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Prostate specific antigen kinetics: A review of prostate specific antigen doubling times and half-lives in patients with treated and untreated prostate cancer 前列腺特异性抗原动力学:前列腺特异性抗原在治疗和未治疗前列腺癌患者中的倍增时间和半衰期的综述
Pub Date : 2000-07-01 DOI: 10.1046/J.1525-1411.2000.23002.X
R. Pruthi
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引用次数: 3
Effect of Ageing on Morphologic and Clinical Predictors of Prostate Cancer Progression 衰老对前列腺癌进展的形态学和临床预测因子的影响
Pub Date : 2000-07-01 DOI: 10.1046/J.1525-1411.2000.23011.X
T. Stamey, M. Raimondo, C. Yemoto, J. McNeal, I. Johnstone
Objectives: Autopsy studies show that prostate cancer begins in the 4th and 5th decade of life. We sought to determine if increasing age at the time of diagnosis is related to morphologic and clinical predictors of cancer progression. Materials and Methods: We examined 7 morphologic variables known to impact progression of prostate cancer plus clinical stage and serum PSA in relation to increasing age. 981 untreated men undergoing radical prostatectomy were divided into 5 increasing age groups. Prostate size, which is known to increase with age, was used as a positive control. We compared the median and inter-quartile range for each grouping. Results: Increase in prostate weight was highly significant at all age differences. The % Gleason grade 4/5 cancer and cancer volume showed the most statistically significant changes with ageing, followed by non-organ confined cancer and capsular penetration both of which are highly correlated with cancer volume. Serum PSA was significant at 12, 17, and 22 years of age differences, but may be related more to prostate size than to increasing cancer volume. The presence of positive lymph nodes, seminal vesicle invasion, and palpable cancer were unrelated to increasing age. Conclusions: With the exception of increasing prostate size, % Gleason grade 4/5 cancer and cancer volume are the most significantly related variables to increasing age. Since % Gleason grade 4/5 cancer and cancer volume are also the primary determinants of failure to cure prostate cancer by radical prostatectomy, these age related changes suggest that detection of prostate cancer later in life will be accompanied by increased amounts of high grade cancer and larger tumor volumes. They also explain why, in so many younger men (age 45–60), the largest prostate cancer is often clinically insignificant (< 0.5 cc) at the time of radical prostatectomy.
目的:尸检研究表明前列腺癌开始于生命的第4和第5个十年。我们试图确定在诊断时年龄的增加是否与癌症进展的形态学和临床预测因子有关。材料和方法:我们研究了7种已知的影响前列腺癌进展的形态学变量,以及与年龄增长有关的临床分期和血清PSA。981例接受根治性前列腺切除术的未经治疗的男性分为5个年龄递增组。前列腺大小随着年龄的增长而增加,被用作阳性对照。我们比较了每组的中位数和四分位数范围。结果:前列腺重量的增加在各年龄段均有显著性差异。随着年龄的增长,% Gleason 4/5级癌和癌体积的变化最具统计学意义,其次是非器官限制性癌和包膜穿透性癌,两者与癌体积高度相关。血清PSA在12岁、17岁和22岁时差异显著,但可能更多地与前列腺大小有关,而不是与癌体积增加有关。淋巴结阳性、精囊浸润和可触及癌的存在与年龄增长无关。结论:除前列腺大小增加外,% Gleason 4/5级癌和癌体积是与年龄增长最显著相关的变量。由于% Gleason 4/5级癌症和肿瘤体积也是根治性前列腺切除术治疗前列腺癌失败的主要决定因素,这些年龄相关的变化表明,在生命后期发现前列腺癌将伴随着高级别癌症数量的增加和肿瘤体积的增大。他们还解释了为什么在这么多年轻男性(45-60岁)中,在根治性前列腺切除术时,最大的前列腺癌通常在临床上不显著(< 0.5 cc)。
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引用次数: 13
An Analysis of Patients with Clinically Localized High‐Risk Prostate Carcinoma 临床局限性高危前列腺癌患者分析
Pub Date : 2000-07-01 DOI: 10.1046/J.1525-1411.2000.23004.X
Q. Le, V. Weinberg, J. Ryu, P. Lewis, M. Roach
Objectives: The objectives of this study are the following: (1) to determine the outcome of patients with at least two unfavorable prognostic factors, as defined in the literature (tumor Stage ≤T2c, pretreatment PSA level >10 ng/ml, Gleason score ≥7); and (2) to define the impact of conformal radiotherapy (CRT), whole pelvic radiation, and hormonal therapy in the treatment of these patients. Materials and Methods: Between January 1, 1987, and December 31, 1995, 594 evaluable patients were treated with definitive radiotherapy for localized prostate carcinoma at the University of California, San Francisco and associated institutions. One hundred eighty-two patients had clinically localized high-risk prostate carcinomas defined as having at least two of the following adverse risk features: (1) tumor Stage ≥T2c; (2) pretreatment PSA level >10 ng/ml; and (3) Gleason score ≥7. One hundred sixty-four patients had >12 months of PSA follow-up and formed the cohort of this study. Fifty-eight percent of the patients had pretreatment PSA levels >20 ng/ml, 31% had Gleason scores of 8–10, and 60% had Stage T3 disease. Radiotherapy was delivered at 1.8 Gy/fraction/day, 5 days/week. The maximum tumor dose ranged from 60 to 82.4 Gy (median 73.7 Gy). Sixty-two percent of the group had elective whole-pelvic radiotherapy (WPRT), and 34% had androgen suppression therapy (AST). The median PSA follow-up was 39 months. PSA failure was defined by the consensus definition of the American Society for Therapeutic Radiotherapy and Oncology. Results: The 4-year estimate of biochemical freedom from relapse of the 164 patients with clinically localized high-risk prostate cancer was 39%. The median time to PSA failure was 18 months. The 4-year estimate of PSA control was 51% for patients with two adverse risk factors and 16% for those with three adverse risk factors. On univariate analysis, the number of adverse risk factors (p = 0.004) and WPRTs (p = 0.04) were significant prognostic factors for PSA control. The use of CRT (p = 0.08) and AST (p = 0.10) were of borderline significance. On multivariate analysis, the most significant independent prognostic factor for PSA control was the number of risk factors present (favoring two factors, p = 0.002). Treatment with WPRT (p = 0.03) was the next independent predictor. AST was of borderline significance (p = 0.10). Eight percent of patients (14 of 164) had Grade 1–2 cystitis and proctitis. There was no Grade 3–4 toxicity. Conclusions: The combination of pretreatment PSA level, Gleason score, and disease stage could reliably predict the prognosis of patients with localized high-risk prostate carcinoma treated with definitive radiotherapy. The use of prophylactic WPRT improved PSA control in patients with clinical Stage N0 disease who are at high-risk for nodal involvement. Patients with three adverse risk factors (PSA level >10 ng/ml, Gleason Score ≥7, and tumor Stage ≥2c) had a very poor prognosis when treated w
目的:本研究的目的如下:(1)确定至少有两种文献定义的不良预后因素(肿瘤分期≤T2c,预处理PSA水平>10 ng/ml, Gleason评分≥7)的患者的预后;(2)明确适形放疗(CRT)、全盆腔放疗和激素治疗对这些患者治疗的影响。材料和方法:1987年1月1日至1995年12月31日期间,594名可评估的患者在加州大学旧金山分校和相关机构接受了局限性前列腺癌的明确放疗。182例临床局限性高风险前列腺癌患者,定义为至少具有以下两种不良风险特征:(1)肿瘤分期≥T2c;(2)预处理PSA水平>10 ng/ml;(3)格里森评分≥7。164例患者PSA随访>12个月,形成本研究的队列。58%的患者预处理PSA水平>20 ng/ml, 31%的患者Gleason评分为8-10分,60%的患者为T3期疾病。放疗剂量1.8 Gy/次/天,5天/周。最大肿瘤剂量范围为60 ~ 82.4 Gy(中位73.7 Gy)。62%的患者接受选择性全盆腔放疗(WPRT), 34%的患者接受雄激素抑制治疗(AST)。中位PSA随访为39个月。PSA失败是由美国放射治疗和肿瘤学会的共识定义定义的。结果:164例临床局限性高危前列腺癌患者的4年生化无复发率为39%。到PSA失效的中位时间为18个月。有两种不良危险因素的患者的4年PSA控制估计为51%,有三种不良危险因素的患者为16%。在单因素分析中,不良危险因素数量(p = 0.004)和wprt (p = 0.04)是PSA控制的重要预后因素。CRT (p = 0.08)和AST (p = 0.10)的使用具有临界意义。在多变量分析中,PSA控制最重要的独立预后因素是存在的危险因素的数量(有利于两个因素,p = 0.002)。WPRT治疗(p = 0.03)是下一个独立预测因子。AST有显著性差异(p = 0.10)。8%的患者(164例中的14例)患有1-2级膀胱炎和直肠炎。无3-4级毒性。结论:结合PSA预处理水平、Gleason评分和疾病分期可以可靠地预测局部高危前列腺癌放疗患者的预后。预防性WPRT的使用改善了临床N0期疾病患者的PSA控制,这些患者有淋巴结累及的高风险。有三个不良危险因素(PSA水平>10 ng/ml, Gleason评分≥7,肿瘤分期≥2c)的患者在常规治疗时预后极差,应考虑采用新的有效的全身治疗。
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引用次数: 2
Preoperative Detection of Locally Advanced Prostate Cancer by Using Transrectal Ultrasound‐Guided Staging Prostate Biopsy 经直肠超声引导分期前列腺活检术前检测局部晚期前列腺癌
Pub Date : 2000-07-01 DOI: 10.1046/J.1525-1411.2000.23005.X
A. Zisman, M. Herbert, S. Strauss, H. Manor, Dan Liebovici, A. Lindner
Treatment for cure is reserved for patients with organ-confined prostate cancer. The clinical staging of prostate cancer lacks accuracy regarding local extension. The results of a transrectal ultrasound-guided staging biopsy (TGSB), performed in addition to routine sextant biopsies (RSBs) of the prostate, is defined as being positive when tumor cells are shown to invade extraprostatic loci and, thus, would certainly differentiate between organ-confined and locally advanced disease. Seventy-seven RSB + TGSB procedures were compared to 223 routine sextant prostate TRGBs. Prostate cancer (CaP) was detected in 24 patients (31%) and 60 patients (27%), respectively. In four RSB + TGSB procedures, local extension of CaP was depicted, and as a result radical prostatectomy was withheld. In six of seven patients undergoing radical prostatectomy (86%), the specimen analysis result was in agreement with the results of the preoperative TGSB. There were no extra complications associated with the performance of staging biopsies. We conclude that TGSB is safe and efficacious and that it should be performed in candidates for radical prostatectomy.
治疗是为器官局限性前列腺癌患者保留的。前列腺癌的临床分期缺乏局部延伸的准确性。在常规前列腺六分仪活检(RSBs)之外进行的经直肠超声引导分期活检(TGSB)的结果被定义为当肿瘤细胞侵入前列腺外位点时呈阳性,因此肯定可以区分器官局限性疾病和局部晚期疾病。将77例RSB + TGSB手术与223例常规六分仪前列腺trgb进行比较。前列腺癌(CaP)分别检出24例(31%)和60例(27%)。在4例RSB + TGSB手术中,CaP出现局部延伸,因此不进行根治性前列腺切除术。在接受根治性前列腺切除术的7例患者中,有6例(86%)标本分析结果与术前TGSB结果一致。没有与分期活检相关的额外并发症。我们的结论是,TGSB是安全有效的,应该在根治性前列腺切除术的候选人中进行。
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引用次数: 1
Therapy of Advanced Prostate Cancer: Part I: Antiandrogen Withdrawal, Androgen Receptor Mutations, and Secondary Hormonal Manipulations 晚期前列腺癌的治疗:第一部分:抗雄激素停药、雄激素受体突变和二次激素操纵
Pub Date : 2000-07-01 DOI: 10.1046/J.1525-1411.2000.23001.X
D. Reese, E. Small
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引用次数: 0
Dietary fat and prostate cancer: A review 膳食脂肪与前列腺癌:综述
Pub Date : 2000-07-01 DOI: 10.1046/J.1525-1411.2000.23010.X
S. Pandian, S. Heys, K. Wahle, S. McClinton
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引用次数: 0
PTEN: A Prostate Cancer Tumor‐Suppressor Gene PTEN:前列腺癌肿瘤抑制基因
Pub Date : 2000-04-01 DOI: 10.1046/J.1525-1411.2000.22001.X
Shivapriya Ramaswamy, W. Sellers
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引用次数: 4
African American Men with Prostate Cancer Treated by Simultaneous Irradiation 非裔美国男性前列腺癌同步放疗治疗
Pub Date : 2000-04-01 DOI: 10.1046/J.1525-1411.2000.22005.X
W. H. Williams, F. Critz, J. Benton, K. Levinson, W. Falconer, E. Harrison, C. Holladay, D. Holladay
Objectives: Reportedly, African American men (AAM) with prostate cancer present with more advanced disease and have worse outcomes than white men (WM). We evaluate this concept in our series of men with prostate cancer treated with modern simultaneous irradiation in a busy private practice. Materials and Methods: From 1993 to 1998, 1270 men with clinical stage T1T2N0 prostate cancer were treated by ultrasound-guided transperineal implantation of I-125 in the prostate and seminal vesicle (median dose 12,000 cGy) followed by external-beam radiation therapy (4500 cGy) including an additional 750 cGy seminal vesicle boost in men with adverse prognostic factors. None received neoadjuvant or adjuvant hormone therapy. The median pretreatment prostate specific antigen (PSA) level for 141 AAM and 1129 WM was 8.6 ng/ml and 7.1 ng/ml, respectively, a significant difference (p = 0.0001). Disease freedom is defined as achievement and maintenance of a PSA nadir of ≤ 0.2 ng/ml. The median follow-up is 24 months (range 12–66 months). Results: Disease-free survival for the entire group is 89% (± 3%) at 5 years. Overall, or when analyzed by stage, Gleason score, or age, AAM present with higher pretreatment PSA levels than WM. However, according to pretreatment PSA groups of ≤ 4.0 ng/ml, 4.1–10.0 ng/ml, 10.1–20.0 ng/ml, and > 20.0 ng/ml, the 5-year disease-free survival rates for AAM and WM in these groups are 100% and 95%, 85% and 92%, 67% and 80%, 76% and 83%, respectively. No significant difference in disease freedom is observed within the above PSA groups or by analysis of Gleason score or stage. With disease freedom as an end point, race is not a significant factor on multivariate analysis. Conclusions: AAM present with higher pretreatment PSA levels than WM both overall and when stratified by stage, Gleason score, or age. In this series, however, disease-free survival rates of AAM and WM are not significantly different overall or according to pretreatment variables. Thus, race does not appear to be an adverse prognostic factor after simultaneous irradiation.
目的:据报道,患有前列腺癌的非洲裔美国男性(AAM)比白人男性(WM)表现出更晚期的疾病和更差的预后。我们评估了这一概念在我们的一系列男性前列腺癌治疗与现代同步照射在繁忙的私人执业。材料和方法:从1993年到1998年,1270名临床分期为T1T2N0期前列腺癌的男性接受超声引导下经会阴前列腺和精囊I-125植入(中位剂量12,000 cGy),然后进行外束放射治疗(4500 cGy),包括对有不良预后因素的男性进行750 cGy的精囊增强治疗。没有人接受新辅助或辅助激素治疗。141例AAM和1129例WM的中位预处理前列腺特异性抗原(PSA)水平分别为8.6 ng/ml和7.1 ng/ml,差异有统计学意义(p = 0.0001)。无病定义为达到并维持≤0.2 ng/ml的PSA最低点。中位随访时间为24个月(12-66个月)。结果:全组5年无病生存率为89%(±3%)。总的来说,当按分期、格里森评分或年龄进行分析时,AAM呈现出比WM更高的预处理PSA水平。然而,根据≤4.0 ng/ml、4.1-10.0 ng/ml、10.1-20.0 ng/ml和> 20.0 ng/ml的预处理PSA组,AAM和WM的5年无病生存率分别为100%和95%、85%和92%、67%和80%、76%和83%。在上述PSA组内或通过格里森评分或分期分析,没有观察到疾病自由的显著差异。以无疾病为终点,种族在多变量分析中不是显著因素。结论:AAM的PSA水平总体上高于WM,无论按分期、Gleason评分或年龄分层。然而,在这个系列中,AAM和WM的无病生存率总体上或根据预处理变量没有显著差异。因此,种族似乎不是同时照射后的不良预后因素。
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引用次数: 2
The Anti‐Androgen Transfer 抗雄激素转移
Pub Date : 2000-04-01 DOI: 10.1046/J.1525-1411.2000.22006.X
Simon P. Kim, E. Moran, E. Bowes, Adam G. Tennant, C. Bennett
Objectives: Financial and nonfinancial barriers affect the care of prostate cancer patients. In this study, we evaluated whether financial considerations were a primary reason for lower income veterans with prostate cancer to transfer their care to Veterans Affairs (VA) Hospitals, and if so, which aspects of medical care were most affected by these considerations. Materials and Methods: Interviews with 106 veterans with prostate cancer were undertaken after the transfer of their care to the VA medical system. Respondents provided information about the primary reasons they shifted their care. Results: Although 64.2% of the patients had private health insurance before their initial visit to the VA, only 26.4% retained their private health insurance at the time of the interview, and 53.8 % transferred their entire medical care to the VA after the diagnosis of prostate cancer. Reasons for transferring care to the VA included the costs of oral anti-androgen therapy (34.9%), copayment costs for physician visits (30.2%), a feeling that medical care would be better in the VA system (26.4%), and copayment costs of luteinizing hormone-releasing hormone analogs (8.5%). Reasons for transfer varied with stage of disease at diagnosis (p < 0.05). The most common reasons for transfer were anti-androgen therapy costs among metastatic patients and, among patients with localized cancer, physician copayments and a feeling that care would be of higher quality in the VA system. Conclusions: Our findings suggest that there is a phenomenon, termed the “anti-androgen transfer,” that leads veterans with metastatic prostate cancer to transfer to the VA setting. The enactment of a comprehensive pharmaceutical benefit to the Medicare program will affect transfers of metastatic prostate cancer patients to the VA medical system.
目的:经济和非经济障碍影响前列腺癌患者的护理。在本研究中,我们评估了经济考虑是否是低收入前列腺癌退伍军人将其护理转移到退伍军人事务部(VA)医院的主要原因,如果是的话,医疗护理的哪些方面受这些考虑的影响最大。材料和方法:对106名前列腺癌退伍军人进行访谈,这些退伍军人的护理转移到VA医疗系统。受访者提供了关于他们转移护理的主要原因的信息。结果:尽管64.2%的患者在首次就诊前有私人医疗保险,但只有26.4%的患者在访谈时保留了私人医疗保险,53.8%的患者在诊断为前列腺癌后将其全部医疗服务转移到退伍军人事务部。将护理转移到退伍军人管理局的原因包括口服抗雄激素治疗的费用(34.9%),医生就诊的共同支付费用(30.2%),感觉退伍军人管理局系统的医疗服务会更好(26.4%),以及黄体生成素释放激素类似物的共同支付费用(8.5%)。转移的原因随诊断时疾病分期不同而不同(p < 0.05)。转移的最常见原因是转移性患者的抗雄激素治疗费用,以及局部癌症患者的医生共付费用,以及认为VA系统的护理质量更高。结论:我们的研究结果表明存在一种被称为“抗雄激素转移”的现象,这种现象导致患有转移性前列腺癌的退伍军人转移到退伍军人事务部。医疗保险计划的综合药品福利的制定将影响转移性前列腺癌患者向退伍军人医疗系统的转移。
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引用次数: 4
Pathologic Features of Occult Prostatic Carcinoma in Hypogonadal Men 性腺功能低下男性隐匿性前列腺癌的病理特征
Pub Date : 2000-04-01 DOI: 10.1046/J.1525-1411.2000.22004.X
Ping L. Zhang, G. Bubley, M. Upton, A. Morgentaler, W. DeWolf, S. Rosen
Objectives: Androgen therapy in hypogonadal men with low free testosterone levels (< 1.5 ng/dl) is potentially dangerous because exogenous androgen may stimulate occult prostatic adenocarcinoma (PA). Our previous study reported occult PA (14% incidence) in hypogonadal men with normal prostate specific antigen (PSA) levels and normal findings on digital rectal examination (DRE). The purpose of the current study was to examine the extent and nature of PA in prostatectomy specimens of hypogonadal patients. Materials and Methods: PA in these14 patients (the hypogonadal group) was compared to a control group of patients (n = 14). The two groups of patients were matched with similar mean ages, Gleason scores, and percentage of core involvement by PA. Subsequently, PA in prostatectomy specimens was analyzed in the two groups with additional comparison of immunohistochemical sections for androgen receptors, PSA, and prostatic acid phosphatase. Results: As expected, patients in the hypogonadal group had significantly lower levels of PSA and free testosterone than those in the control group (PSA 2.32 ± 0.60 ng/ml versus 8.06 ± 1.17 ng/ml, respectively; free testosterone 1.17 ± 0.09 ng/dl versus 1.74 ± 0.20 ng/dl, respectively). Prostatectomy specimens in hypogonadal patients (n = 9) showed a less extensive PA (0% positive margins, 11% perineural invasion, 78% unilateral tumor, and 22% bilateral tumor) compared to control prostatectomy specimens (n = 14) (21% positive margins, 42% perineural invasion, 21% unilateral tumor, and 58% bilateral tumor). However, immunohistochemical studies using anti-androgen receptor, anti-PSA and anti-prostatic acid phosphatase antibodies showed that carcinoma cells stained with equivalent intensity in both groups. Conclusions: PA in hypogonadal patients who had normal DREs and PSA levels appears to be less extensive but otherwise is not morphologically different than usual and should be treated in the same manner. The high incidence of occult PA in these hypogonadal patients makes screening prostate biopsies important before the androgen replacement therapy.
目的:对于游离睾酮水平低(< 1.5 ng/dl)的性腺功能低下男性,雄激素治疗具有潜在危险,因为外源性雄激素可能刺激隐匿性前列腺腺癌(PA)。我们之前的研究报告了在前列腺特异性抗原(PSA)水平正常且直肠指检(DRE)结果正常的性腺功能低下男性中隐匿性PA(14%)的发生率。本研究的目的是检查性腺功能低下患者前列腺切除术标本中PA的程度和性质。材料与方法:将这14例患者(性腺功能低下组)的PA与对照组(n = 14)进行比较。两组患者的平均年龄、Gleason评分和PA的核心受累百分比相似。随后,对两组前列腺切除术标本中的PA进行分析,并对雄激素受体、PSA和前列腺酸性磷酸酶的免疫组化切片进行比较。结果:正如预期的那样,性腺功能低下组患者的PSA和游离睾酮水平明显低于对照组(PSA分别为2.32±0.60 ng/ml和8.06±1.17 ng/ml;游离睾酮分别为1.17±0.09 ng/dl和1.74±0.20 ng/dl)。性腺功能低下患者的前列腺切除术标本(n = 9)显示,与对照前列腺切除术标本(n = 14)(21%的边缘阳性,42%的神经周围浸润,21%的单侧肿瘤,58%的双侧肿瘤)相比,PA的范围较小(0%阳性边缘,11%神经周围浸润,78%单侧肿瘤,22%双侧肿瘤)。然而,使用抗雄激素受体、抗psa和抗前列腺酸性磷酸酶抗体的免疫组化研究显示,两组的癌细胞染色强度相当。结论:在DREs和PSA水平正常的性腺功能减退患者中,PA似乎不那么广泛,但在形态学上与正常患者没有不同,应以同样的方式治疗。在这些性腺功能低下的患者中,隐匿性前列腺炎的发生率很高,因此在雄激素替代治疗前进行前列腺活检筛查非常重要。
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引用次数: 3
期刊
The open prostate cancer journal
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