Pub Date : 1999-03-01DOI: 10.1046/J.1525-1411.1999.09910.X
A. Gao
{"title":"The roles of homeobox genes in prostate cancer","authors":"A. Gao","doi":"10.1046/J.1525-1411.1999.09910.X","DOIUrl":"https://doi.org/10.1046/J.1525-1411.1999.09910.X","url":null,"abstract":"","PeriodicalId":22947,"journal":{"name":"The open prostate cancer journal","volume":"62 1","pages":"61-67"},"PeriodicalIF":0.0,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89598226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.1046/J.1525-1411.1999.00004.X
T. Buchholz, Y. Tony, Douglas Martin, C. R. Powell, P. Johnstone, P. Allen
Background: Hormonal therapy of prostate cancer is mediated, in part, through apoptosis. This process is dependent on intracellular calcium influx. This study investigates whether the use of calcium channel blockers inhibits this process and thereby negatively impacts hormonal therapy. Methods: Records from patients dying from metastatic prostate cancer in three medical centers were reviewed. The date of diagnosis, date of metastatic disease, date of death, Gleason sum, type of hormone therapy, and calcium channel blocker used were recorded. Results: Of the 180 patients, 26 were on a calcium channel blocker at the time of their hormonal therapy. The length of survival from the time of hormone therapy to death in these patients did not differ from the 154 patients not on a calcium channel blocker (respective median survival time of 819 days versus 730 days, p = 0.913—log rank test of the survival curves). Similarly, there were no differences in length of survival from the date of diagnosis between the two groups. Other analyzed factors (type of hormone therapy, Gleason score, and interval between diagnosis and metastatic disease) also did not affect length of survival from the time of hormonal treatment or time of diagnosis. Conclusion: We found no evidence that calcium channel blockers inhibit the therapeutic efficacy of hormonal treatment for metastatic prostate cancer.
{"title":"Do Calcium Channel Blockers Adversely Affect Hormonal Treatment of Prostate Cancer Through an Inhibition of Apoptosis","authors":"T. Buchholz, Y. Tony, Douglas Martin, C. R. Powell, P. Johnstone, P. Allen","doi":"10.1046/J.1525-1411.1999.00004.X","DOIUrl":"https://doi.org/10.1046/J.1525-1411.1999.00004.X","url":null,"abstract":"Background: Hormonal therapy of prostate cancer is mediated, in part, through apoptosis. This process is dependent on intracellular calcium influx. This study investigates whether the use of calcium channel blockers inhibits this process and thereby negatively impacts hormonal therapy. Methods: Records from patients dying from metastatic prostate cancer in three medical centers were reviewed. The date of diagnosis, date of metastatic disease, date of death, Gleason sum, type of hormone therapy, and calcium channel blocker used were recorded. Results: Of the 180 patients, 26 were on a calcium channel blocker at the time of their hormonal therapy. The length of survival from the time of hormone therapy to death in these patients did not differ from the 154 patients not on a calcium channel blocker (respective median survival time of 819 days versus 730 days, p = 0.913—log rank test of the survival curves). Similarly, there were no differences in length of survival from the date of diagnosis between the two groups. Other analyzed factors (type of hormone therapy, Gleason score, and interval between diagnosis and metastatic disease) also did not affect length of survival from the time of hormonal treatment or time of diagnosis. Conclusion: We found no evidence that calcium channel blockers inhibit the therapeutic efficacy of hormonal treatment for metastatic prostate cancer.","PeriodicalId":22947,"journal":{"name":"The open prostate cancer journal","volume":"279 1","pages":"43-48"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86736467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.1046/J.1525-1411.1999.00003.X
J. Forman
{"title":"Neutron Radiation for Prostate Cancer","authors":"J. Forman","doi":"10.1046/J.1525-1411.1999.00003.X","DOIUrl":"https://doi.org/10.1046/J.1525-1411.1999.00003.X","url":null,"abstract":"","PeriodicalId":22947,"journal":{"name":"The open prostate cancer journal","volume":"16 1","pages":"8-14"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86858290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1999-01-01DOI: 10.1046/J.1525-1411.1999.00002.X
L. Galejs, J. Hollander
Background: Prostate cancer has classically been discovered in 10% of prostatectomy specimens from presumed benign disease. Our objective was to review incidental cancer in transurethral prostatectomy (TURP) specimens and to establish whether or not the incidence, presentation, and pathology have changed since the advent of prostate specific antigen (PSA). Methods: Five hundred and thirty patients underwent TURP for presumed benign disease at our institution in 1985 (before PSA), and 481 underwent TURP between 1994 and 1995. The charts of all patients with cancer were reviewed. Patients with known cancer preoperatively were excluded. Charts were reviewed with regard to indication for TURP, presentation, age, size of prostate, digital rectal exam, PSA, and pathology report. The most recent preoperative PSA value was utilized. Pathologic factors included the weight (grams resected), grade, and extent of tumors. Stage T1a tumors were defined as having Gleason scores of <6 and volumes of <5%. If the percentage of volume was not given, the specimen was considered to be Stage T1a if cancer was present in three chips or less. All other tumors were considered Stage T1b disease. Results: In 1985, Stage T1a cancer comprised 4% of specimens, and Stage T1b comprised 6%. In 1994 and 1995, Stage T1a cancer comprised 4%, but Stage T1b comprised 3%. This change in the incidence of T1b disease was statistically significant with a p value of 0.04. There was no difference with regard to patient age, specimen weight, or Gleason score. Urinary retention was a more common indication for TURP in 1994 and 1995. Conclusions: Our findings suggest that PSA screening has decreased the incidence of Stage T1b prostate cancer.
{"title":"Incidental Carcinoma of the Prostate in the PSA Era","authors":"L. Galejs, J. Hollander","doi":"10.1046/J.1525-1411.1999.00002.X","DOIUrl":"https://doi.org/10.1046/J.1525-1411.1999.00002.X","url":null,"abstract":"Background: Prostate cancer has classically been discovered in 10% of prostatectomy specimens from presumed benign disease. Our objective was to review incidental cancer in transurethral prostatectomy (TURP) specimens and to establish whether or not the incidence, presentation, and pathology have changed since the advent of prostate specific antigen (PSA). Methods: Five hundred and thirty patients underwent TURP for presumed benign disease at our institution in 1985 (before PSA), and 481 underwent TURP between 1994 and 1995. The charts of all patients with cancer were reviewed. Patients with known cancer preoperatively were excluded. Charts were reviewed with regard to indication for TURP, presentation, age, size of prostate, digital rectal exam, PSA, and pathology report. The most recent preoperative PSA value was utilized. Pathologic factors included the weight (grams resected), grade, and extent of tumors. Stage T1a tumors were defined as having Gleason scores of <6 and volumes of <5%. If the percentage of volume was not given, the specimen was considered to be Stage T1a if cancer was present in three chips or less. All other tumors were considered Stage T1b disease. Results: In 1985, Stage T1a cancer comprised 4% of specimens, and Stage T1b comprised 6%. In 1994 and 1995, Stage T1a cancer comprised 4%, but Stage T1b comprised 3%. This change in the incidence of T1b disease was statistically significant with a p value of 0.04. There was no difference with regard to patient age, specimen weight, or Gleason score. Urinary retention was a more common indication for TURP in 1994 and 1995. Conclusions: Our findings suggest that PSA screening has decreased the incidence of Stage T1b prostate cancer.","PeriodicalId":22947,"journal":{"name":"The open prostate cancer journal","volume":"74 1","pages":"27-31"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75837351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1046/J.1525-1411.1999.00005.X
I. Kaplan, M. Jiroutek, D. Henry, C. Beard, A. D'Amico
Background: A significant proportion of patients will be found to have extracapsular disease and/or detectable prostate specific antigen (PSA) values after radical prostatectomy. The role of postoperative radiotherapy to the prostatic tumor bed remains controversial. Methods: Ninety patients were treated at the Joint Center for Radiation Therapy after radical prostatectomy. The medium dose to prostatic fossa was 64.0 Gy. Medium follow-up was 28.9 months (from time of prostatectomy). Failure after radiotherapy is defined as a persistently detectable PSA level or the development of a detectable PSA level after radiotherapy. None of the patients received androgen ablative therapy until documented postradiotherapy failure. Presurgical PSA levels, Gleason score, pathological findings at surgery, and preradiotherapy PSA levels were analyzed as predictors of PSA failure. Results: A presurgical PSA of >20.0 ng/ml is associated with PSA failure after radiotherapy (p = 0.0239). Preoperative Gleason score, PSA at time of radiotherapy or pathological findings at surgery do not predict for subsequent PSA failure. Conclusion: Postprostatectomy radiotherapy to the prostatic fossa is unlikely to provide long-term PSA-defined, disease-free survival for patients who undergo prostatectomy with a presurgical PSA of >20 ng/ml. Regardless of findings at surgery, these patients have a high rate of developing PSA failure.
{"title":"Postprostatectomy External Beam Irradiation","authors":"I. Kaplan, M. Jiroutek, D. Henry, C. Beard, A. D'Amico","doi":"10.1046/J.1525-1411.1999.00005.X","DOIUrl":"https://doi.org/10.1046/J.1525-1411.1999.00005.X","url":null,"abstract":"Background: A significant proportion of patients will be found to have extracapsular disease and/or detectable prostate specific antigen (PSA) values after radical prostatectomy. The role of postoperative radiotherapy to the prostatic tumor bed remains controversial. \u0000 \u0000 \u0000 \u0000Methods: Ninety patients were treated at the Joint Center for Radiation Therapy after radical prostatectomy. The medium dose to prostatic fossa was 64.0 Gy. Medium follow-up was 28.9 months (from time of prostatectomy). Failure after radiotherapy is defined as a persistently detectable PSA level or the development of a detectable PSA level after radiotherapy. None of the patients received androgen ablative therapy until documented postradiotherapy failure. Presurgical PSA levels, Gleason score, pathological findings at surgery, and preradiotherapy PSA levels were analyzed as predictors of PSA failure. \u0000 \u0000 \u0000 \u0000Results: A presurgical PSA of >20.0 ng/ml is associated with PSA failure after radiotherapy (p = 0.0239). Preoperative Gleason score, PSA at time of radiotherapy or pathological findings at surgery do not predict for subsequent PSA failure. \u0000 \u0000 \u0000 \u0000Conclusion: Postprostatectomy radiotherapy to the prostatic fossa is unlikely to provide long-term PSA-defined, disease-free survival for patients who undergo prostatectomy with a presurgical PSA of >20 ng/ml. Regardless of findings at surgery, these patients have a high rate of developing PSA failure.","PeriodicalId":22947,"journal":{"name":"The open prostate cancer journal","volume":"11 1","pages":"32-37"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88732238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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