Pub Date : 2026-02-02DOI: 10.1016/s1470-2045(25)00661-8
H Lalchungnunga, Christopher H Dampier, Omkar Singh, Danh-Tai Hoang, Eldad D Shulman, Zied Abdullaev, Bochong Li, Zhirui Luo, Zhichao Wu, Thomas M Pearce, Daniel F Marker, Kathleen McCortney, Craig Horbinski, Calixto-Hope G Lucas, Patrick J Cimino, MacLean P Nasrallah, Martha Quezado, Hye-Jung Chung, Leeor Yefet, Gelareh Zadeh, Sebastian Brandner, Eytan Ruppin, Kenneth Aldape
{"title":"Classification accuracy of a hierarchical molecular inference-based deep-learning system for CNS tumour diagnosis: a multi-institutional, retrospective study","authors":"H Lalchungnunga, Christopher H Dampier, Omkar Singh, Danh-Tai Hoang, Eldad D Shulman, Zied Abdullaev, Bochong Li, Zhirui Luo, Zhichao Wu, Thomas M Pearce, Daniel F Marker, Kathleen McCortney, Craig Horbinski, Calixto-Hope G Lucas, Patrick J Cimino, MacLean P Nasrallah, Martha Quezado, Hye-Jung Chung, Leeor Yefet, Gelareh Zadeh, Sebastian Brandner, Eytan Ruppin, Kenneth Aldape","doi":"10.1016/s1470-2045(25)00661-8","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00661-8","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1016/s1470-2045(25)00670-9
Erica C Kaye, Jori Bogetz, Krysta S Barton, Cynthia J Bell, Emily E Johnston, Rachel A Pozzar, Alexandra Superdock, Sally Thorne, Meaghann S Weaver, Lori Wiener, Dylan E Graetz, Asya Agulnik, Prasanna Ananth, Krysta Barton, Cynthia Bell, Tharwa Bilbeisi, Myra Bluebond-Langner, Jori Bogetz, Gemma Bryan, Ana Cáceres, Erica Carlisle, Lara Counts, Gia Ferrara, Lucia Fuentes, Dylan Graetz, Julia Hanebrink, Anthony Herbert, Pamela Hinds, Jason Hodges, Liza Johnson, Emily Johnston, Erica Kaye, Jennifer W. Mack, Sara Malone, Kimberly Montez, Heather Schacht Reisinger, Rawad Rihani, Marta Salek, Bryan A. Sisk, Alexandra Superdock, Sally Thorne, Claire Wakefield, Lori Wiener, Anneliese Williams, Francesca Williamson, Kayla Wynja, Camilla Zimmermann, Meaghann Weaver, Rachel Pozzar
{"title":"Expert recommendations for the conduct and appraisal of qualitative research in oncology","authors":"Erica C Kaye, Jori Bogetz, Krysta S Barton, Cynthia J Bell, Emily E Johnston, Rachel A Pozzar, Alexandra Superdock, Sally Thorne, Meaghann S Weaver, Lori Wiener, Dylan E Graetz, Asya Agulnik, Prasanna Ananth, Krysta Barton, Cynthia Bell, Tharwa Bilbeisi, Myra Bluebond-Langner, Jori Bogetz, Gemma Bryan, Ana Cáceres, Erica Carlisle, Lara Counts, Gia Ferrara, Lucia Fuentes, Dylan Graetz, Julia Hanebrink, Anthony Herbert, Pamela Hinds, Jason Hodges, Liza Johnson, Emily Johnston, Erica Kaye, Jennifer W. Mack, Sara Malone, Kimberly Montez, Heather Schacht Reisinger, Rawad Rihani, Marta Salek, Bryan A. Sisk, Alexandra Superdock, Sally Thorne, Claire Wakefield, Lori Wiener, Anneliese Williams, Francesca Williamson, Kayla Wynja, Camilla Zimmermann, Meaghann Weaver, Rachel Pozzar","doi":"10.1016/s1470-2045(25)00670-9","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00670-9","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1016/s1470-2045(25)00658-8
Chad Tang, Alex D Sherry, Hyunsoo Hwang, David P Farris, Giulio Francolini, Vanessa Di Cataldo, Lorenzo Livi, Phuoc Tran, Paul G Corn, Ana Aparicio, Gabriele Simontacchi, Ana P Kiess, Jarey H Wang, Valerie Fonteyne, Renee Bultijnck, Ryan Phillips, Matthew P Deek, Robert Olson, Stephen Harrow, Giulia Marvaso, Chiara Lorubbio, Barbara A Jereczek-Fossa, Ethan B Ludmir, Pierre Blanchard, Andrew Warner, Ryan Sun, David A Palma, Piet Ost
{"title":"Metastasis-directed therapy and standard of care versus standard of care for oligometastatic prostate cancer (WOLVERINE): a systematic review and individual patient data meta-analysis from the X-MET collaboration","authors":"Chad Tang, Alex D Sherry, Hyunsoo Hwang, David P Farris, Giulio Francolini, Vanessa Di Cataldo, Lorenzo Livi, Phuoc Tran, Paul G Corn, Ana Aparicio, Gabriele Simontacchi, Ana P Kiess, Jarey H Wang, Valerie Fonteyne, Renee Bultijnck, Ryan Phillips, Matthew P Deek, Robert Olson, Stephen Harrow, Giulia Marvaso, Chiara Lorubbio, Barbara A Jereczek-Fossa, Ethan B Ludmir, Pierre Blanchard, Andrew Warner, Ryan Sun, David A Palma, Piet Ost","doi":"10.1016/s1470-2045(25)00658-8","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00658-8","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1016/s1470-2045(26)00013-6
Bishal Gyawali, Samuel X Stevens, Laure-Anne Teuwen
{"title":"Factors that can make overall survival unreliable as a clinical trial outcome – Authors' reply","authors":"Bishal Gyawali, Samuel X Stevens, Laure-Anne Teuwen","doi":"10.1016/s1470-2045(26)00013-6","DOIUrl":"https://doi.org/10.1016/s1470-2045(26)00013-6","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1016/s1470-2045(25)00706-5
David J Stewart, Vivek Subbiah, Mathew Vogel, Tim Ramsay, Razelle Kurzrock
{"title":"Factors that can make overall survival unreliable as a clinical trial outcome","authors":"David J Stewart, Vivek Subbiah, Mathew Vogel, Tim Ramsay, Razelle Kurzrock","doi":"10.1016/s1470-2045(25)00706-5","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00706-5","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1016/s1470-2045(25)00669-2
Dylan E Graetz, Bryan A Sisk, Marta Salek, Lindsay J Blazin, Claire E Wakefield, Elise C Tarbi, Sally Thorne, Thomas W LeBlanc, Pamela S Hinds, Lara Traeger, Erica C Kaye
This Review underscores qualitative research as an indispensable facet of scientific inquiry to improve provision of safe, effective, and affordable care for patients with cancer worldwide. Representing a global working group of applied qualitative researchers, our multidisciplinary authorship team defines qualitative research, characterises its purpose and value, and describes specific ways in which qualitative inquiry is central to advancing cures, treatment, and quality of life in oncology. In this Review, we put forward an imperative for the use of qualitative methods to assess context, understand population needs, design interventions, optimise implementation, and investigate mechanisms of action underpinning changes in health outcomes. We highlight the ways in which qualitative methods capture cultural context, making them crucial for scientific inquiry, and discuss the importance of using qualitative research to define research priorities, uncover and address understudied topics, and elevate marginalised voices globally. Ultimately, this Review serves as a call to action for improved integration of qualitative scholarship across each stage of cancer research and establishes a roadmap for collaboration among clinicians, scientists, publishers, and funders to recognise qualitative research as essential for scientific advancement in the field of oncology.
{"title":"The power of words: evaluating the role of qualitative methods in cancer research","authors":"Dylan E Graetz, Bryan A Sisk, Marta Salek, Lindsay J Blazin, Claire E Wakefield, Elise C Tarbi, Sally Thorne, Thomas W LeBlanc, Pamela S Hinds, Lara Traeger, Erica C Kaye","doi":"10.1016/s1470-2045(25)00669-2","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00669-2","url":null,"abstract":"This Review underscores qualitative research as an indispensable facet of scientific inquiry to improve provision of safe, effective, and affordable care for patients with cancer worldwide. Representing a global working group of applied qualitative researchers, our multidisciplinary authorship team defines qualitative research, characterises its purpose and value, and describes specific ways in which qualitative inquiry is central to advancing cures, treatment, and quality of life in oncology. In this Review, we put forward an imperative for the use of qualitative methods to assess context, understand population needs, design interventions, optimise implementation, and investigate mechanisms of action underpinning changes in health outcomes. We highlight the ways in which qualitative methods capture cultural context, making them crucial for scientific inquiry, and discuss the importance of using qualitative research to define research priorities, uncover and address understudied topics, and elevate marginalised voices globally. Ultimately, this Review serves as a call to action for improved integration of qualitative scholarship across each stage of cancer research and establishes a roadmap for collaboration among clinicians, scientists, publishers, and funders to recognise qualitative research as essential for scientific advancement in the field of oncology.","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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