I. Kovačević, Mladen Bila, J. Mirkovic, I. Mišić, Jelena Vasilijević
Introduction/Objective. Ocular trauma is a globally important cause of visual impairment. The aim of our study was to analyses demographic, epidemiological and clinical characteristics of blunt ocular trauma. Methods. The retrospective study enrolled patients with blunt ocular trauma, hospitalized at the Eye Clinic, University Clinical Center of Serbia in Belgrade in a four-year period (2018-2022). Demographic characteristics, mechanism of injury, best corrected visual acuity on admission and discharge and injured eye structure were analyzed. Results. Out of 283 patients, the majority (n = 233.82%) were men. People aged 61 and over (n = 82.29%) were at greatest risk for blunt ocular trauma. Injuries from splitting wood (n = 78.28%) and various blunt tools and objects (n = 70.25%) were the most common mechanism in the entire study group, both in men and in women. Visual acuity on admission was better than 0.6 in 147 (52%) patients and at discharge in 185 (65%). The most common eye structure affected are pathological findings in anterior chamber (n = 160.56%), which are mainly related to hyphemia. Conclusion. Present study showed that blunt ocular trauma affects all age groups, but most often elderly and children. Men are injured more often than women. Splitting wood and manipulating blunt tools and objects are activities with the highest risk of blunt ocular trauma.
{"title":"The epidemiology of blunt ocular trauma in a tertiary health care institution in Serbia - a four-year-long retrospective study","authors":"I. Kovačević, Mladen Bila, J. Mirkovic, I. Mišić, Jelena Vasilijević","doi":"10.2298/sarh220929024k","DOIUrl":"https://doi.org/10.2298/sarh220929024k","url":null,"abstract":"Introduction/Objective. Ocular trauma is a globally important cause of visual impairment. The aim of our study was to analyses demographic, epidemiological and clinical characteristics of blunt ocular trauma. Methods. The retrospective study enrolled patients with blunt ocular trauma, hospitalized at the Eye Clinic, University Clinical Center of Serbia in Belgrade in a four-year period (2018-2022). Demographic characteristics, mechanism of injury, best corrected visual acuity on admission and discharge and injured eye structure were analyzed. Results. Out of 283 patients, the majority (n = 233.82%) were men. People aged 61 and over (n = 82.29%) were at greatest risk for blunt ocular trauma. Injuries from splitting wood (n = 78.28%) and various blunt tools and objects (n = 70.25%) were the most common mechanism in the entire study group, both in men and in women. Visual acuity on admission was better than 0.6 in 147 (52%) patients and at discharge in 185 (65%). The most common eye structure affected are pathological findings in anterior chamber (n = 160.56%), which are mainly related to hyphemia. Conclusion. Present study showed that blunt ocular trauma affects all age groups, but most often elderly and children. Men are injured more often than women. Splitting wood and manipulating blunt tools and objects are activities with the highest risk of blunt ocular trauma.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"304 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68729512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Todorović, S. Dugalić, Maja Macura, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, J. Micic, I. Pantić, M. Perović, B. Parapid, M. Gojnić
It has been an entire century since the introduction of insulin into clinical practice, which, among other, led to fertility and pregnancy outcomes? improvements. The prevalence of diabetes worldwide and in Serbia is high and tends to increase as a consequence of modern lifestyle. Nevertheless, modern diagnostic and therapeutically approaches enable people with diabetes to achieve and complete pregnancies without adverse outcomes. Gestational diabetes can be considered as non-communicable disease and efforts should be made to determine its effects on the offspring. In the context of COVID-19 pandemic, diabetes mellitus was identified as an important risk factor for severe forms of the disease.
{"title":"Historical aspects of diabetes, morbidity and mortality","authors":"J. Todorović, S. Dugalić, Maja Macura, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, J. Micic, I. Pantić, M. Perović, B. Parapid, M. Gojnić","doi":"10.2298/sarh221021013t","DOIUrl":"https://doi.org/10.2298/sarh221021013t","url":null,"abstract":"It has been an entire century since the introduction of insulin into clinical practice, which, among other, led to fertility and pregnancy outcomes? improvements. The prevalence of diabetes worldwide and in Serbia is high and tends to increase as a consequence of modern lifestyle. Nevertheless, modern diagnostic and therapeutically approaches enable people with diabetes to achieve and complete pregnancies without adverse outcomes. Gestational diabetes can be considered as non-communicable disease and efforts should be made to determine its effects on the offspring. In the context of COVID-19 pandemic, diabetes mellitus was identified as an important risk factor for severe forms of the disease.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68729820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Shabani, O. Ivanovski, S. Gurmeshevski, Armend Rufati, A. Panovska-Petrusheva, Vita Stojmenovska, G. Petrushevska
Introduction/Objective Radical prostatectomy is a treatment option with high curative potential in patients with prostate cancer of moderate-risk. The aim of the study is to assess perioperative results of laparoscopic (LRP) and open retropubic radical prostatectomy (ORRP). Methods From 2016 to 2020, a total of 244 patients undergone RP, as follow: 145 patients LRP and 99 patients ORRP. Demographic data, preoperative parameters, perioperative and pathological outcomes were analyzed and compared among LRP and ORRP groups. Results In regard to demographic data and preoperative parameters (BMI, mean age, median pretreatment PSA, clinical stage and Gleason score from biopsy), there are no differences between the observed groups. Patients from ORRP group had significantly shorter operative time (p < 0.05). Patients from LRP group had major advantages in regard to estimated blood loss (EBL) (550 ml for LRP vs. 1450 ml for ORRP), hospitalization time (six days for LRP vs. nine days for ORRP), catheter removal (6.5 days for LRP vs. 12 days for ORRP), overall complication rates (29% for LRP vs. 48.4% for ORRP) and blood transfusion rates (22.7% for LRP and 37.4% for ORRP). Conclusion Both LRP and ORRP provide favorable operative results in terms of efficacy, safety and oncologic outcome. However, patients undergoing LRP were more likely to have less EBL, shorter length of hospital stay, earlier catheter removal and lower rates of overall perioperative complications.
简介/目的根治性前列腺切除术是中危前列腺癌患者的一种治疗选择，具有很高的治愈潜力。本研究的目的是评估腹腔镜(LRP)和开放式耻骨后根治性前列腺切除术(ORRP)的围手术期效果。方法2016 - 2020年共244例患者行RP，其中LRP 145例，ORRP 99例。分析比较LRP组和ORRP组的人口学资料、术前参数、围手术期及病理结果。结果在人口学数据和术前参数(BMI、平均年龄、预处理PSA中位数、临床分期和活检Gleason评分)方面，观察组间无差异。ORRP组患者手术时间明显缩短(p < 0.05)。LRP组患者在估计失血量(EBL) (LRP组550 ml vs ORRP组1450 ml)、住院时间(LRP组6天vs ORRP组9天)、拔管(LRP组6.5天vs ORRP组12天)、总并发症发生率(LRP组29% vs ORRP组48.4%)和输血率(LRP组22.7% vs ORRP组37.4%)方面具有主要优势。结论LRP和ORRP在疗效、安全性和肿瘤预后方面均具有良好的手术效果。然而，接受LRP的患者更有可能发生更少的EBL，更短的住院时间，更早的拔管和更低的围手术期并发症发生率。
{"title":"Perioperative outcomes of laparoscopic and open retropubic radical prostatectomy","authors":"B. Shabani, O. Ivanovski, S. Gurmeshevski, Armend Rufati, A. Panovska-Petrusheva, Vita Stojmenovska, G. Petrushevska","doi":"10.2298/sarh230404054s","DOIUrl":"https://doi.org/10.2298/sarh230404054s","url":null,"abstract":"Introduction/Objective Radical prostatectomy is a treatment option with high curative potential in patients with prostate cancer of moderate-risk. The aim of the study is to assess perioperative results of laparoscopic (LRP) and open retropubic radical prostatectomy (ORRP). Methods From 2016 to 2020, a total of 244 patients undergone RP, as follow: 145 patients LRP and 99 patients ORRP. Demographic data, preoperative parameters, perioperative and pathological outcomes were analyzed and compared among LRP and ORRP groups. Results In regard to demographic data and preoperative parameters (BMI, mean age, median pretreatment PSA, clinical stage and Gleason score from biopsy), there are no differences between the observed groups. Patients from ORRP group had significantly shorter operative time (p < 0.05). Patients from LRP group had major advantages in regard to estimated blood loss (EBL) (550 ml for LRP vs. 1450 ml for ORRP), hospitalization time (six days for LRP vs. nine days for ORRP), catheter removal (6.5 days for LRP vs. 12 days for ORRP), overall complication rates (29% for LRP vs. 48.4% for ORRP) and blood transfusion rates (22.7% for LRP and 37.4% for ORRP). Conclusion Both LRP and ORRP provide favorable operative results in terms of efficacy, safety and oncologic outcome. However, patients undergoing LRP were more likely to have less EBL, shorter length of hospital stay, earlier catheter removal and lower rates of overall perioperative complications.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68732375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction/Objective. Invasive candidiasis (IC) is the most common invasive fungal infection in humans. It manifests as candidemia, and can affect internal organs and lead to sepsis and septic shock. A good knowledge of the factors that lead to the morbidity and mortality of these patients is necessary. We aimed to investigate the factors associated with the unfavorable outcome of patients with IC treated in our institution. Methods. The research was conducted at the Military Medical Academy in Belgrade, Serbia. The retrospective cohort study included 145 patients of both sexes, aged over 18 years, with a proven diagnosis of invasive candidiasis. Demographics, comorbidities, use of therapeutic procedures, antibiotics, antifungal treatment and outcome were compared between deceased and surviving patients with invasive candidiasis. The results were analyzed using Student's t-test, Mann-Whitney U test, multivariate statistical analysis. Results. The results showed that the predictors of death were DM (adjusted OR 6.886; CI 2.608-18.178; p = 0.000) and chemotherapy (adjusted OR 6.826; 95% CI: 2.037-22.866; p = 0.002), which increase the risk for death seven times compared to the basal risk and mechanical ventilation, which increases the risk of death about three times (adjusted OR: 3.056; 95% CI: 1.132-8.253; p = 0.012). Conclusion. Optimal treatment is necessary in terms of early detection and identification of the causative agent of IC. In susceptible patients, such as immunocompromised patients, appropriate treatment should be initiated as soon as possible.
{"title":"Factors’ analysis associated with adverse outcome of the treatment of patients with invasive candidiasis","authors":"Svetlana Popovic, Vesna Begovic-Kupresanin","doi":"10.2298/sarh230804087p","DOIUrl":"https://doi.org/10.2298/sarh230804087p","url":null,"abstract":"Introduction/Objective. Invasive candidiasis (IC) is the most common invasive fungal infection in humans. It manifests as candidemia, and can affect internal organs and lead to sepsis and septic shock. A good knowledge of the factors that lead to the morbidity and mortality of these patients is necessary. We aimed to investigate the factors associated with the unfavorable outcome of patients with IC treated in our institution. Methods. The research was conducted at the Military Medical Academy in Belgrade, Serbia. The retrospective cohort study included 145 patients of both sexes, aged over 18 years, with a proven diagnosis of invasive candidiasis. Demographics, comorbidities, use of therapeutic procedures, antibiotics, antifungal treatment and outcome were compared between deceased and surviving patients with invasive candidiasis. The results were analyzed using Student's t-test, Mann-Whitney U test, multivariate statistical analysis. Results. The results showed that the predictors of death were DM (adjusted OR 6.886; CI 2.608-18.178; p = 0.000) and chemotherapy (adjusted OR 6.826; 95% CI: 2.037-22.866; p = 0.002), which increase the risk for death seven times compared to the basal risk and mechanical ventilation, which increases the risk of death about three times (adjusted OR: 3.056; 95% CI: 1.132-8.253; p = 0.012). Conclusion. Optimal treatment is necessary in terms of early detection and identification of the causative agent of IC. In susceptible patients, such as immunocompromised patients, appropriate treatment should be initiated as soon as possible.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135840357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jovan Bila, Jelena Dotlic, Ljubisa Jovanovic, Milan Dokic, Tatjana Madic
Introduction. Spontaneous bilateral ectopic pregnancy is a rare condition easily overlooked or misdiagnosed. We present a case of spontaneous bilateral tubal ectopic pregnancy and discuss the difficulties in diagnosing and treatment of such patients. Case outline. A 39-years-old patient with history of irregular and abundant menstrual cycles complained on pelvic pain and light bleeding after 55 days of amenorrhea. Ultrasound revealed enlarged uterus with a myoma and a heterogenic formation with echogenic ring sign beside the left ovary. Free fluid with cloths was present in the pelvis. As the patient was hemodynamically unstable and ectopic pregnancy was suspected emergency laparotomy was performed. During surgery we found that both tubes were significantly edematous, dilated and livid in their ampullary regions. On the left tube anterior wall rupture 15 ? 8 mm was noticeable, while right tube was intact with bleeding from its abdominal ostium. Even though the patient was not informed about the possibility of bilateral salpingectomy, after thorough consideration and due to the extent of tubal damage bilateral salpingectomy was eventually performed. Histopathological analysis confirmed presence of decidua, partially viable and partially necrotic chorionic villi and trophoblastic tissue in both left and right tube. Conclusions. Careful preoperative and intraoperative examination of both Fallopian tubes as well as the whole abdominal and pelvic cavity should be mandatory during every assessment of patients with ectopic pregnancy.
{"title":"Spontaneous bilateral tubal pregnancy - case report and review of diagnostic and treatment difficulties","authors":"Jovan Bila, Jelena Dotlic, Ljubisa Jovanovic, Milan Dokic, Tatjana Madic","doi":"10.2298/sarh221227086b","DOIUrl":"https://doi.org/10.2298/sarh221227086b","url":null,"abstract":"Introduction. Spontaneous bilateral ectopic pregnancy is a rare condition easily overlooked or misdiagnosed. We present a case of spontaneous bilateral tubal ectopic pregnancy and discuss the difficulties in diagnosing and treatment of such patients. Case outline. A 39-years-old patient with history of irregular and abundant menstrual cycles complained on pelvic pain and light bleeding after 55 days of amenorrhea. Ultrasound revealed enlarged uterus with a myoma and a heterogenic formation with echogenic ring sign beside the left ovary. Free fluid with cloths was present in the pelvis. As the patient was hemodynamically unstable and ectopic pregnancy was suspected emergency laparotomy was performed. During surgery we found that both tubes were significantly edematous, dilated and livid in their ampullary regions. On the left tube anterior wall rupture 15 ? 8 mm was noticeable, while right tube was intact with bleeding from its abdominal ostium. Even though the patient was not informed about the possibility of bilateral salpingectomy, after thorough consideration and due to the extent of tubal damage bilateral salpingectomy was eventually performed. Histopathological analysis confirmed presence of decidua, partially viable and partially necrotic chorionic villi and trophoblastic tissue in both left and right tube. Conclusions. Careful preoperative and intraoperative examination of both Fallopian tubes as well as the whole abdominal and pelvic cavity should be mandatory during every assessment of patients with ectopic pregnancy.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135841027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivanka Lukić, J. Antić, V. Trajkovic, S. Bukarica, Ján Varga, Mihajlo Jeckovic
Introduction/Objective. Studies about possibilities of conservative, i.e. non-operative management of acute uncomplicated appendicitis in adult and pediatric population have been published lately, considering benefits of preserving appendix and potential complications related to appendectomy. Methods. In this retrospective study medical data of 76 patients treated at the Institute for Child and Youth Health Care of Vojvodina in Novi Sad for acute uncomplicated appendicitis in 2015 and 2016 have been analysed, comparing length of stay, antibiotic therapy use, complications occurement, as well as the financial burden depending of the type of therapy applied. Results. During this period, 76 patients (55 operated and 21 treated conservatively) were treated for acute uncomplicated appendicitis. Conservatively treated children spent statistically significantly shorter period of time at the hospital compared to the operated ones (4.24 vs. 5.76 days; p < 0.001). Early surgical complications occurred in 10.91% operated and 9.52% non-operated children, which wasn?t statistically significant difference (p = 0.863). The total cost of hospital stay was significantly lower in those who underwent non-operative management (10,340 RSD vs. 54,281 RSD; p = 0). The difference was significant even when analyzing costs related to rehospitalization and operative treatment of children initially treated conservatively (p < 0.001). Conclusion. Non-operative i.e. conservative treatment of acute uncomplicated appendicitis in the pediatric population is safe and effective compared to the operative one, and it is not associated with more frequent occurrence of early surgical complications. Total costs for the non-operative treatment are significantly lower, even considering costs related to re-hospitalization of children initially treated conservatively.
{"title":"Comparison of conservative and operative treatment of uncomplicated appendicitis in the pediatric population","authors":"Ivanka Lukić, J. Antić, V. Trajkovic, S. Bukarica, Ján Varga, Mihajlo Jeckovic","doi":"10.2298/sarh220708015l","DOIUrl":"https://doi.org/10.2298/sarh220708015l","url":null,"abstract":"Introduction/Objective. Studies about possibilities of conservative, i.e. non-operative management of acute uncomplicated appendicitis in adult and pediatric population have been published lately, considering benefits of preserving appendix and potential complications related to appendectomy. Methods. In this retrospective study medical data of 76 patients treated at the Institute for Child and Youth Health Care of Vojvodina in Novi Sad for acute uncomplicated appendicitis in 2015 and 2016 have been analysed, comparing length of stay, antibiotic therapy use, complications occurement, as well as the financial burden depending of the type of therapy applied. Results. During this period, 76 patients (55 operated and 21 treated conservatively) were treated for acute uncomplicated appendicitis. Conservatively treated children spent statistically significantly shorter period of time at the hospital compared to the operated ones (4.24 vs. 5.76 days; p < 0.001). Early surgical complications occurred in 10.91% operated and 9.52% non-operated children, which wasn?t statistically significant difference (p = 0.863). The total cost of hospital stay was significantly lower in those who underwent non-operative management (10,340 RSD vs. 54,281 RSD; p = 0). The difference was significant even when analyzing costs related to rehospitalization and operative treatment of children initially treated conservatively (p < 0.001). Conclusion. Non-operative i.e. conservative treatment of acute uncomplicated appendicitis in the pediatric population is safe and effective compared to the operative one, and it is not associated with more frequent occurrence of early surgical complications. Total costs for the non-operative treatment are significantly lower, even considering costs related to re-hospitalization of children initially treated conservatively.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68728975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Lekovic, Vladimir Radlović, Marija Mladenovic, S. Dučić, Goran J Djuričić, Jelica Predojević-Samardžić, Biljana Vuletić, Petar Rosic, S. Janković, N. Radlović
Introduction/Objective Celiac disease (CD) is the result of a polygenic predisposition and gluten-containing diet. The aim of this study was to determine the prevalence and clinical forms of CD in siblings of children with verified disease. Methods The study included 83 siblings, aged 1.5-27 (11.77 ? 6.2) years, from 64 children with CB diagnosed according to ESPGHAN criteria (1990/2012). In addition to a detailed history and clinical examination, serum levels of IgA and antibodies to tissue transglutaminase (AtTG) IgA and IgG classes were determined in all subjects. All with elevated AtTG levels underwent multiple duodenal enterobiopsy. The diagnosis of CD was confirmed by the finding of characteristic histological changes. Results The diagnosis of CB was made in 13 of 83 subjects (15.67%). Nine of them had an asymptomatic form of the disease, while in the others the disease was clinically manifest, in 3 classical, in one accompanied by severe malnutrition (-26.80%) and in one nonclassical (only short stature). Except for sideropenia and and hypoferritinemia in 4 patients, of which 2 with hemoglobin below the reference value, standard laboratory findings were within normal limits. Conclusion Our research shows that the prevalence of CB in siblings of children with verified disease is 15.67%. It is mostly detected in asymptomatic form. In accordance with this, the necessity of routine application of serological screening for CB in this population group in order to its timely diagnosis and treatment.
{"title":"Prevalence and clinical forms of celiac disease in siblings of children with verified disease","authors":"Z. Lekovic, Vladimir Radlović, Marija Mladenovic, S. Dučić, Goran J Djuričić, Jelica Predojević-Samardžić, Biljana Vuletić, Petar Rosic, S. Janković, N. Radlović","doi":"10.2298/sarh221206049l","DOIUrl":"https://doi.org/10.2298/sarh221206049l","url":null,"abstract":"Introduction/Objective Celiac disease (CD) is the result of a polygenic predisposition and gluten-containing diet. The aim of this study was to determine the prevalence and clinical forms of CD in siblings of children with verified disease. Methods The study included 83 siblings, aged 1.5-27 (11.77 ? 6.2) years, from 64 children with CB diagnosed according to ESPGHAN criteria (1990/2012). In addition to a detailed history and clinical examination, serum levels of IgA and antibodies to tissue transglutaminase (AtTG) IgA and IgG classes were determined in all subjects. All with elevated AtTG levels underwent multiple duodenal enterobiopsy. The diagnosis of CD was confirmed by the finding of characteristic histological changes. Results The diagnosis of CB was made in 13 of 83 subjects (15.67%). Nine of them had an asymptomatic form of the disease, while in the others the disease was clinically manifest, in 3 classical, in one accompanied by severe malnutrition (-26.80%) and in one nonclassical (only short stature). Except for sideropenia and and hypoferritinemia in 4 patients, of which 2 with hemoglobin below the reference value, standard laboratory findings were within normal limits. Conclusion Our research shows that the prevalence of CB in siblings of children with verified disease is 15.67%. It is mostly detected in asymptomatic form. In accordance with this, the necessity of routine application of serological screening for CB in this population group in order to its timely diagnosis and treatment.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68730869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maja Macura, S. Dugalić, J. Todorović, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, I. Soldatovic, I. Pantić, M. Perović, B. Parapid, M. Gojnić
In order to enhance cost-benefit value of the gestational diabetes mellitus screening (GDM) the concept of universal screening i.e., screening of all pregnant women for gestational diabetes, has mostly been abandoned in favor of the concept of selective screening. Selective screening implies that only women with risk factors are being screened for GDM. However, some recent studies have shown that with the application of the selective screening approach, some women with GDM may not receive proper and timely diagnosis. This review addresses the pros and cons of both concepts. It will also discuss screening methods and methods of preparation and performance of oral glucose tolerance test (OGTT) and the interpretation of its results.
{"title":"Historical and statistical aspects of risk groups analysis and testing in the context of gestational diabetes mellitus","authors":"Maja Macura, S. Dugalić, J. Todorović, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, I. Soldatovic, I. Pantić, M. Perović, B. Parapid, M. Gojnić","doi":"10.2298/sarh221212008m","DOIUrl":"https://doi.org/10.2298/sarh221212008m","url":null,"abstract":"In order to enhance cost-benefit value of the gestational diabetes mellitus screening (GDM) the concept of universal screening i.e., screening of all pregnant women for gestational diabetes, has mostly been abandoned in favor of the concept of selective screening. Selective screening implies that only women with risk factors are being screened for GDM. However, some recent studies have shown that with the application of the selective screening approach, some women with GDM may not receive proper and timely diagnosis. This review addresses the pros and cons of both concepts. It will also discuss screening methods and methods of preparation and performance of oral glucose tolerance test (OGTT) and the interpretation of its results.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68730901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Pavlović, T. Ristić, Dusanka Markovic, A. Ignjatović, A. Karanikolić, M. Djordjevic, Milica D. Radić, Ljubimir Dinic, D. Laketic
Introduction/Objective Rib fractures are common in blunt chest trauma (BTC) and when they are associated with pleural complications (PC) - pneumothorax, hemothorax and hemopneumothorax the treatment of these patients is prolonged and difficult. Without the ability to predict PC after rib fractures in BTC, most doctors are forced to initially treat these patients through observation and conservative treatment. The goal of this research is to determine which of the investigated biomarkers of inflammation - fibrinogen, IL-6 and CRP are significantly associated with the occurrence of PC after rib fracture in BCT, which would be used in stratifying patients for hospitalization and further treatment. Methods The prospective study included 90 patients with rib fractures caused by BTC. The test group comprised 45 patients with rib fractures and the presence of PC, and the control group consisted of 45 patients with rib fractures without PC. Blood sampling was performed on admission, on the second, third and fifth day after the injury, and PC were monitored until the seventh day after the injury. Results Serum values of IL-6 on the second day and fibrinogen and CRP on the second and third day after injury were statistically significantly higher in patients with PC, and IL-6 showed a good discriminative ability in assessing the occurrence of PC on the second day after a rib fracture in BTC. Conclusion The investigated biomarkers of inflammation - fibrinogen, IL-6 and CRP can be used as predictors of PC after rib fracture in BTC, and their application can significantly replace clinical observation.
{"title":"Significance of fibrinogen, interleukin-6, and C-reactive protein as predictors of pleural complications after rib fractures in blunt chest trauma","authors":"M. Pavlović, T. Ristić, Dusanka Markovic, A. Ignjatović, A. Karanikolić, M. Djordjevic, Milica D. Radić, Ljubimir Dinic, D. Laketic","doi":"10.2298/sarh221221073p","DOIUrl":"https://doi.org/10.2298/sarh221221073p","url":null,"abstract":"Introduction/Objective Rib fractures are common in blunt chest trauma (BTC) and when they are associated with pleural complications (PC) - pneumothorax, hemothorax and hemopneumothorax the treatment of these patients is prolonged and difficult. Without the ability to predict PC after rib fractures in BTC, most doctors are forced to initially treat these patients through observation and conservative treatment. The goal of this research is to determine which of the investigated biomarkers of inflammation - fibrinogen, IL-6 and CRP are significantly associated with the occurrence of PC after rib fracture in BCT, which would be used in stratifying patients for hospitalization and further treatment. Methods The prospective study included 90 patients with rib fractures caused by BTC. The test group comprised 45 patients with rib fractures and the presence of PC, and the control group consisted of 45 patients with rib fractures without PC. Blood sampling was performed on admission, on the second, third and fifth day after the injury, and PC were monitored until the seventh day after the injury. Results Serum values of IL-6 on the second day and fibrinogen and CRP on the second and third day after injury were statistically significantly higher in patients with PC, and IL-6 showed a good discriminative ability in assessing the occurrence of PC on the second day after a rib fracture in BTC. Conclusion The investigated biomarkers of inflammation - fibrinogen, IL-6 and CRP can be used as predictors of PC after rib fracture in BTC, and their application can significantly replace clinical observation.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68731407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Glide path is a procedure that precedes mechanical instrumentation of the root canals. It is defined as a procedure used to expand or create a smooth tunnel from the coronal part of the root canal to its physiological terminus. It is performed using small sized hand files or specially designed mechanical NiTi instruments. An adequately created glide path extends the life of rotary NiTi instruments, enables better mechanical and chemical debridement and easier preservation of original morphology of endodontic space during further mechanical instrumentation. Frequent use of mechanical instrumentation in daily practice requires better understanding of glide path, its significance, and instruments and techniques used for its creation.
{"title":"Endodontic glide path - importance and performance techniques","authors":"Milica Jovanovic-Medojevic, Мiljan Stosic, Vanja Opacic-Galic, Violeta Petrovic","doi":"10.2298/sarh230113038j","DOIUrl":"https://doi.org/10.2298/sarh230113038j","url":null,"abstract":"Glide path is a procedure that precedes mechanical instrumentation of the root canals. It is defined as a procedure used to expand or create a smooth tunnel from the coronal part of the root canal to its physiological terminus. It is performed using small sized hand files or specially designed mechanical NiTi instruments. An adequately created glide path extends the life of rotary NiTi instruments, enables better mechanical and chemical debridement and easier preservation of original morphology of endodontic space during further mechanical instrumentation. Frequent use of mechanical instrumentation in daily practice requires better understanding of glide path, its significance, and instruments and techniques used for its creation.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68731776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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