Pub Date : 2025-12-10DOI: 10.1016/s1474-4422(25)00356-4
Martina Glavan, Jia Liu, Gisele Sampaio Silva, Thanh N Nguyen, Jiangbing Zhou, Nenad Sestan, W Taylor Kimberly, Kevin N Sheth
{"title":"Endovascular thrombectomy for acute stroke: evolving eligibility criteria and adjunct therapies","authors":"Martina Glavan, Jia Liu, Gisele Sampaio Silva, Thanh N Nguyen, Jiangbing Zhou, Nenad Sestan, W Taylor Kimberly, Kevin N Sheth","doi":"10.1016/s1474-4422(25)00356-4","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00356-4","url":null,"abstract":"","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145730694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/s1474-4422(25)00448-x
Elena Moro
No Abstract
没有抽象的
{"title":"Movement disorders in 2025: advances in early diagnosis and personalised treatment","authors":"Elena Moro","doi":"10.1016/s1474-4422(25)00448-x","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00448-x","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"14 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/s1474-4422(25)00440-5
Emmanuel Drouin, Patrick Hautecoeur, Arnaud Kwiatkowski
No Abstract
没有抽象的
{"title":"Raoul-Michel May, a pioneer in nerve grafting","authors":"Emmanuel Drouin, Patrick Hautecoeur, Arnaud Kwiatkowski","doi":"10.1016/s1474-4422(25)00440-5","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00440-5","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/s1474-4422(25)00432-6
Lorraine V Kalia
{"title":"Exploring immunomodulation with azathioprine in Parkinson's disease","authors":"Lorraine V Kalia","doi":"10.1016/s1474-4422(25)00432-6","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00432-6","url":null,"abstract":"","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145730697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/s1474-4422(25)00382-5
Matheus de Castro Fonseca, Letizia Zanetti, Stavros Fanourakis, David L Sulzer, Sarkis K Mazmanian
Inflammation is a core feature of Parkinson's disease, extending beyond the CNS to include systemic immune activation. The gut microbiome is increasingly recognised as a key regulator of immune function in the gastrointestinal tract, peripheral circulation, and brain. In individuals with Parkinson's disease, gut microbial composition is altered, with reductions in anti-inflammatory taxa and increases in pro-inflammatory bacterial species. Preclinical studies have shown that microbiome alterations can promote α-synuclein aggregation and neuroinflammation, whereas human data suggest early involvement of the gut and immune system. Immune-mediated mechanisms in Parkinson's disease include activation of brain resident microglia and peripheral innate and adaptive immune cells. Emerging evidence suggests the gut microbiome modulates systemic immune activation, through autoreactive T cells that might drive neurodegeneration. An improved understanding of how the microbiome shapes inflammation and autoimmunity in Parkinson's disease could inform the development of therapies that target the immune system or the gut–brain axis.
{"title":"The gut microbiome, systemic inflammation, and autoimmunity in Parkinson's disease","authors":"Matheus de Castro Fonseca, Letizia Zanetti, Stavros Fanourakis, David L Sulzer, Sarkis K Mazmanian","doi":"10.1016/s1474-4422(25)00382-5","DOIUrl":"https://doi.org/10.1016/s1474-4422(25)00382-5","url":null,"abstract":"Inflammation is a core feature of Parkinson's disease, extending beyond the CNS to include systemic immune activation. The gut microbiome is increasingly recognised as a key regulator of immune function in the gastrointestinal tract, peripheral circulation, and brain. In individuals with Parkinson's disease, gut microbial composition is altered, with reductions in anti-inflammatory taxa and increases in pro-inflammatory bacterial species. Preclinical studies have shown that microbiome alterations can promote α-synuclein aggregation and neuroinflammation, whereas human data suggest early involvement of the gut and immune system. Immune-mediated mechanisms in Parkinson's disease include activation of brain resident microglia and peripheral innate and adaptive immune cells. Emerging evidence suggests the gut microbiome modulates systemic immune activation, through autoreactive T cells that might drive neurodegeneration. An improved understanding of how the microbiome shapes inflammation and autoimmunity in Parkinson's disease could inform the development of therapies that target the immune system or the gut–brain axis.","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145717567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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