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Fertility preservation in female cancer sufferers: (only) a moral obligation? 保留女性癌症患者的生育能力:(仅仅)一种道德义务?
Pub Date : 2022-03-17 DOI: 10.1080/13625187.2022.2045936
S. Zaami, Michael Stark, F. Signore, G. Gullo, E. Marinelli
Abstract Purpose Advances in cancer diagnostics and therapeutics have thankfully led to high numbers of young cancer survivors, although some interventions may sometimes threaten fertility. The authors aimed to assess how evidence-based oncofertility counselling can be adequately fulfilled for the sake of female cancer patients, in light of its complexities and multidisciplinary nature, which require thorough counselling and consent pathways. Materials and Methods A search has been conducted in the databases PubMed/MEDLINE, Web of Science, Scopus, EMBASE and Google Scholar via search strings such as fertility preservation, reproductive counselling, oncofertility, cancer survivors, in order to identify relevant meaningful sources spanning the 2010–2021 period. Results Counselling needs to be implemented in compliance with international guidelines, so as to avoid medicolegal repercussions. Albeit fertility preservation is supported by most health care institutions, actual conditions at health care facilities often reflect several lingering difficulties in the oncofertility process. Oncofertility counselling should foster access to fertility preservation procedures. To best serve that purpose, it should be implemented in a manner consistent with ethical and legal standards, so that patients can make an informed decision based on comprehensive and relevant data. Conclusions Counselling needs to be rooted in a close cooperation of oncologists, reproductive endocrinologists, mental health counsellors and clinical researchers. The provision of oncofertility services is grounded in the moral obligation to uphold individual autonomy, which is essential in a free society, unless the exercise thereof could pose a risk to the children conceived or to others.
癌症诊断和治疗的进步带来了大量的年轻癌症幸存者,尽管一些干预措施有时可能会威胁到生育能力。鉴于其复杂性和多学科性质,作者旨在评估基于证据的癌症生育咨询如何能够为女性癌症患者充分实现,这需要彻底的咨询和同意途径。材料和方法在PubMed/MEDLINE、Web of Science、Scopus、EMBASE和Google Scholar等数据库中检索生育力保存、生殖咨询、肿瘤生育、癌症幸存者等关键词,以确定2010-2021年期间相关的有意义的文献来源。结果咨询工作应遵循国际准则,避免产生医学法律后果。尽管大多数保健机构都支持保留生育能力,但保健机构的实际情况往往反映出在肿瘤生育过程中存在一些挥之不去的困难。癌症生育咨询应促进获得保留生育能力的程序。为了最好地达到这一目的,应该以符合道德和法律标准的方式实施,以便患者能够根据全面和相关的数据做出明智的决定。咨询需要植根于肿瘤学家、生殖内分泌学家、心理健康咨询师和临床研究人员的密切合作。提供生育服务的基础是维护个人自主权的道德义务,这在自由社会中是必不可少的,除非行使这种自主权可能对怀孕的儿童或他人构成危险。
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引用次数: 24
Intervening factors in health care professionals’ attitudes and behaviours towards comprehensive abortion care in the workplace: a comparative case study of Tanzania and Ethiopia 保健专业人员对工作场所全面堕胎护理的态度和行为的干预因素:坦桑尼亚和埃塞俄比亚的比较案例研究
Pub Date : 2022-03-03 DOI: 10.1080/13625187.2022.2039910
Dennis Munetsi, William J Ugarte
Abstract Purpose Health care professionals’ attitudes and behaviours play a fundamental role in the provision of timely comprehensive abortion care as a maternal health intervention and save hundreds of thousands of women’s lives, annually. This study explores underlying factors influencing Tanzanian and Ethiopian health care professionals’ attitudes and behaviours towards comprehensive abortion care between 2015 and 2020. Materials and methods The study inductively explored Ethiopian and Tanzanian health care professionals’ behaviours using a comparative case study design and a textual analytical approach. Published and unpublished literature, documents and newspapers were used as data sources. The two cases were selected because of their different approaches towards the governance of abortion care, one gradually legalising while the other persistently restricting. Results Results demonstrated that there are both subjective (beliefs, attitudes, images, pre-dispositions) and objective (institutional incapacity) factors that impact the actions of health care professionals in the work environment. Conclusions The study concluded that the intervention of subjective factors results from the institutional failure to effectively bridge the divide between governance and accessibility of safe abortion care.
摘要目的卫生保健专业人员的态度和行为在提供及时全面的流产护理作为孕产妇保健干预措施和每年挽救数十万妇女的生命方面发挥着根本作用。本研究探讨了2015年至2020年间影响坦桑尼亚和埃塞俄比亚卫生保健专业人员对全面堕胎护理的态度和行为的潜在因素。材料和方法本研究采用比较案例研究设计和文本分析方法,归纳探讨了埃塞俄比亚和坦桑尼亚卫生保健专业人员的行为。使用已发表和未发表的文献、文件和报纸作为数据来源。之所以选择这两个案例,是因为它们对堕胎护理的治理方式不同,一个是逐步合法化,另一个是持续限制。结果结果表明,影响卫生保健专业人员在工作环境中的行为既有主观因素(信念、态度、形象、倾向),也有客观因素(制度无能)。结论主观因素的干预是由于制度上未能有效地弥合安全人工流产护理的治理与可及性之间的鸿沟。
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引用次数: 1
Knowledge and attitudes of Lebanese women of childbearing age towards emergency contraception 黎巴嫩育龄妇女对紧急避孕的知识和态度
Pub Date : 2019-12-06 DOI: 10.1080/13625187.2019.1695118
Rima Hammoud, Sirine Saleh, Doha Halawani, H. Mezher, Azza Abou El Naga, Bilal Azakir
Abstract Objectives: Unwanted pregnancy is sometimes associated with unsafe abortion, which may lead to maternal death. Pregnancy after unprotected sexual intercourse can be avoided by using emergency contraception (EC). Our study aimed to assess the knowledge and attitudes of reproductive-aged Lebanese women towards EC use. Methods: A descriptive cross-sectional study was conducted by interviewing randomly selected women aged between 15 and 49 years from the five major Lebanese governates. A pre-tested, pre-structured questionnaire was applied composed of three parts: (1) personal information, (2) knowledge about EC methods and (3) attitude towards EC. Results: We found that 78% of participants had never heard of EC. Among those who had heard of EC, only 29.3% had good knowledge about it. Knowledge about EC was not, however, associated with participants’ sociodemographic characteristics (i.e., age, marital status, educational level and background, occupation and occupational field and area of residence). There was a positive attitude towards EC among 57.3% of participants. Attitudes were statistically associated with level of education, area of residence and whether the respondent had ever heard of EC. Conclusion: Most Lebanese women of childbearing age lack knowledge about EC. There is a need to raise public awareness of EC.
目的:意外怀孕有时与不安全堕胎有关,这可能导致孕产妇死亡。无保护性交后的怀孕可以通过使用紧急避孕(EC)来避免。我们的研究旨在评估黎巴嫩育龄妇女对EC使用的知识和态度。方法:一项描述性横断面研究是通过采访随机选择的妇女从黎巴嫩五个主要省份年龄在15至49岁之间。本研究采用了一份预先测试的、预先结构化的问卷,由三个部分组成:(1)个人信息;(2)对电子商务方法的了解;(3)对电子商务的态度。结果:我们发现78%的参与者从未听说过EC。在听说过电子商务的受访者中,只有29.3%的人对电子商务有良好的了解。然而,对欧共体的了解与参与者的社会人口特征(即年龄、婚姻状况、教育水平和背景、职业和职业领域以及居住地区)无关。57.3%的受访者对电子商务持正面态度。从统计上看,态度与受教育程度、居住地区以及被调查者是否听说过欧共体有关。结论:大多数黎巴嫩育龄妇女缺乏EC相关知识。有必要提高公众对电子教育的认识。
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引用次数: 5
Implementation of reproductive life planning (RLP) in primary health care supported by an evidence-based website 在一个以证据为基础的网站的支持下,在初级卫生保健中实施生殖生活计划
Pub Date : 2019-11-28 DOI: 10.1080/13625187.2019.1695117
Melinda Koo Andersson, T. Tydén
Abstract Objectives: The aims of the study were to evaluate how well the reproductive life plan (RLP) tool was implemented in practice and explore the utility of the website www.reproduktivlivsplan.se for patient counselling. Methods: A cross-sectional study was conducted in 2018, in which 73 midwives in primary health care were asked to use the RLP tool and the website in their daily practice. Three months later, participants answered a questionnaire, based on normalisation process theory (NPT), about their implementation experience. Results: The response rate was 73% (n = 53). The mean length of midwifery experience was 15 years. Almost all respondents (89%) reported a positive attitude towards the tool and the website and their ability to use them in practice. The majority agreed to all statements about implementation of the RLP, according to NPT. Use of the RLP also made it easier for midwives to support clients in forming reproductive goals (85%, n = 45), give family planning advice (81%, n = 43), give advice about how to improve health before pregnancy (85%, n = 45) and give advice about how to preserve fertility (89%, n = 47). Nine out of ten respondents said they would recommend the website to other midwives. Conclusion: The RLP was well implemented among the respondents and the majority considered the website to be a useful tool. Long-term studies are needed to further elucidate the effects of the RLP on changes in health behaviour and pregnancy outcomes.
摘要目的:本研究的目的是评估生殖生命计划(RLP)工具在实践中的实施情况,并探讨www.reproduktivlivsplan.se网站对患者咨询的效用。方法:2018年进行了一项横断面研究,要求73名初级卫生保健助产士在日常实践中使用RLP工具和网站。三个月后,参与者根据正常化过程理论(NPT)回答了一份关于他们实施经验的问卷。结果:有效率为73% (n = 53)。助产经验的平均长度为15年。几乎所有的受访者(89%)都对该工具和网站以及他们在实践中使用它们的能力持积极态度。根据《不扩散核武器条约》,大多数国家同意关于实施RLP的所有声明。使用RLP还使助产士更容易支持客户制定生殖目标(85%,n = 45),提供计划生育咨询(81%,n = 43),就如何改善孕前健康提供咨询(85%,n = 45),并就如何保持生育能力提供咨询(89%,n = 47)。十分之九的受访者表示,他们会向其他助产士推荐该网站。结论:RLP在被调查者中得到了很好的实施,大多数人认为网站是一个有用的工具。需要进行长期研究,以进一步阐明RLP对健康行为变化和妊娠结局的影响。
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引用次数: 8
Comparison of change in body weight between contraception containing 30-μg ethinylestradiol/2-mg chlormadinone acetate or 30-μg ethinylestradiol/3-mg drospirenone: a randomised controlled trial 一项随机对照试验:30-μg炔雌醇/2-mg醋酸氯麦地那酮或30-μg炔雌醇/3-mg溴螺酮避孕药对体重变化的影响
Pub Date : 2019-11-22 DOI: 10.1080/13625187.2019.1688290
T. Wongwananuruk, Nalinee Panichyawat, Tachjaree Panchalee, P. Jirakittidul, S. Angsuwathana, Korakot Sirimai, Manopchai Thamkhantho, G. Chiravacharadej
Abstract Objectives: The aim of this study was to compare changes in body weight in women using a combined oral contraceptive (COC) consisting of 30-μg ethinylestradiol (EE) and 2-mg chlormadinone acetate (CMA) or a COC consisting of 30-μg EE and 3-mg drospirenone (DRSP). Methods: This randomised double-blind controlled trial (ClinicalTrials.gov NCT01608698) was conducted at a university hospital-based clinic in Thailand between June 2012 and September 2015. A total of 102 women were enrolled in the study, 99 of whom were randomised to EE/CMA (n = 45) or EE/DRSP (n = 54). Each participant was treated for six cycles. Body weight and other parameters as well as side effects were recorded at baseline and at the end of the third and sixth cycles of treatment. Results: A significant difference was observed in mean body weight change between the EE/CMA and EE/DRSP groups from both baseline to third cycle (0.51 ± 1.36 kg vs –0.43 ± 1.56 kg; p = .003) and baseline to sixth cycle (1.00 ± 1.84 kg vs –0.20 ± 2.23 kg; p = .013). The mean difference in body mass index and waist circumference had a similar trend to that of the mean difference in body weight. There was no significant difference in side effects between groups. Conclusion: A COC containing 30-µg EE/3-mg DRSP tended to confer a significantly more favourable change in body weight over a 6-month period compared with a COC containing 30-µg EE/2-mg CMA, which was associated with an increase in body weight.
摘要目的:比较30 μg炔雌醇(EE)和2 mg醋酸氯麦地那酮(CMA)组成的复方口服避孕药(COC)和30 μg EE和3 mg降螺酮(DRSP)组成的复方口服避孕药(COC)对女性体重的影响。方法:这项随机双盲对照试验(ClinicalTrials.gov NCT01608698)于2012年6月至2015年9月在泰国一家大学医院诊所进行。研究共纳入102名女性,其中99名随机分为EE/CMA组(n = 45)或EE/DRSP组(n = 54)。每位参与者治疗6个周期。在基线和第三和第六个治疗周期结束时记录体重和其他参数以及副作用。结果:EE/CMA组和EE/DRSP组从基线到第三周期的平均体重变化有显著差异(0.51±1.36 kg vs -0.43±1.56 kg;P = 0.003)和基线至第六个周期(1.00±1.84 kg vs -0.20±2.23 kg;p = .013)。体重指数和腰围的平均差值与体重的平均差值有相似的变化趋势。两组间副作用无显著差异。结论:与含有30µg EE/2 mg CMA的COC相比,含有30µg EE/3 mg DRSP的COC在6个月的时间内倾向于给体重带来更有利的变化,这与体重增加有关。
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引用次数: 3
Advantages of determining the fertile window with the individualised Natural Cycles algorithm over calendar-based methods 与基于日历的方法相比,使用个性化自然周期算法确定可育窗口的优点
Pub Date : 2019-11-02 DOI: 10.1080/13625187.2019.1682544
Thea K. Kleinschmidt, Jonathan R. Bull, V. Lavorini, S. Rowland, J. Pearson, E. B. Scherwitzl, R. Scherwitzl, K. Danielsson
Abstract Purpose: This study aims to compare the accuracy of fertile window identification with the contraceptive app Natural Cycles against the Rhythm Method and Standard Days Method (SDM). Materials and methods: Menstruation dates, basal body temperature (BBT), and luteinising hormone (LH) test results were collected anonymously from Natural Cycles app users. The fraction of green days (GDs) and wrong green days (WGDs) allocated by the various algorithms was determined over 12 cycles. For comparison of Natural Cycles and the Rhythm Method, 26,626 cycles were analysed. Results: Natural Cycles’ algorithms allocated 59% GDs (LH, BBT) in cycle 12, while the fraction of WGDs averaged 0.08%. The Rhythm Method requires monitoring of six cycles, resulting in no GDs or WGDs in cycle 1–6. In cycle 7, 49% GDs and 0.26% WGDs were allocated. GDs and WGDs decreased to 43% and 0.08% in cycle 12. The probabilities of WGDs on the day before ovulation with Natural Cycles were 0.31% (BBT) and 0% (LH, BBT), and 0.80% with the Rhythm Method. The probability of WGDs on the day before ovulation was 6.90% with the SDM. Conclusions: This study highlights that individualised algorithms are advantageous for accurate determination of the fertile window and that static algorithms are more likely to fail during the most fertile days
摘要目的:比较避孕应用程序“自然周期逆节律法”和“标准日法”(SDM)可育窗口识别的准确性。材料和方法:从Natural Cycles应用程序用户匿名收集月经日期、基础体温(BBT)和促黄体生成素(LH)检测结果。在12个周期内确定了各种算法分配的绿色天数(GDs)和错误绿色天数(wgd)的比例。为了比较自然周期和节奏方法,分析了26,626个周期。结果:Natural Cycles算法在第12周期分配了59%的GDs (LH, BBT),而WGDs的平均比例为0.08%。节律法需要监测6个周期,导致周期1-6无GDs或WGDs。在周期7中,分配了49%的GDs和0.26%的WGDs。在第12周期,GDs和WGDs分别下降到43%和0.08%。自然周期排卵前一天wgd的概率分别为0.31% (BBT)和0% (LH, BBT),节律法为0.80%。SDM在排卵前一天发生wgd的概率为6.90%。结论:本研究强调,个性化算法有利于准确确定受孕窗口,而静态算法在最容易受孕的日子更容易失败
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引用次数: 11
Differences in continuation rates and early removal between contraceptive and therapeutic use of the levonorgestrel-releasing intrauterine system 52 mg 避孕药和治疗性使用左炔诺孕酮释放宫内系统52毫克的延续率和早期清除的差异
Pub Date : 2019-11-02 DOI: 10.1080/13625187.2019.1682134
A. M. Teunissen, A. Merry, I. Devies, F. Roumen
Abstract Objective: To investigate differences in continuation rates between contraceptive and therapeutic use of the levonorgestrel-releasing intrauterine system 52 mg (LNG-IUS) and factors associated with early removal. Methods: Study design: Retrospective consecutive cohort design. Cohort: Women with the insertion of the LNG-IUS for contraceptive or therapeutic use from 1 January 2006 through 1 January 2009 at the Zuyderland Medical Centre, The Netherlands, with a follow-up of 5 years. The continuation period and reasons of early removal were noted. Univariable and multivariable analysis were performed. Results: Follow-up was possible in 2481 women, 1855 (74.8%) in the contraception group, and 626 (25.2%) in the therapy group. Multivariable Cox proportional hazards models showed, that therapeutic use was associated with an increased risk of early removal of the LNG-IUS (HR 1.23; 95% CI 1.08–1.41), as was having one child (HR 1.20; 95% CI 1.04–1.38), and a decreased risk with advancing age (HR 0.96; 95% CI 0.95–0.97). In both groups, an unacceptable bleeding pattern and adverse events were the main reasons of early removal, resulting in very low continuation rates over the years. Conclusion: Therapeutic use, having one child and a younger age are independent risk factors of early removal of the LNG-IUS, in contrast with previous LNG-IUS use which is associated with a lower risk. In both the contraception group and the therapy group, the main reasons for LNG-IUS discontinuation are continuation with a new LNG-IUS, and no more need for an LNG-IUS (for contraception or therapy). An unacceptable bleeding pattern or adverse events are associated with the lowest continuation rates in both groups.
摘要目的:探讨左炔诺孕酮释放宫内系统52 mg (LNG-IUS)在避孕和治疗方面的持续率差异及早期停用的相关因素。方法:研究设计:回顾性连续队列设计。队列:2006年1月1日至2009年1月1日在荷兰祖德兰医疗中心插入LNG-IUS用于避孕或治疗的妇女,随访5年。指出了提前撤职的延续期限和原因。进行单变量和多变量分析。结果:随访2481例,其中避孕组1855例(74.8%),治疗组626例(25.2%)。多变量Cox比例风险模型显示,治疗使用与早期移除LNG-IUS的风险增加相关(HR 1.23;95% CI 1.08-1.41),生育一个孩子也是如此(HR 1.20;95% CI 1.04-1.38),随着年龄的增长,风险降低(HR 0.96;95% ci 0.95-0.97)。在两组中,不可接受的出血模式和不良事件是早期切除的主要原因,导致多年来的持续率非常低。结论:治疗性使用、有一个孩子和年龄较小是早期拔除LNG-IUS的独立危险因素,而以前使用LNG-IUS的风险较低。在避孕组和治疗组中,LNG-IUS停药的主要原因是继续使用新的LNG-IUS,不再需要使用LNG-IUS(用于避孕或治疗)。不可接受的出血模式或不良事件与两组中最低的延续率相关。
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引用次数: 4
The abstract versus the concrete: differing opinions of medical residents in obstetrics and gynaecology about abortion and punishment of abortion 抽象与具体:妇产科住院医师对堕胎与堕胎处罚的不同看法
Pub Date : 2019-10-31 DOI: 10.1080/13625187.2019.1682135
S. F. Bento, R. Pacagnella, A. Faúndes, K. S. de Pádua, K. Fernandes, Danielle Miyamoto Araújo, I. Fahl, Maria José Duarte Osis, G. A. Duarte
Abstract Purpose: To investigate the opinions of Brazilian medical residents in Obstetrics and Gynaecology on abortion legislation according to their personal beliefs. Material and methods: A multicentre cross-sectional study. Residents at 21 university teaching hospitals completed a self-report questionnaire on their opinions in abstract terms, and about punishing women who abort in general and women they know. Results: In abstract terms, 8% favoured allowing abortion under any circumstances (fully liberal); 36% under socioeconomic or psychological constraints (broadly liberal); 75.3% opposed punishing a woman who has aborted (liberal in general practice); and 90.2% opposed punishing women they knew personally (liberal in personal practice). Not having a stable partner and not being influenced by religion were factors associated with liberal opinions. In personal practice, however, 80% of those who are influenced by religion were liberal. The percentage of respondents whose opinions were liberal was significantly greater among those who believed that abortion rates would remain the same or decrease following liberalisation. Conclusions: Judgements regarding the penalisation of women who abort are strongly influenced by how close the respondent is to the problem. Accurate information on abortion needs to be provided. Although about one third of the respondents were broadly liberal, the majority oppose punishment.
摘要目的:调查巴西妇产科住院医师按个人信仰对堕胎立法的看法。材料和方法:多中心横断面研究。21所大学教学医院的住院医生完成了一份自我报告问卷,内容涉及他们对抽象术语的看法,以及对一般堕胎妇女和他们认识的妇女进行惩罚的看法。结果:在抽象意义上,8%的人赞成在任何情况下都允许堕胎(完全自由);36%的人受社会经济或心理约束(大致自由);75.3%的人反对惩罚堕胎妇女(一般来说是自由派);90.2%的人反对惩罚他们认识的女性(在个人实践中是自由派)。没有稳定的伴侣和不受宗教影响是与自由观点相关的因素。然而,在个人实践中,受宗教影响的人中有80%是自由主义者。持自由主义观点的受访者比例明显高于那些认为堕胎率在自由化后将保持不变或下降的受访者。结论:关于对堕胎妇女的惩罚的判断,很大程度上取决于答复者对问题的了解程度。需要提供关于堕胎的准确信息。尽管大约三分之一的受访者是自由派,但大多数人反对惩罚。
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引用次数: 2
Pregnancy prevention and contraceptive preferences of online sex workers in the UK 英国网络性工作者的怀孕预防和避孕偏好
Pub Date : 2019-10-15 DOI: 10.1080/13625187.2019.1675624
P. Lowe, K. Pilcher, H. Pattison, V. Whittaker, Claire Robertson, J. Ross
Abstract Objectives: The internet has changed the organisation of sex work. The risk of sexually transmitted infections has frequently been a research focus, but less is known about sex workers’ use of contraception for pregnancy prevention. The aim of this research was to gain a better understanding of contraceptive preferences and provider interactions of online sex workers. Methods: Data were obtained from a multi-methods study of sex workers in the UK who advertise on the internet and have sexual contact with clients, particularly in the Birmingham and Solihull areas. The study comprised an online survey among 67 participants and eight qualitative interviews. Results: Reported high rates of condom use with clients led to sex workers considering pregnancy prevention to be a personal rather than an occupational issue. Disclosure of sex working to health professionals is often seen as unnecessary and/or undesirable due to concerns about stigma. A clear distinction between contraceptive needs for commercial and non-commercial partners was evident. Conclusion: Service providers need to take account of both personal and commercial needs during contraceptive consultations and avoid making assumptions based on homogeneous understandings of sex work. Encouraging disclosure of sex work to facilitate appropriate discussions may need new approaches to combat privacy and stigma concerns.
摘要目的:互联网改变了性工作的组织形式。性传播感染的风险经常是研究的重点,但对性工作者使用避孕措施预防怀孕的了解较少。这项研究的目的是为了更好地了解在线性工作者的避孕偏好和提供者之间的互动。方法:数据是从一项多方法研究中获得的,研究对象是英国的性工作者,他们在互联网上做广告,并与客户发生性接触,特别是在伯明翰和索利赫尔地区。该研究包括67名参与者的在线调查和8次定性访谈。结果:据报道,客户使用安全套的高比率导致性工作者认为预防怀孕是个人问题,而不是职业问题。由于担心耻辱,向卫生专业人员披露性工作往往被视为不必要和/或不受欢迎。商业伙伴和非商业伙伴对避孕药具的需要显然有明显的区别。结论:服务提供者在避孕咨询时需要考虑个人和商业需求,避免基于对性工作的同质理解做出假设。鼓励披露性工作以促进适当的讨论可能需要新的方法来解决隐私和耻辱问题。
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引用次数: 3
Thank you to Reviewers, 2019 感谢评论者,2019年
Pub Date : 2019-10-10 DOI: 10.1080/13625187.2019.1675979
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引用次数: 0
期刊
The European Journal of Contraception & Reproductive Health Care
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