Pub Date : 2024-03-25DOI: 10.1080/24734306.2024.2314314
William Banner, Kristie L. Edelen, L. C. Epperson, Eszter Moore
{"title":"Hypersensitivity reactions due to North American pit viper antivenom administration and confirmed elevation of alpha-gal IgE","authors":"William Banner, Kristie L. Edelen, L. C. Epperson, Eszter Moore","doi":"10.1080/24734306.2024.2314314","DOIUrl":"https://doi.org/10.1080/24734306.2024.2314314","url":null,"abstract":"","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":" 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140385062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-11DOI: 10.1080/24734306.2024.2325791
Kara A. Yeung, Riku Moriguchi, Jeremy R. Hardin, Henrik Galust, Bryan Corbett, Alicia B. Minns
{"title":"Delayed local chemical burns following dermal exposure to bromoacetic acid: a case report","authors":"Kara A. Yeung, Riku Moriguchi, Jeremy R. Hardin, Henrik Galust, Bryan Corbett, Alicia B. Minns","doi":"10.1080/24734306.2024.2325791","DOIUrl":"https://doi.org/10.1080/24734306.2024.2325791","url":null,"abstract":"","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"40 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140253514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-21DOI: 10.1080/24734306.2023.2293403
Mir Mazhar, Adrian Estrada, Alexander Zorn, Robert V. Madlinger, Maurizio Miglietta
{"title":"Severe and refractory hypotension after intentional minoxidil overdose: a case report","authors":"Mir Mazhar, Adrian Estrada, Alexander Zorn, Robert V. Madlinger, Maurizio Miglietta","doi":"10.1080/24734306.2023.2293403","DOIUrl":"https://doi.org/10.1080/24734306.2023.2293403","url":null,"abstract":"","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138952192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-11DOI: 10.1080/24734306.2023.2286391
Ibrahim Halil Toksul, I. Altundag, Rıza Çete, Ziad Kazzi, Semih Korkut, Aynur Şahin
{"title":"Successful management of a colchicine overdose with plasmapheresis: a case report","authors":"Ibrahim Halil Toksul, I. Altundag, Rıza Çete, Ziad Kazzi, Semih Korkut, Aynur Şahin","doi":"10.1080/24734306.2023.2286391","DOIUrl":"https://doi.org/10.1080/24734306.2023.2286391","url":null,"abstract":"","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"63 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138981639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-02DOI: 10.1080/24734306.2023.2285123
Huda Khalid, Manal E. Siyam, Muhammad E. M. O. Elamin, R. Azrag
{"title":"Scorpion stings envenomation in Sudan: a retrospective study of hospital-based incidence","authors":"Huda Khalid, Manal E. Siyam, Muhammad E. M. O. Elamin, R. Azrag","doi":"10.1080/24734306.2023.2285123","DOIUrl":"https://doi.org/10.1080/24734306.2023.2285123","url":null,"abstract":"","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"84 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138606303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-02DOI: 10.1080/24734306.2023.2280893
Erin Ryan, S. Atti, Stacy Marshall, Jessica Rivera, William Rushton
{"title":"Repeat antivenom administration following crotalidae immune F(ab’)2 antivenom in Agkistrodon species: a case series","authors":"Erin Ryan, S. Atti, Stacy Marshall, Jessica Rivera, William Rushton","doi":"10.1080/24734306.2023.2280893","DOIUrl":"https://doi.org/10.1080/24734306.2023.2280893","url":null,"abstract":"","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"121 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138607225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-02DOI: 10.1080/24734306.2023.2283310
Najeeb Alqarni, Faisal G Almalki, Faris Nouh, Maher Nahari
{"title":"Severe pneumonitis due to prallethrin (pyrethroid) aspiration: a case report","authors":"Najeeb Alqarni, Faisal G Almalki, Faris Nouh, Maher Nahari","doi":"10.1080/24734306.2023.2283310","DOIUrl":"https://doi.org/10.1080/24734306.2023.2283310","url":null,"abstract":"","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"123 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138607197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-27DOI: 10.1080/24734306.2023.2272073
Fazle Rabbi Chowdhury, Suvodip Shaw, Abdullah Abu Sayeed, Soumitra Roy, Abu Shahin Mohammad Mahbubur Rahman, Nahida Zafrin, Pritish Tarafder, Muhammad Halimur Rashid, A. Ghose, Shishir Ranjan Chakraborty, Muhammad Khalilur Rahman, Muhammad Sayedur Rahman, R. Parker, Muhammad Mahib Ullah, Zakir Hassan, A. Sohag, Muhammad Robed Amin, Muhammad Shafiqul Bari, John Norrie, M. A. Faiz, Michael Eddleston
Abstract Pesticide self-poisoning is one of the three most important global means of suicide, killing an estimated 110–168,000 people each year, mostly in poor rural Asian communities. Organophosphorus (OP) and carbamate anticholinesterase insecticides are responsible for about two-thirds of these deaths. Calcium channel blocking medicines (CCB) may reduce the effect of pesticides and prevent deaths. Two preclinical rodents’ studies and eight clinical studies utilising nimodipine and magnesium sulphate (MgSO4), respectively, showed mixed results. We have established a multi-centre randomised controlled trial (RCT) of patients with OP or carbamate self-poisoning admitted to at least six major hospitals in Bangladesh. The study aims to recruit maximum 3,243 patients over four years. One-third of the patients selected at random will receive standard treatment, while one-third will be treated with additional nimodipine and one-third with additional MgSO4. The additional treatments will be given for 48 h. We will check mortality (currently an estimated 11% die with standard treatment) and need for intensive care for mechanical ventilation across the three groups. This could lead to development of the first novel treatment for anticholinesterase poisoning in 50 years and its introduction into routine hospital practice worldwide.
{"title":"Effectiveness of calcium channel blockade for organophosphorus and carbamate pesticide poisoning – study protocol for an open label, pragmatic, 3-arm RCT repurposing two widely available medicines","authors":"Fazle Rabbi Chowdhury, Suvodip Shaw, Abdullah Abu Sayeed, Soumitra Roy, Abu Shahin Mohammad Mahbubur Rahman, Nahida Zafrin, Pritish Tarafder, Muhammad Halimur Rashid, A. Ghose, Shishir Ranjan Chakraborty, Muhammad Khalilur Rahman, Muhammad Sayedur Rahman, R. Parker, Muhammad Mahib Ullah, Zakir Hassan, A. Sohag, Muhammad Robed Amin, Muhammad Shafiqul Bari, John Norrie, M. A. Faiz, Michael Eddleston","doi":"10.1080/24734306.2023.2272073","DOIUrl":"https://doi.org/10.1080/24734306.2023.2272073","url":null,"abstract":"Abstract Pesticide self-poisoning is one of the three most important global means of suicide, killing an estimated 110–168,000 people each year, mostly in poor rural Asian communities. Organophosphorus (OP) and carbamate anticholinesterase insecticides are responsible for about two-thirds of these deaths. Calcium channel blocking medicines (CCB) may reduce the effect of pesticides and prevent deaths. Two preclinical rodents’ studies and eight clinical studies utilising nimodipine and magnesium sulphate (MgSO4), respectively, showed mixed results. We have established a multi-centre randomised controlled trial (RCT) of patients with OP or carbamate self-poisoning admitted to at least six major hospitals in Bangladesh. The study aims to recruit maximum 3,243 patients over four years. One-third of the patients selected at random will receive standard treatment, while one-third will be treated with additional nimodipine and one-third with additional MgSO4. The additional treatments will be given for 48 h. We will check mortality (currently an estimated 11% die with standard treatment) and need for intensive care for mechanical ventilation across the three groups. This could lead to development of the first novel treatment for anticholinesterase poisoning in 50 years and its introduction into routine hospital practice worldwide.","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"277 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139228998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-21DOI: 10.1080/24734306.2023.2272072
A. Holford, K. Isoardi
Abstract Severe toxicity from povidone-iodine is rare, causing metabolic acidosis from the conversion of iodine to sodium iodide and direct tissue destruction. We report a case of fatal iodine toxicity following sclerotherapy. An elderly man presented following ablation of a large renal cyst with 10% povidone-iodine and 100% ethanol. He appeared intoxicated however denied alcohol ingestion. Over hours he developed progressive hypotension despite multiple vasopressor agents. Blood gas analysis demonstrated a metabolic acidosis (pH 7.11, bicarbonate 13 mmol/L) with an apparent hyperchloremia of 124 mmol/L. The ethanol concentration was 55 mmol/L (249 mg/dL). Imaging confirmed large volume residual radio-opaque fluid at the procedure site. The fluid was percutaneously drained and dialysis commenced for iodine toxicity. Iodine concentrations peaked at 8940 µmol/L (reference range 0.32-0.63 µmol/L) 14.5 h post exposure. Point of care chloride concentrations remained elevated (peak 129 mmol/L) following the trend of iodine concentrations, normalising once the iodine concentration was 1559 µmol/L. The patient deteriorated despite maximal therapy and succumbed on day 3. Iodide interferes with point of care testing chloride measurements. Point of care chloride concentrations may have a role as a surrogate marker for iodine but only at very high iodine concentrations (>2000 µmol/L).
{"title":"A fatal case of iatrogenic iodine poisoning: is point of care chloride a useful iodine surrogate marker?","authors":"A. Holford, K. Isoardi","doi":"10.1080/24734306.2023.2272072","DOIUrl":"https://doi.org/10.1080/24734306.2023.2272072","url":null,"abstract":"Abstract Severe toxicity from povidone-iodine is rare, causing metabolic acidosis from the conversion of iodine to sodium iodide and direct tissue destruction. We report a case of fatal iodine toxicity following sclerotherapy. An elderly man presented following ablation of a large renal cyst with 10% povidone-iodine and 100% ethanol. He appeared intoxicated however denied alcohol ingestion. Over hours he developed progressive hypotension despite multiple vasopressor agents. Blood gas analysis demonstrated a metabolic acidosis (pH 7.11, bicarbonate 13 mmol/L) with an apparent hyperchloremia of 124 mmol/L. The ethanol concentration was 55 mmol/L (249 mg/dL). Imaging confirmed large volume residual radio-opaque fluid at the procedure site. The fluid was percutaneously drained and dialysis commenced for iodine toxicity. Iodine concentrations peaked at 8940 µmol/L (reference range 0.32-0.63 µmol/L) 14.5 h post exposure. Point of care chloride concentrations remained elevated (peak 129 mmol/L) following the trend of iodine concentrations, normalising once the iodine concentration was 1559 µmol/L. The patient deteriorated despite maximal therapy and succumbed on day 3. Iodide interferes with point of care testing chloride measurements. Point of care chloride concentrations may have a role as a surrogate marker for iodine but only at very high iodine concentrations (>2000 µmol/L).","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139252805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zoledronic acid is an intravenous (IV) bisphosphonate used to treat bone metastases associated with solid tumors and metabolic bone disorders. It is an established treatment option for children with osteogenesis imperfect (OI). Its efficacy relies on its higher potency and affinity for bone, shorter infusion time, and long-acting kinetics. While therapeutic safety and efficacy have been established, zoledronic acid overdose has been rarely reported. We present a case of a 15-fold zoledronic acid overdose in a 2-year-old child treated for OI requiring pediatric intensive care unit admission. The patient developed hypocalcemia and hypophosphatemia requiring repletion along with ergocalciferol supplementation. He also developed a transient acute phase reaction and electrocardiogram disturbances and underwent hemodialysis. He was discharged on hospital day 12. Zoledronic acid has been associated with electrolyte abnormalities, nephrotoxicity, acute inflammatory responses, metabolic derangements, and arrhythmias. A lack of zoledronic acid concentrations limited our ability to characterize a toxicokinetic profile and precluded an interpretation of the relationship between serum concentrations and clinical effects. Limited clinical experience and literature were available to guide the management of this overdose. Management approach principles should be based on aggressive electrolyte monitoring and supplementation, renal function and cardiac monitoring, and pre-and post-morbid assessment of metabolic parameters.
{"title":"Zoledronic acid overdose in a two-year-old with osteogenesis imperfecta","authors":"Brandtly Yakey, Mirjana Dimovska, Bram Dolcourt, Varun Vohra","doi":"10.1080/24734306.2023.2260146","DOIUrl":"https://doi.org/10.1080/24734306.2023.2260146","url":null,"abstract":"Zoledronic acid is an intravenous (IV) bisphosphonate used to treat bone metastases associated with solid tumors and metabolic bone disorders. It is an established treatment option for children with osteogenesis imperfect (OI). Its efficacy relies on its higher potency and affinity for bone, shorter infusion time, and long-acting kinetics. While therapeutic safety and efficacy have been established, zoledronic acid overdose has been rarely reported. We present a case of a 15-fold zoledronic acid overdose in a 2-year-old child treated for OI requiring pediatric intensive care unit admission. The patient developed hypocalcemia and hypophosphatemia requiring repletion along with ergocalciferol supplementation. He also developed a transient acute phase reaction and electrocardiogram disturbances and underwent hemodialysis. He was discharged on hospital day 12. Zoledronic acid has been associated with electrolyte abnormalities, nephrotoxicity, acute inflammatory responses, metabolic derangements, and arrhythmias. A lack of zoledronic acid concentrations limited our ability to characterize a toxicokinetic profile and precluded an interpretation of the relationship between serum concentrations and clinical effects. Limited clinical experience and literature were available to guide the management of this overdose. Management approach principles should be based on aggressive electrolyte monitoring and supplementation, renal function and cardiac monitoring, and pre-and post-morbid assessment of metabolic parameters.","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136130664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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