Toshihiro Noguchi, Y. Ishii, Yuta Mitsui, Tomono Usami, Shuetsu Oikawa, Shigetoshi Nishihara, Kei Nakatani, Akihiro Nakayama, Hitoshi Yoshida
{"title":"Risk factors for cholecystitis after metal stent placement for distal malignant biliary obstruction","authors":"Toshihiro Noguchi, Y. Ishii, Yuta Mitsui, Tomono Usami, Shuetsu Oikawa, Shigetoshi Nishihara, Kei Nakatani, Akihiro Nakayama, Hitoshi Yoshida","doi":"10.15369/sujms.34.19","DOIUrl":"https://doi.org/10.15369/sujms.34.19","url":null,"abstract":"","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74478435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kanae Moriya, Hisanori Shimizu, D. Kamei, Satoko Handa, Tadanori Sasaki, Y. Kato
The combination drug S-1, which contains tegafur, gimeracil, and oteracil potassium, is a fluoropyrimidine-based oral antineoplastic agent in which the principal drug tegafur is a prodrug of fluorouracil （ 5-FU ） . In recent years, many studies have reported eye problems, especially corneal damage, as an adverse effect of S-1 treatment. In this study, we investigated the cytotoxic effects of each of the constituents of S-1 on corneal epithelial cells by measuring viable cell counts and lactate dehydrogenase （ LDH ） release. study for 5-FU and the constituents of S-1 （ i.e., tegafur, gimeracil, and oteracil ） using a human cell line. We used immortalized human epithelial （ HCE-T ） cells to estimate viable cell counts （ expressed as a percentage of the control cells ） and the activity of LDH in a culture medium （ expressed as a percentage of the total LDH activity ） . Decreases in viable cell counts were noted with 5-FU and tegafur, but a significant elevation in LDH activity was noted only with tegafur. corneal epithelium by 5-FU is involved in the corneal injury mechanism of S-1.
{"title":"Evaluation of corneal damage caused by the anticancer drug S-1 in human corneal epithelial cells","authors":"Kanae Moriya, Hisanori Shimizu, D. Kamei, Satoko Handa, Tadanori Sasaki, Y. Kato","doi":"10.15369/sujms.34.27","DOIUrl":"https://doi.org/10.15369/sujms.34.27","url":null,"abstract":"The combination drug S-1, which contains tegafur, gimeracil, and oteracil potassium, is a fluoropyrimidine-based oral antineoplastic agent in which the principal drug tegafur is a prodrug of fluorouracil （ 5-FU ） . In recent years, many studies have reported eye problems, especially corneal damage, as an adverse effect of S-1 treatment. In this study, we investigated the cytotoxic effects of each of the constituents of S-1 on corneal epithelial cells by measuring viable cell counts and lactate dehydrogenase （ LDH ） release. study for 5-FU and the constituents of S-1 （ i.e., tegafur, gimeracil, and oteracil ） using a human cell line. We used immortalized human epithelial （ HCE-T ） cells to estimate viable cell counts （ expressed as a percentage of the control cells ） and the activity of LDH in a culture medium （ expressed as a percentage of the total LDH activity ） . Decreases in viable cell counts were noted with 5-FU and tegafur, but a significant elevation in LDH activity was noted only with tegafur. corneal epithelium by 5-FU is involved in the corneal injury mechanism of S-1.","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83855050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kosei Yamashita, Y. Okada, M. Maeda, Taro Kamiya, T. Imai
{"title":"Importance of oral food challenge and identification of atopic dermatitis in child with Netherton syndrome: A case report","authors":"Kosei Yamashita, Y. Okada, M. Maeda, Taro Kamiya, T. Imai","doi":"10.15369/sujms.34.37","DOIUrl":"https://doi.org/10.15369/sujms.34.37","url":null,"abstract":"","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80784250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yoshiki Uchida, Yuji Sato, Toshiharu Shichita, Tokiko Osawa, Akio Isobe, Mayumi Terazawa, Yukiko Hatanaka, J. Furuya
{"title":"Comparison of three representative subjective evaluations of chewing function","authors":"Yoshiki Uchida, Yuji Sato, Toshiharu Shichita, Tokiko Osawa, Akio Isobe, Mayumi Terazawa, Yukiko Hatanaka, J. Furuya","doi":"10.15369/sujms.34.142","DOIUrl":"https://doi.org/10.15369/sujms.34.142","url":null,"abstract":"","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"172 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87313961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An extremely rare case of an isolated fracture of the orbital roof caused only by an eye contusion and a simultaneous blowout fracture, trapdoor type, which was operated on using the transpalpebral supraorbital rim approach was reported herein. The patient was a 35-yearold male who fell off the surfboard into the sea with the fin hitting hard the patient’s right eye. The patient had right ptosis, pain on looking upwards, and forehead paralysis. No bruises on the head or face other than the lower eyelid were noted. The orbital computed tomography scan showed that only the orbital roof was fractured, the bone fragments cranially deviated, and the orbital fat was incarcerated in the fracture site. The patient underwent surgery using the transpalpebral supraorbital rim approach on day 14 postinjury. The fracture was of the trapdoor type, and the orbital fat, levator palpebrae superioris muscle, and supraorbital nerve were strangulated at the fracture site. Ptosis and eye movement disorder quickly improved postoperatively. Isolated orbital roof blowout fracture, trapdoor type, is a rare condition, and the fracture can be repaired using the transpalpebral approach in the absence of intracranial lesions and extensive bony deviation.
{"title":"A case of isolated blowout fracture of the orbital roof, trapdoor type, repaired using the transpalpebral approach","authors":"H. Onda","doi":"10.15369/sujms.34.41","DOIUrl":"https://doi.org/10.15369/sujms.34.41","url":null,"abstract":"An extremely rare case of an isolated fracture of the orbital roof caused only by an eye contusion and a simultaneous blowout fracture, trapdoor type, which was operated on using the transpalpebral supraorbital rim approach was reported herein. The patient was a 35-yearold male who fell off the surfboard into the sea with the fin hitting hard the patient’s right eye. The patient had right ptosis, pain on looking upwards, and forehead paralysis. No bruises on the head or face other than the lower eyelid were noted. The orbital computed tomography scan showed that only the orbital roof was fractured, the bone fragments cranially deviated, and the orbital fat was incarcerated in the fracture site. The patient underwent surgery using the transpalpebral supraorbital rim approach on day 14 postinjury. The fracture was of the trapdoor type, and the orbital fat, levator palpebrae superioris muscle, and supraorbital nerve were strangulated at the fracture site. Ptosis and eye movement disorder quickly improved postoperatively. Isolated orbital roof blowout fracture, trapdoor type, is a rare condition, and the fracture can be repaired using the transpalpebral approach in the absence of intracranial lesions and extensive bony deviation.","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89376778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tatsuya Iida, Hikaru Yonemura, H. Nishiwaki, Tomoaki Miyazaki, Hideyuki Imai, Chiho Sugisawa, F. Koiwa, S. Nagasaka
{"title":"A patient with type 1 diabetes mellitus who developed exogenous insulin antibody syndrome ameliorated by immunosuppressive treatment for concomitant systemic lupus erythematosus: A case report","authors":"Tatsuya Iida, Hikaru Yonemura, H. Nishiwaki, Tomoaki Miyazaki, Hideyuki Imai, Chiho Sugisawa, F. Koiwa, S. Nagasaka","doi":"10.15369/sujms.34.225","DOIUrl":"https://doi.org/10.15369/sujms.34.225","url":null,"abstract":"","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91260217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Changes in Sequential Organ Failure Assessment sub-scores as predictors of mortality in patients with septic acute kidney injury requiring continuous renal replacement therapy","authors":"M. Abe, Misa Ikeda-Taniguchi, H. Honda","doi":"10.15369/sujms.34.159","DOIUrl":"https://doi.org/10.15369/sujms.34.159","url":null,"abstract":"","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73022541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Miyaura, K. Murakami, Hiroyuki Watanabe, Yoshinori Ito, Y. Kagami
Understanding respiratory motion is necessary for accurate dose administration during stereotactic body radiation therapy. Although four-dimensional (4D) computed tomography (4DCT) is useful for understanding respiratory movements, 4D radiotherapy with a time axis is required. However, reports on the evaluation of 4DCT remain lacking. Therefore, this study was designed to evaluate the basic physical characteristics of a respiratory-gated 4DCT helical scanning system (4D-HS) using MATLABR. In this study, the physical characteristics were evaluated by examining the body-axis direction resolution, slice sensitivity profile (SSP), and volume change due to respiratory phase change and comparing multiplanar reconstruction profiles (MPRs) of slit phantoms. These characteristics were compared using normal helical scanning (N-HS). A 31% overestimation was observed in the volume fluctuation of 4D-HS based on the volume of N-HS. Furthermore, SSP with full width at half maximum (FWHM) and modulation transfer function (MTF) showed a similar resolution between 4D-HS and N-HS. The difference in FWHM is considered an offset by the voxel effect. In the MPR comparison, both 4D-HS and N-HS were visually identifiable up to a 0.5-mm slit. 4D-HS is a reconstruction system with excellent temporal resolution. Furthermore, its resolution follows respiratory dynamics and can continuously collect respiratory dynamics components. Our findings suggest the usefulness of 4D-HS in clinical practice.
{"title":"Basic analysis of optimal images for the development of 4D radiotherapy system","authors":"K. Miyaura, K. Murakami, Hiroyuki Watanabe, Yoshinori Ito, Y. Kagami","doi":"10.15369/sujms.34.11","DOIUrl":"https://doi.org/10.15369/sujms.34.11","url":null,"abstract":"Understanding respiratory motion is necessary for accurate dose administration during stereotactic body radiation therapy. Although four-dimensional (4D) computed tomography (4DCT) is useful for understanding respiratory movements, 4D radiotherapy with a time axis is required. However, reports on the evaluation of 4DCT remain lacking. Therefore, this study was designed to evaluate the basic physical characteristics of a respiratory-gated 4DCT helical scanning system (4D-HS) using MATLABR. In this study, the physical characteristics were evaluated by examining the body-axis direction resolution, slice sensitivity profile (SSP), and volume change due to respiratory phase change and comparing multiplanar reconstruction profiles (MPRs) of slit phantoms. These characteristics were compared using normal helical scanning (N-HS). A 31% overestimation was observed in the volume fluctuation of 4D-HS based on the volume of N-HS. Furthermore, SSP with full width at half maximum (FWHM) and modulation transfer function (MTF) showed a similar resolution between 4D-HS and N-HS. The difference in FWHM is considered an offset by the voxel effect. In the MPR comparison, both 4D-HS and N-HS were visually identifiable up to a 0.5-mm slit. 4D-HS is a reconstruction system with excellent temporal resolution. Furthermore, its resolution follows respiratory dynamics and can continuously collect respiratory dynamics components. Our findings suggest the usefulness of 4D-HS in clinical practice.","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76393608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Igawa, Yoshitaka Watanabe, M. Murase, Takanari Fujii, Hirokazu Ikeda
{"title":"Interrupted aortic arch without differential cyanosis due to aberrant subclavian artery","authors":"Y. Igawa, Yoshitaka Watanabe, M. Murase, Takanari Fujii, Hirokazu Ikeda","doi":"10.15369/sujms.34.221","DOIUrl":"https://doi.org/10.15369/sujms.34.221","url":null,"abstract":"","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83109561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eiichiro Minemura, Yohei Takeuchi, Y. Manome, H. Kimura, N. Inou, K. Maki
{"title":"An advanced method of individual jaw movement analysis","authors":"Eiichiro Minemura, Yohei Takeuchi, Y. Manome, H. Kimura, N. Inou, K. Maki","doi":"10.15369/sujms.34.200","DOIUrl":"https://doi.org/10.15369/sujms.34.200","url":null,"abstract":"","PeriodicalId":23019,"journal":{"name":"The Showa University Journal of Medical Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73413206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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