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Professorships in child and adolescent psychiatry relative to a similarly sized medical specialty in the UK and Ireland: cross-sectional study - commentary, Sharma et al. 儿童和青少年精神病学教授相对于英国和爱尔兰类似规模的医学专业:横断面研究-评论,Sharma等。
Pub Date : 2025-11-03 DOI: 10.1192/bjp.2025.10462
Rajaei K Sharma,Katharine A Smith,Andrea Cipriani
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引用次数: 0
Mental health and suicidal ideation from 2010 to 2023 among university students: national repeated cross-sectional analysis 2010 - 2023年大学生心理健康与自杀意念:全国重复横断面分析
Pub Date : 2025-10-30 DOI: 10.1192/bjp.2025.10435
Børge Sivertsen, Jens C. Skogen, Keith J. Petrie, Rory C. O’Connor, Ann Kristin Skrindo Knudsen, Benedicte Kirkøen, Anne Reneflot, Kari-Jussie Lønning, Mari Hysing
Background

Mental health problems among university students have been on the rise, with particularly high levels reported during the COVID-19 pandemic. While many studies have examined the immediate effects of the pandemic, long-term trends in anxiety, depression, non-suicidal self-harm (NSSH) and suicidality remain less explored.

Aims

To investigate trends in mental health problems among Norwegian higher education students before, during and after the COVID-19 pandemic, focusing on anxiety, depression, NSSH and suicidality.

Method

The Students’ Health and Wellbeing Study (SHOT) is a national survey of Norwegian students, with data from six waves (2010–2023). Four primary waves (2010, 2014, 2018 and 2022) were supplemented by two additional waves during the COVID-19 pandemic (2021 and 2023), including nearly 200 000 students across all waves. Mental health outcomes were measured using the Hopkins Symptom Checklist(HSCL). Sex-specific cut-offs were applied to estimate the prevalence of major depressive episodes (MDE) and generalised anxiety disorder (GAD). Secondary outcomes included NSSH, suicidal thoughts and suicide attempts.

Results

Mental health problems increased consistently over the 13 years, with a more pronounced rise among women. Mean HSCL scores significantly increased for both sexes from 2010 to 2023, peaking during the COVID-19 lockdown in 2021, followed by a slight decline in 2022, but remaining higher than pre-pandemic levels. The prevalence of MDE and GAD followed similar patterns, increasing from 12.5 to 33.7% in women and 9.4 to 26.8% in men. Reports of NSSH also surged post-lockdown, particularly among women, while suicidal thoughts and attempts increased, especially in women, between 2021 and 2022.

Conclusion

Student mental health has worsened over the past decade. Although there was some post-pandemic improvement, rates of anxiety, depression and suicidality remain high. These findings underscore the continued importance of tiered mental health support and structural interventions within higher education to address student mental health.

大学生的心理健康问题一直在上升,在2019冠状病毒病大流行期间报告的水平尤其高。虽然许多研究调查了大流行病的直接影响,但对焦虑、抑郁、非自杀性自残和自杀行为的长期趋势探索较少。目的调查在2019冠状病毒病大流行之前、期间和之后,挪威高等教育学生心理健康问题的趋势,重点关注焦虑、抑郁、nsh和自杀。学生健康和福祉研究(SHOT)是一项针对挪威学生的全国性调查,数据来自2010-2023年的六次浪潮。在2019冠状病毒病大流行期间(2021年和2023年)补充了四次主要浪潮(2010年、2014年、2018年和2022年),包括所有浪潮中的近20万名学生。使用霍普金斯症状检查表(HSCL)测量心理健康结果。应用性别特异性截断值来估计重度抑郁发作(MDE)和广泛性焦虑症(GAD)的患病率。次要结局包括NSSH、自杀念头和自杀企图。结果13年来,心理健康问题持续增加,其中女性增加更为明显。从2010年到2023年,男女的平均HSCL得分均显著上升,在2021年COVID-19封锁期间达到峰值,随后在2022年略有下降,但仍高于大流行前的水平。MDE和GAD的患病率也有类似的模式,女性从12.5%增加到33.7%,男性从9.4%增加到26.8%。在封锁后,关于NSSH的报告也激增,尤其是女性,而在2021年至2022年期间,自杀念头和企图有所增加,尤其是女性。结论近十年来大学生心理健康状况不断恶化。虽然大流行后情况有所改善,但焦虑、抑郁和自杀率仍然很高。这些发现强调了在高等教育中分层心理健康支持和结构性干预对解决学生心理健康问题的持续重要性。
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引用次数: 0
Implementation of an integrated community-based suicide prevention programme, Gujarat, India: cluster randomised controlled trial 基于社区的综合自杀预防规划的实施,古吉拉特邦,印度:整群随机对照试验
Pub Date : 2025-10-30 DOI: 10.1192/bjp.2025.10431
Lakshmi Vijayakumar, Soumitra Pathare, Nikhil Jain, Deepa Pandit, Isha Lohumi, Jasmine Kalha, Laura Shields-Zeeman
Background

In low- and middle-income countries (LMICs), suicide is a major problem. Research on the effectiveness of large-scale suicide prevention interventions is limited.

Aims

To test the effectiveness of an integrated intervention (school-based prevention; reducing access to means of suicide; increased identification and management of suicide risk) in reducing deaths by suicide and suicide attempts; and to evaluate the implementation and effectiveness of sub-interventions.

Method

In this pragmatic cluster randomised controlled trial, 124 villages from Mehsana, India, were randomly assigned to either intervention or control arm. The intervention comprised school-based awareness intervention, community pesticide storage and training of community health workers (CHWs) to recognise, support, refer and follow up people at risk. Intention-to-treat analysis using mixed-effects Poisson regression tested the primary outcome (suicide attempts plus deaths by suicide), and multilevel linear models assessed sub-interventions. The primary outcome was captured through a novel suicide surveillance system.

Results

There was no statistically significant difference in the primary outcome between the intervention (54 of 62 consenting villages) and control (62 villages) arms. Separately, the intervention arm showed a 43% reduction in risk of death by suicide at 12 months (suicide rate 30.7 versus 43.6 per 100 000 person-years in intervention versus control arm; incidence rate ratio 0.57, 95% CI: 0.32–1.02, adjusting for baseline and clustering). Most students (≥90%, n = 2330/2560) from 47 schools received the intervention and had lower depression and suicidal ideation than controls at month 3. Nearly all villages (52/54, 96.2%) provided pesticide lockers (n = 8370 households, 88.83% uptake). Compared with controls, CHWs in the intervention arm had significantly higher knowledge, confidence and skills, and identified 108 at-risk individuals.

Conclusions

The intervention increased identification without significantly reducing suicide attempts, but reduced suicide deaths. This trial, involving 116 villages and a multicomponent intervention implemented at scale, advances suicide prevention and complex intervention research, especially in LMICs.

在低收入和中等收入国家(LMICs),自杀是一个主要问题。大规模自杀预防干预措施的有效性研究有限。目的测试综合干预措施(以学校为基础的预防;减少获得自杀手段的机会;加强对自杀风险的识别和管理)在减少自杀和自杀未遂造成的死亡方面的有效性;并评估子干预措施的实施和有效性。方法在这项实用的整群随机对照试验中,来自印度梅哈萨纳的124个村庄被随机分配到干预组或对照组。干预措施包括以学校为基础的提高认识干预、社区农药储存和培训社区卫生工作者,以识别、支持、转诊和跟进高危人群。意向治疗分析使用混合效应泊松回归检验了主要结果(自杀企图加自杀死亡),多水平线性模型评估了子干预措施。主要结果是通过一种新型自杀监测系统捕获的。结果干预组(62个同意的村庄中有54个)与对照组(62个村庄)的主要结局无统计学差异。另外,干预组显示12个月时自杀死亡风险降低43%(干预组与对照组的自杀率分别为30.7 / 10万人/年和43.6 / 10万人/年;发病率比0.57,95% CI: 0.32-1.02,调整基线和聚类)。来自47所学校的大多数学生(≥90%,n = 2330/2560)接受了干预,在第3个月时抑郁和自杀意念低于对照组。几乎所有村庄(52/54,96.2%)都提供农药储物柜(n = 8370户,使用率为88.83%)。与对照组相比,干预组的卫生保健员的知识、信心和技能显著提高,并识别出108名高危个体。结论干预增加了识别,但没有显著减少自杀企图,但减少了自杀死亡。该试验涉及116个村庄和大规模实施的多成分干预,促进了自杀预防和复杂干预研究,特别是在中低收入国家。
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引用次数: 0
Navigating artificial intelligence's role in suicide prevention: balancing innovation with ethical vigilance. 人工智能在自杀预防中的作用:平衡创新与道德警惕。
Pub Date : 2025-10-29 DOI: 10.1192/bjp.2024.252
Satish Suhas,Guru S Gowda,Krishna Prasad Muliyala,Venkata Senthil Kumar Reddi
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引用次数: 0
Examining the safety profile of clozapine versus other antipsychotics: systematic review and meta-analysis. 检查氯氮平与其他抗精神病药物的安全性:系统回顾和荟萃分析。
Pub Date : 2025-10-28 DOI: 10.1192/bjp.2025.10421
Elisavet Pinioti,Eleni Glarou,Andreas S Lappas,Iwo Fober,Bartosz Helfer,Spyridon Siafis,Nikos Christodoulou,Adriani Nikolakopoulou,Stefan Leucht,Myrto Samara
BACKGROUNDAntipsychotics are first-line treatments for schizophrenia, yet many patients show inadequate response. Clozapine, the gold standard for treatment-resistant schizophrenia, remains underutilised due to safety and monitoring concerns.AIMSTo evaluate the adverse effects of clozapine in schizophrenia through a meta-analysis of randomised controlled trials (RCTs).METHODWe systematically searched MEDLINE, CENTRAL, Embase, PsycINFO, ClinicalTrials.gov and WHO ICTRP up to 10 October 2024 for RCTs comparing clozapine (as either monotherapy or combination therapy) with other antipsychotics. We assessed 37 distinct adverse outcomes. Risk ratios were calculated for dichotomous outcomes and standardised mean differences for continuous outcomes, with confidence intervals.RESULTSA total of 116 RCTs (n = 8431) were included. In 69 monotherapy RCTs (n = 6281), clozapine showed no difference in either mortality (risk ratio 1.01, 95% CI: 0.50, 2.01, prevalence 0.1%) or discontinuation due to adverse effects (risk ratio 1.18, 95% CI: 0.91, 1.53, prevalence 7.2%). Agranulocytosis risk was nearly tripled (risk ratio 2.81, 95% CI: 0.97, 8.12, prevalence 0.7%), although with wide confidence intervals. Clozapine increased the risk of seizures (risk ratio 3.61, 95% CI: 1.80, 7.95, prevalence 3.1%) and orthostatic hypotension/bradycardia/syncope (risk ratio 1.66, 95% CI: 1.00, 2.77, prevalence 11%). No difference was found for myocarditis/cardiomyopathy (risk ratio 0.33, 95% CI: 0.01, 8.13). Clozapine increased the risk of leukopenia, hypersalivation, sedation, tachycardia, hypertension, constipation, nausea/vomiting, fever, flu-like syndrome and headache. In 47 combination RCTs (n = 2150), clozapine combinations were not associated with increased risk of severe adverse effects; no cases of agranulocytosis (21 RCTs, n = 894) or seizures (8 RCTs, n = 313) were reported in trials that explicitly assessed these outcomes.CONCLUSIONSLife-threatening adverse events remain rare with clozapine. With appropriate monitoring, its safety profile supports broader and potentially earlier use. Future studies should refine monitoring protocols and explore additional indications.
背景:抗精神病药物是精神分裂症的一线治疗药物,但许多患者表现出不良反应。氯氮平是治疗难治性精神分裂症的金标准,但由于安全性和监测方面的考虑,氯氮平仍未得到充分利用。目的通过随机对照试验(RCTs)的荟萃分析评估氯氮平对精神分裂症的不良反应。方法系统检索MEDLINE、CENTRAL、Embase、PsycINFO、ClinicalTrials.gov和WHO ICTRP,检索截止到2024年10月10日氯氮平与其他抗精神病药物(单药或联合治疗)比较的随机对照试验。我们评估了37种不同的不良结果。计算二分类结果的风险比,计算连续结果的标准化平均差异,并计算置信区间。结果共纳入116项rct (n = 8431)。在69项单药随机对照试验(n = 6281)中,氯氮平在死亡率(风险比1.01,95% CI: 0.50, 2.01,患病率0.1%)或因不良反应而停药(风险比1.18,95% CI: 0.91, 1.53,患病率7.2%)方面均无差异。粒细胞缺血症的风险几乎增加了两倍(风险比2.81,95% CI: 0.97, 8.12,患病率0.7%),尽管有很宽的置信区间。氯氮平增加癫痫发作(风险比3.61,95% CI: 1.80, 7.95,患病率3.1%)和直立性低血压/心动过缓/晕厥(风险比1.66,95% CI: 1.00, 2.77,患病率11%)的风险。心肌炎/心肌病的风险比无差异(0.33,95% CI: 0.01, 8.13)。氯氮平增加了白细胞减少、唾液过多、镇静、心动过速、高血压、便秘、恶心/呕吐、发烧、流感样综合征和头痛的风险。在47项联合rct (n = 2150)中,氯氮平联合用药与严重不良反应风险增加无关;在明确评估这些结果的试验中,没有粒细胞缺乏症(21项rct, n = 894)或癫痫发作(8项rct, n = 313)的病例报告。结论氯氮平治疗中危及生命的不良事件很少发生。通过适当的监测,其安全性可以支持更广泛和更早的使用。未来的研究应完善监测方案并探索其他适应症。
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引用次数: 0
Structural connectivity of striatal subregions in first-episode schizophrenia: links to positive symptoms and treatment response. 首发精神分裂症纹状体亚区的结构连通性:与阳性症状和治疗反应的联系
Pub Date : 2025-10-24 DOI: 10.1192/bjp.2025.10434
Wenming Liu,Chen Wang,Fan Guo,Min Guo,Runzhu Sun,Kai Yuan,Min Cai,Yuanqiang Zhu
BACKGROUNDSchizophrenia is a severe psychiatric disorder characterised by positive symptoms, such as hallucinations and delusions, which are linked to dysregulated striatal connectivity. Although traditional models highlight the limbic striatum's role in salience processing, emerging evidence suggests that the associative striatum, critical for cognitive control and habit formation, also plays a significant role. However, the structural connectivity underlying striatal subregions and its relationship to symptom severity and treatment response remains poorly understood.AIMSThis study aimed to investigate the structural connectivity of striatal subregions in first-episode schizophrenia (FE-SCZ) patients and to evaluate its association with positive symptoms and changes following antipsychotic treatment.METHODWe recruited 80 FE-SCZ patients and 80 healthy controls who underwent diffusion tensor imaging probabilistic tractography to assess white matter tract strength between the striatum and ten cortical targets. Longitudinal analysis was conducted in patients at baseline (within 2 weeks of initial antipsychotic exposure) and after ongoing treatment to evaluate changes in connectivity and their relationship to symptom improvement.RESULTSFE-SCZ patients exhibited reduced connectivity between the dorsolateral prefrontal cortex (dlPFC) and associative striatum and increased connectivity between the anterior cingulate cortex (ACC) and associative striatum compared to controls. Longitudinal analysis revealed that antipsychotic treatment increased dlPFC-associative striatum connectivity and decreased ACC-associative striatum connectivity, which correlated with reductions in positive symptom severity.CONCLUSIONSThese findings highlight the critical role of striatal subregions in the pathophysiology of schizophrenia, emphasising the associative striatum's involvement in cognitive control and salience attribution. Changes in striatal connectivity after continued antipsychotic therapy may serve as a biomarker for symptom improvement, advancing our understanding of schizophrenia and guiding future therapeutic strategies.
精神分裂症是一种严重的精神疾病,其特征是阳性症状,如幻觉和妄想,这些症状与纹状体连接失调有关。尽管传统模型强调边缘纹状体在显著性处理中的作用,但新出现的证据表明,对认知控制和习惯形成至关重要的联想纹状体也起着重要作用。然而,纹状体亚区的结构连通性及其与症状严重程度和治疗反应的关系仍然知之甚少。目的:研究首发精神分裂症(FE-SCZ)患者纹状体亚区的结构连通性,并评估其与阳性症状和抗精神病药物治疗后的变化的关系。方法选取80例FE-SCZ患者和80例健康对照,采用弥散张量成像概率束造影评估纹状体与10个皮层靶点之间的白质束强度。对基线(初始抗精神病药物暴露2周内)和持续治疗后的患者进行纵向分析,以评估连通性的变化及其与症状改善的关系。结果与对照组相比,tsfe - scz患者表现出背外侧前额叶皮层(dlPFC)与联想纹状体之间的连通性降低,前扣带皮层(ACC)与联想纹状体之间的连通性增加。纵向分析显示,抗精神病药物治疗增加了dlpfc相关纹状体的连通性,降低了acc相关纹状体的连通性,这与阳性症状严重程度的降低相关。结论这些发现强调了纹状体亚区在精神分裂症病理生理中的关键作用,强调了联想纹状体在认知控制和显著性归因中的参与。持续抗精神病药物治疗后纹状体连通性的变化可能作为症状改善的生物标志物,促进我们对精神分裂症的理解并指导未来的治疗策略。
{"title":"Structural connectivity of striatal subregions in first-episode schizophrenia: links to positive symptoms and treatment response.","authors":"Wenming Liu,Chen Wang,Fan Guo,Min Guo,Runzhu Sun,Kai Yuan,Min Cai,Yuanqiang Zhu","doi":"10.1192/bjp.2025.10434","DOIUrl":"https://doi.org/10.1192/bjp.2025.10434","url":null,"abstract":"BACKGROUNDSchizophrenia is a severe psychiatric disorder characterised by positive symptoms, such as hallucinations and delusions, which are linked to dysregulated striatal connectivity. Although traditional models highlight the limbic striatum's role in salience processing, emerging evidence suggests that the associative striatum, critical for cognitive control and habit formation, also plays a significant role. However, the structural connectivity underlying striatal subregions and its relationship to symptom severity and treatment response remains poorly understood.AIMSThis study aimed to investigate the structural connectivity of striatal subregions in first-episode schizophrenia (FE-SCZ) patients and to evaluate its association with positive symptoms and changes following antipsychotic treatment.METHODWe recruited 80 FE-SCZ patients and 80 healthy controls who underwent diffusion tensor imaging probabilistic tractography to assess white matter tract strength between the striatum and ten cortical targets. Longitudinal analysis was conducted in patients at baseline (within 2 weeks of initial antipsychotic exposure) and after ongoing treatment to evaluate changes in connectivity and their relationship to symptom improvement.RESULTSFE-SCZ patients exhibited reduced connectivity between the dorsolateral prefrontal cortex (dlPFC) and associative striatum and increased connectivity between the anterior cingulate cortex (ACC) and associative striatum compared to controls. Longitudinal analysis revealed that antipsychotic treatment increased dlPFC-associative striatum connectivity and decreased ACC-associative striatum connectivity, which correlated with reductions in positive symptom severity.CONCLUSIONSThese findings highlight the critical role of striatal subregions in the pathophysiology of schizophrenia, emphasising the associative striatum's involvement in cognitive control and salience attribution. Changes in striatal connectivity after continued antipsychotic therapy may serve as a biomarker for symptom improvement, advancing our understanding of schizophrenia and guiding future therapeutic strategies.","PeriodicalId":22495,"journal":{"name":"The British Journal of Psychiatry","volume":"50 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trajectories of depression across key events in later life: findings from the English Longitudinal Study of Ageing. 抑郁在晚年生活中贯穿关键事件的轨迹:来自英国老龄化纵向研究的发现。
Pub Date : 2025-10-24 DOI: 10.1192/bjp.2025.10426
Brian Beach,Eun-Jung Shim,Eleonora Iob,Paola Zaninotto
BACKGROUNDVarious key events characterise experiences in later life, such as retirement, bereavement, caregiving, developing long-term conditions and hospital admission. Given their potential to disrupt lives, such events may affect older people's mental health, but research on the associations between such events and depression has produced inconsistent findings.AIMSTo investigate the impact of key events in later life on depression trajectories in a representative cohort of people aged 50-69 in England.METHODOur sample draws on 6890 respondents aged 50-69 in Wave 1 (2002/2003) of the English Longitudinal Study of Ageing, following them through to Wave 9 (2018/2019). We measured depression using the eight-item Center for Epidemiological Studies Depression scale. Later life events included retirement, spouse/partner death, becoming an unpaid caregiver, developing a limiting long-term illness and hospital admissions because of a fall or non-fall causes. Piecewise mixed-effects logistic regression models tested for changes in the trajectories of depression before and after each event.RESULTSStatistically significant improvements in the trajectory of depression were observed following spousal bereavement, one's own retirement and hospital admission because of causes other than falls, with reductions in the odds of depression of 48% (odds ratio: 0.52 (95% CI: 0.44-0.61)), 15% (0.85 (0.78-0.92)) and 4% (0.96 (0.94-0.99)), respectively. No changes were associated with developing a limiting long-term illness, becoming an unpaid caregiver or following spousal retirement or a hospital admission because of a fall.CONCLUSIONSThe findings highlight the relative resilience among older adults in England in terms of depression following key later life events. There is still a role to play in delivering mental health support for older people following such events, particularly by improving the identification of those at risk of certain events as part of a broader strategy of prevention. Findings also underscore the importance of partner/spousal circumstances on individual mental health.
各种各样的关键事件是晚年生活的特征,如退休、丧亲、照顾、发展长期疾病和住院。鉴于这些事件有可能扰乱生活,它们可能会影响老年人的心理健康,但对这些事件与抑郁症之间关系的研究得出了不一致的结果。目的研究英国50-69岁人群中晚年生活中关键事件对抑郁轨迹的影响。我们的样本抽取了英国老龄化纵向研究第1波(2002/2003)中6890名年龄在50-69岁之间的受访者,并跟随他们进入第9波(2018/2019)。我们使用八项流行病学研究中心抑郁量表来测量抑郁症。晚年生活事件包括退休、配偶/伴侣死亡、成为无薪照顾者、患上限制性长期疾病以及因跌倒或非跌倒原因住院。分段混合效应逻辑回归模型测试了每次事件前后抑郁轨迹的变化。结果在配偶丧偶、自己退休和因跌倒以外的原因入院后,抑郁症的发展轨迹有统计学上的显著改善,抑郁的几率分别降低48%(优势比:0.52 (95% CI: 0.44-0.61))、15%(0.85(0.78-0.92))和4%(0.96(0.94-0.99))。没有变化与患上限制性长期疾病、成为无薪照顾者、配偶退休或因跌倒住院有关。结论:该研究结果强调了英格兰老年人在晚年生活中的关键事件后抑郁的相对恢复能力。在这类事件发生后,在向老年人提供心理健康支持方面仍可发挥作用,特别是通过作为更广泛的预防战略的一部分,改进对面临某些事件风险的人的识别。调查结果还强调了伴侣/配偶环境对个人心理健康的重要性。
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引用次数: 0
Self-harm in children and young people who die by suicide: UK-wide consecutive case series: commentary, McKean et al. 自杀身亡的儿童和青少年的自我伤害:英国范围内的连续病例系列:评论,McKean等。
Pub Date : 2025-10-23 DOI: 10.1192/bjp.2025.10449
Alastair J S McKean,Tanner J Bommersbach,J Michael Bostwick
{"title":"Self-harm in children and young people who die by suicide: UK-wide consecutive case series: commentary, McKean et al.","authors":"Alastair J S McKean,Tanner J Bommersbach,J Michael Bostwick","doi":"10.1192/bjp.2025.10449","DOIUrl":"https://doi.org/10.1192/bjp.2025.10449","url":null,"abstract":"","PeriodicalId":22495,"journal":{"name":"The British Journal of Psychiatry","volume":"15 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the risk: predicting out-of-hospital cardiac arrest in geriatric patients with depression - longitudinal study. 揭示风险:预测老年抑郁症患者院外心脏骤停-纵向研究。
Pub Date : 2025-10-23 DOI: 10.1192/bjp.2025.10427
Chih-Wei Sung,Cheng-Che Chen,Yun-Ting Chih,Cheng-Yi Fan,Edward Pei-Chuan Huang
BACKGROUNDThe association between geriatric depression and out-of-hospital cardiac arrest (OHCA) has not been fully clarified.AIMSThis study aimed to develop and validate a predictive model for OHCA in older patients through a longitudinal, population-based approach.METHODThis study analysed data from the National Health Insurance Research Database for the period 2011-2020, focusing on older patients both diagnosed with depression and treated with antidepressant medications. A multivariate logistic regression model was used to identify potential predictors of OHCA. Considering the effect of COVID-19, data-sets from 2019 and 2020 were used as external validation. The model's performance was evaluated using receiver operating characteristic (ROC) curves and confusion matrix metrics.RESULTSOut of 104 022 geriatric patients with depression, 2479 (2.4%) experienced OHCA. Significant predictors of OHCA included age, male gender, previous utilisation of medical resources, renal failure with haemodialysis, existing comorbidities, medication changes and recent psychotherapy. The ROC values for the predictive models ranged from 0.707 to 0.771 in the 2019 and 2020 external validations for 7-, 30- and 90-day OHCA. For 2019, the 7-day model demonstrated sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of 0.600, 0.718, 2.130, 0.560 and 3.840, respectively. For 2020, these metrics for the 7-day model were 0.775, 0.655, 2.250, 0.340 and 6.550, respectively.CONCLUSIONThis study developed and validated a predictive model for OHCA in older patients with depression. The model identified crucial predictors, providing valuable insights for psychiatrists and emergency clinicians to identify high-risk patients and implement early preventive measures.
背景:老年抑郁症与院外心脏骤停(OHCA)之间的关系尚未完全明确。目的:本研究旨在通过纵向、基于人群的方法,开发和验证老年患者OHCA的预测模型。方法本研究分析了2011-2020年国家健康保险研究数据库的数据,重点关注诊断为抑郁症并接受抗抑郁药物治疗的老年患者。采用多变量logistic回归模型确定OHCA的潜在预测因素。考虑到COVID-19的影响,使用2019年和2020年的数据集作为外部验证。使用受试者工作特征(ROC)曲线和混淆矩阵指标评估模型的性能。结果104022例老年抑郁症患者中,有2479例(2.4%)出现过OHCA。OHCA的重要预测因素包括年龄、男性性别、既往医疗资源利用情况、血液透析肾衰竭、现有合并症、药物变化和最近的心理治疗。在2019年和2020年对7天、30天和90天的OHCA进行的外部验证中,预测模型的ROC值范围为0.707至0.771。2019年,7天模型的敏感性、特异性、阳性似然比、阴性似然比和诊断优势比分别为0.600、0.718、2.130、0.560和3.840。对于2020年,7天模型的这些指标分别为0.775、0.655、2.250、0.340和6.550。结论:本研究建立并验证了老年抑郁症患者OHCA的预测模型。该模型确定了关键的预测因素,为精神科医生和急诊临床医生识别高风险患者和实施早期预防措施提供了有价值的见解。
{"title":"Unveiling the risk: predicting out-of-hospital cardiac arrest in geriatric patients with depression - longitudinal study.","authors":"Chih-Wei Sung,Cheng-Che Chen,Yun-Ting Chih,Cheng-Yi Fan,Edward Pei-Chuan Huang","doi":"10.1192/bjp.2025.10427","DOIUrl":"https://doi.org/10.1192/bjp.2025.10427","url":null,"abstract":"BACKGROUNDThe association between geriatric depression and out-of-hospital cardiac arrest (OHCA) has not been fully clarified.AIMSThis study aimed to develop and validate a predictive model for OHCA in older patients through a longitudinal, population-based approach.METHODThis study analysed data from the National Health Insurance Research Database for the period 2011-2020, focusing on older patients both diagnosed with depression and treated with antidepressant medications. A multivariate logistic regression model was used to identify potential predictors of OHCA. Considering the effect of COVID-19, data-sets from 2019 and 2020 were used as external validation. The model's performance was evaluated using receiver operating characteristic (ROC) curves and confusion matrix metrics.RESULTSOut of 104 022 geriatric patients with depression, 2479 (2.4%) experienced OHCA. Significant predictors of OHCA included age, male gender, previous utilisation of medical resources, renal failure with haemodialysis, existing comorbidities, medication changes and recent psychotherapy. The ROC values for the predictive models ranged from 0.707 to 0.771 in the 2019 and 2020 external validations for 7-, 30- and 90-day OHCA. For 2019, the 7-day model demonstrated sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of 0.600, 0.718, 2.130, 0.560 and 3.840, respectively. For 2020, these metrics for the 7-day model were 0.775, 0.655, 2.250, 0.340 and 6.550, respectively.CONCLUSIONThis study developed and validated a predictive model for OHCA in older patients with depression. The model identified crucial predictors, providing valuable insights for psychiatrists and emergency clinicians to identify high-risk patients and implement early preventive measures.","PeriodicalId":22495,"journal":{"name":"The British Journal of Psychiatry","volume":"28 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary censors at work: targeting medical science to shape social reality. 当代审查员的工作:以医学为目标塑造社会现实。
Pub Date : 2025-10-22 DOI: 10.1192/bjp.2025.10459
Astrid Chevance
Censoring language in medical science enforces ideological conformity and political repression of marginalised groups through self-censorship. This editorial urges the scientific community to resist language control as a grave threat - not only to research freedom, but ultimately to human diversity and life itself.
医学领域的语言审查通过自我审查加强了对边缘群体的意识形态一致性和政治压制。这篇社论敦促科学界抵制语言控制,因为它不仅是对研究自由的严重威胁,而且最终是对人类多样性和生命本身的威胁。
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引用次数: 0
期刊
The British Journal of Psychiatry
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