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Thrombosis et diathesis haemorrhagica最新文献

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Proceedings: Comparative investigations on factor VIII assays. 会议录:因子VIII测定的比较调查。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
R Pflugshaupt, S Moser, K Züger, R Bütler
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引用次数: 0
Proceedings: Inhibition of bovine factor VIII and ristocetin plus human factor VIII induced platelet agglutination by small peptides. 研究进展:用小肽抑制牛凝血因子VIII和雷斯托司汀加人凝血因子VIII诱导血小板凝集。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
D E Macfarlane
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引用次数: 0
Effects of experimental coronary thrombosis upon regional and systemic plasma chromatographic patterns. 实验性冠状动脉血栓形成对区域和全身血浆色谱模式的影响。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
P Chowdhury, C B Moschos

An evaluation of changes in the plasma chromatographic pattern was carried out in dogs with experimental coronary thrombosis. Sequential samples were taken simultaneously from the aorta and coronary sinus over a two, four and twenty-four hour period. In addition to gel-chromatography, immunodiffusion and electrophoresis were also employed to identify the protein components of the elution fractions. The results showed that there was a shift of the normal chromatographic pattern to the left from the control within two hours following thrombotic occlusion of the coronary artery and it was maintained over a twenty-four hour period. The shift to the left was presumably due to the earlier elution of the heavy molecular weight components forming as a result of the thrombotic process. The early appearance of the altered chromatographic pattern constitutes an important advantage worthy of further exploration for possible diagnostic application in the human subject.

对实验性冠状动脉血栓形成犬的血浆色谱图变化进行了评价。在2小时、4小时和24小时的时间内，同时从主动脉和冠状动脉窦连续取样。除凝胶层析法外，免疫扩散法和电泳法也用于鉴定洗脱组分的蛋白质成分。结果表明，在冠状动脉血栓闭塞后2小时内，正常的色谱模式从对照组向左移动，并维持了24小时。左移可能是由于由于血栓形成过程而形成的重分子量组分的较早洗脱。早期出现的改变的色谱模式构成了一个重要的优势，值得进一步探索可能的诊断应用在人类受试者。
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引用次数: 0
Assessment of different mathematical models for calculating and expressing the results of coagulation test procedures. 评价计算和表达凝血试验程序结果的不同数学模型。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
J Kahan, I Norén

Coagulation activity, expressed as percentage of normal and as clotting time ratio, was estimated in 220 specimens from patients on long-term anticoagulant treatment by 3 different coagulation test procedures, i.e. Thrombotest, Simplastin-A and Normotest. The estimates were calculated from the same determinations. The distribution of percentage values showed a fairly pronounced deviation from normality. After logarithmic transformation, the distribution was normalized, the regression lines between Thrombotest and other tests became parallel, and that between PIVKA-insensitive systems was shifted to a 45 degree line. Logarithmic transformation also stabilized the residual variance. These features make percentage values accessible for treatment according to the standard methods of bioassay statistics. Attempts to normalize the distribution of ratio values by various transformations were unsuccessful. Formal analysis of data revealed a variation in the proportionality of ratio values with the level of estimated coagulation defect. This may restrict the usefulness of the ratio approach. Logarithmic transformation partly reduced the discrepancy.

通过3种不同的凝血试验程序，即Thrombotest、Simplastin-A和Normotest，对长期抗凝治疗患者的220例标本进行凝血活性评估，以正常百分比和凝血时间比率表示。这些估计值是根据相同的决定计算出来的。百分比值的分布与正态性有相当明显的偏差。对数变换后，分布归一化，凝血试验与其他试验之间的回归线平行，pivka不敏感系统之间的回归线移位为45度线。对数变换也稳定了残差方差。这些特征使百分比值可以根据生物测定统计的标准方法进行治疗。试图通过各种变换使比率值的分布归一化是不成功的。数据的正式分析揭示了比例值与估计凝血缺陷水平的比例性变化。这可能会限制比率法的有效性。对数变换在一定程度上减小了差异。
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引用次数: 0
Letter: Accelerated hemostasis in chloroquine-treated rats. 字母:氯喹治疗大鼠加速止血。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
W F Ward, F I Lipschutz, E W Hahn
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引用次数: 0
Proceedings: Electron microscopic studies of the molecular shape of fibrinogen molecule. 研究进展:纤维蛋白原分子形态的电镜研究。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
L Tranqui, V L Marder, M Suscillon, A Z Budzynski, G Hudry
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引用次数: 0
Proceedings: Duration of the inhibition effect of acetylsalicylic acid on human platelet function. 研究进展:乙酰水杨酸对人血小板功能抑制作用的持续时间。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
G Baele, L Verdonck, A Vermeulen, F Barbier
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引用次数: 0
Proceedings: Leucocytes and platelets in isolated lung perfusion. 研究进展:孤立肺灌注中的白细胞和血小板。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
N van Zandwijk, T F Lenssen, E M Prakke, J van der Meer, A S Groen
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引用次数: 0
Proceedings: Inhibition of ristocetin-induced platelet aggregation (RIPA) by Haemaccel and fibrinogen. 血凝素和纤维蛋白原抑制利斯托司汀诱导的血小板聚集(RIPA)。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
J Stibbe, E Kirby
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引用次数: 0
Proceedings: Comparison of in vivo and in vitro effects of platelet function suppressing drugs. 研究进展:血小板功能抑制药物体内和体外作用的比较。
Thrombosis et diathesis haemorrhagica
Pub Date : 1975-11-15
M Buchanan, J Hirsh
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引用次数: 0
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