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A Second Trauma: Navigating Infection After Orthopaedic Surgery. 第二次创伤:骨科手术后的感染导航。
Pub Date : 2025-11-19 DOI: 10.2106/jbjs.25.00921
Debra Marvel,Jodi L Gallant,Sarah MacRae,Sheila Sprague
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引用次数: 0
Objective Ignorance: A Flaw in Our Ability to Predict Patient Outcomes. 客观无知:我们预测病人预后能力的缺陷。
Pub Date : 2025-11-19 DOI: 10.2106/jbjs.25.00638
Frederick A Matsen
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引用次数: 0
Open Fractures: Still Risky After All These Years: Commentary on an article by Roman M. Natoli, MD, PhD, et al.: "Infection and Nonunion Rates in Open Fractures. Description of 6,042 Fractures from the FLOW and PREP-IT Trials". 开放性骨折:多年后仍有风险:对Roman M. Natoli, MD, PhD等文章的评论:“开放性骨折的感染和不愈合率。来自FLOW和PREP-IT试验的6042条裂缝描述”。
Pub Date : 2025-11-19 DOI: 10.2106/jbjs.25.00175
Thomas A DeCoster
{"title":"Open Fractures: Still Risky After All These Years: Commentary on an article by Roman M. Natoli, MD, PhD, et al.: \"Infection and Nonunion Rates in Open Fractures. Description of 6,042 Fractures from the FLOW and PREP-IT Trials\".","authors":"Thomas A DeCoster","doi":"10.2106/jbjs.25.00175","DOIUrl":"https://doi.org/10.2106/jbjs.25.00175","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"31 1","pages":"2488-2489"},"PeriodicalIF":0.0,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145613382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global Perspectives on the Management of Periprosthetic Joint Infection. 假体周围关节感染处理的全球视角。
Pub Date : 2025-11-19 DOI: 10.2106/jbjs.25.00775
Nicolas S Piuzzi,Irene K Sigmund,Pablo A Slullitel,Nicolaas Budhiparama,Laurens Manning,Anabelle Visperas,Javad Parvizi
➢ The rate of periprosthetic joint infection (PJI) is rising globally, with substantial regional variability, and PJI has 5-year mortality rates of 15% to 25%, which exceed those of early-stage breast and prostate cancer and rival those of colorectal and hematologic malignancies.➢ Diagnostic criteria, including synovial fluid analysis, novel culture techniques, and molecular techniques, have improved in accuracy. However, infections caused by fastidious, biofilm-forming microorganisms continue to pose a major diagnostic challenge worldwide.➢ While patient selection remains critical for successful outcomes, the use of DAIR (debridement, antibiotics, and implant retention), 1-stage, 2-stage, and 1.5-stage procedures varies across regions and is often influenced by logistical constraints, resource availability, and clinical expertise. In parallel, discordant definitions of treatment success in the literature hinder comparative research and outcome benchmarking. A tiered framework-encompassing infection eradication, surgical burden, joint function, and patient-reported outcomes-offers a path toward standardized and clinically meaningful reporting.➢ Advances in immunogenetics, artificial intelligence-driven risk modeling, and precision medicine, alongside the emergence of research consortia and global collaborations, are opening new frontiers in treatment strategies and creating opportunities for innovative, individualized approaches to PJI management.
(五)全球范围内假体周围关节感染(PJI)发病率呈上升趋势,且存在较大的地区差异,PJI的5年死亡率为15% - 25%,超过早期乳腺癌和前列腺癌,与结直肠癌和血液系统恶性肿瘤的死亡率相当。(四)包括滑液分析、新型培养技术和分子技术在内的诊断标准的准确性有所提高。然而,由挑剔的、形成生物膜的微生物引起的感染继续在世界范围内构成主要的诊断挑战。虽然患者选择仍然是成功结果的关键,但DAIR(清创、抗生素和植入物保留)、1期、2期和1.5期手术的使用因地区而异,通常受到后勤限制、资源可用性和临床专业知识的影响。同时,文献中对治疗成功的不一致定义阻碍了比较研究和结果基准。分层框架——包括感染根除、手术负担、关节功能和患者报告的结果——为标准化和有临床意义的报告提供了途径。免疫遗传学、人工智能驱动的风险建模和精准医学的进步,以及研究联盟和全球合作的出现,正在开辟治疗策略的新领域,并为PJI管理的创新、个性化方法创造机会。
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引用次数: 0
Consensus Recommendations and Insights on Infection: Commentary on an article by the International Consensus Meeting Executive Committee: "International Consensus Meeting on Infection. Top 10 Evidence-Backed Recommendations and Insights". 关于感染的共识建议和见解:对国际共识会议执行委员会的一篇文章的评论:“国际感染共识会议”。十大循证建议和见解”。
Pub Date : 2025-11-19 DOI: 10.2106/jbjs.25.01070
Emil H Schemitsch
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引用次数: 0
Oral Corticosteroids Reduce Pain After Total Knee Arthroplasty: A Higher Dose of Dexamethasone Effectively Controlled Pain During Motion: A Dose-Response Randomized Placebo-Controlled Trial. 口服皮质类固醇减轻全膝关节置换术后疼痛:高剂量地塞米松有效控制运动疼痛:一项剂量-反应随机安慰剂对照试验。
Pub Date : 2025-11-18 DOI: 10.2106/jbjs.25.00642
Supakit Kanitnate,Yot Tanariyakul,Pattaranatcha Charnwichai,Pimjai Anthanont,Sudsayam Manuwong,Nattapol Tammachote
BACKGROUNDIntravenous corticosteroids have been used to manage pain following total knee arthroplasty (TKA). Oral dexamethasone has good bioavailability and is suitable for ambulatory TKA. This study investigated the efficacy and dose-response relationship of oral dexamethasone in pain control after TKA.METHODSIn this randomized controlled trial, 120 Thai patients (mean, 68 ± 8 years; 86% female) undergoing primary TKA were allocated to 1 of 3 groups: 16 mg of oral dexamethasone (DEX-16), 8 mg of oral dexamethasone (DEX-8), or placebo. Dexamethasone or placebo was administered once daily, in the morning before surgery and the morning of the first 4 postoperative days. The primary outcome was pain at rest and during motion, measured over time. Linear mixed-effects modeling was used to compare outcomes between groups.RESULTSBoth DEX-8 and DEX-16 significantly reduced pain at rest within 48 hours postoperatively compared with placebo (p < 0.05). However, only DEX-16 significantly reduced pain during motion (p < 0.05). At 48 hours postoperatively, the DEX-16 group showed approximately 50% reductions in pain at rest (p < 0.001) and during motion (p = 0.006) relative to placebo.CONCLUSIONSOral dexamethasone was effective in reducing pain after TKA, with a 16-mg dose providing superior pain relief during motion, compared with an 8-mg dose, within the first 48 hours. These findings support the use of oral dexamethasone as part of multimodal pain management, particularly in an ambulatory TKA setting.LEVEL OF EVIDENCETherapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
背景:静脉注射皮质类固醇已被用于控制全膝关节置换术(TKA)后的疼痛。口服地塞米松具有良好的生物利用度,适用于门诊TKA。本研究探讨口服地塞米松对TKA术后疼痛控制的疗效及量效关系。方法在这项随机对照试验中,120例泰国患者(平均68±8岁,86%为女性)接受原发性TKA,被分为3组:口服地塞米松(DEX-16) 16 mg、口服地塞米松(DEX-8) 8 mg或安慰剂组。地塞米松或安慰剂每日1次,分别在手术前和术后4天的早晨给予。主要结果是休息和运动时的疼痛,随时间测量。采用线性混合效应模型比较各组间的结果。结果与安慰剂相比,DEX-8和DEX-16在术后48小时内明显减轻了休息疼痛(p < 0.05)。然而,只有DEX-16能显著减轻运动时疼痛(p < 0.05)。术后48小时,与安慰剂相比,DEX-16组在休息时(p < 0.001)和运动时(p = 0.006)疼痛减轻了约50%。结论口服地塞米松可有效减轻TKA后疼痛,与8mg剂量相比,16mg剂量在前48小时内可更好地缓解运动过程中的疼痛。这些发现支持使用口服地塞米松作为多模式疼痛管理的一部分,特别是在动态TKA设置。证据级别:治疗性i级。参见《作者说明》获得证据级别的完整描述。
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引用次数: 0
Normalization of Subchondral Bone Density Patterns After Surgical Treatment for Capitellar Osteochondritis Dissecans: A Quantitative Analysis. 解剖性小头骨软骨炎手术治疗后软骨下骨密度模式的正常化:定量分析。
Pub Date : 2025-11-18 DOI: 10.2106/jbjs.25.00212
Satoshi Miyamura,Ko Temporin,Yuji Miyoshi,Ryoya Shiode,Toru Iwahashi,Seiji Okada,Kunihiro Oka,Hiroyuki Tanaka,Tsuyoshi Murase,Kozo Shimada
BACKGROUNDCapitellar osteochondritis dissecans (OCD) is common in adolescent throwing athletes. Surgical treatment yields favorable clinical outcomes. However, the relationship between bone density and clinical outcomes following OCD treatment is not well understood. We hypothesized that surgery normalizes subchondral bone density distribution and that clinical outcome improvements correlate with the bone density changes. This study quantitatively analyzed these changes and compared different surgical techniques.METHODSFifty-one male ethnic Japanese patients with capitellar OCD treated surgically (mean age at surgery: 14.0 ± 1.6 years) were enrolled, with a mean follow-up of 6.7 ± 3.1 years (mean age at final evaluation: 20.7 ± 3.5 years). Subchondral bone density was measured in Hounsfield units using computed tomography preoperatively and postoperatively, as well as in the contralateral elbow. Relative bone densities, expressed as proportions, in the distal humerus, radial head, and proximal ulna were compared among the preoperative, postoperative, and contralateral elbows within their respective anatomical subregions. Subgroups with reconstruction procedures and with preservation procedures were also analyzed separately. Functional outcome changes using Timmerman-Andrews scores were correlated with bone density changes.RESULTSIn the distal humerus, subchondral bone density at the OCD lesion was significantly lower preoperatively (0.99 ± 0.17) than postoperatively (1.19 ± 0.17, p < 0.001) and in the contralateral elbow (1.17 ± 0.13, p < 0.001), whereas the density of the surrounding sclerotic bone was higher preoperatively (1.24 ± 0.10) than postoperatively (1.14 ± 0.10, p < 0.001) and in the contralateral elbow (1.07 ± 0.08, p < 0.001). The regions within and outside the site of the OCD lesion exhibited similar density distribution patterns postoperatively and in the contralateral elbow. In the radial head, the highest density was in the radial-volar quadrant preoperatively (1.14 ± 0.14) but shifted to the ulnar-volar quadrant postoperatively (1.06 ± 0.12, p = 0.020) and matched the contralateral value (1.02 ± 0.10, p < 0.001). Patterns in subchondral bone density in the regions were comparable between the reconstruction and preservation groups across all conditions. Improvements in Timmerman-Andrews scores correlated moderately with bone density normalization at the lesion site (R = 0.49, p = 0.003) and surrounding sclerotic bone (R = 0.43, p = 0.010).CONCLUSIONSSurgical treatment of capitellar OCD effectively restored the subchondral bone density distribution to normal patterns, regardless of the surgical technique. These bone density changes moderately correlated with improvements in functional outcome, providing quantitative evidence supporting the efficacy of surgical intervention for advanced lesions.LEVEL OF EVIDENCETherapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
背景:小骨软骨炎(OCD)在青少年投掷运动员中很常见。手术治疗的临床效果良好。然而,骨密度与强迫症治疗后临床结果之间的关系尚不清楚。我们假设手术使软骨下骨密度分布正常化,并且临床结果的改善与骨密度的改变相关。本研究定量分析了这些变化,并比较了不同的手术技术。方法51例经手术治疗的日本男性小头强迫症患者(平均手术年龄:14.0±1.6岁),平均随访6.7±3.1年(最终评估时平均年龄:20.7±3.5岁)。术前、术后使用计算机断层扫描测量霍斯菲尔德单位的软骨下骨密度,以及对侧肘关节。比较术前、术后和对侧肘关节在各自解剖亚区中肱骨远端、桡骨头和尺骨近端相对骨密度(以比例表示)。重建组和保存组的亚组也分别进行分析。使用Timmerman-Andrews评分的功能结果变化与骨密度变化相关。结果肱骨远端OCD病变软骨下骨密度(0.99±0.17)明显低于术后(1.19±0.17,p < 0.001)和对侧肘关节软骨下骨密度(1.17±0.13,p < 0.001),而周围硬化骨密度(1.24±0.10)明显高于术后(1.14±0.10,p < 0.001)和对侧肘关节软骨下骨密度(1.07±0.08,p < 0.001)。OCD病变部位内外的密度分布模式与对侧肘关节相似。术前桡骨头桡掌象限密度最高(1.14±0.14),术后尺掌象限密度最高(1.06±0.12,p = 0.020),与对侧吻合(1.02±0.10,p < 0.001)。在所有条件下,重建组和保存组之间区域的软骨下骨密度模式具有可比性。Timmerman-Andrews评分的改善与病变部位骨密度正常化(R = 0.49, p = 0.003)和周围硬化骨(R = 0.43, p = 0.010)中度相关。结论手术治疗小头强迫症可使软骨下骨密度分布恢复正常,与手术技术无关。这些骨密度变化与功能结果的改善中度相关,为晚期病变手术干预的有效性提供了定量证据。证据水平:治疗性三级。有关证据水平的完整描述,请参见作者说明。
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引用次数: 0
Weight Loss After Joint Replacement: Fact or Fiction?: Commentary on an article by Daniel Karczewski, MD, et al.: "Mean Body Mass Index Does Not Increase or Decrease at 10 Years After Primary Total Hip or Knee Arthroplasty". 关节置换术后体重减轻:事实还是虚构?:对Daniel Karczewski, MD等人的文章的评论:“初次全髋关节或膝关节置换术后10年,平均体重指数不会增加或减少”。
Pub Date : 2025-11-05 DOI: 10.2106/jbjs.25.01006
Lisa C Howard
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引用次数: 0
Helical Blade Versus Lag Screw Fixation in the Cephalomedullary Nailing of Geriatric Hip Fractures. 螺旋刀片与拉力螺钉在老年髋部骨折头髓内钉中的应用。
Pub Date : 2025-11-03 DOI: 10.2106/jbjs.25.00294
Kanu Okike,Richard N Chang,Andrew S Fang,Cameron Sadeghi,Ronald A Navarro,Bobby Dezfuli,Kathryn E Royse,Brian H Fasig,Elizabeth W Paxton
BACKGROUNDWhile some prior research has shown helical blades to have higher risks of fixation failure and cut-out than lag screws in the cephalomedullary nailing of intertrochanteric femoral fractures, other studies have not demonstrated any such differences. The purpose of this study was to compare the performance of helical blade and lag screw fixation among older patients with a hip fracture treated with cephalomedullary nailing and to determine whether the relative performance of these 2 fixation methods varies on the basis of patient characteristics.METHODSThis retrospective cohort study utilized the hip fracture registry of an integrated health-care system to identify patients ≥60 years old who underwent cephalomedullary nailing with a helical blade or lag screw from 2009 to 2023. Propensity score-weighted Cox proportional hazards regression was used to evaluate the risk of aseptic revision (the primary outcome measure) and the risks of revision for specific reasons (the secondary outcome measures), with mortality considered as a competing risk.RESULTSThe study sample included 22,308 cases (11,877 with a helical blade and 10,431 with a lag screw; mean patient age, 81.7 years; 71.5% female; 73.3% White; 71.8% with an American Society of Anesthesiologists [ASA] classification of ≥3). The 10-year cumulative incidence of aseptic revision was 1.69% (n = 194) in the helical blade group and 1.88% (n = 182) in the lag screw group (adjusted hazard ratio [HR], 0.87; 95% confidence interval [CI], 0.69 to 1.11; p = 0.27). There was evidence of effect modification by ASA classification, with the helical blade outperforming the lag screw in patients with an ASA of 1 to 2 (aseptic revision incidence, 1.74% versus 2.56%; adjusted HR, 0.65; 95% CI, 0.43 to 0.98; p = 0.04) but not in those with an ASA of ≥3 (aseptic revision incidence, 1.72% versus 1.64%; adjusted HR, 1.03; 95% CI, 0.78 to 1.35; p = 0.85). There was no evidence of effect modification by age or sex.CONCLUSIONSIn this study of geriatric patients with a hip fracture treated with cephalomedullary nailing, helical blade and lag screw fixation performed similarly overall. Our finding that helical blade fixation may perform better in healthier (ASA 1 to 2) geriatric patients is interesting and deserves further investigation.LEVEL OF EVIDENCETherapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
虽然一些先前的研究表明,在股骨粗隆间骨折的头髓内钉治疗中,螺旋刀片比拉力螺钉有更高的固定失败和切断的风险,但其他研究并没有显示任何这样的差异。本研究的目的是比较采用头髓内钉治疗老年髋部骨折患者的螺旋刀片和拉力螺钉固定的效果,并确定这两种固定方法的相对效果是否会因患者的特点而有所不同。方法:本回顾性队列研究利用综合医疗保健系统的髋部骨折登记,识别2009年至2023年期间接受螺旋刀片或螺钉头髓内钉治疗的≥60岁患者。使用倾向评分加权Cox比例风险回归来评估无菌翻修的风险(主要结局指标)和特定原因翻修的风险(次要结局指标),死亡率被认为是一个竞争风险。结果共纳入22308例患者,其中螺旋刀11877例,螺钉10431例,平均年龄81.7岁,女性占71.5%,白人占73.3%,美国麻醉医师学会(ASA)分级≥3级者占71.8%。螺旋刀组10年累积无菌翻修发生率为1.69% (n = 194),螺钉组为1.88% (n = 182)(校正风险比[HR] 0.87; 95%可信区间[CI] 0.69 ~ 1.11; p = 0.27)。有证据表明,ASA分级对疗效有改善作用,在ASA为1 ~ 2的患者中,螺旋刀片优于螺钉(无菌改良发生率1.74%比2.56%;校正HR 0.65; 95% CI 0.43 ~ 0.98; p = 0.04),而在ASA≥3的患者中则没有效果(无菌改良发生率1.72%比1.64%;校正HR 1.03; 95% CI 0.78 ~ 1.35; p = 0.85)。没有证据表明年龄或性别对效果有影响。结论:在本研究中,采用头髓内钉治疗的老年髋部骨折患者,螺旋刀片和拉力螺钉固定的总体效果相似。我们发现螺旋刀片固定在健康(ASA 1 - 2)的老年患者中可能表现更好,这是有趣的,值得进一步研究。证据水平:治疗性三级。有关证据水平的完整描述,请参见作者说明。
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引用次数: 0
Appreciating the Role of Narrative Medicine in Orthopaedic Surgery. 论叙事医学在骨科手术中的作用。
Pub Date : 2025-11-03 DOI: 10.2106/jbjs.25.00486
Eve R Glenn,Brienna K Buchanan,Grace Q Chen,Ysa Le,Samalya Thenuwara,Dawn M LaPorte,Richard A Schaefer
{"title":"Appreciating the Role of Narrative Medicine in Orthopaedic Surgery.","authors":"Eve R Glenn,Brienna K Buchanan,Grace Q Chen,Ysa Le,Samalya Thenuwara,Dawn M LaPorte,Richard A Schaefer","doi":"10.2106/jbjs.25.00486","DOIUrl":"https://doi.org/10.2106/jbjs.25.00486","url":null,"abstract":"","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145433686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
The Journal of Bone & Joint Surgery
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