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Proceedings: The histochemical assay of plasminogen activator in the venous wall--an inter-ethnic study. 研究进展:静脉壁纤溶酶原激活剂的组织化学分析——一项种族间研究。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
R C Franz, N Hugo, C R Jansen
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引用次数: 0
Proceedings: Purification of tissue activator using affinity adsorption on fibrin and hydrophobic interaction chromatography. Effect of fibrin on the enzymatic properties of the activator. 研究进展:纤维蛋白亲和吸附和疏水相互作用层析纯化组织活化剂。纤维蛋白对活化剂酶学性质的影响。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
P Wallén, B Wiman
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引用次数: 0
Proceedings: Factor VIII, small active factor VIII fragments, and von Willebrand factor. 会议录:因子VIII，小活性因子VIII片段，和血管性血友病因子。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
R H Wagner
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引用次数: 0
Proceedings: Factor VIII related antigen in normal blood platelets and in platelets of patients with von Willebrand's disease. 研究进展:正常血小板和血管性血友病患者血小板中的因子VIII相关抗原
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
B N Bouma, J M Hordijk-Hos, S de Graaf, J A van Mourik, J J Sixma
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引用次数: 0
Proceedings: Mechanisms of the prolonged bleeding time in von Willebrand's disease (vWd). 血管性血友病(vWd)出血时间延长的机制。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
P M Mannucci, L Holmberg, Z M Ruggeri, I M Nilsson
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引用次数: 0
Proceedings: Receptors for 5-hydroxytryptamine on rat blood platelets. 研究进展:大鼠血小板5-羟色胺受体。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
A H Drummond, J L Gordon
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引用次数: 0
Proceedings: Activation of dicoumarol-induced atypical prothrombin. 研究进展:双酚醇诱导非典型凝血酶原的激活。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
O P Malhotra
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引用次数: 0
Effects of experimental coronary thrombosis upon regional and systemic plasma chromatographic patterns. 实验性冠状动脉血栓形成对区域和全身血浆色谱模式的影响。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
P Chowdhury, C B Moschos

An evaluation of changes in the plasma chromatographic pattern was carried out in dogs with experimental coronary thrombosis. Sequential samples were taken simultaneously from the aorta and coronary sinus over a two, four and twenty-four hour period. In addition to gel-chromatography, immunodiffusion and electrophoresis were also employed to identify the protein components of the elution fractions. The results showed that there was a shift of the normal chromatographic pattern to the left from the control within two hours following thrombotic occlusion of the coronary artery and it was maintained over a twenty-four hour period. The shift to the left was presumably due to the earlier elution of the heavy molecular weight components forming as a result of the thrombotic process. The early appearance of the altered chromatographic pattern constitutes an important advantage worthy of further exploration for possible diagnostic application in the human subject.

对实验性冠状动脉血栓形成犬的血浆色谱图变化进行了评价。在2小时、4小时和24小时的时间内，同时从主动脉和冠状动脉窦连续取样。除凝胶层析法外，免疫扩散法和电泳法也用于鉴定洗脱组分的蛋白质成分。结果表明，在冠状动脉血栓闭塞后2小时内，正常的色谱模式从对照组向左移动，并维持了24小时。左移可能是由于由于血栓形成过程而形成的重分子量组分的较早洗脱。早期出现的改变的色谱模式构成了一个重要的优势，值得进一步探索可能的诊断应用在人类受试者。
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引用次数: 0
Proceedings: Immunohistological studies of coagulation factors in normal blood vessels and platelets. 会议录:正常血管和血小板中凝血因子的免疫组织学研究。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
A L Bloom, J C Giddings, S A Shearn
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引用次数: 0
Assessment of different mathematical models for calculating and expressing the results of coagulation test procedures. 评价计算和表达凝血试验程序结果的不同数学模型。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
J Kahan, I Norén

Coagulation activity, expressed as percentage of normal and as clotting time ratio, was estimated in 220 specimens from patients on long-term anticoagulant treatment by 3 different coagulation test procedures, i.e. Thrombotest, Simplastin-A and Normotest. The estimates were calculated from the same determinations. The distribution of percentage values showed a fairly pronounced deviation from normality. After logarithmic transformation, the distribution was normalized, the regression lines between Thrombotest and other tests became parallel, and that between PIVKA-insensitive systems was shifted to a 45 degree line. Logarithmic transformation also stabilized the residual variance. These features make percentage values accessible for treatment according to the standard methods of bioassay statistics. Attempts to normalize the distribution of ratio values by various transformations were unsuccessful. Formal analysis of data revealed a variation in the proportionality of ratio values with the level of estimated coagulation defect. This may restrict the usefulness of the ratio approach. Logarithmic transformation partly reduced the discrepancy.

通过3种不同的凝血试验程序，即Thrombotest、Simplastin-A和Normotest，对长期抗凝治疗患者的220例标本进行凝血活性评估，以正常百分比和凝血时间比率表示。这些估计值是根据相同的决定计算出来的。百分比值的分布与正态性有相当明显的偏差。对数变换后，分布归一化，凝血试验与其他试验之间的回归线平行，pivka不敏感系统之间的回归线移位为45度线。对数变换也稳定了残差方差。这些特征使百分比值可以根据生物测定统计的标准方法进行治疗。试图通过各种变换使比率值的分布归一化是不成功的。数据的正式分析揭示了比例值与估计凝血缺陷水平的比例性变化。这可能会限制比率法的有效性。对数变换在一定程度上减小了差异。
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引用次数: 0
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