Nedeljko Radlovic, Zoran Lekovic, Marija Mladenovic, Biljana Vuletic, Jelena Radlovic, Sinisa Ducic, Dejan Nikolic
Celiac disease is a multisystemic autoimmune disease induced by gluten in wheat, rye and barley. It is characterized by polygenic predisposition, prevailing prevalence in members of the white population (1%), especially in close relatives (5-15%), very heterogeneous expression and frequent association with other autoimmune diseases (3-10%), as well as selective deficiency of IgA and Down, Turner and Williams syndromes. The basis of the disease and the key finding in its diagnostics is gluten-sensitive enteropathy, i.e., non-specific inflammation of the small intestinal mucosa which resolves by gluten-free diet. In addition to enteropathy, whether symptomatic or asymptomatic, the disease is also characterized by various extraintestinal manifestations, and even very serious complications. Therapy is based on a lifelong gluten-free diet, so that the disorder, if diagnosed in time and treated consistently, has an excellent prognosis.
{"title":"Celiac disease - a comprehensive review","authors":"Nedeljko Radlovic, Zoran Lekovic, Marija Mladenovic, Biljana Vuletic, Jelena Radlovic, Sinisa Ducic, Dejan Nikolic","doi":"10.2298/sarh230716098r","DOIUrl":"https://doi.org/10.2298/sarh230716098r","url":null,"abstract":"Celiac disease is a multisystemic autoimmune disease induced by gluten in wheat, rye and barley. It is characterized by polygenic predisposition, prevailing prevalence in members of the white population (1%), especially in close relatives (5-15%), very heterogeneous expression and frequent association with other autoimmune diseases (3-10%), as well as selective deficiency of IgA and Down, Turner and Williams syndromes. The basis of the disease and the key finding in its diagnostics is gluten-sensitive enteropathy, i.e., non-specific inflammation of the small intestinal mucosa which resolves by gluten-free diet. In addition to enteropathy, whether symptomatic or asymptomatic, the disease is also characterized by various extraintestinal manifestations, and even very serious complications. Therapy is based on a lifelong gluten-free diet, so that the disorder, if diagnosed in time and treated consistently, has an excellent prognosis.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135561034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Borislav Toskovic, Vladimir Milosavljevic, Matija Buzejic, Natasa Stanisavljevic, Darko Zdravkovic
Introduction. Most patients with liver hemangiomas are unrecognized, when symptoms occur it is usually due to its size. Hemangioma of liver are benign tumors which affects more often women. Surgical indications for liver resection remain unclear. Case outline. We present a patient with giant hemangioma of left liver lobe that was misdiagnosed in primary care unit. Patient underwent resection of left liver lobe and fully recovered a few days after. Conclusion. Symptoms, size, and risk of rupture should be considered when decision for operation is made. Linear stapler can be useful especially when left and middle hepatic vein have common trunk.
{"title":"Misdiagnosed giant left lobe hemangioma of liver for splenomegaly","authors":"Borislav Toskovic, Vladimir Milosavljevic, Matija Buzejic, Natasa Stanisavljevic, Darko Zdravkovic","doi":"10.2298/sarh230904101t","DOIUrl":"https://doi.org/10.2298/sarh230904101t","url":null,"abstract":"Introduction. Most patients with liver hemangiomas are unrecognized, when symptoms occur it is usually due to its size. Hemangioma of liver are benign tumors which affects more often women. Surgical indications for liver resection remain unclear. Case outline. We present a patient with giant hemangioma of left liver lobe that was misdiagnosed in primary care unit. Patient underwent resection of left liver lobe and fully recovered a few days after. Conclusion. Symptoms, size, and risk of rupture should be considered when decision for operation is made. Linear stapler can be useful especially when left and middle hepatic vein have common trunk.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135609912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. There is a high prevalence of psychiatric disorders in patients who are preparing for metabolic operation especially depression. Mini/one anastomosis gastric bypass (MGB/OAGB) is a bariatric operation with the possibility of complete restoration of the digestive tract or ?tailoring? of a biliopancreatic limb if the patient's weight regains. We present an obese patient with depression who underwent the first MGB/OAGB in Serbia with a follow-up period of one year. Case outline. An obese patient with a body weight of 144 kilograms and a body mass index (BMI) of 46.8 kg/m2 and depression as an accompanying comorbidity, underwent MGB/OAGB with a follow-up period of one year. The operation was performed using the inventor's technique in his presence and the recovery was uneventful. The patient completely stops taking psychiatric therapy, or any other, with no compliance and has completely social restitution. After the follow-up period, he loses 49 kg, actually BMI = 30. 9 kg/m? and the percentage of excess weight loss (%EWL) is 73.1 %. Conclusion. In psychiatric obese patients, a metabolic procedure should be carefully selected. MGB/OAGB proved to be a successful bariatric procedure in our patient, leading to remission of depression and discontinuation of psychiatric therapy, but also to a significant reduction in body weight in the period of one year after surgery.
{"title":"Mini/one anastomosis gastric bypass in an obese depressive patient","authors":"M. Ilic, S. Putnik","doi":"10.2298/sarh220212029i","DOIUrl":"https://doi.org/10.2298/sarh220212029i","url":null,"abstract":"Introduction. There is a high prevalence of psychiatric disorders in patients who are preparing for metabolic operation especially depression. Mini/one anastomosis gastric bypass (MGB/OAGB) is a bariatric operation with the possibility of complete restoration of the digestive tract or ?tailoring? of a biliopancreatic limb if the patient's weight regains. We present an obese patient with depression who underwent the first MGB/OAGB in Serbia with a follow-up period of one year. Case outline. An obese patient with a body weight of 144 kilograms and a body mass index (BMI) of 46.8 kg/m2 and depression as an accompanying comorbidity, underwent MGB/OAGB with a follow-up period of one year. The operation was performed using the inventor's technique in his presence and the recovery was uneventful. The patient completely stops taking psychiatric therapy, or any other, with no compliance and has completely social restitution. After the follow-up period, he loses 49 kg, actually BMI = 30. 9 kg/m? and the percentage of excess weight loss (%EWL) is 73.1 %. Conclusion. In psychiatric obese patients, a metabolic procedure should be carefully selected. MGB/OAGB proved to be a successful bariatric procedure in our patient, leading to remission of depression and discontinuation of psychiatric therapy, but also to a significant reduction in body weight in the period of one year after surgery.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68727533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kenan Demirovic, Elma Demirovic, V. Džemidžić, E. Nakaš
Introduction/Objective. Deprogramming of the neuromuscular system with the use of stabilization splint might provide more precise evaluation of the centric relation (CR) - maximum intercuspation (MI) discrepancy. The study aimed to evaluate the differences between the bite registrations obtained in the CR before and after the application of the stabilization splint therapy. Methods. The sample included 48 non-deprogrammed individuals without any apparent signs and symptoms of temporomandibular disorders (TMDs). The neuromuscular system was deprogrammed by employing stabilization splint therapy. A condylar displacement evaluation was performed on vertical, horizontal and transverse planes of space, with the assistance of a condylar position indicator (CPI). Results. The mean values of condylar displacements, which were obtained after the deprogramming of the neuromuscular system, were significantly greater than those obtained before neuromuscular deprogramming for vertical condylar displacement (p < .0001). A greater degree of condylar distraction was observed on the left side of the vertical plane before (p < .01) and after neuromuscular deprogramming (p < .05). The highest level of condylar displacement occurred in the postero-inferior direction subsequent to the muscle deprogramming. Conclusion. It was observed that the level of average condylar displacements was significantly higher following the deprogramming of the neuromuscular system compared to that recorded before neuromuscular deprogramming using stabilization splint therapy. A more precise orthodontic diagnosis could have been obtained if the condyles were placed in a more exact CR position by muscle deprogramming.
{"title":"Assessment of condylar position in asymptomatic individuals before and after neuromuscular deprogramming with a stabilization splint","authors":"Kenan Demirovic, Elma Demirovic, V. Džemidžić, E. Nakaš","doi":"10.2298/sarh220227028d","DOIUrl":"https://doi.org/10.2298/sarh220227028d","url":null,"abstract":"Introduction/Objective. Deprogramming of the neuromuscular system with the use of stabilization splint might provide more precise evaluation of the centric relation (CR) - maximum intercuspation (MI) discrepancy. The study aimed to evaluate the differences between the bite registrations obtained in the CR before and after the application of the stabilization splint therapy. Methods. The sample included 48 non-deprogrammed individuals without any apparent signs and symptoms of temporomandibular disorders (TMDs). The neuromuscular system was deprogrammed by employing stabilization splint therapy. A condylar displacement evaluation was performed on vertical, horizontal and transverse planes of space, with the assistance of a condylar position indicator (CPI). Results. The mean values of condylar displacements, which were obtained after the deprogramming of the neuromuscular system, were significantly greater than those obtained before neuromuscular deprogramming for vertical condylar displacement (p < .0001). A greater degree of condylar distraction was observed on the left side of the vertical plane before (p < .01) and after neuromuscular deprogramming (p < .05). The highest level of condylar displacement occurred in the postero-inferior direction subsequent to the muscle deprogramming. Conclusion. It was observed that the level of average condylar displacements was significantly higher following the deprogramming of the neuromuscular system compared to that recorded before neuromuscular deprogramming using stabilization splint therapy. A more precise orthodontic diagnosis could have been obtained if the condyles were placed in a more exact CR position by muscle deprogramming.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68728249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jovana Bakalovic, L. Stojcev, Bojan Janjic, B. Gačić
Introduction/Objective. The correct choice of local anesthesia should consider the simplest technique to perform, with maximum anesthesia and minimal discomfort for the patient. The objectives of this research were to determine the efficacy of the modified in comparison to the standard Vazirani-Akinosi technique and to compare techniques regarding clinically relevant parameters. Methods. The research was conducted at the Clinic for Oral Surgery, School of Dental Medicine, University of Belgrade. A prospective, randomized, single-blinded clinical trial included sixty patients scheduled for surgical extraction of mandibular third molars. The first group of patients was anesthetized using mVAt, while the second group received anesthesia using VAt. Pain during injection, onset time, duration of anesthesia, and width of the anesthetized area were evaluated parameters. Results. Out of 60 performed injections, 42 were successful, which proved to be statistically significant in comparison to 18 unsuccessful injections (p = 0.047). The failure rate of BN anesthesia was statistically significantly lower in mVAt group (p = 0.030). There was no statistically significant difference among groups considering pain (p = 0.114), onset time (p = 0.370) and duration of anesthesia (p = 0.628). Conclusion. Modified VA technique proved to be more successful regarding BN anesthesia. Considering other examined clinical parameters, both techniques showed similar performance.
{"title":"Evaluation of the success of modified Vazirani-Akinosi technique in comparison to the standard Vazirani-Akinosi technique - a randomized clinical trial","authors":"Jovana Bakalovic, L. Stojcev, Bojan Janjic, B. Gačić","doi":"10.2298/sarh220712030b","DOIUrl":"https://doi.org/10.2298/sarh220712030b","url":null,"abstract":"Introduction/Objective. The correct choice of local anesthesia should consider the simplest technique to perform, with maximum anesthesia and minimal discomfort for the patient. The objectives of this research were to determine the efficacy of the modified in comparison to the standard Vazirani-Akinosi technique and to compare techniques regarding clinically relevant parameters. Methods. The research was conducted at the Clinic for Oral Surgery, School of Dental Medicine, University of Belgrade. A prospective, randomized, single-blinded clinical trial included sixty patients scheduled for surgical extraction of mandibular third molars. The first group of patients was anesthetized using mVAt, while the second group received anesthesia using VAt. Pain during injection, onset time, duration of anesthesia, and width of the anesthetized area were evaluated parameters. Results. Out of 60 performed injections, 42 were successful, which proved to be statistically significant in comparison to 18 unsuccessful injections (p = 0.047). The failure rate of BN anesthesia was statistically significantly lower in mVAt group (p = 0.030). There was no statistically significant difference among groups considering pain (p = 0.114), onset time (p = 0.370) and duration of anesthesia (p = 0.628). Conclusion. Modified VA technique proved to be more successful regarding BN anesthesia. Considering other examined clinical parameters, both techniques showed similar performance.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68729159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Microtia presents a congenital ear deformity ranging from a minor and barely visible defect to a complete absence of the ear. Currently, there are three options for ear reconstruction: autologous costal cartilage, silicon prothesis and prosthetic ear. Ear reconstruction with autologous costal cartilage is usually performed in two stages. During the first stage the cartilaginous framework is fabricated and placed under the skin, in the anatomical position of the ear. In the second stage the elevation of the frame is performed. During these procedures, complications such as vascular compromise of the skin envelope can occur. Cartilage exposure can lead to its resorption and distortion, leading to unsatisfactory anatomical result, and this should be resolved as soon as possible. Cartilage exposure at the convex part of the frame is especially problematic. The goal of this paper is to show that fascial turnover flap is a safe method to deal with cartilage exposure as a complication. Outlines of cases. We present two patients with anotia and hemifacial microsomia. Both underwent autologous cartilage microtia repair. In both patients, the cartilage exposure at the convex part of the ear revealed asa complication. Fascial turnover flap has been used to resolve this complication in both patients. Conclusion. Fascial turnover flap is a safe method to deal with cartilage exposure after microtia reconstruction with autologous cartilage.
{"title":"Fascial turnover flap - an effective method to resolve cartilage exposure after autologous microtia reconstruction","authors":"A. Vlahović, A. Urošević, Mila Živković","doi":"10.2298/sarh220903040v","DOIUrl":"https://doi.org/10.2298/sarh220903040v","url":null,"abstract":"Introduction. Microtia presents a congenital ear deformity ranging from a minor and barely visible defect to a complete absence of the ear. Currently, there are three options for ear reconstruction: autologous costal cartilage, silicon prothesis and prosthetic ear. Ear reconstruction with autologous costal cartilage is usually performed in two stages. During the first stage the cartilaginous framework is fabricated and placed under the skin, in the anatomical position of the ear. In the second stage the elevation of the frame is performed. During these procedures, complications such as vascular compromise of the skin envelope can occur. Cartilage exposure can lead to its resorption and distortion, leading to unsatisfactory anatomical result, and this should be resolved as soon as possible. Cartilage exposure at the convex part of the frame is especially problematic. The goal of this paper is to show that fascial turnover flap is a safe method to deal with cartilage exposure as a complication. Outlines of cases. We present two patients with anotia and hemifacial microsomia. Both underwent autologous cartilage microtia repair. In both patients, the cartilage exposure at the convex part of the ear revealed asa complication. Fascial turnover flap has been used to resolve this complication in both patients. Conclusion. Fascial turnover flap is a safe method to deal with cartilage exposure after microtia reconstruction with autologous cartilage.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68729534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Topuzović, M. Radovanović, Nenad Topuzovic, A. Janicic, Aleksa Zubelić
Introduction. Urinary stasis in transplanted kidney occurs due to ureteral obstruction caused by intrinsic or extrinsic etiological factors. The aim of this study was to determine the prevalence, time of occurrence and etiopathogenetic factors of urinary stasis and their distribution according to the type of kidney donor. And to analyze the success of different types of surgical and conservative treatment. Methods. The retrospective-prospective randomized study included 580 patients transplanted in Transplant Center, Clinic of Urology, Clinical Center of Serbia for a period of 20 years. After diagnosing urinary stasis, minimally invasive or open surgical interventions were performed, while for one group of patients the definitive treatment was non-surgical with observation and active monitoring. The main control parameters during non-surgical treatment were diameter of pyelon, serum creatinine values and urine culture findings. Results. Urinary stasis was found in 15% of transplanted patients. The largest number of transplanted patients had early urinary stasis, within 3 months of transplantation (68%). The most common etiological factors of urinary stasis were intrinsic factors (66%), which were significantly more frequent in transplant patients from a living donor. Non-surgical treatment with observation and active monitoring was successfully performed in 22% of patients. Conclusion. The largest number of transplanted patients with urinary stasis has been successfully treated surgically, most often with open surgery. Surgical correction is advised in cases of pronounced dilatation of the canalicular system with a tendency to increase, in progressive decrease in renal function and recurrent complicated urinary infections refractory to antibiotic therapy.
{"title":"Urinary stasis in transplanted kidney - twenty years of experience of one transplant center","authors":"C. Topuzović, M. Radovanović, Nenad Topuzovic, A. Janicic, Aleksa Zubelić","doi":"10.2298/sarh220929061t","DOIUrl":"https://doi.org/10.2298/sarh220929061t","url":null,"abstract":"Introduction. Urinary stasis in transplanted kidney occurs due to ureteral obstruction caused by intrinsic or extrinsic etiological factors. The aim of this study was to determine the prevalence, time of occurrence and etiopathogenetic factors of urinary stasis and their distribution according to the type of kidney donor. And to analyze the success of different types of surgical and conservative treatment. Methods. The retrospective-prospective randomized study included 580 patients transplanted in Transplant Center, Clinic of Urology, Clinical Center of Serbia for a period of 20 years. After diagnosing urinary stasis, minimally invasive or open surgical interventions were performed, while for one group of patients the definitive treatment was non-surgical with observation and active monitoring. The main control parameters during non-surgical treatment were diameter of pyelon, serum creatinine values and urine culture findings. Results. Urinary stasis was found in 15% of transplanted patients. The largest number of transplanted patients had early urinary stasis, within 3 months of transplantation (68%). The most common etiological factors of urinary stasis were intrinsic factors (66%), which were significantly more frequent in transplant patients from a living donor. Non-surgical treatment with observation and active monitoring was successfully performed in 22% of patients. Conclusion. The largest number of transplanted patients with urinary stasis has been successfully treated surgically, most often with open surgery. Surgical correction is advised in cases of pronounced dilatation of the canalicular system with a tendency to increase, in progressive decrease in renal function and recurrent complicated urinary infections refractory to antibiotic therapy.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68729571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Obradović, S. Vujović, Jana Desnica, Momir Stevanović, Dragana Stanisic, I. Ognjanović, Mirko Mikic, Borivoj Bijelić, Ljiljana Subaric, V. Djordjevic
Introduction/Objective. Bone resorption is a common problem in dentistry, and bone reparation cannot be easily achieved. Several techniques of bone grafting and the use of low-level laser treatment (LLLT) as a new therapeutic optional recommended for improving bone repair were applied. The aim of the study was to investigate the influence of LLLT in bone repair of artificially made bone defects in the rat mandible using histomorphometry. Methods. The research was carried out on 60 female rats. Bone defects were made in the mandible, and animals were divided into two groups, each containing 30 animals. In the study group, the implantation site was submitted to GaAlAs laser irradiation 670nm, 5 mW, 4 min/per day for 5 days. The control group had no postoperative treatment. Animals were sacrificed after two, six, and eight weeks post LLLT, and preparations were analysed by histomorphometry, determining bone area fraction, bone area, integral density, mean density, and density variation. Results. Histomorphometric analysis revealed statistically higher values of area fraction, area, and integral density in the study group after two and six weeks. However, no beneficial laser effect was noticed after eight weeks. Conclusion. Low-level lasers have a stimulating effect on reparatory mechanisms in the early regeneration stage of artificially made bone defects in the rat mandible and can be used as a useful helping method in bone treatment.
{"title":"Low-level laser efficiency in reparation of bone defects","authors":"R. Obradović, S. Vujović, Jana Desnica, Momir Stevanović, Dragana Stanisic, I. Ognjanović, Mirko Mikic, Borivoj Bijelić, Ljiljana Subaric, V. Djordjevic","doi":"10.2298/sarh220922003o","DOIUrl":"https://doi.org/10.2298/sarh220922003o","url":null,"abstract":"Introduction/Objective. Bone resorption is a common problem in dentistry, and bone reparation cannot be easily achieved. Several techniques of bone grafting and the use of low-level laser treatment (LLLT) as a new therapeutic optional recommended for improving bone repair were applied. The aim of the study was to investigate the influence of LLLT in bone repair of artificially made bone defects in the rat mandible using histomorphometry. Methods. The research was carried out on 60 female rats. Bone defects were made in the mandible, and animals were divided into two groups, each containing 30 animals. In the study group, the implantation site was submitted to GaAlAs laser irradiation 670nm, 5 mW, 4 min/per day for 5 days. The control group had no postoperative treatment. Animals were sacrificed after two, six, and eight weeks post LLLT, and preparations were analysed by histomorphometry, determining bone area fraction, bone area, integral density, mean density, and density variation. Results. Histomorphometric analysis revealed statistically higher values of area fraction, area, and integral density in the study group after two and six weeks. However, no beneficial laser effect was noticed after eight weeks. Conclusion. Low-level lasers have a stimulating effect on reparatory mechanisms in the early regeneration stage of artificially made bone defects in the rat mandible and can be used as a useful helping method in bone treatment.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68729777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Milosavljević, B. Tadić, N. Grubor, D. Erić, B. Tošković
Introduction. The most common indications for placing a biliary stent are benign and malignant diseases that interfere with the normal flow of bile through the extrahepatic bile ducts. This procedure carries the risk of developing early and late complications. Case outline. We present the case of a 63-year-old female patient admitted to our hospital for additional diagnostics and treatment. At admission the patient reported the onset of the following symptoms several days prior to hospitalization: severe abdominal pain, predominantly in the upper quadrants, nausea, vomiting, and icterus. Initial idea of carrying out non-surgical treatment of this condition, the patient was referred for endoscopic retrograde cholangiopancreatography for the purpose of endoscopic calculi extraction. However, due to technical difficulties, the aforementioned procedure was not carried out. Instead, upon endoscopic papillotomy, a plastic biliary stent was placed. The second day after the procedure, the patient reported passing dark stools. After that, an esophagogastroduodenoscopy was performed, which revealed a biliary stent in the duodenum, but without active bleeding. As part of the same procedure, the biliary stent was removed, and the next day the patient underwent surgical treatment. Conclusion. In order to prevent and reduce the incidence of adverse effects and complications, special caution should be applied when performing the procedure. It is even more important to timely recognize the occurrence of complications and to treat them promptly, in order to achieve the best treatment outcomes possible.
{"title":"Migration of biliary endoprosthesis - case report and literature review","authors":"V. Milosavljević, B. Tadić, N. Grubor, D. Erić, B. Tošković","doi":"10.2298/sarh221113041m","DOIUrl":"https://doi.org/10.2298/sarh221113041m","url":null,"abstract":"Introduction. The most common indications for placing a biliary stent are benign and malignant diseases that interfere with the normal flow of bile through the extrahepatic bile ducts. This procedure carries the risk of developing early and late complications. Case outline. We present the case of a 63-year-old female patient admitted to our hospital for additional diagnostics and treatment. At admission the patient reported the onset of the following symptoms several days prior to hospitalization: severe abdominal pain, predominantly in the upper quadrants, nausea, vomiting, and icterus. Initial idea of carrying out non-surgical treatment of this condition, the patient was referred for endoscopic retrograde cholangiopancreatography for the purpose of endoscopic calculi extraction. However, due to technical difficulties, the aforementioned procedure was not carried out. Instead, upon endoscopic papillotomy, a plastic biliary stent was placed. The second day after the procedure, the patient reported passing dark stools. After that, an esophagogastroduodenoscopy was performed, which revealed a biliary stent in the duodenum, but without active bleeding. As part of the same procedure, the biliary stent was removed, and the next day the patient underwent surgical treatment. Conclusion. In order to prevent and reduce the incidence of adverse effects and complications, special caution should be applied when performing the procedure. It is even more important to timely recognize the occurrence of complications and to treat them promptly, in order to achieve the best treatment outcomes possible.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68729910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vladimir Radlović, Z. Golubović, Z. Lekovic, S. Dučić, N. Radlović, B. Jovanovic, B. Bukva, P. Pavićević, D. Nikolić, J. Janković
Introduction/Objective. Gilbert syndrome (GS) is the most common hereditary hyperbilirubinemia. As well as mild unconjugated hyperbilirubinemia, it is characterized by the excess of bilirubin monoglucuronide over diglucuronide in the bile and thus increases the risk of biliary calculosis. The aim of the study was to determine the importance of GS as a risk factor in the development of cholelithiasis in children. Methods. The study included a sample of 31 children (14 male and 17 female, mean age 12.16 ? 4.11 years, range 3 to 16.75 years) with symptomatic cholelithiasis The diagnosis of cholelithiasis was based on an ultrasonographic finding and for GS on at least a double increase of unconjugated bilirubin fraction after a three-day hypocaloric diet (400 kcal per day). Results. GS was confirmed in 5 or 16.13% of patients (3 male and 2 female, mean age 14.71 ? 0.55 years, range 14 to 15.3 years). In addition to the GS, in the history of the disease they all had some of the additional risk factors for the development of cholelithiasis. One of them had an identical problem in its mother, one had hereditary elliptocytosis, one ofthem had sudden weight loss, one was overweight and one had premature birth and sepsis. Conclusion. GS registers in one sixth of children with cholelithiasis, but in none of them as the only risk factor for developing this disease. This finding suggests that the GS is a risk factor for the development of cholelithiasis, but not that it is sufficient in that sense.
{"title":"Gilbert syndrome as a risk factor for the development of cholelithiasis in children","authors":"Vladimir Radlović, Z. Golubović, Z. Lekovic, S. Dučić, N. Radlović, B. Jovanovic, B. Bukva, P. Pavićević, D. Nikolić, J. Janković","doi":"10.2298/sarh221206031r","DOIUrl":"https://doi.org/10.2298/sarh221206031r","url":null,"abstract":"Introduction/Objective. Gilbert syndrome (GS) is the most common hereditary hyperbilirubinemia. As well as mild unconjugated hyperbilirubinemia, it is characterized by the excess of bilirubin monoglucuronide over diglucuronide in the bile and thus increases the risk of biliary calculosis. The aim of the study was to determine the importance of GS as a risk factor in the development of cholelithiasis in children. Methods. The study included a sample of 31 children (14 male and 17 female, mean age 12.16 ? 4.11 years, range 3 to 16.75 years) with symptomatic cholelithiasis The diagnosis of cholelithiasis was based on an ultrasonographic finding and for GS on at least a double increase of unconjugated bilirubin fraction after a three-day hypocaloric diet (400 kcal per day). Results. GS was confirmed in 5 or 16.13% of patients (3 male and 2 female, mean age 14.71 ? 0.55 years, range 14 to 15.3 years). In addition to the GS, in the history of the disease they all had some of the additional risk factors for the development of cholelithiasis. One of them had an identical problem in its mother, one had hereditary elliptocytosis, one ofthem had sudden weight loss, one was overweight and one had premature birth and sepsis. Conclusion. GS registers in one sixth of children with cholelithiasis, but in none of them as the only risk factor for developing this disease. This finding suggests that the GS is a risk factor for the development of cholelithiasis, but not that it is sufficient in that sense.","PeriodicalId":22263,"journal":{"name":"Srpski arhiv za celokupno lekarstvo","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68730821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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