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Relative risk, odds ratio and hazard ratio 相对风险、几率比例和危险比
Pub Date : 2024-07-11 DOI: 10.12746/swrccc.v12i52.1341
Shengping Yang, G. Berdine
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引用次数: 0
The sequential, multiple assignment, randomized trial (SMART) design 顺序、多重分配、随机试验(SMART)设计
Pub Date : 2024-01-29 DOI: 10.12746/swrccc.v12i50.1281
Shengping Yang, G. Berdine
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引用次数: 0
Rare solid pseudopapillary neoplasm in a Caucasian man 一名白种男子的罕见实性假乳头状瘤
Pub Date : 2024-01-29 DOI: 10.12746/swrccc.v12i50.1283
A. Ratra, B. Songtanin, Dauod Arif, Kanak Das
Pancreatic pseudopapillary neoplasms are rare pancreatic tumors and have a female predominance. Clinical manifestations include abdominal pain and/or an abdominal mass. Some patients are asymptomatic, and the tumors are found incidentally on imaging. Endoscopic ultrasound with fine needle biopsy with pathological tissue remains the gold standard for diagnosis. The malignant potential is low, and surgery remains the standard treatment. Keywords: Solid pseudopapillary neoplasm, pancreatic tumor, pancreatic malignancy, endoscopic ultrasound
胰腺假乳头状瘤是一种罕见的胰腺肿瘤,女性居多。临床表现包括腹痛和/或腹部肿块。部分患者无症状,肿瘤是在影像学检查中偶然发现的。内镜超声和细针活检及病理组织仍是诊断的金标准。恶性可能性较低,手术仍是标准治疗方法。关键词:实性假乳头状瘤实性假乳头状瘤、胰腺肿瘤、胰腺恶性肿瘤、内窥镜超声检查
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引用次数: 0
Fluid management based on renal function considerations 基于肾功能考虑的输液管理
Pub Date : 2024-01-29 DOI: 10.12746/swrccc.v12i50.1273
A. Motes, Kenneth Nugent, Camilo Pena
Intravenous fluid administration is one of the most commonly used interventions in acutely ill patients. Almost all hospitalized patients receive intravenous fluids for either volume resuscitation or as diluents for drug administration.  However, recent studies suggest that fluid overload is associated with acute kidney injury and that fluid administration beyond the volume needed to correct the fluid deficit is associated with increased morbidity, longer hospital stays, and mortality.  The exact cause and effect underlying this association remains uncertain.  Previous studies have reported a correlation between fluid overload and mortality in critically ill patients with acute respiratory distress syndrome, acute lung injury, sepsis, and acute kidney injury.  In patients with acute kidney injury, a higher percentage of fluid overload has been associated with higher mortality and shorter ventilator-free days starting during the initial management in the intensive care unit.  Similarly, in a large multicenter study, a positive fluid balance was an important factor associated with increased 60-day mortality in patients with acute kidney injury.  This review analyzes the use of intravenous fluids and renal function, including types of intravenous fluid, cumulative fluid targets, endpoint hemodynamic indicators, and renal replacement therapy for acute kidney injury.   Key words: volume status, intravenous fluids, fluid balance, acute kidney injury, volume excess
静脉输液是急性病患者最常用的干预措施之一。几乎所有住院患者都要接受静脉输液,以进行容量复苏或作为给药稀释剂。 然而,最近的研究表明,体液超负荷与急性肾损伤有关,而输液量超过纠正体液不足所需的量则会增加发病率、延长住院时间和死亡率。 这种关联的确切原因和影响仍不确定。 以往的研究报告显示,在患有急性呼吸窘迫综合征、急性肺损伤、败血症和急性肾损伤的重症患者中,液体超负荷与死亡率之间存在相关性。 在急性肾损伤患者中,液体超负荷比例越高,死亡率越高,在重症监护室初始治疗期间无呼吸机天数越短。 同样,在一项大型多中心研究中,体液正平衡是导致急性肾损伤患者 60 天死亡率升高的重要因素。 本综述分析了静脉输液的使用和肾功能,包括静脉输液的类型、累积输液目标、终点血流动力学指标以及急性肾损伤的肾脏替代疗法。 关键词: 容量状态、静脉输液、液体平衡、急性肾损伤、容量过多
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引用次数: 0
Robotic-assisted cholecystectomy in the third trimester of pregnancy 妊娠三个月的机器人辅助胆囊切除术
Pub Date : 2024-01-29 DOI: 10.12746/swrccc.v12i50.1221
Marvelyn Iweh, Seham Azzam, Jocelin Loewen, Christopher Wilhelm, Nathan Kragh, Basem Soliman
Acute and chronic cholecystitis commonly occur during pregnancy. Hormonal changes during pregnancy put women at a higher risk of forming gallstones and biliary dyskinesia leading to disease. The standard of care for acute cholecystitis is to have an elective cholecystectomy within 48 hours. Extensive research exists on the current practice of performing a laparoscopic cholecystectomy in pregnancy. Based on our review of the current literature, there is only one report that details a robotic cholecystectomy performed on a pregnant patient. This report will detail the methods used to perform the surgery and steps taken to ensure the safety of mother and fetus.  It will describe the unique circumstances surrounding the robotic technique used in this case and include the demographics and background of this patient, in an effort to promote this technique in future cases.   Key words: obstetrics, acute cholecystitis, symptomatic cholelithiasis, pregnancy, laparoscopic cholecystectomy, robotic-assisted cholecystectomy
急性和慢性胆囊炎通常发生在怀孕期间。妊娠期间荷尔蒙的变化使女性形成胆结石和胆汁运动障碍导致疾病的风险更高。治疗急性胆囊炎的标准是在 48 小时内进行选择性胆囊切除术。目前关于妊娠期腹腔镜胆囊切除术的研究非常广泛。根据我们对现有文献的查阅,只有一篇报告详细介绍了为妊娠期患者实施机器人胆囊切除术的情况。本报告将详细介绍手术方法以及为确保母亲和胎儿安全而采取的措施。 报告将描述该病例中使用机器人技术的独特情况,并包括该患者的人口统计学和背景,以便在今后的病例中推广这种技术。 关键词: 产科、急性胆囊炎、症状性胆石症、妊娠、腹腔镜胆囊切除术、机器人辅助胆囊切除术
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引用次数: 0
Pulmonary rehabilitation in patients with prior COVID-19 infections 曾感染 COVID-19 的患者的肺康复治疗
Pub Date : 2024-01-29 DOI: 10.12746/swrccc.v12i50.1271
Avantika Mallik, A. Motes, Drew Payne, Kenneth Nugent
Abstract Background: Patients with prior COVID-19 infections can develop persistent dyspnea and physical limitation.  This may reflect chronic lung disease, chronic heart disease, or neuromuscular disease.  Treatment approaches include pulmonary rehabilitation.  This study analyzed the benefits of conventional pulmonary rehabilitation in patients with chronic symptoms following COVID-19 infections. Methods: Twenty-eight patients completed pulmonary rehabilitation at University Medical Center in Lubbock, Texas.  The primary outcome was the time spent on four different types of exercise equipment during aerobic exercise sessions. Results: This study included 15 women and 13 men, with a mean age of 54.4 years.  The racial distribution included 12 White patients, 10 Hispanic patients, and 6 Black patients.  Ten patients had a smoking history, 19 patients used supplemental oxygen, 14 patients had hypertension, and 11 patients had diabetes.  The median COPD Assessment Test  (CAT) score was 21.5 (Q1, Q3: 17.5,29), the median Patient Health Questionnaire-9 (PHQ-9) score was 8 (Q1, Q3: 4.5,15.5), and the median Medical Research Council (MRC) score was 2.  Twenty-six patients had the abnormal chest x-rays within 3 months of starting the rehabilitation program; these included 5 patients with focal interstitial infiltrates, 9 patients with diffuse interstitial infiltrates, 6 patients with focal opacities, and 6 patients with bilateral opacities.  These patients completed 22.9 (Q1, Q3: 6.8,36) exercise sessions.  There were statistically significant increases in all machine times on all 4 machines. Conclusion: This study indicates pulmonary rehabilitation can significantly increase aerobic activity levels in patients with prior COVID-19 infections.  This improvement occurred in patients with important comorbidity, abnormal chest x-rays, and chronic oxygen supplementation requirements.  Patients with prior COVID-19 infections and persistent respiratory symptoms should be referred to pulmonary rehabilitation.   Key words: COVID-19, long COVID, rehabilitation
摘要 背景:曾感染 COVID-19 的患者会出现持续性呼吸困难和身体受限。 这可能反映出慢性肺部疾病、慢性心脏病或神经肌肉疾病。 治疗方法包括肺康复治疗。 本研究分析了常规肺康复治疗对 COVID-19 感染后出现慢性症状的患者的益处。研究方法28名患者在得克萨斯州卢伯克大学医学中心完成了肺康复治疗。 主要结果是有氧运动过程中在四种不同类型运动设备上花费的时间。研究结果这项研究包括 15 名女性和 13 名男性,平均年龄为 54.4 岁。 种族分布包括 12 名白人患者、10 名西班牙裔患者和 6 名黑人患者。 10 名患者有吸烟史,19 名患者使用辅助供氧,14 名患者患有高血压,11 名患者患有糖尿病。 慢性阻塞性肺病评估测试(CAT)中位数为 21.5 分(第一季度,第三季度:17.5,29 分),患者健康问卷-9(PHQ-9)中位数为 8 分(第一季度,第三季度:4.5,15.5 分),医学研究委员会(MRC)中位数为 2 分。 26 名患者在开始康复计划的 3 个月内胸部 X 光片出现异常,其中包括 5 名局灶性间质浸润患者、9 名弥漫性间质浸润患者、6 名局灶性不透明患者和 6 名双侧不透明患者。 这些患者共完成了 22.9 次(Q1, Q3: 6.8,36 次)锻炼。 从统计学角度看,所有 4 台机器的运动时间都有明显增加。结论:这项研究表明,肺康复治疗可显著提高曾感染 COVID-19 的患者的有氧运动水平。 这种改善发生在有重要合并症、胸部 X 光片异常和长期需要补充氧气的患者身上。 曾感染 COVID-19 并有持续呼吸道症状的患者应转诊接受肺康复治疗。 关键词:COVID-19COVID-19、长COVID、康复治疗
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引用次数: 0
The benefits of a closed ICU: a systematic review 封闭式重症监护室的益处:系统综述
Pub Date : 2024-01-29 DOI: 10.12746/swrccc.v12i50.1253
Or Belkin, Luis Fernandez-Nava, Muneeza Sheikh, Alan Pang, Bettina Schmitz, Chris Vogt, Robert Johnston, Cooper Phillips
This study compared closed and open intensive care unit (ICU) models in terms of patient outcomes. Closed ICUs had reduced mortality rates, shorter lengths of stay, and lower healthcare-associated infection rates. Intensivists in closed ICUs contributed to better outcomes due to their expertise and competence. Enhanced interdisciplinary collaboration, improved communication, and coordination in closed ICUs led to higher patient and family satisfaction.  In addition, closed ICUs were more cost-effective, with better resource use and reduced healthcare costs. Overall, closed ICU models have advantages in patient outcomes, better resource use, cost-effectiveness, and patient satisfaction compared to open ICU models.   Key words: Intensive care unit, ICU, patient outcomes, resource utilization, quality of care.
这项研究比较了封闭式和开放式重症监护病房(ICU)模式对患者的治疗效果。封闭式重症监护室的死亡率降低,住院时间缩短,医疗相关感染率降低。封闭式重症监护病房的重症监护医师凭借其专业知识和能力,为更好的治疗效果做出了贡献。封闭式重症监护病房加强了跨学科合作,改善了沟通和协调,从而提高了患者和家属的满意度。 此外,封闭式重症监护室的成本效益更高,资源利用率更高,医疗成本更低。总体而言,与开放式重症监护室模式相比,封闭式重症监护室模式在患者预后、资源利用、成本效益和患者满意度方面更具优势。 关键字重症监护室、ICU、患者预后、资源利用、护理质量。
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引用次数: 0
Leishmaniasis is now considered an endemic pathogen in Texas 利什曼病现在被认为是得克萨斯州的地方性病原体
Pub Date : 2024-01-29 DOI: 10.12746/swrccc.v12i50.1285
Barbara Mora, Jacob Nichols
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引用次数: 0
Mechanical power during mechanical ventilation 机械通气时的机械动力
Pub Date : 2024-01-29 DOI: 10.12746/swrccc.v12i50.1275
Kenneth Nugent, G. Berdine
Mechanical ventilation provides lifesaving support for patients with acute respiratory failure.  However, the pressures and volumes required to maintain gas exchange can cause ventilator-induced lung injury. The current approach to mechanical ventilation involves attention to both tidal volume and airway pressures, in particular plateau pressures and driving pressures. The ventilator provides energy to overcome airway resistance and to inflate alveolar structures. This energy delivered to the respiratory system per unit time equals mechanical power. Calculation of mechanical power provides a composite number that integrates pressures, volumes, and respiratory rates. Increased levels of mechanical power have been associated with tissue injury in animal models. In patients, mechanical power can predict outcomes, such as ICU mortality, when used in multivariable analyses. Increases in mechanical power during the initial phase of ventilation have been associated with worse outcomes. Mechanical power calculations can be used in patients on noninvasive ventilation, and measurements of mechanical power have been used to compare ventilator modes. Calculation of mechanical power requires measurement of the area in a hysteresis loop. Alternatively, simplified formulas have been developed to provide this calculation. However, this information is not available on most ventilators. Therefore, clinicians will need to make this calculation. In summary, calculation of mechanical power provides an estimate of the energy requirements for mechanical ventilation based on a composite of factors, including airway resistance, lung elastance, respiratory rate, and tidal volume.   Key words: mechanical ventilation, mechanical power, ventilator-induced lung injury, energy, work  
机械通气可为急性呼吸衰竭患者提供救命支持。 然而,维持气体交换所需的压力和容量可能会导致呼吸机诱发的肺损伤。目前的机械通气方法需要同时关注潮气量和气道压力,尤其是高原压力和驱动压力。呼吸机提供能量以克服气道阻力并使肺泡结构膨胀。单位时间内输送给呼吸系统的能量等于机械功率。机械功率的计算提供了一个综合数字,它综合了压力、容量和呼吸频率。在动物模型中,机械功率的增加与组织损伤有关。在病人身上,如果进行多变量分析,机械功率可以预测结果,如重症监护室死亡率。通气初始阶段机械功率的增加与较差的预后有关。机械通气功率计算可用于无创通气患者,机械通气功率测量可用于比较呼吸机模式。计算机械功率需要测量滞后环的面积。此外,还开发了简化公式来提供这种计算方法。但是,大多数呼吸机都无法提供这些信息。因此,临床医生需要进行计算。总之,机械功率的计算可根据气道阻力、肺弹性、呼吸频率和潮气量等综合因素估算出机械通气所需的能量。 关键词:机械通气、机械功率、呼吸机诱发肺损伤、能量、功
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引用次数: 0
Cefepime-induced non-convulsive status epilepticus 头孢吡肟诱发的非惊厥性癫痫状态
Pub Date : 2024-01-29 DOI: 10.12746/swrccc.v12i50.1277
Walter R Duarte-Celada, Samathorn Thakolwiboon, Jie Pan, Tulio Bueso, Jannatul Ferdous
Cefepime-induced non-convulsive status epilepticus (NCSE) can develop in patients with advanced age, renal impairment, and previous central nervous system disorders. Its clinical presentation varies from confusion, mutism, and decreased level of consciousness to coma. The typical electroencephalogram (EEG) findings are generalized spike and wave discharges of 1-3 Hz. We present a case series of 4 patients with cefepime-induced NCSE, including the clinical presentation and EEG findings. Electroencephalograms should be part of the workup of acute confusional state in patients on this antibiotic, and physicians should be aware of this uncommon complication.   Keywords: Non-convulsive status epilepticus, cefepime, confusion, mutism, electroencephalogram.
头孢吡肟诱发的非惊厥性癫痫状态(NCSE)可发生在高龄、肾功能受损和既往患有中枢神经系统疾病的患者身上。其临床表现从意识模糊、缄默、意识水平下降到昏迷不等。典型的脑电图(EEG)表现为1-3赫兹的全身性尖波和波状放电。我们介绍了 4 例头孢吡肟诱发的 NCSE 患者的病例系列,包括临床表现和脑电图检查结果。脑电图检查应成为使用这种抗生素的患者急性意识模糊状态检查的一部分,医生应注意这种不常见的并发症。 关键词非惊厥性癫痫状态 头孢吡肟 意识模糊 肢体缄默 脑电图
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引用次数: 0
期刊
The Southwest Respiratory and Critical Care Chronicles
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