Pub Date : 2020-11-01DOI: 10.21608/ebwhj.2020.20279.1058
M. el-Sokkary, B. Islam, Esraa Alshawadfy
Aim: To the best of our knowledge, no previous studies have addressed the association of unexplained infertility with protein S activity. This case-control study was performed to evaluate the prevalence of protein S activity in women with unexplained infertility and to compare its prevalence in normal fertile women. Materials and Methods: This is a case-control study conducted to evaluate the prevalence of protein S activity in women with unexplained infertility conducted at Ain-Shams University Maternity Hospital. A total of 30 women with unexplained primary infertility and another 30 fertile women of matched age group as their control were recruited from September 2018 to March 2019. Using STA Compact Max® Coagulation System protein S was measured. STA-staclot kit supplied by Stago, France is a clotting assay for measuring protein S activity in human citrated plasma. A venous blood sample (3 ml) was collected from every participant at any day of the menstrual cycle then the samples were collected in (3.2%) sodium citrate tubes (venous blood must be mixed with the sodium citrate immediately after collection by turning upside down gently the tube 3 or 4 times), then centrifugation performed as fast as possible less than an hour to obtain platelet-poor plasma and centrifuged at 2500g for 15 min (platelet poor plasma). Samples and test reagents are loaded into the instrument where sample handling, reagent delivery, analysis, and reporting of results are performed automatically. Results: This study failed to find a relationship between protein S activity and unexplained infertility compared to the normal fertile population. Despite finding none in the unexplained infertility sample population with protein S deficiency and one in the control group, this difference failed to reach significance. Conclusion: In conclusion, this study failed to find any association between protein S activity and unexplained infertility but this study showed that the mean of protein S percentage in group 1 (cases) is lower than the mean in group 2 (controls).
{"title":"Protein S activity in women with unexplained infertility","authors":"M. el-Sokkary, B. Islam, Esraa Alshawadfy","doi":"10.21608/ebwhj.2020.20279.1058","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.20279.1058","url":null,"abstract":"Aim: To the best of our knowledge, no previous studies have addressed the association of unexplained infertility with protein S activity. This case-control study was performed to evaluate the prevalence of protein S activity in women with unexplained infertility and to compare its prevalence in normal fertile women. Materials and Methods: This is a case-control study conducted to evaluate the prevalence of protein S activity in women with unexplained infertility conducted at Ain-Shams University Maternity Hospital. A total of 30 women with unexplained primary infertility and another 30 fertile women of matched age group as their control were recruited from September 2018 to March 2019. Using STA Compact Max® Coagulation System protein S was measured. STA-staclot kit supplied by Stago, France is a clotting assay for measuring protein S activity in human citrated plasma. A venous blood sample (3 ml) was collected from every participant at any day of the menstrual cycle then the samples were collected in (3.2%) sodium citrate tubes (venous blood must be mixed with the sodium citrate immediately after collection by turning upside down gently the tube 3 or 4 times), then centrifugation performed as fast as possible less than an hour to obtain platelet-poor plasma and centrifuged at 2500g for 15 min (platelet poor plasma). Samples and test reagents are loaded into the instrument where sample handling, reagent delivery, analysis, and reporting of results are performed automatically. Results: This study failed to find a relationship between protein S activity and unexplained infertility compared to the normal fertile population. Despite finding none in the unexplained infertility sample population with protein S deficiency and one in the control group, this difference failed to reach significance. Conclusion: In conclusion, this study failed to find any association between protein S activity and unexplained infertility but this study showed that the mean of protein S percentage in group 1 (cases) is lower than the mean in group 2 (controls).","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131526310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.21608/ebwhj.2020.36665.1102
Ahmed A Wali, Walaa Abdelfattah, Shimaa M. Abd-el-fatah
Aim: This study aimed to determine the prevalence of thyroid autoimmunity (antithyroglobulin and antithyroid peroxidase)and thyroid dysfunction (hypo- or hyperthyroidism) among women with different causes of infertility.Materials and Methods: A cross-sectional study was carried out among 255 patients with infertility who were recruitedfrom the gynecology clinic, Kasr Al Ainy Hospitals, Cairo University, Egypt. Patients were divided into 4 groups. Group A including infertile women with either unexplained or anovulatory infertility with/without associated male factor,group B including infertile women with a tubal (mechanical) factor of infertility with/without associated male factor,group C including infertile women with both anovulation and tubal factor with/without associated male factor and acontrol group including women with exclusive male factor. Serum levels of TSH, antithyroid peroxidase (anti-TPO) andantithyroglobulin (anti-TG) were measured in all patients.Results: The TSH level was abnormal in 22 out of 255 women (9.8%). 44 (17.3%) were positive for anti-TPOantibodies, 26 (10.2%) were positive for anti-TG antibodies. Seventy patients (27.5%) had TSH levels above 2.5 mIU/L.No significant difference was found between different causes of infertility in TSH or antithyroid antibodies. There was apositive correlation between frequencies of both positive anti-TG and secondary infertility in group B.Conclusion: There is no significant relationship between thyroid dysfunction and the type of infertility (functional ormechanical), or its duration. According to our study, the prevalence of antithyroid antibodies seems to be the same ininfertile women and control. Antithyroglobulin might be associated with secondary infertility due to tubal factor.
目的:本研究旨在确定甲状腺自身免疫(抗甲状腺球蛋白和抗甲状腺过氧化物酶)和甲状腺功能障碍(甲状腺功能减退或甲状腺功能亢进)在不同原因的不孕妇女中的患病率。材料和方法:从埃及开罗大学Kasr Al Ainy医院妇科门诊招募的255例不孕症患者进行了一项横断面研究。患者分为4组。A组包括不明原因或无排卵性不孕症的不孕妇女,伴有/不伴有男性因素;B组包括伴有/不伴有男性因素的输卵管(机械)不孕症的不孕妇女,伴有/不伴有男性因素;C组包括伴有无排卵和输卵管因素的不孕妇女,伴有/不伴有男性因素;对照组包括仅伴有男性因素的妇女。测定所有患者血清TSH、抗甲状腺过氧化物酶(anti-TPO)和抗甲状腺球蛋白(anti-TG)水平。结果:255例女性中TSH异常22例(9.8%)。抗tpo44例(17.3%),抗tg 26例(10.2%)。70例患者(27.5%)TSH水平高于2.5 mIU/L。不同原因不孕的TSH和抗甲状腺抗体无显著差异。b组患者抗tg阳性频率与继发性不孕均呈正相关。结论:甲状腺功能障碍与不孕类型(功能性或机械性)及持续时间无显著关系。根据我们的研究,抗甲状腺抗体的患病率似乎与控制不育的女性相同。抗甲状腺球蛋白可能与输卵管因素引起的继发性不孕有关。
{"title":"Prevalence of thyroid dysfunction and thyroid autoimmunity in infertile women","authors":"Ahmed A Wali, Walaa Abdelfattah, Shimaa M. Abd-el-fatah","doi":"10.21608/ebwhj.2020.36665.1102","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.36665.1102","url":null,"abstract":"Aim: This study aimed to determine the prevalence of thyroid autoimmunity (antithyroglobulin and antithyroid peroxidase)and thyroid dysfunction (hypo- or hyperthyroidism) among women with different causes of infertility.Materials and Methods: A cross-sectional study was carried out among 255 patients with infertility who were recruitedfrom the gynecology clinic, Kasr Al Ainy Hospitals, Cairo University, Egypt. Patients were divided into 4 groups. Group A including infertile women with either unexplained or anovulatory infertility with/without associated male factor,group B including infertile women with a tubal (mechanical) factor of infertility with/without associated male factor,group C including infertile women with both anovulation and tubal factor with/without associated male factor and acontrol group including women with exclusive male factor. Serum levels of TSH, antithyroid peroxidase (anti-TPO) andantithyroglobulin (anti-TG) were measured in all patients.Results: The TSH level was abnormal in 22 out of 255 women (9.8%). 44 (17.3%) were positive for anti-TPOantibodies, 26 (10.2%) were positive for anti-TG antibodies. Seventy patients (27.5%) had TSH levels above 2.5 mIU/L.No significant difference was found between different causes of infertility in TSH or antithyroid antibodies. There was apositive correlation between frequencies of both positive anti-TG and secondary infertility in group B.Conclusion: There is no significant relationship between thyroid dysfunction and the type of infertility (functional ormechanical), or its duration. According to our study, the prevalence of antithyroid antibodies seems to be the same ininfertile women and control. Antithyroglobulin might be associated with secondary infertility due to tubal factor.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"7 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129174838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.21608/ebwhj.2020.43136.1109
H. Ghoniem, M. Abdelnaby
Aim: This study evaluated the role of physical activity in boosting the general health of menopausal women.Materials and Methods: This cross-sectional study was conducted at Suez-Canal University Hospital, Ismailia, Egypt.Hundred-ninety-one menopausal women were included. Their physical activity was assessed using the internationalphysical activity questionnaire (IPAQ), whereas their general heath was evaluated through the 28-item general healthquestionnaire (GHQ). Data were analyzed using SPSS, and results were considered statistically significant at a p-valueless than 0.05.Results: The majority of the enrolled women had a low-to-intermediate level of physical activity, whereas the rest (24%)encountered a high physical level. We found a statistically significant difference in general health subscales between thelow, intermediate and high physical levels (p < 0.001). In particular, women with low physical activity had higher totalGHQ scores compared to those with high physical activity had the lowest total GHQ scores. Moreover, women who wereobese (p < 0.001), diabetic (p < 0.001) and/or hypertensive (p < 0.001), complaining of vaginal dryness (p=0.02) and/orjoint and muscular discomfort (p < 0.001) had significantly higher total GHQ scores.Conclusion: Physical activity of menopausal women is significantly associated with their general health, as less activewomen had poor general health.
{"title":"Impact of Physical Activity on General Health among Menopausal Women","authors":"H. Ghoniem, M. Abdelnaby","doi":"10.21608/ebwhj.2020.43136.1109","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.43136.1109","url":null,"abstract":"Aim: This study evaluated the role of physical activity in boosting the general health of menopausal women.Materials and Methods: This cross-sectional study was conducted at Suez-Canal University Hospital, Ismailia, Egypt.Hundred-ninety-one menopausal women were included. Their physical activity was assessed using the internationalphysical activity questionnaire (IPAQ), whereas their general heath was evaluated through the 28-item general healthquestionnaire (GHQ). Data were analyzed using SPSS, and results were considered statistically significant at a p-valueless than 0.05.Results: The majority of the enrolled women had a low-to-intermediate level of physical activity, whereas the rest (24%)encountered a high physical level. We found a statistically significant difference in general health subscales between thelow, intermediate and high physical levels (p < 0.001). In particular, women with low physical activity had higher totalGHQ scores compared to those with high physical activity had the lowest total GHQ scores. Moreover, women who wereobese (p < 0.001), diabetic (p < 0.001) and/or hypertensive (p < 0.001), complaining of vaginal dryness (p=0.02) and/orjoint and muscular discomfort (p < 0.001) had significantly higher total GHQ scores.Conclusion: Physical activity of menopausal women is significantly associated with their general health, as less activewomen had poor general health.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124793806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.21608/ebwhj.2020.20645.1064
N. Rabei, M. Taha, M. Etman, O. Naser
Background: The terms post-term, prolonged, postdates and post mature are often loosely used interchangeably to signifypregnancies that have exceeded a duration considered to be the upper limit of normal.Objective: The aim of this work was to study the role of Doppler velocimetry of the umbilical and middle cerebral arteriesrepresented by the cerebroplacental ratio and amniotic fluid volume in the prediction of adverse fetal outcome in post-termpregnancies.Materials and Methods: This is a prospective case control study conducted at Ain-Shams University Teaching Hospitalfor Obstetrics and Gynecology, Egypt. The study included 50 pregnant patients who were divided into two groups; group1included 25 pregnant ladies with gestational age of 41 weeks attending the casuality department in labour or in prodromaof labor. while, group 2 included 25 pregnant ladies with gestational age of 41 weeks not in labor and reaching thehospital for ANC, who were selected for termination based on the biophysical profile and poor Doppler indices or CTGchanges. All patients were submitted to antenatal fetal surveillance tests including modified biophysical profile (MBPP)which consists of the non-stress test (NST), amniotic fluid index (AFI), and color Doppler velocimetry of fetoplacentaland fetal vessels including MCA PI, UA PI, and CPR. The accuracy of cerebroplacental ratios (the middle cerebral arteryPI divided by the umbilical artery PI) and amniotic fluid volume as a means of predicting intrauterine fetal distress andadverse perinatal outcome in post-term pregnancies.Results: Cerebroplacental ratio showed the highest sensitivity (95%) in comparison with other parameters, so it is a goodtest to reassure the obstetricians of the fetal well being. Prominent changes in AFI (i.e. 5.0 cm. Asignificant association with FHR decelerations and presence of meconium is proved to exist when AFI is <5.0 cm.Conclusion: The addition of cerebral/umbilical ratios to antenatal surveillance protocols is expected to improve the perinataloutcome. It should be tried in the various high risk pregnancies whenever uteroplacental insufficiency is suspected.
{"title":"Measurement of Cerebro-Placental Doppler Ratio and Amniotic Fluid Index as a Predictor of Perinatal Outcome in Prolonged Pregnancy","authors":"N. Rabei, M. Taha, M. Etman, O. Naser","doi":"10.21608/ebwhj.2020.20645.1064","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.20645.1064","url":null,"abstract":"Background: The terms post-term, prolonged, postdates and post mature are often loosely used interchangeably to signifypregnancies that have exceeded a duration considered to be the upper limit of normal.Objective: The aim of this work was to study the role of Doppler velocimetry of the umbilical and middle cerebral arteriesrepresented by the cerebroplacental ratio and amniotic fluid volume in the prediction of adverse fetal outcome in post-termpregnancies.Materials and Methods: This is a prospective case control study conducted at Ain-Shams University Teaching Hospitalfor Obstetrics and Gynecology, Egypt. The study included 50 pregnant patients who were divided into two groups; group1included 25 pregnant ladies with gestational age of 41 weeks attending the casuality department in labour or in prodromaof labor. while, group 2 included 25 pregnant ladies with gestational age of 41 weeks not in labor and reaching thehospital for ANC, who were selected for termination based on the biophysical profile and poor Doppler indices or CTGchanges. All patients were submitted to antenatal fetal surveillance tests including modified biophysical profile (MBPP)which consists of the non-stress test (NST), amniotic fluid index (AFI), and color Doppler velocimetry of fetoplacentaland fetal vessels including MCA PI, UA PI, and CPR. The accuracy of cerebroplacental ratios (the middle cerebral arteryPI divided by the umbilical artery PI) and amniotic fluid volume as a means of predicting intrauterine fetal distress andadverse perinatal outcome in post-term pregnancies.Results: Cerebroplacental ratio showed the highest sensitivity (95%) in comparison with other parameters, so it is a goodtest to reassure the obstetricians of the fetal well being. Prominent changes in AFI (i.e. 5.0 cm. Asignificant association with FHR decelerations and presence of meconium is proved to exist when AFI is <5.0 cm.Conclusion: The addition of cerebral/umbilical ratios to antenatal surveillance protocols is expected to improve the perinataloutcome. It should be tried in the various high risk pregnancies whenever uteroplacental insufficiency is suspected.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128693664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.21608/EBWHJ.2019.19794.1056
M. Ibrahem, Magdy M. Ibrahim, A. Al-Karamany, R. Etewa
Aim: The aim of this study was to evaluate the possible association between ACE I/D, AT1 receptor 1166 A:C, AT2receptor-1332 A:G, and MMP-9-1562 C:T polymorphisms and risk of preeclampsia in Egyptian women.Materials and Methods: This case-control study included 108 pregnant women was allocated into two groups, 54pre-eclamptic women group and control group which included 54 normotensive pregnant women. Genotyping of AT1 1166A:C and AT2 −1332 A: G were performed by duplex polymerase chain reaction-restriction fragment length polymorphismPCR-RFLP. Genotyping of I/D polymorphism of ACE was carried out by PCR and genotyping of MMP-9 −1562C/T wasperformed by tetra-primer amplification refractory mutation system T- ARMS–PCR.Results: The DD genotype of ACE gene was significantly associated with increased risk of preeclampsia[OR (95% CI) = 2.47 (0.72–8.5), p = 0.02] and the D allele was significantly associated with an increased risk ofpreeclampsia [OR (95% CI) = 1.95 (1.08–3.54), p = 0.02]. The AT2 GG genotype frequency was significantly higher inpreeclampsia [OR (95% CI) = 3.24 (1.25–8.41), p = 0.002] and the G allele [OR (95% CI) = 2.41 (1.39–4.18), p = 0.002]. However, the AT1 CC and MMP9 TT genotypes frequency were insignificantly associated with preeclampsia.Conclusion: ACE gene I/D and -1332A/G of AT2 receptor polymorphisms, but not AT1 receptor gene A1166C andMMP-9 (-1562 C/T) polymorphisms, could be related to the risk of preeclampsia in Egyptian women.
{"title":"Gene polymorphisms and risk of preeclampsia in Egyptian women","authors":"M. Ibrahem, Magdy M. Ibrahim, A. Al-Karamany, R. Etewa","doi":"10.21608/EBWHJ.2019.19794.1056","DOIUrl":"https://doi.org/10.21608/EBWHJ.2019.19794.1056","url":null,"abstract":"Aim: The aim of this study was to evaluate the possible association between ACE I/D, AT1 receptor 1166 A:C, AT2receptor-1332 A:G, and MMP-9-1562 C:T polymorphisms and risk of preeclampsia in Egyptian women.Materials and Methods: This case-control study included 108 pregnant women was allocated into two groups, 54pre-eclamptic women group and control group which included 54 normotensive pregnant women. Genotyping of AT1 1166A:C and AT2 −1332 A: G were performed by duplex polymerase chain reaction-restriction fragment length polymorphismPCR-RFLP. Genotyping of I/D polymorphism of ACE was carried out by PCR and genotyping of MMP-9 −1562C/T wasperformed by tetra-primer amplification refractory mutation system T- ARMS–PCR.Results: The DD genotype of ACE gene was significantly associated with increased risk of preeclampsia[OR (95% CI) = 2.47 (0.72–8.5), p = 0.02] and the D allele was significantly associated with an increased risk ofpreeclampsia [OR (95% CI) = 1.95 (1.08–3.54), p = 0.02]. The AT2 GG genotype frequency was significantly higher inpreeclampsia [OR (95% CI) = 3.24 (1.25–8.41), p = 0.002] and the G allele [OR (95% CI) = 2.41 (1.39–4.18), p = 0.002]. However, the AT1 CC and MMP9 TT genotypes frequency were insignificantly associated with preeclampsia.Conclusion: ACE gene I/D and -1332A/G of AT2 receptor polymorphisms, but not AT1 receptor gene A1166C andMMP-9 (-1562 C/T) polymorphisms, could be related to the risk of preeclampsia in Egyptian women.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131060232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.21608/ebwhj.2020.21883.1069
M. El-Ghannam, H. T. Khairy, M. Mohammad, Mohammed Saeed El Din El Safty, Amira Abozeid
Background: When diagnosing premature rupture membranes is query, choosing the appropriate management needsadditional confirmatory test. Based on their metabolomics, some biochemical markers have been proposed as diagnosticaids. A perfect test could be composed of combining more than one marker. Combining markers is not arbitrary as somecombinations could inversely impact the diagnostic accuracy of the test.Aim: Improving sensitivity and specificity of diagnosis of preterm premature rupture of membranes by combining quantitativeinsulin like growth factor binding protein 1 (IGFBP-1) with quantitative βHCG and/or quantitative prolactin in cervicovaginalfluid.Materials and Methods: It is a cross sectional study. IGFBP-1, prolactin and β-HCG concentrations in vaginal fluid wereexamined in 180 patients with sure membrane state and the diagnostic accuracy of each marker and each combination wasdetermined. The study was conducted between January 2018 and September 2018 in Ain-Shams University MaternityHospital after the approval of the institutional ethics committee. Informed consent has been obtained from the patientsbefore participation.Results: The sensitivity, specificity, PPV, and NPV of Prolactin with cutoff point 11 μIU/ml are 84.4, 73.2, 73.8,and 79.5, respectively, gives accuracy percentage 75.4%. The sensitivity, specificity, PPV, and NPV of ILGFBP-1 withcutoff point 102 μIU/ml are 88.3, 93.5, 100, and 69.4 respectively gives accuracy percentage 81.5%. The sensitivity,specificity, PPV, and NPV of Β-HCG with cutoff point 104 mIU/mL are 85.1, 83.9, 96.2, and 72.8 respectively givesaccuracy percentage 79.9%. The sensitivity, specificity, PPV, and NPV of the combination of IGFBP-1 and β-HCGare 78.4, 100, 100 and 64 respectively gives accuracy percentage 89.7. The sensitivity, specificity, PPV, and NPV of thecombination of IGFBP-1 and prolactin are 78.4, 100, 100 and 68.7, respectively, gives accuracy percentage 84.2. Thesensitivity, specificity, PPV, and NPV of the combination of β-HCG and prolactin are 79.8, 100, 100 and 63.6 respectivelygives accuracy percentage 77.2.Conclusion:Combining IGFBP-1 and β-HCG is the best diagnostic combination to detect amniotic fluid presence invaginal fluid. Combined IGFBP-1 and prolactin offered very little improvement compared to IGFBP-1 alone. Addingprolactin to β-HCG decreased accuracy than each of the other two markers alone.
{"title":"Using β hCG, prolactin and IGFBP I single or in Pairs to diagnose PROM","authors":"M. El-Ghannam, H. T. Khairy, M. Mohammad, Mohammed Saeed El Din El Safty, Amira Abozeid","doi":"10.21608/ebwhj.2020.21883.1069","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.21883.1069","url":null,"abstract":"Background: When diagnosing premature rupture membranes is query, choosing the appropriate management needsadditional confirmatory test. Based on their metabolomics, some biochemical markers have been proposed as diagnosticaids. A perfect test could be composed of combining more than one marker. Combining markers is not arbitrary as somecombinations could inversely impact the diagnostic accuracy of the test.Aim: Improving sensitivity and specificity of diagnosis of preterm premature rupture of membranes by combining quantitativeinsulin like growth factor binding protein 1 (IGFBP-1) with quantitative βHCG and/or quantitative prolactin in cervicovaginalfluid.Materials and Methods: It is a cross sectional study. IGFBP-1, prolactin and β-HCG concentrations in vaginal fluid wereexamined in 180 patients with sure membrane state and the diagnostic accuracy of each marker and each combination wasdetermined. The study was conducted between January 2018 and September 2018 in Ain-Shams University MaternityHospital after the approval of the institutional ethics committee. Informed consent has been obtained from the patientsbefore participation.Results: The sensitivity, specificity, PPV, and NPV of Prolactin with cutoff point 11 μIU/ml are 84.4, 73.2, 73.8,and 79.5, respectively, gives accuracy percentage 75.4%. The sensitivity, specificity, PPV, and NPV of ILGFBP-1 withcutoff point 102 μIU/ml are 88.3, 93.5, 100, and 69.4 respectively gives accuracy percentage 81.5%. The sensitivity,specificity, PPV, and NPV of Β-HCG with cutoff point 104 mIU/mL are 85.1, 83.9, 96.2, and 72.8 respectively givesaccuracy percentage 79.9%. The sensitivity, specificity, PPV, and NPV of the combination of IGFBP-1 and β-HCGare 78.4, 100, 100 and 64 respectively gives accuracy percentage 89.7. The sensitivity, specificity, PPV, and NPV of thecombination of IGFBP-1 and prolactin are 78.4, 100, 100 and 68.7, respectively, gives accuracy percentage 84.2. Thesensitivity, specificity, PPV, and NPV of the combination of β-HCG and prolactin are 79.8, 100, 100 and 63.6 respectivelygives accuracy percentage 77.2.Conclusion:Combining IGFBP-1 and β-HCG is the best diagnostic combination to detect amniotic fluid presence invaginal fluid. Combined IGFBP-1 and prolactin offered very little improvement compared to IGFBP-1 alone. Addingprolactin to β-HCG decreased accuracy than each of the other two markers alone.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129292528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.21608/ebwhj.2019.19210.1053
A. S. El-Houssieny, M. E. Mohamed, H. Allam, D. Atef
Background: Uterine fibroids are the most common female pelvic tumors occurring in about 15% to 30% of women in thereproductive age. When fibroids are associated with symptoms surgical intervention is often indicated.Aim: The aim of the study is to evaluate the efficacy of administration of carbetocin in comparison to vaginal misoprostol in decreasing blood loss in women undergoing abdominal myomectomy. Materials and Methods: The present study is a randomized controlled study carried out in Ain-Shams University Maternity Hospitals. The study included 44 women with age ranged from 25 to 40 years old, subjects were distributed randomly into two equal groups; group 1 included 22 patients who will receive 400 ug misoprostol vaginally, one hour preoperative. Group 2 included 22 patients who will receive bolus of 100 ug carbetocin slowly intravenously once starting anesthesia. Results: Laboratory investigations in this study revealed that there was no statistical significant difference between study groups as regards age, BMI and Parity, Preoperative hemoglobin and HCT (P >0.05). As regards postoperative investigations of Hb and HCT highly statistical significant difference between study groups was found between both groups (P 0.05). Conclusion: These results showed no statistical difference was found between misoprostol and cabetocin groups in estimated blood loss, calculated estimated blood loss, need for blood transfusion and hospital stay.
{"title":"Vaginal misoprostol versus carbetocin in decreasing blood loss in abdominal momectomy : Randomized controlled trial","authors":"A. S. El-Houssieny, M. E. Mohamed, H. Allam, D. Atef","doi":"10.21608/ebwhj.2019.19210.1053","DOIUrl":"https://doi.org/10.21608/ebwhj.2019.19210.1053","url":null,"abstract":"Background: Uterine fibroids are the most common female pelvic tumors occurring in about 15% to 30% of women in thereproductive age. When fibroids are associated with symptoms surgical intervention is often indicated.Aim: The aim of the study is to evaluate the efficacy of administration of carbetocin in comparison to vaginal misoprostol in decreasing blood loss in women undergoing abdominal myomectomy. Materials and Methods: The present study is a randomized controlled study carried out in Ain-Shams University Maternity Hospitals. The study included 44 women with age ranged from 25 to 40 years old, subjects were distributed randomly into two equal groups; group 1 included 22 patients who will receive 400 ug misoprostol vaginally, one hour preoperative. Group 2 included 22 patients who will receive bolus of 100 ug carbetocin slowly intravenously once starting anesthesia. Results: Laboratory investigations in this study revealed that there was no statistical significant difference between study groups as regards age, BMI and Parity, Preoperative hemoglobin and HCT (P >0.05). As regards postoperative investigations of Hb and HCT highly statistical significant difference between study groups was found between both groups (P 0.05). Conclusion: These results showed no statistical difference was found between misoprostol and cabetocin groups in estimated blood loss, calculated estimated blood loss, need for blood transfusion and hospital stay.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114495829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.21608/ebwhj.2020.26278.1085
Amr Riad Yasser, Yasser Abou-Talib, Rania Ragab, M. Nawara
Background: First trimester surgical abortion is a common obstetric procedure with some known complications.Objective: The aim of this study was to examine the incidence of major complications of first trimester surgical abortion in Ain-Shams Maternity Hospital.Patients and Methods: Retrospective record-based case series in which records of patients who underwent first trimester surgical abortion in the period from January 1st, 2016 till December 31st, 2017 were examined.Results: A total of 1003 patients underwent first trimester surgical abortion. The overall major complication rate was 18.2%. There was a higher incidence of one or major complications in patients with previous abortions (P-value <0.002), valve replacement (P- value 0.001), missed and septic abortions, those requiring cervical dilatation, less hemoglobin, higher total leucocytic count, higher PTT.Conclusion: First trimester surgical abortion is a relatively safe procedure with hemorrhage being the most common complication.
{"title":"Complications Associated with First-trimester Surgical Abortion at Ain-Shams Maternity Hospital over the period from January 1, 2016 to December 31, 2017","authors":"Amr Riad Yasser, Yasser Abou-Talib, Rania Ragab, M. Nawara","doi":"10.21608/ebwhj.2020.26278.1085","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.26278.1085","url":null,"abstract":"Background: First trimester surgical abortion is a common obstetric procedure with some known complications.Objective: The aim of this study was to examine the incidence of major complications of first trimester surgical abortion in Ain-Shams Maternity Hospital.Patients and Methods: Retrospective record-based case series in which records of patients who underwent first trimester surgical abortion in the period from January 1st, 2016 till December 31st, 2017 were examined.Results: A total of 1003 patients underwent first trimester surgical abortion. The overall major complication rate was 18.2%. There was a higher incidence of one or major complications in patients with previous abortions (P-value <0.002), valve replacement (P- value 0.001), missed and septic abortions, those requiring cervical dilatation, less hemoglobin, higher total leucocytic count, higher PTT.Conclusion: First trimester surgical abortion is a relatively safe procedure with hemorrhage being the most common complication.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131477079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.21608/ebwhj.2019.17496.1026
Ahmed Abdel-Monem Abo El-Roose, N. Al-Imam, A. M. El-Deib, G. Tawfik
contribute to these changes. These factors could contribute to thyroid dysfunction during pregnancy especially when adeficiency of iodine intake exists and when thyroid reserve is not sufficient.Aim: To study thyroid functions in pregnant women avoiding maternal and fetal complications associated with thyroiddysfunctions.Materials and Methods: A cross-sectional study was carried out on 100 pregnant women attending Obstetrics OutpatientClinic in Suez-Canal University Hospitals were invited to enroll in the study. At the end of study, the blood samples wereassessed for free T3, free T4 and TSH.Results: This study revealed that most of the pregnant women had normal thyroid functions (51%), while subclinicalhypothyroidism (39%) was the most prevalent disorder followed by clinical hypothyroidism (6%) and isolatedhypothyroxinemia (4%).Conclusion: The most prevalent pattern of thyroid dysfunction in pregnant women was subclinical hypothyroidism.
{"title":"Assessment of Thyroid Function in Pregnant Females Attending Suez Canal University Hospital","authors":"Ahmed Abdel-Monem Abo El-Roose, N. Al-Imam, A. M. El-Deib, G. Tawfik","doi":"10.21608/ebwhj.2019.17496.1026","DOIUrl":"https://doi.org/10.21608/ebwhj.2019.17496.1026","url":null,"abstract":"contribute to these changes. These factors could contribute to thyroid dysfunction during pregnancy especially when adeficiency of iodine intake exists and when thyroid reserve is not sufficient.Aim: To study thyroid functions in pregnant women avoiding maternal and fetal complications associated with thyroiddysfunctions.Materials and Methods: A cross-sectional study was carried out on 100 pregnant women attending Obstetrics OutpatientClinic in Suez-Canal University Hospitals were invited to enroll in the study. At the end of study, the blood samples wereassessed for free T3, free T4 and TSH.Results: This study revealed that most of the pregnant women had normal thyroid functions (51%), while subclinicalhypothyroidism (39%) was the most prevalent disorder followed by clinical hypothyroidism (6%) and isolatedhypothyroxinemia (4%).Conclusion: The most prevalent pattern of thyroid dysfunction in pregnant women was subclinical hypothyroidism.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133547801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-01DOI: 10.21608/ebwhj.2020.20626.1062
A. Ibrahim, Mohamed Mohamed El-Mandooh, Haitham Fathy Mohammed Gad, H. Hariri
Background: Infertility is defined by the World Health Organisation (WHO) as a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse and is estimated to affect as many as 48.5 million couples worldwide. Unexplained infertility (UI) constitutes an important portion of the infertility reasons (up to 30%) and is diagnosed when the causes of male or female infertility remains unknown.Aim: The aim of the study was to compare ovarian, uterine artery and subendometrial vessels resistance by measuring PI and RI of patients diagnosed as UI undergoing ICSI in the day of embryo transfer and control group diagnosed as fertile by having at least one livebirth in peri-implantation period from day 19 to day 21.Materials and Methods:The current study is a prospective case control study, which was conducted at the Assisted Reproduction Technology unit of Ain Shams University Maternity Hospital during the period from September 2017 to July 2019. The current study included two groups of patients one group is unexplained infertility attending the Assisted Reproduction Unit and the other is control fertile group each group consists of 51 women.Results: There was statistically significant difference between the unexplained infertility group and control fertile group as regard Uterine and subendometrial artery PI, RI and ovarian artery RI in which resistance indexes was significantly higher in the UI group than control group. The cut off values of PI, RI between unexplained infertility and fertile group are ≥1.88, ≥0.8 for Uterine artery, and ≥ 0.87, ≥0.53 for subendometrial arteries, and ≥ 0.59 for ovarian artery RI. Among the unexplained infertility undergoing ICSI patients the pregnancy rate is 23.5%. There was no statistically significant difference between the two groups (pregnant group and non-pregnant group) as regard the age, BMI, duration of infertility or the basal hormonal profile.Conclusion: Doppler parameters are useful tools to assess endometrial receptivity in unexplained infertility patients undergoing ICSI. This study found that Uterine, Ovarian, subendometrial arteries plasticity index (PI) and resistance index RI measured on the day of embryo transfer higher than fertile women and have value in judging endometrial receptivity and predict the final outcome of IVF/ ICSI- ET. Uterine, ovarian and subendometrial blood flow assessed by measuring PI, RI of these arteries was impaired in unexplained infertility patients compared to fertile women. Also, uterine arteries PI, ovarian and subendometrial arteries PI, RI differ in pregnancy outcome in unexplained infertility patients undergoing ICSI.
{"title":"Ovarian and Uterine Blood Flow Indices in Patients with Unexplained Infertility Undergoing ICSI and their Relation to Clinical Pregnancy Rate","authors":"A. Ibrahim, Mohamed Mohamed El-Mandooh, Haitham Fathy Mohammed Gad, H. Hariri","doi":"10.21608/ebwhj.2020.20626.1062","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.20626.1062","url":null,"abstract":"Background: Infertility is defined by the World Health Organisation (WHO) as a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse and is estimated to affect as many as 48.5 million couples worldwide. Unexplained infertility (UI) constitutes an important portion of the infertility reasons (up to 30%) and is diagnosed when the causes of male or female infertility remains unknown.Aim: The aim of the study was to compare ovarian, uterine artery and subendometrial vessels resistance by measuring PI and RI of patients diagnosed as UI undergoing ICSI in the day of embryo transfer and control group diagnosed as fertile by having at least one livebirth in peri-implantation period from day 19 to day 21.Materials and Methods:The current study is a prospective case control study, which was conducted at the Assisted Reproduction Technology unit of Ain Shams University Maternity Hospital during the period from September 2017 to July 2019. The current study included two groups of patients one group is unexplained infertility attending the Assisted Reproduction Unit and the other is control fertile group each group consists of 51 women.Results: There was statistically significant difference between the unexplained infertility group and control fertile group as regard Uterine and subendometrial artery PI, RI and ovarian artery RI in which resistance indexes was significantly higher in the UI group than control group. The cut off values of PI, RI between unexplained infertility and fertile group are ≥1.88, ≥0.8 for Uterine artery, and ≥ 0.87, ≥0.53 for subendometrial arteries, and ≥ 0.59 for ovarian artery RI. Among the unexplained infertility undergoing ICSI patients the pregnancy rate is 23.5%. There was no statistically significant difference between the two groups (pregnant group and non-pregnant group) as regard the age, BMI, duration of infertility or the basal hormonal profile.Conclusion: Doppler parameters are useful tools to assess endometrial receptivity in unexplained infertility patients undergoing ICSI. This study found that Uterine, Ovarian, subendometrial arteries plasticity index (PI) and resistance index RI measured on the day of embryo transfer higher than fertile women and have value in judging endometrial receptivity and predict the final outcome of IVF/ ICSI- ET. Uterine, ovarian and subendometrial blood flow assessed by measuring PI, RI of these arteries was impaired in unexplained infertility patients compared to fertile women. Also, uterine arteries PI, ovarian and subendometrial arteries PI, RI differ in pregnancy outcome in unexplained infertility patients undergoing ICSI.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127461175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}