型进行了仿真。进气导叶、转子和静叶片的尺寸是通过三维扫描进行的。而对于套管模型则使用制造商的参考图像。本研究的结果有望通过确定最佳阻尼器开度(IGV开度角)的变化来改善IDF性能。从CFD模拟中,…
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引用次数: 0
Oil immersion technique for cellular microencapsulation 细胞微胶囊化的油浸技术
R. Nurhayati, W. Mubarok, Rafianto Dwi Cahyo, Kamila Alawiyah
Recent advances in tissue engineering application for medical intervention has created a need for three-dimensional (3D) cellular microenvironment in the form of cellular microencapsulation. Cellular microencapsulation can be used in several applications such as in vitro drug screening as well as cellular transplantation. It is important to note, however, that despite all the benefit from the cells, the capsule itself also has a major role. Significant impact and even clinical risks can present if the capsule is not biocompatible or even toxic. Hence, careful consideration on the materials and more importantly the fabrication process of the capsule is needed. In this work, we presented a method for cellular encapsulation using oil immersion technique. Briefly, suspension of K562 cells and collagen was injected into the mineral oil on a cell strainer. Microcapsule then washed with PBS and immersed with culture medium. Photomicrograph analysis was performed to evaluate the shape as well as to measure the volume of the microcapsule. Immunohistochemistry staining with Propidium Iodide (PI) was used to confirm K562 entrapment within the microcapsule. Cellular microencapsulation using oil immersion technique resulted in a rounded sphere. The increased volume of cells-hydrogel suspension resulted in bigger diameter and volume of the capsule. Due to the nature of the immersion process, a layer of oil could be found outside the capsule. The volume of the oil on the border of the capsule also increased with higher hydrogel-cells suspension. PI-stained K562 cells were found within the microcapsule, confirming that K562 cells were indeed entrapped within the microcapsule. In conclusion, oil immersion technique provides a quick, easy, and feasible method to produce cellular microencapsulation
组织工程应用于医疗干预的最新进展创造了以细胞微胶囊形式的三维(3D)细胞微环境的需求。细胞微囊化可以用于多种应用,如体外药物筛选以及细胞移植。然而,值得注意的是,尽管这些细胞有很多好处,但胶囊本身也起着重要作用。如果胶囊不具有生物相容性甚至有毒,则会产生重大影响甚至临床风险。因此,需要仔细考虑材料,更重要的是胶囊的制造工艺。在本研究中,我们提出了一种利用油浸技术进行细胞包封的方法。简单地说,将K562细胞和胶原的悬浮液通过细胞过滤器注射到矿物油中。然后用PBS洗涤微胶囊,用培养基浸泡。显微分析进行了评估形状以及测量微胶囊的体积。免疫组织化学染色碘化丙啶(PI)证实K562包埋在微胶囊内。细胞微胶囊化采用油浸技术,形成一个圆形球体。细胞-水凝胶悬浮液体积增大,囊直径增大,囊体积增大。由于浸没过程的性质,可以在胶囊外面发现一层油。水凝胶细胞悬浮液浓度越高,胶囊边缘的油体积也越大。在微胶囊内发现pi染色的K562细胞,证实K562细胞确实包被在微胶囊内。总之,油浸技术是一种快速、简便、可行的制备细胞微胶囊的方法
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引用次数: 0
Chitosan-alginate matrices loaded with leaf extracts of Anredera cordifolia Steenis as a gastrointestinal extended-release formulation 壳聚糖-海藻酸盐基质负载堇青花叶提取物作为胃肠道缓释制剂
E. Krisanti, Mutiara Primaster Wahyunisa, Nugrahirani Hijrianti, K. Mulia
The development of chitosan-alginate matrices loaded with Anredera cordifolia Steenis (Madeira-vine) leaf extract as an extended-release formulation is herewith described. Madeira-vine plants have been known used traditionally to treat various ailments such as anti-inflammation, hypertension, and skin diseases. The matrices were prepared using the ionotropic gelation methodwith tripolyphosphate as the cross-linking agent. Scanning electron microscope and Fourier transform infrared spectroscopy was used to investigate the surface morphology and the structure of the matrices, respectively. The effect of alginate addition was studied by determining the physical characteristics of the matrices, encapsulation efficiency, loading capacity, matrix yield, as well as the release profiles of the bioactive compounds in simulated gastrointestinal fluids. The bioactive compounds in the leaf extracts and matrices, quantified as total phenolics, were determined using UV-spectrophotometry. High-performance liquid chromatography was used to determine the amount of vitexin present in the leaf extracts. The encapsulation efficiency of the phenolic compounds was at least 90%, the highest loading capacity was 1.23%, and matrix yield was at least 83%. The in vitro release assays showed a reduced cumulative release of phenolic compounds in synthetic gastric fluid (35 to 12%), and, in three synthetic gastrointestinal fluids (71 to 50%) after 24 hours, due to the addition of alginate in the chitosan matrix. These results indicate the possibility of employing chitosan-alginate matrixto shift the release of phenolics of Anredera cordifolia extracts from the gastric area to the colon area.The development of chitosan-alginate matrices loaded with Anredera cordifolia Steenis (Madeira-vine) leaf extract as an extended-release formulation is herewith described. Madeira-vine plants have been known used traditionally to treat various ailments such as anti-inflammation, hypertension, and skin diseases. The matrices were prepared using the ionotropic gelation methodwith tripolyphosphate as the cross-linking agent. Scanning electron microscope and Fourier transform infrared spectroscopy was used to investigate the surface morphology and the structure of the matrices, respectively. The effect of alginate addition was studied by determining the physical characteristics of the matrices, encapsulation efficiency, loading capacity, matrix yield, as well as the release profiles of the bioactive compounds in simulated gastrointestinal fluids. The bioactive compounds in the leaf extracts and matrices, quantified as total phenolics, were determined using UV-spectrophotometry. High-performance liquid chromat...
本文描述了壳聚糖-海藻酸盐基质的开发,壳聚糖-海藻酸盐基质装载了马德拉葡萄叶提取物作为缓释制剂。传统上,马德拉藤蔓植物被用来治疗各种疾病,如抗炎、高血压和皮肤病。以三聚磷酸酯为交联剂,采用离子化凝胶法制备基质。利用扫描电镜和傅里叶变换红外光谱分别对基体的表面形貌和结构进行了表征。通过测定基质的物理特性、包封效率、负载能力、基质产率以及生物活性化合物在模拟胃肠道液体中的释放曲线,研究了海藻酸盐的添加效果。用紫外分光光度法测定叶提取物和基质中总酚类物质的活性成分。采用高效液相色谱法测定其提取物中牡荆素的含量。酚类化合物包封率至少为90%,最高负载量为1.23%,基质收率至少为83%。体外释放试验显示,由于在壳聚糖基质中添加海藻酸盐,24小时后,合成胃液中酚类化合物的累积释放量(35%至12%)和三种合成胃肠液(71%至50%)减少。这些结果表明,壳聚糖海藻酸盐基质有可能将凤梨提取物中酚类物质的释放从胃区转移到结肠区。本文描述了壳聚糖-海藻酸盐基质的开发,壳聚糖-海藻酸盐基质装载了马德拉葡萄叶提取物作为缓释制剂。传统上,马德拉藤蔓植物被用来治疗各种疾病,如抗炎、高血压和皮肤病。以三聚磷酸酯为交联剂,采用离子化凝胶法制备基质。利用扫描电镜和傅里叶变换红外光谱分别对基体的表面形貌和结构进行了表征。通过测定基质的物理特性、包封效率、负载能力、基质产率以及生物活性化合物在模拟胃肠道液体中的释放曲线,研究了海藻酸盐的添加效果。用紫外分光光度法测定叶提取物和基质中总酚类物质的活性成分。高效液相色谱…
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引用次数: 4
CFD analysis on temperature homogenisation performance in experimental power reactor bottom plenum 实验动力堆底充气室温度均匀性的CFD分析
R. A. P. Dwijayanto, Farisy Yogatama Sulistyo, M. Subekti
An issue concerning Experimental Power Reactor (Reaktor Daya Eksperimental/RDE), an HTGR-based experimental-scale nuclear power reactor proposed by National Nuclear Energy Agency (Badan Tenaga Nuklir Nasional/BATAN), is hot gas temperature deviation. To prevent safety-related problems caused by such deviation, RDE employs two levels of gas mixing for the heated coolant gas; the first level is bottom plenum and the second is hot gas chamber. Unlike the latter, bottom plenum is a simple empty column where the heated gas is mixed, but not homogeneous enough to be considered safe to be flown into the heat exchanger. To understand the mixing phenomena better, this paper will analyse the temperature homogenisation on the RDE bottom plenum, employing computational fluid dynamics-based method using FLUENT software. Simulation result shows that the coolant gas heterogeneity is reduced by 139.98°C, implying temperature homogeneity degree of 55.99%. This value provides insight on coolant gas parameter to perform more accurate calculation on the hot gas chamber. Temperature deviation pattern at the outlet channels is also discussed.An issue concerning Experimental Power Reactor (Reaktor Daya Eksperimental/RDE), an HTGR-based experimental-scale nuclear power reactor proposed by National Nuclear Energy Agency (Badan Tenaga Nuklir Nasional/BATAN), is hot gas temperature deviation. To prevent safety-related problems caused by such deviation, RDE employs two levels of gas mixing for the heated coolant gas; the first level is bottom plenum and the second is hot gas chamber. Unlike the latter, bottom plenum is a simple empty column where the heated gas is mixed, but not homogeneous enough to be considered safe to be flown into the heat exchanger. To understand the mixing phenomena better, this paper will analyse the temperature homogenisation on the RDE bottom plenum, employing computational fluid dynamics-based method using FLUENT software. Simulation result shows that the coolant gas heterogeneity is reduced by 139.98°C, implying temperature homogeneity degree of 55.99%. This value provides insight on coolant gas parameter to perform mor...
国家原子能机构(BATAN Tenaga Nuklir Nasional/BATAN)提出的基于高温高温堆的实验规模核动力反应堆(Reaktor Daya ekexperimental /RDE)存在的一个问题是热气体温度偏差。为了防止这种偏差引起的安全问题,RDE对加热的冷却剂气体采用两级气体混合;第一层是底部静压室,第二层是热毒气室。与后者不同,底部静压室是一个简单的空柱,被加热的气体在其中混合,但不是均匀的,被认为是安全的,可以飞进热交换器。为了更好地理解混合现象,本文将使用FLUENT软件,采用基于计算流体动力学的方法分析RDE底部静压室内的温度均匀化。模拟结果表明,冷却剂气体的非均匀性降低了139.98℃,温度均匀度达到55.99%。该值提供了对冷却剂气体参数的洞察力,以便对热气室进行更准确的计算。还讨论了出口通道的温度偏差规律。国家原子能机构(BATAN Tenaga Nuklir Nasional/BATAN)提出的基于高温高温堆的实验规模核动力反应堆(Reaktor Daya ekexperimental /RDE)存在的一个问题是热气体温度偏差。为了防止这种偏差引起的安全问题,RDE对加热的冷却剂气体采用两级气体混合;第一层是底部静压室,第二层是热毒气室。与后者不同,底部静压室是一个简单的空柱,被加热的气体在其中混合,但不是均匀的,被认为是安全的,可以飞进热交换器。为了更好地理解混合现象,本文将使用FLUENT软件,采用基于计算流体动力学的方法分析RDE底部静压室内的温度均匀化。模拟结果表明,冷却剂气体的非均匀性降低了139.98℃,温度均匀度达到55.99%。该值提供了对冷却剂气体参数的洞察力,以执行更多…
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引用次数: 0
Electrohydrodynamic drying process of the amoxicillin powder using a high direct current (DC) voltage 利用直流高压对阿莫西林粉末进行电液干燥
Nicholas, T. Abuzairi
Electrohydrodynamic drying (EHD) processes have been applied in many experiments. However, EHD rarely applied to drying medications, specifically medical powders. The EHD process reduces the water level of materials through a coronal wind by placing them between two electrodes that conduct a strong electric field. In this study, EHD is applied using needles with copper plates as the two electrodes. Within the same surface area, different numbers of needles (2×2, 3×3, and 4×4) are arranged to conduct the positive charge using the copper plate as the grounding system. By using various numbers of needles and modifying the gap between them and the material, the effect of the EHD process on the material, namely amoxicillin powder, is determined. Based on the experimental results, a 2×2 needle arrangement and 2-cm gap between the needles and the sample have the fastest drying speed as compared to other needle numbers and gaps.Electrohydrodynamic drying (EHD) processes have been applied in many experiments. However, EHD rarely applied to drying medications, specifically medical powders. The EHD process reduces the water level of materials through a coronal wind by placing them between two electrodes that conduct a strong electric field. In this study, EHD is applied using needles with copper plates as the two electrodes. Within the same surface area, different numbers of needles (2×2, 3×3, and 4×4) are arranged to conduct the positive charge using the copper plate as the grounding system. By using various numbers of needles and modifying the gap between them and the material, the effect of the EHD process on the material, namely amoxicillin powder, is determined. Based on the experimental results, a 2×2 needle arrangement and 2-cm gap between the needles and the sample have the fastest drying speed as compared to other needle numbers and gaps.
电液动力干燥(EHD)工艺已在许多实验中得到应用。然而,EHD很少应用于干燥药物,特别是药用粉末。EHD过程通过日冕风将材料放置在两个传导强电场的电极之间,从而降低材料的水位。在本研究中,EHD采用带铜板的针作为两个电极。在同一表面积内,采用不同数量的针(2×2、3×3、4×4)以铜板为接地系统引导正电荷。通过使用不同数量的针,并修改针与物料之间的间隙,确定EHD工艺对物料即阿莫西林粉末的影响。实验结果表明,与其他针数和针距相比,2×2针距和针距2 cm的针距与样品的干燥速度最快。电液动力干燥(EHD)工艺已在许多实验中得到应用。然而,EHD很少应用于干燥药物,特别是药用粉末。EHD过程通过日冕风将材料放置在两个传导强电场的电极之间,从而降低材料的水位。在本研究中,EHD采用带铜板的针作为两个电极。在同一表面积内,采用不同数量的针(2×2、3×3、4×4)以铜板为接地系统引导正电荷。通过使用不同数量的针,并修改针与物料之间的间隙,确定EHD工艺对物料即阿莫西林粉末的影响。实验结果表明,与其他针数和针距相比,2×2针距和针距2 cm的针距与样品的干燥速度最快。
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引用次数: 2
Analysis of MOD-1 heating section efficiency in the RCCS test facility of high temperature reactors 高温反应堆RCCS试验装置MOD-1加热段效率分析
H. Tjahjono, R. Kusumastuti, M. Juarsa, D. Haryanto, S. Widodo, A. S. Ekariansyah, Susyadi, M. Kusuma
In order to develop the design of Reactor Cavity Cooling System (RCCS) from High Temperature Reactors (HTRs), Center for Nuclear Reactor Technology and Safety (PTKRN) has built an RCCS experimental facility aimed for supporting the development of methods in designing a RCCS for a larger scale. This facility refers to the basic design of the RCCS of a 10 MWth Non-Commercial Power Reactor (RDNK) with a scale of 1/1 for height and 1/15 scale for width. With the availability of this experimental facility, characterization needs to evaluate whether the facility has functioned as planned. Especially for heating section, the initial design made called the Mod-1 is a model that is still open on all sides without insulation except on the back of the heating plate. The objective of this analysis is to determine the efficiency of this section. Analysis is carried out through numerical and analytical calculations by developing an calculation program based on Matlab. Two analysis conditions are evaluated such as normal condition and accident condition. The result shows that in normal condition, the efficiency of heating section is only 11.34%, and increase to 13,55% in accident conditions. It means that the heat released by the heating plate that is effectively received by cooling water through 5 riser pipes is very small. So, the heating section Mod-1 of RCCS Test Loop has very low efficiency and needs to be improved.
为了开发高温反应堆的堆腔冷却系统(RCCS)的设计,核反应堆技术与安全中心(PTKRN)建立了一个RCCS实验设施,旨在支持开发更大规模的RCCS设计方法。该设施参照10兆瓦非商业动力堆(RDNK) RCCS的基本设计,高度比例为1/1,宽度比例为1/15。随着该实验设施的可用性,表征需要评估该设施是否按计划发挥作用。特别是在加热部分,最初的设计称为Mod-1,是除了加热板背面外,所有方面都是开放的,没有绝缘的模型。此分析的目的是确定该部分的效率。通过基于Matlab开发的计算程序,通过数值计算和解析计算进行分析。对正常工况和事故工况两种分析条件进行了评价。结果表明,在正常工况下,加热段效率仅为11.34%,在事故工况下可提高到13.55%。也就是说,冷却水通过5根立管有效接收的加热板放出的热量非常小。因此,RCCS测试回路的加热段mod1效率很低,需要改进。
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引用次数: 0
Biomechanical ergonomic evaluation of handwriting performance in left-handed students when using writing armchair 左手学生使用写字椅时书写表现之生物力学与工效学评价
M. Rasyad, E. Muslim
Since ninety percent of the human population in the world are right-handed, many products and facilities are designed for right-handed people. In Indonesia, writing armchair with desktop fixed at the right side is a common product used at tertiary education level, which is uncomfortable for left-handed students because they have to tilt their bodies awkwardly to the right side. Inadequate facilities of left-sided writing armchair in educational institutions are caused by the unknown difference impact on the handwriting performance of left-handed students when using both types of writing armchairs. The purpose of this research is to find out the handwriting performance differences of left-handed students based on biomechanical ergonomic factors. Thirty left-handed university students, aged 18-23 years, participated in this research to conduct 30-minute handwriting experiments using left-sided and right-sided writing armchair. Four measurements parameter used were electromyography (to measure muscle activit...
由于世界上90%的人都是右撇子,许多产品和设施都是为右撇子设计的。在印度尼西亚,桌面固定在右侧的写字扶手椅是高等教育中常见的产品,对于左撇子学生来说,这让他们很不舒服,因为他们必须笨拙地向右侧倾斜身体。教育机构中左侧书写扶手椅的设施不足是由于使用两种类型的书写扶手椅对左撇子学生书写表现的影响存在未知的差异。本研究的目的是在生物力学与人体工程学因素的基础上,找出左撇子学生书写表现的差异。本研究选取30名年龄在18-23岁的左撇子大学生,分别使用左右两种书写扶手椅进行了30分钟的书写实验。使用的四个测量参数是肌电图(测量肌肉活动…
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引用次数: 0
Development of tools utilization monitoring system on labor-intensive manufacturing industries 劳动密集型制造业工具利用监测系统的开发
H. Harja, Tri Prakosa, S. Raharno, Y. Yuwana, I. Nurhadi, Rachmad Hartono, M. Zulfahmi, M.Yanti Pane, M. Yusuf
Industry 4.0 implementation faces crucial problem when applied in labor-intensive manufacturing industries, which are common industries in Indonesia. The problem is that it requires a well-connected and transparent data among production elements. The purpose of this study was to solve the aforementioned problem by building a cyber-physical workstation system as bridges between the production elements in real world with object models in virtual world. The system acts as a tools monitoring system for obtaining real-time information of actual tools utilization, especially for hand tools which are mostly used in labor-intensive manufacturing industries. The utilization of cyber-physical workstation system model may be the best method for determining the actual utilization of production tool with simple architecture, affordable and minimum negative impact. Workstation monitoring system transforms attendance data tools in the work area and start-finish operation time event into actual tool utilization information. The major contribution of this paper is that the implementation of industry 4.0 on labor-intensive manufacturing industry has become enabled by using cyber- physical workstation system. It was shown that the usage time of each tool on each production operation can be monitored. Furthermore, the estimation of the actual duration of each tool utilization can be calculated. The resulted data will be further utilized as primary data input for building smart tools model.Industry 4.0 implementation faces crucial problem when applied in labor-intensive manufacturing industries, which are common industries in Indonesia. The problem is that it requires a well-connected and transparent data among production elements. The purpose of this study was to solve the aforementioned problem by building a cyber-physical workstation system as bridges between the production elements in real world with object models in virtual world. The system acts as a tools monitoring system for obtaining real-time information of actual tools utilization, especially for hand tools which are mostly used in labor-intensive manufacturing industries. The utilization of cyber-physical workstation system model may be the best method for determining the actual utilization of production tool with simple architecture, affordable and minimum negative impact. Workstation monitoring system transforms attendance data tools in the work area and start-finish operation time event into actual tool utilization informati...
工业4.0的实施在印尼常见的劳动密集型制造业中面临着关键问题。问题是,它需要在生产元素之间建立良好的连接和透明的数据。本研究旨在透过建立资讯物理工作站系统,将真实世界的生产要素与虚拟世界的物件模型连结起来,以解决上述问题。该系统可作为工具监控系统,获取工具实际使用情况的实时信息,尤其适用于劳动密集型制造业中使用较多的手工工具。利用信息物理工作站系统模型可能是确定生产工具实际利用率的最佳方法,其结构简单,价格合理,负面影响最小。工作站监控系统将工作区域内工具的考勤数据和起止作业时间事件转换为实际的工具使用信息。本文的主要贡献是通过使用网络物理工作站系统使工业4.0在劳动密集型制造业的实施成为可能。结果表明,每种刀具在每次生产操作中的使用时间都是可以监控的。此外,可以计算出每个工具使用的实际持续时间的估计。结果数据将进一步用作构建智能工具模型的主要数据输入。工业4.0的实施在印尼常见的劳动密集型制造业中面临着关键问题。问题是,它需要在生产元素之间建立良好的连接和透明的数据。本研究旨在透过建立资讯物理工作站系统,将真实世界的生产要素与虚拟世界的物件模型连结起来,以解决上述问题。该系统可作为工具监控系统,获取工具实际使用情况的实时信息,尤其适用于劳动密集型制造业中使用较多的手工工具。利用信息物理工作站系统模型可能是确定生产工具实际利用率的最佳方法,其结构简单,价格合理,负面影响最小。工作站监控系统将工作区域内工具的考勤数据和起止作业时间事件转换为实际的工具使用信息。
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引用次数: 3
Numerical simulation of coal particle size (fineness) effect to combustion characteristics of sub-critical pulverized coal boiler 600 MW capacity 煤粒度(细度)对600mw亚临界煤粉锅炉燃烧特性影响的数值模拟
H. Purnomo, B. Sudarmanta
The use of coal with a lower quality than the coal design resulting in the un-optimation of the combustion process so that it will affect the unit performance or efficiency. Coal quality problems are not solely from the calorific value parameter but also on Hardgroove Grindability Index (HGI), this HGI value will affect to coal particle size (fineness) that goes into the furnace. Some of the impacts of the particle size bigger than standard size are the more unburn carbon, increasing the slagging fouling potential, and increasing the residence time of coal that will affect the furnace exit gas temperature is higher. Simulation with CFD is an effective and efficient solution to determine the effect of fineness on the boiler combustion characteristics. In modeling the gas phase combustion process, a mixed fraction approach is used with the probability density function (PDF) method. The input and boundary condition data are determined based on data collected when operating 600 MWe and for calculating coal particle size distribution using Rosin-Rammler law. The simulation is carried out by varying the three sizes of fineness, namely those that pass the 200 mesh sieve with 70%, 60% and 50%. The results obtained in the form of temperature and velocity distribution of combustion products to find out in any area in the boiler that potentially high level of erosion and where intensive particle deposition can occur, and to show the impact of particle size on un-burned carbon (UBC).The use of coal with a lower quality than the coal design resulting in the un-optimation of the combustion process so that it will affect the unit performance or efficiency. Coal quality problems are not solely from the calorific value parameter but also on Hardgroove Grindability Index (HGI), this HGI value will affect to coal particle size (fineness) that goes into the furnace. Some of the impacts of the particle size bigger than standard size are the more unburn carbon, increasing the slagging fouling potential, and increasing the residence time of coal that will affect the furnace exit gas temperature is higher. Simulation with CFD is an effective and efficient solution to determine the effect of fineness on the boiler combustion characteristics. In modeling the gas phase combustion process, a mixed fraction approach is used with the probability density function (PDF) method. The input and boundary condition data are determined based on data collected when operating 600 MWe and for calculating coal pa...
使用比设计煤质量低的煤,导致燃烧过程不优化,从而影响机组性能或效率。煤质问题不仅仅来自于热值参数,还与硬槽可磨性指数有关,硬槽可磨性指数的大小直接影响进炉煤的粒度(细度)。粒径大于标准粒径的影响有:未燃碳多,结渣结垢势增大,煤停留时间延长,影响炉膛出口烟气温度升高。CFD模拟是确定细度对锅炉燃烧特性影响的有效方法。在气相燃烧过程建模中,采用了混合分数法和概率密度函数(PDF)方法。输入和边界条件数据是根据运行600mwe时收集的数据确定的,并利用松香-拉姆勒定律计算煤的粒度分布。通过改变200目筛分70%、60%和50%三种细度进行模拟。结果以燃烧产物的温度和速度分布的形式获得,以找出锅炉中任何可能发生高水平侵蚀和密集颗粒沉积的区域,并显示颗粒大小对未燃烧碳(UBC)的影响。使用比设计煤质量低的煤,导致燃烧过程不优化,从而影响机组性能或效率。煤质问题不仅仅来自于热值参数,还与硬槽可磨性指数有关,硬槽可磨性指数的大小直接影响进炉煤的粒度(细度)。粒径大于标准粒径的影响有:未燃碳多,结渣结垢势增大,煤停留时间延长,影响炉膛出口烟气温度升高。CFD模拟是确定细度对锅炉燃烧特性影响的有效方法。在气相燃烧过程建模中,采用了混合分数法和概率密度函数(PDF)方法。输入和边界条件数据是根据600mwe运行时收集的数据和计算煤耗来确定的。
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引用次数: 0
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THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019
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