{"title":"Intravenous tenecteplase for acute ischaemic stroke within 24 h due to basilar artery occlusion","authors":"Georgios Tsivgoulis, Lina Palaiodimou, Guillaume Turc","doi":"10.1016/s0140-6736(26)00139-x","DOIUrl":"https://doi.org/10.1016/s0140-6736(26)00139-x","url":null,"abstract":"","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-06DOI: 10.1016/s0140-6736(26)00036-x
Prihatha R Narasimmaraj, Yunzhe Qian, Jose F Figueroa, Sara N Bleich, Rishi K Wadhera
{"title":"Health effects of reductions in food assistance benefits in the USA","authors":"Prihatha R Narasimmaraj, Yunzhe Qian, Jose F Figueroa, Sara N Bleich, Rishi K Wadhera","doi":"10.1016/s0140-6736(26)00036-x","DOIUrl":"https://doi.org/10.1016/s0140-6736(26)00036-x","url":null,"abstract":"","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-06DOI: 10.1016/s0140-6736(26)00219-9
Minghui Ren, Yangmu Huang, Christopher Dowson, Ming Xu, Lewis Husain
{"title":"New approaches for UK–China global health cooperation","authors":"Minghui Ren, Yangmu Huang, Christopher Dowson, Ming Xu, Lewis Husain","doi":"10.1016/s0140-6736(26)00219-9","DOIUrl":"https://doi.org/10.1016/s0140-6736(26)00219-9","url":null,"abstract":"","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1016/s0140-6736(25)02276-7
Mazen Noureddin, Kris V Kowdley, Tatjana Odrljin, Gerard Bain, Jeff Zhao, Brenda Jeglinski, Margaret James Koziel, Rohit Loomba
{"title":"Efimosfermin alfa (BOS-580) once per month in people with metabolic dysfunction-associated steatohepatitis with F2 or F3 fibrosis: results from a 24-week, randomised, double-blind, placebo-controlled, phase 2 trial","authors":"Mazen Noureddin, Kris V Kowdley, Tatjana Odrljin, Gerard Bain, Jeff Zhao, Brenda Jeglinski, Margaret James Koziel, Rohit Loomba","doi":"10.1016/s0140-6736(25)02276-7","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)02276-7","url":null,"abstract":"","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"185 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1016/s0140-6736(25)01945-2
Chloe Orkin, Rosie Mngqibisa, Juan Diego Velez, Princy Kumar, Dominique L Braun, Andrew Carr, Mark Bloch, Sharon Walmsley, Pablo Tebas, Yoshiyuki Yokomaku, Tracy L Diamond, Beth Jackson, Karen Eves, Anjana Grandhi, Monica Fuszard, Stephanie O Klopfer, Luisa M Stamm, Michelle C Fox, Jason Kim
{"title":"Switch to fixed-dose doravirine (100 mg) and islatravir (0·25 mg) once daily in virologically suppressed adults with HIV-1 on oral antiretroviral therapy: 48-week results of a phase 3, multicentre, randomised, open-label, non-inferiority trial","authors":"Chloe Orkin, Rosie Mngqibisa, Juan Diego Velez, Princy Kumar, Dominique L Braun, Andrew Carr, Mark Bloch, Sharon Walmsley, Pablo Tebas, Yoshiyuki Yokomaku, Tracy L Diamond, Beth Jackson, Karen Eves, Anjana Grandhi, Monica Fuszard, Stephanie O Klopfer, Luisa M Stamm, Michelle C Fox, Jason Kim","doi":"10.1016/s0140-6736(25)01945-2","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01945-2","url":null,"abstract":"","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1016/s0140-6736(25)01632-0
Teba Alnima, Mark M Smits
No Abstract
没有抽象的
{"title":"Response to STRIDE: semaglutide in peripheral artery disease and type 2 diabetes","authors":"Teba Alnima, Mark M Smits","doi":"10.1016/s0140-6736(25)01632-0","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01632-0","url":null,"abstract":"No Abstract","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1016/s0140-6736(25)01578-8
<h3>Background</h3>Statin product labels (eg, Summaries of Product Characteristics [SmPCs]) list certain adverse outcomes as potential treatment-related effects based mainly on non-randomised and non-blinded studies, which might be subject to bias. We aimed to assess the evidence for such undesirable effects more reliably through a meta-analysis of individual participant data from large double-blind trials of statin therapy.<h3>Methods</h3>In this meta-analysis of individual participant-level data from double-blind randomised controlled trials, we generated a list of all undesirable effect terms listed in statin SmPCs by searching an electronic medicines compendium for five statins (atorvastatin, fluvastatin, pravastatin, rosuvastatin, and simvastatin). Randomised trials were eligible for meta-analysis of these effects if they involved at least 1000 participants, had a scheduled treatment period of at least 2 years, and involved a double-blind comparison of statin versus placebo or of a more intensive versus a less intensive statin regimen. Event rate ratios (RRs) and 95% CIs were calculated with statistical significance assessed after controlling the false discovery rate (FDR) at 5%.<h3>Findings</h3>19 trials compared statin versus placebo (123 940 participants, median follow-up 4·5 years [IQR 3·1–5·4]). In addition to previously reported effects on muscle outcomes and diabetes, only four of 66 further undesirable outcomes that had been attributed to statins were FDR significant: abnormal liver transaminases (783 participants [0·30% per annum] allocated statin <em>vs</em> 556 [0·22% per annum] allocated placebo, RR 1·41 [95% CI 1·26–1·57]) and other liver function test abnormalities (651 participants [0·25% per annum] allocated statin <em>vs</em> 518 [0·20% per annum] allocated placebo, RR 1·26 [1·12–1·41]; absolute annual excess of 0·13% for combined liver function test abnormality), urinary composition alteration (556 [0·21% per annum] allocated statin <em>vs</em> 472 [0·18% per annum] allocated placebo, RR 1·18 [1·04–1·33]), and oedema (3495 [1·38% per annum] allocated statin <em>vs</em> 3299 [1·31% per annum] allocated placebo, RR 1·07 [1·02–1·12]). Analysis of the four trials of more intensive versus less intensive statin regimens also found significant excesses for abnormal liver transaminases and other liver function test abnormalities (supporting a dose-dependent effect), but no significant excess was found for urinary composition alteration or oedema.<h3>Interpretation</h3>Adverse event data from blinded randomised trials do not support causal relationships between statin therapy and most of the conditions (including cognitive impairment, depression, sleep disturbance, and peripheral neuropathy) listed in product labels as potential undesirable effects. In light of these findings, such labelling and other official sources of health information should be revised so that patients and their doctors can make appropriately informed decisions
{"title":"Assessment of adverse effects attributed to statin therapy in product labels: a meta-analysis of double-blind randomised controlled trials","authors":"","doi":"10.1016/s0140-6736(25)01578-8","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01578-8","url":null,"abstract":"<h3>Background</h3>Statin product labels (eg, Summaries of Product Characteristics [SmPCs]) list certain adverse outcomes as potential treatment-related effects based mainly on non-randomised and non-blinded studies, which might be subject to bias. We aimed to assess the evidence for such undesirable effects more reliably through a meta-analysis of individual participant data from large double-blind trials of statin therapy.<h3>Methods</h3>In this meta-analysis of individual participant-level data from double-blind randomised controlled trials, we generated a list of all undesirable effect terms listed in statin SmPCs by searching an electronic medicines compendium for five statins (atorvastatin, fluvastatin, pravastatin, rosuvastatin, and simvastatin). Randomised trials were eligible for meta-analysis of these effects if they involved at least 1000 participants, had a scheduled treatment period of at least 2 years, and involved a double-blind comparison of statin versus placebo or of a more intensive versus a less intensive statin regimen. Event rate ratios (RRs) and 95% CIs were calculated with statistical significance assessed after controlling the false discovery rate (FDR) at 5%.<h3>Findings</h3>19 trials compared statin versus placebo (123 940 participants, median follow-up 4·5 years [IQR 3·1–5·4]). In addition to previously reported effects on muscle outcomes and diabetes, only four of 66 further undesirable outcomes that had been attributed to statins were FDR significant: abnormal liver transaminases (783 participants [0·30% per annum] allocated statin <em>vs</em> 556 [0·22% per annum] allocated placebo, RR 1·41 [95% CI 1·26–1·57]) and other liver function test abnormalities (651 participants [0·25% per annum] allocated statin <em>vs</em> 518 [0·20% per annum] allocated placebo, RR 1·26 [1·12–1·41]; absolute annual excess of 0·13% for combined liver function test abnormality), urinary composition alteration (556 [0·21% per annum] allocated statin <em>vs</em> 472 [0·18% per annum] allocated placebo, RR 1·18 [1·04–1·33]), and oedema (3495 [1·38% per annum] allocated statin <em>vs</em> 3299 [1·31% per annum] allocated placebo, RR 1·07 [1·02–1·12]). Analysis of the four trials of more intensive versus less intensive statin regimens also found significant excesses for abnormal liver transaminases and other liver function test abnormalities (supporting a dose-dependent effect), but no significant excess was found for urinary composition alteration or oedema.<h3>Interpretation</h3>Adverse event data from blinded randomised trials do not support causal relationships between statin therapy and most of the conditions (including cognitive impairment, depression, sleep disturbance, and peripheral neuropathy) listed in product labels as potential undesirable effects. In light of these findings, such labelling and other official sources of health information should be revised so that patients and their doctors can make appropriately informed decisions","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"42 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146129481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1016/s0140-6736(25)01948-8
Amy E Colson, Anthony M Mills, Moti N Ramgopal, Christopher Bettacchi, Olayemi O Osiyemi, Federico Hinestrosa, Gordon Crofoot, Harold P Katner, Hiroyuki Gatanaga, Margaret Johnson, Tracy L Diamond, Erika Barninger, Karen Eves, Feng-Hsiu Su, Yayun Xu, Stephanie O Klopfer, Luisa M Stamm, Michelle C Fox, Rima Lahoulou
{"title":"Switch to fixed-dose doravirine (100 mg) and islatravir (0·25 mg) once daily in virologically suppressed adults with HIV-1 on bictegravir, emtricitabine, and tenofovir alafenamide: 48-week results of a phase 3, multicentre, randomised, controlled, double-blind, non-inferiority trial","authors":"Amy E Colson, Anthony M Mills, Moti N Ramgopal, Christopher Bettacchi, Olayemi O Osiyemi, Federico Hinestrosa, Gordon Crofoot, Harold P Katner, Hiroyuki Gatanaga, Margaret Johnson, Tracy L Diamond, Erika Barninger, Karen Eves, Feng-Hsiu Su, Yayun Xu, Stephanie O Klopfer, Luisa M Stamm, Michelle C Fox, Rima Lahoulou","doi":"10.1016/s0140-6736(25)01948-8","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)01948-8","url":null,"abstract":"","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1016/s0140-6736(25)02013-6
Timo E Strandberg, Raul D Santos
{"title":"Product labels downplay the safety of statin therapy: evidence from randomised controlled trials","authors":"Timo E Strandberg, Raul D Santos","doi":"10.1016/s0140-6736(25)02013-6","DOIUrl":"https://doi.org/10.1016/s0140-6736(25)02013-6","url":null,"abstract":"","PeriodicalId":22898,"journal":{"name":"The Lancet","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：