Pub Date : 2025-12-22DOI: 10.1016/s1470-2045(25)00680-1
Ilaria Betella, Lucia Ribero
{"title":"Is PORTEC-4a the tipping point in endometrial cancer management?","authors":"Ilaria Betella, Lucia Ribero","doi":"10.1016/s1470-2045(25)00680-1","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00680-1","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145814001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-22DOI: 10.1016/s1470-2045(25)00532-7
Jasper K W Gerritsen MD PhD, Philipp Karschnia MD MSc, Prof Lorenzo Bello MD PhD, Prof Shawn Hervey-Jumper MD, Jacob S Young MD, Prof Kathleen Seidel MD, Djaina D Satoer PhD, Prof Oliver Schnell MD MHBA, Michael Parsons PhD, Brian V Nahed MD, Grazia Menna MD, Nico Teske MD MSc, External Rater Panel, Keyoumars Ashkan, Marion Barberis, Chetan Bettegowda, Florien Boele, Richard W. Byrne, Daniel P. Cahill, Daniel Delev, Elke De Witte, Katharine Drummond, Johnny Duerinck, Gavin Dunn, Samuel Emerson, Yoshua Esquenazi, Christian F. Freyschlag, Marjolein Geurts, Rachel Grossman, Constantinos G. Hadjipanayis, Margret Jensdottir, Markus Klimek, Chanhung Lee, Amy Maguire, Alireza Mansouri, James M. Markert, Yoshitaka Narita, Alessandro Olivi, Johan Pallud, Karin Piil, Matthias Preusser, Alfredo Quinones-Hinojosa, Jane Skjøth-Rasmussen, Michael Sabel, Christian Senft, Susan Short, Ole S. Solheim, Walter Stummer, Andrea Szelényi, Einar O. Vik-Mo, Colin Watts, Michael Weller, Patrick Wen, Timothy R Smith MD PhD, Nader Sanai MD, Prof Sandro M Krieg MD MBA, Prof Philippe Schucht MD, Prof Marike L D Broekman MD PhD, Prof Steven De Vleeschouwer MD PhD, Prof Asgeir S Jakola MD PhD, Prof Martin J van den Bent MD PhD, Prof Susan M Chang MD, Michael A Vogelbaum MD PhD, Prof Arnaud J P E Vincent MD PhD, Prof Joerg-Christian Tonn MD, Prof Mitchel S Berger MD
Historically, the assessment of surgical outcomes in patients with glioma has been focused on technical outcomes, such as volumetric analysis of the residual tumour, progression-free survival, and overall survival. Other outcomes, such as neurological deficits, can be challenging to assess in an objective, quantifiable, and comprehensive manner. As a result, no consensus is available on methods to systematically evaluate perioperative neurological, language, cognitive, and functional outcomes in patients with glioma. This variability contributes to suboptimal outcomes, hinders uniformity across multicentre studies, and limits comparability of reported results. Therefore, standardising key aspects of perioperative outcome assessment is crucial for these patients. The Personalized Interventions and Outcomes in Neurosurgical Oncology Research (PIONEER) Consortium and the Response Assessment in Neuro-Oncology (RANO) resect group are collaborative, multidisciplinary efforts that aim to standardise and enhance research and clinical practices in surgical neuro-oncology. In this Policy Review, both working groups review the evidence and provide recommendations for the standardisation of perioperative assessment of neurological morbidity, language function, overall function, and quality of life in adult patients with glioma. The Policy Review offers, for the first time, a structured framework for perioperative outcome assessment in glioma surgery. It aims to reduce heterogeneity in practice, facilitate multicentre studies, and enhance the methodological quality of these studies through more consistent and reproducible methods. Furthermore, homogeneous data will facilitate advances in personalised surgical care by enabling advanced computational modelling techniques.
{"title":"A comprehensive framework for glioma surgery by the PIONEER Consortium and RANO resect group, part 2: perioperative recommendations for neurological, language, functional, and quality-of-life assessment","authors":"Jasper K W Gerritsen MD PhD, Philipp Karschnia MD MSc, Prof Lorenzo Bello MD PhD, Prof Shawn Hervey-Jumper MD, Jacob S Young MD, Prof Kathleen Seidel MD, Djaina D Satoer PhD, Prof Oliver Schnell MD MHBA, Michael Parsons PhD, Brian V Nahed MD, Grazia Menna MD, Nico Teske MD MSc, External Rater Panel, Keyoumars Ashkan, Marion Barberis, Chetan Bettegowda, Florien Boele, Richard W. Byrne, Daniel P. Cahill, Daniel Delev, Elke De Witte, Katharine Drummond, Johnny Duerinck, Gavin Dunn, Samuel Emerson, Yoshua Esquenazi, Christian F. Freyschlag, Marjolein Geurts, Rachel Grossman, Constantinos G. Hadjipanayis, Margret Jensdottir, Markus Klimek, Chanhung Lee, Amy Maguire, Alireza Mansouri, James M. Markert, Yoshitaka Narita, Alessandro Olivi, Johan Pallud, Karin Piil, Matthias Preusser, Alfredo Quinones-Hinojosa, Jane Skjøth-Rasmussen, Michael Sabel, Christian Senft, Susan Short, Ole S. Solheim, Walter Stummer, Andrea Szelényi, Einar O. Vik-Mo, Colin Watts, Michael Weller, Patrick Wen, Timothy R Smith MD PhD, Nader Sanai MD, Prof Sandro M Krieg MD MBA, Prof Philippe Schucht MD, Prof Marike L D Broekman MD PhD, Prof Steven De Vleeschouwer MD PhD, Prof Asgeir S Jakola MD PhD, Prof Martin J van den Bent MD PhD, Prof Susan M Chang MD, Michael A Vogelbaum MD PhD, Prof Arnaud J P E Vincent MD PhD, Prof Joerg-Christian Tonn MD, Prof Mitchel S Berger MD","doi":"10.1016/s1470-2045(25)00532-7","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00532-7","url":null,"abstract":"Historically, the assessment of surgical outcomes in patients with glioma has been focused on technical outcomes, such as volumetric analysis of the residual tumour, progression-free survival, and overall survival. Other outcomes, such as neurological deficits, can be challenging to assess in an objective, quantifiable, and comprehensive manner. As a result, no consensus is available on methods to systematically evaluate perioperative neurological, language, cognitive, and functional outcomes in patients with glioma. This variability contributes to suboptimal outcomes, hinders uniformity across multicentre studies, and limits comparability of reported results. Therefore, standardising key aspects of perioperative outcome assessment is crucial for these patients. The Personalized Interventions and Outcomes in Neurosurgical Oncology Research (PIONEER) Consortium and the Response Assessment in Neuro-Oncology (RANO) resect group are collaborative, multidisciplinary efforts that aim to standardise and enhance research and clinical practices in surgical neuro-oncology. In this Policy Review, both working groups review the evidence and provide recommendations for the standardisation of perioperative assessment of neurological morbidity, language function, overall function, and quality of life in adult patients with glioma. The Policy Review offers, for the first time, a structured framework for perioperative outcome assessment in glioma surgery. It aims to reduce heterogeneity in practice, facilitate multicentre studies, and enhance the methodological quality of these studies through more consistent and reproducible methods. Furthermore, homogeneous data will facilitate advances in personalised surgical care by enabling advanced computational modelling techniques.","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145814012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-22DOI: 10.1016/s1470-2045(25)00401-2
Chih-Hung Hsu MD, Zhihao Lu MD, Shegan Gao MD, Junye Wang MD, Jong-Mu Sun MD, Tianshu Liu MD, Qingxia Fan MD, Jun Cai BSc, Feijiao Ge MD, Sijing Li PhD, Li Zhang PhD, Edward Cha MD, Simon Allen PhD, Lin Shen MD
There is an unmet need for additional and more efficacious therapies for patients with unresectable metastatic oesophageal cancer. We aimed to evaluate the efficacy and safety of adding tiragolumab and atezolizumab to chemotherapy as first-line treatment for unresectable or metastatic oesophageal squamous cell carcinoma.
{"title":"Tiragolumab plus atezolizumab and chemotherapy as first-line treatment for patients with unresectable oesophageal squamous cell carcinoma (SKYSCRAPER-08): a randomised, double-blind, placebo-controlled, phase 3 trial","authors":"Chih-Hung Hsu MD, Zhihao Lu MD, Shegan Gao MD, Junye Wang MD, Jong-Mu Sun MD, Tianshu Liu MD, Qingxia Fan MD, Jun Cai BSc, Feijiao Ge MD, Sijing Li PhD, Li Zhang PhD, Edward Cha MD, Simon Allen PhD, Lin Shen MD","doi":"10.1016/s1470-2045(25)00401-2","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00401-2","url":null,"abstract":"There is an unmet need for additional and more efficacious therapies for patients with unresectable metastatic oesophageal cancer. We aimed to evaluate the efficacy and safety of adding tiragolumab and atezolizumab to chemotherapy as first-line treatment for unresectable or metastatic oesophageal squamous cell carcinoma.","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145814016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-20DOI: 10.1016/s1470-2045(25)00642-4
Anca-Ligia Grosu, Wolfgang A Weber, Erika Graf, Michael Mix, Ursula Nestle, Tanja Schimek-Jasch, Rolf Wiehle, Irina Mader, Urs Würtemberger, Karl-Josef Langen, Maximilian Niyazi, Frank Paulsen, Liane König, Frank Anton Giordano, Irina Spehl, Denise Bernhardt, Markus M Schymalla, Christoph Pöttgen, Sabine Semrau, Thomas Brunner, Beatrix Hültenschmidt, Bernd Joachim Krause, Ilja Frank Ciernik, Jürgen Beck, Brigitta G Baumert, Philipp T Meyer, Horst Urbach, Ilinca Popp, Claus Belka, Franziska Eckert, Michael J. Eble, Elena Sperk, Felix Momm, Stephanie E. Combs, Benedikt Wiestler, Rita Engenhart-Cabillic, Martin Stuschke, Rainer Fietkau, Stephan Nadji, Guido Hildebrandt, Arnab Chakravarti, Susan C. Short, Carsten Nieder, Sabine Schneider-Fuchs, Marco Prinz
{"title":"O-(2-[18F]fluoroethyl)-L-tyrosine-PET-guided versus contrast-enhanced T1-weighted MRI-guided re-irradiation in patients with recurrent glioblastoma (GLIAA/NOA-10 ARO2013-01): a multicentre, open-label, randomised trial","authors":"Anca-Ligia Grosu, Wolfgang A Weber, Erika Graf, Michael Mix, Ursula Nestle, Tanja Schimek-Jasch, Rolf Wiehle, Irina Mader, Urs Würtemberger, Karl-Josef Langen, Maximilian Niyazi, Frank Paulsen, Liane König, Frank Anton Giordano, Irina Spehl, Denise Bernhardt, Markus M Schymalla, Christoph Pöttgen, Sabine Semrau, Thomas Brunner, Beatrix Hültenschmidt, Bernd Joachim Krause, Ilja Frank Ciernik, Jürgen Beck, Brigitta G Baumert, Philipp T Meyer, Horst Urbach, Ilinca Popp, Claus Belka, Franziska Eckert, Michael J. Eble, Elena Sperk, Felix Momm, Stephanie E. Combs, Benedikt Wiestler, Rita Engenhart-Cabillic, Martin Stuschke, Rainer Fietkau, Stephan Nadji, Guido Hildebrandt, Arnab Chakravarti, Susan C. Short, Carsten Nieder, Sabine Schneider-Fuchs, Marco Prinz","doi":"10.1016/s1470-2045(25)00642-4","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00642-4","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"172 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/s1470-2045(25)00755-7
Manjulika Das
{"title":"Progress in global tobacco control measures","authors":"Manjulika Das","doi":"10.1016/s1470-2045(25)00755-7","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00755-7","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/s1470-2045(25)00754-5
Tony Kirby
{"title":"Donated sperm with TP53 mutation used to conceive at least 197 children","authors":"Tony Kirby","doi":"10.1016/s1470-2045(25)00754-5","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00754-5","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/s1470-2045(25)00753-3
Smriti Patodia
{"title":"San Antonio Breast Cancer Symposium 2025","authors":"Smriti Patodia","doi":"10.1016/s1470-2045(25)00753-3","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00753-3","url":null,"abstract":"","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1016/s1470-2045(25)00724-7
Talha Burki
No Abstract
没有抽象的
{"title":"UK Government launches first Men's Health Strategy","authors":"Talha Burki","doi":"10.1016/s1470-2045(25)00724-7","DOIUrl":"https://doi.org/10.1016/s1470-2045(25)00724-7","url":null,"abstract":"No Abstract","PeriodicalId":22865,"journal":{"name":"The Lancet Oncology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：