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C-arm technique using distance driven method for nephrolithiasis and kidney stones detection c臂技术应用距离驱动法进行肾结石和肾结石的检测
Pub Date : 2016-04-04 DOI: 10.1117/12.2217213
Nuhad A. Malalla, Pengfei Sun, Ying Chen, M. Lipkin, G. Preminger, Jun Qin
Distance driven represents a state of art method that used for reconstruction for x-ray techniques. C-arm tomography is an x-ray imaging technique that provides three dimensional information of the object by moving the C-shaped gantry around the patient. With limited view angle, C-arm system was investigated to generate volumetric data of the object with low radiation dosage and examination time. This paper is a new simulation study with two reconstruction methods based on distance driven including: simultaneous algebraic reconstruction technique (SART) and Maximum Likelihood expectation maximization (MLEM). Distance driven is an efficient method that has low computation cost and free artifacts compared with other methods such as ray driven and pixel driven methods. Projection images of spherical objects were simulated with a virtual C-arm system with a total view angle of 40 degrees. Results show the ability of limited angle C-arm technique to generate three dimensional images with distance driven reconstruction.
距离驱动代表了用于x射线技术重建的最先进的方法。c臂断层扫描是一种x射线成像技术,通过在患者周围移动c形龙门来提供物体的三维信息。在视角有限的情况下,研究了c臂系统在低辐射剂量和检测时间下生成物体体积数据的方法。本文研究了基于距离驱动的两种重构方法:同步代数重构技术(SART)和最大似然期望最大化(MLEM)。与射线驱动、像素驱动等方法相比,距离驱动是一种计算成本低、无伪影的有效方法。利用虚拟c型臂系统模拟了球形物体的投影图像,总视角为40度。结果表明,有限角度c臂技术能够生成距离驱动重构的三维图像。
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引用次数: 0
Estimating breast thickness for dual-energy subtraction in contrast-enhanced digital mammography using calibration phantoms 使用校准幻象估计对比度增强数字乳房x线照相术中双能量减影的乳房厚度
Pub Date : 2016-04-04 DOI: 10.1117/12.2214748
K. Lau, Y. Kwon, M. Aziz, R. Acciavatti, Andrew D. A. Maidment
Dual-energy contrast-enhanced digital mammography (DE CE-DM) uses an iodinated contrast agent to image the perfusion and vasculature of the breast. DE images are obtained by a weighted logarithmic subtraction of the high-energy (HE) and low-energy (LE) image pairs. We hypothesized that the optimal DE subtraction weighting factor is thickness-dependent, and developed a method for determining breast tissue composition and thickness in DE CE-DM. Phantoms were constructed using uniform blocks of 100% glandular-equivalent and 100% adipose-equivalent material. The thickness of the phantoms ranged from 3 to 8 cm, in 1 cm increments. For a given thickness, the glandular-adipose composition of the phantom was varied using different combinations of blocks. The logarithmic LE and logarithmic HE signal intensities were measured; they decrease linearly with increasing glandularity for a given thickness. The signals decrease with increasing phantom thickness and the x-ray signal decreases linearly with thickness for a given glandularity. As the thickness increases, the attenuation difference per additional glandular block decreases, indicating beam hardening. From the calibration mapping, we have demonstrated that we can predict percent glandular tissue and thickness when given two distinct signal intensities. Our results facilitate the subtraction of tissue at the boundaries of the breast, and aid in discriminating between contrast agent uptake in glandular tissue and subtraction artifacts.
双能量增强数字乳房x线摄影(DE CE-DM)使用碘化造影剂对乳房的灌注和血管系统进行成像。DE图像由高能(HE)和低能(LE)图像对的加权对数相减得到。我们假设最佳DE减去权重因子与厚度相关,并开发了一种确定DE CE-DM乳腺组织组成和厚度的方法。使用100%腺体当量和100%脂肪当量材料的均匀块构建模型。幽灵的厚度从3到8厘米不等,每增加1厘米。对于给定的厚度,使用不同的块组合可以改变幻肢的腺体脂肪组成。测量对数LE和对数HE信号强度;对于给定的厚度,它们随腺体的增加而线性减少。信号随幻体厚度的增加而减小,x射线信号随给定腺体厚度的增加而线性减小。随着厚度的增加,每个附加腺块的衰减差减小,表明梁硬化。从校准映射,我们已经证明,我们可以预测百分比腺体组织和厚度,当给定两个不同的信号强度。我们的结果有助于乳腺边界组织的减影,并有助于区分腺体组织中的造影剂摄取和减影伪影。
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引用次数: 4
Design, optimization and evaluation of a “smart” pixel sensor array for low-dose digital radiography 用于低剂量数字放射照相的“智能”像素传感器阵列的设计、优化和评估
Pub Date : 2016-04-04 DOI: 10.1117/12.2216780
Kai Wang, Xinghui Liu, H. Ou, Jun Chen
Amorphous silicon (a-Si:H) thin-film transistors (TFTs) have been widely used to build flat-panel X-ray detectors for digital radiography (DR). As the demand for low-dose X-ray imaging grows, a detector with high signal-to-noise-ratio (SNR) pixel architecture emerges. “Smart” pixel is intended to use a dual-gate photosensitive TFT for sensing, storage, and switch. It differs from a conventional passive pixel sensor (PPS) and active pixel sensor (APS) in that all these three functions are combined into one device instead of three separate units in a pixel. Thus, it is expected to have high fill factor and high spatial resolution. In addition, it utilizes the amplification effect of the dual-gate photosensitive TFT to form a one-transistor APS that leads to a potentially high SNR. This paper addresses the design, optimization and evaluation of the smart pixel sensor and array for low-dose DR. We will design and optimize the smart pixel from the scintillator to TFT levels and validate it through optical and electrical simulation and experiments of a 4x4 sensor array.
非晶硅(a-Si:H)薄膜晶体管(TFTs)已被广泛用于制造用于数字射线照相(DR)的平板x射线探测器。随着低剂量x射线成像需求的增长,一种具有高信噪比(SNR)像素结构的探测器应运而生。“智能”像素旨在使用双栅极光敏TFT进行传感,存储和开关。它与传统的无源像素传感器(PPS)和有源像素传感器(APS)的不同之处在于,所有这三种功能都被组合到一个设备中,而不是在一个像素中三个独立的单元。因此,期望具有高填充系数和高空间分辨率。此外,它利用双栅光敏TFT的放大效应,形成一个单晶体管APS,导致潜在的高信噪比。本文研究了用于低剂量dr的智能像素传感器和阵列的设计、优化和评估。我们将设计和优化从闪烁体到TFT级的智能像素,并通过4x4传感器阵列的光学和电学仿真和实验进行验证。
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引用次数: 0
On the properties of artificial neural network filters for bone-suppressed digital radiography 骨抑制数字摄影中人工神经网络滤波器的特性研究
Pub Date : 2016-04-04 DOI: 10.1117/12.2216739
E. Park, Junbeom Park, Dae-Hong Kim, H. Youn, H. Jeon, Jin Sung Kim, D. Kang, Ho Kyung Kim
Dual-energy imaging can enhance lesion conspicuity. However, the conventional (fast kilovoltage switching) dual-shot dual-energy imaging is vulnerable to patient motion. The single-shot method requires a special design of detector system. Alternatively, single-shot bone-suppressed imaging is possible using post-image processing combined with a filter obtained from training an artificial neural network. In this study, the authors investigate the general properties of artificial neural network filters for bone-suppressed digital radiography. The filter properties are characterized in terms of various parameters such as the size of input vector, the number of hidden units, the learning rate, and so on. The preliminary result shows that the bone-suppressed image obtained from the filter, which is designed with 5,000 teaching images from a single radiograph, results in about 95% similarity with a commercial bone-enhanced image.
双能成像可增强病变的显著性。然而,传统的(快速千伏开关)双镜头双能成像容易受到患者运动的影响。单发法需要特殊的探测器系统设计。或者,单镜头骨抑制成像是可能的,使用图像后处理与训练人工神经网络获得的滤波器相结合。在这项研究中,作者研究了骨抑制数字x线摄影的人工神经网络滤波器的一般性质。滤波器的特性是根据各种参数来描述的,比如输入向量的大小、隐藏单元的数量、学习率等等。初步结果表明,该滤波器使用来自单张x光片的5000张教学图像设计得到的骨抑制图像与商业骨增强图像的相似性约为95%。
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引用次数: 1
Low-dose performance of a whole-body research photon-counting CT scanner 全身光子计数CT扫描仪的低剂量性能研究
Pub Date : 2016-04-04 DOI: 10.1117/12.2217240
Z. Yu, S. Leng, S. Kappler, K. Hahn, Zhoubo Li, A. Halaweish, A. Henning, E. Ritman, C. McCollough
Photon-counting CT (PCCT) is an emerging technique that may bring new possibilities to clinical practice. Compared to conventional CT, PCCT is able to exclude electronic noise that may severely impair image quality at low photon counts. This work focused on assessing the low-dose performance of a whole-body research PCCT scanner consisting of two subsystems, one equipped with an energy-integrating detector, and the other with a photon-counting detector. Evaluation of the low-dose performance of the research PCCT scanner was achieved by comparing the noise performance of the two subsystems, with an emphasis on examining the impact of electronic noise on image quality in low-dose situations.
光子计数CT (PCCT)是一项新兴技术,可能为临床实践带来新的可能性。与传统CT相比,PCCT能够排除在低光子计数时可能严重损害图像质量的电子噪声。这项工作的重点是评估由两个子系统组成的全身研究PCCT扫描仪的低剂量性能,其中一个子系统配备了能量积分探测器,另一个子系统配备了光子计数探测器。通过比较两个子系统的噪声性能,对研究PCCT扫描仪的低剂量性能进行了评估,重点研究了低剂量情况下电子噪声对图像质量的影响。
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引用次数: 9
Ray tracing reconstruction investigation for C-arm tomosynthesis c臂断层合成的射线追踪重建研究
Pub Date : 2016-04-04 DOI: 10.1117/12.2217199
Nuhad A. Malalla, Ying Chen
C-arm tomosynthesis is a three dimensional imaging technique. Both x-ray source and the detector are mounted on a C-arm wheeled structure to provide wide variety of movement around the object. In this paper, C-arm tomosynthesis was introduced to provide three dimensional information over a limited view angle (less than 180o) to reduce radiation exposure and examination time. Reconstruction algorithms based on ray tracing method such as ray tracing back projection (BP), simultaneous algebraic reconstruction technique (SART) and maximum likelihood expectation maximization (MLEM) were developed for C-arm tomosynthesis. C-arm tomosynthesis projection images of simulated spherical object were simulated with a virtual geometric configuration with a total view angle of 40 degrees. This study demonstrated the sharpness of in-plane reconstructed structure and effectiveness of removing out-of-plane blur for each reconstruction algorithms. Results showed the ability of ray tracing based reconstruction algorithms to provide three dimensional information with limited angle C-arm tomosynthesis.
c臂断层合成是一种三维成像技术。x射线源和探测器都安装在c臂轮式结构上,以提供物体周围各种各样的运动。本文引入了c臂断层合成技术,在有限的视角(小于180度)内提供三维信息,以减少辐射暴露和检查时间。提出了基于射线追踪法的c臂断层合成重建算法,如射线追踪回投影(BP)、同步代数重建技术(SART)和最大似然期望最大化(MLEM)。以总视角为40度的虚拟几何构型模拟模拟球形物体的c臂断层合成投影图像。本研究证明了各重建算法在面内重构结构的清晰度和去除面外模糊的有效性。结果表明,基于光线追踪的重建算法能够提供有限角度c臂断层合成的三维信息。
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引用次数: 0
Evaluation of a projection-domain lung nodule insertion technique in thoracic CT 胸部CT投影域肺结节插入技术的评价
Pub Date : 2016-04-04 DOI: 10.1117/12.2217009
Chi Ma, Baiyu Chen, C. W. Koo, E. Takahashi, J. Fletcher, C. McCollough, D. Levin, R. Kuzo, Lyndsay D. Viers, Stephanie A. Vincent Sheldon, S. Leng, Lifeng Yu
Task-based assessment of computed tomography (CT) image quality requires a large number of cases with ground truth. Inserting lesions into existing cases to simulate positive cases is a promising alternative approach. The aim of this study was to evaluate a recently-developed raw-data based lesion insertion technique in thoracic CT. Lung lesions were segmented from patient CT images, forward projected, and reinserted into the same patient CT projection data. In total, 32 nodules of various attenuations were segmented from 21 CT cases. Two experienced radiologists and 2 residents blinded to the process independently evaluated these inserted nodules in two sub-studies. First, the 32 inserted and the 32 original nodules were presented in a randomized order and each received a rating score from 1 to 10 (1=absolutely artificial to 10=absolutely realistic). Second, the inserted and the corresponding original lesions were presented side-by-side to each reader, who identified the inserted lesion and provided a confidence score (1=no confidence to 5=completely certain). For the randomized evaluation, discrimination of real versus artificial nodules was poor with areas under the receiver operative characteristic curves being 0.69 (95% CI: 0.58-0.78), 0.57 (95% CI: 0.46-0.68), and 0.62 (95% CI: 0.54-0.69) for the 2 radiologists, 2 residents, and all 4 readers, respectively. For the side-by-side evaluation, although all 4 readers correctly identified inserted lesions in 103/128 pairs, the confidence score was moderate (2.6). Our projection-domain based lung nodule insertion technique provides a robust method to artificially generate clinical cases that prove to be difficult to differentiate from real cases.
基于任务的计算机断层扫描(CT)图像质量评估需要大量的真实案例。在现有病例中插入病变以模拟阳性病例是一种很有前途的替代方法。本研究的目的是评估最近发展的基于原始数据的胸部CT病变插入技术。从患者CT图像中分割肺部病变,向前投影,并重新插入到相同的患者CT投影数据中。共从21例CT上分割出32个不同程度衰减的结节。两名经验丰富的放射科医生和两名不知情的住院医生在两个亚研究中独立评估了这些插入结节。首先,32个插入的结节和32个原始结节按随机顺序呈现,每个结节获得1到10的评分(1=绝对人工到10=绝对真实)。其次,将插入的病变和相应的原始病变并排呈现给每位读者,由读者识别插入的病变并给出置信度评分(1=无置信度至5=完全确定)。在随机评价中,2名放射科医生、2名住院医生和所有4名读者对真实结节和人工结节的辨别能力较差,分别为0.69 (95% CI: 0.58-0.78)、0.57 (95% CI: 0.46-0.68)和0.62 (95% CI: 0.54-0.69)。对于并排评估,虽然所有4位读者在103/128对中正确识别插入病变,但置信度评分为中等(2.6)。我们基于投影域的肺结节插入技术提供了一种强大的方法来人工生成临床病例,这些病例被证明很难与真实病例区分开来。
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引用次数: 6
Synthesized interstitial lung texture for use in anthropomorphic computational phantoms 合成肺间质纹理,用于拟人化计算模型
Pub Date : 2016-04-04 DOI: 10.1117/12.2217135
M. Becchetti, J. Solomon, W. Segars, E. Samei
A realistic model of the anatomical texture from the pulmonary interstitium was developed with the goal of extending the capability of anthropomorphic computational phantoms (e.g., XCAT, Duke University), allowing for more accurate image quality assessment. Contrast-enhanced, high dose, thorax images for a healthy patient from a clinical CT system (Discovery CT750HD, GE healthcare) with thin (0.625 mm) slices and filtered back- projection (FBP) were used to inform the model. The interstitium which gives rise to the texture was defined using 24 volumes of interest (VOIs). These VOIs were selected manually to avoid vasculature, bronchi, and bronchioles. A small scale Hessian-based line filter was applied to minimize the amount of partial-volumed supernumerary vessels and bronchioles within the VOIs. The texture in the VOIs was characterized using 8 Haralick and 13 gray-level run length features. A clustered lumpy background (CLB) model with added noise and blurring to match CT system was optimized to resemble the texture in the VOIs using a genetic algorithm with the Mahalanobis distance as a similarity metric between the texture features. The most similar CLB model was then used to generate the interstitial texture to fill the lung. The optimization improved the similarity by 45%. This will substantially enhance the capabilities of anthropomorphic computational phantoms, allowing for more realistic CT simulations.
开发了肺间质解剖纹理的逼真模型,目的是扩展仿人计算模型的能力(例如,XCAT,杜克大学),允许更准确的图像质量评估。使用临床CT系统(Discovery CT750HD, GE healthcare)的健康患者的对比度增强,高剂量的胸部图像,薄(0.625 mm)切片和过滤后投影(FBP)来告知模型。产生纹理的间质使用24个感兴趣体积(voi)来定义。这些voi是手工选择的,以避免血管、支气管和细支气管。应用小规模的hessian线滤波器来最小化voi内部分体积的多余血管和细支气管的数量。使用8个Haralick特征和13个灰度运行长度特征来表征voi中的纹理。采用Mahalanobis距离作为纹理特征之间的相似度度量,利用遗传算法对加入噪声和模糊的聚类块背景(CLB)模型进行优化,使其与CT系统中的纹理相似。然后使用最相似的CLB模型生成间质纹理以填充肺。优化后的相似性提高了45%。这将大大提高拟人化计算幻影的能力,允许更真实的CT模拟。
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引用次数: 2
Large-pitch steerable synthetic transmit aperture imaging (LPSSTA) 大螺距可操纵合成透射孔径成像
Pub Date : 2016-04-01 DOI: 10.1117/12.2216908
Y. Li, Michael C. Kolios, Yuan Xu
A linear ultrasound array system usually has a larger pitch and is less costly than a phased array system, but loses the ability to fully steer the ultrasound beam. In this paper, we propose a system whose hardware is similar to a large-pitch linear array system, but whose ability to steer the beam is similar to a phased array system. The motivation is to reduce the total number of measurement channels M (the product of the number of transmissions, nT, and the number of the receive channels in each transmission, nR), while maintaining reasonable image quality. We combined adjacent elements (with proper delays introduced) into groups that would be used in both the transmit and receive processes of synthetic transmit aperture imaging. After the M channels of RF data were acquired, a pseudo-inversion was applied to estimate the equivalent signal in traditional STA to reconstruct a STA image. Even with the similar M, different choices of nT and nR will produce different image quality. The images produced with M=N2/15 in the selected regions of interest (ROI) were demonstrated to be comparable with a full phased array, where N is the number of the array elements. The disadvantage of the proposed system is that its field of view in one delay-configuration is smaller than a standard full phased array. However, by adjusting the delay for each element within each group, the beam can be steered to cover the same field of view as the standard fully-filled phased array. The LPSSTA system might be useful for 3D ultrasound imaging.
线性超声阵列系统通常比相控阵系统具有更大的间距和更低的成本,但失去了完全控制超声波束的能力。在本文中,我们提出了一个系统,它的硬件类似于一个大间距线性阵列系统,但其控制光束的能力类似于相控阵系统。其动机是在保持合理图像质量的同时,减少测量通道总数M(每次传输的传输通道数nT与每次传输的接收通道数nR的乘积)。我们将相邻的元素(引入适当的延迟)组合成一组,用于合成发射孔径成像的发射和接收过程。在采集到M个信道的射频数据后,利用伪反演方法估计传统STA中的等效信号,重建STA图像。即使M相似,选择不同的nT和nR也会产生不同的图像质量。在选定的感兴趣区域(ROI)中,用M=N2/15产生的图像被证明与全相控阵相当,其中N是阵列元素的数量。该系统的缺点是其在一个延迟配置下的视场小于标准的全相控阵。然而,通过调整每组中每个元件的延迟,可以引导波束覆盖与标准全填充相控阵相同的视场。LPSSTA系统可用于三维超声成像。
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引用次数: 1
A beamforming method for plane wave Doppler imaging of high flow velocities 高流速平面波多普勒成像的波束形成方法
Pub Date : 2016-04-01 DOI: 10.1117/12.2217226
O. Mansour, T. Poepping, J. Lacefield
Plane wave imaging is desirable for its ability to achieve high frame rates, allowing the capture of fast dynamic events, and continuous Doppler data. In most implementations of plane-wave imaging, multiple low resolution image (LRI) frames from different plane wave tilt angles are compounded to form a single high resolution image (HRI) frame, thereby reducing the frame rate. Compounding is a low-pass mean filter that causes attenuation and aliasing to signals with high Doppler shifts. On the other hand, the lateral beam profile and hence the quality of the HRI frames is improved by increasing the number of compounded frames. Therefore, a tradeoff exists between the Doppler limits and beam profile. In this paper, we present a method that eliminates this tradeoff and produces high resolution images without the use of compounding. The method suppresses the off-focus (clutter) signal by spreading its spectrum, while keeping the spectrum of the in-focus signal intact. The spreading is achieved by using a random sequence of tilt angles, as opposed to a linear sweep. Experiments performed using a carotid vessel phantom with constant flow demonstrate that the spread-spectrum method more accurately measures the parabolic flow profile of the vessel and in particular outperforms conventional plane-wave Doppler at higher flow velocities. The spread-spectrum method is expected to be valuable for Doppler applications that require measurement of high velocities at high frame rates.
平面波成像是理想的,因为它能够实现高帧率,允许捕获快速动态事件和连续的多普勒数据。在大多数平面波成像实现中,不同平面波倾斜角度的多个低分辨率图像(LRI)帧被复合成单个高分辨率图像(HRI)帧,从而降低了帧率。复合是一种低通平均滤波器,它对具有高多普勒频移的信号产生衰减和混叠。另一方面,通过增加复合框架的数量,可以改善侧梁轮廓,从而改善HRI框架的质量。因此,在多普勒限制和波束剖面之间存在权衡。在本文中,我们提出了一种方法,消除了这种权衡,并产生高分辨率的图像,而不使用复合。该方法通过扩展杂波信号的频谱来抑制离焦(杂波)信号,同时保持对焦信号的频谱不变。扩散是通过使用一个随机的倾斜角度序列来实现的,而不是线性扫描。使用恒定流量的颈动脉血管模型进行的实验表明,扩频方法更准确地测量血管的抛物流剖面,特别是在高流速下优于传统的平面波多普勒。扩频方法对于需要在高帧率下测量高速的多普勒应用是有价值的。
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引用次数: 1
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SPIE Medical Imaging
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