Pub Date : 2024-05-04DOI: 10.29309/tpmj/2024.31.05.7512
Syed Muhammad Ali, Syed Mahmood Haider, Kashif Ikram, Zahid Ali, Syed Muhammad, Abdullah Salman, Raza Ali
Objective: To check the prevalence and causes of mandibular Fracture in the teaching hospital of Karachi Pakistan. Study Design: Crossectional, Observational, Retrprospective. Setting: Department of Oral & Maxillofacial Surgery, Karachi Medical and Dental College Abbasi Shaheed Hospital Karachi and Department of Oral and Maxillofacial Surgery Baqai Dental College University, Karachi. Period: 1st December 2018 to 30th November 2019. Methods: This study was based on randomly selected cases of one year of work at the Department of Oral and Maxillofacial Surgery Abbasi Shaheed Hospital Karachi and Department of Oral and Maxillofacial Surgery Baqai Dental College Baqai Medical University Karachi. Results: Road traffic accident like Bike accidents were top in position with 69 %, falls were next in position with 12 %, assault were recorded 10%, sports injuries were 7% and fire arm injuries2%. Mandibular fractures were found to occur at a rate of 22.1% in the parasymphysis, 12.8% in the body, 11.42% at the angle of the jaw, 12.1% in the condyle, 12.14% in the dento alveolar area, 6.4% in the symphysis, and 2.85 % in the ramus. Conclusion: To properly reduce and fix the fractures, a variety of treatment methods were employed. It has been determined that most patients were masculine and between the ages of 20 and 50. The most frequent locations for mandibular fractures were the parasymphysis and body, and the most common cause of trauma in the study participants was auto accidents.
{"title":"A retrospective study of mandibular fractures in tertiary care hospitals of Karachi.","authors":"Syed Muhammad Ali, Syed Mahmood Haider, Kashif Ikram, Zahid Ali, Syed Muhammad, Abdullah Salman, Raza Ali","doi":"10.29309/tpmj/2024.31.05.7512","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.7512","url":null,"abstract":"Objective: To check the prevalence and causes of mandibular Fracture in the teaching hospital of Karachi Pakistan. Study Design: Crossectional, Observational, Retrprospective. Setting: Department of Oral & Maxillofacial Surgery, Karachi Medical and Dental College Abbasi Shaheed Hospital Karachi and Department of Oral and Maxillofacial Surgery Baqai Dental College University, Karachi. Period: 1st December 2018 to 30th November 2019. Methods: This study was based on randomly selected cases of one year of work at the Department of Oral and Maxillofacial Surgery Abbasi Shaheed Hospital Karachi and Department of Oral and Maxillofacial Surgery Baqai Dental College Baqai Medical University Karachi. Results: Road traffic accident like Bike accidents were top in position with 69 %, falls were next in position with 12 %, assault were recorded 10%, sports injuries were 7% and fire arm injuries2%. Mandibular fractures were found to occur at a rate of 22.1% in the parasymphysis, 12.8% in the body, 11.42% at the angle of the jaw, 12.1% in the condyle, 12.14% in the dento alveolar area, 6.4% in the symphysis, and 2.85 % in the ramus. Conclusion: To properly reduce and fix the fractures, a variety of treatment methods were employed. It has been determined that most patients were masculine and between the ages of 20 and 50. The most frequent locations for mandibular fractures were the parasymphysis and body, and the most common cause of trauma in the study participants was auto accidents.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"183 1‐2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To evaluate the outcome of high-flow nasal cannula (HFNC) therapy by ROX index in critically ill children with acute respiratory failure due to lower respiratory tract infections in pediatric intensive care unit (PICU). Study Design: Analytical, Observational, Cross-sectional study. Setting: The PICU of the Indus Hospital, Karachi, Pakistan. Period: November 2022 to October 2023. Methods: We enrolled children of either gender, aged above 1 month up to 16 years and presenting with acute respiratory insufficiency due to lower respiratory tract infections. The use of HFNC was monitored for 72-hours. HFNC failure was characterized by requiring either noninvasive mechanical ventilation or invasive mechanical ventilation due to an unstable state. Results: In a total of 62 children, 39 (62.9%) were male. The mean age was 27.01±30.96 months. The most common diagnosis at the time of admission were pneumonia, and bronchiolitis noted in 25 (40.3%), and 33 (53.2%) children, respectively. Gradual improvement in ROX index was observed among children with HFNC success while a declining ROX index predicted HFNC failure. Outcome of HFNC was successful in 45 (72.6%) children. Mortality was observed in 12 (19.4%) children. Presence of comorbidity was significantly associated with unsuccessful HFNC outcomes. Conclusion: ROX index was found to be a good predictor of HFNC outcome. Overall, HFNC therapy in PICU demonstrated 72.6% success rate. HFNC outcomes are hampered particularly in cases involving comorbidities highlighting the need for tailored interventions.
{"title":"Outcome of high-flow nasal cannula (HFNC) therapy in respiratory failure due to lower respiratory tract infections in PICU - a single center experience in Karachi, Pakistan.","authors":"Humaira Mustafa, Rabeea Tariq, Najmi Usman, Sadiq Mirza, Anwarul Haque, Sahrish Ameer","doi":"10.29309/tpmj/2024.31.05.8115","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8115","url":null,"abstract":"Objective: To evaluate the outcome of high-flow nasal cannula (HFNC) therapy by ROX index in critically ill children with acute respiratory failure due to lower respiratory tract infections in pediatric intensive care unit (PICU). Study Design: Analytical, Observational, Cross-sectional study. Setting: The PICU of the Indus Hospital, Karachi, Pakistan. Period: November 2022 to October 2023. Methods: We enrolled children of either gender, aged above 1 month up to 16 years and presenting with acute respiratory insufficiency due to lower respiratory tract infections. The use of HFNC was monitored for 72-hours. HFNC failure was characterized by requiring either noninvasive mechanical ventilation or invasive mechanical ventilation due to an unstable state. Results: In a total of 62 children, 39 (62.9%) were male. The mean age was 27.01±30.96 months. The most common diagnosis at the time of admission were pneumonia, and bronchiolitis noted in 25 (40.3%), and 33 (53.2%) children, respectively. Gradual improvement in ROX index was observed among children with HFNC success while a declining ROX index predicted HFNC failure. Outcome of HFNC was successful in 45 (72.6%) children. Mortality was observed in 12 (19.4%) children. Presence of comorbidity was significantly associated with unsuccessful HFNC outcomes. Conclusion: ROX index was found to be a good predictor of HFNC outcome. Overall, HFNC therapy in PICU demonstrated 72.6% success rate. HFNC outcomes are hampered particularly in cases involving comorbidities highlighting the need for tailored interventions.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.29309/tpmj/2024.31.05.8111
Sidra Mahmood, Mohsina Noor, Marya Hameed
Objective: To evaluate the spectrum of skeletal dysplasia in short stature children at National Institute of Child Health (NICH), Pakistan. Study Design: Case Series study. Setting: Department of Endocrinology, NICH, Karachi, Pakistan. Period: January 2022 to November 2023. Methods: Short statured (height < -2.0 SD) children of either gender aged between 1 month up to 16 years and diagnosed with skeletal dysplasia were analyzed. At the time enrollment, gender, age, anthropometric measures, antenatal history, and family history were noted. Complete skeletal survey was performed. Results: In a total of 131 short statured children with skeletal dysplasia, 77 (58.8%) were male. The mean and median age were 5.54±4.33 and 5.0 (1.5-8) years. Consanguinity was reported in 85 (64.9%) cases whereas siblings were affected among 9 (6.9%) cases. The most frequent presenting complaints and clinical features were joint pain, facial dysmorphism, movement limitations, and infections, reported by 67 (51.1%), 67 (51.1%), 65 (49.6%), and 63 (48.1%) children respectively. Mucopolysaccharidosis (29.0%), achondrodysplasia (13.7%), and osteogenesis imperfecta (10.7%) were the most common types of skeletal dysplasia. Conclusion: Mucopolysaccharidosis, achondrodysplasia, and osteogenesis imperfecta were the most frequent types of skeletal dysplasia. The most frequent presenting complaints and clinical features were joint pain, facial dysmorphism, movement limitations, and infections. The high prevalence of consanguinity and familial history emphasizes a probable genetic basis for skeletal dysplasia.
{"title":"Spectrum of skeletal dysplasia in short stature children in tertiary care hospital.","authors":"Sidra Mahmood, Mohsina Noor, Marya Hameed","doi":"10.29309/tpmj/2024.31.05.8111","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8111","url":null,"abstract":"Objective: To evaluate the spectrum of skeletal dysplasia in short stature children at National Institute of Child Health (NICH), Pakistan. Study Design: Case Series study. Setting: Department of Endocrinology, NICH, Karachi, Pakistan. Period: January 2022 to November 2023. Methods: Short statured (height < -2.0 SD) children of either gender aged between 1 month up to 16 years and diagnosed with skeletal dysplasia were analyzed. At the time enrollment, gender, age, anthropometric measures, antenatal history, and family history were noted. Complete skeletal survey was performed. Results: In a total of 131 short statured children with skeletal dysplasia, 77 (58.8%) were male. The mean and median age were 5.54±4.33 and 5.0 (1.5-8) years. Consanguinity was reported in 85 (64.9%) cases whereas siblings were affected among 9 (6.9%) cases. The most frequent presenting complaints and clinical features were joint pain, facial dysmorphism, movement limitations, and infections, reported by 67 (51.1%), 67 (51.1%), 65 (49.6%), and 63 (48.1%) children respectively. Mucopolysaccharidosis (29.0%), achondrodysplasia (13.7%), and osteogenesis imperfecta (10.7%) were the most common types of skeletal dysplasia. Conclusion: Mucopolysaccharidosis, achondrodysplasia, and osteogenesis imperfecta were the most frequent types of skeletal dysplasia. The most frequent presenting complaints and clinical features were joint pain, facial dysmorphism, movement limitations, and infections. The high prevalence of consanguinity and familial history emphasizes a probable genetic basis for skeletal dysplasia.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"188 1‐2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.29309/tpmj/2024.31.05.8075
Sohail Anjum, Sarah Hafeez Malik, Nighat Nadeem, Sohail Bashir Sulehria
Objective: (1)To analyze of efficacy of metformin in pregnant women with POCS regarding occurrence of gestational diabetes mellitus (2) To analyze parity distribution for efficacy of metformin regarding occurrence of gestational diabetes mellitus in pregnant women with POCS. Study Design: Descriptive Cases Series. Setting: Sheikh Zaid Hospital, Lahore. Period: July 1, 2019 to December 31, 2019. Methods: Till delivery 200 pregnant ladies were followed up to see if they developed GDM or not. A pre-prepared form was used to record metformin efficacy frequency and GDM in pregnant ladies with PCOS. For efficacy and parity (qualitative variables), percentages and frequencies were got calculated using SPSS.16. Results: Thirty two (16%) women got ‘0’ parity. Forty four (22%) got ‘1’parity. Fifty (25%) got ‘2’ parity. Forty two (21%) got ‘3’parity.While thirty two women (16%) got ‘4’ parity. Twenty two (78.57%) was efficacy for nulliparous patients. Thirty three (76.74%) was efficacy for primiparous patients. One hundred nine (84.50%) was efficacy for multiparous patients. Insignificant difference was noted as p was more than 0.05. In one hundred sixty six (83%) women metformin efficacy got achieved. Conclusion: Multiparous patients with PCOS showed relatively more efficacy (84.50%) of metformin against gestational diabetes mellitus while twenty five percent pregnant women with PCOS with a thorough use of metformin delivered two live neonates.
{"title":"Analysis of efficacy of metformin in pregnant women with Polycystic Ovarian Syndrome (PCOS).","authors":"Sohail Anjum, Sarah Hafeez Malik, Nighat Nadeem, Sohail Bashir Sulehria","doi":"10.29309/tpmj/2024.31.05.8075","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8075","url":null,"abstract":"Objective: (1)To analyze of efficacy of metformin in pregnant women with POCS regarding occurrence of gestational diabetes mellitus (2) To analyze parity distribution for efficacy of metformin regarding occurrence of gestational diabetes mellitus in pregnant women with POCS. Study Design: Descriptive Cases Series. Setting: Sheikh Zaid Hospital, Lahore. Period: July 1, 2019 to December 31, 2019. Methods: Till delivery 200 pregnant ladies were followed up to see if they developed GDM or not. A pre-prepared form was used to record metformin efficacy frequency and GDM in pregnant ladies with PCOS. For efficacy and parity (qualitative variables), percentages and frequencies were got calculated using SPSS.16. Results: Thirty two (16%) women got ‘0’ parity. Forty four (22%) got ‘1’parity. Fifty (25%) got ‘2’ parity. Forty two (21%) got ‘3’parity.While thirty two women (16%) got ‘4’ parity. Twenty two (78.57%) was efficacy for nulliparous patients. Thirty three (76.74%) was efficacy for primiparous patients. One hundred nine (84.50%) was efficacy for multiparous patients. Insignificant difference was noted as p was more than 0.05. In one hundred sixty six (83%) women metformin efficacy got achieved. Conclusion: Multiparous patients with PCOS showed relatively more efficacy (84.50%) of metformin against gestational diabetes mellitus while twenty five percent pregnant women with PCOS with a thorough use of metformin delivered two live neonates.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"58 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.29309/tpmj/2024.31.05.8093
Mobin Inam Pal, Saeed Akbar Tariq, K. Naheed, Ayesha Ayub, Ehsan Ahmad, Zunera Misbah
Objective: To assess the pattern of unnatural deaths in Faisalabad during the last five years, to determine the gender and age group mostly affected and to explore the increasing trend if any. Study Design: Retrospective Cross-sectional Descriptive study. Setting: Department of Forensic Medicine and Toxicology, Punjab Medical College, Faisalabad. Period: January 2018 to December 2022. Methods: Subjects of the study were victims of unnatural death in areas covered by Police stations where the postmortem was performed in the Mortuary of Punjab Medical College / Faisalabad Medical University. Data was collected from respective official Police records, FIRs and Postmortem reports and recorded on pre-structured proformas. It was categorized on the basis of manner of death, type of weapon involved, age groups involved and gender. Results: Out of a total of 1340 autopsies conducted, 1024(76.4%) were males and 316(23.6%) were females. The male to female ratio was 3.2:1. Majority of the victims belonged to the 30–39-year age group i.e. 338 (25.2%) followed by the 20-29-year age group with 333 (24.8%) cases. The manner of death was homicidal in 896(67%) cases followed by 320(24%) accidental and 77(6%) of suicide. Firearm was the most commonly used weapon claiming 490 (36.6%) lives followed by RTA with 254 (19%) cases. September was the month in which maximum cases were reported (140,10.4%). Conclusion: Males are the major victims of unnatural deaths, with firearm weapons claiming the majority of lives. There is a rising trend in the number of unnatural deaths as the years go by and strict measures need to be implemented to keep a check and balance on the availability and easy access to firearms and strict traffic rules should be implemented.
{"title":"Comparative analysis of unnatural deaths in Faisalabad during 2018-2022 – A raising trend.","authors":"Mobin Inam Pal, Saeed Akbar Tariq, K. Naheed, Ayesha Ayub, Ehsan Ahmad, Zunera Misbah","doi":"10.29309/tpmj/2024.31.05.8093","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8093","url":null,"abstract":"Objective: To assess the pattern of unnatural deaths in Faisalabad during the last five years, to determine the gender and age group mostly affected and to explore the increasing trend if any. Study Design: Retrospective Cross-sectional Descriptive study. Setting: Department of Forensic Medicine and Toxicology, Punjab Medical College, Faisalabad. Period: January 2018 to December 2022. Methods: Subjects of the study were victims of unnatural death in areas covered by Police stations where the postmortem was performed in the Mortuary of Punjab Medical College / Faisalabad Medical University. Data was collected from respective official Police records, FIRs and Postmortem reports and recorded on pre-structured proformas. It was categorized on the basis of manner of death, type of weapon involved, age groups involved and gender. Results: Out of a total of 1340 autopsies conducted, 1024(76.4%) were males and 316(23.6%) were females. The male to female ratio was 3.2:1. Majority of the victims belonged to the 30–39-year age group i.e. 338 (25.2%) followed by the 20-29-year age group with 333 (24.8%) cases. The manner of death was homicidal in 896(67%) cases followed by 320(24%) accidental and 77(6%) of suicide. Firearm was the most commonly used weapon claiming 490 (36.6%) lives followed by RTA with 254 (19%) cases. September was the month in which maximum cases were reported (140,10.4%). Conclusion: Males are the major victims of unnatural deaths, with firearm weapons claiming the majority of lives. There is a rising trend in the number of unnatural deaths as the years go by and strict measures need to be implemented to keep a check and balance on the availability and easy access to firearms and strict traffic rules should be implemented.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"140 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.29309/tpmj/2024.31.05.8118
Nazia Arain, Fakhir Raza, Haidri, Bushra Zafar, Ravi Kumar, Abdul Rehman Azam, Sumera Imran
Objective: To estimate the incidence and risk factors of delirium in intensive care unit (ICU) of Sindh Institute of Urology and Transplantation (SIUT), Karachi. Study Design: Cross-sectional study. Setting: The ICU of SIUT, Karachi, Pakistan. Period: February 2023 to August, 2023. Methods: Patients over 18 years of age who were admitted to the ICU for more than 24 hours were analyzed. Patient with Richmond agitation sedation score (RASS >-2) were assessed for delirium using the confusion assessment method (CAM)-ICU method. Delirium subtypes were also evaluated. Domographic and clinical risk factors were evaluated for possible relationship with the existence of delirium. Results: Total 96 patient were enrolled in the study, 64 (66.7%) were male and 32 (33.3%) female. The mean age was 49.1±17.3 years. Mean RASS and CAM-ICU scores were 0.53±1.31 and 1.0±1.42 respectively. Delirium was present in 32 (33.3%) patients. It was noted that 45.4% patients had hypoactive delirium, 31.8% hyperactive delirium, and 22.7% mixed type. Patients aged 50 years or above had higher odds of delirium (OR: 0.41 [0.17-0.98], p=0.045), On multivariable regression model, BMI <25 Kg/m2, coexistence of ischemic heart disease and chronic kidney disease, patients with septic shock, post-operative patients, need of sedation were significantly associated with higher odds of delirium. Conclusion: Delirium is a frequent condition in ICU patients, with a higher occurrence of hypoactive delirium. The leading risk factors associated with delirium were older age, ischemic heart disease, chronic kidney disease and use of sedative drugs.
{"title":"Incidence and risk factors of delirium in the intensive care unit of SIUT Karachi.","authors":"Nazia Arain, Fakhir Raza, Haidri, Bushra Zafar, Ravi Kumar, Abdul Rehman Azam, Sumera Imran","doi":"10.29309/tpmj/2024.31.05.8118","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8118","url":null,"abstract":"Objective: To estimate the incidence and risk factors of delirium in intensive care unit (ICU) of Sindh Institute of Urology and Transplantation (SIUT), Karachi. Study Design: Cross-sectional study. Setting: The ICU of SIUT, Karachi, Pakistan. Period: February 2023 to August, 2023. Methods: Patients over 18 years of age who were admitted to the ICU for more than 24 hours were analyzed. Patient with Richmond agitation sedation score (RASS >-2) were assessed for delirium using the confusion assessment method (CAM)-ICU method. Delirium subtypes were also evaluated. Domographic and clinical risk factors were evaluated for possible relationship with the existence of delirium. Results: Total 96 patient were enrolled in the study, 64 (66.7%) were male and 32 (33.3%) female. The mean age was 49.1±17.3 years. Mean RASS and CAM-ICU scores were 0.53±1.31 and 1.0±1.42 respectively. Delirium was present in 32 (33.3%) patients. It was noted that 45.4% patients had hypoactive delirium, 31.8% hyperactive delirium, and 22.7% mixed type. Patients aged 50 years or above had higher odds of delirium (OR: 0.41 [0.17-0.98], p=0.045), On multivariable regression model, BMI <25 Kg/m2, coexistence of ischemic heart disease and chronic kidney disease, patients with septic shock, post-operative patients, need of sedation were significantly associated with higher odds of delirium. Conclusion: Delirium is a frequent condition in ICU patients, with a higher occurrence of hypoactive delirium. The leading risk factors associated with delirium were older age, ischemic heart disease, chronic kidney disease and use of sedative drugs.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"33 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.29309/tpmj/2024.31.05.7959
Maria Naseer, Salahuddin Balooch, Umar Amin, Muhammad Amin, Muhammad Usman Khan, Madeeha Anwar
Objective: To assess the diagnostic accuracy of high resolution computed tomography (HRCT) of chest in diagnosing sputum smear positive and negative pulmonary tuberculosis (PTB). Study Design: Cross-sectional study. Setting: Tertiary Care Hospital, Kharian Cantt. Period: Oct 2021 to April 2022. Methods: The retrospective reviews of medical records of patients undergone HRCT chest and sputum for AFB smear and culture due to pulmonary tuberculosis (PTB) suspicion were included. The HRCT and AFB findings for sample size of 220 was compared. SPSS was used to stratify outcomes on basis of sputum smear results. Diagnostic accuracy of HRCT chest was calculated by taking AFB as gold standard. The AFB findings and HRCT outcomes were compared through correlation analysis and paired t-test with p value < 0.05 considered as significant. Results: The sensitivity was found to be 86.23% with specificity of 86.48%, positive predictive value of 86.23%, negative predictive value of 86.48% and diagnostic accuracy of 86.36% for HRCT for diagnosing pulmonary tuberculosis (PTB). Conclusion: HRCT chest affirms high diagnostic potential for pulmonary tuberculosis (PTB) and should be used as a routine diagnostic tool for the disease.
{"title":"Diagnostic accuracy of high resolution computed tomography (HRCT) of chest in diagnosing sputum smear positive and sputum smear negative pulmonary tuberculosis (PTB).","authors":"Maria Naseer, Salahuddin Balooch, Umar Amin, Muhammad Amin, Muhammad Usman Khan, Madeeha Anwar","doi":"10.29309/tpmj/2024.31.05.7959","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.7959","url":null,"abstract":"Objective: To assess the diagnostic accuracy of high resolution computed tomography (HRCT) of chest in diagnosing sputum smear positive and negative pulmonary tuberculosis (PTB). Study Design: Cross-sectional study. Setting: Tertiary Care Hospital, Kharian Cantt. Period: Oct 2021 to April 2022. Methods: The retrospective reviews of medical records of patients undergone HRCT chest and sputum for AFB smear and culture due to pulmonary tuberculosis (PTB) suspicion were included. The HRCT and AFB findings for sample size of 220 was compared. SPSS was used to stratify outcomes on basis of sputum smear results. Diagnostic accuracy of HRCT chest was calculated by taking AFB as gold standard. The AFB findings and HRCT outcomes were compared through correlation analysis and paired t-test with p value < 0.05 considered as significant. Results: The sensitivity was found to be 86.23% with specificity of 86.48%, positive predictive value of 86.23%, negative predictive value of 86.48% and diagnostic accuracy of 86.36% for HRCT for diagnosing pulmonary tuberculosis (PTB). Conclusion: HRCT chest affirms high diagnostic potential for pulmonary tuberculosis (PTB) and should be used as a routine diagnostic tool for the disease.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"73 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.29309/tpmj/2024.31.05.8053
Samrah Ibrahim, Misbah Anjum, Shazia Soomro
Objective: To determine the risk factors, clinical presentation and short term outcome in children presenting with arterial ischemic stroke at a tertiary care hospital. Study Design: Prospective Observational study. Setting: Medical Units of National Institute of Child Health, Karachi, Pakistan. Period: November 2022 October 2023. Methods: Children of either gender aged between 1 month to 12 years and admitted with the diagnosis of pediatric arterial ischemic stroke during the study duration were analyzed. Detailed medical and neurological examinations were performed. Routine work up and laboratory investigations were done. Modified Rankin Scale (MRS) scores at the time of enrollment, discharge and after 3 month follow-up were recorded. Results: In a total of 35 children, 21 (60.0%) were boys the mean age was 6.89±3.63 years. The most frequent presenting clinical features were focal neurological deficits noted in 29 (82.9%) children whereas fever, and fits were reported in 26 (74.3%), and 22 (62.9%) children, respectively. Right hemiplegia was observed in 15 (42.9%) children. Stroke was secondary to moyamoya 8 (22.9%), infections in 6 (17.1%) children. Mortality was reported among 3 (8.6%) children while 3 others lost during the follow ups. Comparison of mean mRS scores at the time of admission, discharge and after 3 months showed significant reduction (p<0.001). Conclusion: Focal neurological deficits were the predominant clinical features, with a significant incidence of associated fever and seizures. Moyamoya and infections emerged as primary causative factors. Despite a mortality rate of 8.6%, there was an overall improvement in outcomes, as evidenced by a significant reduction in Modified Rankin Scale scores at admission, discharge, and after three months.
{"title":"Pediatric arterial ischemic stroke; Risk factors, clinical presentation and short-term outcome of patients presenting at a tertiary care hospital.","authors":"Samrah Ibrahim, Misbah Anjum, Shazia Soomro","doi":"10.29309/tpmj/2024.31.05.8053","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8053","url":null,"abstract":"Objective: To determine the risk factors, clinical presentation and short term outcome in children presenting with arterial ischemic stroke at a tertiary care hospital. Study Design: Prospective Observational study. Setting: Medical Units of National Institute of Child Health, Karachi, Pakistan. Period: November 2022 October 2023. Methods: Children of either gender aged between 1 month to 12 years and admitted with the diagnosis of pediatric arterial ischemic stroke during the study duration were analyzed. Detailed medical and neurological examinations were performed. Routine work up and laboratory investigations were done. Modified Rankin Scale (MRS) scores at the time of enrollment, discharge and after 3 month follow-up were recorded. Results: In a total of 35 children, 21 (60.0%) were boys the mean age was 6.89±3.63 years. The most frequent presenting clinical features were focal neurological deficits noted in 29 (82.9%) children whereas fever, and fits were reported in 26 (74.3%), and 22 (62.9%) children, respectively. Right hemiplegia was observed in 15 (42.9%) children. Stroke was secondary to moyamoya 8 (22.9%), infections in 6 (17.1%) children. Mortality was reported among 3 (8.6%) children while 3 others lost during the follow ups. Comparison of mean mRS scores at the time of admission, discharge and after 3 months showed significant reduction (p<0.001). Conclusion: Focal neurological deficits were the predominant clinical features, with a significant incidence of associated fever and seizures. Moyamoya and infections emerged as primary causative factors. Despite a mortality rate of 8.6%, there was an overall improvement in outcomes, as evidenced by a significant reduction in Modified Rankin Scale scores at admission, discharge, and after three months.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"85 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To analyze the detection validity of serum biochemical markers in the suspicion of acute biliary disease. Study Design: Retrospective study. Setting: Department of Biochemistry, Islam Teaching Hospital, Sialkot. Period: January 2023 till June 2023. Methods: In a retrospective analysis of 70 patients, there were 35 patients suffering from acute biliary pancreatitis and 35 patients were suffering from non-biliary pancreatitis in group A and B respectively. The patients were identified based on high serum amylase levels. Age, gender, and history were examined, and patients with persistent abdominal pain and abnormal amylase levels were included. Computed tomography detected gallstones, and patients with chronic liver issues were excluded. Results: Comparative analysis conducted using Chi-square and Mann-Whitney tests in SPSS 15.0. A significant result was defined as a P value under 0.005. The sample collection was done from Islam teaching hospital Sialkot and the study was conducted at biochemistry lab of Islam medical college Sialkot. Conclusion: The study, involving 70 patients, aimed to predict acute biliary pancreatitis using serum biochemical markers. The two groups, one with acute biliary pancreatitis and other non-biliary, showed significant differences in key markers (total bilirubin, ALT, direct bilirubin, ALP, AST and serum amylase). These findings suggest the potential diagnostic relevance of these markers.
{"title":"The predictive validity of serum biochemical markers in case of acute biliary pancreatitis.","authors":"Adnan Riaz, Sumera Saghir, Roomana Anwar, Sabeen Khalid, Muhammad Shakil, Tabinda Fatima","doi":"10.29309/tpmj/2024.31.05.8003","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8003","url":null,"abstract":"Objective: To analyze the detection validity of serum biochemical markers in the suspicion of acute biliary disease. Study Design: Retrospective study. Setting: Department of Biochemistry, Islam Teaching Hospital, Sialkot. Period: January 2023 till June 2023. Methods: In a retrospective analysis of 70 patients, there were 35 patients suffering from acute biliary pancreatitis and 35 patients were suffering from non-biliary pancreatitis in group A and B respectively. The patients were identified based on high serum amylase levels. Age, gender, and history were examined, and patients with persistent abdominal pain and abnormal amylase levels were included. Computed tomography detected gallstones, and patients with chronic liver issues were excluded. Results: Comparative analysis conducted using Chi-square and Mann-Whitney tests in SPSS 15.0. A significant result was defined as a P value under 0.005. The sample collection was done from Islam teaching hospital Sialkot and the study was conducted at biochemistry lab of Islam medical college Sialkot. Conclusion: The study, involving 70 patients, aimed to predict acute biliary pancreatitis using serum biochemical markers. The two groups, one with acute biliary pancreatitis and other non-biliary, showed significant differences in key markers (total bilirubin, ALT, direct bilirubin, ALP, AST and serum amylase). These findings suggest the potential diagnostic relevance of these markers.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"28 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To assess the prevalence of adverse perinatal outcomes in antenatal women with low amniotic fluid index at term. Study Design: Observational Cross-sectional Analysis. Setting: Department of Gynaecology and Obstetrics Hayatabad Medical Complex, Peshawar. Period: 2nd February 2020, to 5th February 2021. Methods: The study involved a total of 165 patients, in 37 to 40-weeks of gestation period, the research included antenatal women with a low amniotic fluid index, with any parity, gravidity, and 18-35 years of age. While Excluded patients with any medical disorders during pregnancy (e.g., PIH, anemia, cardiac disease etc.), and those with gestational period <37 weeks from the study. Thorough history, clinical examination and ultrasound were carried out of all the women included in the study from OPD and emergency department, to confirm a low amniotic fluid index. Patient follow-up was extended to their arrival in the Obstetric suite during established labor, APGAR scores were calculated and recorded at birth, and at the 5-minute of birth for the neonate. Adverse Perinatal Outcome was considered positive if the APGAR Score was <7/10 at five minutes of life of neonate. Data analysis was performed using SPSS 23. Results: Out of 165 patients 57% of the patients were induced while 43% spontaneously delivered, similarly 66.7% were delivered vaginally while 33.3% were delivered via C Section. Low neonatal APGAR score was recorded in 67.9% patients which is a significant percentage, hence our study results showed positive correlation of low AFI with adverse perinatal outcome. We also observed that probability of satisfactory values of AFI is 1.5 times more in spontaneous deliveries (p=0.04, OR=1.5), however no such relation exists for period of gestation or number of parity. Similarly, there is a significant relation of mode of delivery with satisfactory values of AFI (p=0.00), however no such relation exists for period of gestation or number of parity. However, the probability of vaginal deliveries is 1.6 times more with an increased in number of para (p=0.02, OR=1.6). Conclusion: Reduced amniotic fluid index is linked with significant Unfavorable Perinatal Outcomes proved by low APGAR score (<7/10 at five minutes).
{"title":"Low amniotic fluid index at term as a predictor of adverse perinatal outcome.","authors":"Tehsina Ali, Kalsoom Habib Khattak, Safoora, Aneela Mumtaz, Dr. Kalsoom Habib Khattak","doi":"10.29309/tpmj/2024.31.05.8141","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8141","url":null,"abstract":"Objective: To assess the prevalence of adverse perinatal outcomes in antenatal women with low amniotic fluid index at term. Study Design: Observational Cross-sectional Analysis. Setting: Department of Gynaecology and Obstetrics Hayatabad Medical Complex, Peshawar. Period: 2nd February 2020, to 5th February 2021. Methods: The study involved a total of 165 patients, in 37 to 40-weeks of gestation period, the research included antenatal women with a low amniotic fluid index, with any parity, gravidity, and 18-35 years of age. While Excluded patients with any medical disorders during pregnancy (e.g., PIH, anemia, cardiac disease etc.), and those with gestational period <37 weeks from the study. Thorough history, clinical examination and ultrasound were carried out of all the women included in the study from OPD and emergency department, to confirm a low amniotic fluid index. Patient follow-up was extended to their arrival in the Obstetric suite during established labor, APGAR scores were calculated and recorded at birth, and at the 5-minute of birth for the neonate. Adverse Perinatal Outcome was considered positive if the APGAR Score was <7/10 at five minutes of life of neonate. Data analysis was performed using SPSS 23. Results: Out of 165 patients 57% of the patients were induced while 43% spontaneously delivered, similarly 66.7% were delivered vaginally while 33.3% were delivered via C Section. Low neonatal APGAR score was recorded in 67.9% patients which is a significant percentage, hence our study results showed positive correlation of low AFI with adverse perinatal outcome. We also observed that probability of satisfactory values of AFI is 1.5 times more in spontaneous deliveries (p=0.04, OR=1.5), however no such relation exists for period of gestation or number of parity. Similarly, there is a significant relation of mode of delivery with satisfactory values of AFI (p=0.00), however no such relation exists for period of gestation or number of parity. However, the probability of vaginal deliveries is 1.6 times more with an increased in number of para (p=0.02, OR=1.6). Conclusion: Reduced amniotic fluid index is linked with significant Unfavorable Perinatal Outcomes proved by low APGAR score (<7/10 at five minutes).","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"72 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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