Pub Date : 2019-12-31DOI: 10.17945/kjbt.2019.30.3.212
M. Kim, Hyun Ji Lee, Soo Hwa Kang, S. Lee, I. Kim, Chulhun L. Chang
Background: Blood transfusion poses high risks and has a high probability of error because of the complexity and involvement of several people in the process. The purpose of this study was to share our experience in classifying reports related to blood transfusions. We included patient safety reports that were prepared over a 10-year period that began from the opening of the hospital. We then analyzed the causes and the corrective actions. Methods: We analyzed 125 reports related to blood transfusions, and these reports were included in the patient safety reports received from November 2008 to December 2018. The events were categorized as sampling error, inspection error, testing error, issue error, disposal error, transfusing blood components error, or others error, depending on the stage of the blood transfusion process. Regardless of the cause, the event that led to an inappropriate transfusion was classified as a transfusion incident. Results: The number of blood transfusions per year increased, and the rate of blood transfusion accidents ranged from 0.00% to 0.05% per year. A total of 125 reports were prepared over a 10-year period, and these included 8 blood sampling errors, 11 testing errors, 2 issuing errors, 94 disposal errors, 3 others errors, and 7 errors associated with the transfusing of blood components. After the transfusion incident, PDA was applied as a solution. Transfusing the wrong blood components did not occur, and the incidence of taking blood from the wrong patients was decreased. Conclusion: We applied corrective actions according to the cause of the event and we confirmed that the blood transfusion incidents decreased. (Korean J Blood Transfus 2019;30:212-218)
{"title":"Experience with Analyzing Patient Safety Incident Reports and Applying Corrective Action in a Blood Bank","authors":"M. Kim, Hyun Ji Lee, Soo Hwa Kang, S. Lee, I. Kim, Chulhun L. Chang","doi":"10.17945/kjbt.2019.30.3.212","DOIUrl":"https://doi.org/10.17945/kjbt.2019.30.3.212","url":null,"abstract":"Background: Blood transfusion poses high risks and has a high probability of error because of the complexity and involvement of several people in the process. The purpose of this study was to share our experience in classifying reports related to blood transfusions. We included patient safety reports that were prepared over a 10-year period that began from the opening of the hospital. We then analyzed the causes and the corrective actions. Methods: We analyzed 125 reports related to blood transfusions, and these reports were included in the patient safety reports received from November 2008 to December 2018. The events were categorized as sampling error, inspection error, testing error, issue error, disposal error, transfusing blood components error, or others error, depending on the stage of the blood transfusion process. Regardless of the cause, the event that led to an inappropriate transfusion was classified as a transfusion incident. Results: The number of blood transfusions per year increased, and the rate of blood transfusion accidents ranged from 0.00% to 0.05% per year. A total of 125 reports were prepared over a 10-year period, and these included 8 blood sampling errors, 11 testing errors, 2 issuing errors, 94 disposal errors, 3 others errors, and 7 errors associated with the transfusing of blood components. After the transfusion incident, PDA was applied as a solution. Transfusing the wrong blood components did not occur, and the incidence of taking blood from the wrong patients was decreased. Conclusion: We applied corrective actions according to the cause of the event and we confirmed that the blood transfusion incidents decreased. (Korean J Blood Transfus 2019;30:212-218)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126393146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.17945/kjbt.2019.30.3.241
Han-Sol Kim, Chae-Ku Jo, Sinyoung Kim, K. Kim, M. Kim
A Case of Hemolytic Disease of Newborn due to Anti-Di: Consideration of the Inclusion of Di Antigen in Antibody Screening Test Han-Sol Kim, Chae-Ku Jo, Sin-Young Kim, Kyeong-Hee Kim, Myo-Jing Kim Department of Pediatrics, Dong-A University Hospital, Busan, Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Departments of Laboratory Medicine and Pediatrics, Dong-A University College of Medicine, Busan, Korea
{"title":"A Case of Hemolytic Disease of Newborn due to Anti-Dia: Consideration of the Inclusion of Dia Antigen in Antibody Screening Test","authors":"Han-Sol Kim, Chae-Ku Jo, Sinyoung Kim, K. Kim, M. Kim","doi":"10.17945/kjbt.2019.30.3.241","DOIUrl":"https://doi.org/10.17945/kjbt.2019.30.3.241","url":null,"abstract":"A Case of Hemolytic Disease of Newborn due to Anti-Di: Consideration of the Inclusion of Di Antigen in Antibody Screening Test Han-Sol Kim, Chae-Ku Jo, Sin-Young Kim, Kyeong-Hee Kim, Myo-Jing Kim Department of Pediatrics, Dong-A University Hospital, Busan, Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Departments of Laboratory Medicine and Pediatrics, Dong-A University College of Medicine, Busan, Korea","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"239 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130953003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-31DOI: 10.17945/kjbt.2019.30.2.124
J. Lee, S. Song, S. Oh
{"title":"Molecular Genetic and Serologic Analysis of theOallele in the Korean Population","authors":"J. Lee, S. Song, S. Oh","doi":"10.17945/kjbt.2019.30.2.124","DOIUrl":"https://doi.org/10.17945/kjbt.2019.30.2.124","url":null,"abstract":"","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131086554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-31DOI: 10.17945/kjbt.2019.30.2.174
Pil Sun Nam
{"title":"Experiences of Blood Bank Performance in Brian Allgood Army Community Hospital","authors":"Pil Sun Nam","doi":"10.17945/kjbt.2019.30.2.174","DOIUrl":"https://doi.org/10.17945/kjbt.2019.30.2.174","url":null,"abstract":"","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114953067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-31DOI: 10.17945/kjbt.2019.30.2.168
Taeo Ma, HongBi Yu, Suhak Jeon, D. Cho, S. Chun, M. Shin
D antigens are clinically significant, and routine tests on the D antigen requires the inclusion of weak D testing, which is performed using indirect antihuman immunoglobulin methods. On the other hand, exact typing of the D type of an individual can be done more precisely with RHD genotyping, which is a useful tool in cases where the RHD gene is intact. The majority of weak-D or partial-D cases are from single nucleotide changes or hybridization of RHD and RHCE genes. Nevertheless, frameshift mutations can also result in weak or partial-D. The characteristics of a frameshift mutation is typically a change in protein product after a problematic mutation and early termination of transcription, leading into truncated protein products. This paper reports a D-variant case with RHD 711delC along with a review of the relevant literature. In addition, the results of software analysis are reported. (Korean J Blood Transfus 2019;30:168-173)
{"title":"Case of D-Variant from a Frameshift MutationRHD711delC","authors":"Taeo Ma, HongBi Yu, Suhak Jeon, D. Cho, S. Chun, M. Shin","doi":"10.17945/kjbt.2019.30.2.168","DOIUrl":"https://doi.org/10.17945/kjbt.2019.30.2.168","url":null,"abstract":"D antigens are clinically significant, and routine tests on the D antigen requires the inclusion of weak D testing, which is performed using indirect antihuman immunoglobulin methods. On the other hand, exact typing of the D type of an individual can be done more precisely with RHD genotyping, which is a useful tool in cases where the RHD gene is intact. The majority of weak-D or partial-D cases are from single nucleotide changes or hybridization of RHD and RHCE genes. Nevertheless, frameshift mutations can also result in weak or partial-D. The characteristics of a frameshift mutation is typically a change in protein product after a problematic mutation and early termination of transcription, leading into truncated protein products. This paper reports a D-variant case with RHD 711delC along with a review of the relevant literature. In addition, the results of software analysis are reported. (Korean J Blood Transfus 2019;30:168-173)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133457668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-31DOI: 10.17945/kjbt.2019.30.2.148
Cheon-Gang Park, A-Jin Lee, Seon-Ho Mun, Sang-Gyung Kim, C. Jeon, H. Suh
Background: Therapeutic plasma exchange (TPE) is used to remove pathologic substances involved in various disease etiologies. The use of TPE is increasing steadily in a variety of disease. This study analyzed the incidence, type and severity of adverse events (AE) according to the initial TPE of each patient in a single center. The risk factors for AE of TPE were also elucidated. Methods: The medical and laboratory records of patients, who received TPE from January 2014 to December 2018, were reviewed retrospectively. The signs or symptoms during and after TPE were analyzed. Results: TPE sessions were performed on 95 patients. The mean age was 53.3 years and men comprised 63.2%. The most common indication for TPE was desensitization for ABO-incompatible liver transplantation (ABO-i LT) (N=56, 58.9%). A total of 27 patients (28.4%) experienced AE during the initial TPE. The types of AE were allergic reactions (N=14, 14.7%), anaphylactic reaction (N=3, 11.1%), hypotension (N=5, 5.3%), hypocalcemic reaction (N=4, 4.2%), and febrile nonhemolytic reaction (N=1, 1.1%). The severities of AE were evaluated as mild in eight procedures (8.4 %), moderate in seventeen (17.9 %), and severe in two (2.1 %). Multivariable logistic regression analysis showed that the desensitization for ABO-i LT (odds ratio (OR), 2.08; 95% CI, 1.03∼4.22) and the amount of FFP (OR, 1.07; 95% CI, 1.01∼1.09) were associated with a higher incidence of AE. Conclusion: TPE can be performed under careful patient monitoring to provide prompt intervention, particularly in patients with desensitization of ABO-i LT using FFP. (Korean J Blood Transfus 2019;30:148-155)
{"title":"Risk Factors for Adverse Events of Therapeutic Plasma Exchange Assessed in a Single Center Study","authors":"Cheon-Gang Park, A-Jin Lee, Seon-Ho Mun, Sang-Gyung Kim, C. Jeon, H. Suh","doi":"10.17945/kjbt.2019.30.2.148","DOIUrl":"https://doi.org/10.17945/kjbt.2019.30.2.148","url":null,"abstract":"Background: Therapeutic plasma exchange (TPE) is used to remove pathologic substances involved in various disease etiologies. The use of TPE is increasing steadily in a variety of disease. This study analyzed the incidence, type and severity of adverse events (AE) according to the initial TPE of each patient in a single center. The risk factors for AE of TPE were also elucidated. Methods: The medical and laboratory records of patients, who received TPE from January 2014 to December 2018, were reviewed retrospectively. The signs or symptoms during and after TPE were analyzed. Results: TPE sessions were performed on 95 patients. The mean age was 53.3 years and men comprised 63.2%. The most common indication for TPE was desensitization for ABO-incompatible liver transplantation (ABO-i LT) (N=56, 58.9%). A total of 27 patients (28.4%) experienced AE during the initial TPE. The types of AE were allergic reactions (N=14, 14.7%), anaphylactic reaction (N=3, 11.1%), hypotension (N=5, 5.3%), hypocalcemic reaction (N=4, 4.2%), and febrile nonhemolytic reaction (N=1, 1.1%). The severities of AE were evaluated as mild in eight procedures (8.4 %), moderate in seventeen (17.9 %), and severe in two (2.1 %). Multivariable logistic regression analysis showed that the desensitization for ABO-i LT (odds ratio (OR), 2.08; 95% CI, 1.03∼4.22) and the amount of FFP (OR, 1.07; 95% CI, 1.01∼1.09) were associated with a higher incidence of AE. Conclusion: TPE can be performed under careful patient monitoring to provide prompt intervention, particularly in patients with desensitization of ABO-i LT using FFP. (Korean J Blood Transfus 2019;30:148-155)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134370711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-31DOI: 10.17945/kjbt.2019.30.2.138
W. Shin, Jeong Jae Lee, Haran Chung, J. Shin
Background: Transfusion guidelines are not only essential for the optimal use of blood products, but also help reduce transfusion-related adverse reactions and improve patients’ outcomes. In this hospital, a transfusion-indication data-entry program based on the national transfusion guidelines was developed and applied to the electronic medical record system in 2016. All transfusion orders, except for emergencies, have been performed using this program since then. This study analyzed the reasons for the transfusion to monitor the blood product usage and provide feedback to clinicians. Methods: The transfusion-indications were classified by the blood product and a pop-up window listing these indications was produced. The indications were as follows: red blood cells (RBCs) - acute blood loss, chronic anemia, surgery/procedure, transplantation and ‘other’; platelets (PLTs) - active bleeding, bleeding prophylaxis, surgery/procedure, massive transfusion, and ‘other’; fresh frozen plasma (FFP) - bleeding in coagulopathy, bleeding prophylaxis in coagulopathy, massive transfusion, plasma exchange, and ‘other’. The indications entered into the data-entry program from Sep 2016 to Feb 2018 were analyzed. Results: The most common indications for transfusion were chronic anemia for RBCs (7977/16138, 49.4%), bleeding prophylaxis for PLTs (5726/11158, 51.3%), and ‘other’ for FFP (2180/6024, 36.2%). Many clinicians entered the transfusion indication as ‘other’, but the free-text supplied by the clinician when ‘other’ was selected, often corresponded to an indication already categorized in the transfusion-indication data-entry program. Conclusion: Feedback and training on the data of transfusion indications are needed for clinicians to properly use blood products by operating the transfusion-indication data-entry program more efficiently. (Korean J Blood Transfus 2019;30:138-147)
{"title":"Development of a Transfusion-Indication Data-Entry Program and Analysis of Transfusion Indications at a University Hospital in Korea","authors":"W. Shin, Jeong Jae Lee, Haran Chung, J. Shin","doi":"10.17945/kjbt.2019.30.2.138","DOIUrl":"https://doi.org/10.17945/kjbt.2019.30.2.138","url":null,"abstract":"Background: Transfusion guidelines are not only essential for the optimal use of blood products, but also help reduce transfusion-related adverse reactions and improve patients’ outcomes. In this hospital, a transfusion-indication data-entry program based on the national transfusion guidelines was developed and applied to the electronic medical record system in 2016. All transfusion orders, except for emergencies, have been performed using this program since then. This study analyzed the reasons for the transfusion to monitor the blood product usage and provide feedback to clinicians. Methods: The transfusion-indications were classified by the blood product and a pop-up window listing these indications was produced. The indications were as follows: red blood cells (RBCs) - acute blood loss, chronic anemia, surgery/procedure, transplantation and ‘other’; platelets (PLTs) - active bleeding, bleeding prophylaxis, surgery/procedure, massive transfusion, and ‘other’; fresh frozen plasma (FFP) - bleeding in coagulopathy, bleeding prophylaxis in coagulopathy, massive transfusion, plasma exchange, and ‘other’. The indications entered into the data-entry program from Sep 2016 to Feb 2018 were analyzed. Results: The most common indications for transfusion were chronic anemia for RBCs (7977/16138, 49.4%), bleeding prophylaxis for PLTs (5726/11158, 51.3%), and ‘other’ for FFP (2180/6024, 36.2%). Many clinicians entered the transfusion indication as ‘other’, but the free-text supplied by the clinician when ‘other’ was selected, often corresponded to an indication already categorized in the transfusion-indication data-entry program. Conclusion: Feedback and training on the data of transfusion indications are needed for clinicians to properly use blood products by operating the transfusion-indication data-entry program more efficiently. (Korean J Blood Transfus 2019;30:138-147)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121964098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-31DOI: 10.17945/kjbt.2019.30.2.101
S. Choi, Yoo Na Chung, D. Cho, Sinyoung Kim
Antibodies to high-incidence red blood cell antigens should be considered if panagglutination reactions are noted in all panel cells, and negative reactions to autologous red blood cells are detected on antibody screening and identification tests. In Korea, most of those antibodies are identified through international reference laboratories. To prevent a hemolytic transfusion reaction, antigen-negative red cells should be provided for those patients who have antibodies to red cell antigens. However, this is nearly impossible when the antibody has specificity to high-incidence red cell antigen. In those cases, transfusion of autologous blood, cryopreserved rare blood and the least incompatible blood components can be considered. In the case of surgery, acute normovolemic hemodilution or intraoperative blood salvage can also be considered. For the patients who have antibodies to high-incidence red cell antigens, it should be discussed to set up a national reference laboratory to quickly identify antibody specificities, and to consider establishing rare blood donor registry and frozen rare blood storage/supply system. This article reviews characteristics of antibodies to high-incidence antigens found in Koreans and also the transfusion experiences of those patients based on literature. (Korean J Blood Transfus 2019;30:101-112)
{"title":"Alloantibodies to High-Incidence Antigen: Review of Cases and Transfusion Experiences in Korea","authors":"S. Choi, Yoo Na Chung, D. Cho, Sinyoung Kim","doi":"10.17945/kjbt.2019.30.2.101","DOIUrl":"https://doi.org/10.17945/kjbt.2019.30.2.101","url":null,"abstract":"Antibodies to high-incidence red blood cell antigens should be considered if panagglutination reactions are noted in all panel cells, and negative reactions to autologous red blood cells are detected on antibody screening and identification tests. In Korea, most of those antibodies are identified through international reference laboratories. To prevent a hemolytic transfusion reaction, antigen-negative red cells should be provided for those patients who have antibodies to red cell antigens. However, this is nearly impossible when the antibody has specificity to high-incidence red cell antigen. In those cases, transfusion of autologous blood, cryopreserved rare blood and the least incompatible blood components can be considered. In the case of surgery, acute normovolemic hemodilution or intraoperative blood salvage can also be considered. For the patients who have antibodies to high-incidence red cell antigens, it should be discussed to set up a national reference laboratory to quickly identify antibody specificities, and to consider establishing rare blood donor registry and frozen rare blood storage/supply system. This article reviews characteristics of antibodies to high-incidence antigens found in Koreans and also the transfusion experiences of those patients based on literature. (Korean J Blood Transfus 2019;30:101-112)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117096102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-31DOI: 10.17945/kjbt.2019.30.2.178
Jungwon Kang, Sunmi Shin, J. Kang, Y. I. Seo, H. Min
{"title":"Erratum: Author’s order correction Comparison of the Effectiveness in the Application of Competitive and Noncompetitive Internal Control for the Laboratory Developed Polymerase Chain Reaction","authors":"Jungwon Kang, Sunmi Shin, J. Kang, Y. I. Seo, H. Min","doi":"10.17945/kjbt.2019.30.2.178","DOIUrl":"https://doi.org/10.17945/kjbt.2019.30.2.178","url":null,"abstract":"","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130990064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-31DOI: 10.17945/kjbt.2019.30.2.163
Jungwon Kang, Sunmi Shin, J. Kang, Y. I. Seo, H. Min, Myunghan Kim
HBV core antibody and surface antibody test are currently conducted for those donors showing non-discriminated reactive (NDR) results on a nucleic acid amplification test (NAT) as a blood donor screening assay. It is necessary to investigate the relationship with HCV or HIV in the donors showing NDR results. From June 12th, 2012 to December 31st, 2018, 0.05% (9,020/17,798,461) donors showed NDR results on a NAT. Among the donors showing NDR results, 17 and 18 donors showed positive results on serological assay of HCV and HIV, respectively. 23 donors with NDR results showed positive results on the serological assay or NAT for HCV or HIV on the following donation. Further study and more accumulated data are required because it may be difficult to find the cause of NDR results by the current serological assay that is used for screening blood donors. (Korean J Blood Transfus 2019;30:163-167)
{"title":"Investigation of the Association of HCV or HIV Markers in Non-Discriminated Blood Donations","authors":"Jungwon Kang, Sunmi Shin, J. Kang, Y. I. Seo, H. Min, Myunghan Kim","doi":"10.17945/kjbt.2019.30.2.163","DOIUrl":"https://doi.org/10.17945/kjbt.2019.30.2.163","url":null,"abstract":"HBV core antibody and surface antibody test are currently conducted for those donors showing non-discriminated reactive (NDR) results on a nucleic acid amplification test (NAT) as a blood donor screening assay. It is necessary to investigate the relationship with HCV or HIV in the donors showing NDR results. From June 12th, 2012 to December 31st, 2018, 0.05% (9,020/17,798,461) donors showed NDR results on a NAT. Among the donors showing NDR results, 17 and 18 donors showed positive results on serological assay of HCV and HIV, respectively. 23 donors with NDR results showed positive results on the serological assay or NAT for HCV or HIV on the following donation. Further study and more accumulated data are required because it may be difficult to find the cause of NDR results by the current serological assay that is used for screening blood donors. (Korean J Blood Transfus 2019;30:163-167)","PeriodicalId":231122,"journal":{"name":"The Korean Journal of Blood Transfusion","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126520081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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