THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019最新文献
The racing quadcopter is one of Unmanned Aerial Vehicle (UAV) type which is for high speed. A frame of the racing quadcopter used carbon fiber material because of its lightness and rigidity; however, it is costly. Because of that, it is essential to consider alternative material, such as polylactic acid (PLA). However, the PLA frame needs some optimization treatments to achieve similar mass and rigidity as the carbon fiber. One of the structural optimization methods that can be used is topology optimization. Although this method will generate some intricate details in geometry, which is difficult for conventional manufacturing, however, with the additive manufacturing technology, the complex geometry is no longer a barrier. The aim of this research is prototyping “the best design” frame using a 3D printer, based on simulation results of stress and total deformation of the racing quadcopter from topology optimization method. The methodology started from the quadcopter modeling, initial simulation with carbon fiber frame and PLA frame using the static structural simulation of finite element software. Continued by topology optimization simulation with some retain masses to obtain some redesign models. The next stage is the final simulation on the redesign models using a similar method as the initial simulation, and then the analysis is established to achieve “the best design”. The last stage is model manufacturing using a 3D printer, model testing, and result evaluation. As a result, “the best design” is achieved from doubling the thickness of PLA frame, establishing redesign of 60% retains mass topology optimization. Then both “the best design” manufacturing and testing are done well, although with some defects.
{"title":"Topology optimization on geometry of 3D printed “Impulse RC Alien 4 Inch” racing quadcopter frame with polylactic acid material","authors":"Imang Eko Saputro, A. Wikarta, A. Muhtar","doi":"10.1063/1.5138342","DOIUrl":"https://doi.org/10.1063/1.5138342","url":null,"abstract":"The racing quadcopter is one of Unmanned Aerial Vehicle (UAV) type which is for high speed. A frame of the racing quadcopter used carbon fiber material because of its lightness and rigidity; however, it is costly. Because of that, it is essential to consider alternative material, such as polylactic acid (PLA). However, the PLA frame needs some optimization treatments to achieve similar mass and rigidity as the carbon fiber. One of the structural optimization methods that can be used is topology optimization. Although this method will generate some intricate details in geometry, which is difficult for conventional manufacturing, however, with the additive manufacturing technology, the complex geometry is no longer a barrier. The aim of this research is prototyping “the best design” frame using a 3D printer, based on simulation results of stress and total deformation of the racing quadcopter from topology optimization method. The methodology started from the quadcopter modeling, initial simulation with carbon fiber frame and PLA frame using the static structural simulation of finite element software. Continued by topology optimization simulation with some retain masses to obtain some redesign models. The next stage is the final simulation on the redesign models using a similar method as the initial simulation, and then the analysis is established to achieve “the best design”. The last stage is model manufacturing using a 3D printer, model testing, and result evaluation. As a result, “the best design” is achieved from doubling the thickness of PLA frame, establishing redesign of 60% retains mass topology optimization. Then both “the best design” manufacturing and testing are done well, although with some defects.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"32 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72583717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study of the effect of different frequencies on the irradiance of dental LEDs using pulse width modulation","authors":"Rosalind Fawnia Margeritha, T. Abuzairi","doi":"10.1063/1.5139395","DOIUrl":"https://doi.org/10.1063/1.5139395","url":null,"abstract":"","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77519987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An unhealthy lifestyle could trigger increased levels of cholesterol, hypertension, and obesity, even atherosclerosis. Atherosclerosis is hardening and tightening of the arteries that cause the blocking of blood circulation. Anti-atherosclerosis herbs consist of tanjung leaf (Mimusops elengi L.), starfruit leaf (Averrhoa carambola L.), and temulawak (Curcuma xanthorrhiza R.) are empirically believed has antioxidant, anti-cholesterol, antiplatelets, and anti- hyperglycemic activity. Since anti-atherosclerosis herbs are going to be mass-produced, packaging and herbs stability must be considered carefully to preserve flavonoid content within. Therefore, the expired date information on food packaging is mandatory according to UU No.18/2012 about food and PP No. 69/1999 about food labeling and advertising. The shelf life of anti-atherosclerosis herbs was estimated by accelerated shelf-life test (ASLT) method based on the critical water content approach and sorption isotherms model (Labuza equation). In the study, the organoleptic test and mold test were carried out as well to determine critical condition. Packaging permeability was a parameter in the Labuza equation and was measured by the gravimetric method. The results of this study, the shelf life of anti-atherosclerosis herbs was predicted to be 233 days in filter bag and aluminum foil packaging when it stored at a temperature of 30°C and relative humidity (RH) of 75%.An unhealthy lifestyle could trigger increased levels of cholesterol, hypertension, and obesity, even atherosclerosis. Atherosclerosis is hardening and tightening of the arteries that cause the blocking of blood circulation. Anti-atherosclerosis herbs consist of tanjung leaf (Mimusops elengi L.), starfruit leaf (Averrhoa carambola L.), and temulawak (Curcuma xanthorrhiza R.) are empirically believed has antioxidant, anti-cholesterol, antiplatelets, and anti- hyperglycemic activity. Since anti-atherosclerosis herbs are going to be mass-produced, packaging and herbs stability must be considered carefully to preserve flavonoid content within. Therefore, the expired date information on food packaging is mandatory according to UU No.18/2012 about food and PP No. 69/1999 about food labeling and advertising. The shelf life of anti-atherosclerosis herbs was estimated by accelerated shelf-life test (ASLT) method based on the critical water content approach and sorption isotherms model (Labuza equation). In the stu...
{"title":"Shelf life estimation of anti-atherosclerosis herbs using ASLT: Critical water content and sorption isotherms model","authors":"D. Tristantini, M. Ramadhan, A. Hanifah","doi":"10.1063/1.5139350","DOIUrl":"https://doi.org/10.1063/1.5139350","url":null,"abstract":"An unhealthy lifestyle could trigger increased levels of cholesterol, hypertension, and obesity, even atherosclerosis. Atherosclerosis is hardening and tightening of the arteries that cause the blocking of blood circulation. Anti-atherosclerosis herbs consist of tanjung leaf (Mimusops elengi L.), starfruit leaf (Averrhoa carambola L.), and temulawak (Curcuma xanthorrhiza R.) are empirically believed has antioxidant, anti-cholesterol, antiplatelets, and anti- hyperglycemic activity. Since anti-atherosclerosis herbs are going to be mass-produced, packaging and herbs stability must be considered carefully to preserve flavonoid content within. Therefore, the expired date information on food packaging is mandatory according to UU No.18/2012 about food and PP No. 69/1999 about food labeling and advertising. The shelf life of anti-atherosclerosis herbs was estimated by accelerated shelf-life test (ASLT) method based on the critical water content approach and sorption isotherms model (Labuza equation). In the study, the organoleptic test and mold test were carried out as well to determine critical condition. Packaging permeability was a parameter in the Labuza equation and was measured by the gravimetric method. The results of this study, the shelf life of anti-atherosclerosis herbs was predicted to be 233 days in filter bag and aluminum foil packaging when it stored at a temperature of 30°C and relative humidity (RH) of 75%.An unhealthy lifestyle could trigger increased levels of cholesterol, hypertension, and obesity, even atherosclerosis. Atherosclerosis is hardening and tightening of the arteries that cause the blocking of blood circulation. Anti-atherosclerosis herbs consist of tanjung leaf (Mimusops elengi L.), starfruit leaf (Averrhoa carambola L.), and temulawak (Curcuma xanthorrhiza R.) are empirically believed has antioxidant, anti-cholesterol, antiplatelets, and anti- hyperglycemic activity. Since anti-atherosclerosis herbs are going to be mass-produced, packaging and herbs stability must be considered carefully to preserve flavonoid content within. Therefore, the expired date information on food packaging is mandatory according to UU No.18/2012 about food and PP No. 69/1999 about food labeling and advertising. The shelf life of anti-atherosclerosis herbs was estimated by accelerated shelf-life test (ASLT) method based on the critical water content approach and sorption isotherms model (Labuza equation). In the stu...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"339 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75481809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetic retinopathy (DR) is a diabetes complication causing blindness in which symptoms are not perceived in earlier stage or non-proliferative diabetic retinopathy (NPDR). It is difficult for manual diagnosis methods to keep pace with the growing number of DR. In this study, an algorithm to detect NPDR was developed and implemented in the Android application. In contrary to feature engineering, this study explored a different classification approach by having used a deep neural networks and transfer learning methods on fundus images to train the classifier models. Model development utilized Messidor (4 class) dataset and Messidor-2 (2 class) dataset, image pre-processing, Inception V3 network and MobileNetV1 network, the configuration of test set-train set split, optimizer, and learning rate. Test accuracy of 86% was acquired with InceptionV3 and Messidor-2 which then implemented in Android application. Its yielded accuracy, sensitivity, and specificity are 88%, 80%, and 76% respectively.Diabetic retinopathy (DR) is a diabetes complication causing blindness in which symptoms are not perceived in earlier stage or non-proliferative diabetic retinopathy (NPDR). It is difficult for manual diagnosis methods to keep pace with the growing number of DR. In this study, an algorithm to detect NPDR was developed and implemented in the Android application. In contrary to feature engineering, this study explored a different classification approach by having used a deep neural networks and transfer learning methods on fundus images to train the classifier models. Model development utilized Messidor (4 class) dataset and Messidor-2 (2 class) dataset, image pre-processing, Inception V3 network and MobileNetV1 network, the configuration of test set-train set split, optimizer, and learning rate. Test accuracy of 86% was acquired with InceptionV3 and Messidor-2 which then implemented in Android application. Its yielded accuracy, sensitivity, and specificity are 88%, 80%, and 76% respectively.
{"title":"Development of diabetic retinopathy early detection and its implementation in Android application","authors":"Isca Amanda, H. Zakaria","doi":"10.1063/1.5139396","DOIUrl":"https://doi.org/10.1063/1.5139396","url":null,"abstract":"Diabetic retinopathy (DR) is a diabetes complication causing blindness in which symptoms are not perceived in earlier stage or non-proliferative diabetic retinopathy (NPDR). It is difficult for manual diagnosis methods to keep pace with the growing number of DR. In this study, an algorithm to detect NPDR was developed and implemented in the Android application. In contrary to feature engineering, this study explored a different classification approach by having used a deep neural networks and transfer learning methods on fundus images to train the classifier models. Model development utilized Messidor (4 class) dataset and Messidor-2 (2 class) dataset, image pre-processing, Inception V3 network and MobileNetV1 network, the configuration of test set-train set split, optimizer, and learning rate. Test accuracy of 86% was acquired with InceptionV3 and Messidor-2 which then implemented in Android application. Its yielded accuracy, sensitivity, and specificity are 88%, 80%, and 76% respectively.Diabetic retinopathy (DR) is a diabetes complication causing blindness in which symptoms are not perceived in earlier stage or non-proliferative diabetic retinopathy (NPDR). It is difficult for manual diagnosis methods to keep pace with the growing number of DR. In this study, an algorithm to detect NPDR was developed and implemented in the Android application. In contrary to feature engineering, this study explored a different classification approach by having used a deep neural networks and transfer learning methods on fundus images to train the classifier models. Model development utilized Messidor (4 class) dataset and Messidor-2 (2 class) dataset, image pre-processing, Inception V3 network and MobileNetV1 network, the configuration of test set-train set split, optimizer, and learning rate. Test accuracy of 86% was acquired with InceptionV3 and Messidor-2 which then implemented in Android application. Its yielded accuracy, sensitivity, and specificity are 88%, 80%, and 76% respectively.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"19 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79727123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this research, a bionic prosthetic hand model is designed and built according to the limitations of the human hand, the model is then controlled using a computer algorithm written in MATLAB™ and embedded with Arduino Uno™ based controller. We conduct simulation model by developing algorithm for commanding the system to follow a few arm movement patterns. Forward kinematics algorithm is used to process the user’s input and define control parameters for the bionic arm. The experimental results indicated that the proposed algorithm has already met the desired specifications even though we still require the hardware with high enough specification for actuation purpose.
{"title":"Study on the design of bionic prosthetic hand model","authors":"Gde Pranabhawa Wicaksana, Basari","doi":"10.1063/1.5139384","DOIUrl":"https://doi.org/10.1063/1.5139384","url":null,"abstract":"In this research, a bionic prosthetic hand model is designed and built according to the limitations of the human hand, the model is then controlled using a computer algorithm written in MATLAB™ and embedded with Arduino Uno™ based controller. We conduct simulation model by developing algorithm for commanding the system to follow a few arm movement patterns. Forward kinematics algorithm is used to process the user’s input and define control parameters for the bionic arm. The experimental results indicated that the proposed algorithm has already met the desired specifications even though we still require the hardware with high enough specification for actuation purpose.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85878723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Sutardi, Radiaprima Kartika Wijaya, S. Hariyadi
Flow behavior over a bump attached on a flat plate has significant effect on the total drag. The drag comprises of pressure and friction or viscous drags. Attaching a disturbance on the bump surface affects significantly on the contribution of pressure and viscous drag. This study is intended to examine the effect of a small wire (tripping wire) attachment on a semi-circular bump surface on the flow characteristics over the semi-circular bump. Special attention of this study is to examine the drag characteristics, pressure distribution, and boundary layer separation point from the bump surface. The study was conducted using experimental and numerical methods. The experiments were conducted in a low-speed wind tunnel at a freestream velocity of 16.5 m/s, corresponding to the flow Reynolds number (Re) of approximately 2.1 × 105. Flat plates with a semi-circular bump with and without wire were attached in the wind tunnel test section used as model tests. The wire is attached at three different angle (θ) locations of the bump surface, namely θ = 30 deg, 40 deg, and 50 deg. The pressure distribution on the plate surface as well as on the bump surface is measured using static pressure taps connected to U-tube manometer. From the pressure distribution, then the pressure drag is obtained from the integration of pressure distribution on the surface. Fluid velocity is measured using a Pitot static tube. Numerical studies was conducted using a commercial software the Fluent. A 2-D, steady flow turbulent model k-ω shear-stress transport (SST) was used in this study. In the numerical simulation, the grid independency test is performed to ensure better results. The results of the study show that the presence of a small wire attached on the bump surface increases to the total drag of the model for all values of θ. Also, the boundary layer separation point on the bump surface for all values of θ occurs at smaller angle comparing to that of the bump without wire. Results from the experimental study compare very well to the results obtained from the numerical simulations with a maximum difference of approximately 5 percent. In this study, the maximum drag occurs for the bump with the tripping wire attached at θ = 50 deg.Flow behavior over a bump attached on a flat plate has significant effect on the total drag. The drag comprises of pressure and friction or viscous drags. Attaching a disturbance on the bump surface affects significantly on the contribution of pressure and viscous drag. This study is intended to examine the effect of a small wire (tripping wire) attachment on a semi-circular bump surface on the flow characteristics over the semi-circular bump. Special attention of this study is to examine the drag characteristics, pressure distribution, and boundary layer separation point from the bump surface. The study was conducted using experimental and numerical methods. The experiments were conducted in a low-speed wind tunnel at a freestream velocity of 16.5
{"title":"Experimental and numerical study on the boundary layer flow over a flat plate with a semi-circular bump with and without a transversal wire","authors":"S. Sutardi, Radiaprima Kartika Wijaya, S. Hariyadi","doi":"10.1063/1.5138294","DOIUrl":"https://doi.org/10.1063/1.5138294","url":null,"abstract":"Flow behavior over a bump attached on a flat plate has significant effect on the total drag. The drag comprises of pressure and friction or viscous drags. Attaching a disturbance on the bump surface affects significantly on the contribution of pressure and viscous drag. This study is intended to examine the effect of a small wire (tripping wire) attachment on a semi-circular bump surface on the flow characteristics over the semi-circular bump. Special attention of this study is to examine the drag characteristics, pressure distribution, and boundary layer separation point from the bump surface. The study was conducted using experimental and numerical methods. The experiments were conducted in a low-speed wind tunnel at a freestream velocity of 16.5 m/s, corresponding to the flow Reynolds number (Re) of approximately 2.1 × 105. Flat plates with a semi-circular bump with and without wire were attached in the wind tunnel test section used as model tests. The wire is attached at three different angle (θ) locations of the bump surface, namely θ = 30 deg, 40 deg, and 50 deg. The pressure distribution on the plate surface as well as on the bump surface is measured using static pressure taps connected to U-tube manometer. From the pressure distribution, then the pressure drag is obtained from the integration of pressure distribution on the surface. Fluid velocity is measured using a Pitot static tube. Numerical studies was conducted using a commercial software the Fluent. A 2-D, steady flow turbulent model k-ω shear-stress transport (SST) was used in this study. In the numerical simulation, the grid independency test is performed to ensure better results. The results of the study show that the presence of a small wire attached on the bump surface increases to the total drag of the model for all values of θ. Also, the boundary layer separation point on the bump surface for all values of θ occurs at smaller angle comparing to that of the bump without wire. Results from the experimental study compare very well to the results obtained from the numerical simulations with a maximum difference of approximately 5 percent. In this study, the maximum drag occurs for the bump with the tripping wire attached at θ = 50 deg.Flow behavior over a bump attached on a flat plate has significant effect on the total drag. The drag comprises of pressure and friction or viscous drags. Attaching a disturbance on the bump surface affects significantly on the contribution of pressure and viscous drag. This study is intended to examine the effect of a small wire (tripping wire) attachment on a semi-circular bump surface on the flow characteristics over the semi-circular bump. Special attention of this study is to examine the drag characteristics, pressure distribution, and boundary layer separation point from the bump surface. The study was conducted using experimental and numerical methods. The experiments were conducted in a low-speed wind tunnel at a freestream velocity of 16.5","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85981449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anggia Nurwulan Kusno Putri, S. Arianto, R. Priambodo, Y. Ariani, D. Sjarif
{"title":"Protein analysis of exon 8 mutation in iduronate 2-sulfatase gene in mucopolysaccharidosis type II patients in Indonesia","authors":"Anggia Nurwulan Kusno Putri, S. Arianto, R. Priambodo, Y. Ariani, D. Sjarif","doi":"10.1063/1.5139366","DOIUrl":"https://doi.org/10.1063/1.5139366","url":null,"abstract":"","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84308646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neuropathic (nerve) pain is caused by damage, dysfunction or injury of nerves it will affect patient’s quality of life because of chronicity and intensity. The pharmaceutical drug commonly used to treat neuropathic pain is antidepressants. However, Anti-depressant drug has dangerous side effects if consumed continuously. Herbs treatments use throughout the world for the treatment of neuropathic pain. Jamu Neuropathic Pain Reducer, which consists of aqueous multi herbs extract of nutmeg seed (Myristica fragrans), clove bud (Syzygium aromaticum) and red ginger rhizome (Zingiber officinale var rubrum) was extracted with variation temperature (60, 80, 100 ℃). This study aimed to figure out the total phenolic content (TPC) in the Jamu Neuropathic Pain Reducer used the Folin-Ciocalteu method. The highest TPC (33.58 ± 1.473mg GAE/g herb) happened at temperature 80 ℃. UPLC-QTOF-MS applied to identify the major bioactive compound in Jamu Neuropathic Pain Reducer extract used temperature extraction 80 ℃, analysis revealed the presence of compounds such as adenine, chlorogenic acid, miquelianin, quercitrin, 6-gingerol, myristicin, and eugenol. Jamu Neuropathic Pain Reducer reduced the immobility duration compared with the control negative (distilled water) (p < 0.001). The reductions of the immobility time were 8.3%, 36.4% and 30.1% for dosage 16.25 mL/kg, 32.5 mL/kg and 65 mL/kg, therefore, Jamu Neuropathic Pain Reducer had the potential to be an alternative as herbal medicine for neuropathic pain that less expensive and has minimum side effect.
{"title":"Total phenolic, UPLC-QTOF-MS analysis and antidepressant-like effect in the mice forced swim test of Jamu Neuropathic Pain Reducer","authors":"A. Hanifah, D. Tristantini","doi":"10.1063/1.5139347","DOIUrl":"https://doi.org/10.1063/1.5139347","url":null,"abstract":"Neuropathic (nerve) pain is caused by damage, dysfunction or injury of nerves it will affect patient’s quality of life because of chronicity and intensity. The pharmaceutical drug commonly used to treat neuropathic pain is antidepressants. However, Anti-depressant drug has dangerous side effects if consumed continuously. Herbs treatments use throughout the world for the treatment of neuropathic pain. Jamu Neuropathic Pain Reducer, which consists of aqueous multi herbs extract of nutmeg seed (Myristica fragrans), clove bud (Syzygium aromaticum) and red ginger rhizome (Zingiber officinale var rubrum) was extracted with variation temperature (60, 80, 100 ℃). This study aimed to figure out the total phenolic content (TPC) in the Jamu Neuropathic Pain Reducer used the Folin-Ciocalteu method. The highest TPC (33.58 ± 1.473mg GAE/g herb) happened at temperature 80 ℃. UPLC-QTOF-MS applied to identify the major bioactive compound in Jamu Neuropathic Pain Reducer extract used temperature extraction 80 ℃, analysis revealed the presence of compounds such as adenine, chlorogenic acid, miquelianin, quercitrin, 6-gingerol, myristicin, and eugenol. Jamu Neuropathic Pain Reducer reduced the immobility duration compared with the control negative (distilled water) (p < 0.001). The reductions of the immobility time were 8.3%, 36.4% and 30.1% for dosage 16.25 mL/kg, 32.5 mL/kg and 65 mL/kg, therefore, Jamu Neuropathic Pain Reducer had the potential to be an alternative as herbal medicine for neuropathic pain that less expensive and has minimum side effect.","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78455059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. N. Sommeng, Mustika Sari, M. J. Ginting, M. Sahlan, H. Hermansyah, A. Wijanarko
Lionfish (Pterois volitans) is an invasive species originating from Indo-Pacific Sea. The rapid growth and the absence of natural predators cause Lionfish to breed rapidly and reduce the native fish populations by up to 80%. Therefore, the study of the Lionfish must be intensified to obtain the usefulness of these animals. Studies that have stated that the extract of poison lionfish spines has the potential to become an anticancer agent for cervical cancer. The aim of the present work is to Investigation the Anticancer activity of Pterois volitans from Indonesia to human cervical carcinoma cell (HeLa cell). Crude venom (CV) that is resulted from the extraction process by sonicating of fresh venomous Pterois volitans as a sample was used. The PLA 2 sample of crude venom was heated on (50, 55, 60, 65, 70) °C for 30 min and purified by (20, 40, 60, 80) % ammonium sulfate. The concentration and purity are analyzed using Lowry method, Marinette’s, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and ...
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P. M. Udiyani, A. Hamzah, H. Adrial, S. Kuntjoro, I. Husnayani, M. Setiawan
Experimental Power Reactor (RDE) is a power reactor with High Temperature Gas cooled Reactor (HTGR). The safety justification of the RDE design is that radiation safety can be guaranteed which guarantees the safety of radiation workers and the community around the RDE site. To ensure the safety of workers and the community and the justification that RDE design meets safety criteria, a study of the zoning of the radiation area in the reactor is needed. The assessment is done based on HTR-10 parameters that types and power are similar to RDE. The research was conducted using computer simulation methods using ORIGEN2.1 and MCNP computer programs. Based on the Regulation of BAPETEN No.4 of 2013, concerning "Protection and Safety of Radiation in the Use of Nuclear Power", article 26 of the Work Area is divided into 2 namely Control areas and Supervision area. The zoning of the work area for radiation workers is determined based on the dosage amount calculated from the calculation of radiation sources, doses and radiation shields designed. The division of work area is determined based on the layout of the reactor building which is designed based on the RDE concept design. Based on the RDE concept design, the reactor building is divided into 4 levels, namely: 1). -12.70 m level; 2). Level±0.00 m; 3). Level+12.70 m; and 4). Level +25.40 m. The results of the radiation dose calculation in RDE and the layout of the RDE design are used to determine the zoning area for radiation workers at each level area. Zoning is estimated in accordance with the rules of the BAPETEN regulatory body. Actions that must be taken for each zoning are also carried out.Experimental Power Reactor (RDE) is a power reactor with High Temperature Gas cooled Reactor (HTGR). The safety justification of the RDE design is that radiation safety can be guaranteed which guarantees the safety of radiation workers and the community around the RDE site. To ensure the safety of workers and the community and the justification that RDE design meets safety criteria, a study of the zoning of the radiation area in the reactor is needed. The assessment is done based on HTR-10 parameters that types and power are similar to RDE. The research was conducted using computer simulation methods using ORIGEN2.1 and MCNP computer programs. Based on the Regulation of BAPETEN No.4 of 2013, concerning "Protection and Safety of Radiation in the Use of Nuclear Power", article 26 of the Work Area is divided into 2 namely Control areas and Supervision area. The zoning of the work area for radiation workers is determined based on the dosage amount calculated from the calculation of radiation sources, doses an...
{"title":"The assessment of radiation zone determination in RDE for radiation workers","authors":"P. M. Udiyani, A. Hamzah, H. Adrial, S. Kuntjoro, I. Husnayani, M. Setiawan","doi":"10.1063/1.5135541","DOIUrl":"https://doi.org/10.1063/1.5135541","url":null,"abstract":"Experimental Power Reactor (RDE) is a power reactor with High Temperature Gas cooled Reactor (HTGR). The safety justification of the RDE design is that radiation safety can be guaranteed which guarantees the safety of radiation workers and the community around the RDE site. To ensure the safety of workers and the community and the justification that RDE design meets safety criteria, a study of the zoning of the radiation area in the reactor is needed. The assessment is done based on HTR-10 parameters that types and power are similar to RDE. The research was conducted using computer simulation methods using ORIGEN2.1 and MCNP computer programs. Based on the Regulation of BAPETEN No.4 of 2013, concerning \"Protection and Safety of Radiation in the Use of Nuclear Power\", article 26 of the Work Area is divided into 2 namely Control areas and Supervision area. The zoning of the work area for radiation workers is determined based on the dosage amount calculated from the calculation of radiation sources, doses and radiation shields designed. The division of work area is determined based on the layout of the reactor building which is designed based on the RDE concept design. Based on the RDE concept design, the reactor building is divided into 4 levels, namely: 1). -12.70 m level; 2). Level±0.00 m; 3). Level+12.70 m; and 4). Level +25.40 m. The results of the radiation dose calculation in RDE and the layout of the RDE design are used to determine the zoning area for radiation workers at each level area. Zoning is estimated in accordance with the rules of the BAPETEN regulatory body. Actions that must be taken for each zoning are also carried out.Experimental Power Reactor (RDE) is a power reactor with High Temperature Gas cooled Reactor (HTGR). The safety justification of the RDE design is that radiation safety can be guaranteed which guarantees the safety of radiation workers and the community around the RDE site. To ensure the safety of workers and the community and the justification that RDE design meets safety criteria, a study of the zoning of the radiation area in the reactor is needed. The assessment is done based on HTR-10 parameters that types and power are similar to RDE. The research was conducted using computer simulation methods using ORIGEN2.1 and MCNP computer programs. Based on the Regulation of BAPETEN No.4 of 2013, concerning \"Protection and Safety of Radiation in the Use of Nuclear Power\", article 26 of the Work Area is divided into 2 namely Control areas and Supervision area. The zoning of the work area for radiation workers is determined based on the dosage amount calculated from the calculation of radiation sources, doses an...","PeriodicalId":22239,"journal":{"name":"THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85448105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019
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