Han Jiang,Li Cheng,Tingjuan He,Chenchen Zhang,Birong Dong,He Cai,Tao Hu
BACKGROUNDIntrinsic capacity (IC) and oral health are crucial for healthy aging and are linked to future adverse health outcomes. Panoramic radiography provides comprehensive oral assessments and may have broader applications in health screening. However, the cross-sectional and longitudinal relationships between adverse oral conditions detected through panoramic radiographs and deficient IC remain insufficiently explored. Therefore, this study aimed to investigate these associations and explore the feasibility of panoramic radiography in primary health screening.METHODSData from the West China Health and Aging Trend study (2021-2024) were used. Adverse oral conditions (caries, residual roots, periodontitis, tooth loss, and functional impairments) were assessed by manual radiograph reading. IC levels were measured at each visit, encompassing locomotor, cognitive, psychological, vitality, and sensory functions. Cross-sectional analysis used logistic regression, and longitudinal analysis incorporated follow-up data via generalized estimating equations.RESULTSCross-sectional analysis showed that residual roots (odds ratio [OR] 2.28, 95% confidence interval [CI] 1.09-4.78), severe periodontitis (2.17, 1.00-4.68), missing teeth (2.57, 1.23-5.38), and >16 functional tooth loss (2.65, 1.15-6.09) were linked to deficient IC (n = 235). Longitudinal analysis confirmed associations of residual roots (-0.21, -0.42-0.00) and >16 functional tooth loss (-0.38, -0.73 to -0.02) with IC decline.CONCLUSIONSAdverse oral conditions were proved to have detrimental impact on IC among middle-aged and older adults, highlighting the potential of panoramic radiography as a valuable tool for early health screening in aging populations, as it may promote healthy aging and help mitigate health disparities.
{"title":"Applying Oral Panoramic Radiography to Health Screening of the Aging Population: Cross-sectional and Longitudinal Associations between Adverse Oral Conditions and Intrinsic Capacity Deficiency.","authors":"Han Jiang,Li Cheng,Tingjuan He,Chenchen Zhang,Birong Dong,He Cai,Tao Hu","doi":"10.1093/gerona/glaf180","DOIUrl":"https://doi.org/10.1093/gerona/glaf180","url":null,"abstract":"BACKGROUNDIntrinsic capacity (IC) and oral health are crucial for healthy aging and are linked to future adverse health outcomes. Panoramic radiography provides comprehensive oral assessments and may have broader applications in health screening. However, the cross-sectional and longitudinal relationships between adverse oral conditions detected through panoramic radiographs and deficient IC remain insufficiently explored. Therefore, this study aimed to investigate these associations and explore the feasibility of panoramic radiography in primary health screening.METHODSData from the West China Health and Aging Trend study (2021-2024) were used. Adverse oral conditions (caries, residual roots, periodontitis, tooth loss, and functional impairments) were assessed by manual radiograph reading. IC levels were measured at each visit, encompassing locomotor, cognitive, psychological, vitality, and sensory functions. Cross-sectional analysis used logistic regression, and longitudinal analysis incorporated follow-up data via generalized estimating equations.RESULTSCross-sectional analysis showed that residual roots (odds ratio [OR] 2.28, 95% confidence interval [CI] 1.09-4.78), severe periodontitis (2.17, 1.00-4.68), missing teeth (2.57, 1.23-5.38), and >16 functional tooth loss (2.65, 1.15-6.09) were linked to deficient IC (n = 235). Longitudinal analysis confirmed associations of residual roots (-0.21, -0.42-0.00) and >16 functional tooth loss (-0.38, -0.73 to -0.02) with IC decline.CONCLUSIONSAdverse oral conditions were proved to have detrimental impact on IC among middle-aged and older adults, highlighting the potential of panoramic radiography as a valuable tool for early health screening in aging populations, as it may promote healthy aging and help mitigate health disparities.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"179 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacqueline K Yuen,Rachelle Bernacki,Felix H W Chan,Tuen-Ching Chan,David T Y Chow,Yat-Fung Shea,Betty L H Ng,Karen M K Chan,Xue Li,Qi-Man Shi,James K H Luk
BACKGROUNDNasogastric tube feeding is commonly used for enteral nutrition in individuals with advanced dementia with feeding difficulties, but its impact on survival and pneumonia risk compared to careful hand feeding remains controversial. This study aimed to compare one-year survival and pneumonia risk in individuals with advanced dementia initiated on nasogastric tube feeding versus those receiving careful hand feeding.METHODSA prospective propensity score-matched cohort study was conducted. Participants included individuals aged ≥60 years with advanced dementia and feeding problems admitted to two geriatric hospitals between September 2020 and September 2022. Propensity-score matched cohorts were analyzed using Kaplan-Meier survival analysis and Cox proportional hazards regression models.RESULTSAmong 283 participants (mean age 89.8 years, 62.2% female, 73.5% residential care home residents), 184 (65.0%) were received careful hand feeding and 99 (35.0%) nasogastric tube feeding. A matched subsample of 176 participants (116 careful hand feeding, 60 nasogastric tube feeding) was analyzed. One-year adjusted survival did not differ significantly between the nasogastric tube feeding and careful hand feeding groups (AHR= 0.85, 95% CI, 0.59-1.23, P =.38). However, the nasogastric tube feeding group had a significantly higher one-year adjusted pneumonia risk compared to the careful hand feeding group (AHR 1.60, 95% CI, 1.06-2.42, P =.03).CONCLUSIONSIndividuals with advanced dementia initiated on nasogastric tube feeding do not have meaningfully improved survival and have a higher risk of pneumonia compared to those receiving careful hand feeding. These findings can guide clinicians and families when considering feeding tube placement for individuals with advanced dementia.
研究背景：鼻胃管喂养通常用于晚期痴呆患者的肠内营养，但与手喂相比，其对生存和肺炎风险的影响仍存在争议。本研究旨在比较晚期痴呆患者鼻胃管喂养与手喂的一年生存率和肺炎风险。方法采用前瞻性倾向评分匹配队列研究。参与者包括在2020年9月至2022年9月期间入住两家老年医院的年龄≥60岁的晚期痴呆患者和饮食问题患者。使用Kaplan-Meier生存分析和Cox比例风险回归模型对倾向评分匹配的队列进行分析。结果283例患者（平均年龄89.8岁，女性62.2%，居住在安老院中73.5%）中，184例（65.0%）采用精心手工喂养，99例（35.0%）采用鼻胃管喂养。分析了176名参与者的匹配子样本（116名小心手喂，60名鼻胃管喂）。鼻胃管喂养组和细心手喂组的1年调整生存率无显著差异（AHR= 0.85, 95% CI, 0.59-1.23, P = 0.38）。然而，鼻胃管喂养组的1年校正肺炎风险明显高于手动喂养组（AHR 1.60, 95% CI, 1.06-2.42, P = 0.03）。结论：与手饲相比，采用鼻胃管喂养的晚期痴呆患者的生存率并没有显著提高，而且患肺炎的风险更高。这些发现可以指导临床医生和家庭考虑为晚期痴呆患者放置饲管。
{"title":"Comparison of Survival and Pneumonia Risk in Advanced Dementia Patients on Nasogastric Tube Feeding versus Careful Hand Feeding.","authors":"Jacqueline K Yuen,Rachelle Bernacki,Felix H W Chan,Tuen-Ching Chan,David T Y Chow,Yat-Fung Shea,Betty L H Ng,Karen M K Chan,Xue Li,Qi-Man Shi,James K H Luk","doi":"10.1093/gerona/glaf165","DOIUrl":"https://doi.org/10.1093/gerona/glaf165","url":null,"abstract":"BACKGROUNDNasogastric tube feeding is commonly used for enteral nutrition in individuals with advanced dementia with feeding difficulties, but its impact on survival and pneumonia risk compared to careful hand feeding remains controversial. This study aimed to compare one-year survival and pneumonia risk in individuals with advanced dementia initiated on nasogastric tube feeding versus those receiving careful hand feeding.METHODSA prospective propensity score-matched cohort study was conducted. Participants included individuals aged ≥60 years with advanced dementia and feeding problems admitted to two geriatric hospitals between September 2020 and September 2022. Propensity-score matched cohorts were analyzed using Kaplan-Meier survival analysis and Cox proportional hazards regression models.RESULTSAmong 283 participants (mean age 89.8 years, 62.2% female, 73.5% residential care home residents), 184 (65.0%) were received careful hand feeding and 99 (35.0%) nasogastric tube feeding. A matched subsample of 176 participants (116 careful hand feeding, 60 nasogastric tube feeding) was analyzed. One-year adjusted survival did not differ significantly between the nasogastric tube feeding and careful hand feeding groups (AHR= 0.85, 95% CI, 0.59-1.23, P =.38). However, the nasogastric tube feeding group had a significantly higher one-year adjusted pneumonia risk compared to the careful hand feeding group (AHR 1.60, 95% CI, 1.06-2.42, P =.03).CONCLUSIONSIndividuals with advanced dementia initiated on nasogastric tube feeding do not have meaningfully improved survival and have a higher risk of pneumonia compared to those receiving careful hand feeding. These findings can guide clinicians and families when considering feeding tube placement for individuals with advanced dementia.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"739 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Intrinsic Capacity (IC) is a multidimensional construct defined by the World Health Organization (WHO). Although IC has been established as a significant predictor of functional decline in older adults, emerging evidence suggests that functional impairment may, in turn, accelerate the degradation of IC, indicating a potential bidirectional relationship. Therefore, this study aims to systematically examine the potential bidirectional relationship between IC and functional ability. Methods This study analyzed longitudinal data from 2,233 adults aged 60 and above from the China Health and Retirement Longitudinal Study (CHARLS, 2011-2015). Cross-lagged panel models (CLPM) and random-intercept cross-lagged panel models (RI-CLPM) were used to examine bidirectional associations between IC and functional ability. IC (0-100) was assessed across five domains: locomotion, cognition, psychological well-being, vitality, and sensory function. Functional ability was measured using scores for basic (BADL: 0-18) and instrumental (IADL: 0-15) activities of daily living at three time points. Models were adjusted for sociodemographic, health, and behavioral factors. Results Compared to CLPM, RI-CLPM better captured the dynamic trajectory of functional status in older adults. IC decline significantly predicted BADL deterioration (β = 0.089-0.109, p < 0.05), but BADL changes did not significantly affect IC. A bidirectional relationship existed between IC and IADL, with IC’s effect on IADL (β = 0.206-0.236, p < 0.001) being stronger than the reverse (β = 0.093-0.100, p < 0.001). Conclusions This study employed CLPM and RI-CLPM to investigate the dynamic relationship between IC and functional ability. These results offer new directions for developing interventions to promote healthy aging.
内在能力（IC）是世界卫生组织（WHO）定义的一个多维概念。虽然IC已被确定为老年人功能衰退的重要预测指标，但新出现的证据表明，功能损伤可能反过来加速IC的降解，表明潜在的双向关系。因此，本研究旨在系统地研究IC与功能能力之间潜在的双向关系。方法本研究分析了中国健康与退休纵向研究（CHARLS, 2011-2015）中2233名60岁及以上成年人的纵向数据。交叉滞后面板模型（CLPM）和随机截距交叉滞后面板模型（RI-CLPM）用于检验IC与功能能力之间的双向关联。IC（0-100）分为五个领域：运动、认知、心理健康、活力和感觉功能。功能能力采用基本（BADL: 0-18）和工具性（IADL: 0-15）日常生活活动在三个时间点的得分进行测量。模型根据社会人口、健康和行为因素进行了调整。结果与CLPM相比，RI-CLPM能更好地捕捉老年人功能状态的动态轨迹。IC下降可显著预测BADL恶化(β = 0.089-0.109, p <；0.05)，但BADL的变化对IC无显著影响。IC与IADL呈双向关系，IC对IADL有影响(β = 0.206-0.236, p <；0.001)比相反(β = 0.093-0.100, p <；0.001)。结论本研究采用CLPM和RI-CLPM研究IC与功能能力的动态关系。这些结果为制定促进健康老龄化的干预措施提供了新的方向。
{"title":"The Longitudinal Association Between Intrinsic Capacity and Functional Ability in Older Adults: Comparing Findings from the Cross-Lagged Panel Model and the Random-Intercept Cross-Lagged Panel Model","authors":"Yilin Cheng, Shuqin Xiao, Yurun Cai, Liwei Jing, Weiyao Li, Xue Liu","doi":"10.1093/gerona/glaf172","DOIUrl":"https://doi.org/10.1093/gerona/glaf172","url":null,"abstract":"Background Intrinsic Capacity (IC) is a multidimensional construct defined by the World Health Organization (WHO). Although IC has been established as a significant predictor of functional decline in older adults, emerging evidence suggests that functional impairment may, in turn, accelerate the degradation of IC, indicating a potential bidirectional relationship. Therefore, this study aims to systematically examine the potential bidirectional relationship between IC and functional ability. Methods This study analyzed longitudinal data from 2,233 adults aged 60 and above from the China Health and Retirement Longitudinal Study (CHARLS, 2011-2015). Cross-lagged panel models (CLPM) and random-intercept cross-lagged panel models (RI-CLPM) were used to examine bidirectional associations between IC and functional ability. IC (0-100) was assessed across five domains: locomotion, cognition, psychological well-being, vitality, and sensory function. Functional ability was measured using scores for basic (BADL: 0-18) and instrumental (IADL: 0-15) activities of daily living at three time points. Models were adjusted for sociodemographic, health, and behavioral factors. Results Compared to CLPM, RI-CLPM better captured the dynamic trajectory of functional status in older adults. IC decline significantly predicted BADL deterioration (β = 0.089-0.109, p &lt; 0.05), but BADL changes did not significantly affect IC. A bidirectional relationship existed between IC and IADL, with IC’s effect on IADL (β = 0.206-0.236, p &lt; 0.001) being stronger than the reverse (β = 0.093-0.100, p &lt; 0.001). Conclusions This study employed CLPM and RI-CLPM to investigate the dynamic relationship between IC and functional ability. These results offer new directions for developing interventions to promote healthy aging.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guillaume Provost,Kamaryn Tanner,Véronique Legault,Luigi Ferrucci,Stefania Bandinelli,Linda P Fried,Daniel W Belsky,Benoit Laurent,Alan A Cohen
Aging is the leading risk factor for most chronic disease. However, disease risk varies substantially between individuals of the same age. Biological aging measures attempt to quantify this difference using biomarkers; such measures have amassed substantial evidence as reliable correlates of morbidity and mortality. Although many have been developed throughout the years, there is no clear consensus as to which one is the best, if any. This study evaluates four methods for measuring biological aging: Klemera and Doubal's method for biological age (KDM BA), phenotypic age (PA), homeostatic dysregulation (DM), and Pace of Aging (Pace). Using five cohort studies from four different countries (InCHIANTI from Italy, WHAS I and II from the US, NuAge from Canada, and the UK Biobank), we assessed the relationship of these metrics with six health outcomes. The metrics were calculated using a consistent set of biomarkers to facilitate comparison. The biological aging measures correlated only weakly with each other (r > 0.5 for six of 21 correlations). The meta-analyses performed on the results from each dataset revealed that all biological age measures were significantly associated with at least one health outcome; however, no single metric consistently outperformed the others, with strength of association strikingly similar across metrics. This study is the first to combine an international multi-cohort analysis using a consistent set of biomarkers across biological age metrics. While there are no net winners or losers, effect sizes are heterogeneous across cohorts, highlighting the importance of replicating findings in different contexts and with different metrics.
{"title":"No winners or losers: clinical chemistry-based biological aging metrics perform similarly across cohorts and health outcomes.","authors":"Guillaume Provost,Kamaryn Tanner,Véronique Legault,Luigi Ferrucci,Stefania Bandinelli,Linda P Fried,Daniel W Belsky,Benoit Laurent,Alan A Cohen","doi":"10.1093/gerona/glaf179","DOIUrl":"https://doi.org/10.1093/gerona/glaf179","url":null,"abstract":"Aging is the leading risk factor for most chronic disease. However, disease risk varies substantially between individuals of the same age. Biological aging measures attempt to quantify this difference using biomarkers; such measures have amassed substantial evidence as reliable correlates of morbidity and mortality. Although many have been developed throughout the years, there is no clear consensus as to which one is the best, if any. This study evaluates four methods for measuring biological aging: Klemera and Doubal's method for biological age (KDM BA), phenotypic age (PA), homeostatic dysregulation (DM), and Pace of Aging (Pace). Using five cohort studies from four different countries (InCHIANTI from Italy, WHAS I and II from the US, NuAge from Canada, and the UK Biobank), we assessed the relationship of these metrics with six health outcomes. The metrics were calculated using a consistent set of biomarkers to facilitate comparison. The biological aging measures correlated only weakly with each other (r > 0.5 for six of 21 correlations). The meta-analyses performed on the results from each dataset revealed that all biological age measures were significantly associated with at least one health outcome; however, no single metric consistently outperformed the others, with strength of association strikingly similar across metrics. This study is the first to combine an international multi-cohort analysis using a consistent set of biomarkers across biological age metrics. While there are no net winners or losers, effect sizes are heterogeneous across cohorts, highlighting the importance of replicating findings in different contexts and with different metrics.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peng Wang, Yiming Wang, Ping Xiang, Binyu Bai, Biao Xie, Dan Shi
BACKGROUND The associations of macronutrient intake with accelerated biological aging and life expectancy remain unclear. METHODS In total, 56,555 participants in the UK Biobank were included. Macronutrient intake patterns, including overall low-carbohydrate-diet (LCD), low-fat-diet (LFD), low-protein-diet (LPD), low-animal-protein diet (LAPD), low-vegetable-protein diet (LVPD), low-animal-fat diet (LAFD), low-vegetable-fat diet (LVFD), and healthful plant-based diet index (hPDI), were assessed via the Oxford WebQ. Klemera-Doubal-Method Biological Age acceleration (KDM-BA Accel) and PhenoAge acceleration (PhenoAge Accel) were computed to assess accelerated biological aging. Multivariable generalized linear regressions were conducted to estimate the β and 95% confidence intervals (CI). Life expectancy was assessed by proportional hazards survival analysis. RESULTS We observed consistent significant associations of overall LCD and LFD, but not LPD, with biological aging. However, overall macronutrient intake patterns were not related to life expectancy. Compared with the lowest tertile, adherence to the LLQCD, LAPD, LAFD and hPDI in the highest tertile were associated with decreases of -0.901 (95% CI: -1.025, -0.778), -0.762 (-0.888, -0.637), -0.996 (-1.121, -0.870), and -0.113 (-0.127, -0.099) KDM-BA-Accel years, and -0.847 (-0.933, -0.761), -0.497 (-0.585, -0.409), -0.950 (-1.038, -0.863), and -0.221 (-0.241, -0.200) PhenoAge-Accel years, as well as additional gains of 1.666 (1.039, 2.294), 1.538 (0.912, 2.164), 1.381 (0.757, 2.006), and 2.650 (2.007, 3.292) life years, respectively. Conversely, LHQCD, LVPD, and LVFD were associated with accelerated biological aging and shorten life expectancy. CONCLUSIONS This study demonstrates that the quality of macronutrient intake patterns may be more important than overall patterns in influencing biological aging and life expectancy.
{"title":"Associations of macronutrient intake patterns with accelerated biological ageing and life expectancy: Evidence from a population-based study in the UK Biobank","authors":"Peng Wang, Yiming Wang, Ping Xiang, Binyu Bai, Biao Xie, Dan Shi","doi":"10.1093/gerona/glaf175","DOIUrl":"https://doi.org/10.1093/gerona/glaf175","url":null,"abstract":"BACKGROUND The associations of macronutrient intake with accelerated biological aging and life expectancy remain unclear. METHODS In total, 56,555 participants in the UK Biobank were included. Macronutrient intake patterns, including overall low-carbohydrate-diet (LCD), low-fat-diet (LFD), low-protein-diet (LPD), low-animal-protein diet (LAPD), low-vegetable-protein diet (LVPD), low-animal-fat diet (LAFD), low-vegetable-fat diet (LVFD), and healthful plant-based diet index (hPDI), were assessed via the Oxford WebQ. Klemera-Doubal-Method Biological Age acceleration (KDM-BA Accel) and PhenoAge acceleration (PhenoAge Accel) were computed to assess accelerated biological aging. Multivariable generalized linear regressions were conducted to estimate the β and 95% confidence intervals (CI). Life expectancy was assessed by proportional hazards survival analysis. RESULTS We observed consistent significant associations of overall LCD and LFD, but not LPD, with biological aging. However, overall macronutrient intake patterns were not related to life expectancy. Compared with the lowest tertile, adherence to the LLQCD, LAPD, LAFD and hPDI in the highest tertile were associated with decreases of -0.901 (95% CI: -1.025, -0.778), -0.762 (-0.888, -0.637), -0.996 (-1.121, -0.870), and -0.113 (-0.127, -0.099) KDM-BA-Accel years, and -0.847 (-0.933, -0.761), -0.497 (-0.585, -0.409), -0.950 (-1.038, -0.863), and -0.221 (-0.241, -0.200) PhenoAge-Accel years, as well as additional gains of 1.666 (1.039, 2.294), 1.538 (0.912, 2.164), 1.381 (0.757, 2.006), and 2.650 (2.007, 3.292) life years, respectively. Conversely, LHQCD, LVPD, and LVFD were associated with accelerated biological aging and shorten life expectancy. CONCLUSIONS This study demonstrates that the quality of macronutrient intake patterns may be more important than overall patterns in influencing biological aging and life expectancy.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Golam Rabbani,Sheikh M Alif,Zhen Zhou,Joanne Ryan,Nazmul Karim
BACKGROUNDSerum uric acid (SUA) levels may be associated with cognitive function, but findings have been inconsistent, potentially varying by cognitive domain and sex. We aimed to determine the association of SUA and different domains of cognitive function.METHODSFive electronic databases were searched to identify relevant peer-reviewed articles. Studies investigating the association between SUA levels and cognitive function were included. Standardised mean difference (SMD) was calculated and separate meta-analyses were conducted for each of the domains. Risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale. Between-study heterogeneity was investigated through subgroup analysis and a meta-regression model using study-level covariates.RESULTSTen prospective cohort and sixteen cross-sectional studies were eligible for inclusion, but only a subset of these studies was included in each meta-analysis. Pooled estimates from cross-sectional studies showed that higher SUA levels were significantly associated with better global cognition (n = 6, SMD = 2.27, 95%CI:1.18-3.35), and learning and memory (n = 4, SMD = 1.49, 95%CI:1.12-1.87). Sensitivity analysis, excluding the study conducted on amyotrophic lateral sclerosis (ALS) patients, resulted in better performance estimates for executive function (n = 4, SMD = 0.51, 95%CI:0.47-0.55) and language (n = 2, SMD = 0.75, 95%CI:0.71-0.79). The pooled result from two prospective cohort studies found a positive relationship between SUA levels and attention (SMD = 0.22, 95%CI:0.07-0.36). SUA levels were associated with executive function and learning and memory in males, and with language in females.CONCLUSIONSHigher SUA levels were associated with better global cognitive performance executive function, learning and memory, attention and language. These findings highlight low SUA levels as a potential useful biomarker for cognitive decline.
{"title":"Association between higher serum uric acid levels and cognitive function: a systematic review and meta-analysis.","authors":"Golam Rabbani,Sheikh M Alif,Zhen Zhou,Joanne Ryan,Nazmul Karim","doi":"10.1093/gerona/glaf174","DOIUrl":"https://doi.org/10.1093/gerona/glaf174","url":null,"abstract":"BACKGROUNDSerum uric acid (SUA) levels may be associated with cognitive function, but findings have been inconsistent, potentially varying by cognitive domain and sex. We aimed to determine the association of SUA and different domains of cognitive function.METHODSFive electronic databases were searched to identify relevant peer-reviewed articles. Studies investigating the association between SUA levels and cognitive function were included. Standardised mean difference (SMD) was calculated and separate meta-analyses were conducted for each of the domains. Risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale. Between-study heterogeneity was investigated through subgroup analysis and a meta-regression model using study-level covariates.RESULTSTen prospective cohort and sixteen cross-sectional studies were eligible for inclusion, but only a subset of these studies was included in each meta-analysis. Pooled estimates from cross-sectional studies showed that higher SUA levels were significantly associated with better global cognition (n = 6, SMD = 2.27, 95%CI:1.18-3.35), and learning and memory (n = 4, SMD = 1.49, 95%CI:1.12-1.87). Sensitivity analysis, excluding the study conducted on amyotrophic lateral sclerosis (ALS) patients, resulted in better performance estimates for executive function (n = 4, SMD = 0.51, 95%CI:0.47-0.55) and language (n = 2, SMD = 0.75, 95%CI:0.71-0.79). The pooled result from two prospective cohort studies found a positive relationship between SUA levels and attention (SMD = 0.22, 95%CI:0.07-0.36). SUA levels were associated with executive function and learning and memory in males, and with language in females.CONCLUSIONSHigher SUA levels were associated with better global cognitive performance executive function, learning and memory, attention and language. These findings highlight low SUA levels as a potential useful biomarker for cognitive decline.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUNDThe glymphatic system is a crucial pathway for the clearance of metabolic waste in the central nervous system. However, the risk factors of glymphatic system such as age, gender, metabolic factors, cardiovascular disease and lifestyle are not fully investigated. We examined the association between risk factors and glymphatic system to identify the key factors that influence glymphatic system in older adults.METHODSA total of 228 community-dwelling participants aged 40-82 years were assessed with 3T MRI. MRI measures, including perivascular space (PVS) volume fraction (PVSVF), free water (FW), and diffusion tensor image analysis along the perivascular space (DTI-ALPS) were calculated. The participants were divided into three subgroups by age including 40-54 years (n = 88), 55-64 years (n = 83), and ≥65 years group (n = 34). The association between age and glymphatic system was analyzed using linear regression model.RESULTSIn total, 205 participants aged from 40 to 82 years were analyzed. FW in white matter (β = 0.308, p = 0.020) and DTI-ALPS (β=-0.356, p = 0.001) were associated with age significantly. In subgroup, FW in white matter (β = 0.732, p < 0.001) positively correlated with age in ≥ 65 years group. DTI-ALPS negatively correlated with age in ≥ 65 years group (β=-0.532, p = 0.001) after including fractional anisotropy (FA) and mean diffusivity (MD) of interest region as covariates.DISCUSSIONAging was found to be a key factor influencing the function of the glymphatic system especially in the participants during older age (≥ 65 years), suggesting the potential importance of the sixth decade for early preservation methods of the glymphatic system.
淋巴系统是清除中枢神经系统代谢废物的重要途径。然而，淋巴系统的危险因素如年龄、性别、代谢因素、心血管疾病和生活方式等尚未得到充分的研究。我们检查了危险因素与淋巴系统之间的关系，以确定影响老年人淋巴系统的关键因素。方法对228名40 ~ 82岁的社区居民进行3T MRI评估。计算MRI测量，包括血管周围空间（PVS）体积分数（PVSVF）、游离水（FW）和沿血管周围空间的扩散张量图像分析（DTI-ALPS）。参与者按年龄分为40-54岁组（n = 88）、55-64岁组（n = 83）和≥65岁组（n = 34）。采用线性回归模型分析年龄与淋巴系统的关系。结果共纳入205例受试者，年龄40 ~ 82岁。脑白质FW （β= 0.308, p = 0.020）和DTI-ALPS （β=-0.356, p = 0.001）与年龄显著相关。在亚组中，≥65岁组脑白质FW与年龄呈正相关（β = 0.732, p < 0.001）。以分数各向异性（FA）和平均扩散率（MD）为协变量后，≥65岁组DTI-ALPS与年龄呈负相关（β=-0.532, p = 0.001）。研究发现，衰老是影响淋巴系统功能的一个关键因素，尤其是在年龄较大（≥65岁）的参与者中，这提示了60岁对早期保存淋巴系统方法的潜在重要性。
{"title":"Aging as a Key Determinant of Glymphatic System Function in older adults.","authors":"Feiyue Yin,Bang Zeng,Lisha Nie,Shuang Ding,Dan Luo,Peng Zeng,Binglan Li,Zhuowei Shi,Yongmei Li,Tianyou Luo","doi":"10.1093/gerona/glaf176","DOIUrl":"https://doi.org/10.1093/gerona/glaf176","url":null,"abstract":"BACKGROUNDThe glymphatic system is a crucial pathway for the clearance of metabolic waste in the central nervous system. However, the risk factors of glymphatic system such as age, gender, metabolic factors, cardiovascular disease and lifestyle are not fully investigated. We examined the association between risk factors and glymphatic system to identify the key factors that influence glymphatic system in older adults.METHODSA total of 228 community-dwelling participants aged 40-82 years were assessed with 3T MRI. MRI measures, including perivascular space (PVS) volume fraction (PVSVF), free water (FW), and diffusion tensor image analysis along the perivascular space (DTI-ALPS) were calculated. The participants were divided into three subgroups by age including 40-54 years (n = 88), 55-64 years (n = 83), and ≥65 years group (n = 34). The association between age and glymphatic system was analyzed using linear regression model.RESULTSIn total, 205 participants aged from 40 to 82 years were analyzed. FW in white matter (β = 0.308, p = 0.020) and DTI-ALPS (β=-0.356, p = 0.001) were associated with age significantly. In subgroup, FW in white matter (β = 0.732, p < 0.001) positively correlated with age in ≥ 65 years group. DTI-ALPS negatively correlated with age in ≥ 65 years group (β=-0.532, p = 0.001) after including fractional anisotropy (FA) and mean diffusivity (MD) of interest region as covariates.DISCUSSIONAging was found to be a key factor influencing the function of the glymphatic system especially in the participants during older age (≥ 65 years), suggesting the potential importance of the sixth decade for early preservation methods of the glymphatic system.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Methionine restriction (MR) has many effects on different molecular and physiological systems and pathways associated with aging. However, these outcomes have often been ambiguous across studies, suggesting context of outcomes, including tissue type or donor sex, may have significant impact. We have previously shown that methionine sulfoxide reductase A (MsrA) may have discrete roles on aging physiology under methionine restriction. Here we investigated the effect of MR on putative molecular hallmarks of aging, including mitochondrial function and regulation of the intracellular signal hydrogen sulfide, across tissues and in males and females. We found that females tended to have greater changes to mitochondrial oxygen consumption than males with MR, while the effects of MsrA were context dependent. Mitochondrial hydrogen peroxide production was decreased by MR in hepatic mitochondria from females and only slightly higher with loss of MsrA in both sexes. In contrast, mitochondrial peroxide production was increased in the kidney with MR regardless of sex or MsrA status. Hydrogen sulfide production capacity was increased only in the liver by MR independent of MsrA, though expression of regulators of hydrogen sulfide generation were changed in a tissue-dependent manner that was not altered by MsrA status. Expression of methionine sulfoxide reductases were also impacted by MR showing changes in expression in a tissue and sex dependent manner. These results suggest a complex interaction between tissue, sex, diet, and MsrA status.
{"title":"Tissue-specific molecular regulation of aging mechanisms with methionine restriction in mice and the potential role of methionine sulfoxide reductase.","authors":"Kevin M Thyne,Raechel Camones,Adam B Salmon","doi":"10.1093/gerona/glaf177","DOIUrl":"https://doi.org/10.1093/gerona/glaf177","url":null,"abstract":"Methionine restriction (MR) has many effects on different molecular and physiological systems and pathways associated with aging. However, these outcomes have often been ambiguous across studies, suggesting context of outcomes, including tissue type or donor sex, may have significant impact. We have previously shown that methionine sulfoxide reductase A (MsrA) may have discrete roles on aging physiology under methionine restriction. Here we investigated the effect of MR on putative molecular hallmarks of aging, including mitochondrial function and regulation of the intracellular signal hydrogen sulfide, across tissues and in males and females. We found that females tended to have greater changes to mitochondrial oxygen consumption than males with MR, while the effects of MsrA were context dependent. Mitochondrial hydrogen peroxide production was decreased by MR in hepatic mitochondria from females and only slightly higher with loss of MsrA in both sexes. In contrast, mitochondrial peroxide production was increased in the kidney with MR regardless of sex or MsrA status. Hydrogen sulfide production capacity was increased only in the liver by MR independent of MsrA, though expression of regulators of hydrogen sulfide generation were changed in a tissue-dependent manner that was not altered by MsrA status. Expression of methionine sulfoxide reductases were also impacted by MR showing changes in expression in a tissue and sex dependent manner. These results suggest a complex interaction between tissue, sex, diet, and MsrA status.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background In the context of climate change, tropical cyclones (TCs) pose an escalating threat to human health. This study examined the effects of TCs on cognitive function of older adults in Thailand and explored underlying mechanisms. Methods Data came from two sources: the Health, Aging and Retirement in Thailand (HART) survey and Emergency Events Database (EM-DAT). The two datasets were matched to estimate the short- and long-term effects of TC exposure on cognition using fixed-effects model. Cognition of older adults was assessed along three dimensions: memory, calculation, and time orientation. Depression, hypertension, and social isolation were examined as potential underlying mechanisms. Results Analyses found that exposure to TCs had a persistent negative effect on the calculation dimension, while its effects on memory and time orientation were minimal or short-lived. Specifically, exposed individuals had significantly lower calculation scores compared to unexposed individuals on the day of exposure, and this negative effect persisted for up to four years. An increased likelihood of depression, exacerbation of existing hypertension, and reduced engagement in social activities were found to help explain the effects of TCs on cognition. Conclusions The study provided evidence of the detrimental effects of TCs on specific cognitive domains in older adults, identifying depression, exacerbation of hypertension, and social isolation identified as underlying mechanisms. The findings underscored the need for further research on the cognitive impact of TCs in the aging population, and the development of practice and policy interventions to mitigate these effects.
{"title":"The effect of tropical cyclone on cognitive function in older adults: A longitudinal study from Thailand","authors":"Jin Ke, Fei Sun, Phatchanun Vivarakanon","doi":"10.1093/gerona/glaf169","DOIUrl":"https://doi.org/10.1093/gerona/glaf169","url":null,"abstract":"Background In the context of climate change, tropical cyclones (TCs) pose an escalating threat to human health. This study examined the effects of TCs on cognitive function of older adults in Thailand and explored underlying mechanisms. Methods Data came from two sources: the Health, Aging and Retirement in Thailand (HART) survey and Emergency Events Database (EM-DAT). The two datasets were matched to estimate the short- and long-term effects of TC exposure on cognition using fixed-effects model. Cognition of older adults was assessed along three dimensions: memory, calculation, and time orientation. Depression, hypertension, and social isolation were examined as potential underlying mechanisms. Results Analyses found that exposure to TCs had a persistent negative effect on the calculation dimension, while its effects on memory and time orientation were minimal or short-lived. Specifically, exposed individuals had significantly lower calculation scores compared to unexposed individuals on the day of exposure, and this negative effect persisted for up to four years. An increased likelihood of depression, exacerbation of existing hypertension, and reduced engagement in social activities were found to help explain the effects of TCs on cognition. Conclusions The study provided evidence of the detrimental effects of TCs on specific cognitive domains in older adults, identifying depression, exacerbation of hypertension, and social isolation identified as underlying mechanisms. The findings underscored the need for further research on the cognitive impact of TCs in the aging population, and the development of practice and policy interventions to mitigate these effects.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"130 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisa Fabbri, Julián Candia, Toshiko Tanaka, Ann Zenobia Moore, Paolo Muratori, Agar Brugiavini, Amaia Calderón-Larrañaga, Davide L Vetrano, Laura Fratiglioni, Eileen Crimmins, Jessica Faul, Kenneth M Langa, David Weir, Luigi Ferrucci
Introduction Life expectancy has increased, but such increase has disproportionally expanded the period of life with diseases. Whether expanding health expectancy (HE), defined as years of life free of chronic diseases, could also affect rate of multimorbidity accumulation is uncertain. Objective: to investigate the dynamic relationship between HE and rate of multimorbidity accumulation and their impact on survival. Methods 4274 (3511 > 50 years) participants from the Health and Retirement Study (HRS), healthy at baseline and developing at least one disease overtime were included. Mean baseline age was 55.1 years and average follow-up was 9.4 years. Multimorbidity was operationalized as count of diagnosed diseases from a list of nine chronic conditions. HE was operationalized as years from birth until when the first disease was ascertained, and percentage of life in good health calculated as percentage of life lived free of chronic diseases. Mixed models investigated the association between HE and rate of multimorbidity accumulation, while survival analyses evaluated association with time to death. Results HE were positively associated with multimorbidity rate (P<.001). Shorter HE and faster multimorbidity rate were independently associated with higher mortality (P<.001). Their interaction was negatively associated with mortality (P<.001). Results were confirmed restricting the analysis to individuals 51 or older and using HRS specific weights. Individuals with longer HE experienced a greater survival, almost regardless of multimorbidity rate, while a positive gradient was found in percentage of life in good health linked to multimorbidity rate. Discussion Expanding health expectancy is likely followed by compression of morbidity.
{"title":"Dynamics of Multimorbidity, Health Expectancy and Survival in Middle Aged and Older Individuals","authors":"Elisa Fabbri, Julián Candia, Toshiko Tanaka, Ann Zenobia Moore, Paolo Muratori, Agar Brugiavini, Amaia Calderón-Larrañaga, Davide L Vetrano, Laura Fratiglioni, Eileen Crimmins, Jessica Faul, Kenneth M Langa, David Weir, Luigi Ferrucci","doi":"10.1093/gerona/glaf164","DOIUrl":"https://doi.org/10.1093/gerona/glaf164","url":null,"abstract":"Introduction Life expectancy has increased, but such increase has disproportionally expanded the period of life with diseases. Whether expanding health expectancy (HE), defined as years of life free of chronic diseases, could also affect rate of multimorbidity accumulation is uncertain. Objective: to investigate the dynamic relationship between HE and rate of multimorbidity accumulation and their impact on survival. Methods 4274 (3511 &gt; 50 years) participants from the Health and Retirement Study (HRS), healthy at baseline and developing at least one disease overtime were included. Mean baseline age was 55.1 years and average follow-up was 9.4 years. Multimorbidity was operationalized as count of diagnosed diseases from a list of nine chronic conditions. HE was operationalized as years from birth until when the first disease was ascertained, and percentage of life in good health calculated as percentage of life lived free of chronic diseases. Mixed models investigated the association between HE and rate of multimorbidity accumulation, while survival analyses evaluated association with time to death. Results HE were positively associated with multimorbidity rate (P&lt;.001). Shorter HE and faster multimorbidity rate were independently associated with higher mortality (P&lt;.001). Their interaction was negatively associated with mortality (P&lt;.001). Results were confirmed restricting the analysis to individuals 51 or older and using HRS specific weights. Individuals with longer HE experienced a greater survival, almost regardless of multimorbidity rate, while a positive gradient was found in percentage of life in good health linked to multimorbidity rate. Discussion Expanding health expectancy is likely followed by compression of morbidity.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"215 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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