Pub Date : 2020-12-06DOI: 10.21608/ebwhj.2019.17521.1028
H. T. Khairy, M. Ibrahim, Rasha W. Abdul Hadi, Hossam El-Taweel
Background: O3 therapy induces moderate oxidative stress when interacting with lipids. Aim of the Work: to demonstrate the efficacy of the application of vaginal ozone insufflations in treatment of recurrent CANDIDAL vulvo-vaginitis , compared to combined vaginal and systemic antifungal agents. Patients and Methods: This randomized-controlled study was conducted on 50 women with recurrent vulvo-vaginitis, recruited from the outpatient gynecology clinic of Ain shams University Obstetrics and Gynecology Hospital, who were attending for outpatient consultation. Subjects were assigned randomly into two groups, group (A) 25 subjects, who were treated with traditional, combined, topical and systemic antifungal therapy, and (b) Group (B): 25 subjects, who were treated by vaginal ozone insufflations. Results: Twenty-two (88%) patients in the vaginal ozone group had clinical cure compared with only 14 (56%) patients in the traditional treatment group. This difference was statistically significant. Likewise, the microbiological cure rate was significantly higher in the vaginal ozone group compared with the traditional treatment group. Five out of 14 patients (35.7%) in the traditional treatment group suffered clinical recurrence compared with only 1 out of 22 patients (4.5%) in the vaginal ozone group. This difference was statistically significant. Likewise, the microbiological recurrence rate was significantly lower in the vaginal ozone group compared with the traditional treatment group. Conclusion: Ozone therapy has proven to be effective in treatment of the recurrent vulvovaginitis, where the persistence of clinical symptoms and positive culture exudates were measured.
{"title":"Vaginal Ozone Insufflation in the Treatment of Recurrent Candidal Vulvovaginitis: Randomized Control Trial","authors":"H. T. Khairy, M. Ibrahim, Rasha W. Abdul Hadi, Hossam El-Taweel","doi":"10.21608/ebwhj.2019.17521.1028","DOIUrl":"https://doi.org/10.21608/ebwhj.2019.17521.1028","url":null,"abstract":"Background: O3 therapy induces moderate oxidative stress when interacting with lipids. Aim of the Work: to demonstrate the efficacy of the application of vaginal ozone insufflations in treatment of recurrent CANDIDAL vulvo-vaginitis , compared to combined vaginal and systemic antifungal agents. Patients and Methods: This randomized-controlled study was conducted on 50 women with recurrent vulvo-vaginitis, recruited from the outpatient gynecology clinic of Ain shams University Obstetrics and Gynecology Hospital, who were attending for outpatient consultation. Subjects were assigned randomly into two groups, group (A) 25 subjects, who were treated with traditional, combined, topical and systemic antifungal therapy, and (b) Group (B): 25 subjects, who were treated by vaginal ozone insufflations. Results: Twenty-two (88%) patients in the vaginal ozone group had clinical cure compared with only 14 (56%) patients in the traditional treatment group. This difference was statistically significant. Likewise, the microbiological cure rate was significantly higher in the vaginal ozone group compared with the traditional treatment group. Five out of 14 patients (35.7%) in the traditional treatment group suffered clinical recurrence compared with only 1 out of 22 patients (4.5%) in the vaginal ozone group. This difference was statistically significant. Likewise, the microbiological recurrence rate was significantly lower in the vaginal ozone group compared with the traditional treatment group. Conclusion: Ozone therapy has proven to be effective in treatment of the recurrent vulvovaginitis, where the persistence of clinical symptoms and positive culture exudates were measured.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129991773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-06DOI: 10.21608/ebwhj.2019.17220.1021
Ahmed K. Awad, S. Habib, D. Mansour
Methods:A prospective study was conducted in Ain shams Maternity Hospital, in the period between Sep '18 and Feb '19.Outcome measures:Maternal outcome measures included: Estimated blood loss, Amount of blood transfusion, Mode of delivery, Complications, pre and postoperative hemoglobin level, Postoperative fever, Postoperative wound infection, ICU admission.Neonatal outcome measures included: Neonatal weight, APGAR score, Prematurity, NICU admission, IUFD.ResultsMean age (31.82 yrs), gravidity (4.06), parity (2.71), previous CS deliveries (2.52). Other RF: EC normal(42.4%), moderately depressed (40%), severely depressed(17.6%). At 5 minutes; normal(85.9%) moderately depressed(10.6%), severely depressed(3.5%). NICU admission(22.4%). IUFD (5.9%). ConclusionPlacenta previa patients at risk of numerous maternal and neonatal morbidities, maternal morbidities include life threatening haemorrhage, caesarean hysterectomy, blood component transfusion, prolonged hospital stay and ICU admission. Neonatal morbidities include premature delivery, low birth weight, intrauterine foetal death and NICU admission.
{"title":"Maternal and Fetal Outcome of Placenta Previa Patients Attending Ain Shams University Maternity Hospital -Prospective Study","authors":"Ahmed K. Awad, S. Habib, D. Mansour","doi":"10.21608/ebwhj.2019.17220.1021","DOIUrl":"https://doi.org/10.21608/ebwhj.2019.17220.1021","url":null,"abstract":"Methods:A prospective study was conducted in Ain shams Maternity Hospital, in the period between Sep '18 and Feb '19.Outcome measures:Maternal outcome measures included: Estimated blood loss, Amount of blood transfusion, Mode of delivery, Complications, pre and postoperative hemoglobin level, Postoperative fever, Postoperative wound infection, ICU admission.Neonatal outcome measures included: Neonatal weight, APGAR score, Prematurity, NICU admission, IUFD.ResultsMean age (31.82 yrs), gravidity (4.06), parity (2.71), previous CS deliveries (2.52). Other RF: EC normal(42.4%), moderately depressed (40%), severely depressed(17.6%). At 5 minutes; normal(85.9%) moderately depressed(10.6%), severely depressed(3.5%). NICU admission(22.4%). IUFD (5.9%). ConclusionPlacenta previa patients at risk of numerous maternal and neonatal morbidities, maternal morbidities include life threatening haemorrhage, caesarean hysterectomy, blood component transfusion, prolonged hospital stay and ICU admission. Neonatal morbidities include premature delivery, low birth weight, intrauterine foetal death and NICU admission.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126676456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-06DOI: 10.21608/EBWHJ.2019.17470.1023
Ezeldin Mohamed, M. E. M. Mohamed, M. A. Taha, I. Abozeid
Aim of The Work: Comparing AMH to other parameters of ovarian reserve (OR) in evaluating the effect of laparoscopic ovarian drilling (LOD) on OR in treatment of PCO.Results: The mean AMH level before the operation was 6.9±1.4 ng/ml & 8.2±1.4 ng/ml for the patients who got pregnant and those who did not get pregnant respectively. While the mean AMH level after 3 months of the operation was 5.1±1.1 ng/ml & 6.3±1.4 ng/ml for the patients who got pregnant and those who did not get pregnant respectively. The mean LH/FSH ratio before the operation was 2.04±0.5 & 3.02±0.6 for the patients who got pregnant and those who did not get pregnant respectively. While the mean LH/FSH ratio after 3 months of the operation was 1.15±0.2 & 1.93±0.6 for the patients who got pregnant and those who did not get pregnant respectively. The mean inhibin B level before the operation was 52.5±2.2 pg/ml & 52.6±3.9 pg/ml for the patients who got pregnant and those who did not get pregnant respectively. While the mean inhibin B level after 3 months of the operation was 48.3±2.1 pg/ml & 49.1±3.6 pg/ml for the patients who got pregnant and those who did not get pregnant respectively.Conclusion: Pregnancy rates were significantly related to the preoperative LH/FSH ratio & AMH levels when comparing the cases that got pregnant with the cases who did not conceive postoperatively in patients of polycystic ovary syndrome (PCOS), whereas preoperative Inhibin B level had no relation to pregnancy rates .
{"title":"The effect of Laparoscopic Ovarian Drilling on Anti-Müllerian Hormone, LH/FSH ratio & Inhibin B","authors":"Ezeldin Mohamed, M. E. M. Mohamed, M. A. Taha, I. Abozeid","doi":"10.21608/EBWHJ.2019.17470.1023","DOIUrl":"https://doi.org/10.21608/EBWHJ.2019.17470.1023","url":null,"abstract":"Aim of The Work: Comparing AMH to other parameters of ovarian reserve (OR) in evaluating the effect of laparoscopic ovarian drilling (LOD) on OR in treatment of PCO.Results: The mean AMH level before the operation was 6.9±1.4 ng/ml & 8.2±1.4 ng/ml for the patients who got pregnant and those who did not get pregnant respectively. While the mean AMH level after 3 months of the operation was 5.1±1.1 ng/ml & 6.3±1.4 ng/ml for the patients who got pregnant and those who did not get pregnant respectively. The mean LH/FSH ratio before the operation was 2.04±0.5 & 3.02±0.6 for the patients who got pregnant and those who did not get pregnant respectively. While the mean LH/FSH ratio after 3 months of the operation was 1.15±0.2 & 1.93±0.6 for the patients who got pregnant and those who did not get pregnant respectively. The mean inhibin B level before the operation was 52.5±2.2 pg/ml & 52.6±3.9 pg/ml for the patients who got pregnant and those who did not get pregnant respectively. While the mean inhibin B level after 3 months of the operation was 48.3±2.1 pg/ml & 49.1±3.6 pg/ml for the patients who got pregnant and those who did not get pregnant respectively.Conclusion: Pregnancy rates were significantly related to the preoperative LH/FSH ratio & AMH levels when comparing the cases that got pregnant with the cases who did not conceive postoperatively in patients of polycystic ovary syndrome (PCOS), whereas preoperative Inhibin B level had no relation to pregnancy rates .","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132818475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-06DOI: 10.21608/ebwhj.2020.30842.1097
K. Salama
Background: Despite the high number of frozen embryo transfer cycles being conducted, there is much debate about which protocol for endometrial preparation is ideal. The aim of this study is detect the value of GNRH a in the preparation of the endometrium regarding the cycle outcome. Methodes: One hundred forty women participated in the study. .They were randomly divided into two groups; Group 1 and Group 2. The patients of group 1 received injection of GnRH-a triptoreline (3.75 mg) on the day-21 of the menstrual cycle preceding the replacement cycle. Both groups received exogenous estradiol starting from the second day of the cycle then the dose was increased incrementally till the endometrial thickness was ≥ 8mm or more. Progesterone was given to the patients before embryo transfer and continued thereafter. Twelve days later, serum pregnancy test was done and if positive, transvaginal ultrasonography was done two weeks later for detection of embryo cardiac activity. Results: Both groups showed no statistically significant differences regarding demographic, clinical and laboratory data and their relations to pregnancy. Serum pregnancy tests detected chemical pregnancy that was confirmed by transvaginal ultrasonography at 6 weeks gestation in only 49.3% of women (clinical pregnancy rate =49.3%). Only six women aborted at 8-12 weeks gestation (ongoing pregnancy rate =45%). There were no significant differences between both groups regarding the clinical outcome.Conclusion: Addition of GNRH a to HRT to prepare the endometrium in the FTE transfer cycle had no significant effect on the clinical outcome.
{"title":"Is addition of GNRH agonist to HRT significant in improving the outcome in FTE transfer cycles? Randomized study.","authors":"K. Salama","doi":"10.21608/ebwhj.2020.30842.1097","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.30842.1097","url":null,"abstract":"Background: Despite the high number of frozen embryo transfer cycles being conducted, there is much debate about which protocol for endometrial preparation is ideal. The aim of this study is detect the value of GNRH a in the preparation of the endometrium regarding the cycle outcome. Methodes: One hundred forty women participated in the study. .They were randomly divided into two groups; Group 1 and Group 2. The patients of group 1 received injection of GnRH-a triptoreline (3.75 mg) on the day-21 of the menstrual cycle preceding the replacement cycle. Both groups received exogenous estradiol starting from the second day of the cycle then the dose was increased incrementally till the endometrial thickness was ≥ 8mm or more. Progesterone was given to the patients before embryo transfer and continued thereafter. Twelve days later, serum pregnancy test was done and if positive, transvaginal ultrasonography was done two weeks later for detection of embryo cardiac activity. Results: Both groups showed no statistically significant differences regarding demographic, clinical and laboratory data and their relations to pregnancy. Serum pregnancy tests detected chemical pregnancy that was confirmed by transvaginal ultrasonography at 6 weeks gestation in only 49.3% of women (clinical pregnancy rate =49.3%). Only six women aborted at 8-12 weeks gestation (ongoing pregnancy rate =45%). There were no significant differences between both groups regarding the clinical outcome.Conclusion: Addition of GNRH a to HRT to prepare the endometrium in the FTE transfer cycle had no significant effect on the clinical outcome.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"232 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115965928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-06DOI: 10.21608/ebwhj.2019.17059.1019
M. Khairy
Objectives: To determine whether vitamin D-binding protein (VDBP) in cervicovaginal fluid (CVF) is independently predictive of imminent spontaneous preterm delivery (SPTD, delivery within 48 hours) in women with preterm labor with intact membranes (PTL).Patients and Methods: This was a single-center observational cohort study. CVF samples for VDBP assays were obtained along with serum C-reactive protein (CRP) levels in consecutive women with PTL (n = 94) between 23.0 and 37.0 weeks of gestation. VDBP levels in CVF were determined by enzyme-linked immunosorbent assay kits. The primary outcome measures were SPTD within 48 hours after sampling..Results: In the multivariable analysis, elevated VDBP levels in CVF samples of PTL women were significantly associated with imminent preterm delivery, even after adjusting for potential confounders (e.g., gestational age at sampling, parity, and serum CRP). In women with PTL, the areas under receiver operating characteristic curves of CVF VDBP level for predicting imminent preterm delivery were 0.781, with cut-off values of 2.3 μg/mL (sensitivity of 63.16% and specificity of 96.0%). respectively. The CVF VDBP levels were significantly high in women with PTL.Conclusion: VDBP in the CVF independently predicts imminent preterm delivery in women with PTL.
{"title":"Vitamin D-Binding Protein in Cervicovaginal Fluid as a Non-Invasive Predictor of Maternal and Fetal Outcome in Women with Preterm Labor","authors":"M. Khairy","doi":"10.21608/ebwhj.2019.17059.1019","DOIUrl":"https://doi.org/10.21608/ebwhj.2019.17059.1019","url":null,"abstract":"Objectives: To determine whether vitamin D-binding protein (VDBP) in cervicovaginal fluid (CVF) is independently predictive of imminent spontaneous preterm delivery (SPTD, delivery within 48 hours) in women with preterm labor with intact membranes (PTL).Patients and Methods: This was a single-center observational cohort study. CVF samples for VDBP assays were obtained along with serum C-reactive protein (CRP) levels in consecutive women with PTL (n = 94) between 23.0 and 37.0 weeks of gestation. VDBP levels in CVF were determined by enzyme-linked immunosorbent assay kits. The primary outcome measures were SPTD within 48 hours after sampling..Results: In the multivariable analysis, elevated VDBP levels in CVF samples of PTL women were significantly associated with imminent preterm delivery, even after adjusting for potential confounders (e.g., gestational age at sampling, parity, and serum CRP). In women with PTL, the areas under receiver operating characteristic curves of CVF VDBP level for predicting imminent preterm delivery were 0.781, with cut-off values of 2.3 μg/mL (sensitivity of 63.16% and specificity of 96.0%). respectively. The CVF VDBP levels were significantly high in women with PTL.Conclusion: VDBP in the CVF independently predicts imminent preterm delivery in women with PTL.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123794959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-06DOI: 10.21608/ebwhj.2019.17205.1020
A. H. Amin, Nadeen Sherif, A. Askalani, Shaza SaadAlla
Aim to compare individual predictors as AMH, AFC versus the ovarian response prediction index in determining the ovarian response to controlled ovarian stimulation Methods A prospective cohort study conducted on 84 infertile couples candidate for Intracytoplasmic sperm injection (ICSI) for the first time using either long agonist or antagonist protocol according to clinical evaluation. Participants were classified according to the number of MII oocytes into poor response with 3 or less oocytes and normal responders with 4 or more oocytesResults Women with poor response were statistically older than those with normal ovarian response (33.1±5.9 vs. 29.8±5.4 respectively).The number of cumulus (12.1±5.2 vs. 2.5±1.5) , MII oocytes (7.8±3.6 vs. 2±0.8), grade A embryos (3±0.8 vs. 1.4±0.9) and total number of embryos (3.8±2.2 vs. 1.7±0.7) were significantly higher in normal responders .ORPI has the highest accuracy n predicting ovarian response (88%) when compared to AMH (83%)and AFC (86%) .Conclusion AMH, AFC and ORPI are good predictive of the ovarian response and help in choosing the protocol and gonadotropin dose of induction and prediction of OHSS.
目的比较AMH、AFC与卵巢反应预测指数等个体预测指标对卵巢对控制性卵巢刺激反应的影响。方法对84对首次接受卵胞浆内单精子注射(ICSI)的不育夫妇进行前瞻性队列研究，根据临床评价采用长效激动剂或拮抗剂方案。根据MII卵母细胞的数量将参与者分为3个及以下的不良反应和4个及以上的正常反应。结果不良反应的女性比卵巢正常反应的女性年龄大(分别为33.1±5.9∶29.8±5.4)。正常反应者的卵丘数(12.1±5.2 vs. 2.5±1.5)、MII卵母细胞数(7.8±3.6 vs. 2±0.8)、A级胚胎数(3±0.8 vs. 1.4±0.9)和胚胎总数(3.8±2.2 vs. 1.7±0.7)显著高于正常反应者，ORPI预测卵巢反应的准确率(88%)高于AMH(83%)和AFC(86%)。结论AMH、AFC和ORPI对卵巢反应有较好的预测效果，有助于选择诱导和预测OHSS的方案和促性腺激素剂量。
{"title":"Comparative study between ovarian response prediction index versus anti-Müllerian hormone, antral follicular count as predictors of ovarian response in women undergoing IVF/ICSI cycles","authors":"A. H. Amin, Nadeen Sherif, A. Askalani, Shaza SaadAlla","doi":"10.21608/ebwhj.2019.17205.1020","DOIUrl":"https://doi.org/10.21608/ebwhj.2019.17205.1020","url":null,"abstract":"Aim to compare individual predictors as AMH, AFC versus the ovarian response prediction index in determining the ovarian response to controlled ovarian stimulation Methods A prospective cohort study conducted on 84 infertile couples candidate for Intracytoplasmic sperm injection (ICSI) for the first time using either long agonist or antagonist protocol according to clinical evaluation. Participants were classified according to the number of MII oocytes into poor response with 3 or less oocytes and normal responders with 4 or more oocytesResults Women with poor response were statistically older than those with normal ovarian response (33.1±5.9 vs. 29.8±5.4 respectively).The number of cumulus (12.1±5.2 vs. 2.5±1.5) , MII oocytes (7.8±3.6 vs. 2±0.8), grade A embryos (3±0.8 vs. 1.4±0.9) and total number of embryos (3.8±2.2 vs. 1.7±0.7) were significantly higher in normal responders .ORPI has the highest accuracy n predicting ovarian response (88%) when compared to AMH (83%)and AFC (86%) .Conclusion AMH, AFC and ORPI are good predictive of the ovarian response and help in choosing the protocol and gonadotropin dose of induction and prediction of OHSS.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131080512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-06DOI: 10.21608/ebwhj.2020.26230.1081
Iman Abu Gleda, S. S. Hassan, M.R.C.O.G. Abdel-Hafeez, Ahmed Hamed
Objective: assess the association between serum level of Vitamin D and pregnancy outcome in women with unexplained infertility undergoing an induction of ovulation. Methods: cohort study including women with unexplained infertility .Results: the vitamin D level was significantly higher in pregnant women than non pregnant. After adjustment for the effect of other variables, there was no statistically significant relation between vitamin D level and chemical pregnancy. On the other hand, secondary infertility was an independent predictor of chemical pregnancy. Our results showed that vitamin D level has limited predictive value with an area under the ROC curve (AUC) of 0.621. The best cutoff is a value of >32.5 ng/mL, which has a sensitivity of 28% and specificity of 95%. There is weak negative correlation between serum vitamin D and LH level. Lastly, after adjustment for the effect of other variables, adequate vitamin D and secondary infertility were an independent predictors of chemical pregnancy. There was significantly high rate of positive chemical pregnancy test among women had sufficient serum vitamin D when compared to those had deficient/ insufficient serum vitamin D.Conclusion: There was no statistically significant relation between vitamin D level and pregnancy outcome in women with unexplained infertility undergoing induction of ovulation. Moreover, our results showed that vitamin D level has limited predictive value in women with unexplained infertility undergoing induction of ovulation, the best cutoff value was >32.5 ng/mL. After adjustment for the effect of other variables, adequate vitamin D was an independent predictors of chemical pregnancy.
{"title":"The Relation between Vitamin D Level and Pregnancy Outcome in Women with Unexplained Infertility Undergoing Induction of Ovulation","authors":"Iman Abu Gleda, S. S. Hassan, M.R.C.O.G. Abdel-Hafeez, Ahmed Hamed","doi":"10.21608/ebwhj.2020.26230.1081","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.26230.1081","url":null,"abstract":"Objective: assess the association between serum level of Vitamin D and pregnancy outcome in women with unexplained infertility undergoing an induction of ovulation. Methods: cohort study including women with unexplained infertility .Results: the vitamin D level was significantly higher in pregnant women than non pregnant. After adjustment for the effect of other variables, there was no statistically significant relation between vitamin D level and chemical pregnancy. On the other hand, secondary infertility was an independent predictor of chemical pregnancy. Our results showed that vitamin D level has limited predictive value with an area under the ROC curve (AUC) of 0.621. The best cutoff is a value of >32.5 ng/mL, which has a sensitivity of 28% and specificity of 95%. There is weak negative correlation between serum vitamin D and LH level. Lastly, after adjustment for the effect of other variables, adequate vitamin D and secondary infertility were an independent predictors of chemical pregnancy. There was significantly high rate of positive chemical pregnancy test among women had sufficient serum vitamin D when compared to those had deficient/ insufficient serum vitamin D.Conclusion: There was no statistically significant relation between vitamin D level and pregnancy outcome in women with unexplained infertility undergoing induction of ovulation. Moreover, our results showed that vitamin D level has limited predictive value in women with unexplained infertility undergoing induction of ovulation, the best cutoff value was >32.5 ng/mL. After adjustment for the effect of other variables, adequate vitamin D was an independent predictors of chemical pregnancy.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132003952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-06DOI: 10.21608/ebwhj.2019.17714.1036
A. Nada, Emad R. Issak, Khaled M. Kholaif, H. Torkey, I. Fawzy, Reham A. Mohsen
Objective: To measure the impacts of cervical traction on the uterine artery hemodynamics.Methods: This study was a randomized-controlled trial. The primary outcome measure was the uterine artery hemodynamics indices: end diastolic velocity (EDV) and systolic/diastolic velocity ratio (S/D ratio).Main Results: The study was conducted in one institution in Cairo from January-2017 to March-2017 with 12-month follow up period. Both groups were comparable (p-value > 0.05) with regard to the age, BMI, heart rate, blood pressure, gravidity, parity as well as episiotomy. There was no difference (P> 0.05) between the two groups regarding vital signs after the intervention. All the patients tolerated the procedure with mild sedation. PSV, EDV, S/D, PI & RI were comparable between both groups before the intervention. However, PSV, S/D ratio, RI & PI were significantly higher (p-values < 0.001) in the study group than the control group after the intervention. On the other hand, EDV was significantly lower in the study group than the control group after the intervention (p-value < 0.001). During the follow-up period, no adverse events reported.Conclusion: Amr’s maneuver is effective in changing the uterine artery hemodynamics indices in the direction of decreasing the uterine artery blood flow.
{"title":"Uterine artery hemodynamic changes due to a Cervical Traction maneuver (Amr’s maneuver); Randomized Controlled Study","authors":"A. Nada, Emad R. Issak, Khaled M. Kholaif, H. Torkey, I. Fawzy, Reham A. Mohsen","doi":"10.21608/ebwhj.2019.17714.1036","DOIUrl":"https://doi.org/10.21608/ebwhj.2019.17714.1036","url":null,"abstract":"Objective: To measure the impacts of cervical traction on the uterine artery hemodynamics.Methods: This study was a randomized-controlled trial. The primary outcome measure was the uterine artery hemodynamics indices: end diastolic velocity (EDV) and systolic/diastolic velocity ratio (S/D ratio).Main Results: The study was conducted in one institution in Cairo from January-2017 to March-2017 with 12-month follow up period. Both groups were comparable (p-value > 0.05) with regard to the age, BMI, heart rate, blood pressure, gravidity, parity as well as episiotomy. There was no difference (P> 0.05) between the two groups regarding vital signs after the intervention. All the patients tolerated the procedure with mild sedation. PSV, EDV, S/D, PI & RI were comparable between both groups before the intervention. However, PSV, S/D ratio, RI & PI were significantly higher (p-values < 0.001) in the study group than the control group after the intervention. On the other hand, EDV was significantly lower in the study group than the control group after the intervention (p-value < 0.001). During the follow-up period, no adverse events reported.Conclusion: Amr’s maneuver is effective in changing the uterine artery hemodynamics indices in the direction of decreasing the uterine artery blood flow.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128839599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-06DOI: 10.21608/ebwhj.2020.20283.1059
Dina Naguib, K. Diab, M. Nawara
Background: Labor induction is the initiation of labor at a viable pregnancy duration by artificial means, and occurs before the spontaneous onset of labor. The goal of labor induction is to achieve a timely and uncomplicated vaginal delivery with minimal adverse effects on the mother or newborn.Objective: To compare the efficacy of the use of foleys catheter with either misoprostol or placebo to improve induction to delivery interval in women with unfavorable cervix undergoing induction of labor. Patients and Methods: The present study is a randomized double blind controlled study that was conducted at Maternity hospital of Ain Shams university. The study included 100 candidates on 4 equal goups:50 nulliparas randomized into 2 groups and 50 multiparas randomized into 2 groups. Each group underwent labor induction by Foleys catheter and Misoprostol or placebo.Results: labor stages were significantly shorter in combined group than in Foley's group,but no significant difference in third stage. Oxytocin duration and total dose were significantly lower in combined group. No significant difference among studied groups regarding mode of delivery or fetal or maternal complications. Conclusion: Combined Foleys catheter and misoprostol provides a shorter duration of cervical ripening, less oxytocin required with no added complications compared to Foleys catheter alone.
{"title":"Foley's Catheter with or without Misoprostol in Induction of labor: (Randomised Double Blind Control Study)","authors":"Dina Naguib, K. Diab, M. Nawara","doi":"10.21608/ebwhj.2020.20283.1059","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.20283.1059","url":null,"abstract":"Background: Labor induction is the initiation of labor at a viable pregnancy duration by artificial means, and occurs before the spontaneous onset of labor. The goal of labor induction is to achieve a timely and uncomplicated vaginal delivery with minimal adverse effects on the mother or newborn.Objective: To compare the efficacy of the use of foleys catheter with either misoprostol or placebo to improve induction to delivery interval in women with unfavorable cervix undergoing induction of labor. Patients and Methods: The present study is a randomized double blind controlled study that was conducted at Maternity hospital of Ain Shams university. The study included 100 candidates on 4 equal goups:50 nulliparas randomized into 2 groups and 50 multiparas randomized into 2 groups. Each group underwent labor induction by Foleys catheter and Misoprostol or placebo.Results: labor stages were significantly shorter in combined group than in Foley's group,but no significant difference in third stage. Oxytocin duration and total dose were significantly lower in combined group. No significant difference among studied groups regarding mode of delivery or fetal or maternal complications. Conclusion: Combined Foleys catheter and misoprostol provides a shorter duration of cervical ripening, less oxytocin required with no added complications compared to Foleys catheter alone.","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114478866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-06DOI: 10.21608/ebwhj.2020.27971.1087
A. Sameh, M. Abdellatif, M. Ibrahim, R. Ghanem
Background: Operative hysteroscopy with lysis of intrauterine adhesions is a viable treatment option for Asherman syndrome. However, with all forms of adhesion resection, there is a high rate of reformation of intrauterine adhesions. The current study will focus on a unique technique to evaluate the use of platelet rich plasma over an inflated balloon versus conventional method (inflated balloon).Objective: To assess the efficacy of the platelet rich plasma in preventing reformation of intrauterine adhesions after adhesiolysis in cases of asherman syndrome. Patients and Methods: This study was conducted in Ain Shams Maternity hospital (Early Cancer Detection and Endoscopy Unit) during the period between July 2019 and February 2020. 40 patients seeking for conception with a history of primary or secondary infertility with severe intrauterine adhesions. 20 patients (case) injected with PRP and 20 patients (control) with IU balloon.Results: Our study shown a significant increase of menses duration among the PRP group post-operative (3.0±1.1) days and preoperative menses duration (1.5±1.4) days. Compared to balloon post-operative (1.9±1.6) and preoperative (1.5±1.6) days. Our study shown significant increase of menses amount among the PRP group post-operative (5.2±3.7) pads, and preoperative menses duration (1.0±1.0) pads. Compared to balloon post-operative (2.9±3.2) and preoperative (0.9±0.9) pads.Conclusion: Platelet rich plasma after operative hysteroscopy has high efficacy and safety in improvement of menses duration, amount and adhesion score in cases suffering from severe intrauterine adhesions and decreasing postoperative adhesions
{"title":"Intrauterine Use of Autologous Platelet-Rich Plasma in Management of Asherman Syndrome: A Randomized Controlled Trial","authors":"A. Sameh, M. Abdellatif, M. Ibrahim, R. Ghanem","doi":"10.21608/ebwhj.2020.27971.1087","DOIUrl":"https://doi.org/10.21608/ebwhj.2020.27971.1087","url":null,"abstract":"Background: Operative hysteroscopy with lysis of intrauterine adhesions is a viable treatment option for Asherman syndrome. However, with all forms of adhesion resection, there is a high rate of reformation of intrauterine adhesions. The current study will focus on a unique technique to evaluate the use of platelet rich plasma over an inflated balloon versus conventional method (inflated balloon).Objective: To assess the efficacy of the platelet rich plasma in preventing reformation of intrauterine adhesions after adhesiolysis in cases of asherman syndrome. Patients and Methods: This study was conducted in Ain Shams Maternity hospital (Early Cancer Detection and Endoscopy Unit) during the period between July 2019 and February 2020. 40 patients seeking for conception with a history of primary or secondary infertility with severe intrauterine adhesions. 20 patients (case) injected with PRP and 20 patients (control) with IU balloon.Results: Our study shown a significant increase of menses duration among the PRP group post-operative (3.0±1.1) days and preoperative menses duration (1.5±1.4) days. Compared to balloon post-operative (1.9±1.6) and preoperative (1.5±1.6) days. Our study shown significant increase of menses amount among the PRP group post-operative (5.2±3.7) pads, and preoperative menses duration (1.0±1.0) pads. Compared to balloon post-operative (2.9±3.2) and preoperative (0.9±0.9) pads.Conclusion: Platelet rich plasma after operative hysteroscopy has high efficacy and safety in improvement of menses duration, amount and adhesion score in cases suffering from severe intrauterine adhesions and decreasing postoperative adhesions","PeriodicalId":224226,"journal":{"name":"Evidence Based Womenʼs Health Journal","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114709361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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