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Assessing the performance of hospitals before and after the implementation of Iran’s Health Sector Evolution Plan (HSEP)using the Pabon Lasso model 使用Pabon Lasso模型评估实施伊朗卫生部门发展计划(HSEP)前后医院的绩效
Pub Date : 2021-01-10 DOI: 10.34171/MJIRI.35.23
R. Rahimisadegh, A. Haghdoost, S. Emadi, S. N. Hekmat
Background: The health sector evolution plan was implemented in 2014 in government hospitals across the country as a part of the universal health coverage achievement programs. This study assessed the performance of hospitals before and after the implementation of this plan, using the Pabon Lasso model. Methods: The population of this study consisted of the hospitals of the country in the 2013-2015 time frame; overall, 874 hospitals (94.5% of the population) were included in the study. In order to assess performance, we used the Pabon Lasso model and hospital performance indicators (Average Length of Stay, Bed Turnover, and Bed Occupancy Rate). The data were collected from the Hospital Information System and provincial deputies of curative affairs and were then analyzed using the descriptive indicators of mean, frequency, and median in SPSS 22. Also, Paired Student T-test and ANOVA were used to compare the performance of different groups of hospitals before and after the implementation of the health sector evolution plan. Results: The implementation of the health sector evolution plan has led to a significant improvement in the three performance indicators in the hospitals of the country. Before the implementation of the health sector evolution plan, the most inefficient, inefficient, fairly efficient, and most efficient zones included 31%, 18%, 17%, and 33% of the studied hospitals, respectively. However, the implementation of the health sector evolution plan changed the percentages to 29%, 21%, 20%, and 30%, respectively. Teaching hospitals, which are governmental and are mostly located in capital cities of the provinces, were overall more inefficient than nonteaching hospitals. Conclusion: The number of the most efficient and most inefficient hospitals has decreased, and the number of average performance hospitals has increased after the implementation of the health sector evolution plan. Therefore, the health sector evolution plan has not led to an overall increase or decrease in the performance of hospitals but has reduced the difference in the performance of hospitals. Equal support of government hospitals along with financial protection against health expenses, improves the performance indicators of hospitals and reduces performance differences among them.
背景:卫生部门发展计划于2014年在全国的政府医院实施,作为全民健康覆盖成就方案的一部分。本研究采用Pabon Lasso模型,评估了实施该计划前后医院的绩效。方法:研究对象为2013-2015年全国医院;总体而言,874家医院(占人口的94.5%)被纳入研究。为了评估绩效,我们使用了Pabon Lasso模型和医院绩效指标(平均住院时间、床位周转率和床位入住率)。数据收集自医院信息系统和省级医疗代表,然后使用SPSS 22中的平均值、频率和中位数描述性指标进行分析。采用配对学生t检验和方差分析比较不同组别医院实施卫生部门演进计划前后的绩效。结果:卫生部门发展计划的实施使该国医院的三项绩效指标有了显著改善。在实施卫生部门演变计划之前,最低效区、低效区、相当高效区和最高效区分别包括31%、18%、17%和33%的研究医院。然而,卫生部门发展计划的实施将这一比例分别改为29%、21%、20%和30%。公立教学医院大多位于省会城市,总体上比非教学医院效率更低。结论:实施卫生部门演进计划后,效率最高和效率最低的医院数量有所减少,平均绩效医院数量有所增加。因此,卫生部门演变计划并没有导致医院绩效的整体增加或减少,而是减少了医院绩效的差异。政府医院的平等支持以及对医疗费用的财政保护,改善了医院的绩效指标,缩小了医院之间的绩效差异。
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引用次数: 0
Barriers and facilitators of providing primary health care to Afghan refugees: A qualitative study from the perspective of health care providers. 向阿富汗难民提供初级保健的障碍和促进因素:从保健提供者的角度进行的定性研究。
Pub Date : 2021-01-01 DOI: 10.34171/MJIRI.35.1
N. Azizi, B. Delgoshaei, A. Aryankhesal
Background: One of the important aspects in the field of refugee health is the availability of primary health care, and the quality improvement of health care requires identifying barriers and facilitators. The present study aimed to identify obstacles and facilitators of providing primary health care to Afghan refugees from the perspective of health care providers. Methods: In this qualitative study, a semi-structured interview was conducted based on purposeful sampling with the involvement of 21 managers and experts in primary health care centers. Data were analyzed using the content analysis method and MaxQDA. Results: Data analysis led to the production of 4 main themes: (1) challenges while providing primary health care, with 10 subthemes; (2) challenges after providing care, with 4 subthemes; (3) opportunities, with 3 subthemes; and (4) solutions, with 6 subthemes. Conclusion: According to the results of this study, identifying the challenges and providing opportunities and solutions to existing problems seem to be effective steps in the quality improvement of providing primary health care to refugees.
背景:难民保健领域的一个重要方面是提供初级保健,而提高保健质量需要确定障碍和促进因素。本研究旨在从保健提供者的角度确定向阿富汗难民提供初级保健的障碍和促进因素。方法:本质性研究采用半结构化访谈法,以有目的的抽样为基础,对21位基层医疗保健中心的管理人员和专家进行访谈。采用内容分析法和MaxQDA对数据进行分析。结果:通过数据分析得出4个主题:(1)提供初级卫生保健的挑战,共10个分主题;(2)提供关怀后的挑战,共分4个主题;(3)机会,分3个主题;(4)解决方案,共6个子主题。结论:根据这项研究的结果,确定挑战、提供机会和解决现有问题似乎是提高向难民提供初级保健质量的有效步骤。
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引用次数: 0
Health literacy and quality of life among Iranian pregnant women: The mediating role of health locus of control. 伊朗孕妇的健康素养和生活质量:健康控制点的中介作用。
Pub Date : 2020-01-01 DOI: 10.34171/MJIRI.34.161
Marjan Mirzania, A. Khajavi, Akram Kharazmi, M. Moshki
Background: Main health challenge of the 21st century is improving quality of life (QoL). This study aimed to investigate the mediating role of health locus of control (HLC) between health literacy and QoL among Iranian pregnant women. Methods: In this cross sectional survey, 400 pregnant women referred to the community health centers of Gonabad, Iran, and completed the demographic, health literacy, QoL, and multidimensional HLC questionnaires during 2015-2016. Descriptive statistics and structural equation modeling were conducted using SPSS 22.0 version and AMOS 24.0 software. Results: The findings showed that health literacy has a significant positive effect on the physical (β= 0.54, p< 0.001) and mental (β= 0.57, p< 0.001) health. Also, it has a significant positive effect on internal subscale (β= 0.42, p< 0.001) and a significant negative effect on the chance (β= -0.51, p< 0.001) and powerful others (β= -0.33, p< 0.001) subscale of HLC. From HLC subscales, internal HLC had a significant positive effect on physical (β= 0.26, p< 0.001) and mental (β= 0.12, p= 0.010) health, while the effects of chance and powerful others on QoL dimensions were not significant. The findings indicated that internal HLC is a partial mediator between health literacy and physical dimension of QoL. Conclusion: The results indicate that health literacy can be considered as an effective factor in HLC orientations and can improve QoL. This reflects the need for more attention on health literacy and the recognition of the type of HLC beliefs, especially the internal belief in health promotion programs for pregnant women.
背景:21世纪的主要健康挑战是提高生活质量(QoL)。本研究旨在探讨健康控制源(HLC)在伊朗孕妇健康素养与生活质量之间的中介作用。方法:采用横断面调查方法,选取2015-2016年在伊朗戈纳巴德市社区卫生中心就诊的400名孕妇,填写人口统计、健康素养、生活质量和多维HLC问卷。采用SPSS 22.0版和AMOS 24.0软件进行描述性统计和结构方程建模。结果:健康素养对身体健康(β= 0.54, p< 0.001)和心理健康(β= 0.57, p< 0.001)均有显著的正向影响。对HLC的内部分量表(β= 0.42, p< 0.001)有显著的正向影响,对机会分量表(β= -0.51, p< 0.001)和强大他人分量表(β= -0.33, p< 0.001)有显著的负向影响。从HLC亚量表来看,内部HLC对身体健康(β= 0.26, p< 0.001)和心理健康(β= 0.12, p= 0.010)有显著的正向影响,而机会和强大的他人对生活质量的影响不显著。研究结果显示,健康素养与身体维度之间存在部分中介关系。结论:健康素养是影响健康取向的有效因素,可提高生活质量。这反映了需要更多地关注健康素养和对HLC信念类型的认识,特别是对孕妇健康促进计划的内在信念。
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引用次数: 0
The satisfaction with life scale: Psychometric properties in Pakistani population. 生活满意度量表:巴基斯坦人口的心理测量特征。
Pub Date : 2020-01-01 DOI: 10.34171/MJIRI.34.159
Nadia Barki, F. R. Choudhry, Khadeeja Munawar
Background: The construct of satisfaction with life has been studied across various cultures through the Satisfaction with Life Scale. The Satisfaction with Life Scale (SWLS) has been validated across several populations and languages. There are no published psychometric properties of its Urdu version. Hence, the aim of this study was to ascertain the psychometric properties of the Urdu version of the SWLS among the Urdu speaking population of Pakistan. Methods: The SWLS has already been translated into Urdu, and the Urdu version is available on the author's website however there is no information about its psychometric properties. To establish the psychometric properties especially the factor structure of the already translated Urdu SWLS, the SWLS-Urdu was administered to Urdu speaking population residing in Pakistan. The statistical analyses (i.e., normality through skewness and kurtosis, Kaiser-Meyer-Olkin (KMO) and Bartlett's test of sphericity, and test and re-test reliability) were conducted through SPSS version 25.0. Structure Equation Modelling via maximum likelihood method of estimation was used to perform confirmatory factor analysis on the data using AMOS 20.0. The significance level was set at p < 0.05. Results: The study was completed by recruiting 120 participants from different universities in Lahore, Pakistan. The sample was equally divided between male and female participants. The mean age of participants was 22.7(3.6) years. Test of the adequacy of the sample through Kaiser-Mayer-Olkin showed KMO=0.88 and Bartlett's test of sphericity (p<0.001). The Cronbach's alpha reliability of the scale was 0.90 and Confirmatory Factor Analysis confirmed a one-factor model as a good fit with strong statistical evidence. No factorial group variances were noticed in male and female participants. Conclusion: This study shows that Urdu SWLS has sound psychometric properties, is linguistically and culturally acceptable, and equally useful in assessing satisfaction with life in the Urdu speaking population.
背景:通过生活满意度量表研究了不同文化对生活满意度的建构。生活满意度量表(SWLS)已在多个人群和语言中得到验证。它的乌尔都语版本没有公开的心理测量特性。因此,本研究的目的是确定巴基斯坦乌尔都语人口中乌尔都语版本的SWLS的心理测量特性。方法:SWLS已经被翻译成乌尔都语,在作者的网站上可以找到乌尔都语版本,但没有关于其心理测量特性的信息。为了确定已翻译的乌尔都语SWLS的心理测量特性,特别是因子结构,对居住在巴基斯坦的乌尔都语人口进行了SWLS-Urdu测试。统计分析(即通过偏度和峰度进行正态分析,Kaiser-Meyer-Olkin (KMO)和Bartlett's球度检验,以及检验和重测信度)通过SPSS 25.0版本进行。采用最大似然估计法的结构方程建模,采用AMOS 20.0软件对数据进行验证性因子分析。显著性水平为p < 0.05。结果:本研究招募了120名来自巴基斯坦拉合尔不同大学的参与者。样本在男性和女性参与者之间平均分配。参与者的平均年龄为22.7(3.6)岁。通过Kaiser-Mayer-Olkin检验样本的充分性,KMO=0.88, Bartlett球度检验(p<0.001)。量表的Cronbach's alpha信度为0.90,验证性因子分析证实单因素模型拟合良好,具有较强的统计证据。在男性和女性参与者中没有发现因子组差异。结论:本研究表明乌尔都语SWLS具有良好的心理测量特性,在语言和文化上是可接受的,并且在评估乌尔都语人群的生活满意度方面同样有用。
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引用次数: 0
Effect of maternal mental health during pregnancy on infant growth at six months of age in Suburban communities in South of Iran. 伊朗南部郊区社区孕妇孕期心理健康对6个月婴儿生长的影响。
Pub Date : 2020-01-01 DOI: 10.34171/MJIRI.34.157
H. A. Gharaei, S. Nematollahi, Hossein Moameri, A. Madani, M. Parsaeian, K. Holakouie-Naieni
Background: Due to the controversial effects of mental health disorders during pregnancy on infant health, the present study aimed to evaluate the effect of gestational depression, stress, and anxiety on the growth of offspring at six months of age in disadvantaged communities in South of Iran. Methods: The sample comprised of 470 pregnant women (response rate=98%) who are participated in the Bandar Abbas Pregnancy Cohort study. Maternal mental health was measured by the DASS-21 questionnaire during pregnancy. Data on infant growth was collected based on infant`s growth chart at six months of age. The relative risk of suboptimal infant growth was calculated by Modified Poisson regression models at 5% significant level. Results: The prevalence of depression, anxiety, and stress was 19.0%, 26.1% and 6.5%, respectively. At six months of age, the mean (SD) of infant`s weight (gram), height (cm) and head circumference (cm) were 7287.30 (1019.85), 63.23 (5.62) and 41.39 (2.70), respectively. Compared to normal mothers, the risk of suboptimal weight at six months of age significantly increased by 71% in mothers who were classified as having depression (Adjusted RR: 1.71, 95% CI: 1.07, 2.09). The presence of anxiety significantly increased the risk of suboptimal height at six months of age by 43% (ARR: 1.43, 95% CI: 1.07, 1.92). There were no statistically significant effects of either depression anxiety or stress on the suboptimal head circumference at six months of age. Conclusion: Our results showed that mental health disorders of pregnant women might adversely influence the weight and height growth of offspring within the first six months of age. Screening protocols to early diagnose of mental health disorders during pregnancy, and to strict follow up of diagnosed cases postpartum are proposed.
背景:由于怀孕期间精神健康障碍对婴儿健康的影响存在争议,本研究旨在评估妊娠期抑郁、压力和焦虑对伊朗南部弱势社区6个月大的后代生长的影响。方法:样本包括参加阿巴斯港妊娠队列研究的470名孕妇(有效率为98%)。采用DASS-21问卷测量妊娠期产妇心理健康状况。婴儿生长数据是根据婴儿6个月时的生长图表收集的。采用修正泊松回归模型在5%显著水平下计算婴儿生长次优的相对风险。结果:抑郁、焦虑和压力的患病率分别为19.0%、26.1%和6.5%。6月龄时,婴儿体重(g)、身高(cm)和头围(cm)均值(SD)分别为7287.30(1019.85)、63.23(5.62)和头围(41.39)。与正常母亲相比,被归类为抑郁症的母亲在6个月大时体重不达标的风险显著增加了71%(调整后RR: 1.71, 95% CI: 1.07, 2.09)。焦虑的存在使6个月大儿童出现亚理想身高的风险显著增加43% (ARR: 1.43, 95% CI: 1.07, 1.92)。在6个月大时,抑郁、焦虑或压力对次优头围没有统计学上的显著影响。结论:孕妇的心理健康障碍可能会对子代6个月内的体重和身高生长产生不利影响。提出了筛查方案,以早期诊断怀孕期间的心理健康障碍,并严格随访产后诊断病例。
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引用次数: 0
Prevalence of cigarette smoking among college students in Iran: An updated systematic review and meta-analysis of observational studies. 伊朗大学生吸烟率:观察性研究的最新系统回顾和荟萃分析
Pub Date : 2020-01-01 DOI: 10.34171/MJIRI.34.165
M. Khodadost, Khadije Maajani, A. Noroozi, S. Motevalian, M. Naserbakht, F. Sarvi, Roohollah Seddigh, L. Jamshidi, S. Yavari, Malihe Khoramdad, Ebrahim Ghodusi, A. Hajebi
Background: Cigarette smoking is known as a gateway drug for illicit drug use in youth. The objective of this study is to assess the prevalence of cigarette smoking in the college students in Iran. Methods: We searched electronic databases including Scopus, Medline/PubMed, Google Scholar and Web of Science, and national databases such as Magiran, Scientific Information Database, Iranmedex, Medlib, Irandoc, and IranPsych from 1946 to 21st July 2018 without any language restriction using a proper search strategy. We used a random effect model to calculate the pooled prevalence of cigarette smoking in college students in Iran. Chi-square test and I2 index were used to evaluate the heterogeneity between the studies. We used the meta-regression and subgroup analysis to assess the potential source of heterogeneity. Stata software, version 11 (StataCorp, TX) was used for all statistical analysis. Results: We included 60 eligible articles in our study. The pooled prevalence of cigarette smoking at least once in the lifetime was 19% (95%CI: 17-22). The I2 index indicated considerable between-study heterogeneity (I2 =98%, p<0.001). The pooled prevalence of cigarette smoking at least once in the lifetime in males and females was 28% (95% CI: 23-34) and 9% (95% CI: 6-13), respectively. In multivariable meta-regression, a significant association was shown between the year of study (β=-13.1, p=0.011) and sampling method (β=-12.8 p=0.017) and daily use in the last month. Conclusions: Increasing prevalence of smoking among Iranian university students is an important health priority. Increasing preventive and health education programs are recommended.
背景:吸烟被认为是青少年非法使用毒品的入口毒品。本研究的目的是评估伊朗大学生吸烟的流行程度。方法:检索1946年至2018年7月21日期间的Scopus、Medline/PubMed、Google Scholar和Web of Science等电子数据库,以及Magiran、Scientific Information Database、Iranmedex、Medlib、Irandoc和IranPsych等国家数据库,不受任何语言限制。我们使用随机效应模型来计算伊朗大学生吸烟的总流行率。采用卡方检验和I2指数评价研究间的异质性。我们使用元回归和亚组分析来评估异质性的潜在来源。所有统计分析均使用Stata软件,版本11 (StataCorp, TX)。结果:我们纳入了60篇符合条件的文章。一生中至少吸烟一次的总流行率为19% (95%CI: 17-22)。I2指数显示研究间存在显著异质性(I2 =98%, p<0.001)。男性和女性一生中至少吸烟一次的总患病率分别为28% (95% CI: 23-34)和9% (95% CI: 6-13)。在多变量元回归中,研究年份(β=-13.1, p=0.011)和抽样方法(β=-12.8 p=0.017)与最近一个月的每日使用量之间存在显著关联。结论:伊朗大学生吸烟率的上升是一个重要的健康优先事项。建议增加预防和健康教育项目。
{"title":"Prevalence of cigarette smoking among college students in Iran: An updated systematic review and meta-analysis of observational studies.","authors":"M. Khodadost, Khadije Maajani, A. Noroozi, S. Motevalian, M. Naserbakht, F. Sarvi, Roohollah Seddigh, L. Jamshidi, S. Yavari, Malihe Khoramdad, Ebrahim Ghodusi, A. Hajebi","doi":"10.34171/MJIRI.34.165","DOIUrl":"https://doi.org/10.34171/MJIRI.34.165","url":null,"abstract":"Background: Cigarette smoking is known as a gateway drug for illicit drug use in youth. The objective of this study is to assess the prevalence of cigarette smoking in the college students in Iran. Methods: We searched electronic databases including Scopus, Medline/PubMed, Google Scholar and Web of Science, and national databases such as Magiran, Scientific Information Database, Iranmedex, Medlib, Irandoc, and IranPsych from 1946 to 21st July 2018 without any language restriction using a proper search strategy. We used a random effect model to calculate the pooled prevalence of cigarette smoking in college students in Iran. Chi-square test and I2 index were used to evaluate the heterogeneity between the studies. We used the meta-regression and subgroup analysis to assess the potential source of heterogeneity. Stata software, version 11 (StataCorp, TX) was used for all statistical analysis. Results: We included 60 eligible articles in our study. The pooled prevalence of cigarette smoking at least once in the lifetime was 19% (95%CI: 17-22). The I2 index indicated considerable between-study heterogeneity (I2 =98%, p<0.001). The pooled prevalence of cigarette smoking at least once in the lifetime in males and females was 28% (95% CI: 23-34) and 9% (95% CI: 6-13), respectively. In multivariable meta-regression, a significant association was shown between the year of study (β=-13.1, p=0.011) and sampling method (β=-12.8 p=0.017) and daily use in the last month. Conclusions: Increasing prevalence of smoking among Iranian university students is an important health priority. Increasing preventive and health education programs are recommended.","PeriodicalId":22988,"journal":{"name":"The Medical Journal of The Islamic Republic of Iran","volume":"24 1","pages":"165-165"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76224960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arthroscopic repair of complete tear of rotator cuff 关节镜下完全性肩袖撕裂修复术
Pub Date : 2009-08-10 DOI: 10.29011/2575-9760.000188
Hamidreza Aslani, H. Vahedi, Z. Zafarani
Background: Rotator cuff tear is one of the most common causes of shoulder complaints in the elderly. Based on the severity and patient's condition, a variety of methods applies to manage the tear and surgery is an important method, which could be done by open or arthroscopic technique. The current study aimed to investigate and report short-term results of arthroscopic repair of complete rotator cuff tears. Methods: This was a cross-sectional study on 183 patients who underwent arthroscopic surgery to repair rotator cuff tear in three different hospitals of Tehran between January 2003 and August 2006. Of all patients, 107 cases included in our study, which had a complete rotator cuff tear, and at least one-year follow up record. 89 patients (56 male and 33 female) attended assessment sessions and were evaluated by UCLA (University of California, Los Angeles) Shoulder and Elbow Scoring System, pre- and post-operatively, and acromioplasty was performed in 83 patients. Results: With a mean age of 53.2 ± 15.8 (32-71) years, the average UCLA score was 11.3 before the surgery and 31.4 post-operatively. There were 11 patients with excellent scores, 62 good, 11 fair, and 5 poor scores. 9 out of 11 cases with excellent score and 34 out of 62 with good score were younger than 55 years; however, 13 cases were older than 60 years amongst 16 fair or poor scores. Conclusions: Arthroscopic repair of complete rotator cuff tear would cause a significant improvement in a short-term period and results are better in younger patients, through the UCLA scoring system.
背景:肩袖撕裂是老年人肩部疾病最常见的原因之一。根据撕裂的严重程度和患者的病情,有多种治疗方法,手术是治疗撕裂的重要方法,手术可以通过开放或关节镜技术进行。目前的研究旨在调查和报告关节镜修复完全性肩袖撕裂的短期结果。方法:本研究对2003年1月至2006年8月在德黑兰三家不同医院接受关节镜手术修复肩袖撕裂的183例患者进行了横断面研究。在我们研究的所有患者中,有107例完全性肩袖撕裂,并有至少一年的随访记录。89名患者(56名男性和33名女性)参加了评估会议,并由UCLA(加州大学洛杉矶分校)肩关节评分系统进行了术前和术后评估,其中83名患者进行了肩峰成形术。结果:患者平均年龄53.2±15.8(32-71)岁,术前平均UCLA评分11.3,术后平均UCLA评分31.4。优11例,良62例,一般11例,差5例。11例优秀者中有9例,62例优秀者中有34例年龄小于55岁;16例中,年龄大于60岁的有13例。结论:通过UCLA评分系统,关节镜下修复完全性肩袖撕裂可在短期内显著改善,年轻患者效果更好。
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引用次数: 0
LATERAL INTERNAL SPHINCTEROTOMY UNDER LOCAL ANESTHESIA: A RANDOMIZED CLINICAL TRIAL 局部麻醉下外侧内括约肌切开术:一项随机临床试验
Pub Date : 2006-05-15 DOI: 10.1007/S10353-006-0271-7
S. Kashani, M. Lak, H. Mohebi, Farzad Panahe
{"title":"LATERAL INTERNAL SPHINCTEROTOMY UNDER LOCAL ANESTHESIA: A RANDOMIZED CLINICAL TRIAL","authors":"S. Kashani, M. Lak, H. Mohebi, Farzad Panahe","doi":"10.1007/S10353-006-0271-7","DOIUrl":"https://doi.org/10.1007/S10353-006-0271-7","url":null,"abstract":"","PeriodicalId":22988,"journal":{"name":"The Medical Journal of The Islamic Republic of Iran","volume":"18 1","pages":"37-40"},"PeriodicalIF":0.0,"publicationDate":"2006-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80489612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
USEFULNESS OF SLEEP-DEPRIVED EEG IN THE DIAGNOSIS OF SEIZURE DISORDERS IN CIDLDREN 睡眠剥夺脑电图在儿童癫痫症诊断中的价值
Pub Date : 2004-05-15 DOI: 10.1055/S-2006-945869
S. Rafiei
The provocative effects of sleep deprivation (SD) on patients withseizure disorder and on the electroencephalogram (EEG) are wellknown.The purpose of the study was to test its routine use andusefulness in the pediatric and adolescent age group with, or suspectof having, seizure disorder, especially those presenting with firstunprovoked seizure. Between September 2000 and November 2002, amongpatients referring to the author's clinic and the Pediatric EmergencyDepartment of Nemazi Hospital, Shiraz, 598 children and adolescentswere randomly assigned to a 10-minute surface EEG, either routinely, orafter a period of partial or total SD. Those who refused or could nottolerate the SD procedure entered the routine group. The EEG's wereanalyzed for the presence of epileptic abnormality. Of 598 patients,544( 91%) had clinical seizures; the rest (54, 9%) were seizuresuspects or had seizure "mimickers" (syncope, night terrors,pseudo-seizures, etc). Of seizure patients, 210 ( 38.6 % ) sufferedfrom a first unprovoked seizure, and the rest (334, 61.4%) had morethan one seizure episode at the time of EEG performance. Abnormalepileptiform EEG's were more frequently seen in the group of seizurepatients who were sleep-deprived before performing the EEG, as comparedto the routine group. Conversely, more normal EEG's were seen uponroutine performance of EEG ( p value <00001, χ2 = 76.5). Similarly, more abnormal sleep-deprived EEG's were seen in patientswith first unprovoked seizure than when EEG was done routinely in thissubgroup of patients. Patients with complex partial seizure hadsignificantly more abnormal EEG's when subjected to SD (p<00001). Older patients could tolerate SD better than the younger age group; somore routine EEG's had to be performed in the younger age group.Youngerchildren could only tolerate partial SD. There was no difference in theyield of EEG in patients with absence epilepsy between the two groups.In 5 patients with juvenile myoclonic epilepsy, SD precipitated ageneralized tonic-clonic seizure which necessitated acuteanti-epileptic drug administration to the seizure activity. Allpatients with non-seizure episodes showed normal EEG's. In conclusionSD can be safely applied in the work-up of selected pediatric patientswith seizure disorder, especially in those with their first unprovokedseizure, in whom an abnormal EEG might dictate anti-epileptic drugtherapy. Not all children with seizure disorder need to undergo SD forEEG, as it may not be necessary in some, and intolerable in others. Innon-seizure episodes, if used in appropriate pediatric age groups, itcan be very helpful to ensure that a seizure disorder is not present.
睡眠剥夺(SD)对癫痫患者和脑电图(EEG)的刺激作用是众所周知的。该研究的目的是测试其在患有或怀疑患有癫痫发作障碍的儿童和青少年年龄组中的常规使用和有用性,特别是那些首发发作的患者。2000年9月至2002年11月,在提交人的诊所和设拉子Nemazi医院儿科急诊科就诊的患者中,598名儿童和青少年被随机分配进行10分钟的表面脑电图,要么是常规的,要么是部分或全部SD后。那些拒绝或不能忍受SD程序的人进入常规组。分析脑电图是否存在癫痫异常。598例患者中,544例(91%)出现临床癫痫发作;其余(54.9%)为癫痫发作或有癫痫“模仿症状”(晕厥、夜惊、伪癫痫发作等)。在癫痫患者中,210例(38.6%)发生首次无因性癫痫发作,其余334例(61.4%)在脑电图表现时发作不止一次。与常规组相比,在进行脑电图检查前被剥夺睡眠的癫痫患者组更常出现异常的癫痫样脑电图。相反,正常脑电图高于常规脑电图(p值<00001,χ2 = 76.5)。同样,与常规脑电图相比,首次非诱发性癫痫发作的患者出现更多异常的睡眠剥夺脑电图。伴有复杂部分性癫痫发作的患者在SD时异常脑电图显著增加(p<00001)。老年患者对SD的耐受性优于年轻患者;必须对更小的年龄组进行常规脑电图检查。年幼的儿童只能忍受部分SD。两组间无明显差异。在5例青少年肌阵挛性癫痫患者中,SD诱发全身性强直-阵挛性发作,需要对发作活动给予急性抗癫痫药物。所有非癫痫发作患者脑电图正常。综上所述,sd可以安全地应用于有癫痫障碍的儿童患者的检查中,特别是那些首次非诱发性癫痫发作的患者,在这些患者中,脑电图异常可能指示抗癫痫药物治疗。并非所有患有癫痫的儿童都需要接受SD forEEG,因为某些儿童可能没有必要,而另一些儿童则无法忍受。在非癫痫发作时,如果在适当的儿童年龄组使用,它可以非常有助于确保癫痫发作障碍不存在。
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引用次数: 0
MORPHINE RELEASES GLUTAMATE THROUGH AMPA RECEPTORS IN THE VENTRAL TEGMENTAL AREA: A MICRODIALYSIS STUDY IN CONSCIOUS RATS 吗啡通过腹侧被盖区ampa受体释放谷氨酸:有意识大鼠的微透析研究
Pub Date : 2003-11-10 DOI: 10.22037/IJPR.2010.109
H. Alaei, M. Huotari, P. Piepponen, L. Ahtee, O. Hänninen, P. Männistö
Drug addiction has developed to a social illness. Changes in glutamate transmission have been recorded by the repeated administration of addictive drugs into VTA. In this investigation, In vivo microdialysis was used to study the effects of morphine on glutamate release from the ventral tegmentum area (VTA) in freely moving rats. Rats were anesthetized with chloral hydrate (350 mg/kg, i.p.) and placed in a Kopf stereotaxic apparatus. A vertical guide cannula was implanted through a burr hole and secured with dental cement held on the skull with small screws. The final co-ordinates for the tip of the microdialysis probe in right VTA relative to bregma were: anteroposterior (AP), 5.8; lateral (L), 0.5 and dorsoventral (DV), 9.0 according to atlas of Paxinos. One week after surgery, the microdialysis probe was inserted into the guide cannula and perfused with artificial cerebrospinal fluid (aCSF). After a 60 min wash out period, dialysate samples were collected in 20 min periods in vials and 20?m was used for glutamate HPLC analysis. Intraperitoneal (IP) injection of acute and repeated administration of morphine at increasing doses enhanced significantly glutamate release. Only a minor tolerance developed to this effect of morphine. AP-5 (2-amino-5-phosphonovaleric acid, 0.5 mg/kg i.p.), a NMDA receptor antagonist, given 20 min before each repeated morphine injection, did not have a significant effect on the stimulated glutamate release. Conversely, injection of CNQX (6-cyano-7-nitroquinnoxaline-2, 3-dione, 0.5 mg/kg i.p), an AMPA receptor antagonist, 20 min before each morphine dose was found to markedly inhibit morphine-induced glutamate release in the VTA. In all experiments, release of glutamate reduced by time. These results show for the first time that acute and repeated injection of morphine stimulates glutamate release in the conscious rat VTA via AMPA receptors.
吸毒成瘾已发展成为一种社会疾病。通过在VTA中反复施用成瘾性药物,记录了谷氨酸传递的变化。本研究采用体内微透析法研究吗啡对自由活动大鼠腹侧被盖区谷氨酸释放的影响。用水合氯醛(350 mg/kg, i.p.)麻醉大鼠,置于Kopf立体定向器中。垂直引导套管通过一个毛刺孔植入,用牙水泥固定在颅骨上,并用小螺钉固定。右VTA微透析探头尖端相对于bregma的最终坐标为:正位(AP), 5.8;根据Paxinos图谱,侧位(L)为0.5,背腹位(DV)为9.0。术后1周将微透析探头插入引导管内,灌注人工脑脊液(aCSF)。冲洗60分钟后,透析液样品在20分钟内收集在小瓶和20?m用于谷氨酸高效液相色谱分析。急性腹腔注射和不断增加剂量的吗啡可显著增强谷氨酸释放。对吗啡的这种作用只有轻微的耐受性。每次重复注射吗啡前20分钟给予NMDA受体拮抗剂AP-5(2-氨基-5-磷酸戊酸,0.5 mg/kg i.p.),对刺激的谷氨酸释放无显著影响。相反,在每次给药前20分钟注射AMPA受体拮抗剂CNQX(6-氰-7-硝基喹诺沙林- 2,3 -二酮,0.5 mg/kg i.p)可显著抑制吗啡诱导的VTA谷氨酸释放。在所有的实验中,谷氨酸的释放都随着时间的推移而减少。这些结果首次表明,急性和反复注射吗啡可通过AMPA受体刺激意识大鼠VTA中谷氨酸的释放。
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引用次数: 7
期刊
The Medical Journal of The Islamic Republic of Iran
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