Pub Date : 2021-12-31DOI: 10.17945/kjbt.2021.32.3.163
Kiwook Jung, Jikyo Lee, J. Kang, M.T., Jae Hyeon Park, Yousun Chung, Dae-Hyun Ko, Hyungsuk Kim, K. Han
Background: Pretransfusion testing is vital for safe transfusion. However, in situations without time to perform sufficient testing, all or part of the pretransfusion testing may be skipped to issue blood quickly. This study evaluated the safety of red blood cell (RBC) transfusion released by an emergency blood transfusion protocol through retrospective analysis at a tertiary hospital for eight years. Methods: All RBC transfusions following the emergency blood transfusion protocol from 2011 to 2018 at Seoul National University Hospital were included in the study. Crossmatching and unexpected antibody screening test results conducted after RBC release and the occurrence of hemolytic transfusion reactions were analyzed. Results: A total of 1,541 cases (5,299 RBCs issued) of emergency blood transfusion were identified. RBCs were issued after performing the immediate spin crossmatch without an unexpected antibody screening test in most cases (1,443; 93.64%), while RBCs were issued with no pretransfusion testing in 98 cases (6.36%). Antibody screening tests performed after the issue of RBCs showed that 17 (1.1%) cases were positive. Two units of RBCs from two different cases showed positive antiglobulin crossmatch test results. However, none of them were suspected to be associated with a hemolytic transfusion reaction. Conclusion: The incidence of incompatible RBC release was very low in patients receiving RBC transfusion through the emergency blood transfusion protocol suggesting it can be used safely with minimal risk of hemolytic transfusion reactions caused by incompatible blood transfusions. (Korean J Blood Transfus 2021;32:163-173)
{"title":"Safety of Red Blood Cell Transfusion by the Emergency Blood Transfusion Protocol","authors":"Kiwook Jung, Jikyo Lee, J. Kang, M.T., Jae Hyeon Park, Yousun Chung, Dae-Hyun Ko, Hyungsuk Kim, K. Han","doi":"10.17945/kjbt.2021.32.3.163","DOIUrl":"https://doi.org/10.17945/kjbt.2021.32.3.163","url":null,"abstract":"Background: Pretransfusion testing is vital for safe transfusion. However, in situations without time to perform sufficient testing, all or part of the pretransfusion testing may be skipped to issue blood quickly. This study evaluated the safety of red blood cell (RBC) transfusion released by an emergency blood transfusion protocol through retrospective analysis at a tertiary hospital for eight years. Methods: All RBC transfusions following the emergency blood transfusion protocol from 2011 to 2018 at Seoul National University Hospital were included in the study. Crossmatching and unexpected antibody screening test results conducted after RBC release and the occurrence of hemolytic transfusion reactions were analyzed. Results: A total of 1,541 cases (5,299 RBCs issued) of emergency blood transfusion were identified. RBCs were issued after performing the immediate spin crossmatch without an unexpected antibody screening test in most cases (1,443; 93.64%), while RBCs were issued with no pretransfusion testing in 98 cases (6.36%). Antibody screening tests performed after the issue of RBCs showed that 17 (1.1%) cases were positive. Two units of RBCs from two different cases showed positive antiglobulin crossmatch test results. However, none of them were suspected to be associated with a hemolytic transfusion reaction. Conclusion: The incidence of incompatible RBC release was very low in patients receiving RBC transfusion through the emergency blood transfusion protocol suggesting it can be used safely with minimal risk of hemolytic transfusion reactions caused by incompatible blood transfusions. (Korean J Blood Transfus 2021;32:163-173)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"381 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116056898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.17945/kjbt.2021.32.3.181
D. Seo, Hyoung-Ju Yoon, Jae Chan Ahn, Y. Hwang.
Background: According to blood management law, serology and nucleic acid testing (NAT) are performed for HIV, HBV, HCV, and others as blood screening tests in Korea. The blood screening tests for HIV, HBV, and HCV have substantially improved transfusion safety. The blood screening results of one blood center were investigated because there is little domestic data available on screening tests. Methods: The blood donation records and screening tests results of a supplying blood center were analyzed retrospectively from January 2011 to December 2020 in Korea. Annual first-time donation numbers, sex, and age distribution of donors were investigated during 10 years. The positivity of ALT, HBsAg, anti-HCV, and anti-HIV antibody testing and the positive cases of HIV, HCV, and HBV NAT were inquired. Results: For 10 years, the blood center has collected 1,896,392 units of blood, and male donation was 1,239,873 units, which was 65.38% of total blood donation. ALT abnormal blood units were 2.06% in 2011, 2.14% in 2013, and 0.81% in 2019. The donor screening test showed HBsAg 0.03%, anti-HCV 0.02%, and anti-HIV 0.06% positivity at 2020. NAT yield cases were three with HIV, two with HCV, and 260 with HBV for 10 years. Conclusion: The positivity of serology screening tests of the Hanmaeum blood center showed a decreasing trend, and the transfusion of nucleic acid positive but serologically negative blood could be prevented by performing NAT. (Korean J Blood Transfus 2021;32:181-190)
{"title":"Analysis of Results of Donor Blood Screening Tests of Hanmaeum Blood Center (2011~2020)","authors":"D. Seo, Hyoung-Ju Yoon, Jae Chan Ahn, Y. Hwang.","doi":"10.17945/kjbt.2021.32.3.181","DOIUrl":"https://doi.org/10.17945/kjbt.2021.32.3.181","url":null,"abstract":"Background: According to blood management law, serology and nucleic acid testing (NAT) are performed for HIV, HBV, HCV, and others as blood screening tests in Korea. The blood screening tests for HIV, HBV, and HCV have substantially improved transfusion safety. The blood screening results of one blood center were investigated because there is little domestic data available on screening tests. Methods: The blood donation records and screening tests results of a supplying blood center were analyzed retrospectively from January 2011 to December 2020 in Korea. Annual first-time donation numbers, sex, and age distribution of donors were investigated during 10 years. The positivity of ALT, HBsAg, anti-HCV, and anti-HIV antibody testing and the positive cases of HIV, HCV, and HBV NAT were inquired. Results: For 10 years, the blood center has collected 1,896,392 units of blood, and male donation was 1,239,873 units, which was 65.38% of total blood donation. ALT abnormal blood units were 2.06% in 2011, 2.14% in 2013, and 0.81% in 2019. The donor screening test showed HBsAg 0.03%, anti-HCV 0.02%, and anti-HIV 0.06% positivity at 2020. NAT yield cases were three with HIV, two with HCV, and 260 with HBV for 10 years. Conclusion: The positivity of serology screening tests of the Hanmaeum blood center showed a decreasing trend, and the transfusion of nucleic acid positive but serologically negative blood could be prevented by performing NAT. (Korean J Blood Transfus 2021;32:181-190)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125237851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.17945/kjbt.2021.32.3.174
Hee-Jeong Youk, Yousun Chung, Hyungsuk Kim, Sang-Hyun Hwang, Heung-Bum Oh, D. Ko
Background: According to the revision of the Blood Management Act in 2020, medical institutions that meet certain conditions are obliged to install a transfusion management division in Korea. Therefore, this study assessed the management status of the transfusion management division at major medical institutions. Methods: From August 7th to August 18th, 2021, a survey questionnaire was given to laboratory physicians of 10 major medical institutions in Korea, and the installation and operation of the transfusion management division were surveyed. Results: The medical institutions that participated in this survey completed a transfusion management division in the first half of the year. Doctors, nurses, and medical technologists were assigned as medical personnel, and all laboratory physicians were leading the work as the head of the transfusion management division. Regarding the tasks performed at the transfusion management division, all medical institutions conducted a transfusion appropriateness assessment, education related to transfusion, and adverse transfusion reactions. Most medical institutions had difficulties because there was an insufficient basis to calculate the workforce and budget in installing and operating the transfusion management division. Conclusion: There are rarely reference materials for the practice and operation of the transfusion management division, which has no precedent in Korea, so it is often difficult for medical institutions to prepare it. This study will be a reference for medical institutions that need to install a transfusion management division in the future. Efforts should be made to legislate transfusion management fees focused on the academic community. (Korean J Blood Transfus 2021;32:174-180)
{"title":"Current Status of Management for Transfusion Management Division at Ten Medical Institutions in Korea","authors":"Hee-Jeong Youk, Yousun Chung, Hyungsuk Kim, Sang-Hyun Hwang, Heung-Bum Oh, D. Ko","doi":"10.17945/kjbt.2021.32.3.174","DOIUrl":"https://doi.org/10.17945/kjbt.2021.32.3.174","url":null,"abstract":"Background: According to the revision of the Blood Management Act in 2020, medical institutions that meet certain conditions are obliged to install a transfusion management division in Korea. Therefore, this study assessed the management status of the transfusion management division at major medical institutions. Methods: From August 7th to August 18th, 2021, a survey questionnaire was given to laboratory physicians of 10 major medical institutions in Korea, and the installation and operation of the transfusion management division were surveyed. Results: The medical institutions that participated in this survey completed a transfusion management division in the first half of the year. Doctors, nurses, and medical technologists were assigned as medical personnel, and all laboratory physicians were leading the work as the head of the transfusion management division. Regarding the tasks performed at the transfusion management division, all medical institutions conducted a transfusion appropriateness assessment, education related to transfusion, and adverse transfusion reactions. Most medical institutions had difficulties because there was an insufficient basis to calculate the workforce and budget in installing and operating the transfusion management division. Conclusion: There are rarely reference materials for the practice and operation of the transfusion management division, which has no precedent in Korea, so it is often difficult for medical institutions to prepare it. This study will be a reference for medical institutions that need to install a transfusion management division in the future. Efforts should be made to legislate transfusion management fees focused on the academic community. (Korean J Blood Transfus 2021;32:174-180)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129750451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.17945/kjbt.2021.32.3.191
H. Bae, Byong Sun Ahn, Mi Ae Youn, Don Young Park
Background: This study investigated the recognition of employees and blood donors regarding the spread of COVID-19 and the response of the Korean Red Cross Blood Service. Methods: An online survey was conducted through internal groupware targeting employees of the Korean Red Cross Blood Center and Blood Laboratory Center. For the blood donor survey, a text message containing the survey URL was sent to 20,000 blood donors on July 31, 2020, and the responses were analyzed. Results: Of those who received text messages, 63.7% of staff and 8.6% of blood donors participated. Of the employees surveyed, the greatest urgency was the need to prepare after COVID-19; strengthening safety and protection measures of employees showed the highest result. In the concern on future blood services, the highest result was the deterioration of blood supply due to decreasing number of blood donors. In a survey of blood donors, 16.0% answered that the spread of COVID-19 had a very negative or somewhat negative effect on the recognition of blood donation, and 80.4% responded positively to sending an ‘emergency disaster message requesting blood donation’ when blood stocks dropped sharply. Conclusion: It is necessary to expand blood donation promotion and prepare systematic blood donor management measures for a stable blood supply during a pandemic, such as COVID-19. The emergency disaster message requesting blood donation helped solve the blood shortage, but it appears that an effective use plan will be needed in the future. (Korean J Blood Transfus 2021;32:191-200)
{"title":"Survey on Blood Donation Recognition and Korean Red Cross’ Response during COVID-19 Pandemic","authors":"H. Bae, Byong Sun Ahn, Mi Ae Youn, Don Young Park","doi":"10.17945/kjbt.2021.32.3.191","DOIUrl":"https://doi.org/10.17945/kjbt.2021.32.3.191","url":null,"abstract":"Background: This study investigated the recognition of employees and blood donors regarding the spread of COVID-19 and the response of the Korean Red Cross Blood Service. Methods: An online survey was conducted through internal groupware targeting employees of the Korean Red Cross Blood Center and Blood Laboratory Center. For the blood donor survey, a text message containing the survey URL was sent to 20,000 blood donors on July 31, 2020, and the responses were analyzed. Results: Of those who received text messages, 63.7% of staff and 8.6% of blood donors participated. Of the employees surveyed, the greatest urgency was the need to prepare after COVID-19; strengthening safety and protection measures of employees showed the highest result. In the concern on future blood services, the highest result was the deterioration of blood supply due to decreasing number of blood donors. In a survey of blood donors, 16.0% answered that the spread of COVID-19 had a very negative or somewhat negative effect on the recognition of blood donation, and 80.4% responded positively to sending an ‘emergency disaster message requesting blood donation’ when blood stocks dropped sharply. Conclusion: It is necessary to expand blood donation promotion and prepare systematic blood donor management measures for a stable blood supply during a pandemic, such as COVID-19. The emergency disaster message requesting blood donation helped solve the blood shortage, but it appears that an effective use plan will be needed in the future. (Korean J Blood Transfus 2021;32:191-200)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129178509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.17945/kjbt.2021.32.3.209
Kae Lyang Koo, Hyun Ki Min, Hyun Ji Lee
The blood management act was revised on December 4, 2020, to enhance transfusion management and has been established in accordance with the department of transfusion management in the medical institution. The department of transfusion management is involved in education related to transfusion, transfusion monitoring, and ward rounding. The department of transfusion management is essential for promoting the stability and safety of transfusions. This paper aims to help the department of transfusion management operation by sharing the experience of the department of transfusion management. (Korean J Blood Transfus 2021;32:209-216)
{"title":"Experience in Establishing Department of Transfusion Management","authors":"Kae Lyang Koo, Hyun Ki Min, Hyun Ji Lee","doi":"10.17945/kjbt.2021.32.3.209","DOIUrl":"https://doi.org/10.17945/kjbt.2021.32.3.209","url":null,"abstract":"The blood management act was revised on December 4, 2020, to enhance transfusion management and has been established in accordance with the department of transfusion management in the medical institution. The department of transfusion management is involved in education related to transfusion, transfusion monitoring, and ward rounding. The department of transfusion management is essential for promoting the stability and safety of transfusions. This paper aims to help the department of transfusion management operation by sharing the experience of the department of transfusion management. (Korean J Blood Transfus 2021;32:209-216)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115629144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.17945/kjbt.2021.32.3.201
E. Yoon, Tae Yeul Kim, Sun Kyoung Mun, D. Cho
hemolytic anemia, have been reported in patients treated with immune checkpoint inhibitors. In particular, RBC autoantibodies are important because they can cause hemolytic anemia and interfere with pre-transfusion tests. On the other hand, there are few reports on the characteristics of RBC autoantibodies induced by immune checkpoint inhibitors in Korea. The medical history and laboratory results, including pretransfusion tests of ten patients treated with immune checkpoint inhibitors, were reviewed retrospectively. The median interval from the first administration of immune checkpoint inhibitors to the development of autoantibodies was 12 weeks. In eight patients, only cold autoantibodies were developed. Both warm and cold autoantibodies developed in one patient, and warm autoantibodies alone were detected in one patient. Of seven patients tested by a direct antiglobulin test, two were negative, and the remaining five were positive for IgG and negative for C3d. In conclusion, this study presented ten cases of autoantibody developments in patients treated with immune checkpoint inhibitors and the possible relationship between the immune checkpoint inhibitors and RBC autoantibody development. Further comprehensive studies will be needed to elucidate this relationship.
{"title":"Red Blood Cell Autoantibodies in Patients Treated with Immune Checkpoint Inhibitors","authors":"E. Yoon, Tae Yeul Kim, Sun Kyoung Mun, D. Cho","doi":"10.17945/kjbt.2021.32.3.201","DOIUrl":"https://doi.org/10.17945/kjbt.2021.32.3.201","url":null,"abstract":"hemolytic anemia, have been reported in patients treated with immune checkpoint inhibitors. In particular, RBC autoantibodies are important because they can cause hemolytic anemia and interfere with pre-transfusion tests. On the other hand, there are few reports on the characteristics of RBC autoantibodies induced by immune checkpoint inhibitors in Korea. The medical history and laboratory results, including pretransfusion tests of ten patients treated with immune checkpoint inhibitors, were reviewed retrospectively. The median interval from the first administration of immune checkpoint inhibitors to the development of autoantibodies was 12 weeks. In eight patients, only cold autoantibodies were developed. Both warm and cold autoantibodies developed in one patient, and warm autoantibodies alone were detected in one patient. Of seven patients tested by a direct antiglobulin test, two were negative, and the remaining five were positive for IgG and negative for C3d. In conclusion, this study presented ten cases of autoantibody developments in patients treated with immune checkpoint inhibitors and the possible relationship between the immune checkpoint inhibitors and RBC autoantibody development. Further comprehensive studies will be needed to elucidate this relationship.","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121847808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.17945/kjbt.2021.32.2.102
J. Lee, Jae Sook Lee, Deukim Ko, Jiyeong Seon, Jin Hyuk Yang, Jun Nyun Kim, Mi Ae Youn
Background: The purpose of this study was to prepare data for the prevention and management of iron deficiency by analyzing the effects of taking iron supplements provided by blood centers for repeat blood donors. Methods: The high-risk groups with a potential iron deficiency were defined as three or more whole blood donations within the previous year and were provided with iron supplements for three months. Their hemoglobin and ferritin levels were checked up once a month for six months. The effectiveness of the iron supplements was evaluated by analyzing the changes in the initial and monthly hemoglobin and ferritin results. Results: At the time of recruitments, an average 50.4% (40.8% of men and 65.3% of women, respectively) of participants had ferritin levels of less than 15 ng/mL, the World Health Organization iron deficiency standard, but after three months iron supplementation, the results decreased to 10.9% (9.0% of men and 13.8% of women). The ferritin levels increased significantly after taking iron supplements for three months and showed significant increases in both men and women, particularly after two months ( P ＜ 0.05). Conclusion: The dietary iron supplements containing low-dose iron were effective in preventing iron deficiency in repeat blood donors by increasing the ferritin levels. (Korean J Blood Transfus 2021;32:102-111)
{"title":"Effects of Iron Dietary Supplements to Prevent Iron Deficiency in Repeat Blood Donors","authors":"J. Lee, Jae Sook Lee, Deukim Ko, Jiyeong Seon, Jin Hyuk Yang, Jun Nyun Kim, Mi Ae Youn","doi":"10.17945/kjbt.2021.32.2.102","DOIUrl":"https://doi.org/10.17945/kjbt.2021.32.2.102","url":null,"abstract":"Background: The purpose of this study was to prepare data for the prevention and management of iron deficiency by analyzing the effects of taking iron supplements provided by blood centers for repeat blood donors. Methods: The high-risk groups with a potential iron deficiency were defined as three or more whole blood donations within the previous year and were provided with iron supplements for three months. Their hemoglobin and ferritin levels were checked up once a month for six months. The effectiveness of the iron supplements was evaluated by analyzing the changes in the initial and monthly hemoglobin and ferritin results. Results: At the time of recruitments, an average 50.4% (40.8% of men and 65.3% of women, respectively) of participants had ferritin levels of less than 15 ng/mL, the World Health Organization iron deficiency standard, but after three months iron supplementation, the results decreased to 10.9% (9.0% of men and 13.8% of women). The ferritin levels increased significantly after taking iron supplements for three months and showed significant increases in both men and women, particularly after two months ( P ＜ 0.05). Conclusion: The dietary iron supplements containing low-dose iron were effective in preventing iron deficiency in repeat blood donors by increasing the ferritin levels. (Korean J Blood Transfus 2021;32:102-111)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114312815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.17945/kjbt.2021.32.2.112
Sooin Choi, Eun Young Kim, Hyungsuk Kim, D. Cho
Background: In ABO-incompatible (ABOi) solid organ transplantation, the minimization and management of isoagglutinin (IA) against donor ABO antigens between before and two weeks after transplantation is important for preventing hyper-acute rejection. Several factors that can affect the IA titer have been reported. This is the first study to evaluate whether there are IA titer differences between kidney transplantation (KT) and liver transplantation (LT) recipients. Methods: Thirty-eight KT and 32 LT type O recipients, who underwent ABOi KT or LT between March 2013 and March 2018, were enrolled consecutively. The IgM IA and IgG IA titers of the LT and KT recipients at different time points (initial, operation day [day-0], postoperative one week, four weeks, and one year) were evaluated. Results: The LT recipients showed higher initial IgG IA titers than the KT recipients (P=0.01). This higher titer in the LT recipients persisted during the critical phase (from before transplantation to postoperative one week). The IgG and IgM IA titers were similar in the KT and LT recipients at postoperative four weeks. Conclusion: The difference in IA titer between the underlying diseases should be considered in the desensitization protocol before ABOi SOT. (Korean J Blood Transfus 2021;32:112-122)
{"title":"Liver Failure Has Higher IgG ABO Blood Group Isoagglutinin Titer than Kidney Failure","authors":"Sooin Choi, Eun Young Kim, Hyungsuk Kim, D. Cho","doi":"10.17945/kjbt.2021.32.2.112","DOIUrl":"https://doi.org/10.17945/kjbt.2021.32.2.112","url":null,"abstract":"Background: In ABO-incompatible (ABOi) solid organ transplantation, the minimization and management of isoagglutinin (IA) against donor ABO antigens between before and two weeks after transplantation is important for preventing hyper-acute rejection. Several factors that can affect the IA titer have been reported. This is the first study to evaluate whether there are IA titer differences between kidney transplantation (KT) and liver transplantation (LT) recipients. Methods: Thirty-eight KT and 32 LT type O recipients, who underwent ABOi KT or LT between March 2013 and March 2018, were enrolled consecutively. The IgM IA and IgG IA titers of the LT and KT recipients at different time points (initial, operation day [day-0], postoperative one week, four weeks, and one year) were evaluated. Results: The LT recipients showed higher initial IgG IA titers than the KT recipients (P=0.01). This higher titer in the LT recipients persisted during the critical phase (from before transplantation to postoperative one week). The IgG and IgM IA titers were similar in the KT and LT recipients at postoperative four weeks. Conclusion: The difference in IA titer between the underlying diseases should be considered in the desensitization protocol before ABOi SOT. (Korean J Blood Transfus 2021;32:112-122)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129896237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.17945/kjbt.2021.32.2.132
Kyung-Hwa Shin, Hyun Ji Lee, Hyung-Hoi Kim
The anti-K antibody has a role in transfusion reactions or hemolytic disease of the fetus and newborns. The K antigen is rarely expressed in Koreans. On the other hand, the distribution of blood group antigens has changed in recent years owing to the increased number of immigrants. This study examined the prevalence of the Kell group antigens according to their parents’ birth region. In this study, 4% of participants whose parents were born in America, Europe, South Asia, and other countries expressed the K antigen. No participants whose parents were born in Korea or East Asia expressed the K antigen. The frequency of the anti-K is expected to increase because of blood donors with the K antigen. Therefore, it is necessary to consider the K antigen frequency and anti-K in transfusions and pregnancy cases in Korea. (Korean J Blood Transfus 2021;32:132-134)
{"title":"Clinical Importance and the Prevalence of Kell Group Antigen in Korea according to Ethnicity","authors":"Kyung-Hwa Shin, Hyun Ji Lee, Hyung-Hoi Kim","doi":"10.17945/kjbt.2021.32.2.132","DOIUrl":"https://doi.org/10.17945/kjbt.2021.32.2.132","url":null,"abstract":"The anti-K antibody has a role in transfusion reactions or hemolytic disease of the fetus and newborns. The K antigen is rarely expressed in Koreans. On the other hand, the distribution of blood group antigens has changed in recent years owing to the increased number of immigrants. This study examined the prevalence of the Kell group antigens according to their parents’ birth region. In this study, 4% of participants whose parents were born in America, Europe, South Asia, and other countries expressed the K antigen. No participants whose parents were born in Korea or East Asia expressed the K antigen. The frequency of the anti-K is expected to increase because of blood donors with the K antigen. Therefore, it is necessary to consider the K antigen frequency and anti-K in transfusions and pregnancy cases in Korea. (Korean J Blood Transfus 2021;32:132-134)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127974954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.17945/kjbt.2021.32.2.123
Jungwon Kang, JaeSook Lee, Dae Ho Ko, J. Kang, Yu Soek Jung, M. Youn
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CopyrightC2021 The Korean Society of Blood Transfusion 말라리아 헌혈제한지역에 대한 일시적 전혈헌혈 허용에 따른 말라리아 핵산증폭검사 결과 분석
this is an open access article distributed under the terms of the creative creativecommons attribution non - commercial license (http: / /听说过。org / licenses / by - nc / 4.0) which permits unrestrictednon-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited。CopyrightC2021 The Korean Society of Blood Transfusion对疟疾献血限制地区暂时允许献血导致疟疾核酸增幅检查结果分析
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