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Protein S activity in women with unexplained infertility 不明原因不孕妇女的蛋白S活性
Pub Date : 2020-11-01 DOI: 10.21608/ebwhj.2020.20279.1058
M. el-Sokkary, B. Islam, Esraa Alshawadfy
Aim: To the best of our knowledge, no previous studies have addressed the association of unexplained infertility with protein S activity. This case-control study was performed to evaluate the prevalence of protein S activity in women with unexplained infertility and to compare its prevalence in normal fertile women. Materials and Methods: This is a case-control study conducted to evaluate the prevalence of protein S activity in women with unexplained infertility conducted at Ain-Shams University Maternity Hospital. A total of 30 women with unexplained primary infertility and another 30 fertile women of matched age group as their control were recruited from September 2018 to March 2019. Using STA Compact Max® Coagulation System protein S was measured. STA-staclot kit supplied by Stago, France is a clotting assay for measuring protein S activity in human citrated plasma. A venous blood sample (3 ml) was collected from every participant at any day of the menstrual cycle then the samples were collected in (3.2%) sodium citrate tubes (venous blood must be mixed with the sodium citrate immediately after collection by turning upside down gently the tube 3 or 4 times), then centrifugation performed as fast as possible less than an hour to obtain platelet-poor plasma and centrifuged at 2500g for 15 min (platelet poor plasma). Samples and test reagents are loaded into the instrument where sample handling, reagent delivery, analysis, and reporting of results are performed automatically. Results: This study failed to find a relationship between protein S activity and unexplained infertility compared to the normal fertile population. Despite finding none in the unexplained infertility sample population with protein S deficiency and one in the control group, this difference failed to reach significance. Conclusion: In conclusion, this study failed to find any association between protein S activity and unexplained infertility but this study showed that the mean of protein S percentage in group 1 (cases) is lower than the mean in group 2 (controls).
目的:据我们所知,以前没有研究解决不明原因不孕与蛋白S活性的关系。本病例对照研究旨在评估不明原因不孕症妇女中蛋白S活性的流行程度,并比较其在正常生育妇女中的流行程度。材料和方法:这是一项病例对照研究,旨在评估在Ain-Shams大学妇产医院进行的不明原因不孕症妇女中蛋白S活性的患病率。2018年9月至2019年3月,共招募了30名不明原因原发性不孕症女性和另外30名匹配年龄组的有生育能力女性作为对照组。使用STA Compact Max®凝血系统测定蛋白S。STA-staclot试剂盒由法国Stago公司提供,是一种用于测定人柠檬酸血浆中蛋白S活性的凝血检测试剂盒。在月经周期的任意一天从每位受试者身上采集静脉血(3ml),然后将样本采集在(3.2%)柠檬酸钠管中(静脉血采集后必须立即与柠檬酸钠混合,轻轻倒转管3或4次),然后尽可能快地离心不到1小时以获得无血小板血浆,并在2500g下离心15分钟(无血小板血浆)。样品和测试试剂装载到仪器中,其中样品处理,试剂交付,分析和报告结果自动执行。结果:与正常生育人群相比,本研究未能发现蛋白S活性与不明原因不孕症之间的关系。尽管在不明原因不育的蛋白S缺乏症样本人群中未发现一例,而在对照组中发现一例,但这种差异没有达到显著性。结论:本研究未发现蛋白S活性与不明原因不孕症之间的关联,但本研究显示1组(病例)蛋白S百分比的平均值低于2组(对照组)的平均值。
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引用次数: 0
Prevalence of thyroid dysfunction and thyroid autoimmunity in infertile women 不孕妇女甲状腺功能障碍和甲状腺自身免疫的患病率
Pub Date : 2020-11-01 DOI: 10.21608/ebwhj.2020.36665.1102
Ahmed A Wali, Walaa Abdelfattah, Shimaa M. Abd-el-fatah
Aim: This study aimed to determine the prevalence of thyroid autoimmunity (antithyroglobulin and antithyroid peroxidase)and thyroid dysfunction (hypo- or hyperthyroidism) among women with different causes of infertility.Materials and Methods: A cross-sectional study was carried out among 255 patients with infertility who were recruitedfrom the gynecology clinic, Kasr Al Ainy Hospitals, Cairo University, Egypt. Patients were divided into 4 groups. Group A including infertile women with either unexplained or anovulatory infertility with/without associated male factor,group B including infertile women with a tubal (mechanical) factor of infertility with/without associated male factor,group C including infertile women with both anovulation and tubal factor with/without associated male factor and acontrol group including women with exclusive male factor. Serum levels of TSH, antithyroid peroxidase (anti-TPO) andantithyroglobulin (anti-TG) were measured in all patients.Results: The TSH level was abnormal in 22 out of 255 women (9.8%). 44 (17.3%) were positive for anti-TPOantibodies, 26 (10.2%) were positive for anti-TG antibodies. Seventy patients (27.5%) had TSH levels above 2.5 mIU/L.No significant difference was found between different causes of infertility in TSH or antithyroid antibodies. There was apositive correlation between frequencies of both positive anti-TG and secondary infertility in group B.Conclusion: There is no significant relationship between thyroid dysfunction and the type of infertility (functional ormechanical), or its duration. According to our study, the prevalence of antithyroid antibodies seems to be the same ininfertile women and control. Antithyroglobulin might be associated with secondary infertility due to tubal factor.
目的:本研究旨在确定甲状腺自身免疫(抗甲状腺球蛋白和抗甲状腺过氧化物酶)和甲状腺功能障碍(甲状腺功能减退或甲状腺功能亢进)在不同原因的不孕妇女中的患病率。材料和方法:从埃及开罗大学Kasr Al Ainy医院妇科门诊招募的255例不孕症患者进行了一项横断面研究。患者分为4组。A组包括不明原因或无排卵性不孕症的不孕妇女,伴有/不伴有男性因素;B组包括伴有/不伴有男性因素的输卵管(机械)不孕症的不孕妇女,伴有/不伴有男性因素;C组包括伴有无排卵和输卵管因素的不孕妇女,伴有/不伴有男性因素;对照组包括仅伴有男性因素的妇女。测定所有患者血清TSH、抗甲状腺过氧化物酶(anti-TPO)和抗甲状腺球蛋白(anti-TG)水平。结果:255例女性中TSH异常22例(9.8%)。抗tpo44例(17.3%),抗tg 26例(10.2%)。70例患者(27.5%)TSH水平高于2.5 mIU/L。不同原因不孕的TSH和抗甲状腺抗体无显著差异。b组患者抗tg阳性频率与继发性不孕均呈正相关。结论:甲状腺功能障碍与不孕类型(功能性或机械性)及持续时间无显著关系。根据我们的研究,抗甲状腺抗体的患病率似乎与控制不育的女性相同。抗甲状腺球蛋白可能与输卵管因素引起的继发性不孕有关。
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引用次数: 1
Impact of Physical Activity on General Health among Menopausal Women 体育活动对绝经期妇女总体健康的影响
Pub Date : 2020-11-01 DOI: 10.21608/ebwhj.2020.43136.1109
H. Ghoniem, M. Abdelnaby
Aim: This study evaluated the role of physical activity in boosting the general health of menopausal women.Materials and Methods: This cross-sectional study was conducted at Suez-Canal University Hospital, Ismailia, Egypt.Hundred-ninety-one menopausal women were included. Their physical activity was assessed using the internationalphysical activity questionnaire (IPAQ), whereas their general heath was evaluated through the 28-item general healthquestionnaire (GHQ). Data were analyzed using SPSS, and results were considered statistically significant at a p-valueless than 0.05.Results: The majority of the enrolled women had a low-to-intermediate level of physical activity, whereas the rest (24%)encountered a high physical level. We found a statistically significant difference in general health subscales between thelow, intermediate and high physical levels (p < 0.001). In particular, women with low physical activity had higher totalGHQ scores compared to those with high physical activity had the lowest total GHQ scores. Moreover, women who wereobese (p < 0.001), diabetic (p < 0.001) and/or hypertensive (p < 0.001), complaining of vaginal dryness (p=0.02) and/orjoint and muscular discomfort (p < 0.001) had significantly higher total GHQ scores.Conclusion: Physical activity of menopausal women is significantly associated with their general health, as less activewomen had poor general health.
目的:本研究评估了体育活动在促进更年期妇女整体健康方面的作用。材料和方法:本横断面研究在埃及伊斯梅利亚的苏伊士运河大学医院进行。纳入了191名绝经期妇女。使用国际身体活动问卷(IPAQ)评估他们的身体活动,而通过28项一般健康问卷(GHQ)评估他们的一般健康状况。使用SPSS对数据进行分析,p值小于0.05时认为结果具有统计学意义。结果:大多数参与研究的女性有低到中等水平的身体活动,而其余的(24%)则有高水平的身体活动。我们发现一般健康量表在低、中、高体质水平之间存在统计学上的显著差异(p < 0.001)。特别是,体力活动少的女性总GHQ得分较高,而体力活动多的女性总GHQ得分最低。此外,肥胖(p < 0.001)、糖尿病(p < 0.001)和/或高血压(p < 0.001)、自诉阴道干燥(p=0.02)和/或关节和肌肉不适(p < 0.001)的女性GHQ总分显著较高。结论:绝经期妇女的身体活动与她们的总体健康状况显著相关,因为运动较少的妇女总体健康状况较差。
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引用次数: 1
Measurement of Cerebro-Placental Doppler Ratio and Amniotic Fluid Index as a Predictor of Perinatal Outcome in Prolonged Pregnancy 测定脑胎盘多普勒比和羊水指数作为延长妊娠围产儿结局的预测因子
Pub Date : 2020-11-01 DOI: 10.21608/ebwhj.2020.20645.1064
N. Rabei, M. Taha, M. Etman, O. Naser
Background: The terms post-term, prolonged, postdates and post mature are often loosely used interchangeably to signifypregnancies that have exceeded a duration considered to be the upper limit of normal.Objective: The aim of this work was to study the role of Doppler velocimetry of the umbilical and middle cerebral arteriesrepresented by the cerebroplacental ratio and amniotic fluid volume in the prediction of adverse fetal outcome in post-termpregnancies.Materials and Methods: This is a prospective case control study conducted at Ain-Shams University Teaching Hospitalfor Obstetrics and Gynecology, Egypt. The study included 50 pregnant patients who were divided into two groups; group1included 25 pregnant ladies with gestational age of 41 weeks attending the casuality department in labour or in prodromaof labor. while, group 2 included 25 pregnant ladies with gestational age of 41 weeks not in labor and reaching thehospital for ANC, who were selected for termination based on the biophysical profile and poor Doppler indices or CTGchanges. All patients were submitted to antenatal fetal surveillance tests including modified biophysical profile (MBPP)which consists of the non-stress test (NST), amniotic fluid index (AFI), and color Doppler velocimetry of fetoplacentaland fetal vessels including MCA PI, UA PI, and CPR. The accuracy of cerebroplacental ratios (the middle cerebral arteryPI divided by the umbilical artery PI) and amniotic fluid volume as a means of predicting intrauterine fetal distress andadverse perinatal outcome in post-term pregnancies.Results: Cerebroplacental ratio showed the highest sensitivity (95%) in comparison with other parameters, so it is a goodtest to reassure the obstetricians of the fetal well being. Prominent changes in AFI (i.e. 5.0 cm. Asignificant association with FHR decelerations and presence of meconium is proved to exist when AFI is <5.0 cm.Conclusion: The addition of cerebral/umbilical ratios to antenatal surveillance protocols is expected to improve the perinataloutcome. It should be tried in the various high risk pregnancies whenever uteroplacental insufficiency is suspected.
背景:术语“产后”、“延长”、“产后”和“产后”经常被松散地交替使用,以表示超过正常上限的妊娠。目的:研究以脑胎盘比和羊水容量为代表的脐动脉和大脑中动脉多普勒血流速度测定在预测妊娠后期不良胎儿结局中的作用。材料和方法:这是一项在埃及Ain-Shams大学妇产科教学医院进行的前瞻性病例对照研究。该研究包括50名孕妇,她们被分为两组;第1组为25例胎龄为41周的产妇,在产房或产程前段就诊。第二组为25例胎龄为41周,未临产且到医院进行非分娩分娩的孕妇,根据生物物理特征、差的多普勒指数或ctgchange选择终止妊娠。所有患者均接受了产前胎儿监测测试,包括改进的生物物理特征(MBPP),包括非应激测试(NST)、羊水指数(AFI)、胎儿胎盘和胎儿血管的彩色多普勒测速,包括MCA PI、UA PI和心肺复苏术。脑胎盘比值(大脑中动脉PI除以脐动脉PI)和羊水容量作为预测宫内胎儿窘迫和不良围产期结局的准确性结果:与其他指标相比,脑胎盘比的敏感性最高(95%),是产科医生对胎儿健康放心的良好指标。AFI变化明显(即5.0 cm。当AFI <5.0 cm时,与FHR减速和胎便存在显著关联。结论:在产前监测方案中加入脑/脐带比值有望改善围产儿结局。当怀疑子宫胎盘功能不全时,应在各种高危妊娠中尝试。
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引用次数: 1
Gene polymorphisms and risk of preeclampsia in Egyptian women 基因多态性与埃及妇女先兆子痫的风险
Pub Date : 2020-11-01 DOI: 10.21608/EBWHJ.2019.19794.1056
M. Ibrahem, Magdy M. Ibrahim, A. Al-Karamany, R. Etewa
Aim: The aim of this study was to evaluate the possible association between ACE I/D, AT1 receptor 1166 A:C, AT2receptor-1332 A:G, and MMP-9-1562 C:T polymorphisms and risk of preeclampsia in Egyptian women.Materials and Methods: This case-control study included 108 pregnant women was allocated into two groups, 54pre-eclamptic women group and control group which included 54 normotensive pregnant women. Genotyping of AT1 1166A:C and AT2 −1332 A: G were performed by duplex polymerase chain reaction-restriction fragment length polymorphismPCR-RFLP. Genotyping of I/D polymorphism of ACE was carried out by PCR and genotyping of MMP-9 −1562C/T wasperformed by tetra-primer amplification refractory mutation system T- ARMS–PCR.Results: The DD genotype of ACE gene was significantly associated with increased risk of preeclampsia[OR (95% CI) = 2.47 (0.72–8.5), p = 0.02] and the D allele was significantly associated with an increased risk ofpreeclampsia [OR (95% CI) = 1.95 (1.08–3.54), p = 0.02]. The AT2 GG genotype frequency was significantly higher inpreeclampsia [OR (95% CI) = 3.24 (1.25–8.41), p = 0.002] and the G allele [OR (95% CI) = 2.41 (1.39–4.18), p = 0.002].  However, the AT1 CC and MMP9 TT genotypes frequency were insignificantly associated with preeclampsia.Conclusion: ACE gene I/D and -1332A/G of AT2 receptor polymorphisms, but not AT1 receptor gene A1166C andMMP-9 (-1562 C/T) polymorphisms, could be related to the risk of preeclampsia in Egyptian women.
目的:本研究的目的是评估ACE I/D、AT1受体1166 A:C、at2受体-1332 A:G和MMP-9-1562 C:T多态性与埃及妇女先兆子痫风险之间的可能关联。材料与方法:将108例孕妇分为两组,先兆子痫组54例,对照组54例血压正常孕妇。采用双链聚合酶链反应-限制性片段长度多态性mpcr - rflp对AT1 1166A:C和AT2−1332 A: G进行基因分型。对ACE的I/D多态性进行PCR分型,对MMP-9−1562C/T进行四引物扩增难突变系统T- ARMS-PCR分型。结果:ACE基因DD基因型与子痫前期风险增加显著相关[OR (95% CI) = 2.47 (0.72-8.5), p = 0.02], D等位基因与子痫前期风险增加显著相关[OR (95% CI) = 1.95 (1.08-3.54), p = 0.02]。AT2 GG基因型频率在子痫前期显著增高[OR (95% CI) = 3.24 (1.25 ~ 8.41), p = 0.002]和G等位基因[OR (95% CI) = 2.41 (1.39 ~ 4.18), p = 0.002]。然而,AT1 CC和MMP9 TT基因型频率与子痫前期无显著相关性。结论:ACE基因I/D和AT2受体-1332A/G多态性与埃及女性子痫前期发病风险有关,而AT1受体基因A1166C和mmp -9 (-1562 C/T)多态性与此无关。
{"title":"Gene polymorphisms and risk of preeclampsia in Egyptian women","authors":"M. Ibrahem, Magdy M. Ibrahim, A. Al-Karamany, R. Etewa","doi":"10.21608/EBWHJ.2019.19794.1056","DOIUrl":"https://doi.org/10.21608/EBWHJ.2019.19794.1056","url":null,"abstract":"Aim: The aim of this study was to evaluate the possible association between ACE I/D, AT1 receptor 1166 A:C, AT2receptor-1332 A:G, and MMP-9-1562 C:T polymorphisms and risk of preeclampsia in Egyptian women.Materials and Methods: This case-control study included 108 pregnant women was allocated into two groups, 54pre-eclamptic women group and control group which included 54 normotensive pregnant women. Genotyping of AT1 1166A:C and AT2 −1332 A: G were performed by duplex polymerase chain reaction-restriction fragment length polymorphismPCR-RFLP. Genotyping of I/D polymorphism of ACE was carried out by PCR and genotyping of MMP-9 −1562C/T wasperformed by tetra-primer amplification refractory mutation system T- ARMS–PCR.Results: The DD genotype of ACE gene was significantly associated with increased risk of preeclampsia[OR (95% CI) = 2.47 (0.72–8.5), p = 0.02] and the D allele was significantly associated with an increased risk ofpreeclampsia [OR (95% CI) = 1.95 (1.08–3.54), p = 0.02]. The AT2 GG genotype frequency was significantly higher inpreeclampsia [OR (95% CI) = 3.24 (1.25–8.41), p = 0.002] and the G allele [OR (95% CI) = 2.41 (1.39–4.18), p = 0.002].  However, the AT1 CC and MMP9 TT genotypes frequency were insignificantly associated with preeclampsia.Conclusion: ACE gene I/D and -1332A/G of AT2 receptor polymorphisms, but not AT1 receptor gene A1166C andMMP-9 (-1562 C/T) polymorphisms, could be related to the risk of preeclampsia in Egyptian women.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131060232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using β hCG, prolactin and IGFBP I single or in Pairs to diagnose PROM 利用β hCG、催乳素和IGFBP I单独或成对诊断早膜PROM
Pub Date : 2020-11-01 DOI: 10.21608/ebwhj.2020.21883.1069
M. El-Ghannam, H. T. Khairy, M. Mohammad, Mohammed Saeed El Din El Safty, Amira Abozeid
Background: When diagnosing premature rupture membranes is query, choosing the appropriate management needsadditional confirmatory test. Based on their metabolomics, some biochemical markers have been proposed as diagnosticaids. A perfect test could be composed of combining more than one marker. Combining markers is not arbitrary as somecombinations could inversely impact the diagnostic accuracy of the test.Aim: Improving sensitivity and specificity of diagnosis of preterm premature rupture of membranes by combining quantitativeinsulin like growth factor binding protein 1 (IGFBP-1) with quantitative βHCG and/or quantitative prolactin in cervicovaginalfluid.Materials and Methods: It is a cross sectional study. IGFBP-1, prolactin and β-HCG concentrations in vaginal fluid wereexamined in 180 patients with sure membrane state and the diagnostic accuracy of each marker and each combination wasdetermined. The study was conducted between January 2018 and September 2018 in Ain-Shams University MaternityHospital after the approval of the institutional ethics committee. Informed consent has been obtained from the patientsbefore participation.Results: The sensitivity, specificity, PPV, and NPV of Prolactin with cutoff point 11 μIU/ml are 84.4, 73.2, 73.8,and 79.5, respectively, gives accuracy percentage 75.4%. The sensitivity, specificity, PPV, and NPV of ILGFBP-1 withcutoff point 102 μIU/ml are 88.3, 93.5, 100, and 69.4 respectively gives accuracy percentage 81.5%. The sensitivity,specificity, PPV, and NPV of Β-HCG with cutoff point 104 mIU/mL are 85.1, 83.9, 96.2, and 72.8 respectively givesaccuracy percentage 79.9%. The sensitivity, specificity, PPV, and NPV of the combination of IGFBP-1 and β-HCGare 78.4, 100, 100 and 64 respectively gives accuracy percentage 89.7. The sensitivity, specificity, PPV, and NPV of thecombination of IGFBP-1 and prolactin are 78.4, 100, 100 and 68.7, respectively, gives accuracy percentage 84.2. Thesensitivity, specificity, PPV, and NPV of the combination of β-HCG and prolactin are 79.8, 100, 100 and 63.6 respectivelygives accuracy percentage 77.2.Conclusion:Combining IGFBP-1 and β-HCG is the best diagnostic combination to detect amniotic fluid presence invaginal fluid. Combined IGFBP-1 and prolactin offered very little improvement compared to IGFBP-1 alone. Addingprolactin to β-HCG decreased accuracy than each of the other two markers alone.
背景:在诊断早破膜有疑问时,选择合适的处理方法需要额外的确证性检查。基于它们的代谢组学,一些生化标记物被提出作为诊断辅助工具。一个完美的测试可以由多个标记组合而成。组合标记不是任意的,因为一些组合可能会对测试的诊断准确性产生相反的影响。目的:将胰岛素样生长因子结合蛋白1 (IGFBP-1)与宫颈阴道液中βHCG和/或催乳素定量结合,提高诊断早产胎膜早破的敏感性和特异性。材料与方法:采用横断面研究。测定180例膜状态确定的患者阴道液中IGFBP-1、催乳素和β-HCG的浓度,并测定各指标及各组合的诊断准确性。经机构伦理委员会批准,该研究于2018年1月至2018年9月在Ain-Shams大学妇产医院进行。参与前已获得患者的知情同意。结果:在截断点11 μIU/ml时,催乳素的灵敏度为84.4,特异度为73.2,PPV为73.8,NPV为79.5,准确率为75.4%。在截断点为102 μIU/ml时,ILGFBP-1的灵敏度为88.3,特异度为93.5,PPV为100,NPV为69.4,准确率为81.5%。Β-HCG的灵敏度、特异度、PPV和NPV分别为85.1、83.9、96.2和72.8,截断点为104 mIU/mL,准确率为79.9%。IGFBP-1与β- hcga联合检测的敏感性、特异性、PPV和NPV分别为78.4、100、100和64,准确率为89.7。IGFBP-1与催乳素联合检测的敏感性为78.4,特异性为100,PPV为100,NPV为68.7,准确率为84.2。β-HCG与催乳素联合检测的敏感性、特异性、PPV、NPV分别为79.8、100、100、63.6,准确率为77.2。结论:结合IGFBP-1和β-HCG是检测羊水存在的最佳诊断组合。与单独使用IGFBP-1相比,IGFBP-1和催乳素联合使用的改善甚微。在β-HCG中加入催乳素比单独使用其他两种标记物降低了准确性。
{"title":"Using β hCG, prolactin and IGFBP I single or in Pairs to diagnose PROM","authors":"M. El-Ghannam, H. T. Khairy, M. Mohammad, Mohammed Saeed El Din El Safty, Amira Abozeid","doi":"10.21608/ebwhj.2020.21883.1069","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.21883.1069","url":null,"abstract":"Background: When diagnosing premature rupture membranes is query, choosing the appropriate management needsadditional confirmatory test. Based on their metabolomics, some biochemical markers have been proposed as diagnosticaids. A perfect test could be composed of combining more than one marker. Combining markers is not arbitrary as somecombinations could inversely impact the diagnostic accuracy of the test.Aim: Improving sensitivity and specificity of diagnosis of preterm premature rupture of membranes by combining quantitativeinsulin like growth factor binding protein 1 (IGFBP-1) with quantitative βHCG and/or quantitative prolactin in cervicovaginalfluid.Materials and Methods: It is a cross sectional study. IGFBP-1, prolactin and β-HCG concentrations in vaginal fluid wereexamined in 180 patients with sure membrane state and the diagnostic accuracy of each marker and each combination wasdetermined. The study was conducted between January 2018 and September 2018 in Ain-Shams University MaternityHospital after the approval of the institutional ethics committee. Informed consent has been obtained from the patientsbefore participation.Results: The sensitivity, specificity, PPV, and NPV of Prolactin with cutoff point 11 μIU/ml are 84.4, 73.2, 73.8,and 79.5, respectively, gives accuracy percentage 75.4%. The sensitivity, specificity, PPV, and NPV of ILGFBP-1 withcutoff point 102 μIU/ml are 88.3, 93.5, 100, and 69.4 respectively gives accuracy percentage 81.5%. The sensitivity,specificity, PPV, and NPV of Β-HCG with cutoff point 104 mIU/mL are 85.1, 83.9, 96.2, and 72.8 respectively givesaccuracy percentage 79.9%. The sensitivity, specificity, PPV, and NPV of the combination of IGFBP-1 and β-HCGare 78.4, 100, 100 and 64 respectively gives accuracy percentage 89.7. The sensitivity, specificity, PPV, and NPV of thecombination of IGFBP-1 and prolactin are 78.4, 100, 100 and 68.7, respectively, gives accuracy percentage 84.2. Thesensitivity, specificity, PPV, and NPV of the combination of β-HCG and prolactin are 79.8, 100, 100 and 63.6 respectivelygives accuracy percentage 77.2.Conclusion:Combining IGFBP-1 and β-HCG is the best diagnostic combination to detect amniotic fluid presence invaginal fluid. Combined IGFBP-1 and prolactin offered very little improvement compared to IGFBP-1 alone. Addingprolactin to β-HCG decreased accuracy than each of the other two markers alone.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129292528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Vaginal misoprostol versus carbetocin in decreasing blood loss in abdominal momectomy : Randomized controlled trial 阴道米索前列醇与卡霉素减少腹部肿瘤切除术出血量:随机对照试验
Pub Date : 2020-11-01 DOI: 10.21608/ebwhj.2019.19210.1053
A. S. El-Houssieny, M. E. Mohamed, H. Allam, D. Atef
Background: Uterine fibroids are the most common female pelvic tumors occurring in about 15% to 30% of women in thereproductive age. When fibroids are associated with symptoms surgical intervention is often indicated.Aim: The aim of the study is to evaluate the efficacy of administration of carbetocin in comparison to vaginal misoprostol in decreasing blood loss in women undergoing abdominal myomectomy.  Materials and Methods: The present study is a randomized controlled study carried out in Ain-Shams University Maternity Hospitals. The study included 44 women with age ranged from 25 to 40 years old, subjects were distributed randomly into two equal groups; group 1 included 22 patients who will receive 400 ug misoprostol vaginally, one hour preoperative. Group 2 included 22 patients who will receive bolus of 100 ug carbetocin slowly intravenously once starting anesthesia.  Results: Laboratory investigations in this study revealed that there was no statistical significant difference between study groups as regards age, BMI and Parity, Preoperative hemoglobin and HCT (P >0.05). As regards postoperative investigations of Hb and HCT highly statistical significant difference between study groups was found between both groups (P 0.05).  Conclusion: These results showed no statistical difference was found between misoprostol and cabetocin groups in estimated blood loss, calculated estimated blood loss, need for blood transfusion and hospital stay.
背景:子宫肌瘤是最常见的女性盆腔肿瘤,约占育龄妇女的15%至30%。当肌瘤与症状相关时,通常需要手术干预。目的:本研究的目的是评价卡贝霉素与阴道米索前列醇在减少腹部子宫肌瘤切除术妇女失血方面的疗效。材料与方法:本研究是在Ain-Shams大学妇产医院进行的随机对照研究。该研究包括44名年龄在25岁至40岁之间的女性,受试者被随机分为两组;组1包括22例患者,术前1小时阴道给予400ug米索前列醇。第2组22例患者在开始麻醉后缓慢静脉滴注卡贝菌素100 ug。结果:本研究实验室调查显示,两组患者年龄、BMI、胎次、术前血红蛋白、HCT差异均无统计学意义(P >0.05)。术后Hb、HCT检查两组间差异有显著统计学意义(P < 0.05)。结论:米索前列醇组与卡霉素组在估计失血量、计算估计失血量、输血需要量和住院时间方面无统计学差异。
{"title":"Vaginal misoprostol versus carbetocin in decreasing blood loss in abdominal momectomy : Randomized controlled trial","authors":"A. S. El-Houssieny, M. E. Mohamed, H. Allam, D. Atef","doi":"10.21608/ebwhj.2019.19210.1053","DOIUrl":"https://doi.org/10.21608/ebwhj.2019.19210.1053","url":null,"abstract":"Background: Uterine fibroids are the most common female pelvic tumors occurring in about 15% to 30% of women in thereproductive age. When fibroids are associated with symptoms surgical intervention is often indicated.Aim: The aim of the study is to evaluate the efficacy of administration of carbetocin in comparison to vaginal misoprostol in decreasing blood loss in women undergoing abdominal myomectomy.  Materials and Methods: The present study is a randomized controlled study carried out in Ain-Shams University Maternity Hospitals. The study included 44 women with age ranged from 25 to 40 years old, subjects were distributed randomly into two equal groups; group 1 included 22 patients who will receive 400 ug misoprostol vaginally, one hour preoperative. Group 2 included 22 patients who will receive bolus of 100 ug carbetocin slowly intravenously once starting anesthesia.  Results: Laboratory investigations in this study revealed that there was no statistical significant difference between study groups as regards age, BMI and Parity, Preoperative hemoglobin and HCT (P >0.05). As regards postoperative investigations of Hb and HCT highly statistical significant difference between study groups was found between both groups (P 0.05).  Conclusion: These results showed no statistical difference was found between misoprostol and cabetocin groups in estimated blood loss, calculated estimated blood loss, need for blood transfusion and hospital stay.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114495829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complications Associated with First-trimester Surgical Abortion at Ain-Shams Maternity Hospital over the period from January 1, 2016 to December 31, 2017 2016年1月1日至2017年12月31日期间Ain-Shams妇产医院妊娠早期手术流产相关并发症
Pub Date : 2020-09-01 DOI: 10.21608/ebwhj.2020.26278.1085
Amr Riad Yasser, Yasser Abou-Talib, Rania Ragab, M. Nawara
Background: First trimester surgical abortion is a common obstetric procedure with some known complications.Objective: The aim of this study was to examine the incidence of major complications of first trimester surgical abortion in Ain-Shams Maternity Hospital.Patients and Methods: Retrospective record-based case series in which records of patients who underwent first trimester surgical abortion in the period from January 1st, 2016 till December 31st, 2017 were examined.Results: A total of 1003 patients underwent first trimester surgical abortion. The overall major complication rate was 18.2%. There was a higher incidence of one or major complications in patients with previous abortions (P-value <0.002), valve replacement (P- value 0.001), missed and septic abortions, those requiring cervical dilatation, less hemoglobin, higher total leucocytic count, higher PTT.Conclusion: First trimester surgical abortion is a relatively safe procedure with hemorrhage being the most common complication.
背景:妊娠早期手术流产是一种常见的产科手术,有一些已知的并发症。目的:了解Ain-Shams妇产医院妊娠早期手术流产主要并发症的发生率。患者与方法:回顾性分析2016年1月1日至2017年12月31日期间妊娠早期手术流产患者的病例。结果:1003例患者行妊娠早期手术流产。主要并发症总发生率为18.2%。既往流产(P值<0.002)、瓣膜置换术(P值0.001)、流产漏诊和败血性流产、宫颈扩张、血红蛋白较低、总白细胞计数较高、PTT较高的患者出现一种或主要并发症的发生率较高。结论:妊娠早期手术流产是一种相对安全的手术,出血是最常见的并发症。
{"title":"Complications Associated with First-trimester Surgical Abortion at Ain-Shams Maternity Hospital over the period from January 1, 2016 to December 31, 2017","authors":"Amr Riad Yasser, Yasser Abou-Talib, Rania Ragab, M. Nawara","doi":"10.21608/ebwhj.2020.26278.1085","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.26278.1085","url":null,"abstract":"Background: First trimester surgical abortion is a common obstetric procedure with some known complications.Objective: The aim of this study was to examine the incidence of major complications of first trimester surgical abortion in Ain-Shams Maternity Hospital.Patients and Methods: Retrospective record-based case series in which records of patients who underwent first trimester surgical abortion in the period from January 1st, 2016 till December 31st, 2017 were examined.Results: A total of 1003 patients underwent first trimester surgical abortion. The overall major complication rate was 18.2%. There was a higher incidence of one or major complications in patients with previous abortions (P-value <0.002), valve replacement (P- value 0.001), missed and septic abortions, those requiring cervical dilatation, less hemoglobin, higher total leucocytic count, higher PTT.Conclusion: First trimester surgical abortion is a relatively safe procedure with hemorrhage being the most common complication.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131477079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Thyroid Function in Pregnant Females Attending Suez Canal University Hospital 苏伊士运河大学医院孕妇甲状腺功能评估
Pub Date : 2020-09-01 DOI: 10.21608/ebwhj.2019.17496.1026
Ahmed Abdel-Monem Abo El-Roose, N. Al-Imam, A. M. El-Deib, G. Tawfik
contribute to these changes. These factors could contribute to thyroid dysfunction during pregnancy especially when adeficiency of iodine intake exists and when thyroid reserve is not sufficient.Aim: To study thyroid functions in pregnant women avoiding maternal and fetal complications associated with thyroiddysfunctions.Materials and Methods: A cross-sectional study was carried out on 100 pregnant women attending Obstetrics OutpatientClinic in Suez-Canal University Hospitals were invited to enroll in the study. At the end of study, the blood samples wereassessed for free T3, free T4 and TSH.Results: This study revealed that most of the pregnant women had normal thyroid functions (51%), while subclinicalhypothyroidism (39%) was the most prevalent disorder followed by clinical hypothyroidism (6%) and isolatedhypothyroxinemia (4%).Conclusion: The most prevalent pattern of thyroid dysfunction in pregnant women was subclinical hypothyroidism.
为这些变化做出贡献。这些因素可能导致孕期甲状腺功能障碍,特别是在碘摄入不足和甲状腺储备不足的情况下。目的:研究孕妇甲状腺功能,避免与甲状腺功能障碍相关的母胎并发症。材料与方法:对在苏伊士运河大学附属医院产科门诊就诊的100名孕妇进行横断面研究。在研究结束时,评估血液样本的游离T3,游离T4和TSH。结果:大多数孕妇甲状腺功能正常(51%),其中亚临床甲状腺功能减退(39%)最为常见,其次是临床甲状腺功能减退(6%)和孤立性甲状腺功能减退(4%)。结论:亚临床甲状腺功能减退是孕妇甲状腺功能障碍最常见的类型。
{"title":"Assessment of Thyroid Function in Pregnant Females Attending Suez Canal University Hospital","authors":"Ahmed Abdel-Monem Abo El-Roose, N. Al-Imam, A. M. El-Deib, G. Tawfik","doi":"10.21608/ebwhj.2019.17496.1026","DOIUrl":"https://doi.org/10.21608/ebwhj.2019.17496.1026","url":null,"abstract":"contribute to these changes. These factors could contribute to thyroid dysfunction during pregnancy especially when adeficiency of iodine intake exists and when thyroid reserve is not sufficient.Aim: To study thyroid functions in pregnant women avoiding maternal and fetal complications associated with thyroiddysfunctions.Materials and Methods: A cross-sectional study was carried out on 100 pregnant women attending Obstetrics OutpatientClinic in Suez-Canal University Hospitals were invited to enroll in the study. At the end of study, the blood samples wereassessed for free T3, free T4 and TSH.Results: This study revealed that most of the pregnant women had normal thyroid functions (51%), while subclinicalhypothyroidism (39%) was the most prevalent disorder followed by clinical hypothyroidism (6%) and isolatedhypothyroxinemia (4%).Conclusion: The most prevalent pattern of thyroid dysfunction in pregnant women was subclinical hypothyroidism.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133547801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Ovarian and Uterine Blood Flow Indices in Patients with Unexplained Infertility Undergoing ICSI and their Relation to Clinical Pregnancy Rate 不明原因不孕症行ICSI患者卵巢和子宫血流指标与临床妊娠率的关系
Pub Date : 2020-09-01 DOI: 10.21608/ebwhj.2020.20626.1062
A. Ibrahim, Mohamed Mohamed El-Mandooh, Haitham Fathy Mohammed Gad, H. Hariri
Background: Infertility is defined by the World Health Organisation (WHO) as a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse and is estimated to affect as many as 48.5 million couples worldwide. Unexplained infertility (UI) constitutes an important portion of the infertility reasons (up to 30%) and is diagnosed when the causes of male or female infertility remains unknown.Aim: The aim of the study was to compare ovarian, uterine artery and subendometrial vessels resistance by measuring PI and RI of patients diagnosed as UI undergoing ICSI in the day of embryo transfer and control group diagnosed as fertile by having at least one livebirth in peri-implantation period from day 19 to day 21.Materials and Methods:The current study is a prospective case control study, which was conducted at the Assisted Reproduction Technology unit of Ain Shams University Maternity Hospital during the period from September 2017 to July 2019. The current study included two groups of patients one group is unexplained infertility attending the Assisted Reproduction Unit and the other is control fertile group each group consists of 51 women.Results: There was statistically significant difference between the unexplained infertility group and control fertile group as regard Uterine and subendometrial artery PI, RI and ovarian artery RI in which resistance indexes was significantly higher in the UI group than control group. The cut off values of PI, RI between unexplained infertility and fertile group are ≥1.88, ≥0.8 for Uterine artery, and ≥ 0.87, ≥0.53 for subendometrial arteries, and ≥ 0.59 for ovarian artery RI. Among the unexplained infertility undergoing ICSI patients the pregnancy rate is 23.5%. There was no statistically significant difference between the two groups (pregnant group and non-pregnant group) as regard the age, BMI, duration of infertility or the basal hormonal profile.Conclusion: Doppler parameters are useful tools to assess endometrial receptivity in unexplained infertility patients undergoing ICSI. This study found that Uterine, Ovarian, subendometrial arteries plasticity index (PI) and resistance index RI measured on the day of embryo transfer higher than fertile women and have value in judging endometrial receptivity and predict the final outcome of IVF/ ICSI- ET. Uterine, ovarian and subendometrial blood flow assessed by measuring PI, RI of these arteries was impaired in unexplained infertility patients compared to fertile women. Also, uterine arteries PI, ovarian and subendometrial arteries PI, RI differ in pregnancy outcome in unexplained infertility patients undergoing ICSI.
背景:世界卫生组织(WHO)将不孕症定义为一种生殖系统疾病,其特征是常规无保护性交12个月或更长时间后仍未实现临床妊娠。据估计,全世界有多达4850万对夫妇受到不孕症的影响。不明原因不孕症(UI)是不孕症原因的重要组成部分(高达30%),在男性或女性不孕症的原因尚不清楚时诊断出来。目的:本研究的目的是通过测量胚胎移植当天诊断为UI的ICSI患者和在着床期19 ~ 21天至少有一次活产诊断为可生育的对照组的PI和RI来比较卵巢、子宫动脉和子宫内膜下血管阻力。材料与方法:本研究为前瞻性病例对照研究,于2017年9月至2019年7月在艾因沙姆斯大学妇产医院辅助生殖技术部门进行。目前的研究包括两组患者,一组是不明原因的不孕症,另一组是控制生育的组,每组由51名妇女组成。结果:不明原因不孕组子宫及子宫内膜下动脉PI、RI、卵巢动脉RI与正常生育组比较差异有统计学意义,其中UI组阻力指标明显高于对照组。不明原因不孕症组与可生育组的PI、RI截断值子宫动脉≥1.88、≥0.8,子宫内膜下动脉≥0.87、≥0.53,卵巢动脉RI≥0.59。不明原因不孕症行ICSI患者妊娠率为23.5%。两组(怀孕组和非怀孕组)在年龄、BMI、不孕持续时间和基础激素谱方面无统计学差异。结论:多普勒参数是评估不明原因不孕症行ICSI患者子宫内膜容受性的有效工具。本研究发现,在胚胎移植当天测量的子宫、卵巢、子宫内膜下动脉可塑性指数(PI)和阻力指数RI高于可育女性,对判断子宫内膜容受性和预测IVF/ ICSI- ET的最终结局有价值。不明原因不孕症患者通过测量这些动脉的PI和RI来评估子宫、卵巢和子宫内膜下血流量,与可育女性相比,这些动脉的PI和RI受损。此外,子宫动脉PI、卵巢和子宫内膜下动脉PI、RI在接受ICSI的不明原因不孕症患者的妊娠结局中存在差异。
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引用次数: 6
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Evidence Based Womenʼs Health Journal
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