首页 > 最新文献

Therapeutic Advances in Ophthalmology最新文献

英文 中文
Effect of pattern scanning laser on macular thickness in diabetic retinopathy. 激光模式扫描对糖尿病视网膜病变黄斑厚度的影响。
IF 2.5 Q2 OPHTHALMOLOGY Pub Date : 2021-08-12 eCollection Date: 2021-01-01 DOI: 10.1177/25158414211035860
Nadine Hamed, Logan Vander Woude, Ramak Roohipourmoallai, Collin Ohning, Kathleen A Regan, Siva S R Iyer

Purpose: This study investigates the effect of pattern scanning laser (PASCAL) panretinal photocoagulation (PRP) on central macular thickness (CMT) and visual acuity (VA) in patients with proliferative diabetic retinopathy (PDR).

Methods: This retrospective non-randomized comparative case series included 262 eyes (163 with macular edema) of 177 patients with PDR. Treatment was PRP alone (137), PRP + anti-vascular endothelial growth factor (VEGF) (69), PRP + focal laser (28), or all three (89). CMT and central macular volume 3 and 6 mm from fovea were analyzed before and 1, 3, and 6 months after PRP. Spot number was plotted against CMT, and linear regression analysis was performed.

Results: For each treatment group and time point, there was a non-significant relationship between spot number and CMT. In eyes receiving all three treatment modalities, a significant negative relationship was found between spot number and 3-mm volume at 6 months (p = 0.04) and 6-mm volume at 1 month (p = 0.002) and 6 months (p = 0.011). There was no significant change in VA in any treatment group at the 6-month time point.

Conclusion: PASCAL PRP ± focal laser or anti-VEGF was not associated with increased development of macular edema or change in VA. PASCAL PRP with focal laser and anti-VEGF may result in a decrease in macular edema.

目的:探讨模式扫描激光(PASCAL)全视网膜光凝治疗(PRP)对增殖性糖尿病视网膜病变(PDR)患者中央黄斑厚度(CMT)和视力(VA)的影响。方法:对177例PDR患者262只眼(163只伴黄斑水肿)进行回顾性非随机对照研究。治疗方法为单独PRP(137人)、PRP +抗血管内皮生长因子(VEGF)(69人)、PRP +聚焦激光(28人)或三者同时治疗(89人)。在PRP前、PRP后1、3、6个月分别分析CMT和距中央凹3、6 mm的黄斑中央体积。用CMT绘制斑点数,进行线性回归分析。结果:在各治疗组和时间点,斑数与CMT无显著相关。在接受三种治疗方式的眼睛中,斑数与6个月时的3-mm体积(p = 0.04)、1个月时的6-mm体积(p = 0.002)和6个月时的6-mm体积(p = 0.011)呈显著负相关。在6个月的时间点上,任何治疗组的VA均无显著变化。结论:PASCAL PRP±局灶激光或抗vegf与黄斑水肿的加重和VA的改变无关,PASCAL PRP联合局灶激光和抗vegf可减轻黄斑水肿。
{"title":"Effect of pattern scanning laser on macular thickness in diabetic retinopathy.","authors":"Nadine Hamed,&nbsp;Logan Vander Woude,&nbsp;Ramak Roohipourmoallai,&nbsp;Collin Ohning,&nbsp;Kathleen A Regan,&nbsp;Siva S R Iyer","doi":"10.1177/25158414211035860","DOIUrl":"https://doi.org/10.1177/25158414211035860","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates the effect of pattern scanning laser (PASCAL) panretinal photocoagulation (PRP) on central macular thickness (CMT) and visual acuity (VA) in patients with proliferative diabetic retinopathy (PDR).</p><p><strong>Methods: </strong>This retrospective non-randomized comparative case series included 262 eyes (163 with macular edema) of 177 patients with PDR. Treatment was PRP alone (137), PRP + anti-vascular endothelial growth factor (VEGF) (69), PRP + focal laser (28), or all three (89). CMT and central macular volume 3 and 6 mm from fovea were analyzed before and 1, 3, and 6 months after PRP. Spot number was plotted against CMT, and linear regression analysis was performed.</p><p><strong>Results: </strong>For each treatment group and time point, there was a non-significant relationship between spot number and CMT. In eyes receiving all three treatment modalities, a significant negative relationship was found between spot number and 3-mm volume at 6 months (<i>p</i> = 0.04) and 6-mm volume at 1 month (<i>p</i> = 0.002) and 6 months (<i>p</i> = 0.011). There was no significant change in VA in any treatment group at the 6-month time point.</p><p><strong>Conclusion: </strong>PASCAL PRP ± focal laser or anti-VEGF was not associated with increased development of macular edema or change in VA. PASCAL PRP with focal laser and anti-VEGF may result in a decrease in macular edema.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211035860"},"PeriodicalIF":2.5,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/83/10.1177_25158414211035860.PMC8366200.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39324303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The change of anterior chamber angle parameters after cataract surgery in diabetic patients. 糖尿病患者白内障术后前房角参数的变化。
IF 2.5 Q2 OPHTHALMOLOGY Pub Date : 2021-08-10 eCollection Date: 2021-01-01 DOI: 10.1177/25158414211034717
Alper Halil Bayat, Cetin Akpolat

Purpose: The purpose of this study is to investigate the change of anterior chamber angle morphology after cataract surgery in patients with type 2 diabetes mellitus (DM2) using anterior segment optical coherence tomography (AS-OCT).

Methods: In this prospective and comparative study, 57 eyes of the patients with cataract were investigated. The patients were divided into two groups. The DM2 group included cataractous type 2 diabetic patients without diabetic retinopathy (n = 30) and the non-DM2 group included nondiabetic participants with cataract (n = 27). The AS-OCT examinations were performed at baseline and 1 month after the cataract surgery. The corrected distance visual acuity (CDVA), intraocular pressure (IOP), angle-opening distance at 500 µm (AOD-500) and trabecular iris space area at 500 µm (TISA-500), and scleral spur angle (SSA) in temporal quadrant were analyzed.

Results: The mean age, sex, and axial length values were similar in both groups (p > 0.05 for all). The CDVA was significantly improved in both groups (p < 0.001). The mean AOD-500, TISA-500, and SSA were increased and the mean IOP was decreased after cataract surgery in both groups (p < 0.001 for all). There were not any statistically significant intergroup differences in CDVA, IOP, and AS-OCT measurements between the DM2 and non-DM2 groups (p > 0.05 for all).

Conclusion: Cataract surgery showed significant increases in mean anterior chamber angle parameters and reductions in IOP values in both diabetic and nondiabetic patients without intergroup significant differences. These results suggested the safety and effectiveness of cataract surgery, especially regarding anterior chamber angle parameters and so IOP changes.

目的:利用光学相干断层扫描(AS-OCT)研究2型糖尿病(DM2)白内障手术后前房角形态的变化。方法:对57眼白内障患者进行前瞻性对比研究。患者被分为两组。DM2组包括无糖尿病视网膜病变的白内障2型糖尿病患者(n = 30),非DM2组包括有白内障的非糖尿病患者(n = 27)。在基线和白内障手术后1个月进行AS-OCT检查。分析矫正距离视力(CDVA)、眼内压(IOP)、500µm开角距离(AOD-500)、500µm虹膜小梁间隙面积(TISA-500)、颞象限巩膜骨刺角(SSA)。结果:两组患者的平均年龄、性别和轴长值相似(p > 0.05)。两组CDVA均显著改善(p < 0.05)。结论:白内障手术后糖尿病患者和非糖尿病患者的平均前房角参数升高,IOP值降低,组间差异无统计学意义。这些结果提示白内障手术的安全性和有效性,特别是前房角参数和IOP的变化。
{"title":"The change of anterior chamber angle parameters after cataract surgery in diabetic patients.","authors":"Alper Halil Bayat,&nbsp;Cetin Akpolat","doi":"10.1177/25158414211034717","DOIUrl":"https://doi.org/10.1177/25158414211034717","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to investigate the change of anterior chamber angle morphology after cataract surgery in patients with type 2 diabetes mellitus (DM2) using anterior segment optical coherence tomography (AS-OCT).</p><p><strong>Methods: </strong>In this prospective and comparative study, 57 eyes of the patients with cataract were investigated. The patients were divided into two groups. The DM2 group included cataractous type 2 diabetic patients without diabetic retinopathy (<i>n</i> = 30) and the non-DM2 group included nondiabetic participants with cataract (<i>n</i> = 27). The AS-OCT examinations were performed at baseline and 1 month after the cataract surgery. The corrected distance visual acuity (CDVA), intraocular pressure (IOP), angle-opening distance at 500 µm (AOD-500) and trabecular iris space area at 500 µm (TISA-500), and scleral spur angle (SSA) in temporal quadrant were analyzed.</p><p><strong>Results: </strong>The mean age, sex, and axial length values were similar in both groups (<i>p</i> > 0.05 for all). The CDVA was significantly improved in both groups (<i>p</i> < 0.001). The mean AOD-500, TISA-500, and SSA were increased and the mean IOP was decreased after cataract surgery in both groups (<i>p</i> < 0.001 for all). There were not any statistically significant intergroup differences in CDVA, IOP, and AS-OCT measurements between the DM2 and non-DM2 groups (<i>p</i> > 0.05 for all).</p><p><strong>Conclusion: </strong>Cataract surgery showed significant increases in mean anterior chamber angle parameters and reductions in IOP values in both diabetic and nondiabetic patients without intergroup significant differences. These results suggested the safety and effectiveness of cataract surgery, especially regarding anterior chamber angle parameters and so IOP changes.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211034717"},"PeriodicalIF":2.5,"publicationDate":"2021-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/80/cd/10.1177_25158414211034717.PMC8365015.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39326764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An overview of psychological and social factors in Charles Bonnet syndrome. 邦纳综合症的心理和社会因素综述。
IF 2.5 Q2 OPHTHALMOLOGY Pub Date : 2021-07-30 eCollection Date: 2021-01-01 DOI: 10.1177/25158414211034715
Lee Jones, Lara Ditzel-Finn, Jamie Enoch, Mariya Moosajee

Charles Bonnet syndrome (CBS) is a condition where cognitively normal individuals with sight impairment experience simple and/or complex visual hallucinations. The exact pathogenesis of CBS is unknown; however, deafferentation is often recognised as a causal mechanism. Studies have provided insight into the multifaceted impact of CBS on wellbeing. Onset of CBS may cause distress among those believing visual hallucinations are indicative of a neurological condition. Hallucinatory content is often congruent with the emotional response. For example, hallucinations of a macabre nature typically result in a fearful response. Visual hallucinations may be highly disruptive, causing everyday tasks to become challenging. Clinical management relies on forewarning and pre-emptive questioning. Yet, knowledge and awareness of CBS is typically low. In this review, we provide a summary of the social and psychological implications of CBS and explore recent developments aimed at raising awareness and improving patient management.

查尔斯邦纳综合征(CBS)是一种认知正常的视力障碍患者出现简单和/或复杂视觉幻觉的情况。CBS的确切发病机制尚不清楚;然而,神经分化通常被认为是一种因果机制。研究揭示了CBS对幸福感的多方面影响。在那些认为视幻觉是神经系统疾病的患者中,CBS的发作可能会引起痛苦。幻觉的内容往往与情绪反应一致。例如,可怕的幻觉通常会导致可怕的反应。视觉幻觉可能是高度破坏性的,导致日常任务变得具有挑战性。临床管理依赖于预警和先发制人的询问。然而,对CBS的了解和意识通常很低。在这篇综述中,我们总结了CBS的社会和心理影响,并探讨了旨在提高认识和改善患者管理的最新进展。
{"title":"An overview of psychological and social factors in Charles Bonnet syndrome.","authors":"Lee Jones,&nbsp;Lara Ditzel-Finn,&nbsp;Jamie Enoch,&nbsp;Mariya Moosajee","doi":"10.1177/25158414211034715","DOIUrl":"https://doi.org/10.1177/25158414211034715","url":null,"abstract":"<p><p>Charles Bonnet syndrome (CBS) is a condition where cognitively normal individuals with sight impairment experience simple and/or complex visual hallucinations. The exact pathogenesis of CBS is unknown; however, deafferentation is often recognised as a causal mechanism. Studies have provided insight into the multifaceted impact of CBS on wellbeing. Onset of CBS may cause distress among those believing visual hallucinations are indicative of a neurological condition. Hallucinatory content is often congruent with the emotional response. For example, hallucinations of a macabre nature typically result in a fearful response. Visual hallucinations may be highly disruptive, causing everyday tasks to become challenging. Clinical management relies on forewarning and pre-emptive questioning. Yet, knowledge and awareness of CBS is typically low. In this review, we provide a summary of the social and psychological implications of CBS and explore recent developments aimed at raising awareness and improving patient management.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211034715"},"PeriodicalIF":2.5,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/25158414211034715","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39300387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Pediatric uveitis: a retrospective analysis at a tertiary eye care hospital in South India. 小儿葡萄膜炎:南印度一家三级眼科医院的回顾性分析。
IF 2.3 Q2 OPHTHALMOLOGY Pub Date : 2021-07-30 eCollection Date: 2021-01-01 DOI: 10.1177/25158414211027707
Sowmya Raveendra Murthy, Sailatha Ganesh, Minija C K, Nidhi Dubey

Purpose: To analyze the demographics, etiology, complications, treatment modalities, and visual outcomes in pediatric uveitis patients at a tertiary eye care hospital.

Methods: A retrospective review of medical records of pediatric uveitis patients who presented with us from January 2014 to January 2020 was evaluated.

Results: Out of the 178 pediatric uveitis patients, 65 children were included in the study. The most common age group was 6-10 years (46%). Of the included patients, 36 (55.4%) were male and 29 (44.6%) were female. Presentation was bilateral in 39 (60%) and unilateral in 26 (40%). Anterior uveitis was seen in 19 (29.23%), intermediate in 18 (27.69%), posterior in 16 (24.62%), and panuveitis in 12 (18.46%) patients. There were 2 cases of masquerades. Non-infectious uveitis was the most commonly seen, in 48 (73.84%) of total cases, among which 21 (43.75%) were idiopathic and 7 (14.58%) were associated with juvenile idiopathic (JIA) arthritis. Infectious uveitis was present in 17 (26.15%); the most common etiology was toxoplasmosis. Baseline visual acuity was low in 22 (33.84%) children. After initiating treatment, 37 (56.92%) showed improvement in vision and 10 (15.38%) had worsening of vision. Intraocular pressure (IOP) rise was seen in 5 (7.69%) children; 51 (78.46%) children required medical management and 16 (24.61%) children required surgical intervention; 46 (70.76%) children had uveitis related complications out of which most of them 30 (65.21%) were present at baseline.

Conclusions: Anterior and intermediate uveitis were the most common types observed in our study. Toxoplasmosis was the most common type of infectious uveitis and JIA the most common cause in non-infectious type apart from idiopathic uveitis. Posterior uveitis had low visual acuity at baseline and follow-up. Children presented to us with poor visual acuity and complications at baseline, hence an early referral to a tertiary eye hospital and management accordingly can improve the quality of vision and visual rehabilitation.

目的:分析一家三级眼科医院小儿葡萄膜炎患者的人口统计学、病因学、并发症、治疗方式和视觉结果:方法:对2014年1月至2020年1月来我院就诊的小儿葡萄膜炎患者的病历进行回顾性分析:在178名小儿葡萄膜炎患者中,有65名儿童被纳入研究。最常见的年龄组为 6-10 岁(46%)。在纳入的患者中,36 名(55.4%)为男性,29 名(44.6%)为女性。39例(60%)为双侧发病,26例(40%)为单侧发病。前葡萄膜炎有 19 例(29.23%),中间型有 18 例(27.69%),后葡萄膜炎有 16 例(24.62%),泛葡萄膜炎有 12 例(18.46%)。其中 2 例为假性葡萄膜炎。非感染性葡萄膜炎最常见,占总病例的 48 例(73.84%),其中 21 例(43.75%)为特发性葡萄膜炎,7 例(14.58%)与幼年特发性(JIA)关节炎有关。17例(26.15%)患者患有感染性葡萄膜炎;最常见的病因是弓形虫病。22名儿童(33.84%)的基线视力较低。开始治疗后,37 名儿童(56.92%)的视力有所改善,10 名儿童(15.38%)的视力恶化。5名儿童(7.69%)出现眼压(IOP)升高;51名儿童(78.46%)需要药物治疗,16名儿童(24.61%)需要手术治疗;46名儿童(70.76%)出现葡萄膜炎相关并发症,其中30名儿童(65.21%)在基线时就已出现并发症:我们的研究发现,前葡萄膜炎和中间葡萄膜炎是最常见的葡萄膜炎类型。弓形虫病是最常见的感染性葡萄膜炎,JIA 是除特发性葡萄膜炎外最常见的非感染性葡萄膜炎病因。后葡萄膜炎在基线和随访时视力较低。因此,及早将患儿转诊至三级眼科医院并进行相应的治疗,可以提高视力质量并促进视力康复。
{"title":"Pediatric uveitis: a retrospective analysis at a tertiary eye care hospital in South India.","authors":"Sowmya Raveendra Murthy, Sailatha Ganesh, Minija C K, Nidhi Dubey","doi":"10.1177/25158414211027707","DOIUrl":"10.1177/25158414211027707","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the demographics, etiology, complications, treatment modalities, and visual outcomes in pediatric uveitis patients at a tertiary eye care hospital.</p><p><strong>Methods: </strong>A retrospective review of medical records of pediatric uveitis patients who presented with us from January 2014 to January 2020 was evaluated.</p><p><strong>Results: </strong>Out of the 178 pediatric uveitis patients, 65 children were included in the study. The most common age group was 6-10 years (46%). Of the included patients, 36 (55.4%) were male and 29 (44.6%) were female. Presentation was bilateral in 39 (60%) and unilateral in 26 (40%). Anterior uveitis was seen in 19 (29.23%), intermediate in 18 (27.69%), posterior in 16 (24.62%), and panuveitis in 12 (18.46%) patients. There were 2 cases of masquerades. Non-infectious uveitis was the most commonly seen, in 48 (73.84%) of total cases, among which 21 (43.75%) were idiopathic and 7 (14.58%) were associated with juvenile idiopathic (JIA) arthritis. Infectious uveitis was present in 17 (26.15%); the most common etiology was toxoplasmosis. Baseline visual acuity was low in 22 (33.84%) children. After initiating treatment, 37 (56.92%) showed improvement in vision and 10 (15.38%) had worsening of vision. Intraocular pressure (IOP) rise was seen in 5 (7.69%) children; 51 (78.46%) children required medical management and 16 (24.61%) children required surgical intervention; 46 (70.76%) children had uveitis related complications out of which most of them 30 (65.21%) were present at baseline.</p><p><strong>Conclusions: </strong>Anterior and intermediate uveitis were the most common types observed in our study. Toxoplasmosis was the most common type of infectious uveitis and JIA the most common cause in non-infectious type apart from idiopathic uveitis. Posterior uveitis had low visual acuity at baseline and follow-up. Children presented to us with poor visual acuity and complications at baseline, hence an early referral to a tertiary eye hospital and management accordingly can improve the quality of vision and visual rehabilitation.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211027707"},"PeriodicalIF":2.3,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9c/14/10.1177_25158414211027707.PMC8326997.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39300383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in the complex management of post-keratoplasty glaucoma. 角膜移植术后青光眼复杂治疗的挑战。
IF 2.5 Q2 OPHTHALMOLOGY Pub Date : 2021-07-20 eCollection Date: 2021-01-01 DOI: 10.1177/25158414211031397
Lisa-Marie Anders, Zisis Gatzioufas, Matthias C Grieshaber

Glaucoma is a serious complication after corneal transplantation and itself a common cause for graft failure and leading cause of vision loss post-keratoplasty due to corneal endothelial decompensation. Endothelial keratoplasty procedures like Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) may be superior to penetrating keratoplasty (PK) regarding the incidence of elevated intraocular pressure (IOP) and development of glaucoma. There are indications that regardless of the method of keratoplasty, some corneal diseases like pseudophakic bullous keratopathy, corneal perforation, and graft rejection have a higher risk for developing post-keratoplasty glaucoma than keratoconus and corneal dystrophies and likewise respond less to IOP lowering therapy. In this review, the pathophysiology of post-keratoplasty glaucoma, the diagnostic tools with focus on different devices, and their limitations with regard to measuring IOP and the treatment modalities are presented.

青光眼是角膜移植术后的严重并发症,也是角膜移植失败的常见原因,也是角膜内皮失代偿导致角膜移植术后视力丧失的主要原因。在眼压升高(IOP)的发生率和青光眼的发展方面,内皮角膜移植术如Descemet剥离自动内皮角膜移植术(DSAEK)和Descemet膜内皮角膜移植术(DMEK)可能优于穿透性角膜移植术(PK)。有迹象表明,无论采用何种方法进行角膜移植,一些角膜疾病如假性大疱性角膜病变、角膜穿孔和移植排斥反应发生角膜移植后青光眼的风险高于圆锥角膜和角膜营养不良,对降低IOP治疗的反应也较小。本文综述了角膜移植术后青光眼的病理生理学,不同设备的诊断工具,以及它们在测量IOP和治疗方法方面的局限性。
{"title":"Challenges in the complex management of post-keratoplasty glaucoma.","authors":"Lisa-Marie Anders,&nbsp;Zisis Gatzioufas,&nbsp;Matthias C Grieshaber","doi":"10.1177/25158414211031397","DOIUrl":"https://doi.org/10.1177/25158414211031397","url":null,"abstract":"<p><p>Glaucoma is a serious complication after corneal transplantation and itself a common cause for graft failure and leading cause of vision loss post-keratoplasty due to corneal endothelial decompensation. Endothelial keratoplasty procedures like Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) may be superior to penetrating keratoplasty (PK) regarding the incidence of elevated intraocular pressure (IOP) and development of glaucoma. There are indications that regardless of the method of keratoplasty, some corneal diseases like pseudophakic bullous keratopathy, corneal perforation, and graft rejection have a higher risk for developing post-keratoplasty glaucoma than keratoconus and corneal dystrophies and likewise respond less to IOP lowering therapy. In this review, the pathophysiology of post-keratoplasty glaucoma, the diagnostic tools with focus on different devices, and their limitations with regard to measuring IOP and the treatment modalities are presented.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211031397"},"PeriodicalIF":2.5,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/25158414211031397","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39277176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Clinical outcomes and safety of Diphoterine® irrigation for chemical eye injury: A single-centre experience in the United Kingdom. 双photerine®冲洗治疗化学性眼损伤的临床结果和安全性:英国的单中心经验。
IF 2.5 Q2 OPHTHALMOLOGY Pub Date : 2021-07-16 eCollection Date: 2021-01-01 DOI: 10.1177/25158414211030429
Muzammil Ahmad Nahaboo Solim, Teresa Maria Lupion-Duran, Romeela Rana-Rahman, Trushar Patel, Desiree Ah-Kine, Darren S J Ting

Purpose: Diphoterine® is an amphoteric irrigating solution armed with rapid pH-neutralising action. It serves as an effective first-aid treatment for managing chemical burns, including chemical eye injury (CEI). However, its use is not widely adopted in current clinical practice, primarily attributed to limited clinical evidence. This study aims to highlight the experience in using Diphoterine for managing CEI in a UK tertiary referral centre.

Methods: This retrospective case series included all patients who presented with CEI and treated with Diphoterine at the James Cook University Hospital, UK, between April 2018 and February 2020.

Results: Seven patients (10 eyes) were included; the mean age was 28.2 ± 17.0 years (ranged, 3-70 years) and 85.7% were male. All patients presented with an alkaline injury with a mean presenting pH of 8.7 ± 0.7 and a median (±interquartile range [IQR]) corrected-distance visual acuity (CDVA) of 0.10 ± 0.28 logMAR. Based on Roper-Hall classification, 90% and 10% of the eyes were of grade-I and -IV CEI, respectively. All eyes received normal saline/water as the first irrigation fluid and Diphoterine as second irrigation fluid. The mean pH improved slightly after first irrigation (8.4 ± 0.7; p = 0.13) and significantly after second irrigation (7.6 ± 0.4; p = 0.001). The volume of irrigation used was significantly less for Diphoterine (520 ± 193 mL) than for normal saline/water (2700 ± 2451 mL; p = 0.016). At final follow-up (median = 5 days), the median CDVA remained stable at 0.10 ± 0.28 logMAR (p = 0.60). One patient developed near-total limbal stem cell deficiency as a complication of grade-IV injury and was awaiting limbal stem cell transplantation at last follow-up.

Conclusion: This study represents the first case series in the United Kingdom, reporting the use of Diphoterine in managing CEI. The rapid pH-neutralising action of Diphoterine, with less volume required, makes it an ideal initial treatment for efficiently managing adult and paediatric patients with CEI in clinics.

目的:双photerine®是一种两性冲洗液,具有快速ph中和作用。它是处理化学烧伤,包括化学眼损伤(CEI)的有效急救治疗方法。然而,由于临床证据有限,它的使用在目前的临床实践中并未被广泛采用。本研究的目的是强调在使用双photerine管理CEI在英国三级转诊中心的经验。方法:本回顾性病例系列包括2018年4月至2020年2月期间在英国詹姆斯库克大学医院接受双photerine治疗的所有CEI患者。结果:纳入7例患者(10眼);平均年龄28.2±17.0岁,年龄范围3 ~ 70岁,男性占85.7%。所有患者均表现为碱性损伤,平均pH值为8.7±0.7,校正距离视力(CDVA)中位数(±四分位数范围[IQR])为0.10±0.28 logMAR。根据Roper-Hall分类,90%的眼睛为i级,10%的眼睛为-IV级。所有眼均以生理盐水/水作为第一冲洗液,双蝶呤作为第二冲洗液。第一次灌溉后平均pH值略有改善(8.4±0.7);P = 0.13),第二次灌洗后P = 7.6±0.4;p = 0.001)。二photerine的冲洗量(520±193 mL)明显少于生理盐水/水(2700±2451 mL);p = 0.016)。在最后随访(中位= 5天)时,中位CDVA保持稳定在0.10±0.28 logMAR (p = 0.60)。一名患者出现了几乎完全的角膜缘干细胞缺乏症,作为iv级损伤的并发症,在最后的随访中等待角膜缘干细胞移植。结论:本研究代表了英国第一个病例系列,报告了使用双photerine治疗CEI。双photerine的快速ph中和作用,所需体积较小,使其成为临床有效管理成人和儿科CEI患者的理想初始治疗方法。
{"title":"Clinical outcomes and safety of Diphoterine<sup>®</sup> irrigation for chemical eye injury: A single-centre experience in the United Kingdom.","authors":"Muzammil Ahmad Nahaboo Solim,&nbsp;Teresa Maria Lupion-Duran,&nbsp;Romeela Rana-Rahman,&nbsp;Trushar Patel,&nbsp;Desiree Ah-Kine,&nbsp;Darren S J Ting","doi":"10.1177/25158414211030429","DOIUrl":"https://doi.org/10.1177/25158414211030429","url":null,"abstract":"<p><strong>Purpose: </strong>Diphoterine<sup>®</sup> is an amphoteric irrigating solution armed with rapid pH-neutralising action. It serves as an effective first-aid treatment for managing chemical burns, including chemical eye injury (CEI). However, its use is not widely adopted in current clinical practice, primarily attributed to limited clinical evidence. This study aims to highlight the experience in using Diphoterine for managing CEI in a UK tertiary referral centre.</p><p><strong>Methods: </strong>This retrospective case series included all patients who presented with CEI and treated with Diphoterine at the James Cook University Hospital, UK, between April 2018 and February 2020.</p><p><strong>Results: </strong>Seven patients (10 eyes) were included; the mean age was 28.2 ± 17.0 years (ranged, 3-70 years) and 85.7% were male. All patients presented with an alkaline injury with a mean presenting pH of 8.7 ± 0.7 and a median (±interquartile range [IQR]) corrected-distance visual acuity (CDVA) of 0.10 ± 0.28 logMAR. Based on Roper-Hall classification, 90% and 10% of the eyes were of grade-I and -IV CEI, respectively. All eyes received normal saline/water as the first irrigation fluid and Diphoterine as second irrigation fluid. The mean pH improved slightly after first irrigation (8.4 ± 0.7; <i>p</i> = 0.13) and significantly after second irrigation (7.6 ± 0.4; <i>p</i> = 0.001). The volume of irrigation used was significantly less for Diphoterine (520 ± 193 mL) than for normal saline/water (2700 ± 2451 mL; <i>p</i> = 0.016). At final follow-up (median = 5 days), the median CDVA remained stable at 0.10 ± 0.28 logMAR (<i>p</i> = 0.60). One patient developed near-total limbal stem cell deficiency as a complication of grade-IV injury and was awaiting limbal stem cell transplantation at last follow-up.</p><p><strong>Conclusion: </strong>This study represents the first case series in the United Kingdom, reporting the use of Diphoterine in managing CEI. The rapid pH-neutralising action of Diphoterine, with less volume required, makes it an ideal initial treatment for efficiently managing adult and paediatric patients with CEI in clinics.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211030429"},"PeriodicalIF":2.5,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/25158414211030429","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39276786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Retinal vascular findings in patients with COVID-19. COVID-19患者的视网膜血管表现。
IF 2.5 Q2 OPHTHALMOLOGY Pub Date : 2021-07-13 eCollection Date: 2021-01-01 DOI: 10.1177/25158414211030419
Emre Aydemir, Alper Halil Bayat, Burak Ören, Halil Ibrahim Atesoglu, Yasin Şakir Göker, Kazım Çağlar Özçelik

Purpose: The purpose of this study was to compare the retinal vascular caliber of COVID-19 patients with that of healthy subjects.

Methods: This was a prospective case-control study. Forty-six patients who had COVID-19 were successfully treated, and 38 age- and gender-matched healthy subjects were enrolled in this study. Fundus photography was taken using fundus fluorescein angiography (FA; Visucam 500; Carl Zeiss Meditec, Jena, Germany). Retinal vascular caliber was analyzed with IVAN, a semi-automated retinal vascular analyzer (Nicole J. Ferrier, College of Engineering, Fundus Photography Reading Center, University of Wisconsin, Madison, WI, USA). Central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and artery-vein ratio (AVR) were compared between groups.

Results: The mean age was 37.8 ± 9.5 years in the COVID-19 group (n = 46) and 40 ± 8 years in the control group (n = 38) (p = 0.45). The mean CRAE was 181.56 ± 6.40 in the COVID-19 group and 171.29 ± 15.06 in the control group (p = 0.006). The mean CRVE was 226.34 ± 23.83 in the COVID-19 group and 210.94 ± 22.22 in the control group (p = 0.044). AVR was 0.81 ± 0.09 in the COVID-19 group and 0.82 ± 0.13 in the control group (p = 0.712).

Conclusion: Patients who had COVID-19 have vasodilation in the retinal vascular structure after recovery. As they may be at risk of retinal vascular disease, COVID-19 patients must be followed after recovery.

目的:本研究的目的是比较COVID-19患者与健康受试者的视网膜血管口径。方法:前瞻性病例-对照研究。46名COVID-19患者成功治疗,38名年龄和性别匹配的健康受试者参加了这项研究。眼底造影采用眼底荧光素血管造影(FA);Visucam 500;卡尔蔡司Meditec,耶拿,德国)。使用半自动视网膜血管分析仪IVAN (Nicole J. Ferrier,工程学院,眼底摄影阅读中心,University of Wisconsin, Madison, WI, USA)分析视网膜血管口径。比较两组视网膜中央动脉当量(CRAE)、视网膜中央静脉当量(CRVE)和动静脉比(AVR)。结果:新冠肺炎组患者平均年龄为37.8±9.5岁(n = 46),对照组平均年龄为40±8岁(n = 38) (p = 0.45)。新冠肺炎组平均CRAE为181.56±6.40,对照组为171.29±15.06 (p = 0.006)。新冠肺炎组平均CRVE为226.34±23.83,对照组为210.94±22.22 (p = 0.044)。新冠肺炎组AVR为0.81±0.09,对照组为0.82±0.13 (p = 0.712)。结论:COVID-19患者恢复后视网膜血管结构出现血管扩张。由于COVID-19患者可能存在视网膜血管疾病的风险,因此必须在康复后进行随访。
{"title":"Retinal vascular findings in patients with COVID-19.","authors":"Emre Aydemir,&nbsp;Alper Halil Bayat,&nbsp;Burak Ören,&nbsp;Halil Ibrahim Atesoglu,&nbsp;Yasin Şakir Göker,&nbsp;Kazım Çağlar Özçelik","doi":"10.1177/25158414211030419","DOIUrl":"https://doi.org/10.1177/25158414211030419","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to compare the retinal vascular caliber of COVID-19 patients with that of healthy subjects.</p><p><strong>Methods: </strong>This was a prospective case-control study. Forty-six patients who had COVID-19 were successfully treated, and 38 age- and gender-matched healthy subjects were enrolled in this study. Fundus photography was taken using fundus fluorescein angiography (FA; Visucam 500; Carl Zeiss Meditec, Jena, Germany). Retinal vascular caliber was analyzed with IVAN, a semi-automated retinal vascular analyzer (Nicole J. Ferrier, College of Engineering, Fundus Photography Reading Center, University of Wisconsin, Madison, WI, USA). Central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and artery-vein ratio (AVR) were compared between groups.</p><p><strong>Results: </strong>The mean age was 37.8 ± 9.5 years in the COVID-19 group (<i>n</i> = 46) and 40 ± 8 years in the control group (<i>n</i> = 38) (<i>p</i> = 0.45). The mean CRAE was 181.56 ± 6.40 in the COVID-19 group and 171.29 ± 15.06 in the control group (<i>p</i> = 0.006). The mean CRVE was 226.34 ± 23.83 in the COVID-19 group and 210.94 ± 22.22 in the control group (<i>p</i> = 0.044). AVR was 0.81 ± 0.09 in the COVID-19 group and 0.82 ± 0.13 in the control group (<i>p</i> = 0.712).</p><p><strong>Conclusion: </strong>Patients who had COVID-19 have vasodilation in the retinal vascular structure after recovery. As they may be at risk of retinal vascular disease, COVID-19 patients must be followed after recovery.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211030419"},"PeriodicalIF":2.5,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/25158414211030419","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39273669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Does pterygium morphology affect corneal astigmatism? 翼状胬肉形态会影响角膜散光吗?
IF 2.3 Q2 OPHTHALMOLOGY Pub Date : 2021-07-12 eCollection Date: 2021-01-01 DOI: 10.1177/25158414211030423
Emine Doğan, Burçin Çakır, Nilgün Aksoy, Elif Köse, Gürsoy Alagöz

Purpose: The purpose of this study was to evaluate the correlation between corneal astigmatism and the morphology of pterygium with anterior segment optic coherence tomography (AS-OCT).

Material and methods: The size of pterygium (horizontal length, vertical width) was measured manually; pterygium area and percentage extension of the pterygium onto the cornea were calculated. Anterior and posterior corneal astigmatism, Sim K, K1, K2 were measured using a dual Scheimpflug analyzer. Morphological patterns of the pterygium analyzed with AS-OCT were determined according to the extension of the pterygium apex below the corneal epithelium. Two tomographic patterns were identified: continuous and nodular. Correlation between anterior corneal astigmatism and pterygium size, percentage extension of the pterygium, and morphological pattern of the pterygium was analyzed.

Results: The mean ages of the 47 patients were 49.4 ± 16.6 (22-80) years. Mean horizontal pterygium length, vertical width, pterygium area, and percentage extension of the pterygium were 2.8 ± 1.2 mm, 4.8 ± 1.6 mm, 7.42 ± 5.6 mm2 and 24.5 ± 10.4%, respectively. Mean anterior corneal astigmatism was 2.3 ± 2.3 D and simulated keratometry was 43.4 ± 2.02 D. In terms of the morphological pattern of the pterygium, 24 eyes had continuous, 23 eyes had a nodular pattern and the median (interquartile range) anterior corneal astigmatism was 1.87 (1.01-3.80) and 1.22 D (0.58-2.35), respectively (p = 0.102). Other topographic and pterygium size parameters were similar between groups. Analyzing the correlations in groups separately, a positive moderate statistically significant correlation was present between vertical width, percentage extension, pterygium area, and anterior corneal astigmatism in both continuous and nodular groups.

Conclusions: Although not statistically significant, anterior corneal astigmatism was higher in continuous group. Using AS-OCT to standardize the morphology of pterygium could provide additional clinical information.

目的:本研究旨在通过前段光学相干断层扫描(AS-OCT)评估角膜散光与翼状胬肉形态之间的相关性:人工测量翼状胬肉的大小(水平长度和垂直宽度),计算翼状胬肉的面积和延伸至角膜的百分比。使用双 Scheimpflug 分析仪测量角膜前后散光、Sim K、K1、K2。用 AS-OCT 分析翼状胬肉的形态模式是根据胬肉顶点延伸到角膜上皮以下的程度确定的。确定了两种断层模式:连续型和结节型。分析了角膜前散光与翼状胬肉大小、翼状胬肉扩展百分比以及翼状胬肉形态模式之间的相关性:47名患者的平均年龄为(49.4 ± 16.6)(22-80)岁。平均翼状胬肉水平长度、垂直宽度、翼状胬肉面积和翼状胬肉扩展百分比分别为(2.8±1.2)毫米、(4.8±1.6)毫米、(7.42±5.6)平方毫米和(24.5±10.4)%。就翼状胬肉的形态而言,24 只眼睛为连续型,23 只眼睛为结节型,角膜前散光的中位数(四分位数间距)分别为 1.87(1.01-3.80)和 1.22 D(0.58-2.35)(P = 0.102)。各组之间的其他地形和翼状胬肉大小参数相似。分别分析各组的相关性,在连续组和结节组中,垂直宽度、扩展百分比、翼状胬肉面积和角膜前散光之间存在中度统计学意义的正相关:结论:尽管没有统计学意义,但连续性组的角膜前散光度数更高。使用 AS-OCT 对翼状胬肉的形态进行标准化可提供更多临床信息。
{"title":"Does pterygium morphology affect corneal astigmatism?","authors":"Emine Doğan, Burçin Çakır, Nilgün Aksoy, Elif Köse, Gürsoy Alagöz","doi":"10.1177/25158414211030423","DOIUrl":"10.1177/25158414211030423","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to evaluate the correlation between corneal astigmatism and the morphology of pterygium with anterior segment optic coherence tomography (AS-OCT).</p><p><strong>Material and methods: </strong>The size of pterygium (horizontal length, vertical width) was measured manually; pterygium area and percentage extension of the pterygium onto the cornea were calculated. Anterior and posterior corneal astigmatism, Sim K, K1, K2 were measured using a dual Scheimpflug analyzer. Morphological patterns of the pterygium analyzed with AS-OCT were determined according to the extension of the pterygium apex below the corneal epithelium. Two tomographic patterns were identified: continuous and nodular. Correlation between anterior corneal astigmatism and pterygium size, percentage extension of the pterygium, and morphological pattern of the pterygium was analyzed.</p><p><strong>Results: </strong>The mean ages of the 47 patients were 49.4 ± 16.6 (22-80) years. Mean horizontal pterygium length, vertical width, pterygium area, and percentage extension of the pterygium were 2.8 ± 1.2 mm, 4.8 ± 1.6 mm, 7.42 ± 5.6 mm<sup>2</sup> and 24.5 ± 10.4%, respectively. Mean anterior corneal astigmatism was 2.3 ± 2.3 D and simulated keratometry was 43.4 ± 2.02 D. In terms of the morphological pattern of the pterygium, 24 eyes had continuous, 23 eyes had a nodular pattern and the median (interquartile range) anterior corneal astigmatism was 1.87 (1.01-3.80) and 1.22 D (0.58-2.35), respectively (<i>p</i> = 0.102). Other topographic and pterygium size parameters were similar between groups. Analyzing the correlations in groups separately, a positive moderate statistically significant correlation was present between vertical width, percentage extension, pterygium area, and anterior corneal astigmatism in both continuous and nodular groups.</p><p><strong>Conclusions: </strong>Although not statistically significant, anterior corneal astigmatism was higher in continuous group. Using AS-OCT to standardize the morphology of pterygium could provide additional clinical information.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211030423"},"PeriodicalIF":2.3,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/b7/10.1177_25158414211030423.PMC8278454.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39207293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
KSI-301: antibody biopolymer conjugate in retinal disorders. KSI-301:视网膜疾病的抗体生物聚合物偶联物。
IF 2.5 Q2 OPHTHALMOLOGY Pub Date : 2021-07-12 eCollection Date: 2021-01-01 DOI: 10.1177/25158414211027708
Priya R Chandrasekaran, V G Madanagopalan

KSI-301 is a new intravitreal anti-vascular endothelial growth factor (VEGF) antibody biopolymer conjugate under investigation for the treatment of age-related macular degeneration (AMD), diabetic macular oedema (DME) and retinal vein occlusion (RVO). Preclinical and early clinical trials so far have shown promising results in retinal vascular diseases. When using anti-VEGF agents for treatment of retinal disorders, the frequency of injections and follow-up visits has increased the treatment burden, greatly affecting the treatment outcome. There are new anti-VEGF agents in the horizon with extended duration of action, durability, safety profile and efficacy, which seem to address the above issues. PubMed search and Medline search were performed on newer anti-VEGF agents, KSI-301, antibody biopolymer conjugate in retina, KODIAK KSI-301, DAZZLE study, GLEAM study, GLIMMER study, GLOW study and BEACON study. This review article showcases the biophysical properties and ongoing trials related to KSI-301. Moreover, we discuss the efficacy and safety profile of KSI-301 on the basis of the results of available trials.

KSI-301是一种新的玻璃体内抗血管内皮生长因子(VEGF)抗体生物聚合物偶联物,正在研究用于治疗年龄相关性黄斑变性(AMD)、糖尿病性黄斑水肿(DME)和视网膜静脉闭塞(RVO)。到目前为止,临床前和早期临床试验在视网膜血管疾病方面显示出有希望的结果。在使用抗vegf药物治疗视网膜疾病时,注射次数和随访次数增加了治疗负担,极大地影响了治疗效果。有新的抗vegf药物在地平线上,延长作用时间,耐久性,安全性和有效性,似乎解决了上述问题。PubMed检索和Medline检索更新的抗vegf药物,KSI-301,视网膜抗体生物聚合物偶联物,KODIAK KSI-301, DAZZLE研究,GLEAM研究,GLIMMER研究,GLOW研究和BEACON研究。这篇综述文章展示了与KSI-301相关的生物物理特性和正在进行的试验。此外,我们在现有试验结果的基础上讨论了KSI-301的有效性和安全性。
{"title":"KSI-301: antibody biopolymer conjugate in retinal disorders.","authors":"Priya R Chandrasekaran,&nbsp;V G Madanagopalan","doi":"10.1177/25158414211027708","DOIUrl":"https://doi.org/10.1177/25158414211027708","url":null,"abstract":"<p><p>KSI-301 is a new intravitreal anti-vascular endothelial growth factor (VEGF) antibody biopolymer conjugate under investigation for the treatment of age-related macular degeneration (AMD), diabetic macular oedema (DME) and retinal vein occlusion (RVO). Preclinical and early clinical trials so far have shown promising results in retinal vascular diseases. When using anti-VEGF agents for treatment of retinal disorders, the frequency of injections and follow-up visits has increased the treatment burden, greatly affecting the treatment outcome. There are new anti-VEGF agents in the horizon with extended duration of action, durability, safety profile and efficacy, which seem to address the above issues. PubMed search and Medline search were performed on newer anti-VEGF agents, KSI-301, antibody biopolymer conjugate in retina, KODIAK KSI-301, DAZZLE study, GLEAM study, GLIMMER study, GLOW study and BEACON study. This review article showcases the biophysical properties and ongoing trials related to KSI-301. Moreover, we discuss the efficacy and safety profile of KSI-301 on the basis of the results of available trials.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211027708"},"PeriodicalIF":2.5,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/25158414211027708","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39207368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Outcomes of lacrimal probing surgery as the first option in the treatment of congenital dacryocystocele. 泪囊探查手术作为治疗先天性泪囊炎首选方案的效果。
IF 2.5 Q2 OPHTHALMOLOGY Pub Date : 2021-07-09 eCollection Date: 2021-01-01 DOI: 10.1177/25158414211030427
Cetin Akpolat, Selam Yekta Sendul, Ebru Turkoglu Unal, Egemen Karatas, Cemile Ucgul Atilgan, Mehmet Demir

Purpose: To determine the demographic and clinical characteristics of newborn patients who underwent lacrimal probing surgical intervention with or without the marsupialization of intranasal cysts as the primary management for dacryocystocele treatment.

Methods: Data from the medical charts of 350 infants who underwent lacrimal probing surgery due to nasolacrimal duct obstruction were reviewed retrospectively. Ten newborn patients with a naive diagnosis of congenital dacryocystocele were included in the study. Congenital dacryocystocele diagnosis was based on a triad of swelling in the inner canthal region, a bluish appearance, and epiphora. Lacrimal probing surgery accompanied by nasal endoscopy was planned for all patients as the first treatment option.

Results: The mean age of the patients was 24.90 ± 7.15 days, with a range of 6-85 days. A total of 10 patients were included, comprising seven females and three males. The mean postoperative follow-up period was 38.7 ± 24.41 months. Five patients had left, four patients had right, and one patient had bilateral dacryocystocele. Seven eyes of the six patients had uncomplicated dacryocystocele, while the remaining patients had dacryocystocele with complications of dacryocystitis and/or preseptal cellulitis. All patients had intranasal cysts. All patients underwent one session of lacrimal probing surgery under general anesthesia; all with successful outcomes. Four patients with additional dacryocystocele-associated complications underwent combined intranasal marsupialization of the cyst wall.

Discussion: Lacrimal probing surgery ± intranasal marsupialization of the cyst wall as a first treatment option can be effective for both congenital dacryocystocele and/or congenital dacryocystocele plus associated complications and provide complete resolution of dacryocystocele-related symptoms.

目的:确定接受泪道探查手术治疗的新生儿患者的人口统计学和临床特征,这些患者接受或不接受鼻内囊肿沼泽化手术作为治疗泪囊炎的主要方法:回顾性分析了350名因鼻泪管阻塞而接受泪道探查手术的婴儿的病历资料。研究还包括 10 名被诊断为先天性泪囊炎的新生儿。先天性泪囊炎的诊断依据是眼眶内区肿胀、外观发蓝和眼睑外翻这三点。作为首选治疗方案,所有患者都计划接受泪囊探查手术和鼻内窥镜检查:患者的平均年龄为 24.90±7.15 天,年龄范围为 6-85 天。共纳入 10 名患者,包括 7 名女性和 3 名男性。术后平均随访时间为(38.7 ± 24.41)个月。五名患者为左眼,四名患者为右眼,一名患者为双侧泪囊炎。六名患者中有七名无并发症的泪囊炎患者,其余患者的泪囊炎并发泪囊炎和/或泪囊前蜂窝织炎。所有患者都有鼻内囊肿。所有患者都在全身麻醉的情况下接受了一次泪道探查手术,均取得了成功。四名有泪囊肿相关并发症的患者接受了鼻内囊肿囊壁联合切除术:讨论:泪囊探查手术和囊壁鼻内填塞术是治疗先天性泪囊炎和/或先天性泪囊炎及其相关并发症的首选方法,可有效彻底解决泪囊炎相关症状。
{"title":"Outcomes of lacrimal probing surgery as the first option in the treatment of congenital dacryocystocele.","authors":"Cetin Akpolat, Selam Yekta Sendul, Ebru Turkoglu Unal, Egemen Karatas, Cemile Ucgul Atilgan, Mehmet Demir","doi":"10.1177/25158414211030427","DOIUrl":"10.1177/25158414211030427","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the demographic and clinical characteristics of newborn patients who underwent lacrimal probing surgical intervention with or without the marsupialization of intranasal cysts as the primary management for dacryocystocele treatment.</p><p><strong>Methods: </strong>Data from the medical charts of 350 infants who underwent lacrimal probing surgery due to nasolacrimal duct obstruction were reviewed retrospectively. Ten newborn patients with a naive diagnosis of congenital dacryocystocele were included in the study. Congenital dacryocystocele diagnosis was based on a triad of swelling in the inner canthal region, a bluish appearance, and epiphora. Lacrimal probing surgery accompanied by nasal endoscopy was planned for all patients as the first treatment option.</p><p><strong>Results: </strong>The mean age of the patients was 24.90 ± 7.15 days, with a range of 6-85 days. A total of 10 patients were included, comprising seven females and three males. The mean postoperative follow-up period was 38.7 ± 24.41 months. Five patients had left, four patients had right, and one patient had bilateral dacryocystocele. Seven eyes of the six patients had uncomplicated dacryocystocele, while the remaining patients had dacryocystocele with complications of dacryocystitis and/or preseptal cellulitis. All patients had intranasal cysts. All patients underwent one session of lacrimal probing surgery under general anesthesia; all with successful outcomes. Four patients with additional dacryocystocele-associated complications underwent combined intranasal marsupialization of the cyst wall.</p><p><strong>Discussion: </strong>Lacrimal probing surgery ± intranasal marsupialization of the cyst wall as a first treatment option can be effective for both congenital dacryocystocele and/or congenital dacryocystocele plus associated complications and provide complete resolution of dacryocystocele-related symptoms.</p>","PeriodicalId":23054,"journal":{"name":"Therapeutic Advances in Ophthalmology","volume":"13 ","pages":"25158414211030427"},"PeriodicalIF":2.5,"publicationDate":"2021-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f5/bc/10.1177_25158414211030427.PMC8274130.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39207294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Therapeutic Advances in Ophthalmology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1