Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544916
O. Razumnikova, A. Yashanina
Cognitive intervention research focused on enhancing brain plasticity in healthy or mildly impaired older adults using training of different functions, such as mental speed, working memory or attention. As the age-related impairment of memory and executive functions is associated with decrease in inhibitory control, we investigated age-related inhibition effect after computer-based measuring and free self-determined program of these functions training in groups of younger and older adults. The findings demonstrate training-induced more slowly improvement of both memory and mental speed as well as reduced the inhibition-deficit in older than younger adults. Independently from age, different implicitly created strategies of remembering by retrieval-induced forgetting or forward effect of testing was revealed. Cognitive training induced the increased memory retrieval in younger with dominated forward effect of testing but in the seniors with pronounced inhibition function. So, computerized memory training differently stimulates cognitive reserves due to learning effect in younger and restored inhibition in older adults.
{"title":"Age-related changes in inhibition after cognitive training","authors":"O. Razumnikova, A. Yashanina","doi":"10.1109/CSGB.2018.8544916","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544916","url":null,"abstract":"Cognitive intervention research focused on enhancing brain plasticity in healthy or mildly impaired older adults using training of different functions, such as mental speed, working memory or attention. As the age-related impairment of memory and executive functions is associated with decrease in inhibitory control, we investigated age-related inhibition effect after computer-based measuring and free self-determined program of these functions training in groups of younger and older adults. The findings demonstrate training-induced more slowly improvement of both memory and mental speed as well as reduced the inhibition-deficit in older than younger adults. Independently from age, different implicitly created strategies of remembering by retrieval-induced forgetting or forward effect of testing was revealed. Cognitive training induced the increased memory retrieval in younger with dominated forward effect of testing but in the seniors with pronounced inhibition function. So, computerized memory training differently stimulates cognitive reserves due to learning effect in younger and restored inhibition in older adults.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134532478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544810
M. Smagin, A. Demura, O. Shumkov, M. Soluyanov, O. Poveshenko, V. Nimaev
The analysis of the use of platelet- riched plasma (PRP) in the treatment of chronic non-healing ulcers of lower limbs 41 completed case of treatment of patients with trophic ulcers. Two-fold administration of PRP leads to an acceleration of healing of ulcerative defects by 31.4% compared to the control group.
{"title":"Platelet-rich plasma in treatment of non-healing ulcers","authors":"M. Smagin, A. Demura, O. Shumkov, M. Soluyanov, O. Poveshenko, V. Nimaev","doi":"10.1109/CSGB.2018.8544810","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544810","url":null,"abstract":"The analysis of the use of platelet- riched plasma (PRP) in the treatment of chronic non-healing ulcers of lower limbs 41 completed case of treatment of patients with trophic ulcers. Two-fold administration of PRP leads to an acceleration of healing of ulcerative defects by 31.4% compared to the control group.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"219 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115598517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544807
M. Korolev, N. E. Banshchikova, E. Letyagina, V. Omelchenko, O. Poveshchenko, A. Lykov, M. Surovtseva
The search for new biomarkers that will allow the diagnosis of arthritis in the early, pre-destructive phase of the disease is still underway. Twenty two patients with early rheumatoid arthritis (RA), duration of the disease up to 12 months) were included in the study. Fifteen patient patients comprised a group of late rheumatoid arthritis. Eighteen patients with OA and without inflammatory arthropathy had formed the control group. Analysis of the B-lymphocytes, myeloid, and plasmacytoid DCs count was carried out using a flow cytofluorimeter (BD FACSCantoII, USA) and FacsDiva software. The percent of plasmacytoid DCs was statistically significant predominated in the group of patients with early and late RA in comparison with the control group - 3.8 * 10% and 9.0 * 10% vs 1.0 * 10%, respectively (p = 0.0042). Furthermore, the difference was found in the percent of cells with the phenotype B-lymphocytes: 7.95 * 10% and 7.7 * 10% vs 3.3* 10%, respectively (p = 0.014). The dynamics was detected due to a decrease in the percent of plasmacytoid dendritic cells and B-lymphocytes in patients in the group with early rheumatoid arthritis: respectively 3.5 * 10% vs 0.6 * 10% (statistically not significant, p> 0.05), and 6.9 * 106 / l vs 4.9 * 10% (p= 0.045). These data demonstrate the difference in the peripheral blood DCs subtypes ratio in group with early and late RA compared with OA- patients. These cellular markers can be used for early diagnosis, evaluation the activity and treatment effectiveness in patient with RA.
寻找新的生物标志物，以便在疾病的早期、破坏前阶段诊断关节炎，目前仍在进行中。22例早期类风湿关节炎(RA)患者(病程长达12个月)被纳入研究。15名患者组成一组晚期类风湿关节炎患者。无炎性关节病的OA患者18例作为对照组。使用流式细胞荧光仪(BD FACSCantoII，美国)和FacsDiva软件分析b淋巴细胞、髓细胞和浆细胞样DCs计数。与对照组相比，早、晚期RA组浆细胞样dc的比例分别为3.8 * 10%和9.0 * 10%，差异有统计学意义(p = 0.0042)。b型淋巴细胞的比例分别为7.95 * 10%和7.7 * 10% vs 3.3* 10% (p = 0.014)。类风湿关节炎早期患者浆细胞样树突状细胞和b淋巴细胞百分比下降，分别为3.5 * 10% vs 0.6 * 10%(无统计学意义，p> 0.05)， 6.9 * 106 / l vs 4.9 * 10% (p= 0.045)。这些数据表明，与OA患者相比，早期和晚期RA患者外周血dc亚型比例存在差异。这些细胞标志物可用于RA患者的早期诊断、活性评价和治疗效果评价。
{"title":"Phenotypes of peripheral dendritic cells in patients with early rheumatoid arthritis","authors":"M. Korolev, N. E. Banshchikova, E. Letyagina, V. Omelchenko, O. Poveshchenko, A. Lykov, M. Surovtseva","doi":"10.1109/CSGB.2018.8544807","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544807","url":null,"abstract":"The search for new biomarkers that will allow the diagnosis of arthritis in the early, pre-destructive phase of the disease is still underway. Twenty two patients with early rheumatoid arthritis (RA), duration of the disease up to 12 months) were included in the study. Fifteen patient patients comprised a group of late rheumatoid arthritis. Eighteen patients with OA and without inflammatory arthropathy had formed the control group. Analysis of the B-lymphocytes, myeloid, and plasmacytoid DCs count was carried out using a flow cytofluorimeter (BD FACSCantoII, USA) and FacsDiva software. The percent of plasmacytoid DCs was statistically significant predominated in the group of patients with early and late RA in comparison with the control group - 3.8 * 10% and 9.0 * 10% vs 1.0 * 10%, respectively (p = 0.0042). Furthermore, the difference was found in the percent of cells with the phenotype B-lymphocytes: 7.95 * 10% and 7.7 * 10% vs 3.3* 10%, respectively (p = 0.014). The dynamics was detected due to a decrease in the percent of plasmacytoid dendritic cells and B-lymphocytes in patients in the group with early rheumatoid arthritis: respectively 3.5 * 10% vs 0.6 * 10% (statistically not significant, p> 0.05), and 6.9 * 106 / l vs 4.9 * 10% (p= 0.045). These data demonstrate the difference in the peripheral blood DCs subtypes ratio in group with early and late RA compared with OA- patients. These cellular markers can be used for early diagnosis, evaluation the activity and treatment effectiveness in patient with RA.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117331349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544862
D. Bulumbaeva, V. Klimontov, N. Bgatova, Y. Taskaeva, O. Fazullina, N. B. Orlov, V. Konenkov, M. Soluyanov, S. Savchenko
The aim: to determine the relationships between serum levels of adipokines, body fat distribution, and the density and ultrastructure of blood and lymphatic microvessels in subcutaneous adipose tissue (AT) in type 2 diabetic subjects. Materials and Methods: We observed 125 patients, including 82 ones with obesity, and 30 lean non-diabetic individuals. The concentrations of leptin, resistin, visfatin, adipsin, and adiponectin in the fasting serum were determined by Multiplex analysis. The fat mass and AT distribution was assessed by DEXA. The samples of subcutaneous abdominal AT were obtained with the knife biopsy in 25 patients and in 15 healthy subjects. Immunohistochemistry for biomarkers CD-34, podoplanin and LYVE-1 was applied to identify the blood and lymphatic microvessels. Results: Patients with diabetes, as compared to control, had significantly higher levels of leptin (p=0.004), resistin (p<0.0001), adipsin (p<0.0001) and visfatin (p=0.0003). The concentrations of leptin, resistin and adipsin were associated with total fat mass. The levels of resistin and adiponectin demonstrated relationships with truncal and central abdominal fat mass. The increase in leptin levels in patients with type 2 diabetes and obesity was associated with a decrease in the volume and numeral density of the blood and lymph microvessels in the subcutaneous fat (r=-0.63, p=0.02; r=-0.55, p=0.05). The level of resistin was negatively correlated with the numeral density of lymphatic vessels (r=-0.59, p=0.03). Conclusion: The levels of circulating adipokines in patients with type 2 diabetes are related differently with body fat distribution and AT microvessel density.
目的:确定2型糖尿病患者血清脂肪因子水平、体脂分布、皮下脂肪组织(AT)血液和淋巴微血管密度和超微结构之间的关系。材料与方法:我们观察了125例患者，其中肥胖患者82例，瘦弱非糖尿病患者30例。采用Multiplex分析法测定空腹血清中瘦素、抵抗素、脂肪素、脂联素的浓度。DEXA法测定脂肪量和AT分布。对25例患者和15例健康人进行了腹部皮下AT的刀活检。应用CD-34、podoplanin和LYVE-1生物标志物免疫组化鉴定血液和淋巴微血管。结果:与对照组相比，糖尿病患者的瘦素(p=0.004)、抵抗素(p<0.0001)、脂肪素(p<0.0001)和脂肪素(p=0.0003)水平显著升高。瘦素、抵抗素和脂肪素的浓度与总脂肪量有关。抵抗素和脂联素水平与躯干和腹部中央脂肪量有关。2型糖尿病和肥胖患者瘦素水平的升高与皮下脂肪中血液和淋巴微血管的体积和数量密度的减少有关(r=-0.63, p=0.02;r = -0.55, p = 0.05)。抵抗素水平与淋巴管数量密度呈负相关(r=-0.59, p=0.03)。结论:2型糖尿病患者循环脂肪因子水平与体脂分布和AT微血管密度有不同的相关性。
{"title":"Serum Levels of Adipokines in Type 2 Diabetic Subjects: the Relationships with Adipose Tissue Distribution and Microvasculature","authors":"D. Bulumbaeva, V. Klimontov, N. Bgatova, Y. Taskaeva, O. Fazullina, N. B. Orlov, V. Konenkov, M. Soluyanov, S. Savchenko","doi":"10.1109/CSGB.2018.8544862","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544862","url":null,"abstract":"The aim: to determine the relationships between serum levels of adipokines, body fat distribution, and the density and ultrastructure of blood and lymphatic microvessels in subcutaneous adipose tissue (AT) in type 2 diabetic subjects. Materials and Methods: We observed 125 patients, including 82 ones with obesity, and 30 lean non-diabetic individuals. The concentrations of leptin, resistin, visfatin, adipsin, and adiponectin in the fasting serum were determined by Multiplex analysis. The fat mass and AT distribution was assessed by DEXA. The samples of subcutaneous abdominal AT were obtained with the knife biopsy in 25 patients and in 15 healthy subjects. Immunohistochemistry for biomarkers CD-34, podoplanin and LYVE-1 was applied to identify the blood and lymphatic microvessels. Results: Patients with diabetes, as compared to control, had significantly higher levels of leptin (p=0.004), resistin (p<0.0001), adipsin (p<0.0001) and visfatin (p=0.0003). The concentrations of leptin, resistin and adipsin were associated with total fat mass. The levels of resistin and adiponectin demonstrated relationships with truncal and central abdominal fat mass. The increase in leptin levels in patients with type 2 diabetes and obesity was associated with a decrease in the volume and numeral density of the blood and lymph microvessels in the subcutaneous fat (r=-0.63, p=0.02; r=-0.55, p=0.05). The level of resistin was negatively correlated with the numeral density of lymphatic vessels (r=-0.59, p=0.03). Conclusion: The levels of circulating adipokines in patients with type 2 diabetes are related differently with body fat distribution and AT microvessel density.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115824842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544874
E. Privodnova
Cognitive training and rich environment are thought to contribute to high creativity in the elderly. Yet, the neural mechanisms underlying association between cognitive training and creativity is poorly understood. It has been reasoned that in young adults right cortex is more engaged in creative ideation. At the same time, right hemisphere is shown to be more affected by aging than left one. There are some reasons, that mental stimulation is effective in maintaining of functional productivity of the aging left hemisphere. We tested if index of EEG alpha asymmetry during divergent thinking and lateral characteristics of verbal memory may be considered as indicator of creative productivity in the elderly. 84 elderly mentally healthy adults participated in the study (43 were engaged in professional scientific activity). Laterality of verbal memory was assessed by dichotic test. EEG data were recorded while subjects were engaged in verbal divergent thinking test. ANOVA, regression and correlation analysis were used. Interhemispheric asymmetry in task-related alpha desynchronization with larger values in the right hemisphere was associated with the strength of right hemispheric strategies of verbal memory. This effect was related to low creative originality in elderly engaged in professional scientific activity. The results suggest that life-long mental stimulation could be responsible for additional involvement of the left-hemispheric strategies to enhance creative efficiency in the elderly. The study showed that the combination of psychometric and EEG methods of interhemispheric asymmetry assessment is a functional approach for objective investigation of creative capacity of the aging brain.
{"title":"EEG Alpha Asymmetry and Lateral Characteristics of Verbal Memory as a Useful Tool to Investigate Creative Capacity of the Aging Brain","authors":"E. Privodnova","doi":"10.1109/CSGB.2018.8544874","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544874","url":null,"abstract":"Cognitive training and rich environment are thought to contribute to high creativity in the elderly. Yet, the neural mechanisms underlying association between cognitive training and creativity is poorly understood. It has been reasoned that in young adults right cortex is more engaged in creative ideation. At the same time, right hemisphere is shown to be more affected by aging than left one. There are some reasons, that mental stimulation is effective in maintaining of functional productivity of the aging left hemisphere. We tested if index of EEG alpha asymmetry during divergent thinking and lateral characteristics of verbal memory may be considered as indicator of creative productivity in the elderly. 84 elderly mentally healthy adults participated in the study (43 were engaged in professional scientific activity). Laterality of verbal memory was assessed by dichotic test. EEG data were recorded while subjects were engaged in verbal divergent thinking test. ANOVA, regression and correlation analysis were used. Interhemispheric asymmetry in task-related alpha desynchronization with larger values in the right hemisphere was associated with the strength of right hemispheric strategies of verbal memory. This effect was related to low creative originality in elderly engaged in professional scientific activity. The results suggest that life-long mental stimulation could be responsible for additional involvement of the left-hemispheric strategies to enhance creative efficiency in the elderly. The study showed that the combination of psychometric and EEG methods of interhemispheric asymmetry assessment is a functional approach for objective investigation of creative capacity of the aging brain.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133938632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544827
A. Kotlyarova, A. Letyagin, T. Tolstikova, L. N. Rachkovskaya, T. Popova
This study assessed the comparative pharmacokinetics of a novel prolonged release dosage form of lithium citrate in white outbred mature mice – males after single intragastrically administration. In the experiment mice were divided into two groups (8-10 animals each group) which were received lithium citrate (LC) (75 mg/kg) or complex based on lithium citrate, aluminum oxide and organosilicone polymer (LCAS) (1120 mg/kg) once intragastrically. These doses were calculated based on lithium containing at the ratio 5,6 mg/kg. Pharmacokinetic parameters and relative bioavailability were calculated based on lithium ions concentration in serum and brain, which was measured by inductively-coupled plasma atomic emission spectrometry (ICP-AES). According to received pharmacological data of LCAS the Cmax of lithium ions in serum is lower by 4,3 times, than if administration of LC, relative bioavailability of LCAS is 44.41% of standard LC. Performed research has proven that combining aluminium oxide and organosilicone polymer as supportive components with lithium citrate helps to maintaining a stable lithium ions concentration in blood and brain which is important for achieving positive lithium therapy effect.
{"title":"Comparative Pharmacokinetic Analysis of а Novel Prolonged Release Dosage Form of Lithium Citrate in Mice","authors":"A. Kotlyarova, A. Letyagin, T. Tolstikova, L. N. Rachkovskaya, T. Popova","doi":"10.1109/CSGB.2018.8544827","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544827","url":null,"abstract":"This study assessed the comparative pharmacokinetics of a novel prolonged release dosage form of lithium citrate in white outbred mature mice – males after single intragastrically administration. In the experiment mice were divided into two groups (8-10 animals each group) which were received lithium citrate (LC) (75 mg/kg) or complex based on lithium citrate, aluminum oxide and organosilicone polymer (LCAS) (1120 mg/kg) once intragastrically. These doses were calculated based on lithium containing at the ratio 5,6 mg/kg. Pharmacokinetic parameters and relative bioavailability were calculated based on lithium ions concentration in serum and brain, which was measured by inductively-coupled plasma atomic emission spectrometry (ICP-AES). According to received pharmacological data of LCAS the Cmax of lithium ions in serum is lower by 4,3 times, than if administration of LC, relative bioavailability of LCAS is 44.41% of standard LC. Performed research has proven that combining aluminium oxide and organosilicone polymer as supportive components with lithium citrate helps to maintaining a stable lithium ions concentration in blood and brain which is important for achieving positive lithium therapy effect.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114744344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544878
N. Myakina, Igor A. Lots, V. Klimontov
The aim: to compare glucose variability (GV) parameters derived from continuous glucose monitoring (CGM) in daytime and nocturnal hours in insulin-treated subjects with type 1 and type 2 diabetes.Materials and Methods: The CGM data from 130 type 1 diabetic and 117 type 2 diabetic patients were analyzed. The original software Sakharok was applied for time in range analysis. The GV parameters: Mean Amplitude of Glucose Excursions (MAGE), Lability Index (LI), Low Blood Glucose Index (LBGI), High Blood Glucose Index (HBGI), Continuous Overlapping Net Glycemic Action (CONGA), and Mean Absolute Glucose (MAG) were calculated with EasyGV software.Results: Patients with type 1 diabetes, as compared to those with type 2 diabetes, had higher mean 24-hour GV parameters: MAGE (p=0.000002), LI (p<0.00001), LBGI (p<0.00001), HBGI (p=0.008) and MAG (p=0.0002). Nocturnal MAGE, LI, MAG, HBGI, CONGA and time in hyperglycemic range were also higher in patients with type 1 diabetes (all p<0.02). Nocturnal LBGI and the prevalence of hypoglycemia were similar in both groups. In day-time hours type 1 diabetic subjects, as compare to those with type 2 diabetes, demonstrate lower CONGA (p=0.04) and higher prevalence of hypoglycemic episodes (p=0.000004).Conclusion: Insulin-treated patients with type 1 diabetes, as compared to type 2 diabetic subjects, have greater 24- hour CGM-derived GV parameters with more pronounced glucose fluctuations in the hyperglycemic range at night and more prevalent episodes of hypoglycemia in the daytime.
{"title":"Continuous Glucose Monitoring Data Analysis in Insulin-Treated Type 1 And Type 2 Diabetic Subjects with the Use of Original Software","authors":"N. Myakina, Igor A. Lots, V. Klimontov","doi":"10.1109/CSGB.2018.8544878","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544878","url":null,"abstract":"The aim: to compare glucose variability (GV) parameters derived from continuous glucose monitoring (CGM) in daytime and nocturnal hours in insulin-treated subjects with type 1 and type 2 diabetes.Materials and Methods: The CGM data from 130 type 1 diabetic and 117 type 2 diabetic patients were analyzed. The original software Sakharok was applied for time in range analysis. The GV parameters: Mean Amplitude of Glucose Excursions (MAGE), Lability Index (LI), Low Blood Glucose Index (LBGI), High Blood Glucose Index (HBGI), Continuous Overlapping Net Glycemic Action (CONGA), and Mean Absolute Glucose (MAG) were calculated with EasyGV software.Results: Patients with type 1 diabetes, as compared to those with type 2 diabetes, had higher mean 24-hour GV parameters: MAGE (p=0.000002), LI (p<0.00001), LBGI (p<0.00001), HBGI (p=0.008) and MAG (p=0.0002). Nocturnal MAGE, LI, MAG, HBGI, CONGA and time in hyperglycemic range were also higher in patients with type 1 diabetes (all p<0.02). Nocturnal LBGI and the prevalence of hypoglycemia were similar in both groups. In day-time hours type 1 diabetic subjects, as compare to those with type 2 diabetes, demonstrate lower CONGA (p=0.04) and higher prevalence of hypoglycemic episodes (p=0.000004).Conclusion: Insulin-treated patients with type 1 diabetes, as compared to type 2 diabetic subjects, have greater 24- hour CGM-derived GV parameters with more pronounced glucose fluctuations in the hyperglycemic range at night and more prevalent episodes of hypoglycemia in the daytime.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121654672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/csgb.2018.8544899
{"title":"BGRSSB 2018 Acknowledgement of Support","authors":"","doi":"10.1109/csgb.2018.8544899","DOIUrl":"https://doi.org/10.1109/csgb.2018.8544899","url":null,"abstract":"","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"21 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114102949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544805
N. Myakina, Alla K. Vigel, Igor A. Lots
The aim: to assess the relationships between glucose variability (GV) parameters and renal function in patients with type 1 diabetes (T1D) at different stages of chronic kidney disease (CKD). Materials and Methods: We observed 127 patients with T1D, 48 M/79 F, from 18 to 72 years of age. Patients were divided into 5 groups: 1) no signs of CKD (CKD0), n=27; 2) CKD С1-C2, n=67; 3) CKD С3-C4, n=26; 5) CKD С5 (hemodialysis, n=7). Time in ranges and GV parameters: Mean Amplitude of Glucose Excursions (MAGE), Lability Index (LI), Low Blood Glucose Index (LBGI), High Blood Glucose Index (HBGI), 2-hour Continuous Overlapping Net Glycemic Action (CONGA), and Mean Absolute Glucose (MAG) were derived from 72-hour continuous glucose monitoring. Results: As compared to patients without CKD, the values of MAGE, LI, HBGI were increased significantly in patients with CKD C1-C2 (all p<0.05). No differences were found in all GV parameters between CKD C3-C4 and CKD0 groups. In patients on hemodialysis time in hyperglycemic range, MAGE, LI, CONGA and HBGI were significantly higher as compared to other groups (all p<0.05). In patients with CKD C3-C5 there were negative correlations between HBGI, CONGA and estimated glomerular filtration rate (eGFR). In patients with eGFR >60 ml/min/1.73m2 HbA1c levels correlated positively with mean monitored glucose, time in hyperglycemic range, HBGI, CONGA, MAGE, LI, and MAG. On the contrary, in patients with lower eGFR none of GV parameters correlated with HbA1c. Conclusions: The results demonstrate non-linear relationships between eGFR and GV parameters in patients with T1D.
{"title":"Time in Range Analysis and Glucose Variability in Type 1 Diabetic Patients with Different Stages of Chronic Kidney Disease","authors":"N. Myakina, Alla K. Vigel, Igor A. Lots","doi":"10.1109/CSGB.2018.8544805","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544805","url":null,"abstract":"The aim: to assess the relationships between glucose variability (GV) parameters and renal function in patients with type 1 diabetes (T1D) at different stages of chronic kidney disease (CKD). Materials and Methods: We observed 127 patients with T1D, 48 M/79 F, from 18 to 72 years of age. Patients were divided into 5 groups: 1) no signs of CKD (CKD0), n=27; 2) CKD С1-C2, n=67; 3) CKD С3-C4, n=26; 5) CKD С5 (hemodialysis, n=7). Time in ranges and GV parameters: Mean Amplitude of Glucose Excursions (MAGE), Lability Index (LI), Low Blood Glucose Index (LBGI), High Blood Glucose Index (HBGI), 2-hour Continuous Overlapping Net Glycemic Action (CONGA), and Mean Absolute Glucose (MAG) were derived from 72-hour continuous glucose monitoring. Results: As compared to patients without CKD, the values of MAGE, LI, HBGI were increased significantly in patients with CKD C1-C2 (all p<0.05). No differences were found in all GV parameters between CKD C3-C4 and CKD0 groups. In patients on hemodialysis time in hyperglycemic range, MAGE, LI, CONGA and HBGI were significantly higher as compared to other groups (all p<0.05). In patients with CKD C3-C5 there were negative correlations between HBGI, CONGA and estimated glomerular filtration rate (eGFR). In patients with eGFR >60 ml/min/1.73m2 HbA1c levels correlated positively with mean monitored glucose, time in hyperglycemic range, HBGI, CONGA, MAGE, LI, and MAG. On the contrary, in patients with lower eGFR none of GV parameters correlated with HbA1c. Conclusions: The results demonstrate non-linear relationships between eGFR and GV parameters in patients with T1D.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127967849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.1109/CSGB.2018.8544728
V. Klimontov, E. Koroleva, O. Fazullina
We aimed to assess the effect of transition to Gla-300 from other basal insulin analogues on glucose variability (GV) parameters in hospitalized patients with type 1 diabetes. Materials and Methods: Twenty six diabetic subjects, 10 M/16 F, from 19 to 67 years of age (median – 44 years), HbA1c from 6.9 to 13.2% (median –9.4%), were switched to Gla-300 from other basal analogues: Gla-100 (n=15), detemir (n=10), and degludec (n=1). Dose titration of Gla-300 was performed in accordance with current recommendations. The GV parameters: High Blood Glucose Index (HBGI), Low Blood Glucose Index (LBGI), Mean Amplitude of Glucose Excursions (MAGE), and Lability Index (LI) were derived from two 3-day 6-point glucose profiles. Results: At 6-12 day after transition to Gla-300 mean fasting and postprandial glucose decreased significantly (10.3, 8.1-12.2 vs. 7.8, 6.7-8.8 mmol/l, p=0.008 and 10.5, 7.9-14.2 vs. 7.9, 6.7-9.6 mmol/l, p=0.02 resp.). There was decrease in the values of HBGI (11.2, 6.3-18 vs. 6.9, 3.6-12.1, p=0.01) and LI (3.4, 2.1-6.1 vs. 2.2, 1.6-3.5, p=0.04), without significant LBGI increment (1.6, 0.5-4.0 vs. 2.7, 0.7-5.0 (mmol/l)2/h, р=0.16) and MAGE changes (5.7, 3.6-6.8 vs. 4.4, 3.3-6.0 mmol/l, p=0.32). The mean dose of basal insulin did not change significantly (25.5, 19-32 vs. 27, 18-38 U/day, p=0.97). Conclusion: Switching to insulin Gla-300 from other basal insulin analogues provided less 24-hour GV in hospitalized patients with type 1 diabetes.
我们的目的是评估从其他基础胰岛素类似物过渡到Gla-300对住院1型糖尿病患者葡萄糖变异性(GV)参数的影响。材料和方法:26名糖尿病患者，10名M/16名F，年龄从19岁到67岁(中位- 44岁)，HbA1c从6.9到13.2%(中位- 9.4%)，从其他基础类似物:Gla-100 (n=15)， detemir (n=10)和degludec (n=1)切换到Gla-300。按照目前的建议进行Gla-300的剂量滴定。GV参数:高血糖指数(HBGI)、低血糖指数(LBGI)、平均血糖漂移幅度(MAGE)和不稳定性指数(LI)由2个3天的6点血糖谱得出。结果:转换到Gla-300后6-12天，平均空腹和餐后血糖显著降低(10.3,8.1-12.2 vs. 7.8, 6.7-8.8 mmol/l, p=0.008; 10.5, 7.9-14.2 vs. 7.9, 6.7-9.6 mmol/l, p=0.02)。HBGI值(11.2、6.3 ~ 18 vs. 6.9、3.6 ~ 12.1,p=0.01)和LI值(3.4、2.1 ~ 6.1 vs. 2.2、1.6 ~ 3.5,p=0.04)下降，LBGI值(1.6、0.5 ~ 4.0 vs. 2.7、0.7 ~ 5.0 (mmol/l)2/h, p= 0.16)和MAGE值(5.7、3.6 ~ 6.8 vs. 4.4、3.3 ~ 6.0 mmol/l, p=0.32)变化不显著。基础胰岛素的平均剂量无显著变化(25.5,19-32比27,18-38 U/天，p=0.97)。结论:从其他基础胰岛素类似物转向胰岛素Gla-300可降低住院1型糖尿病患者24小时GV。
{"title":"Switching to insulin glargine 300 U/mL from other basal insulin analogues provides less 24-hour glucose variability in hospitalized patients with type 1 diabetes","authors":"V. Klimontov, E. Koroleva, O. Fazullina","doi":"10.1109/CSGB.2018.8544728","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544728","url":null,"abstract":"We aimed to assess the effect of transition to Gla-300 from other basal insulin analogues on glucose variability (GV) parameters in hospitalized patients with type 1 diabetes. Materials and Methods: Twenty six diabetic subjects, 10 M/16 F, from 19 to 67 years of age (median – 44 years), HbA1c from 6.9 to 13.2% (median –9.4%), were switched to Gla-300 from other basal analogues: Gla-100 (n=15), detemir (n=10), and degludec (n=1). Dose titration of Gla-300 was performed in accordance with current recommendations. The GV parameters: High Blood Glucose Index (HBGI), Low Blood Glucose Index (LBGI), Mean Amplitude of Glucose Excursions (MAGE), and Lability Index (LI) were derived from two 3-day 6-point glucose profiles. Results: At 6-12 day after transition to Gla-300 mean fasting and postprandial glucose decreased significantly (10.3, 8.1-12.2 vs. 7.8, 6.7-8.8 mmol/l, p=0.008 and 10.5, 7.9-14.2 vs. 7.9, 6.7-9.6 mmol/l, p=0.02 resp.). There was decrease in the values of HBGI (11.2, 6.3-18 vs. 6.9, 3.6-12.1, p=0.01) and LI (3.4, 2.1-6.1 vs. 2.2, 1.6-3.5, p=0.04), without significant LBGI increment (1.6, 0.5-4.0 vs. 2.7, 0.7-5.0 (mmol/l)2/h, р=0.16) and MAGE changes (5.7, 3.6-6.8 vs. 4.4, 3.3-6.0 mmol/l, p=0.32). The mean dose of basal insulin did not change significantly (25.5, 19-32 vs. 27, 18-38 U/day, p=0.97). Conclusion: Switching to insulin Gla-300 from other basal insulin analogues provided less 24-hour GV in hospitalized patients with type 1 diabetes.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125134247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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