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AI-Driven CT-MRI Image Fusion and Segmentation for Automatic Preoperative Planning of ACL Reconstruction: Development and Application. ai驱动的CT-MRI图像融合与分割在ACL重建术前自动规划中的发展与应用。
Pub Date : 2025-12-09 DOI: 10.2106/jbjs.25.00485
Haomiao Yu,Jixiang Dong,Long Wang,Haipeng Li,Mingxin Wang,Yaoting Wang,Yibo Li,Yong Yang,Yi Ge,Yafang Zhang,Xingyu Liu,Qi Yao,Ai Guo,Yiling Zhang,Chunbao Li
BACKGROUNDThe goals of this study were to develop an artificial intelligence (AI)-driven automated preoperative planning system for anterior cruciate ligament (ACL) reconstruction by integrating deep learning with computed tomography (CT)-magnetic resonance imaging (MRI) image fusion and segmentation, and to evaluate its accuracy.METHODSStructures on CT and MRI scans of 200 knee joints from patients with an intact ACL (aged 18 to 50 years, 81.0% male, all ethnic Chinese) were manually annotated. Fusion of the CT and MRI images was performed using a Dual-UNet registration architecture incorporating multiscale information fusion, enabling dynamic 3D reconstruction of the fused images for ACL insertion site identification and isometry assessment. A deep-learning framework was trained to analyze the fused image to precisely optimize ACL tunnel positioning, including identifying the entrances and exits of the femoral and tibial tunnels. Criteria in the automated planning included proximity to the ideal point, coverage of the anatomical footprint area, and isometric length variation of <2 mm. The accuracy of the AI system was then validated in 36 ACL reconstructions performed in bone models by comparing the drilled femoral and tibial tunnel lengths and graft length between the tunnels with the planned values. Finally, clinical feasibility was tested in 36 patients undergoing ACL reconstruction surgery using 3D-printed patient-specific guides derived from the AI planning, with 36 conventional surgeries as controls. Deviation of tunnel positions from the planned positions was compared between the 2 groups.RESULTSCT-MRI image fusion was able to generate an individualized 3D model with high segmentation accuracy (Dice coefficient = 0.864). The AI planning required 192 ± 90.2 seconds per case. In the bone model validation, the mean deviation between the planned and executed values was <1 mm for the femoral and tibial tunnel lengths and graft length between the tunnels (all p > 0.05). In the clinical testing, the AI-guided group demonstrated significantly smaller deviations from the ideal point compared with the conventional group in the deep-to-shallow (D-S), high-to-low (H-L), medial-to-lateral (M-L), and anterior-to-posterior (A-P) directions (all p < 0.05).CONCLUSIONSThe AI-driven segmentation of CT-MRI fusion images and automatic preoperative ACL reconstruction planning demonstrated the capability to automatically, precisely, and reproducibly generate plans for nearly ideal tunnel entry and exit points with isometric, anatomical, and individualization characteristics. This technology is expected to hold clinical potential for ACL reconstruction, including reduced complication and revision rates and enhanced postoperative function.
本研究的目的是通过将深度学习与计算机断层扫描(CT)-磁共振成像(MRI)图像融合和分割相结合,开发人工智能(AI)驱动的前交叉韧带(ACL)重建自动化术前规划系统,并评估其准确性。方法对200例完整前交叉韧带患者(年龄18 ~ 50岁,男性81.0%,华人)的膝关节CT和MRI扫描结构进行人工注释。使用包含多尺度信息融合的Dual-UNet配准架构对CT和MRI图像进行融合,实现融合图像的动态3D重建,用于ACL插入位置识别和等距评估。训练深度学习框架来分析融合图像以精确优化ACL隧道定位,包括识别股骨和胫骨隧道的入口和出口。自动规划的标准包括接近理想点,覆盖解剖足迹区域,等距长度变化0.05)。在临床试验中,人工智能引导组在深到浅(D-S)、高到低(H-L)、中到外侧(M-L)、前到后(A-P)方向与理想点的偏差均明显小于常规组(p < 0.05)。结论人工智能驱动的CT-MRI融合图像分割和ACL术前自动重建规划显示,能够自动、精确和可重复地生成具有等距、解剖和个性化特征的接近理想的隧道入口和出口点的规划。该技术有望在ACL重建中具有临床潜力,包括减少并发症和翻修率以及增强术后功能。
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引用次数: 0
To Debride or Not to Debride-That Was the Question: Commentary on an article by Leslie Bisson, MD, et al.: "Debridement of Unstable Chondral Lesions During Arthroscopic Partial Meniscectomy Provides No Long-Term Benefit. Patient Outcomes 9 Years After the Original ChAMP Trial". 清创还是不清创——这是一个问题:对Leslie Bisson, MD等人的一篇文章的评论:“关节镜下半月板部分切除术中不稳定软骨病变的清创没有长期益处。”原ChAMP试验9年后的患者结果”。
Pub Date : 2025-12-03 DOI: 10.2106/jbjs.25.00502
Tyler M Hauer,Craig S Mauro
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引用次数: 0
Physical Activity and 4-Year Radiographic Medial Joint Space Loss in Knee Osteoarthritis: A Joint Model Analysis. 膝关节骨性关节炎的身体活动和4年的x线片内侧关节间隙损失:关节模型分析。
Pub Date : 2025-12-03 DOI: 10.2106/jbjs.25.00656
Qianying Cai,Hao Peng,Vicky Duong,Win Min Oo,Youshui Gao,Yong Feng,Changqing Zhang,Liubov Arbeeva,Daniel K White,David J Hunter,Kai Fu
BACKGROUNDWe examined the association between physical activity (PA) and joint space loss (JSL) over 48 months in individuals with knee osteoarthritis to assess the role of the PA level in knee osteoarthritis progression.METHODSWe analyzed 1,806 participants from the Osteoarthritis Initiative. PA was measured with the Physical Activity Scale for the Elderly (PASE) and was categorized as low, moderate, or high. JSL was defined as a reduction in joint space width of ≥0.7 mm. Analyses were stratified by the baseline Kellgren-Lawrence (KL) grade. Cox proportional-hazards (CoxPH) and joint models assessed the association between baseline PA and changes in longitudinal PA and JSL, adjusting for covariates.RESULTSOver 48 months, 33.8% of the patients experienced JSL. In patients with KL grade 2, the moderate PA tertile was associated with a reduced JSL risk compared with low PA in both standard and marginal CoxPH analyses. However, in patients with KL grade 3, increasing PA in the continuous PASE modeling was associated with increased JSL risk (marginal CoxPH: hazard ratio [HR], 1.002 [95% confidence interval (CI), 1.001 to 1.004]), confirmed by joint models (HR, 1.083 [95% CI, 1.020 to 1.150]). The rate of change of PA over time did not significantly influence progression.CONCLUSIONSModerate or high PA did not increase the 4-year JSL risk in patients with KL grade 2. However, higher current PA was associated with higher JSL risk in patients with KL grade 3, highlighting the need for further research on the complex impact of PA on osteoarthritis. These findings may help clinicians to identify patient subgroups who could benefit from tailored PA recommendations, informing value-based care and personalized osteoarthritis management.LEVEL OF EVIDENCEPrognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
研究背景:我们研究了膝关节骨性关节炎患者48个月内身体活动(PA)与关节间隙损失(JSL)之间的关系,以评估PA水平在膝关节骨性关节炎进展中的作用。方法:我们分析了来自骨关节炎倡议的1806名参与者。PA用老年人体力活动量表(PASE)测量,分为低、中、高三个等级。JSL定义为关节间隙宽度减小≥0.7 mm。以基线Kellgren-Lawrence (KL)分级对分析进行分层。Cox比例风险(Cox proportional-hazards, Cox - ph)和联合模型评估了基线PA与纵向PA和JSL变化之间的关系,并对协变量进行了调整。结果48个月内,33.8%的患者出现JSL。在KL 2级患者中,在标准和边际cox - ph分析中,与低PA相比,中度PA与降低JSL风险相关。然而,在KL 3级患者中,连续PASE模型中PA增加与JSL风险增加相关(边际cox:危险比[HR], 1.002[95%置信区间(CI), 1.001至1.004]),联合模型证实了这一点(HR, 1.083 [95% CI, 1.020至1.150])。PA随时间的变化率对病情进展没有显著影响。结论:中度或高PA不增加2级KL患者4年JSL风险。然而,在KL 3级患者中,较高的电流PA与较高的JSL风险相关,这表明需要进一步研究PA对骨关节炎的复杂影响。这些发现可能有助于临床医生确定可以从定制PA建议中受益的患者亚组,为基于价值的护理和个性化骨关节炎管理提供信息。证据水平:预后III级。有关证据水平的完整描述,请参见作者说明。
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引用次数: 0
Helical Blade or Lag Screw? It Doesn't Matter as Much as We Thought: Commentary on an article by Kanu Okike, MD, MPH, et al.: "Helical Blade Versus Lag Screw Fixation in the Cephalomedullary Nailing of Geriatric Hip Fractures". 螺旋刀片还是拉力螺钉?这并不像我们想象的那么重要:对Kanu Okike, MD, MPH等人的一篇文章的评论:“螺旋刀片与拉力螺钉固定治疗老年髋部骨折的头髓内钉”。
Pub Date : 2025-12-03 DOI: 10.2106/jbjs.25.01046
Sean T Campbell
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引用次数: 0
Obligate Posterosuperior Humeral Head Translation Following the Latarjet Procedure Demonstrates That Its Triple Blocking Effect Is Real: Commentary on an article by Josephine Olsen Kipp, MD, PhD, et al.: "The Latarjet Procedure May Induce Pathokinematics with Posterior Humeral Head Subluxation. An Experimental Dynamic Radiostereometric Study". Latarjet手术后肱骨后上位移位证明其三重阻断作用是真实存在的:对Josephine Olsen Kipp, MD, PhD等人的一篇文章的评论:“Latarjet手术可能导致肱骨后头半脱位的病理运动学。实验动态放射立体学研究”。
Pub Date : 2025-12-03 DOI: 10.2106/jbjs.25.01091
Samer S Hasan
{"title":"Obligate Posterosuperior Humeral Head Translation Following the Latarjet Procedure Demonstrates That Its Triple Blocking Effect Is Real: Commentary on an article by Josephine Olsen Kipp, MD, PhD, et al.: \"The Latarjet Procedure May Induce Pathokinematics with Posterior Humeral Head Subluxation. An Experimental Dynamic Radiostereometric Study\".","authors":"Samer S Hasan","doi":"10.2106/jbjs.25.01091","DOIUrl":"https://doi.org/10.2106/jbjs.25.01091","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"30 1","pages":"2594-2595"},"PeriodicalIF":0.0,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145663946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sacral Insufficiency Fractures: Pathology, Management, and Outcomes. 骶骨功能不全骨折:病理、处理和结果。
Pub Date : 2025-12-03 DOI: 10.2106/jbjs.25.00482
Andrew P Collins,Erika Roddy,William T Davis,Reza Firoozabadi
➢ Sacral insufficiency fractures are associated with high morbidity and mortality rates and are becoming increasingly prevalent in elderly patients with osteoporosis.➢ Prompt identification of these injuries and appropriate treatment for stable and unstable fractures can reduce patient morbidity.➢ The treatment of sacral insufficiency fractures depends on the severity of symptoms, which, in most cases, is associated with the degree of fracture instability. Treatment options include nonoperative measures, pharmacologic therapies, procedural treatments, and operative management.➢ Sacroplasty may be an effective procedural treatment for sacral insufficiency fractures, although there has been a lack of comparative studies, and complication types and rates are concerning.➢ Percutaneous posterior pelvic ring screws demonstrate stable fixation, allowing early patient mobilization. Standard posterior pelvic ring percutaneous fixation has high screw backout rates, although new implants may mitigate these complications.➢ There have been limited comparative data on outcomes following treatment of these injuries across procedural and operative techniques.
骶骨不全骨折具有较高的发病率和死亡率,在老年骨质疏松患者中越来越普遍。(四)及时识别这些损伤,对稳定型和不稳定型骨折进行适当治疗,可降低患者发病率。(四)骶骨功能不全骨折的治疗取决于症状的严重程度,多数情况下与骨折不稳定程度有关。治疗方案包括非手术措施、药物治疗、程序治疗和手术管理。目前尚缺乏相关的比较研究,且并发症的类型和发生率值得关注,但目前寰椎移植术可能是治疗骶骨功能不全骨折的有效方法。经皮盆腔后环螺钉固定稳定,可使患者早期活动。标准骨盆后环经皮内固定螺钉退位率高,但新植入物可减轻这些并发症。(五)关于这些损伤在手术和程序技术治疗后的结果的比较数据有限。
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引用次数: 0
Excessive Laxity as an Indicator for a Secondary Procedure to Protect Posterior Cruciate Ligament Reconstruction: Is the Juice Worth the Squeeze?: Commentary on an article by Kyoung Ho Yoon, MD, PhD, et al.: "Posterior Cruciate Ligament (PCL) Versus Combined PCL and Posterolateral Corner Reconstruction in Isolated PCL Grade-III Injuries". 过度松弛作为二次手术保护后交叉韧带重建的指标:果汁值得挤压吗?:对Kyoung Ho Yoon, MD, PhD等人的一篇文章的评论:“后十字韧带(PCL)与联合PCL和后外侧角重建治疗孤立的PCL iii级损伤”。
Pub Date : 2025-12-03 DOI: 10.2106/jbjs.25.01233
John A Grant
{"title":"Excessive Laxity as an Indicator for a Secondary Procedure to Protect Posterior Cruciate Ligament Reconstruction: Is the Juice Worth the Squeeze?: Commentary on an article by Kyoung Ho Yoon, MD, PhD, et al.: \"Posterior Cruciate Ligament (PCL) Versus Combined PCL and Posterolateral Corner Reconstruction in Isolated PCL Grade-III Injuries\".","authors":"John A Grant","doi":"10.2106/jbjs.25.01233","DOIUrl":"https://doi.org/10.2106/jbjs.25.01233","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"157 1","pages":"2591-2592"},"PeriodicalIF":0.0,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145663949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bracing Outcomes and Risk of Curve Progression in Adolescents with Idiopathic Scoliosis and Autism Spectrum Disorder. 青少年特发性脊柱侧凸和自闭症谱系障碍患者的支具结局和弯曲进展风险。
Pub Date : 2025-12-03 DOI: 10.2106/jbjs.25.00668
Jason Zarahi Amaral,Antony Kallur,Lori A Dolan,Austin Q Nguyen,Rebecca J Schultz,Benjamin M Martin,Pablo Coello,Jacob P Scioscia,Barkha N Chhabra,Darrell S Hanson,Frank T Gerow,Brian G Smith
BACKGROUNDWhether the sensory and behavioral traits of autism spectrum disorder (ASD) affect bracing outcomes in adolescent idiopathic scoliosis (AIS) remains unclear. This study evaluated the impact of ASD on bracing success, curve progression, and patient-reported outcomes in patients with AIS.METHODSThis retrospective study included patients 10 to 18 years of age who were treated for AIS with bracing between 2011 and 2024. A total of 58 patients with ASD were matched in a 1:2 ratio to 116 controls with use of nearest-neighbor matching based on BrAIST-Calc predicted probabilities. Exclusions included non-idiopathic scoliosis, early-onset scoliosis, kyphoscoliosis, a Risser stage of >2, pre-treatment curves of <25° or >40°, and inadequate follow-up. Progression to the surgical threshold was defined as a major curve of ≥45°. Firth logistic regression was used to model the association between ASD and progression to the surgical threshold, adjusting for residual imbalances.RESULTSThe matched cohort (n = 174; 51% male; 40% White, 25% Hispanic, 21% Black, 10% Asian, and 5% not specified) demonstrated balanced propensity scores (SMD = 0.006). Compared with patients without ASD, those with ASD had higher rates of progression to the surgical threshold (40% versus 20%; p = 0.005), a curve progression of ≥6° (60% versus 38%; p = 0.005), noncompliance (36% versus 22%; p = 0.04), brace-related issues (22% versus 8%; p = 0.006), and surgery being recommended or performed (33% versus 13%; p = 0.002). In the multivariable analysis, ASD (odds ratio [OR], 3.12 [95% confidence interval (CI), 1.32 to 7.35]; p = 0.009), noncompliance (OR, 4.00 [95% CI, 1.65 to 9.71]; p = 0.002), and a greater initial curve magnitude (OR per degree, 1.26 [95% CI, 1.15 to 1.38]; p < 0.001) significantly increased the odds of progression to the surgical threshold. Within the ASD group, Scoliosis Research Society-22 revised (SRS-22r) self-image, management, and total scores improved significantly over time. No significant between-group differences in change scores were observed.CONCLUSIONSAdolescents with ASD were >3 times more likely to progress to the surgical threshold and had higher rates of noncompliance, brace-related issues, and surgery being recommended or performed. ASD may represent a risk factor for bracing failure, potentially related to sensory or behavioral intolerance. Nonetheless, 60% of patients with ASD avoided progression to the surgical threshold, and within-group improvements in SRS-22r scores were observed. These findings support bracing as a viable treatment option for patients with ASD, although it is likely best paired with individualized care and closer follow-up. Future studies should aim to improve brace tolerance and adherence in this population.LEVEL OF EVIDENCETherapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
背景自闭症谱系障碍(ASD)的感觉和行为特征是否影响青少年特发性脊柱侧凸(AIS)的支具效果尚不清楚。本研究评估了ASD对AIS患者支具成功、曲度进展和患者报告结果的影响。方法本回顾性研究纳入2011年至2024年间接受AIS支架治疗的10 - 18岁患者。使用基于brist - calc预测概率的最近邻匹配,以1:2的比例对58名ASD患者与116名对照组进行匹配。排除包括非特发性脊柱侧凸、早发性脊柱侧凸、后凸性脊柱侧凸、bbbb2的Risser期、治疗前曲线为40°和随访不充分。进展到手术阈值被定义为≥45°的主曲线。第五,逻辑回归用于模拟ASD与进展到手术阈值之间的关系,调整残余不平衡。结果匹配的队列(n = 174, 51%男性,40%白人,25%西班牙裔,21%黑人,10%亚洲人,5%未指定)显示平衡倾向得分(SMD = 0.006)。与没有ASD的患者相比,ASD患者进展到手术阈值的比率更高(40%对20%,p = 0.005),曲线进展≥6°(60%对38%,p = 0.005),不依从性(36%对22%,p = 0.04),支架相关问题(22%对8%,p = 0.006),以及推荐或实施手术(33%对13%,p = 0.002)。在多变量分析中,ASD(优势比[OR], 3.12[95%可信区间(CI), 1.32 ~ 7.35];p = 0.009)、不依从性(OR, 4.00 [95% CI, 1.65至9.71];p = 0.002)和较大的初始曲线幅度(OR每度,1.26 [95% CI, 1.15至1.38];p < 0.001)显著增加进展到手术阈值的几率。在ASD组中,脊柱侧凸研究协会-22修订(SRS-22r)的自我形象、管理和总分随着时间的推移显著改善。组间变化评分无显著差异。结论:青少年ASD进展到手术阈值的可能性是青少年ASD患者的3倍,不依从性、牙套相关问题以及推荐或实施手术的比例更高。ASD可能是支具失效的一个危险因素,可能与感觉或行为不耐受有关。尽管如此,60%的ASD患者避免了进展到手术阈值,并且观察到组内SRS-22r评分的改善。这些发现支持支具作为ASD患者可行的治疗选择,尽管它可能最好与个性化护理和更密切的随访相结合。未来的研究应旨在提高这一人群的支具耐受性和依从性。证据水平:治疗性三级。有关证据水平的完整描述,请参见作者说明。
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引用次数: 0
Fractures of the Femur After Hip Joint Replacement: The Vancouver Classification After 30 Years. 髋关节置换术后股骨骨折:30年后的温哥华分类。
Pub Date : 2025-12-02 DOI: 10.2106/jbjs.25.00336
Clive P Duncan,Bassam A Masri
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引用次数: 0
When Half of Humanity Is Invisible: Reflections on the Erasure of Female Surgeons. 当人类的一半是隐形的:对女外科医生消失的思考。
Pub Date : 2025-11-26 DOI: 10.2106/jbjs.25.00108
Agathe Yvinou
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引用次数: 0
期刊
The Journal of Bone & Joint Surgery
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